TWI845581B - Pest repellent composition - Google Patents

Abstract

The pest repellent composition of the present invention contains the following components (A) and (B): (A) at least one non-volatile liquid oil component selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, fatty alcohol and polyol, having a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa·s or less at 23°C measured by a B-type rotational viscometer: 13 mass % or more and 99.995 mass % or less; (B) at least one repellent component selected from N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005 mass % or more and 3 mass % or less.

Description

Pest repellent composition

The present invention relates to a pest repellent composition.

Pests such as mosquitoes, flies and other flying pests can transmit pathogens to humans and other animals, causing infections or dermatitis. In particular, some mosquito species transmit pathogens such as dengue fever, Zika fever, yellow fever, encephalitis, and malaria, making them very harmful insects in terms of hygiene. Previously, in order to avoid being invaded by such flying pests, the common method was to spread insecticides or apply repellents on the skin. As a representative repellent, DEET (N,N-diethyltoluamide) is generally used.

Pests such as mosquitoes have chemical receptors that sense animal body temperature, olfactory receptors that sense volatile substances such as body odor, and carbon dioxide receptors that sense carbon dioxide, which are used to detect animals. DEET modulates the chemical receptors of the pests to weaken their cognitive senses, thereby repelling them. However, DEET has an unpleasant odor, and in order to exert a sufficient and lasting repellent effect, it must be formulated in a certain amount. Furthermore, it is known that it can cause allergies or skin chapped skin depending on the individual, and there is a problem of limited usage or frequency for young children or people with sensitive skin.

Therefore, some studies have been conducted to use natural essential oils as repellent ingredients. Natural essential oils such as citronella oil, lemon eucalyptus oil, lemongrass oil, orange peel oil, and cinnamon oil are also used in candles or aromatherapy lotions and are safer for the human body. However, the repellent effect of these products on pests is not sufficient and their practicality is questionable.

In addition, various proposals have been made for repellents or repellent compositions for insects. For example, Patent Document 1 describes the formulation of insect repellents such as DEET in a skin protectant formulated with fluorine-polyether co-modified polysilicone and a UV protection component. Patent Document 2 describes the enhancement of the insect repellent effect by combining a pest repellent component containing ethyl 3-(acetylbutyl)aminopropionate and/or N,N-diethyltoluamide with an antibacterial compound. [Prior Art Document] [Patent Document]

Patent document 1: Japanese Patent Publication No. 8-59447 Patent document 2: Japanese Patent Publication No. 2016-102092

The present invention provides the following [1] to [7]. [1] A pest repellent composition or pest residence inhibiting composition comprising the following components (A) and (B): (A) having a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 at 23°C as measured by a B-type rotational viscometer. mPa・s or less, one or more non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 99.995 mass% or less (B) One or more taboo components selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.005 mass% or more and 3 mass% or less [2] A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (C), wherein the content of the pest repellent other than components (A) and (B) is 15% by mass or less, and (A) has a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 at 23°C as measured by a B-type rotational viscometer. mPa・s or less non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 50 mass% or less; (B) 1 or more taboo components selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.01 mass% or more and 3 mass% or less; (C) Water: 35 mass% or more and 86.995 mass% or less. [3] A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (C), wherein the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, the content of pest repellents other than component (A) and component (B) is 15% by mass or less, and the surface tension of (A) at 25°C is 40 mN/m or less, and the viscosity at 23°C measured by a B-type rotational viscometer is 400 mPa・s or less non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 50 mass% or less; (B) One or more taboo ingredients selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.005 mass% or more and 3 mass% or less; (C) Water: 35 mass% or more and 86.995 mass% or less. [4] A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (C), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 to 3000, the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, the content of pest repellent other than components (A) and (B) is 15% by mass or less, and the surface tension of (A) at 25°C is 40 mN/m or less, and the viscosity at 23°C measured by a B-type rotational viscometer is 400 mPa・s or less non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 50 mass% or less; (B) One or more taboo ingredients selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.005 mass% or more and 3 mass% or less; (C) Water: 35 mass% or more and 86.995 mass% or less. [5] A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (D), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 to 3000, the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, the content of pest repellents other than components (A) and (B) is 15% by mass or less, and the surface tension of (A) at 25°C is 40 mN/m or less, and the viscosity at 23°C measured by a B-type rotational viscometer is 400 mPa・s or less; (B) one or more non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil and hydrocarbon oil: 13% to 50% by mass; (B) one or more repellent components selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% to 3% by mass; (C) water: 35% to 86.995% by mass; (D) thickener: 0.05% to 5% by mass. [6] A method for repelling pests, which comprises applying a composition as described in any one of [1] to [5] to the surface of human skin. [7] A method for inhibiting the residence of pests, which comprises preventing the pests from residing on human skin by allowing a composition as described in any one of [1] to [5] to adhere to the body of the pest.

