UA88771C2 - Proteasome inhibitors and methods of using the same (variants) - Google Patents
Proteasome inhibitors and methods of using the same (variants)Info
- Publication number
- UA88771C2 UA88771C2 UAA200602694A UAA200602694A UA88771C2 UA 88771 C2 UA88771 C2 UA 88771C2 UA A200602694 A UAA200602694 A UA A200602694A UA A200602694 A UAA200602694 A UA A200602694A UA 88771 C2 UA88771 C2 UA 88771C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- variants
- same
- proteasome inhibitors
- compositions
- Prior art date
Links
- 229940079156 Proteasome inhibitor Drugs 0.000 title 1
- 239000003207 proteasome inhibitor Substances 0.000 title 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 abstract 2
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001642 boronic acid derivatives Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49576403P | 2003-08-14 | 2003-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA88771C2 true UA88771C2 (en) | 2009-11-25 |
Family
ID=37426112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200602694A UA88771C2 (en) | 2003-08-14 | 2004-08-13 | Proteasome inhibitors and methods of using the same (variants) |
Country Status (7)
| Country | Link |
|---|---|
| CN (1) | CN1867572B (en) |
| AR (2) | AR045381A1 (en) |
| MY (1) | MY162518A (en) |
| PE (1) | PE20050360A1 (en) |
| TW (1) | TWI345465B (en) |
| UA (1) | UA88771C2 (en) |
| ZA (1) | ZA200601293B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961387B (en) * | 2007-08-06 | 2016-04-27 | 米伦纽姆医药公司 | Proteasome inhibitor |
| GEP20125599B (en) * | 2007-08-06 | 2012-08-10 | Millennium Pharm Inc | Proteasome inhibitors |
| CN105837608B (en) * | 2007-08-06 | 2018-06-08 | 米伦纽姆医药公司 | Proteasome inhibitor and combinations thereof and purposes |
| BR122014008753A2 (en) * | 2008-06-17 | 2015-12-29 | Millennium Pharm Inc | boronate ester compounds and pharmaceutical compositions thereof |
| CN101638414B (en) * | 2008-07-30 | 2014-01-08 | 江苏先声药物研究有限公司 | Peptidyl boronic acid, ester compound thereof, preparation method of peptidyl boronic acid and ester compound thereof, and use of peptidyl boronic acid and ester compound thereof |
| AR075090A1 (en) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. |
| CN101747354B (en) * | 2008-12-04 | 2014-08-13 | 江苏先声药物研究有限公司 | Dipeptide boronic acids consisting of beta amino acids, ester compounds and preparation methods and uses thereof |
| CN102725300B (en) * | 2009-12-22 | 2015-03-11 | 赛福伦公司 | Proteasome inhibitors and processes for their preparation, purification and use |
| CN106008570A (en) * | 2010-03-31 | 2016-10-12 | 米伦纽姆医药公司 | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| JP6662865B2 (en) * | 2014-10-01 | 2020-03-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Boronic acid derivatives |
| CN106588965A (en) | 2015-10-15 | 2017-04-26 | 北京大学 | Urea peptidomimetic boric acid compound as well as pharmaceutical composition, preparation method and application thereof |
| CN107400142B (en) * | 2016-05-19 | 2019-11-19 | 成都奥璟生物科技有限公司 | A kind of boric acid and boric acid ester compound and its application |
| SI3571208T1 (en) * | 2017-01-18 | 2021-06-30 | Principia Biopharma Inc. | Immunoproteasome inhibitors |
| CN108440583B (en) * | 2017-01-23 | 2020-12-04 | 成都奥璟生物科技有限公司 | Boric acid derivative and its medicinal composition |
| CN114437119B (en) * | 2020-10-30 | 2024-08-09 | 苏州开拓药业股份有限公司 | C-Myc protein inhibitor and preparation method and application thereof |
| CN116726864A (en) * | 2023-06-09 | 2023-09-12 | 浙江美华鼎昌医药科技有限公司 | Synthesis process of raw material for treating multiple myeloma proteasome inhibitor |
| CN116712399A (en) * | 2023-06-09 | 2023-09-08 | 浙江美华鼎昌医药科技有限公司 | Preparation process of proteasome inhibitor capsules for treating multiple myeloma |
-
2004
- 2004-08-13 CN CN2004800301520A patent/CN1867572B/en not_active Expired - Lifetime
- 2004-08-13 MY MYPI20043299A patent/MY162518A/en unknown
- 2004-08-13 TW TW93124291A patent/TWI345465B/en not_active IP Right Cessation
- 2004-08-13 PE PE2004000784A patent/PE20050360A1/en active IP Right Grant
- 2004-08-13 UA UAA200602694A patent/UA88771C2/en unknown
- 2004-08-17 AR ARP040102935 patent/AR045381A1/en not_active Application Discontinuation
-
2006
- 2006-02-13 ZA ZA200601293A patent/ZA200601293B/en unknown
-
2014
- 2014-03-11 AR ARP140100859A patent/AR095249A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR095249A2 (en) | 2015-09-30 |
| MY162518A (en) | 2017-06-15 |
| CN1867572B (en) | 2012-03-28 |
| PE20050360A1 (en) | 2005-06-10 |
| AR045381A1 (en) | 2005-10-26 |
| TW200529810A (en) | 2005-09-16 |
| CN1867572A (en) | 2006-11-22 |
| TWI345465B (en) | 2011-07-21 |
| ZA200601293B (en) | 2009-09-30 |
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