UA84035C2 - Производные феноксиуксусных кислот, полезные как двойные агонисты активированных рецепторов пероксисомального пролифератора (ppar) - Google Patents
Производные феноксиуксусных кислот, полезные как двойные агонисты активированных рецепторов пероксисомального пролифератора (ppar)Info
- Publication number
- UA84035C2 UA84035C2 UAA200605139A UAA200605139A UA84035C2 UA 84035 C2 UA84035 C2 UA 84035C2 UA A200605139 A UAA200605139 A UA A200605139A UA A200605139 A UAA200605139 A UA A200605139A UA 84035 C2 UA84035 C2 UA 84035C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ppar
- activated receptor
- peroxisome proliferator
- derivatives useful
- phenoxyacetic acids
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title abstract 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title abstract 2
- LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical class OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 title abstract 2
- 101150014691 PPARA gene Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51656103P | 2003-10-31 | 2003-10-31 | |
| PCT/US2004/036028 WO2005041959A1 (en) | 2003-10-31 | 2004-10-28 | Phenoxyacetic acids derivatives useful as peroxisome proliferator-activated receptor (ppar) dual agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA84035C2 true UA84035C2 (ru) | 2008-09-10 |
Family
ID=34549548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200605139A UA84035C2 (ru) | 2003-10-31 | 2004-10-28 | Производные феноксиуксусных кислот, полезные как двойные агонисты активированных рецепторов пероксисомального пролифератора (ppar) |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7015329B2 (ru) |
| EP (1) | EP1684752B1 (ru) |
| JP (1) | JP2007527416A (ru) |
| KR (1) | KR20060109925A (ru) |
| CN (1) | CN1897939A (ru) |
| AR (1) | AR046311A1 (ru) |
| AT (1) | ATE362367T1 (ru) |
| AU (1) | AU2004285530A1 (ru) |
| BR (1) | BRPI0416106A (ru) |
| CA (1) | CA2544317A1 (ru) |
| CR (1) | CR8377A (ru) |
| DE (1) | DE602004006529T2 (ru) |
| EA (1) | EA009804B1 (ru) |
| EC (1) | ECSP066536A (ru) |
| ES (1) | ES2287786T3 (ru) |
| IL (1) | IL175310A0 (ru) |
| NO (1) | NO20062511L (ru) |
| TW (1) | TW200528438A (ru) |
| UA (1) | UA84035C2 (ru) |
| WO (1) | WO2005041959A1 (ru) |
| ZA (1) | ZA200604420B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1667964T3 (pl) | 2003-09-19 | 2010-01-29 | Janssen Pharmaceutica Nv | Kwasy 4-((fenoksyalkilo)tio)-fenoksyoctowe i analogi |
| ES2287786T3 (es) * | 2003-10-31 | 2007-12-16 | Janssen Pharmaceutica N.V. | Derivados de acido fenoxiacetico utiles como agonistas dobles del receptor activado por el proliferador de peroxisomas (ppar). |
| WO2006042245A1 (en) * | 2004-10-11 | 2006-04-20 | Dr. Reddy's Laboratories Ltd. | Novel isoxazole compounds having ppar agonist activity |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| UY30288A1 (es) * | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
| JP5864077B2 (ja) | 2006-09-08 | 2016-02-17 | ロード アイランド ホスピタル | アルコール誘発性肝疾患の治療、予防および回復 |
| EP2061442B1 (en) | 2006-09-08 | 2016-08-31 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
| MX2009010854A (es) | 2007-04-11 | 2010-01-28 | Omeros Corp | Composiciones y metodos para profilaxis y tratamiento de adicciones. |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| EP2310371B1 (fr) | 2008-05-26 | 2013-05-15 | Genfit | Composés agonistes ppar, préparation et utilisations pour le traitement du diabète et/ou des dyslipidémies |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
| WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
| CN103270029B (zh) | 2010-10-22 | 2016-01-20 | 拜耳知识产权有限责任公司 | 作为农药的杂环化合物 |
| BR112014026643B1 (pt) | 2012-04-26 | 2023-03-07 | Universite De Montreal | Derivados de imidazotiadiazol e imidazopirazina como inibidores de receptor 4 ativado por protease (par4) para o tratamento de agregação de plaqueta, seus usos e composição farmacêutica |
| CA2871640A1 (en) | 2012-04-26 | 2013-10-31 | Bristol-Myers Squibb Company | Par4 agonist peptides |