[Pest repellent composition, pest residence inhibiting composition] The pest repellent composition and pest residence inhibiting composition of the present invention (hereinafter collectively referred to as "the composition of the present invention") are compositions containing the following components (A) and (B). (A) Non-volatile liquid oily component selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, fatty alcohol and polyol, with a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa・s or less at 23°C measured by a B-type rotational viscometer: 13% by mass or more and 99.995% by mass or less (B) Repellent active ingredient selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% by mass or more and 3% by mass or less

The composition of the present invention contains specific amounts of component (A) and component (B), has excellent and lasting repellent effect on pests, especially flying pests, has less unpleasant odor originating from specific repellent components, and is suitable for skin application.

Regarding the insect repellents for skin application, it is expected to be safe and have less odor, and not only the initial repellent effect but also the duration of the repellent effect is excellent. However, the current main insect repellents available cannot fully meet these expectations. As mentioned above, the existing insect repellents such as DEET described in patent documents 1 and 2 have an unpleasant odor and also have problems with their safety to the human body. Therefore, repellents that can be used more safely by young children or people with sensitive skin are required. At present, a composition suitable for skin application that has excellent pest repellent effect and duration and suppresses the unpleasant odor derived from the repellent component has not been found.

The subject of the present invention is to provide a pest repellent composition which has excellent and lasting repellent effect on pests, especially flying pests, is safe, has less unpleasant odor from repellent ingredients, and is suitable for skin application.

The inventors of the present invention have conducted intensive research and found that non-volatile liquid oily components with specific surface tension and viscosity have the effect of repelling mosquitoes and other pests, but when actually used on human skin, the duration of the repellent effect still needs further research. Therefore, it was found that if the content of existing pest repellent components such as N,N-diethyltoluamide is set to a level that does not constitute an unpleasant odor problem and combined with a non-volatile liquid oily component with specific surface tension and viscosity, not only the unpleasant odor can be suppressed, but also the repellent effect can be prolonged. That is, it has been found that a pest repellent composition containing a specific amount of a non-volatile liquid oil component having a specific surface tension and viscosity, and a repellent component such as N,N-diethyltoluamide can solve the above-mentioned problem. According to the present invention, a pest repellent composition, a pest residence inhibiting composition, a pest repellent method, and a pest residence inhibiting method can be provided, which has an excellent and lasting repellent effect on pests, especially flying pests, is safe, has less unpleasant odor from specific repellent components, and is suitable for skin application.

In the present invention, the so-called "repellent effect on pests" means that even if pests come into contact with an object, they will not stay but will leave immediately. The composition of the present invention is equivalent to a contact repellent composition. That is, the pest repellent effect in the present invention is different from repellents or insect repellents that achieve the purpose of repelling by non-contact with the object, such as preventing pests from approaching the object or preventing pests from approaching the object, or insecticides that have insecticide power against pests and repel pests. The composition of the present invention exerts the effect of repelling pests by not staying on the spot but leaving immediately even if pests such as mosquitoes land on the object applied or attached with the composition. Specifically, it has the following stay inhibition effect: after mosquitoes and other pests land on the skin of humans and other animals, they will not stay in a specific area on the skin surface for about the time required for the needle to be inserted, specifically more than 1 second. This effect is based on the previously unknown pest repellent principle, and is relatively safe, without side effects such as skin chapped skin. Therefore, the composition of the present invention can be used as a pest stay inhibition composition. In the present invention, the so-called "sustained repellent effect on pests" means that after the composition of the present invention is applied to the object, even after a period of time, the above repellent effect remains effective. Furthermore, in the following description, the sustained repellent effect of the present invention, especially for flying pests, is briefly described as "sustained repellent effect".

