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UA106619C2 - Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти - Google Patents

Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти

Info

Publication number
UA106619C2
UA106619C2 UAA201200649A UAA201200649A UA106619C2 UA 106619 C2 UA106619 C2 UA 106619C2 UA A201200649 A UAA201200649 A UA A201200649A UA A201200649 A UAA201200649 A UA A201200649A UA 106619 C2 UA106619 C2 UA 106619C2
Authority
UA
Ukraine
Prior art keywords
producing
cyclopropanecarboxylic acid
biphenyl
halogen
halogen biphenyl
Prior art date
Application number
UAA201200649A
Other languages
English (en)
Russian (ru)
Inventor
Фаусто Піветті
Марія Джіоя Форнаретто
Марко Ре
Original Assignee
К'Єзі Фармачеутічі С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by К'Єзі Фармачеутічі С.П.А. filed Critical К'Єзі Фармачеутічі С.П.А.
Publication of UA106619C2 publication Critical patent/UA106619C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/54—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
    • B01J23/56—Platinum group metals
    • B01J23/58—Platinum group metals with alkali- or alkaline earth metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Винахід стосується способу отримання сполуки формули (ІА) EMBED ISISServer (ІА).
UAA201200649A 2009-08-04 2010-07-22 Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти UA106619C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167206 2009-08-04
PCT/EP2010/004481 WO2011015287A2 (en) 2009-08-04 2010-07-22 Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Publications (1)

Publication Number Publication Date
UA106619C2 true UA106619C2 (uk) 2014-09-25

Family

ID=41479261

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201200649A UA106619C2 (uk) 2009-08-04 2010-07-22 Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти

Country Status (21)

Country Link
US (1) US9056818B2 (uk)
EP (1) EP2462098B1 (uk)
JP (2) JP5996428B2 (uk)
KR (1) KR101737653B1 (uk)
CN (1) CN102596879B (uk)
AU (1) AU2010281069B2 (uk)
BR (1) BR112012002500A2 (uk)
CA (1) CA2769960C (uk)
DK (1) DK2462098T3 (uk)
ES (1) ES2437163T3 (uk)
HR (1) HRP20140032T1 (uk)
IL (1) IL217886A (uk)
MX (1) MX2012001411A (uk)
MY (1) MY152980A (uk)
PT (1) PT2462098E (uk)
RU (1) RU2540076C2 (uk)
SG (1) SG178239A1 (uk)
SI (1) SI2462098T1 (uk)
UA (1) UA106619C2 (uk)
WO (1) WO2011015287A2 (uk)
ZA (1) ZA201200821B (uk)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2133322A1 (en) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
CN102596879B (zh) * 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法
KR20130036210A (ko) 2010-04-01 2013-04-11 키에시 파르마슈티시 엣스. 피. 에이. 신규 다형체 및 염
US8975438B2 (en) * 2011-07-13 2015-03-10 Hoffmann-La Roche Inc. Process for the preparation of cyclohexanecarboxylic acid derivatives
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
EP2834214A1 (en) 2012-04-04 2015-02-11 Chiesi Farmaceutici S.p.A. Derivatives of 1-(2-halo-biphenyl-4-yl)- alkanecarboxylic acids for the treatment of neurodegenerative diseases
EP2818460A1 (en) * 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
CA2915773A1 (en) 2013-06-24 2014-12-31 Chiesi Farmaceutici S.P.A. Improved process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
AU2022338032A1 (en) 2021-08-31 2024-03-07 Cerespir Incorporated Co-crystals

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409176T1 (de) 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
ITMI20030311A1 (it) * 2003-02-21 2004-08-22 Chiesi Farma Spa Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
JP2005047842A (ja) * 2003-07-31 2005-02-24 Mitsubishi Chemicals Corp 有機化合物の製造方法
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
WO2006133559A1 (en) * 2005-06-14 2006-12-21 Merck Frosst Canada Ltd. Reversible inhibitors of monoamine oxidase a and b
DK2119703T3 (da) * 2007-01-15 2013-01-14 Santen Pharmaceutical Co Ltd Nyt indolderivat med inhiberende virkning på I-B-kinase.
EP2133322A1 (en) 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
CN102596879B (zh) * 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法

Also Published As

Publication number Publication date
HK1168588A1 (en) 2013-01-04
ES2437163T3 (es) 2014-01-09
WO2011015287A2 (en) 2011-02-10
US9056818B2 (en) 2015-06-16
JP5996428B2 (ja) 2016-09-21
AU2010281069A1 (en) 2012-02-23
CN102596879A (zh) 2012-07-18
AU2010281069B2 (en) 2015-09-10
SI2462098T1 (sl) 2014-01-31
ZA201200821B (en) 2013-05-29
WO2011015287A3 (en) 2011-03-31
RU2540076C2 (ru) 2015-01-27
BR112012002500A2 (pt) 2018-03-13
DK2462098T3 (da) 2013-11-25
PT2462098E (pt) 2013-12-04
CA2769960A1 (en) 2011-02-10
KR101737653B1 (ko) 2017-05-18
CN102596879B (zh) 2015-01-28
HRP20140032T1 (hr) 2014-02-14
MX2012001411A (es) 2012-03-29
EP2462098A2 (en) 2012-06-13
CA2769960C (en) 2017-04-18
JP2013501010A (ja) 2013-01-10
IL217886A (en) 2014-11-30
JP6001112B2 (ja) 2016-10-05
RU2012104795A (ru) 2013-09-10
MY152980A (en) 2014-12-15
EP2462098B1 (en) 2013-10-23
IL217886A0 (en) 2012-03-29
JP2015131824A (ja) 2015-07-23
KR20120050977A (ko) 2012-05-21
SG178239A1 (en) 2012-03-29
US20110039934A1 (en) 2011-02-17

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