UA11926U - Method for immune correction - Google Patents

Abstract

The method for immune correction comprises the use of the freshly frozen blood plasma and Cycloferon. In addition, hydrocortisone and prednisolon are used as immunosuppressive agents for 6 days.

Description

Description of the invention

The useful model refers to medicine, namely to immunology and can be used in the treatment of 2 diseases, the basis of which is the dysfunction of the immune system and non-specific resistance.

The method of immunocorrective therapy, which includes the use of immunomodulators - fresh frozen plasma and cycloferon | Method of immunomodulation, was chosen as the closest analogue. Kilessa V.V., Prytulo L.F., Biloglazov V.O.

IPK Ab6I1K 35/00, Mb1508A. Application No. 2003021411 dated February 18, 2003. Published on October 17, 2003. Bul. Mo111.

Signs that coincide with the main signs of the proposed method are: the use of preparation 70 fresh frozen plasma and cycloferon.

The reasons preventing the achievement of the expected technical result (increasing the effectiveness of the treatment of diseases based on immune dysfunction and non-specific resistance): does not provide inhibition of the hyperfunction of the neutrophil granulocyte system, which does not prevent the development of purulent complications. 12 The basis of a useful model is the task of improving the method of immunocorrective therapy through the additional use of glucocorticosteroids by ensuring, on the one hand, an increase in the functional activity of the immune system, and on the other hand, inhibition of the function of the main component of the system of non-specific resistance - the neutrophil granulocyte system.

The task is solved by the fact that in the method of immunocorrective therapy, which includes the use of fresh-frozen plasma and cycloferon, according to a useful model, the immunosuppressant hydrocortisone 100 ml IV drip and prednisone 60 mg IV for 6 days are additionally used.

The use of fresh-frozen plasma and cycloferon provides an increase in T-cell and humoral immunity, while the inclusion of an immunosuppressant - a glucocorticosteroid in the immunotherapy complex leads to a decrease in the functional activity of neutrophil granulocytes, which prevents local and widespread hyperenzymemia, which is responsible for the development of purulent-destructive, septic phenomena. collapse and shock. in

The proposed method is performed as follows.

A patient with immune system dysfunction and non-specific resistance is simultaneously prescribed immunomodulatory and immunosuppressive therapy.

As an anti-inflammatory agent, the immunosuppressant hydrocortisone 100 ml IV drip and prednisolone EE, 0 mg IV for 6 days are used. with

7 people were treated with the proposed method with a positive effect.

We cite the following cases as examples. Me.

Example 1 "--

Patient K., 51 years old, was being treated in the therapeutic department. Diagnosis: out-of-hospital 3rd left-sided pneumonia in the lower lobe and lingual segments of the upper lobe. II! category. --

When the patient is admitted to the hospital, the condition is severe. He complains of shortness of breath at rest, which worsens when walking, cough with purulent sputum, chest pain, lack of appetite, weight loss.

He became acutely ill 2 weeks before admission to the hospital. Outpatient treatment, which included the use of cefazolin 2 g per day, anti-inflammatory and expectorants, was not effective. WITH

During the clinical and radiological examination, a diagnosis of out-of-hospital left-sided pneumonia with localization in the uvular segments of the upper lobe and lower lobe of the left lung was made. :z» In the blood analysis.: Hv-15Og/l, er-4.58X102/l, c.p.-0.98, l-8.5x109/l, rod-nuclear - 2695, segment-nuclear - 61905, eoz-1965 , lymphocytes-79o, monocytes-5960, ESR-15 mm/h.

The patient was prescribed treatment according to the proposed method: metrogil, ceftriaxone, amikacin, - 395 lazolvan, abactal. As an anti-inflammatory agent - immunosuppressant hydrocortisone 100 ml IV drip and prednisone 60 mg IV for 6 days. - As a result of the treatment, the condition improved - shortness of breath, cough with purulent sputum discharge decreased, body temperature decreased. At the same time, attention was drawn to lymphopenia, which was preserved in the blood test. ko 50 On the 7th day of the patient's stay in the hospital, the condition worsened: the body temperature rose to 38.6 2C,

A sharp weakness was observed. The treatment was carried out in the previous "pharmacological" mode with the use of antipyretic agents, but no tendency to lower body temperature was observed.

