UA101645C2 - Normal;heading 1;heading 2;heading 3; PYRIDINONES AND PYRIDAZINONES - Google Patents
Normal;heading 1;heading 2;heading 3; PYRIDINONES AND PYRIDAZINONESInfo
- Publication number
- UA101645C2 UA101645C2 UAA201010581A UAA201010581A UA101645C2 UA 101645 C2 UA101645 C2 UA 101645C2 UA A201010581 A UAA201010581 A UA A201010581A UA A201010581 A UAA201010581 A UA A201010581A UA 101645 C2 UA101645 C2 UA 101645C2
- Authority
- UA
- Ukraine
- Prior art keywords
- heading
- btk
- compounds
- phenyl
- iii
- Prior art date
Links
- 150000005299 pyridinones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- IJUIPRDMWWBTTQ-UHFFFAOYSA-N 3-phenyl-1h-pyridazin-6-one Chemical class N1C(=O)C=CC(C=2C=CC=CC=2)=N1 IJUIPRDMWWBTTQ-UHFFFAOYSA-N 0.000 abstract 1
- RWFAQYWIBBVEBY-UHFFFAOYSA-N 5-phenyl-1h-pyridin-2-one Chemical compound N1C(=O)C=CC(C=2C=CC=CC=2)=C1 RWFAQYWIBBVEBY-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-III: wherein, variables R, X, Y, Y, Y, Y, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and autoimmune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2620408P | 2008-02-05 | 2008-02-05 | |
| PCT/EP2009/050875 WO2009098144A1 (en) | 2008-02-05 | 2009-01-27 | Novel pyridinones and pyridazinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA101645C2 true UA101645C2 (en) | 2013-04-25 |
Family
ID=51950339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201010581A UA101645C2 (en) | 2008-02-05 | 2009-01-27 | Normal;heading 1;heading 2;heading 3; PYRIDINONES AND PYRIDAZINONES |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA101645C2 (en) |
-
2009
- 2009-01-27 UA UAA201010581A patent/UA101645C2/en unknown
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