UA61968C2 - Pharmaceutical compositions containing vitamin d and calcium, their manufacture and therapeutic use - Google Patents

Pharmaceutical compositions containing vitamin d and calcium, their manufacture and therapeutic use Download PDF

Info

Publication number: UA61968C2
Authority: UA; Ukraine
Prior art keywords: vitamin; composition according; pharmaceutical composition; calcium; propylene glycol
Prior art date: 1997-07-30

Application number

UA2000021176A

Other languages

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-30

Filing date

1998-07-21

Publication date

2003-12-15

1998-07-21 Application filed filed Critical

2003-12-15 Publication of UA61968C2 publication Critical patent/UA61968C2/uk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 25
239000011575 calcium Substances 0.000 title claims abstract description 19
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 13
229910052791 calcium Inorganic materials 0.000 title claims abstract description 12
229940046008 vitamin d Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title description 2
230000001225 therapeutic effect Effects 0.000 title description 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 37
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 11
229920002545 silicone oil Polymers 0.000 claims abstract description 9
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
238000011282 treatment Methods 0.000 claims abstract description 8
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 6
239000011230 binding agent Substances 0.000 claims abstract description 5
208000002720 Malnutrition Diseases 0.000 claims abstract description 4
235000018343 nutrient deficiency Nutrition 0.000 claims abstract description 4
239000011782 vitamin Substances 0.000 claims description 38
229940088594 vitamin Drugs 0.000 claims description 38
229930003231 vitamin Natural products 0.000 claims description 38
235000013343 vitamin Nutrition 0.000 claims description 38
150000003722 vitamin derivatives Chemical class 0.000 claims description 38
239000000203 mixture Substances 0.000 claims description 30
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 19
159000000007 calcium salts Chemical class 0.000 claims description 15
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 15
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 13
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
229940075614 colloidal silicon dioxide Drugs 0.000 claims description 9
239000008187 granular material Substances 0.000 claims description 9
235000005282 vitamin D3 Nutrition 0.000 claims description 9
239000011647 vitamin D3 Substances 0.000 claims description 9
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 9
229940021056 vitamin d3 Drugs 0.000 claims description 9
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
229930195725 Mannitol Natural products 0.000 claims description 8
239000000594 mannitol Substances 0.000 claims description 8
235000010355 mannitol Nutrition 0.000 claims description 8
235000019731 tricalcium phosphate Nutrition 0.000 claims description 8
239000001506 calcium phosphate Substances 0.000 claims description 7
229910000389 calcium phosphate Inorganic materials 0.000 claims description 7
235000011010 calcium phosphates Nutrition 0.000 claims description 7
229940079593 drug Drugs 0.000 claims description 7
239000003814 drug Substances 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
235000019640 taste Nutrition 0.000 claims description 7
235000019271 petrolatum Nutrition 0.000 claims description 6
235000005979 Citrus limon Nutrition 0.000 claims description 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
208000001132 Osteoporosis Diseases 0.000 claims description 5
210000000988 bone and bone Anatomy 0.000 claims description 5
239000008108 microcrystalline cellulose Substances 0.000 claims description 5
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
239000000600 sorbitol Substances 0.000 claims description 5
235000010356 sorbitol Nutrition 0.000 claims description 5
244000131522 Citrus pyriformis Species 0.000 claims description 4
XZAGBDSOKNXTDT-UHFFFAOYSA-N Sucrose monopalmitate Chemical compound CCCCCCCCCCCCCCCC(O)=O.OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(CO)O1 XZAGBDSOKNXTDT-UHFFFAOYSA-N 0.000 claims description 4
ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 claims description 4
229960004106 citric acid Drugs 0.000 claims description 4
210000000689 upper leg Anatomy 0.000 claims description 4
229910019142 PO4 Inorganic materials 0.000 claims description 3
229960004543 anhydrous citric acid Drugs 0.000 claims description 3
239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
239000003246 corticosteroid Substances 0.000 claims description 3
239000000796 flavoring agent Substances 0.000 claims description 3
235000019634 flavors Nutrition 0.000 claims description 3
239000003921 oil Substances 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
239000010452 phosphate Substances 0.000 claims description 3
229940099259 vaseline Drugs 0.000 claims description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
229940001468 citrate Drugs 0.000 claims description 2
229940050410 gluconate Drugs 0.000 claims description 2
229940001447 lactate Drugs 0.000 claims description 2
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 2
239000000375 suspending agent Substances 0.000 claims description 2
229940095064 tartrate Drugs 0.000 claims description 2
MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
235000015165 citric acid Nutrition 0.000 claims 1
229960002061 ergocalciferol Drugs 0.000 claims 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
235000001892 vitamin D2 Nutrition 0.000 claims 1
239000011653 vitamin D2 Substances 0.000 claims 1
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 1
229930003316 Vitamin D Natural products 0.000 abstract 2
235000019166 vitamin D Nutrition 0.000 abstract 2
239000011710 vitamin D Substances 0.000 abstract 2
150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
229940057995 liquid paraffin Drugs 0.000 abstract 1
239000002552 dosage form Substances 0.000 description 11
239000001913 cellulose Substances 0.000 description 6
235000010980 cellulose Nutrition 0.000 description 6
229920002678 cellulose Polymers 0.000 description 6
230000000694 effects Effects 0.000 description 5
239000004173 sunset yellow FCF Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
238000009826 distribution Methods 0.000 description 3
239000000945 filler Substances 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
239000011734 sodium Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000000126 substance Substances 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
230000003913 calcium metabolism Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
239000000843 powder Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
238000009827 uniform distribution Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
239000004135 Bone phosphate Substances 0.000 description 1
244000248349 Citrus limon Species 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
YDBYJHTYSHBBAU-YFKPBYRVSA-N S-methyl-L-methioninate Chemical compound C[S+](C)CC[C@H](N)C([O-])=O YDBYJHTYSHBBAU-YFKPBYRVSA-N 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000006806 disease prevention Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
239000003906 humectant Substances 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
238000011866 long-term treatment Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
239000007968 orange flavor Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
235000019614 sour taste Nutrition 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Inorganic Chemistry (AREA)
Vascular Medicine (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UA2000021176A 1997-07-30 1998-07-21 Pharmaceutical compositions containing vitamin d and calcium, their manufacture and therapeutic use UA61968C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97FI000184A ITFI970184A1 (it)	1997-07-30	1997-07-30	Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico
PCT/EP1998/004567 WO1999006051A1 (fr)	1997-07-30	1998-07-21	Compositions pharmaceutiques contenant de la vitamine d et du calcium, leur preparation et leur utilisation therapeutique