The composition of the present invention contains as component (A) a non-volatile liquid oil component selected from the group consisting of (a) silicone oil, (b) ester oil, (c) ether oil, (d) hydrocarbon oil, (e) fatty alcohol and (f) polyol, with a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa·s or less at 23°C measured by a B-type rotational viscometer. By containing component (A), the repellent effect on pests, especially flying pests, is excellent and lasting. The reason has not been determined, but it is believed to be as follows. The inventors of the present invention have found that flying pests such as mosquitoes have the following characteristics: in order to avoid the gravitational force generated by the landing surface when the limbs are wetted, they will avoid staying on the surface that will wet the limbs. Since the limbs of flying pests such as mosquitoes are hydrophobic, if the surface tension at 25°C is 40 mN/m or less, the affinity with the limbs of flying pests becomes higher. Moreover, if the viscosity is 400 mPa・s or less, when the limbs of flying pests come into contact with the liquid oily component, the contact area between the liquid oily component and the limbs of flying pests becomes sufficiently large in a short time. Therefore, it is believed that if a flying pest lands on a surface coated or attached with component (A), its limbs will be wetted, and at this time it will avoid the gravitational force generated by the landing surface and fly away without staying at the landing site. Furthermore, the so-called landing in the present invention refers to the time when the flying pests such as mosquitoes and the object are in contact with each other for less than 1 second. Moreover, the so-called staying in the present invention refers to the time when the flying pests such as mosquitoes and the object are in contact with each other for more than 1 second.

Furthermore, if the composition of the present invention contains only component (A), there is still room for improvement in terms of sufficient and lasting repellent effect in actual use. Therefore, in addition to component (A), a specific amount of component (B) is further contained. It is believed that by applying component (A) and component (B) together to the body of flying pests, the unpleasant odor originating from component (B) can be reduced while achieving an excellent and lasting repellent effect.

<Ingredient (A): non-volatile liquid oil component> The component (A) contained in the composition of the present invention is a non-volatile liquid oil component having a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa・s or less at 23°C measured by a B-type rotational viscometer, selected from the group consisting of (a) silicone oil, (b) ester oil, (c) ether oil, (d) hydrocarbon oil, (e) aliphatic alcohol and (f) polyol.

In terms of easy application to the skin and improved repellent effect, ingredient (A) is preferably a non-volatile oil that is liquid at 20°C, more preferably at 15°C, and further preferably at 10°C. In addition, the so-called "liquid" of the liquid oily ingredient means that it is determined to be liquid according to the liquid-solid determination test based on the American Society for Testing and Materials standard "ASTM D 4359-90: Standard Test Method for Determining Whether a Material is a Liquid or Solid". In terms of enhancing the sustained repellent effect on pests, component (A) is preferably a poorly water-soluble or water-insoluble component. Specifically, the amount of component (A) dissolved in 100 g of water at 20° C. is preferably 1 g or less, more preferably 0.5 g or less, further preferably 0.1 g or less, and further preferably substantially 0 g or more.

The liquid oil component of component (A) used in the present invention is a non-volatile liquid oil component from the viewpoint of enhancing the lasting repellent effect. Here, the so-called non-volatile liquid oil component in the present invention refers to a component having a volatility of less than 50% at 1 atmosphere, 25°C, and after drying for 60 minutes, preferably a component having a volatility of less than 50% at 1 atmosphere, 25°C, and after drying for 120 minutes. The evaluation of volatility is measured in accordance with the German test standard DIN53249. Specifically, it is carried out according to the following procedures 1 to 4. 1. Measure the weight (P (g)) of a circular filter paper with a diameter of 150 mm. 2. Use a pipette to drop 0.3 g of the sample of component (A) onto the round filter paper, and then immediately measure the weight of the filter paper (W ₀ (g)). 3. Under airtight conditions, measure the weight of the filter paper by weight measurement with an accuracy of approximately 0.001 g at 25°C after an interval of 5 minutes. The weight of the filter paper measured 60 minutes after the measurement in procedure 2 is set as W ₆₀ (g). 4. The value derived by the calculation formula {((W ₀ －P)－(W ₆₀ －P))/(W ₀ －P)}×100 is taken as the volatility (%). The lower the volatility, the longer the retention time of the liquid oily component when applied to the skin, and therefore the higher the repellent effect. When two or more liquid oily components are used, the volatility of the non-volatile liquid oily component refers to the volatility of the mixture of the two or more liquid oily components. Therefore, as long as the volatility of the mixture is within the above range, liquid oily components with a volatility exceeding 50% after drying at 1 atmosphere and 25°C for 60 minutes may be used in combination.

