UA128936U - METHOD OF FORECASTING OSTEOARTHrosis DEVELOPMENT - Google Patents

Abstract

A method for predicting the development of osteoarthritis includes clinical examination, radiography. Serum polymorphism of the eNOS T786C gene and thrombomodulin, osteocalcin, homocysteine, IL-6, with 786-SS homozygous carrier and thrombomodulin levels> 5 ng / ml, osteocalcin <21 ng / ml, osteocalcin <21 ng / ml, determine the serum -6> 10 ng / l predict the development of osteoarthritis.

Description

A useful model belongs to medicine, in particular to orthopedics and rheumatology, and can be used in the diagnosis of the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, examination of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (A.N. Okorokov. Diagnostics of diseases of internal organs. M., 2001. - vol. 2. - pp. 186-196).

The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, the polymorphism of the nitric oxide synthase gene (eMO5 1786C), the content of thrombomodulin, osteocalcin, homocysteine, interleukin b (IL-6) is determined in the patient's blood serum, and in the case of homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, osteocalcin "21 ng/ml, homocysteine 220 μmol/l, IL-6 210 ng/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, X-rays are taken, the polymorphism of the eMO5 1786C gene is determined, the content of thrombomodulin, osteocalcin, homocysteine, 1L-6 is determined by the immunoenzymatic method. With homozygous carrier 786-SS and levels of thrombomodulin "5 ng/ml, osteocalcin "21 ng/ml, homocysteine 220 μmol/l, IL-b6 "10 ng/l predict the development of osteoarthritis.

A specific example of using the method.

Patient V., 57 years old, was hospitalized in the clinic due to pain syndrome of the left hip joint. X-rays were examined and carried out. No signs of osteoarthritis were found. The eMO5 1786C gene polymorphism and the content of thrombomodulin, osteocalcin, homocysteine, and IL-6 were determined in the serum. Established homozygous carrier 786-

SS, levels of thrombomodulin - 12 ng/ml, osteocalcin - 15 ng/ml, homocysteine - 30 μmol/l, IL-6 - 14 ng/l. The development of osteoarthritis was diagnosed. After 13 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing development

From osteoarthritis in the early stages.

Claims (1)

USEFUL MODEL FORMULA The method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the eMOo5 gene polymorphism T7860 and the content of thrombomodulin, osteocalcin, homocysteine, IL-b6 are determined in the blood serum, with homozygous carrier 786-SS and thrombomodulin levels of 25 ng/ml , osteocalcin "21 ng/ml, homocysteine 220 μmol/l, IL-6 510 ng/l predict the development of osteoarthritis.