| CN118359543A (zh) * | 2023-01-18 | 2024-07-19 | 哈尔滨三联药业股份有限公司 | 五元杂环类化合物及其医药用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506757B1 (en) * | 1998-03-10 | 2003-01-14 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| US6242493B1 (en) | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| AU4167099A (en) | 1998-06-19 | 2000-01-05 | Nissan Chemical Industries Ltd. | Heterocyclic compounds as hypoglycemic agents |
| AUPP609198A0 (en) | 1998-09-22 | 1998-10-15 | Curtin University Of Technology | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| RU2267484C2 (ru) | 1999-04-28 | 2006-01-10 | Авентис Фарма Дойчланд Гмбх | Производные диариловой кислоты и фармацевтическая композиция на их основе |
| CA2371308A1 (en) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| AU7073400A (en) * | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| AU2001277723A1 (en) * | 2000-08-11 | 2002-02-25 | Nippon Chemiphar Co., Ltd. | Ppardelta activators |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| CA2510793A1 (en) * | 2002-12-20 | 2004-07-15 | Bayer Pharmaceuticals Corporation | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| ES2287786T3 (es) * | 2003-10-31 | 2007-12-16 | Janssen Pharmaceutica N.V. | Derivados de acido fenoxiacetico utiles como agonistas dobles del receptor activado por el proliferador de peroxisomas (ppar). |
-
2004
- 2004-10-28 ES ES04796767T patent/ES2287786T3/es not_active Expired - Lifetime
- 2004-10-28 WO PCT/US2004/036028 patent/WO2005041959A1/en not_active Ceased
- 2004-10-28 US US10/975,785 patent/US7015329B2/en not_active Expired - Fee Related
- 2004-10-28 AT AT04796767T patent/ATE362367T1/de not_active IP Right Cessation
- 2004-10-28 DE DE602004006529T patent/DE602004006529T2/de not_active Expired - Fee Related
- 2004-10-28 KR KR1020067010610A patent/KR20060109925A/ko not_active Withdrawn
- 2004-10-28 EP EP04796767A patent/EP1684752B1/en not_active Expired - Lifetime
- 2004-10-28 EA EA200600878A patent/EA009804B1/ru not_active IP Right Cessation
- 2004-10-28 BR BRPI0416106-8A patent/BRPI0416106A/pt not_active IP Right Cessation
- 2004-10-28 CA CA002544317A patent/CA2544317A1/en not_active Abandoned
- 2004-10-28 AU AU2004285530A patent/AU2004285530A1/en not_active Abandoned
- 2004-10-28 UA UAA200605139A patent/UA84035C2/ru unknown
- 2004-10-28 JP JP2006538316A patent/JP2007527416A/ja not_active Withdrawn
- 2004-10-28 CN CNA2004800382161A patent/CN1897939A/zh active Pending
- 2004-10-29 AR ARP040103979A patent/AR046311A1/es not_active Application Discontinuation
- 2004-10-29 TW TW093132849A patent/TW200528438A/zh unknown
-
2005
- 2005-11-15 US US11/274,656 patent/US7498351B2/en not_active Expired - Fee Related
-
2006
- 2006-04-27 IL IL175310A patent/IL175310A0/en unknown
- 2006-04-28 EC EC2006006536A patent/ECSP066536A/es unknown
- 2006-05-02 CR CR8377A patent/CR8377A/es unknown
- 2006-05-30 ZA ZA200604420A patent/ZA200604420B/en unknown
- 2006-05-31 NO NO20062511A patent/NO20062511L/no not_active Application Discontinuation
-
2009
- 2009-01-23 US US12/358,703 patent/US20090131489A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200528438A (en) | 2005-09-01 |
| DE602004006529T2 (de) | 2008-01-31 |
| EP1684752B1 (en) | 2007-05-16 |
| ECSP066536A (es) | 2006-12-20 |
| CA2544317A1 (en) | 2005-05-12 |
| US20060074246A1 (en) | 2006-04-06 |
| NO20062511L (no) | 2006-07-27 |
| ZA200604420B (en) | 2007-10-31 |
| AU2004285530A1 (en) | 2005-05-12 |
| BRPI0416106A (pt) | 2007-01-02 |
| DE602004006529D1 (de) | 2007-06-28 |
| AR046311A1 (es) | 2005-11-30 |
| CR8377A (es) | 2008-11-24 |
| US7498351B2 (en) | 2009-03-03 |
| US20090131489A1 (en) | 2009-05-21 |
| US20050096362A1 (en) | 2005-05-05 |
| KR20060109925A (ko) | 2006-10-23 |
| EP1684752A1 (en) | 2006-08-02 |
| US7015329B2 (en) | 2006-03-21 |
| ATE362367T1 (de) | 2007-06-15 |
| EA200600878A1 (ru) | 2006-10-27 |
| WO2005041959A1 (en) | 2005-05-12 |
| JP2007527416A (ja) | 2007-09-27 |
| EA009804B1 (ru) | 2008-04-28 |
| ES2287786T3 (es) | 2007-12-16 |
| IL175310A0 (en) | 2006-09-05 |
| CN1897939A (zh) | 2007-01-17 |
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