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UA49089C2 - Похідні вуглеводів та фармацевтична композиція на їх основі - Google Patents

Похідні вуглеводів та фармацевтична композиція на їх основі

Info

Publication number
UA49089C2
UA49089C2 UA2000052804A UA00052804A UA49089C2 UA 49089 C2 UA49089 C2 UA 49089C2 UA 2000052804 A UA2000052804 A UA 2000052804A UA 00052804 A UA00052804 A UA 00052804A UA 49089 C2 UA49089 C2 UA 49089C2
Authority
UA
Ukraine
Prior art keywords
pharmaceutical composition
alkoxy
carbohydrate derivatives
oso3
treating
Prior art date
Application number
UA2000052804A
Other languages
English (en)
Russian (ru)
Inventor
Букель Констант Адріан Антон Ван
Моріс Петіту
Філіп Дюшоссуа
Корнелія Марія Дреф-Тромп
Йоханнес Е'бертус Марія Бастен
Original Assignee
Акзо Нобель Н.В.
Санофі-Сентелябо
Санофи-Сентелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Акзо Нобель Н.В., Санофі-Сентелябо, Санофи-Сентелябо filed Critical Акзо Нобель Н.В.
Publication of UA49089C2 publication Critical patent/UA49089C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Згідно з винаходом запропоновано похідне вуглеводу формули (І) , де R1 - (С1-С4)алкоксил, R2, R3 та R4, незалежно - (С1-С4)алкоксил чи ОSО3¯, загальне число сульфатних груп 4, 5 чи 6, зігнуті лінії являють собою зв'язки, що розташовані вище чи нижче площини шестичленного кільця, до якого вони приєднані, або його фармацевтично прийнятну сіль. Сполука, згідно з винаходом, має антитромботичні властивості і може бути корисною при лікуванні чи попередженні тромбозу та інгібуванні проліферації клітин гладких м'язів.
UA2000052804A 1997-11-19 1998-11-16 Похідні вуглеводів та фармацевтична композиція на їх основі UA49089C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203613 1997-11-19
PCT/EP1998/007518 WO1999025720A1 (en) 1997-11-19 1998-11-16 Carbohydrate derivatives

Publications (1)

Publication Number Publication Date
UA49089C2 true UA49089C2 (uk) 2002-09-16

Family

ID=8228942

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000052804A UA49089C2 (uk) 1997-11-19 1998-11-16 Похідні вуглеводів та фармацевтична композиція на їх основі

Country Status (33)

