UA117470C2 - Заміщені ксантини та способи їх застосування - Google Patents
Заміщені ксантини та способи їх застосуванняInfo
- Publication number
- UA117470C2 UA117470C2 UAA201507774A UAA201507774A UA117470C2 UA 117470 C2 UA117470 C2 UA 117470C2 UA A201507774 A UAA201507774 A UA A201507774A UA A201507774 A UAA201507774 A UA A201507774A UA 117470 C2 UA117470 C2 UA 117470C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- substituted xanthines
- xanthines
- substituted
- trpc5
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 title 1
- 102000003621 TRPC5 Human genes 0.000 abstract 2
- 101150042815 TRPC5 gene Proteins 0.000 abstract 2
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Medicinal Preparation (AREA)
Abstract
Описаними є сполуки, композиції та способи інгібування TRPC5 іонного каналу та розладів, пов'язаних з TRPC5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789724P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/027920 WO2014143799A2 (en) | 2013-03-15 | 2014-03-14 | Substituted xanthines and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA117470C2 true UA117470C2 (uk) | 2018-08-10 |
Family
ID=50680155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201507774A UA117470C2 (uk) | 2013-03-15 | 2014-03-14 | Заміщені ксантини та способи їх застосування |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US9359359B2 (uk) |
| EP (1) | EP2970303B3 (uk) |
| JP (1) | JP6360149B2 (uk) |
| KR (1) | KR102227629B1 (uk) |
| CN (2) | CN107082782B (uk) |
| AU (1) | AU2014228206C1 (uk) |
| CA (1) | CA2899646C (uk) |
| CL (1) | CL2015002738A1 (uk) |
| CY (1) | CY1119042T1 (uk) |
| DK (1) | DK2970303T6 (uk) |
| EA (1) | EA028815B1 (uk) |
| ES (1) | ES2636835T7 (uk) |
| HR (1) | HRP20170840T4 (uk) |
| HU (1) | HUE033528T4 (uk) |
| IL (1) | IL240216B (uk) |
| LT (1) | LT2970303T (uk) |
| MX (1) | MX370372B (uk) |
| MY (1) | MY189912A (uk) |
| NZ (1) | NZ711718A (uk) |
| PE (1) | PE20151779A1 (uk) |
| PH (1) | PH12015502141B1 (uk) |
| PL (1) | PL2970303T6 (uk) |
| PT (1) | PT2970303T (uk) |
| RS (1) | RS56066B2 (uk) |
| SG (1) | SG11201506479TA (uk) |
| SI (1) | SI2970303T1 (uk) |
| TW (1) | TWI609867B (uk) |
| UA (1) | UA117470C2 (uk) |
| UY (1) | UY35488A (uk) |
| WO (1) | WO2014143799A2 (uk) |
| ZA (1) | ZA201505414B (uk) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| EP2970303B3 (en) | 2013-03-15 | 2018-08-01 | Hydra Biosciences, Inc. | Substituted xanthines and methods of use thereof |
| EP3180342B1 (en) * | 2014-08-11 | 2019-06-26 | Hydra Biosciences, Inc. | Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives |
| GB2553684B (en) | 2015-03-27 | 2020-06-03 | Latvian Inst Organic Synthesis | Ethynylxanthines, preparation and use for cancer treatment |
| GB2553685B (en) | 2015-03-27 | 2020-06-10 | Latvian Inst Organic Synthesis | Novel ethynylxanthines for use as inhibitors of matrix metalloproteinases and angiogenesis |
| GB2553686B (en) | 2015-03-27 | 2020-06-03 | Latvian Inst Organic Synthesis | Ethynylxanthines, preparation and use as calcium ion channel modulators |
