UA100974C2 - Substituted diazepan compounds as orexin receptor antagonists - Google Patents
Substituted diazepan compounds as orexin receptor antagonistsInfo
- Publication number
- UA100974C2 UA100974C2 UAA200906864A UAA200906864A UA100974C2 UA 100974 C2 UA100974 C2 UA 100974C2 UA A200906864 A UAA200906864 A UA A200906864A UA A200906864 A UAA200906864 A UA A200906864A UA 100974 C2 UA100974 C2 UA 100974C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- receptor antagonists
- orexin receptor
- substituted diazepan
- substituted
- Prior art date
Links
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical class C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 title abstract 2
- 229940123730 Orexin receptor antagonist Drugs 0.000 title 1
- 108050000742 Orexin Receptor Proteins 0.000 abstract 3
- 102000008834 Orexin receptor Human genes 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87239306P | 2006-12-01 | 2006-12-01 | |
| PCT/US2007/024690 WO2008069997A1 (en) | 2006-12-01 | 2007-11-30 | Substituted diazepan compounds as orexin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA100974C2 true UA100974C2 (en) | 2013-02-25 |
Family
ID=41522310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200906864A UA100974C2 (en) | 2006-12-01 | 2007-11-30 | Substituted diazepan compounds as orexin receptor antagonists |
| UAA201015209A UA106873C2 (en) | 2006-12-01 | 2007-11-30 | COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201015209A UA106873C2 (en) | 2006-12-01 | 2007-11-30 | COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN101627028B (en) |
| HN (1) | HN2009001067A (en) |
| UA (2) | UA100974C2 (en) |
| ZA (1) | ZA200903334B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015005891A (en) * | 2012-11-12 | 2015-12-09 | Reddys Lab Ltd Dr | Polymorphic forms of suvoroxant. |
| CN103012293A (en) * | 2012-12-13 | 2013-04-03 | 同济大学 | Synthetic method for anti-sleeplessness medicine MK-4305 intermediate |
| CN103923068B (en) * | 2014-02-13 | 2016-09-07 | 武汉珈瑜科技有限公司 | For compound preparing suvorexant and preparation method thereof |
| CN105377840B (en) * | 2014-05-28 | 2017-12-22 | 杭州普晒医药科技有限公司 | The salt and its crystal formation and amorphous article of a kind of diazepan compounds |
| WO2016020405A1 (en) * | 2014-08-04 | 2016-02-11 | Sandoz Ag | Novel routes of synthesis for the preparation of suvorexant |
| CN105461699B (en) * | 2014-09-25 | 2019-07-09 | 广东东阳光药业有限公司 | Substituted heterocyclic compound and its application method and purposes |
| CN104327061A (en) * | 2014-10-19 | 2015-02-04 | 湖南华腾制药有限公司 | Preparation method of bromobenzo[d]oxazole derivative |
| CN104649983B (en) * | 2014-12-23 | 2018-01-23 | 广东东阳光药业有限公司 | A kind of sour preparation method |
| CN106349228B (en) * | 2015-07-17 | 2019-07-09 | 广东东阳光药业有限公司 | Substituted quinazolinone compounds and preparation method and use thereof |
| CA3005918C (en) * | 2015-11-23 | 2023-10-17 | Sunshine Lake Pharma Co., Ltd. | Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof |
| CN106916149A (en) * | 2015-12-25 | 2017-07-04 | 上海奥博生物医药技术有限公司 | A kind of method for preparing Su Woleisheng |
| CN107021964A (en) * | 2016-02-01 | 2017-08-08 | 广东东阳光药业有限公司 | 7-naphthyridine derivatives and application thereof |
| CN105949203B (en) * | 2016-05-24 | 2018-07-13 | 广东东阳光药业有限公司 | Octahydro pyrrolo- [3,4-c] azole derivatives and its application method and purposes |
| CN106866632A (en) * | 2017-01-19 | 2017-06-20 | 成都美域高制药有限公司 | A kind of method for preparing Suvorexant intermediates and the like |
| CN109942563A (en) * | 2017-12-21 | 2019-06-28 | 上海医药工业研究院 | A kind of preparation method of Su Woleisheng midbody compound |
| AU2020286381C1 (en) * | 2019-06-04 | 2025-07-10 | Hager Biosciences, Llc | Imidazolo derivatives, compositions and methods as orexin antagonists |
| CN111943945B (en) * | 2020-09-03 | 2022-07-12 | 上海应用技术大学 | Suvorexant intermediate and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4966691A (en) * | 1972-10-30 | 1974-06-27 | ||
| AU3578595A (en) * | 1994-11-25 | 1996-06-19 | Nippon Chemiphar Co. Ltd. | Quinazoline derivative |
| AU2004269892B2 (en) * | 2003-09-09 | 2010-03-11 | F. Hoffmann-La Roche Ag | 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
-
2007
- 2007-11-30 UA UAA200906864A patent/UA100974C2/en unknown
- 2007-11-30 CN CN200780050811.0A patent/CN101627028B/en active Active
- 2007-11-30 UA UAA201015209A patent/UA106873C2/en unknown
-
2009
- 2009-05-14 ZA ZA200903334A patent/ZA200903334B/en unknown
- 2009-05-26 HN HN2009001067A patent/HN2009001067A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200903334B (en) | 2010-04-28 |
| UA106873C2 (en) | 2014-10-27 |
| HN2009001067A (en) | 2011-05-11 |
| CN101627028A (en) | 2010-01-13 |
| CN101627028B (en) | 2013-03-27 |
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