The surface tension of component (A) at 25°C is preferably 15 mN/m or more, more preferably 17 mN/m or more from the viewpoint of availability, and is 40 mN/m or less, preferably 30 mN/m or less, more preferably 28 mN/m or less, further preferably 25 mN/m or less, further preferably 23 mN/m or less, further preferably 21 mN/m or less from the viewpoint of improving the repellent lasting effect. Moreover, even if the surface tension of the component itself at 25°C exceeds 40 mN/m, if the surface tension can be reduced by making a mixture with other liquid oily components, the repellent lasting effect can also be exhibited. The viscosity of component (A) at 23°C measured by a B-type rotational viscometer is preferably 1 mPa·s or more from the viewpoint of suppressing volatility and improving the lasting effect of repellent, and is preferably 400 mPa·s or less from the viewpoint of improving the lasting effect of repellent, preferably 300 mPa·s or less, more preferably 210 mPa·s or less, further preferably 100 mPa·s or less, further preferably 60 mPa·s or less, further preferably 40 mPa·s or less, further preferably 30 mPa·s or less. Furthermore, when two or more liquid oily components with different viscosities are used, it means the viscosity of the mixture of the liquid oily components. Furthermore, the surface tension and viscosity of component (A) are measured by the method described in the embodiment.

(a) Silicone oil From the perspective of improving the lasting effect of repelling, the silicone oil is preferably one or more selected from the group consisting of dimethyl polysiloxane, dimethiconol (dimethyl polysiloxane having a hydroxyl group at the end), methylphenyl polysiloxane and modified polysiloxane. Examples of modified silicone include amino-modified silicone (dimethyl silicone containing an amino group in the molecule), polyether-modified silicone, glyceryl-modified silicone, amino derivative silicone, carboxyl-modified silicone, fatty acid-modified silicone, alcohol-modified silicone, aliphatic alcohol-modified silicone, epoxy-modified silicone, fluorine-modified silicone, and alkyl-modified silicone.

Among the silicone oils, from the viewpoint of enhancing the lasting effect of repelling, at least one selected from the group consisting of dimethyl polysiloxane, dimethicone, methylphenyl polysiloxane and modified polysiloxane is preferred, at least one selected from the group consisting of dimethyl polysiloxane, dimethicone and polyether modified polysiloxane is more preferred, and dimethyl polysiloxane is further preferred.

As dimethyl polysiloxane, one or more selected from the group consisting of linear dimethyl polysiloxane and cyclic dimethyl polysiloxane can be listed. Among them, linear dimethyl polysiloxane is more preferred from the viewpoint of improving the lasting effect of repellency. As commercially available examples of linear dimethyl polysiloxane, there can be listed: KF-96 series of Shin-Etsu Chemical Co., Ltd., SH200C series of Dow Corning Toray Co., Ltd., "2-1184 Fluid", "Silsoft DML" of Momentive Performance Materials, "Element14 PDMS 5-JC", "Element14 PDMS 10-JC", "Element14 PDMS 20-JC", etc.

(b) Ester oil From the viewpoint of improving the lasting effect of the repellent, the ester oil preferably is an ester oil represented by any one of the following general formulas (1) to (3) and a dialkyl carbonate compound represented by the following general formula (4).

R ¹ -COO-R ² (1) In the general formula (1), R ¹ may be substituted with a hydroxyl group and represents a linear or branched alkyl group having 7 to 23 carbon atoms or an aromatic hydrocarbon group having 6 to 24 carbon atoms, and R ² represents a linear or branched alkyl group or alkenyl group having 1 to 22 carbon atoms. When R ¹ is an alkyl group, the carbon number is preferably 7 or more, more preferably 9 or more, from the viewpoint of improving the lasting effect of the repellent, and is preferably 21 or less, more preferably 17 or less, from the viewpoint of providing a good touch when applied to the skin. Furthermore, when ^R1 is an aromatic hydrocarbon group, the carbon number is preferably 8 or more, more preferably 10 or more, from the viewpoint of improving the lasting repellent effect, and is preferably 22 or less, more preferably 20 or less, from the viewpoint of providing a good touch when applied to the skin. From the viewpoint of providing a good touch when applied to the skin, ^R2 is preferably a linear or branched alkyl or alkenyl group having 20 or less, more preferably 18 or less carbon atoms. Furthermore, from the viewpoint of providing a good touch when applied to the skin, at least one of ^R1 or ^R2 is preferably a branched alkyl group.