Country Link
US (1) US6174863B1 (uk)
EP (1) EP1032579B1 (uk)
JP (1) JP4364959B2 (uk)
KR (1) KR100518497B1 (uk)
CN (1) CN1177855C (uk)
AR (1) AR017640A1 (uk)
AT (1) ATE239030T1 (uk)
AU (1) AU746959B2 (uk)
BR (1) BRPI9804699B1 (uk)
CA (1) CA2253113C (uk)
CO (1) CO4990974A1 (uk)
CZ (1) CZ293639B6 (uk)
DE (1) DE69814140T2 (uk)
DK (1) DK1032579T3 (uk)
EE (1) EE04348B1 (uk)
ES (1) ES2198081T3 (uk)
HU (1) HU226685B1 (uk)
ID (1) ID21287A (uk)
IL (1) IL126893A (uk)
IS (1) IS2527B (uk)
NO (1) NO310723B1 (uk)
NZ (1) NZ332834A (uk)
PE (1) PE134799A1 (uk)
PL (1) PL188229B1 (uk)
PT (1) PT1032579E (uk)
RU (1) RU2210573C2 (uk)
SG (1) SG72889A1 (uk)
SK (1) SK284134B6 (uk)
TR (1) TR199802372A2 (uk)
TW (1) TW448180B (uk)
UA (1) UA49089C2 (uk)
WO (1) WO1999025720A1 (uk)
ZA (1) ZA9810559B (uk)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
WO2002058633A2 (en) * 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
WO2005085264A1 (en) * 2004-03-04 2005-09-15 Progen Industries Limited Sulfated oligosaccharide derivatives
RU2538973C2 (ru) 2008-05-30 2015-01-10 Момента Фармасьютикалз, Инк. Структуры сахаридов и способы получения и применения таких структур
US20110150976A1 (en) * 2008-09-10 2011-06-23 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
ES2939741T3 (es) 2009-07-31 2023-04-26 Reliable Biopharmaceutical Llc Proceso para preparar fondaparinux sódico y productos intermedios útiles en la síntesis del mismo
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
JP6051211B2 (ja) * 2011-06-17 2016-12-27 カルボミメティクス 半減期が短く活性が高い合成五糖類
EP2578594A1 (en) 2011-10-04 2013-04-10 Sanofi Process of preparation of L-iduronic acid comprising a decarboxylation/intramolecular cyclisation tandem reaction
US9873712B2 (en) 2014-10-03 2018-01-23 Amphastar Pharmaceuticals, Inc. Method of purifying idraparinux sodium
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
WO2021043631A1 (en) 2019-09-02 2021-03-11 Hepoligo Solutions Aps Intermediates useful for preparing iduronic acid containing di- and polysaccharides
WO2021211441A1 (en) * 2020-04-13 2021-10-21 The Board Of Regents Of The University Of Oklahoma Modified sugar polymers with low anticoagulant activity and therapeutic activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
DE69100275T2 (de) * 1990-04-23 1993-12-02 Akzo Nv Eine Trisaccharideinheit enthaltende Kohlenhydratderivate.
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
DK1032579T3 (da) 2003-08-25
RU2210573C2 (ru) 2003-08-20
PT1032579E (pt) 2003-08-29
WO1999025720A1 (en) 1999-05-27
IL126893A0 (en) 1999-09-22
HUP9802663A2 (hu) 1999-06-28
ATE239030T1 (de) 2003-05-15
AR017640A1 (es) 2001-09-12
CZ293639B6 (cs) 2004-06-16
EE04348B1 (et) 2004-08-16
EE200000301A (et) 2001-12-17
BR9804699A (pt) 2000-12-26
AU9324298A (en) 1999-06-17
CA2253113C (en) 2008-06-17
TW448180B (en) 2001-08-01
PL188229B1 (pl) 2004-12-31
DE69814140D1 (de) 2003-06-05
KR100518497B1 (ko) 2005-12-16
CN1222524A (zh) 1999-07-14
CO4990974A1 (es) 2000-12-26
ES2198081T3 (es) 2004-01-16
HUP9802663A3 (en) 2000-04-28
IS2527B (is) 2009-07-15
IL126893A (en) 2003-05-29
HU9802663D0 (en) 1999-01-28
IS5485A (is) 2000-05-09
KR19990045312A (ko) 1999-06-25
CN1177855C (zh) 2004-12-01
CA2253113A1 (en) 1999-05-19
US6174863B1 (en) 2001-01-16
PE134799A1 (es) 2000-01-07
ID21287A (id) 1999-05-20
EP1032579A1 (en) 2000-09-06
JP4364959B2 (ja) 2009-11-18
NO310723B1 (no) 2001-08-20
HU226685B1 (en) 2009-06-29
CZ376198A3 (cs) 1999-06-16
DE69814140T2 (de) 2004-04-08
SG72889A1 (en) 2000-05-23
PL329789A1 (en) 1999-05-24
AU746959B2 (en) 2002-05-09
NZ332834A (en) 2000-01-28
ZA9810559B (en) 1999-05-15
HK1028406A1 (en) 2001-02-16
NO985365D0 (no) 1998-11-18
BRPI9804699B1 (pt) 2016-07-12
NO985365L (no) 1999-05-20
SK284134B6 (sk) 2004-09-08
JPH11217394A (ja) 1999-08-10
SK7362000A3 (en) 2000-10-09
EP1032579B1 (en) 2003-05-02
TR199802372A2 (xx) 1999-06-21

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