| MX380672B (es) * | 2015-04-08 | 2025-03-12 | Lewis And Clark Pharmaceuticals Inc | Carbamatos de alquinilo sustituidos por xantina/carbamatos inversos como antagonistas de a2b |
| CN107118586A (zh) * | 2016-02-24 | 2017-09-01 | 中国科学技术大学 | 含氮杂环基取代的烯类化合物的用途 |
| GB201702160D0 (en) * | 2017-02-09 | 2017-03-29 | Univ Leeds Innovations Ltd | Inhibitors for use in therapy |
| WO2018157800A1 (en) * | 2017-02-28 | 2018-09-07 | National Institute Of Biological Sciences, Beijing | Mlkl inhibitors |
| US11666577B2 (en) * | 2017-02-28 | 2023-06-06 | National Institute Of Biological Sciences, Beijing | MLKL inhibitors |
| CN110997675B (zh) * | 2017-07-11 | 2022-06-07 | 勃林格殷格翰国际公司 | 新的取代的黄嘌呤衍生物 |
| CA3093084A1 (en) * | 2018-03-05 | 2019-09-12 | Goldfinch Bio, Inc. | Imidazodiazepinediones and methods of use thereof |
| JP7408662B2 (ja) * | 2018-12-12 | 2024-01-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換キサンタン誘導体 |
| JP7502299B2 (ja) * | 2018-12-12 | 2024-06-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換キサンチン誘導体 |
| CN112979651B (zh) * | 2021-04-09 | 2022-02-01 | 南京纽邦生物科技有限公司 | 一种副黄嘌呤的制备方法 |
| CN113354646B (zh) * | 2021-07-06 | 2022-11-15 | 南开大学 | 8-芳氧基烷氧基取代黄嘌呤衍生物及其制备方法和应用 |
| CN115636831B (zh) * | 2022-10-27 | 2024-11-08 | 中国药科大学 | 稠合嘧啶二酮类化合物、其用途以及药物组合物 |
| CN120379994A (zh) | 2022-12-20 | 2025-07-25 | 勃林格殷格翰国际有限公司 | 用于制备7-(4-氯苄基)-1-(3-羟基丙基)-3-甲基-8-(3-(三氟甲氧基)-苯氧基)-3,7-二氢-1h-嘌呤-2,6-二酮的方法 |
| CN118373832B (zh) * | 2023-01-20 | 2025-01-28 | 深圳晶蛋生物医药科技有限公司 | 大环类化合物、其药物组合物及其应用 |
| WO2024165540A1 (en) | 2023-02-06 | 2024-08-15 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising 7-(4-chlorobenzyl)-1-(3-hydroxypropyl)-3-methyl-8-(3-(trifluoromethoxy)-phenoxy)-3,7-dihydro-1h-purine-2,6-dione |
| KR20250141831A (ko) | 2023-02-08 | 2025-09-29 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 잔틴계 화합물 및 이의 용도 |
| WO2025250920A1 (en) | 2024-05-31 | 2025-12-04 | Gfb (Abc), Llc | Pyridazinone phosphate compounds, pharmaceutical compositions, and medical uses thereof |
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| DE4304650A1 (de) * | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6878715B1 (en) * | 1994-02-18 | 2005-04-12 | Cell Therapeutics, Inc. | Therapeutic compounds for inhibiting interleukin-12 signals and method for using same |
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| JPH10318487A (ja) | 1997-05-16 | 1998-12-04 | Mitsubishi Gas Chem Co Inc | 真空断熱材用ゲッタ |
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| US8143254B2 (en) | 2005-02-18 | 2012-03-27 | Cornell Research Foundation, Inc. | Methods for modulating ion channels |
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| ATE459620T1 (de) * | 2005-09-06 | 2010-03-15 | Glaxosmithkline Llc | Benzimidazolthiophenverbindungen als plk- modulatoren |
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| WO2007084728A2 (en) | 2006-01-19 | 2007-07-26 | Abbott Laboratories | 2-imino-benzimidazoles |
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| WO2012050641A2 (en) | 2010-06-08 | 2012-04-19 | Hydra Biosciences, Inc | Use of trpa1 antagonists to prevent or treat infections caused by biological-warfare agents |
| JP2013023102A (ja) * | 2011-07-22 | 2013-02-04 | Panasonic Corp | 列車情報提供システム |