Examples of the ester oil represented by the general formula (1) include 2-ethylhexanoate myristyl, 2-ethylhexanoate cetyl, 2-ethylhexanoate stearyl, isodecyl octanoate, isodecyl octanoate, isononyl isononanoate, isotridecyl isononanoate, cetyl isononanoate stearyl, octyl propyl heptanoate, methyl laurate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, palmitate, One or more of the group consisting of isocetyl stearate, 2-ethylhexyl stearate, isocetyl stearate, isotridecyl stearate, isopropyl isostearate, octyl isostearate, isocetyl isostearate, isostearyl isostearate, 2-ethylhexyl hydroxystearate, methyl oleate, oleyl oleate, isobutyl oleate, oleyl erucate, alkyl benzoate (alkyl group having 12 to 15 carbon atoms) and diethylhexyl naphthalate.

(R ³ O)-CH ₂ CH(OR ⁴ )-CH ₂ (OR ⁵ ) (2) In the general formula (2), R ³ , R ⁴ and R ⁵ are each independently a hydrogen atom or a group represented by the following general formula (2-1), and not all of them are hydrogen atoms. -CO-R ⁶ (2-1) (wherein R ⁶ represents an alkyl or alkenyl group having 7 to 23 carbon atoms, preferably 17 to 17 carbon atoms, which may be substituted with a hydroxyl group) As the ester oil represented by the general formula (2), at least one selected from the group consisting of tri(2-ethylhexanoin)glyceryl and tricaprylin can be listed. It may also be ester oils derived from plants such as jojoba oil, olive oil, sunflower seed oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheat germ oil, grape seed oil, artichoke oil, nightshade oil, macadamia nut oil, corn germ oil and pear oil.

R ⁷ O-(AO)m-COR ⁸ (3) In the general formula (3), R ⁷ represents an aromatic hydrocarbon group having 6 to 20 carbon atoms, and R ⁸ represents an alkyl or alkenyl group having 1 to 23 carbon atoms. AO represents an alkoxy group having 2 to 4 carbon atoms, and m represents an average addition molar number of 1 to 50. R ⁷ is preferably an aromatic hydrocarbon group having 6 or more carbon atoms from the viewpoint of improving the lasting repellent effect, and is preferably an aromatic hydrocarbon group having 12 or less carbon atoms, more preferably 10 or less carbon atoms, and is more preferably a benzyl group from the viewpoint of providing a good touch when applied to the skin. From the viewpoint of improving the lasting repellent effect, ^R8 is preferably an alkyl group having 7 or more carbon atoms, more preferably 11 or more carbon atoms, and from the viewpoint of providing a good touch when applied to the skin, it is preferably 21 or less carbon atoms, more preferably 15 or less carbon atoms. From the viewpoint of improving the lasting repellent effect, the AO group is preferably a propoxy group, and from the viewpoint of improving the lasting repellent effect and providing a good touch when applied to the skin, m is preferably 1 or more and 10 or less, more preferably 1 or more and 5 or less. Examples of the ester oil represented by the general formula (3) include one or more selected from the group consisting of an ester of a 3-mole adduct of propylene oxide with benzyl alcohol and myristic acid ("Crodamol STS" produced by Croda Corporation) and an ester of a 3-mole adduct of propylene oxide with benzyl alcohol and 2-ethylhexanoic acid ("Crodamol SFX" produced by Croda Corporation).

R ⁹ -O-(CH ₂ CH ₂ O)v-CO-(OCH ₂ CH ₂ )w-OR ¹⁰ (4) In the general formula (4), R ⁹ and R ¹⁰ each independently represent an alkyl or alkenyl group having 6 to 22 carbon atoms, and v and w each independently represent an average addition molar number of 0 or 1 to 50. From the viewpoint of improving the lasting repellent effect, R ⁹ and R ¹⁰ are preferably alkyl groups having 8 or more carbon atoms, and from the viewpoint of providing a good touch when applied to the skin, they are preferably 18 or less, more preferably 12 or less. From the viewpoint of providing a good touch when applied to the skin, v and w are preferably 0 or 1 to 5, more preferably 0. Examples of the dialkyl carbonate compound represented by the general formula (4) include dicaprylyl carbonate ("CETIOL CC" manufactured by Cognis).

