TWM469045U - A dual wavelength cartilage repairing phototherapy device using nanogold mixed biological gel - Google Patents
A dual wavelength cartilage repairing phototherapy device using nanogold mixed biological gel Download PDFInfo
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- TWM469045U TWM469045U TW102216391U TW102216391U TWM469045U TW M469045 U TWM469045 U TW M469045U TW 102216391 U TW102216391 U TW 102216391U TW 102216391 U TW102216391 U TW 102216391U TW M469045 U TWM469045 U TW M469045U
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- cartilage
- light
- light source
- output light
- cartilage repair
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- 210000000845 cartilage Anatomy 0.000 title claims abstract description 33
- 238000001126 phototherapy Methods 0.000 title claims abstract description 24
- 230000009977 dual effect Effects 0.000 title abstract description 3
- 230000003287 optical effect Effects 0.000 claims abstract description 13
- 239000000835 fiber Substances 0.000 claims abstract description 11
- 239000000523 sample Substances 0.000 claims abstract description 5
- 239000013307 optical fiber Substances 0.000 claims abstract description 4
- 230000005540 biological transmission Effects 0.000 claims description 10
- 238000005286 illumination Methods 0.000 claims description 9
- 108010027529 Bio-glue Proteins 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 125000004386 diacrylate group Chemical group 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920000671 polyethylene glycol diacrylate Polymers 0.000 claims description 3
- 239000000227 bioadhesive Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical compound C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- 229920000805 Polyaspartic acid Polymers 0.000 description 2
- 210000001188 articular cartilage Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 108010064470 polyaspartate Proteins 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002073 nanorod Substances 0.000 description 1
- 239000002078 nanoshell Substances 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
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- Radiation-Therapy Devices (AREA)
Abstract
Description
本創作係有關於一種雷射骨科治療儀，尤指一種使用奈米金生物膠之雙波長軟骨修復光療儀。This creation is about a laser orthopedic treatment device, especially a dual-wavelength cartilage repair phototherapy instrument using nano gold bio glue.
退化性關節炎所引起的關節軟骨細胞外基質缺損在臨床上十分常見。因為軟骨細胞屬於增殖能力極弱的終末分化細胞，缺乏再生能力，軟骨創傷後的修復甚為困難，軟骨缺損或損傷一直是外科臨床治療的一大難題。利用智慧型高分子水膠與組織工程技術促進組織再生，已成為治療關節軟骨病變的方法。智慧型水膠能應答環境，例如光或溫度等的微小變化而發生可逆性體積相轉變或溶膠-凝膠相轉變(phase transition)，已被廣泛應用於定點控制藥物釋放與組織工程研究。Articular cartilage extracellular matrix defects caused by degenerative arthritis are clinically very common. Because chondrocytes are terminally differentiated cells with extremely weak proliferative capacity, lack of regenerative capacity, and repair after cartilage trauma is very difficult. Cartilage defects or injuries have always been a major problem in surgical clinical treatment. The use of smart polymer water gel and tissue engineering technology to promote tissue regeneration has become a method for the treatment of articular cartilage lesions. Smart water gel can respond to the environment, such as light or temperature changes such as reversible volume phase transition or sol-gel phase transition, has been widely used in fixed-point control drug release and tissue engineering research.
目前技術使用溫度敏感性水膠，依賴人體溫產生凝膠，或使用光敏感性水膠，透過紫外(UV)光聚合而形成水膠。先前技術缺少定量溫控及可調速之光聚合。再則，目前技術均使用單一波長光源連續式出光，其紫外光能量滲透深度受限。At present, the technology uses temperature-sensitive water gel, which relies on human body temperature to produce a gel, or uses a light-sensitive water gel to form a water gel by ultraviolet (UV) photopolymerization. Prior art lacks quantitative temperature control and adjustable speed photopolymerization. Furthermore, the current technology uses a single-wavelength light source to continuously emit light, and its ultraviolet light energy penetration depth is limited.
鑒于上述之先前技術背景，本創作之目的是，提出一個新的軟骨修復光療儀，結合奈米金及生物膠並使用雙波長技術。該技術提供包括定量定時溫控及可調速之紫藍光聚合或红外光膠凝等多方面優勢，這些都是先前技術達不到的。In view of the above prior art background, the purpose of this creation is to propose a new cartilage repair phototherapy instrument that combines nanogold and bioglue and uses dual wavelength technology. The technology provides advantages such as quantitative timed temperature control and adjustable speed violet blue or infrared gelation, which are not available in the prior art.
