UA109420C2 - PHARMACEUTICAL COMPOSITION INCLUDING GLP-1 AGONIST, INSULIN AND METHIONINE - Google Patents
PHARMACEUTICAL COMPOSITION INCLUDING GLP-1 AGONIST, INSULIN AND METHIONINEInfo
- Publication number
- UA109420C2 UA109420C2 UAA201207165A UAA201207165A UA109420C2 UA 109420 C2 UA109420 C2 UA 109420C2 UA A201207165 A UAA201207165 A UA A201207165A UA A201207165 A UAA201207165 A UA A201207165A UA 109420 C2 UA109420 C2 UA 109420C2
- Authority
- UA
- Ukraine
- Prior art keywords
- agonist
- methionine
- insulin
- pharmaceutical composition
- composition including
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title abstract 2
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 229930182817 methionine Natural products 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 abstract 1
- 229930195722 L-methionine Natural products 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229960004452 methionine Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Винахід стосується рідкої композиції, що включає агоніст GLP-1 (desProексендин-4(1-39)-LyS-NH) і/або його фармакологічно прийнятну сіль, інсулін (Gly(A21)-Arg(B31)-Arg(B32)-iнcyлiн людини) і/або його фармакологічно прийнятну сіль і, необов'язково, щонайменше одну фармацевтично прийнятну допоміжну речовину, де дана композиція містить L-метіонін та має значення pH від 3,5 до 4,5.The invention relates to a liquid composition comprising the GLP-1 agonist (desProexendin-4 (1-39) -LyS-NH) and / or its pharmacologically acceptable salt, insulin (Gly (A21) -Arg (B31) -Arg (B32) - human incyline) and / or its pharmacologically acceptable salt and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition contains L-methionine and has a pH of from 3.5 to 4.5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009052831 | 2009-11-13 | ||
| PCT/EP2010/067250 WO2011058083A1 (en) | 2009-11-13 | 2010-11-11 | Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA109420C2 true UA109420C2 (en) | 2015-08-25 |
Family
ID=54772073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201207165A UA109420C2 (en) | 2009-11-13 | 2010-11-11 | PHARMACEUTICAL COMPOSITION INCLUDING GLP-1 AGONIST, INSULIN AND METHIONINE |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA109420C2 (en) |
-
2010
- 2010-11-11 UA UAA201207165A patent/UA109420C2/en unknown
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