UA85543C2 - Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных - Google Patents
Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животныхInfo
- Publication number
- UA85543C2 UA85543C2 UAA200502041A UA2005002041A UA85543C2 UA 85543 C2 UA85543 C2 UA 85543C2 UA A200502041 A UAA200502041 A UA A200502041A UA 2005002041 A UA2005002041 A UA 2005002041A UA 85543 C2 UA85543 C2 UA 85543C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cultivation
- composition
- vaccinization
- animals
- amplification
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 241000700605 Viruses Species 0.000 title abstract 4
- 239000005862 Whey Substances 0.000 title abstract 3
- 102000007544 Whey Proteins Human genes 0.000 title abstract 3
- 108010046377 Whey Proteins Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 230000003321 amplification Effects 0.000 title abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 title abstract 2
- 241000271566 Aves Species 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24151—Methods of production or purification of viral material
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к способу амплификации вируса, который включает этапы культивирования первичных птичьих клеток в безсывороточной среде, содержащей фактор, выбранный из группы, которая включает факторы роста (EGF) и факторы адгезии (FN), инфицирования первичных птичьих клеток вирусом, культивирование инфицированных клеток в безсывороточной среде до получения вирусного поколения. Также изобретение относится к композиции и ее применению, которая содержит вирус, полученный заявленным способом, и способу лечения или вакцинации животных, который включает введение указанной выше композиции.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200201302 | 2002-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA85543C2 true UA85543C2 (ru) | 2009-02-10 |
Family
ID=31970216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200502041A UA85543C2 (ru) | 2002-09-05 | 2003-09-01 | Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US7695939B2 (ru) |
| EP (1) | EP1434858B2 (ru) |
| JP (2) | JP2005537793A (ru) |
| KR (1) | KR101044538B1 (ru) |
| CN (1) | CN1692156B (ru) |
| AT (1) | ATE393212T2 (ru) |
| AU (1) | AU2003264144C1 (ru) |
| BR (1) | BRPI0313559B8 (ru) |
| CA (1) | CA2494379C (ru) |
| CY (1) | CY1114598T1 (ru) |
| DE (1) | DE60320520T3 (ru) |
| DK (1) | DK1434858T4 (ru) |
| EA (1) | EA009008B1 (ru) |
| ES (1) | ES2305514T5 (ru) |
| HK (1) | HK1080507B (ru) |
| MX (1) | MXPA04012966A (ru) |
| NO (1) | NO343489B1 (ru) |
| NZ (1) | NZ538575A (ru) |
| PL (1) | PL215169B1 (ru) |
| PT (1) | PT1434858E (ru) |
| SI (1) | SI1434858T2 (ru) |
| UA (1) | UA85543C2 (ru) |
| WO (1) | WO2004022729A1 (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230198B1 (hu) * | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
| US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| WO2004022729A1 (en) | 2002-09-05 | 2004-03-18 | Bavarian Nordic A/S | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions |
| EP1528101A1 (en) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
| HUE030037T2 (en) | 2005-02-23 | 2017-04-28 | Bavarian Nordic As | Use of modified anemic virus for rapid induction of immunity against gluten virus or other agents |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| MX348525B (es) | 2006-06-20 | 2017-06-16 | Transgene Sa | Proceso para producir poxvirus y composiciones de poxvirus. |
| RU2012106760A (ru) | 2009-07-21 | 2013-08-27 | Трансген Са | Ферментативная композиция для ферментативного расщепления куриного эмбриона |
| US20130164329A1 (en) * | 2010-02-17 | 2013-06-27 | Alnylam Pharmaceuticals, Inc. | Cell-based methods and reagents |
| JP2013523175A (ja) | 2010-04-14 | 2013-06-17 | イーエムディー・ミリポア・コーポレーション | 高力価、高純度のウイルスストックの作製方法及びその使用方法 |
| CA2802430C (en) * | 2010-07-20 | 2021-07-20 | Bavarian Nordic A/S | Method for harvesting poxvirus |
| KR101504159B1 (ko) * | 2012-04-20 | 2015-03-19 | 한국생명공학연구원 | 미세조류의 성장을 촉진하는 엑소피아라 올리고스퍼마 및 이의 용도 |
| SG11201609980TA (en) * | 2014-06-18 | 2016-12-29 | Medimmune Llc | Cell culture methods and media comprising n-acetylcysteine |
| KR101677231B1 (ko) | 2014-12-18 | 2016-11-30 | 제주대학교 산학협력단 | 무혈청배지(serum free medium)를 이용한 메갈로사이티바이러스의 효율적 제조방법 |
| CN105462911B (zh) * | 2015-12-22 | 2018-04-13 | 肇庆大华农生物药品有限公司 | 用于培养病毒的无血清培养液及其制备方法 |
| CN107129963A (zh) * | 2017-04-24 | 2017-09-05 | 浙江美保龙生物技术有限公司 | 一种df‑1细胞培养液添加剂及其制备方法、使用方法 |
| WO2018211419A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| US11306292B2 (en) | 2017-05-15 | 2022-04-19 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| SG11202101291VA (en) | 2018-08-08 | 2021-03-30 | Univ Arizona State | Method for improved poxvirus yields |