本創作係提供一種使用奈米金生物膠之雙波長軟骨修復光療儀。該軟骨光療儀包括：一個或兩個光源器，一電源器，一面板控制顯示。該光源器輸出光經由一光學鏡片組或光纖或手柄輸出。也可經由一傳輸內視鏡將能量傳輸到到軟骨修復治療部位。該光源器包括近紅外雷射或LED光源(波長750到980奈米)，也可包括紫藍光源(波長350到460奈米)。詳情見下列實施例。This creation provides a dual-wavelength cartilage repair phototherapy device using nanogold bioglue. The cartilage phototherapy apparatus comprises: one or two light sources, a power supply, and a panel control display. The light source output light is output via an optical lens set or fiber optic or handle. Energy can also be delivered to the cartilage repair treatment site via a transmission endoscope. The light source includes a near-infrared laser or LED light source (wavelength 750 to 980 nm), and may also include a violet-blue light source (wavelength 350 to 460 nm). See the following examples for details.
(10)(100)‧‧‧電源器(10) (100)‧‧‧ Power supply
(11，12)‧‧‧面板控制顯示(11,12)‧‧‧ Panel Control Display
(13)‧‧‧手動開關(13)‧‧‧Manual switch
(14)‧‧‧腳踏開關(14)‧‧‧ Foot switch
(15)‧‧‧電源線(15)‧‧‧Power cord
(20)‧‧‧光源器(20)‧‧‧Light source
(30)‧‧‧光學鏡片組(30)‧‧‧Optical lens group
(21)(104)‧‧‧輸出光(21) (104)‧‧‧ Output light
(30)‧‧‧光學鏡片組(30)‧‧‧Optical lens group
(21)‧‧‧輸出光(21)‧‧‧ Output light
(22)‧‧‧聚透鏡(22)‧‧‧Glenoptic lens
(22)‧‧‧正透鏡(22) ‧‧‧ positive lens
(32)‧‧‧負透鏡(32)‧‧‧negative lens
(103)‧‧‧光學光纖(103)‧‧‧Optical fiber
(30)‧‧‧手柄(30) ‧‧‧handle
(201)‧‧‧傳輸光纖(201)‧‧‧Transmission fiber
(202)‧‧‧傳輸內視鏡(202)‧‧‧Transmission of endoscopes
(200)‧‧‧人體(200) ‧ ‧ human body
(203)‧‧‧軟骨修復治療部位(203) ‧‧‧Cartilage repair treatment site
(204)‧‧‧注射針筒(204)‧‧‧Injection syringe
(205)‧‧‧光纖探頭(205)‧‧‧Fiber Optic Probe
(206)‧‧‧觀察內視鏡(206) ‧‧‧Viewing endoscopes
圖1係本創作之系統平面結構示意圖。Figure 1 is a schematic diagram of the planar structure of the system of the present creation.
圖2係本創作之光學鏡片組示意圖。Figure 2 is a schematic view of the optical lens set of the present invention.
圖3係本創作另一種系統平面結構示意圖。Figure 3 is a schematic diagram of another system planar structure of the present invention.
圖4係本創作另一種系統結構示意圖。Figure 4 is a schematic diagram of another system structure of the present creation.
如圖1所示本創作係提供一種軟骨光療儀，該軟骨光療儀包括：一電源器(10)及面板控制顯示(11，12)，該電源器(10)經由一電源線(15)連接到光源器(20)， 該光源器(20)輸出光(21)經由光學鏡片組(30)控制其在被治療部位輸出光斑之大小。該光療儀照射時間之控制包括：手動開關(13)，面板控制(11)或腳踏開關(14)。該面板控制參數包括：輸出光照射時間顯示(11)，輸出光功率顯示(12)，以及照射方式(圖1未顯示)。該照射方式可為連續式或脈沖，脈沖寬為0.001秒到2秒，照射時間範圍10秒到600秒。該光源器(20)包括紫藍光雷射或LED光源，該輸出光(104)包括波長範圍350到460奈米。As shown in Fig. 1, the present invention provides a cartilage phototherapy apparatus comprising: a power supply (10) and a panel control display (11, 12), the power supply (10) being connected via a power line (15) To the light source (20), The light source (20) outputs light (21) to control the size of the output spot at the treated site via the optical lens set (30). The control of the phototherapy apparatus illumination time includes: a manual switch (13), a panel control (11) or a foot switch (14). The panel control parameters include: output light illumination time display (11), output light power display (12), and illumination mode (not shown in Figure 1). The irradiation mode may be continuous or pulsed, the pulse width is 0.001 second to 2 seconds, and the irradiation time ranges from 10 seconds to 600 seconds. The light source (20) comprises a violet blue laser or LED light source, the output light (104) comprising a wavelength range of 350 to 460 nm.
