UA8019A1 - Method for synthesizing 2-(2,4-difluorophenyl)-1,3-bis-(1н-1,2,4-triazol-1-yl)-propane-2-ol or its pharmaceutically acceptable salt - Google Patents
Method for synthesizing 2-(2,4-difluorophenyl)-1,3-bis-(1н-1,2,4-triazol-1-yl)-propane-2-ol or its pharmaceutically acceptable saltInfo
- Publication number
- UA8019A1 UA8019A1 UA3450435A UA3450435A UA8019A1 UA 8019 A1 UA8019 A1 UA 8019A1 UA 3450435 A UA3450435 A UA 3450435A UA 3450435 A UA3450435 A UA 3450435A UA 8019 A1 UA8019 A1 UA 8019A1
- Authority
- UA
- Ukraine
- Prior art keywords
- triazol
- pharmaceutically acceptable
- acceptable salt
- difluorophenyl
- synthesizing
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The invention consists in the method for synthesizing 2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)-propane-2-ol of the formula or its pharmaceutically acceptable salt. 1,2,4-triazol reacts at the temperature of 50-120°C in the presence of the base with the compound of the general formula where R-OH; X and Y each represents halogen or R and X together represent oxygen, and Y is a following radical followed by the separation of the end product in the free form or as the pharmaceutically acceptable salt.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8206329 | 1982-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA8019A1 true UA8019A1 (en) | 1995-12-26 |
Family
ID=10528771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA3450435A UA8019A1 (en) | 1982-03-04 | 1982-06-01 | Method for synthesizing 2-(2,4-difluorophenyl)-1,3-bis-(1н-1,2,4-triazol-1-yl)-propane-2-ol or its pharmaceutically acceptable salt |
Country Status (2)
| Country | Link |
|---|---|
| SU (1) | SU1306474A3 (en) |
| UA (1) | UA8019A1 (en) |
-
1982
- 1982-06-01 SU SU823450435A patent/SU1306474A3/en active
- 1982-06-01 UA UA3450435A patent/UA8019A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU1306474A3 (en) | 1987-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU42770B (en) | Process for obtaining 2-(2,4-difluorophenyl)-1,3-bis-(1h-1,2,4-triazol-1-yl)propane-2-oles | |
| IE42064L (en) | Triazole derivatives | |
| CY1251A (en) | Heterocyclic derivatives of(4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1h-imidazoles and 1h-1,2,4-triazoles,processes for preparing them,compositions containing them and their use for combating the growth of microorganisms | |
| YU42196B (en) | Process for obtaining new derivatives of 1h-1,2,4-triazole | |
| AU543946B2 (en) | Derivatives of 4h-1,2,4-triazole | |
| IE832184L (en) | Derivatives of imidazole and 1, 2, 4-triazole. | |
| ES8204427A1 (en) | Geometrical isomers of 4,4-dimethyl-1-phenyl-2-(1,2,4-triazole-1-yl)-1-penten-3-ols, process for their preparation and medicament containing them. | |
| IL62332A (en) | Antimycotic compositions comprising 1,1-diphenyl-2-(1,2,4-triazol-1-yl)-ethan-1-ols,a certain such compound and its preparation | |
| IE810431L (en) | Triazoles. | |
| JPS57181069A (en) | Delta2-1,2,4-triazolin-5-one and its preparation and use | |
| AU539189B2 (en) | 1h-1,2,4-triazole derivatives | |
| UA8019A1 (en) | Method for synthesizing 2-(2,4-difluorophenyl)-1,3-bis-(1н-1,2,4-triazol-1-yl)-propane-2-ol or its pharmaceutically acceptable salt | |
| AU558860B2 (en) | 2-aryl-2-azolymethyl-1,3-dioxepines | |
| ES2009921A6 (en) | Imidazole derivatives and a process for the preparation thereof | |
| EP0062236A3 (en) | Fungicidal agent containing triazole derivatives, and process for combating fungi therewith | |
| ATE170178T1 (en) | PRODUCTION OF 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | |
| DE3270398D1 (en) | 5-aryloxy-5-azolyl-3,3-dimethyl-1-penten-4-ones and -ols, process for their preparation and their use as fungicides | |
| HRP930368B1 (en) | Process for the preparation of 2-(2,4-difluorophenyl)-1,3-bis-(1h-1,2,4-triazole-1-il)-propan-2-oles | |
| EP0269308A3 (en) | Process for the synthesis of 4-amino-1,2,4-(4h)triazole derivatives | |
| ZA889070B (en) | Novel azole compounds | |
| ZA828491B (en) | Alkylcycloalkyl imidazolylmethyl ketones and a process for their preparation | |
| EP0515876A3 (en) | Process for the preparation of cis-2-(1h-1,2,4-triazol-1-yl-methyl)2-(halophenyl)-3-(halophenyl)-oxirane | |
| JPS5764662A (en) | Alkylene disulfur derivative | |
| ES8506700A1 (en) | (5-(2-Aminomethyl-imidazol-1-yl)-1,3-dialkyl-1H-pyrazol-4-yl)(aryl)methanones and processes for their production. | |
| PT71460B (en) | Process for the preparation of novel 1,2,4-triazol derivatives and fungicidal compositions thereof |