As ester oils other than the above, esters of polycarboxylic acids and alcohols, or esters of polyols other than glycerol and fatty acids can be listed. As specific examples, one or more selected from the group consisting of diisopropyl dimer, diisopropyl adipate, diethoxyethyl succinate, 2-ethylhexyl succinate, propanediol dicaprate, neopentyl glycol dicaprate, neopentyl glycol di(2-ethylhexanoate), etc. can be listed. Among them, from the perspective of improving the lasting effect of repelling, esters of neopentyl glycol and fatty acids are preferred, and one or more selected from the group consisting of neopentyl glycol dicaprate and neopentyl glycol di(2-ethylhexanoate) are more preferred. Among the above-mentioned (b) ester oils, at least one selected from the group consisting of ester oils represented by the general formula (1) and esters of neopentyl glycol and fatty acids is preferred.

(c) Ether oil From the viewpoint of improving the lasting effect of the repellent, the ether oil is preferably a dialkyl ether compound represented by the following general formula (5) or a polyoxyalkylene alkyl ether compound represented by the following general formula (6).

R ¹¹ -OR ¹² (5) In the general formula (5), R ¹¹ and R ¹² each independently represent a linear or branched alkyl or alkenyl group having 6 to 22 carbon atoms, or an aromatic alkyl group having 6 to 24 carbon atoms. From the viewpoint of improving the lasting effect of the repellent, R ¹¹ and R ¹² are preferably alkyl groups, and the carbon number thereof is preferably 8 or more from the viewpoint of improving the lasting effect of the repellent, and is preferably 18 or less, more preferably 16 or less, and further preferably 12 or less from the viewpoint of providing a good touch when applied to the skin. Examples of the dialkyl ether compound represented by the general formula (5) include dihexyl ether, dioctyl ether ("CETIOL OE" from Cognis), dioctyl ether, and cetyl-1,3-dimethylbutyl ether ("ASE-166K" from Kao Corporation).

R ¹³ -O-(PO)r(EO)sH (6) In the general formula (6), R ¹³ represents an alkyl or alkenyl group having a carbon number of 6 to 22, PO represents a propoxy group, and EO represents an ethoxy group. r represents an average addition molar number of 0.1 to 15, and s represents an average addition molar number of 0 to 10. When s is not 0, the addition form of PO and EO may be random or block. The carbon number of R ¹³ is preferably 8 or more from the viewpoint of improving the lasting repellent effect, and is preferably 20 or less, more preferably 18 or less, and further preferably 12 or less from the viewpoint of providing a good touch when applied to the skin. The average addition molar number r is preferably 1 or more, more preferably 2 or more, and further preferably 3 or more from the viewpoint of improving the lasting repellent effect, and is preferably 13 or less, more preferably 10 or less from the viewpoint of providing a good touch when applied to the skin, and the average addition molar number s is preferably 5 or less, more preferably 1 or less, and further preferably 0 from the viewpoint of providing a good touch when applied to the skin. The polyoxyalkylene alkyl ether compound represented by the general formula (6) is preferably at least one selected from the group consisting of polyoxypropylene octyl ether, polyoxypropylene decyl ether, and polyoxypropylene lauryl ether, wherein the average addition molar number r of the propylene glycol group is 3 or more and 10 or less. Among the above-mentioned ether oils (c), the ether oils represented by the general formula (5) are preferred from the viewpoint of improving the lasting repellent effect.

(d) Hydrocarbon oil As hydrocarbon oil, there can be listed: liquid wax, liquid isostructural wax, squalane, isohexadecane, isoeicosane, hydrogenated polyisobutene, light liquid isostructural wax, heavy liquid isostructural wax, α-olefin oligomers and cyclopentane. Among them, from the viewpoint of improving the lasting effect of repellent and making the touch when applied to the skin good, it is preferred to select one or more of the group consisting of liquid wax, liquid isostructural wax and squalane.

(e) Fatty alcohol As the fatty alcohol, monovalent chain or cyclic fatty alcohols can be cited. From the viewpoint of improving the lasting effect of repellent, monovalent chain fatty alcohols are preferred. From the viewpoint of improving the lasting effect of repellent, the average carbon number of the fatty alcohol is preferably 14 or more, more preferably 18 or more, and from the viewpoint of making the touch when applied to the skin good, the carbon number of the fatty alcohol is preferably 28 or less, more preferably 24 or less, and further preferably 22 or less. The above-mentioned aliphatic alcohol may be any of linear and branched chains, and may be any of saturated and unsaturated chains. From the perspective of improving the lasting effect of the aphrodisiac and making the touch feel good when applied to the skin, branched aliphatic saturated alcohols are preferred. As linear aliphatic alcohols, oleyl alcohol and the like can be listed, and as branched aliphatic saturated alcohols, butyloctanol, butyldecanol, hexyldecanol, octyldodecanol and the like can be listed. Among them, branched aliphatic saturated alcohols are preferred from the viewpoint of improving the lasting repellent effect and providing a good touch when applied to the skin, and at least one selected from the group consisting of hexyldecanol, hexyldodecanol and octyldodecanol is preferred.

