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UA106361C2 - Фармацевтическая композиция для лечения эссенциальной тромбоцитемии - Google Patents

Фармацевтическая композиция для лечения эссенциальной тромбоцитемии

Info

Publication number
UA106361C2
UA106361C2 UAA201108389A UAA201108389A UA106361C2 UA 106361 C2 UA106361 C2 UA 106361C2 UA A201108389 A UAA201108389 A UA A201108389A UA A201108389 A UAA201108389 A UA A201108389A UA 106361 C2 UA106361 C2 UA 106361C2
Authority
UA
Ukraine
Prior art keywords
anagrelide
pharmaceutical composition
treatment
essential thrombocythemia
particles
Prior art date
Application number
UAA201108389A
Other languages
English (en)
Ukrainian (uk)
Inventor
Рудольф Видманн
Original Assignee
Аоп Орфан Фармацейтикалс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аоп Орфан Фармацейтикалс Аг filed Critical Аоп Орфан Фармацейтикалс Аг
Publication of UA106361C2 publication Critical patent/UA106361C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к фармацевтической композиции в форме таблетки или капсулы, включающей частицы анагрелида и по меньшей мере 60 мг моногидрата лактозы, при этом по меньшей мере 90 % указанных частиц анагрелида имеют диаметр меньше 10 мкм, которая в комбинации с моногидратом лактозы позволяет получить лекарственную форму со сниженными характеристиками высвобождения при приеме пациентом. Также указанная композиция может дополнительно содержать повидон, кросповидон, микрокристаллическую целлюлозу и/или стеарат магния. Кроме того, изобретение относится к применению указанной выше фармацевтической композиции и способу лечения эссенциальной тромбоцитемии указанной выше фармацевтической композицией.
UAA201108389A 2008-12-05 2009-12-04 Фармацевтическая композиция для лечения эссенциальной тромбоцитемии UA106361C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0070708U AT10562U3 (de) 2008-12-05 2008-12-05 Neuartige zusammensetzung zur behandlung einer essenziellen thrombozytämie
PCT/EP2009/066405 WO2010063824A1 (en) 2008-12-05 2009-12-04 Novel composition for treatment of essential thrombocythemia

Publications (1)

Publication Number Publication Date
UA106361C2 true UA106361C2 (ru) 2014-08-26

Family

ID=40550008

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201108389A UA106361C2 (ru) 2008-12-05 2009-12-04 Фармацевтическая композиция для лечения эссенциальной тромбоцитемии

Country Status (19)

Country Link
EP (1) EP2367539B1 (ru)
KR (1) KR101631728B1 (ru)
CN (1) CN102307572B (ru)
AT (1) AT10562U3 (ru)
AU (1) AU2009324043B2 (ru)
CY (1) CY1114306T1 (ru)
DK (1) DK2367539T3 (ru)
EA (1) EA022715B1 (ru)
ES (1) ES2426232T3 (ru)
HR (1) HRP20130647T1 (ru)
IL (1) IL213198A (ru)
MY (1) MY155660A (ru)
PL (1) PL2367539T3 (ru)
PT (1) PT2367539E (ru)
SG (1) SG171979A1 (ru)
SI (1) SI2367539T1 (ru)
UA (1) UA106361C2 (ru)
WO (1) WO2010063824A1 (ru)
ZA (1) ZA201103409B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012011051A (es) * 2010-03-25 2013-01-29 Aop Orphan Pharmaceuticals Ag Composicion novedosa para el tratamiento de trombocitemia esencial.
EP2915526B1 (en) 2014-03-07 2021-06-02 Galenicum Health S.L.U. Pharmaceutical compositions comprising anagrelide
PT3236967T (pt) * 2014-12-22 2020-01-06 Suda Pharmaceuticals Ltd Prevenção e tratamento de doença metastática em pacientes com cancro trombocitóticos
WO2022060309A1 (en) * 2020-09-18 2022-03-24 İlko İlaç Sanayi̇ Ve Ti̇caret A.Ş. Long-term stable anagrelid capsule composition
WO2024189275A1 (en) 2023-03-15 2024-09-19 Sartar Therapeutics Oy A pharmaceutical composition for subcutaneous injection of anagrelide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287599B1 (en) * 2000-12-20 2001-09-11 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
US6811794B2 (en) * 2001-12-20 2004-11-02 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
US20050008704A1 (en) * 2003-07-11 2005-01-13 Ray Anup Kumar Pharmaceutical composition for solubility enhancement of hydrophobic drugs
WO2005112917A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
WO2005107719A2 (en) * 2004-05-06 2005-11-17 Sandoz Ag Pharmaceutical composition comprising hydrophobic drug having improved solubility
EP1871345B1 (en) * 2005-04-12 2012-08-01 Elan Pharma International Limited Nanoparticulate erlotinib formulations
US20070104782A1 (en) * 2005-07-28 2007-05-10 Ibrahim Melissa E Modified release tablet formulations with enhanced mechanical properties
JP2009502957A (ja) * 2005-07-28 2009-01-29 スパーナス ファーマシューティカルズ インコーポレイテッド 機械的特性の向上した徐放性錠剤配合物
BRPI0807807A2 (pt) * 2007-01-25 2014-06-17 Panacea Biotec Ltd " composição farmacêutica de liberação modificada e um processo para fabricar a mesma ".

Also Published As

Publication number Publication date
HRP20130647T1 (en) 2013-08-31
HK1158957A1 (en) 2012-07-27
DK2367539T3 (da) 2013-08-26
EA201170583A1 (ru) 2011-12-30
MY155660A (en) 2015-11-13
CY1114306T1 (el) 2016-08-31
KR20110106280A (ko) 2011-09-28
SG171979A1 (en) 2011-07-28
IL213198A0 (en) 2011-07-31
EP2367539A1 (en) 2011-09-28
PT2367539E (pt) 2013-09-09
SI2367539T1 (sl) 2013-09-30
ES2426232T3 (es) 2013-10-22
AT10562U3 (de) 2010-01-15
EP2367539B1 (en) 2013-06-05
IL213198A (en) 2015-09-24
EA022715B1 (ru) 2016-02-29
CN102307572B (zh) 2015-04-08
AU2009324043A1 (en) 2010-06-10
WO2010063824A1 (en) 2010-06-10
CN102307572A (zh) 2012-01-04
AU2009324043B2 (en) 2016-02-25
ZA201103409B (en) 2012-07-25
AT10562U2 (de) 2009-06-15
PL2367539T3 (pl) 2013-10-31
KR101631728B1 (ko) 2016-06-17

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