Publications (1)

Publication Number	Publication Date
UA61968C2 true UA61968C2 (en)	2003-12-15

Family

ID=11352223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000021176A UA61968C2 (en)	1997-07-30	1998-07-21	Pharmaceutical compositions containing vitamin d and calcium, their manufacture and therapeutic use

Country Status (28)

Country	Link
US (1)	US7067154B1 (fr)
EP (1)	EP0999843B1 (fr)
JP (1)	JP4497496B2 (fr)
KR (1)	KR100573421B1 (fr)
AT (1)	ATE271387T1 (fr)
AU (1)	AU8978198A (fr)
BG (1)	BG65044B1 (fr)
BR (1)	BR9810832B1 (fr)
CA (1)	CA2299420C (fr)
CZ (1)	CZ297670B6 (fr)
DE (1)	DE69825164D1 (fr)
EA (1)	EA002492B1 (fr)
EE (1)	EE04046B1 (fr)
ES (1)	ES2223135T3 (fr)
HU (1)	HU226112B1 (fr)
ID (1)	ID23504A (fr)
IL (1)	IL134268A0 (fr)
IS (1)	IS5359A (fr)
IT (1)	ITFI970184A1 (fr)
NO (1)	NO20000310D0 (fr)
PL (1)	PL189295B1 (fr)
PT (1)	PT999843E (fr)
RS (1)	RS49703B (fr)
SI (1)	SI0999843T1 (fr)
SK (1)	SK284873B6 (fr)
TR (1)	TR200000261T2 (fr)
UA (1)	UA61968C2 (fr)
WO (1)	WO1999006051A1 (fr)