如圖2所示該光學鏡片組(30)經由一個聚透鏡(22)位置移動距離(L)改變輸出光(21)在被治療部位之光斑大小，該光斑大小也可由被治療部位不同作用位置(R1,R2)而定。如圖-2所示該光學鏡片組也可包括一組正透鏡(22)及負透鏡(32)組成，經由負透鏡(32)位置移動距離(L)調節該光斑大小。上述聚透鏡(22)，正透鏡(22)及負透鏡(32)焦距範圍為0.5到10公分，該光斑在被治療部位直徑範圍為1.0到20毫米。As shown in FIG. 2, the optical lens group (30) changes the spot size of the output light (21) at the treated site via a poly lens (22) position moving distance (L), and the spot size can also be different from the treated site. (R1, R2). As shown in FIG. 2, the optical lens group may also include a set of positive lens (22) and negative lens (32), and the spot size is adjusted by a negative lens (32) position moving distance (L). The above-mentioned polylens (22), positive lens (22) and negative lens (32) have a focal length ranging from 0.5 to 10 cm, and the spot has a diameter ranging from 1.0 to 20 mm at the site to be treated.
如圖3所示該該軟骨光療儀包括：一光源器(100)及面板控制顯示(11，12)。該光源器(100)經由一個光纖偶合器(圖3未顯示)將其輸出光(104)與一光學光纖(103)及一個內置有光學鏡片組(圖3未顯示)之手柄(30)連接。該面板控制參數包括：輸出光照射時間顯示(101)，輸出光功率顯示(102)，以及照射方式(圖3未顯示)。該照射方式可為連續式或脈沖，脈沖寬為0.001秒到2秒，照射時間範圍10秒到600秒。該光源器(100)包括近紅外雷射或LED光源，該輸出光(104)包括波長範圍750到980奈米。該光源器(100)也可包括紫藍光雷射或LED光源，該輸出光(104)包括波長範圍350到460奈米。As shown in FIG. 3, the cartilage phototherapy apparatus comprises: a light source (100) and a panel control display (11, 12). The light source (100) connects its output light (104) to an optical fiber (103) and a handle (30) having an optical lens set (not shown in FIG. 3) via a fiber coupler (not shown in FIG. 3). . The panel control parameters include an output light illumination time display (101), an output light power display (102), and an illumination mode (not shown in FIG. 3). The irradiation mode may be continuous or pulsed, the pulse width is 0.001 second to 2 seconds, and the irradiation time ranges from 10 seconds to 600 seconds. The light source (100) includes a near infrared laser or LED light source, the output light (104) comprising a wavelength range of 750 to 980 nm. The light source (100) may also include a violet blue laser or LED light source, the output light (104) comprising a wavelength range of 350 to 460 nm.
如圖4所示該軟骨光療儀包括一個或兩個光源器(10)及(100)，其輸出光經由傳輸光纖(201)及一傳輸內視鏡(202)將能量傳輸到到人體(200)軟骨修復治療部位(203)。該軟骨光療儀也可包括一個內有光感型或溫感型生物膠注射針筒(204)。該注射針筒(204)生物膠經由該內視鏡(202)傳輸到軟骨修復治療部位(203)。該生物膠包括光感型雙丙烯酸聚乙二醇酯(PEGDA)，或摻合奈米金棒(rod)或奈米金殼(shell)溫感型之聚天冬醯胺(PNA)水膠或類似功能之親水性生物膠。該軟骨光療儀也可包括內有紅外線光纖探頭(205)之另一個觀察內視鏡(206)用以定位或觀察軟骨修復情況。該軟骨光療儀之該傳輸內視鏡(202)也可同時通過一傳輸光纖(201)，一生物膠注射針筒(205)及一紅外線光纖探頭(205)。As shown in FIG. 4, the cartilage phototherapy apparatus includes one or two light sources (10) and (100), and the output light transmits energy to the human body via the transmission fiber (201) and a transmission endoscope (202). Cartilage repair treatment site (203). The cartilage phototherapy apparatus can also include a bio-sensitive or temperature-sensitive bio-gel injection syringe (204). The syringe (204) biogel is delivered to the cartilage repair treatment site (203) via the endoscope (202). The bio-adhesive includes photo-sensitive polyethylene glycol diacrylate (PEGDA), or a blend of nano-rod or nano-shell warm-type polyaspartic acid (PNA) water gel or Hydrophilic bioglue with similar functions. The cartilage phototherapy apparatus can also include another viewing endoscope (206) with an infrared fiber optic probe (205) for positioning or observing cartilage repair. The transmission endoscope (202) of the cartilage phototherapy apparatus can also pass through a transmission fiber (201), a bio-injection syringe (205) and an infrared fiber probe (205).