The patient was prescribed immunomodulatory therapy, which included intravenous drip administration of 200 ml of fresh frozen plasma and intravenous drip administration of cycloferon solution of 10 ml, according to the scheme on the 1st and 2nd day, then every other day, in the total number of 5 administrations of the drug. c 2 days after the start of immunostimulating therapy, the condition improved, the temperature dropped to subfebrile numbers. After a few days, the condition returned to normal. The following was established during the dynamic study of the blood analysis. In the blood analysis: the content of leukocytes b, 8x109/l, rod-nuclear - 595, segmentonuclear - 7390, lymphocytes - 1595, monocytes - 790. ESR - 17 mm/h. In the blood test from 14.03. - leukocytes - 6, x109/l, rod-nuclear - 596, segmentonuclear - 5595, eos - 1906, lymphocytes - 29965, monocytes - 1095. In the blood analysis from 03.21 - leukocytes - 3.9x1 Ol, rod-nuclear - 695, segmentonuclear - 42905, eosis - 695, B-1905, lymphocytes - 3890, monocytes - 795. ESR - 20 mm/h.

The clinical and radiological condition of the patient improved progressively. Discharge from the department without any 65 clinical and radiological manifestations of pneumonic infiltration.

Example 2

Patient Kh., 33 years old, was admitted to the therapeutic department. Diagnosis: Out-of-hospital left-sided polysegmental pneumonia, which was complicated by pleural abscess and empyema. Post-necrotic cirrhosis of the liver caused by hepatitis B and C viruses, portal hypertension. HIV infection.

When the patient is admitted to the hospital, the patient's condition is serious. Whispered speech, complaints of shortness of breath, chills, cough with "rust-colored" sputum, chest pain, bloating and abdominal distension. On objective examination - icteric skin and sclera. ChDD - 24-28 in G. Increase in the size of the abdomen, expansion of the subcutaneous veins of the abdominal wall. In the lungs, during auscultation, breathing is hard, dry, scattered wheezes on the right, breathing is weakened on the left, with a hard tone, wet fine-bubbled wheezing and crepitation. During the x-ray examination of the respiratory organs, which was performed upon admission, polysegmental pneumonia was detected in the left lung.

In the blood analysis: Nv - 146 g/l, er - 4.62x1012/l, c.p. - 0.9, leukocytes -17.9x109/l, young - 195, rod-nuclear - 2690, segmentonuclear - 6695, lymphocytes -495, monocytes - 395. Toxogenic granularity of cytoplasm of neutrophils - 7095, ESR - mm/h.

Upon admission, the patient was prescribed standard antibacterial treatment - ceftriaxone, metronidazole, amikacin, plasma substitute - reosorbilact, expectorants. Despite the treatment, the condition continued to be severe for 7 days. Hyperthermia persisted. X-ray examination revealed the progression of pneumonic infiltration zones in the left lung with cavity formations in

Zv.

Intravenous infusions of prednisone solution 60 mg per day were added to the patient's treatment. The patient was transfused with fresh-frozen plasma of the same group in the amount of 200 ml. 4 days after the treatment, the body temperature normalized, the condition significantly improved. Dynamic observation of changes in blood analysis revealed the following.

Blood analysis from April 25 - Nv - 129g/l, er-4.16x102/l, c.p.-0.9; leukocytes -26.4x109/l, p-1595, p-5495, l-895, m-23905. Pl. cells 2:100, ESR - 12 mm/h. Blood analysis from 04.05. (after using immunocorrective C therapy) - Hb -111.8g/l, er-3.78x1012/l, c.p.-0.88, leukocytes - 9.8x107, p-796, c-6795, e-096 , l-17965, m-7905, sq. cells - 2, ESR - 20 mm/h.

The presence of antibodies to HIV was confirmed when conducting research with 2-X test systems for ELISA. In the subsequent X-ray study, a progressive reduction of pneumonic infiltration (se) on the left side, organization of a paracostal pleural effusion was observed. After a puncture of the paracostal pleural effusion, its purulent nature was revealed. Later, he was transferred to a specialized department. Gee)

Claims (1)

"- Formula of the invention "- A method of immunocorrective therapy that includes the use of a preparation of fresh frozen plasma and cycloferon, which is distinguished by the fact that the immunosuppressant hydrocortisone is additionally used 100 ml IV "dropwise and prednisolone 60 mg IV for 6 days. - . and? - - se) ime) 4) 60 b5