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DE602006001295D1 (de)	2005-02-03	2008-07-03	Nycomed Pharma As	Schmelzgranulation einer zusammensetzung mit einer calziumhaltigen verbindung
CA2624897C (fr) *	2005-10-12	2017-02-14	Proventiv Therapeutics, Llc	Procedes et articles servant a traiter l'insuffisance et la deficience en 25-hydroxyvitamine d
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UA95093C2 (uk) *	2005-12-07	2011-07-11	Нікомед Фарма Ас	Спосіб одержання кальцієвмісної сполуки
MXPA05014091A (es) *	2005-12-20	2007-06-20	Leopoldo De Jesus Espinosa Abdala	Composiciones farmaceuticas que comprenden derivados de esteroides sinteticos, minerales y el metabolito activo de la vitamina d, 1,25(oh)2d3 (calcitriol) para la prevencion y tratamiento de la osteoporosis y el control de los sintomas de la menopaus
CA2587805C (fr)	2007-04-25	2014-02-18	The Procter & Gamble Company	Uniformite amelioree de contenu de vitamine d dans des formes dosifiees pharmaceutiques
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TR200900880A2 (tr)	2009-02-05	2010-08-23	Bi̇lgi̇ç Mahmut	Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
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WO2015020191A1 (fr) *	2013-08-09	2015-02-12	日東薬品工業株式会社	Agent calcique
CN105166935B (zh) *	2015-09-01	2018-08-31	张伟	一种含有维生素d3的液体制剂及其制备方法
US11648201B2 (en)	2018-05-02	2023-05-16	Ferring B.V.	Pharmaceutical formulations
KR102211287B1 (ko) *	2018-12-21	2021-02-03	(주)휴온스	비타민 d 또는 이의 유도체를 포함하는 안정성이 개선된 액상 제제
MX2023010739A (es) *	2021-03-12	2023-09-20	Nicoventures Trading Ltd	Productos orales con sistema autoemulsificante.
WO2025079114A1 (fr) *	2023-10-13	2025-04-17	Vytals Wellbeing India Pvt. Ltd.	Formulation de médicament auto-nano-émulsifiant pour cholécalciférol

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1997
- 1997-07-30 IT IT97FI000184A patent/ITFI970184A1/it unknown
1998
- 1998-07-21 US US09/463,586 patent/US7067154B1/en not_active Expired - Fee Related
- 1998-07-21 PL PL98338237A patent/PL189295B1/pl not_active IP Right Cessation
- 1998-07-21 KR KR1020007000898A patent/KR100573421B1/ko not_active Expired - Fee Related
- 1998-07-21 JP JP2000504864A patent/JP4497496B2/ja not_active Expired - Fee Related
- 1998-07-21 BR BRPI9810832-8A patent/BR9810832B1/pt not_active IP Right Cessation
- 1998-07-21 ES ES98941395T patent/ES2223135T3/es not_active Expired - Lifetime
- 1998-07-21 EA EA200000181A patent/EA002492B1/ru not_active IP Right Cessation
- 1998-07-21 EP EP98941395A patent/EP0999843B1/fr not_active Expired - Lifetime
- 1998-07-21 SK SK80-2000A patent/SK284873B6/sk not_active IP Right Cessation
- 1998-07-21 AT AT98941395T patent/ATE271387T1/de active
- 1998-07-21 AU AU89781/98A patent/AU8978198A/en not_active Abandoned
- 1998-07-21 RS YUP-37/00A patent/RS49703B/sr unknown
- 1998-07-21 TR TR2000/00261T patent/TR200000261T2/xx unknown
- 1998-07-21 ID IDW20000401A patent/ID23504A/id unknown
- 1998-07-21 UA UA2000021176A patent/UA61968C2/uk unknown
- 1998-07-21 SI SI9830702T patent/SI0999843T1/xx unknown
- 1998-07-21 DE DE69825164T patent/DE69825164D1/de not_active Expired - Fee Related
- 1998-07-21 CZ CZ20000199A patent/CZ297670B6/cs not_active IP Right Cessation
- 1998-07-21 IL IL13426898A patent/IL134268A0/xx not_active IP Right Cessation
- 1998-07-21 WO PCT/EP1998/004567 patent/WO1999006051A1/fr not_active Ceased
- 1998-07-21 HU HU0100539A patent/HU226112B1/hu not_active IP Right Cessation
- 1998-07-21 CA CA002299420A patent/CA2299420C/fr not_active Expired - Fee Related
- 1998-07-21 PT PT98941395T patent/PT999843E/pt unknown
- 1998-07-21 EE EEP200000054A patent/EE04046B1/xx not_active IP Right Cessation
2000
- 2000-01-05 BG BG104057A patent/BG65044B1/bg unknown
- 2000-01-21 NO NO20000310A patent/NO20000310D0/no not_active Application Discontinuation
- 2000-01-24 IS IS5359A patent/IS5359A/is unknown