| BR112014002960A2 (pt) * | 2011-08-09 | 2017-02-21 | Cubist Pharm Inc | inibição de canal de íons potencial receptor transiente trpa1 |
| CN103121970B (zh) | 2012-12-04 | 2015-04-29 | 中国科学院昆明植物研究所 | 苯并咪唑及其衍生物，其药物组合物及其在制备抗抑郁药物中的应用 |
| EP2970303B3 (en) | 2013-03-15 | 2018-08-01 | Hydra Biosciences, Inc. | Substituted xanthines and methods of use thereof |
-
2014
- 2014-03-14 EP EP14722452.1A patent/EP2970303B3/en active Active
- 2014-03-14 PT PT147224521T patent/PT2970303T/pt unknown
- 2014-03-14 PL PL14722452T patent/PL2970303T6/pl unknown
- 2014-03-14 RS RS20170566A patent/RS56066B2/sr unknown
- 2014-03-14 WO PCT/US2014/027920 patent/WO2014143799A2/en not_active Ceased
- 2014-03-14 CN CN201710063554.XA patent/CN107082782B/zh active Active
- 2014-03-14 TW TW103109651A patent/TWI609867B/zh active
- 2014-03-14 HR HRP20170840TT patent/HRP20170840T4/hr unknown
- 2014-03-14 CN CN201480023267.0A patent/CN105143229B/zh active Active
- 2014-03-14 AU AU2014228206A patent/AU2014228206C1/en active Active
- 2014-03-14 JP JP2016502662A patent/JP6360149B2/ja active Active
- 2014-03-14 EA EA201591615A patent/EA028815B1/ru not_active IP Right Cessation
- 2014-03-14 LT LTEP14722452.1T patent/LT2970303T/lt unknown
- 2014-03-14 DK DK14722452.1T patent/DK2970303T6/en active
- 2014-03-14 UA UAA201507774A patent/UA117470C2/uk unknown
- 2014-03-14 NZ NZ711718A patent/NZ711718A/en unknown
- 2014-03-14 CA CA2899646A patent/CA2899646C/en active Active
- 2014-03-14 SG SG11201506479TA patent/SG11201506479TA/en unknown
- 2014-03-14 HU HUE14722452A patent/HUE033528T4/en unknown
- 2014-03-14 KR KR1020157029667A patent/KR102227629B1/ko active Active
- 2014-03-14 US US14/210,781 patent/US9359359B2/en active Active
- 2014-03-14 MY MYPI2015702631A patent/MY189912A/en unknown
- 2014-03-14 PE PE2015001829A patent/PE20151779A1/es active IP Right Grant
- 2014-03-14 MX MX2015011617A patent/MX370372B/es active IP Right Grant
- 2014-03-14 SI SI201430241T patent/SI2970303T1/sl unknown
- 2014-03-14 ES ES14722452.1T patent/ES2636835T7/es active Active
- 2014-03-17 UY UY0001035488A patent/UY35488A/es active IP Right Grant
-
2015
- 2015-07-28 ZA ZA2015/05414A patent/ZA201505414B/en unknown
- 2015-07-29 IL IL240216A patent/IL240216B/en active IP Right Grant
- 2015-09-15 PH PH12015502141A patent/PH12015502141B1/en unknown
- 2015-09-15 CL CL2015002738A patent/CL2015002738A1/es unknown
-
2016
- 2016-04-25 US US15/137,327 patent/US20160237089A1/en not_active Abandoned
-
2017
- 2017-06-14 US US15/622,838 patent/US9969736B2/en active Active
- 2017-06-20 CY CY20171100647T patent/CY1119042T1/el unknown
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2018
- 2018-05-02 US US15/968,941 patent/US10399982B2/en active Active
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2019
- 2019-04-29 US US16/397,697 patent/US11208409B2/en active Active
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2021
- 2021-11-10 US US17/523,838 patent/US11958854B2/en active Active
-
2024
- 2024-02-21 US US18/583,293 patent/US20250034143A1/en not_active Abandoned
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