(f) Polyols As polyols, there can be mentioned: aliphatic alcohols with 2 or more carbon atoms, aromatic alcohols, sugar alcohols with 4 or more carbon atoms, etc., which may be saturated or unsaturated. From the viewpoint of making the touch when applied to the skin good, it is preferably one or more selected from the group consisting of aliphatic alcohols with 2 or more carbon atoms, aromatic alcohols, and sugar alcohols with 4 or more carbon atoms and 10 or less carbon atoms. As aliphatic alcohols with 2 or more carbon atoms in polyols, there can be mentioned: diols such as ethylene glycol, propylene glycol, 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, diethylene glycol, dipropylene glycol, and hexanediol. As the above-mentioned sugar alcohols, there can be mentioned: sorbitol, erythritol, pentaerythritol, xylitol, mannitol, etc.

Among the above-mentioned liquid oily components, from the viewpoint of improving the lasting repellent effect, preferably at least one selected from the group consisting of (a) silicone oil, (b) ester oil, (c) ether oil and (d) hydrocarbon oil, more preferably at least one selected from the group consisting of (a) silicone oil, (b) ester oil and (d) hydrocarbon oil, further preferably at least one selected from the group consisting of (a) silicone oil and (b) ester oil, further preferably (a) silicone oil. (a) Among the silicone oils, from the viewpoint of enhancing the lasting effect of repelling, preferably at least one selected from the group consisting of dimethyl polysiloxane, dimethicone, methylphenyl polysiloxane and modified polysiloxane, more preferably at least one selected from the group consisting of dimethyl polysiloxane, dimethicone and polyether modified polysiloxane, further preferably dimethyl polysiloxane, further more preferably linear dimethyl polysiloxane.

(Content of component (A)) The content of component (A) in the composition of the present invention is 13% by mass or more, preferably 20% by mass or more, and more preferably 25% by mass or more from the viewpoint of improving the lasting repellent effect, suppressing the odor originating from component (A), improving the feeling of use of the composition, and ensuring the long-term storage stability of the composition. It is 99.995% by mass or less, preferably 80% by mass or less, more preferably 50% by mass or less, further preferably 40% by mass or less, and further preferably 35% by mass or less from the viewpoint of improving the lasting repellent effect, suppressing the odor originating from component (A), improving the feeling of use of the composition, and ensuring the long-term storage stability of the composition. Therefore, the content of component (A) in the composition of the present invention is 13-99.995 mass %, preferably 13-80 mass %, more preferably 13-50 mass %, further preferably 20-40 mass %, further preferably 25-40 mass %, further preferably 25-35 mass %.

<Ingredient (B): Repellent ingredient> The composition of the present invention contains one or more repellent active ingredients selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate, ethyl 3-(acetylbutyl)aminopropionate, and 3,8-p-menthane as ingredient (B). In the following description, N,N-diethyltoluamide is referred to as "DEET", 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate is referred to as "Icaridin", ethyl 3-(acetylbutyl)aminopropionate is referred to as "IR3535", and 3,8-p-menthane is referred to as "PMD". Ingredient (B) is an existing pest repellent, and its repellent effect is well known. However, if the content is above the effective amount, specifically, if it is contained in the composition in an amount exceeding 4% by mass, an unpleasant odor originating from ingredient (B) is emitted, and skin problems such as rashes may also be caused. Therefore, in the composition of the present invention, by setting the content of ingredient (B) to a level that does not cause these problems and combining it with ingredient (A), the unpleasant odor originating from ingredient (B) can be reduced, and the repellent effect and safety can be ensured. Ingredient (B) may be contained alone or in combination with two or more. Among the components (B), from the viewpoint of improving the lasting repellent effect, it is preferred to use at least one repellent component selected from the group consisting of N,N-diethyltoluamide and 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, and from the viewpoint of ensuring the long-term storage stability of the composition, it is preferred to use at least one repellent component selected from the group consisting of N,N-diethyltoluamide and p-menthane-3,8-diol. Furthermore, PMD may be synthesized, or an essential oil obtained by refining natural eucalyptus oil (Eucalyptus citriodora) or increasing the PMD content may be used. In either case, PMD may be contained in the composition in such a manner that the content of PMD is within the specified range of the component (B) of the present invention. Examples of essential oils containing PMD include lemon oil (oil of lemon eucalyptus/OLE), Citrosynthol (Novosynth), Citrepel (CHEMIAN TECHNOLOGY), and Citriodiol (Citrefine).