Also Published As

Publication number	Publication date
US7067154B1 (en)	2006-06-27
PL338237A1 (en)	2000-10-09
ITFI970184A1 (it)	1999-01-30
HUP0100539A2 (hu)	2001-08-28
CZ2000199A3 (cs)	2000-05-17
EP0999843B1 (fr)	2004-07-21
ES2223135T3 (es)	2005-02-16
IL134268A0 (en)	2001-04-30
CZ297670B6 (cs)	2007-02-28
KR20010022319A (ko)	2001-03-15
PL189295B1 (pl)	2005-07-29
DE69825164D1 (de)	2004-08-26
HK1027751A1 (en)	2001-01-23
SI0999843T1 (en)	2005-02-28
CA2299420A1 (fr)	1999-02-11
EA200000181A1 (ru)	2000-10-30
PT999843E (pt)	2004-11-30
EE04046B1 (et)	2003-06-16
RS49703B (sr)	2007-12-31
SK802000A3 (en)	2000-07-11
ATE271387T1 (de)	2004-08-15
CA2299420C (fr)	2009-04-21
EA002492B1 (ru)	2002-06-27
EP0999843A1 (fr)	2000-05-17
JP2001511453A (ja)	2001-08-14
AU8978198A (en)	1999-02-22
NO20000310L (no)	2000-01-21
HU226112B1 (en)	2008-04-28
BR9810832A (pt)	2000-07-25
NO20000310D0 (no)	2000-01-21
YU3700A (sh)	2002-11-15
BR9810832B1 (pt)	2010-11-16
BG65044B1 (bg)	2007-01-31
KR100573421B1 (ko)	2006-04-26
SK284873B6 (sk)	2006-01-05
TR200000261T2 (tr)	2000-09-21
IS5359A (is)	2000-01-24
BG104057A (en)	2000-07-31
WO1999006051A1 (fr)	1999-02-11
JP4497496B2 (ja)	2010-07-07
EE200000054A (et)	2000-10-16
ID23504A (id)	2000-04-27

Publication	Publication Date	Title
UA61968C2 (en)	2003-12-15	Pharmaceutical compositions containing vitamin d and calcium, their manufacture and therapeutic use
CA2072513C (fr)	2002-03-26	Pastille ou comprime a croquer
ES2439741T3 (es)	2014-01-24	Composición que comprende componentes de gastrolitos de crustáceos, carbonato cálcico y su utilización
UA73727C2 (uk)	2005-09-15	Спосіб приготування кальцієвої композиції для перорального введення у формі таблеток
JPH05500052A (ja)	1993-01-14	胃酸を結合する薬学的製剤
KR101303325B1 (ko)	2013-09-03	오셀타미버 포스페이트 과립 및 그의 제조방법
JP3135273B2 (ja)	2001-02-13	保存安定性硫酸グルコースアミン経口薬剤とその製造方法
EP1651191B1 (fr)	2008-11-12	Compositions pharmaceutiques effervescentes contenant de la vitamine d, du calcium et du phosphate et leur utilisation therapeutique
CA2891362A1 (fr)	2014-05-22	Comprime effervescent
RU2130310C1 (ru)	1999-05-20	Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для внутреннего применения
JPH09502709A (ja)	1997-03-18	エストロン誘導体及びカルシウム塩含有の経口、水溶性製薬組成物
CN114306383A (zh)	2022-04-12	改善磷酸氢钙溶解性的促生长药物组合物及其制备工艺
JP2002509539A (ja)	2002-03-26	制酸剤とパパインの組合せ物
US2994639A (en)	1961-08-01	Antibiotic composition
JPS59144741A (ja)	1984-08-18	ホパンテン酸カルシウム組成物
CN102626420A (zh)	2012-08-08	一种含有锶、钙和维生素d的混合制剂
CN111511222A (zh)	2020-08-07	用于钙补充的组合物
HK1027751B (en)	2005-04-01	Pharmaceutical compositions containing vitamin d and calcium, their preparation and therapeutic use
MXPA00000684A (en)	2001-12-04	Pharmaceutical compositions containing vitamin d and calcium, their preparation and therapeutic use
CN1265595A (zh)	2000-09-06	含维生素d和钙的药物组合物,其制备方法和治疗应用
JPH04295425A (ja)	1992-10-20	ビタミンｃ含有ハード顆粒の製造方法
JPH03223228A (ja)	1991-10-02	医薬組成物
JPH10291933A (ja)	1998-11-04	カルシウム補給剤