該光感型雙丙烯酸聚乙二醇酯(PEGDA)經由光療儀之紫藍光聚合。另一方面，該摻合奈米金溫感型之聚天冬醯胺(PNA)則經由光療儀之红外光(IR)產生膠凝。經由控制照射光功率，照射时间及其照射方式，即可达到定量定时及可调速度之光聚合或膠凝。該紫藍或红外輸出光在軟骨修復治療部位之功率範圍0.1瓦到10瓦，依治療部位直徑範圍(1.0到20毫米)而定。治療部位照射時間範圍10秒到600秒。The photo-sensitive polyethylene glycol diacrylate (PEGDA) is polymerized by violet blue light of a phototherapy apparatus. On the other hand, the blended nanogold warm-sensing polyaspartic acid (PNA) is gelled by infrared light (IR) of a phototherapy apparatus. Photopolymerization or gelation at a quantitative timing and an adjustable speed can be achieved by controlling the power of the illumination light, the irradiation time, and the manner of irradiation. The power of the purple-blue or infrared output light in the cartilage repair treatment site ranges from 0.1 watt to 10 watts, depending on the diameter of the treatment site (1.0 to 20 mm). The treatment site irradiation time ranges from 10 seconds to 600 seconds.
(10)‧‧‧電源器(10)‧‧‧Power supply
(11，12)‧‧‧面板控制顯示(11,12)‧‧‧ Panel Control Display
(13)‧‧‧手動開關(13)‧‧‧Manual switch
(14)‧‧‧腳踏開關(14)‧‧‧ Foot switch
(15)‧‧‧電源線(15)‧‧‧Power cord
(20)‧‧‧光源器(20)‧‧‧Light source
(30)‧‧‧光學鏡片組(30)‧‧‧Optical lens group
(21)‧‧‧輸出光(21)‧‧‧ Output light
Claims (7)
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| TW102216391U TWM469045U (en) | 2013-08-30 | 2013-08-30 | A dual wavelength cartilage repairing phototherapy device using nanogold mixed biological gel |
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| Application Number | Priority Date | Filing Date | Title |
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| TW102216391U TWM469045U (en) | 2013-08-30 | 2013-08-30 | A dual wavelength cartilage repairing phototherapy device using nanogold mixed biological gel |
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| TWM469045U true TWM469045U (en) | 2014-01-01 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110681062A (en) * | 2019-09-28 | 2020-01-14 | 复旦大学 | Auxiliary phototherapy equipment for bone defect repair |
| US11202674B2 (en) | 2018-04-03 | 2021-12-21 | Convergent Dental, Inc. | Laser system for surgical applications |
| US11389663B2 (en) | 2011-04-01 | 2022-07-19 | Bioregentech, Inc. | Laser assisted wound healing protocol and system |
| TWI782537B (en) * | 2021-05-21 | 2022-11-01 | 國立臺灣科技大學 | Light supply method and light supply system for phototherapy |
| US11654293B2 (en) * | 2016-11-10 | 2023-05-23 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
| US11730760B2 (en) | 2011-04-01 | 2023-08-22 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
| US11745026B2 (en) * | 2011-04-01 | 2023-09-05 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
-
2013
- 2013-08-30 TW TW102216391U patent/TWM469045U/en not_active IP Right Cessation
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11389663B2 (en) | 2011-04-01 | 2022-07-19 | Bioregentech, Inc. | Laser assisted wound healing protocol and system |
| US11684797B2 (en) | 2011-04-01 | 2023-06-27 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
| US11730760B2 (en) | 2011-04-01 | 2023-08-22 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
| US11745026B2 (en) * | 2011-04-01 | 2023-09-05 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
| US11654293B2 (en) * | 2016-11-10 | 2023-05-23 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
| US11202674B2 (en) | 2018-04-03 | 2021-12-21 | Convergent Dental, Inc. | Laser system for surgical applications |
| CN110681062A (en) * | 2019-09-28 | 2020-01-14 | 复旦大学 | Auxiliary phototherapy equipment for bone defect repair |
| TWI782537B (en) * | 2021-05-21 | 2022-11-01 | 國立臺灣科技大學 | Light supply method and light supply system for phototherapy |
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