| AU2019336940B2 (en) | 2018-09-06 | 2025-09-11 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| CN113355297A (zh) * | 2021-06-23 | 2021-09-07 | 吉林冠界生物技术有限公司 | 一种灌流式培养全悬浮mdck细胞生产重组禽流感病毒的方法 |
| AU2023298083A1 (en) | 2022-06-29 | 2025-01-09 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
| JP2025524459A (ja) | 2022-06-29 | 2025-07-30 | バヴァリアン・ノルディック・アクティーゼルスカブ | エプスタイン・バー・ウイルスワクチン |
| CN116656628A (zh) * | 2023-07-31 | 2023-08-29 | 深圳市卫光生物制品股份有限公司 | 一种痘病毒载体疫苗的制备方法 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2004402A (en) * | 1934-04-07 | 1935-06-11 | Conklin John Edward | Atomizer |
| US3887430A (en) | 1972-02-24 | 1975-06-03 | Dow Chemical Co | Culture medium for tissue culture techniques |
| US4072565A (en) | 1974-11-04 | 1978-02-07 | The Dow Chemical Company | Production of viruses in tissue culture without use of serum |
| US3914408A (en) | 1973-10-12 | 1975-10-21 | Univ Nebraska | Vaccine for neonatal calf diarrhea |
| DE2714665A1 (de) | 1977-04-01 | 1978-10-05 | Mayr Anton | Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung |
| US5155020A (en) | 1989-03-08 | 1992-10-13 | Health Research Inc. | Recombinant poxvirus host range selection system |
| US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| AU613583B2 (en) | 1986-08-22 | 1991-08-08 | Transgene S.A. | Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity |
| US5024947A (en) * | 1987-07-24 | 1991-06-18 | Cetus Corporation | Serum free media for the growth on insect cells and expression of products thereby |
| CA1341245C (en) * | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| US6248333B1 (en) | 1990-04-04 | 2001-06-19 | Health Research Inc. | Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD) |
| AT393277B (de) | 1990-01-04 | 1991-09-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen |
| EP0550638A4 (en) * | 1990-09-25 | 1993-12-08 | Smithkline Beecham Corporation | Medium for culture of mammalian cells |
| AU672359B2 (en) | 1991-03-07 | 1996-10-03 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US5766598A (en) | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
| US5843456A (en) | 1991-03-07 | 1998-12-01 | Virogenetics Corporation | Alvac poxvirus-rabies compositions and combination compositions and uses |
| IL102929A (en) | 1992-08-24 | 1996-11-14 | Interpharm Lab Ltd | Serum-free medium for mammalian cells |
| US5403582A (en) | 1993-01-21 | 1995-04-04 | Nippon Zeon Co., Ltd. | Vaccine comprising fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus |
| US5405772A (en) | 1993-06-18 | 1995-04-11 | Amgen Inc. | Medium for long-term proliferation and development of cells |
| US5768598A (en) | 1993-09-13 | 1998-06-16 | Intel Corporation | Method and apparatus for sharing hardward resources in a computer system |
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US6190655B1 (en) | 1993-12-03 | 2001-02-20 | Immunex Corporation | Methods of using Flt-3 ligand for exogenous gene transfer |
| DE4405841C1 (de) * | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CA2188447C (en) | 1994-04-29 | 2002-10-22 | Falko-Gunter Falkner | Recombinant poxviruses with foreign polynucleotides in essential regions |
| US5756341A (en) * | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| ES2323490T3 (es) | 1994-11-10 | 2009-07-17 | Baxter Healthcare Sa | Procedimiento de produccion de agentes biologicos en un medio de cultivo sin proteinas. |
| US6146873A (en) | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5503582A (en) | 1994-11-18 | 1996-04-02 | Micron Display Technology, Inc. | Method for forming spacers for display devices employing reduced pressures |
| UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| JPH09154571A (ja) * | 1995-12-05 | 1997-06-17 | Kurabo Ind Ltd | ウイルス製造用無血清培地 |
| DE69739372D1 (de) | 1996-02-21 | 2009-06-04 | Immunity Kft. Genetic | Verfahren und zusammensetzungen zur genetisch schützenden und therapeutischen immunisierung |
| AU3813597A (en) | 1996-07-26 | 1998-02-20 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
| MY150893A (en) | 1996-09-24 | 2014-03-14 | Bavarian Nordic As | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
| US6103529A (en) | 1996-10-10 | 2000-08-15 | Life Technologies, Inc. | Animal cell culture media comprising peptides derived from rice |
| AU5091898A (en) | 1996-10-25 | 1998-05-15 | Wistar Institute Of Anatomy And Biology, The | Method of vaccinating infants against infections |
| US6204250B1 (en) | 1996-11-22 | 2001-03-20 | The Mount Sinai Medical Center Of The City Of New York | Immunization of infants |
