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UA85578C2 - Микроэмульсионный препарат с высокой концентрацией пропофола для применения в анестезии - Google Patents

Микроэмульсионный препарат с высокой концентрацией пропофола для применения в анестезии

Info

Publication number
UA85578C2
UA85578C2 UAA200608747A UAA200608747A UA85578C2 UA 85578 C2 UA85578 C2 UA 85578C2 UA A200608747 A UAA200608747 A UA A200608747A UA A200608747 A UAA200608747 A UA A200608747A UA 85578 C2 UA85578 C2 UA 85578C2
Authority
UA
Ukraine
Prior art keywords
propofol
microemulsion
base composition
liquid
anesthesia
Prior art date
Application number
UAA200608747A
Other languages
English (en)
Ukrainian (uk)
Inventor
Стивен Б. Гаррис
Ник Дж. Гуан
Original Assignee
Байоавейлабилити Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоавейлабилити Инк. filed Critical Байоавейлабилити Инк.
Publication of UA85578C2 publication Critical patent/UA85578C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к самомикроэмульгирующейся базовой композиции, которая состоит из: пропофола и поверхностно-активного вещества, содержащего полиэтиленгликоль, причем неионное поверхностно-активное вещество включено в способную к самомикроэмульгированию базовую композицию в концентрации около 8 частей или более неионного поверхностно-активного вещества на одну часть пропофола. Базовая композиция не содержит ни одного другого неионного поверхностно-активного вещества, отличного от отмеченного неионного поверхностно-активного вещества, которое содержит полиэтиленгликоль, где самомикроэмульгирующаяся базовая композиция является оптически прозрачной жидкостью, безводной, гомогенной и пригодной для применения при получении микроэмульсии путем смешивания базовой композиции с жидким носителем.
UAA200608747A 2004-02-13 2005-02-14 Микроэмульсионный препарат с высокой концентрацией пропофола для применения в анестезии UA85578C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54460404P 2004-02-13 2004-02-13

Publications (1)

Publication Number Publication Date
UA85578C2 true UA85578C2 (ru) 2009-02-10

Family

ID=34886055

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200608747A UA85578C2 (ru) 2004-02-13 2005-02-14 Микроэмульсионный препарат с высокой концентрацией пропофола для применения в анестезии

Country Status (14)

Country Link
US (2) US8383687B2 (ru)
EP (1) EP1713444A4 (ru)
JP (1) JP5165249B2 (ru)
KR (1) KR20070005617A (ru)
CN (1) CN100479812C (ru)
AU (1) AU2005215517C1 (ru)
BR (1) BRPI0506812B8 (ru)
CA (1) CA2556185C (ru)
EA (1) EA010242B1 (ru)
IL (2) IL177419A (ru)
NZ (1) NZ549016A (ru)
UA (1) UA85578C2 (ru)
WO (1) WO2005079758A1 (ru)
ZA (1) ZA200606947B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0604377A (pt) * 2006-10-27 2008-06-24 Cristalia Prod Quimicos Farm microemulsão óleo/água de propofol estável e pronta-para-uso
WO2008101344A1 (en) * 2007-02-22 2008-08-28 Peter Tomlinson Soluble bioactive lipophilic compounds compositions
AR060926A1 (es) * 2007-05-14 2008-07-23 Ciriaco Quiroga Solucion anestesica transparente de propofol, con baja irritacion venosa.
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
CN101411685B (zh) * 2007-10-19 2011-04-20 上海医药工业研究院 一种静脉麻醉药2,6-二异丙基苯酚微乳组合物及其制备方法
DE112008002914A5 (de) * 2007-11-06 2010-09-30 B. Braun Melsungen Ag Einen hydrophoben Wirkstoff enthaltende wässrige Emulsionen
CN101756900B (zh) * 2010-02-25 2012-05-30 谢恬 一种榄香烯微乳
JP4834775B2 (ja) * 2010-03-04 2011-12-14 株式会社 資生堂 日焼け止め用組成物
WO2016038734A1 (ja) 2014-09-12 2016-03-17 テルモ株式会社 レミフェンタニル注射液剤
JP2017531011A (ja) 2014-10-16 2017-10-19 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 麻酔のための新規の方法、化合物および組成物
US20180098936A1 (en) * 2015-03-23 2018-04-12 President And Fellows Of Harvard College Methods and compositions for injecting high concentration and/or high viscosity active agent solutions
CN108348451B (zh) * 2015-07-01 2023-02-21 耶路撒冷希伯来大学伊森姆研究发展有限公司 用于丙泊酚的递送系统
CN108601732A (zh) * 2015-12-09 2018-09-28 磷肌酸有限公司 药物制剂
RU2742650C2 (ru) * 2015-12-09 2021-02-09 Фосфейдженикс Лимитед Фармацевтический состав
IL267006B2 (en) 2016-12-21 2024-11-01 Phosphagenics Ltd Process for phosphorylation of a complex alcohol with p4o10 at high temperatures, and products thereof
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions
WO2021158575A1 (en) * 2020-02-03 2021-08-12 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules
US11767281B2 (en) 2020-02-06 2023-09-26 Nandkumar Kashinath Chodankar Manufacturing and purification technology for high purity Propofol
WO2022026960A1 (en) 2020-07-31 2022-02-03 Natural Extraction Systems, LLC Compositions and methods related to excipients and cannabinoid formulations
WO2022182523A1 (en) * 2021-02-26 2022-09-01 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405593D0 (en) 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
GB9514878D0 (en) 1995-07-20 1995-09-20 Danbiosyst Uk Vitamin E as a solubilizer for drugs contained in lipid vehicles
SE9503143D0 (sv) 1995-09-12 1995-09-12 Astra Ab New preparation
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
WO1999039696A1 (en) 1998-02-10 1999-08-12 Sicor Inc. Propofol composition containing sulfite
CN100341485C (zh) * 1998-04-01 2007-10-10 斯凯伊药品加拿大公司 抗癌组合物
ATE327741T1 (de) 1999-06-21 2006-06-15 Kuhnil Pharmaceutical Co Ltd Propofol enthaltende anästhetische zusammensetzung zur intravenösen injektion
KR20010055736A (ko) 1999-12-13 2001-07-04 이규현 프로포폴의 마이크로에멀젼 주사제 조성물
GB2359747B (en) * 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
WO2001097779A2 (en) * 2000-06-16 2001-12-27 Rtp Pharma Inc. Improved injectable dispersions of propofol
US6623765B1 (en) * 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
IN188917B (ru) 2000-12-07 2002-11-23 Bharat Surums & Vaccines Ltd
KR100441167B1 (ko) * 2001-12-27 2004-07-21 씨제이 주식회사 마이크로에멀젼 예비 농축액 조성물
KR100482269B1 (ko) * 2002-10-08 2005-04-14 센츄론(주) 2,6-디이소프로필페놀을 활성성분으로 하는 수용액상의마취용 주사제 및 그 제조방법
US7326735B2 (en) 2003-04-30 2008-02-05 Parnell Laboratories (Aust) Pty Limited Formulations for anaesthetic use
KR101055736B1 (ko) * 2008-09-30 2011-08-11 엘지전자 주식회사 김치냉장고

Also Published As

Publication number Publication date
EA200601460A1 (ru) 2007-02-27
JP2007522238A (ja) 2007-08-09
KR20070005617A (ko) 2007-01-10
IL177419A0 (en) 2006-12-10
CN1917858A (zh) 2007-02-21
US8383687B2 (en) 2013-02-26
CN100479812C (zh) 2009-04-22
EP1713444A1 (en) 2006-10-25
IL177419A (en) 2017-01-31
AU2005215517B2 (en) 2009-10-08
AU2005215517C1 (en) 2011-04-14
US20130131186A1 (en) 2013-05-23
BRPI0506812B8 (pt) 2021-05-25
IL247782A0 (en) 2016-11-30
NZ549016A (en) 2012-03-30
ZA200606947B (en) 2008-01-08
BRPI0506812B1 (pt) 2020-12-08
CA2556185A1 (en) 2005-09-01
AU2005215517A1 (en) 2005-09-01
JP5165249B2 (ja) 2013-03-21
CA2556185C (en) 2010-09-21
US20070141090A1 (en) 2007-06-21
EA010242B1 (ru) 2008-06-30
US8962696B2 (en) 2015-02-24
WO2005079758A1 (en) 2005-09-01
EP1713444A4 (en) 2012-06-20
BRPI0506812A (pt) 2007-06-05

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