| WO2000029428A2 (en) | 1998-11-18 | 2000-05-25 | Oxford Biomedica (Uk) Limited | 5t4 tumour-associated antigen for use in tumour immunotherapy |
| GB0023203D0 (en) | 2000-09-21 | 2000-11-01 | Isis Innovation | Vaccination method |
| US20030138454A1 (en) | 1997-06-09 | 2003-07-24 | Oxxon Pharmaccines, Ltd. | Vaccination method |
| GB9711957D0 (en) | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| AT407255B (de) | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| AU3910097A (en) | 1997-08-05 | 1999-03-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Live recombinant vaccine comprising inefficiently or non-replicating vir us |
| EP1019513A1 (en) * | 1998-08-04 | 2000-07-19 | Immunex Corporation | Ikr-1 and ikr-2, protein kinases which are related to the i kappa b kinases |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| DE69839970D1 (de) | 1998-11-10 | 2008-10-16 | Univ Rochester | Methoden zu herstellung von genbanken |
| GB2370571B (en) | 1998-11-18 | 2003-05-07 | Oxford Biomedica Ltd | A modified 5t4 antigen |
| US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
| DE19935351A1 (de) | 1999-07-29 | 2001-02-01 | Abb Daimler Benz Transp | Verfahren zur Energieoptimierung bei einem Fahrzeug/Zug mit arbeitspunktabhängigem Wirkungsgrad |
| EE05633B1 (et) | 2000-03-14 | 2013-02-15 | Mayr Anton | Muundatud vaktsiiniaviirus Ankara (MVA), sellega nakatatud peremeesrakk ning seda sisaldav farmatseutiline kompositsioon, MVA valmistamine ja raviotstarbeline kasutamine |
| WO2001089559A2 (en) | 2000-05-24 | 2001-11-29 | Merial | Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine |
| WO2002004002A2 (de) | 2000-07-11 | 2002-01-17 | Bayer Aktiengesellschaft | Verwendung von stämmen des parapoxvirus ovis zur herstellung von antiviralen arzneimitteln und arzneimitteln gegen krebs |
| EP1358319B1 (en) * | 2000-09-25 | 2009-06-17 | Polymun Scientific Immunbiologische Forschung GmbH | Live influenza vaccine and method of manufacture |
| US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| US7097842B2 (en) | 2000-11-23 | 2006-08-29 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
| WO2004022729A1 (en) | 2002-09-05 | 2004-03-18 | Bavarian Nordic A/S | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions |
| HU230198B1 (hu) | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
| UA82466C2 (ru) * | 2001-07-18 | 2008-04-25 | Бавариан Нордика А/С | Способ усиления амплификации хордопоксвируса |
| AU2002356690B2 (en) | 2001-12-04 | 2008-07-24 | Bavarian Nordic A/S | Flavivirus NS1 subunit vaccine |
| US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| CA2467365C (en) | 2001-12-10 | 2012-11-20 | Bavarian Nordic A/S | Poxvirus containing formulations and process for preparing stable, poxvirus containing compositions |
| DK1407006T3 (da) * | 2001-12-20 | 2005-12-12 | Bavarian Nordic As | Fremgangsmåde til indvinding og oprensning af poxvirus fra inficerede celler |
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| WO2003078640A2 (en) | 2002-03-15 | 2003-09-25 | Baxter International Inc. | Recombinant drug-sensitive vaccinia virus as smallpox vaccine |
| PL218318B1 (pl) | 2002-05-16 | 2014-11-28 | Bavarian Nordic As | Rekombinowany wirus krowianki Ankara (MVA), zawierająca go komórka, szczepionka lub kompozycja farmaceutyczna, sposób lub zestaw do jego otrzymywania, sekwencja DNA zawierająca genom tego wirusa oraz sposób wykrywania tego wirusa lub komórek nim zainfekowanych |
| WO2003097844A1 (en) | 2002-05-16 | 2003-11-27 | Bavarian Nordic A/S | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| DE602004027141D1 (de) | 2003-07-22 | 2010-06-24 | Vivalis | Produktion von poxviren mit adhärenten oder nicht adhärenten vogelzellinien |
| US6915752B2 (en) * | 2003-09-30 | 2005-07-12 | Lockheed Martin Corporation | Utility service protection strip |
| US6976752B2 (en) | 2003-10-28 | 2005-12-20 | Lexmark International, Inc. | Ink jet printer with resistance compensation circuit |
-
2003
- 2003-09-01 WO PCT/EP2003/009704 patent/WO2004022729A1/en not_active Ceased
- 2003-09-01 NZ NZ538575A patent/NZ538575A/en not_active IP Right Cessation
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- 2003-09-01 EP EP03766057.8A patent/EP1434858B2/en not_active Expired - Lifetime
- 2003-09-01 UA UAA200502041A patent/UA85543C2/ru unknown
- 2003-09-01 EA EA200500448A patent/EA009008B1/ru not_active IP Right Cessation
- 2003-09-01 KR KR1020057000155A patent/KR101044538B1/ko not_active Expired - Lifetime
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- 2003-09-01 BR BRPI0313559A patent/BRPI0313559B8/pt active IP Right Grant
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