(Content of component (B)) The content of component (B) in the composition of the present invention is 0.005% by mass or more, preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, further preferably 0.5% by mass or more, further preferably 0.8% by mass or more, from the viewpoint of improving the lasting repellent effect and suppressing the odor originating from component (A). Furthermore, the content of component (B) in the composition of the present invention is 3% by mass or less, preferably 2.5% by mass or less, more preferably 2.2% by mass or less, further preferably 2% by mass or less, further preferably 1.8% by mass or less, further preferably 1.5% by mass or less, from the viewpoint of suppressing unpleasant odor, allergy or skin chapped skin caused by component (B) and ensuring the long-term storage stability of the composition. Therefore, the specific range of the content of component (B) in the composition of the present invention is 0.005-3 mass%, preferably 0.01-2.5 mass%, more preferably 0.05-2.2 mass%, further preferably 0.1-2.2 mass%, further preferably 0.1-2 mass%, further preferably 0.5-2 mass%, further preferably 0.5-1.8 mass%, further preferably 0.8-1.5 mass%.

The content of the above-mentioned component (B) is not an effective amount as a pest repellent of component (B). The effective amount of the pest repellent of component (B) can refer to, for example, the minimum effective amount disclosed by the manufacturers of various repellent products. More specifically, the effective amount of DEET is 4% by mass or more, preferably 10% by mass or more, the effective amount of icaridin is 4% by mass or more, the effective amount of ethyl 3-(acetylbutyl)aminopropionate is 4% by mass or more, and the effective amount of p-menthane-3,8-diol is 4% by mass or more.

Furthermore, the composition of the present invention contains component (A) and component (B) as repellent components to deal with pest repellent, and does not contain other pest repellents in an effective amount, which is better from the perspective of preventing users from allergies or skin chapped skin. Even if the composition of the present invention does not contain pest repellents other than component (A) and component (B) in an effective amount, it also has a lasting repellent effect. In other words, if the composition of the present invention contains pest repellents other than component (A) and component (B) in an amount that does not reach the lower limit of the effective amount, the pests will not stay on the spot even if they land, which means that the stay inhibition effect of the present invention is manifested. That is, the composition of the present invention may substantially not contain existing pest repellents other than component (A) and component (B).

Here, the term "not containing pest repellents other than component (A) and component (B) in an effective amount" generally means that the content of pest repellents other than component (A) and component (B) in the composition of the present invention is preferably 15% by mass or less, more preferably 10% by mass or less, further preferably 5% by mass or less, further preferably 4% by mass or less, further preferably 3% by mass or less, further preferably 1% by mass or less. The effective amount of existing pest repellents other than component (B) can also refer to the minimum effective amount disclosed by the manufacturers of various repellent products. For example, among existing pest repellents other than component (B), the effective amount of citronella oil is 10% by mass or more. Therefore, in the present invention, setting the content of citronella oil to 5% by mass or less is one of the preferred aspects of the present invention, and even more preferably, it is 1% by mass or less.

In addition, the effective amount of existing pest repellents can also be measured by the repellent rating test described below. (Repellent rating test) 100 mated female mosquitoes (Aedes albopictus) are placed in a plastic cage (30×30×30 cm: BugDorm-1 cage) surrounded by a mesh. Put the arm into a Qualatex super long glove (KUALATEC Super Long Gloves) (50 cm) (ASONE Co., Ltd., product code (Catalog number): 3-6432-02) with a rectangular cut of 5 cm in length and 4 cm in width on the elbow side about 15 cm from the wrist. Without applying any application to the exposed part from the incision, extend your arm into the cage and confirm that mosquitoes land on 2 places on the exposed skin within 2 minutes and stay for more than 1 second. If they do not stay for more than 1 second, prepare new mosquitoes. In the following, staying for more than 1 second is simply referred to as staying. The test of the evaluation sample of the solution as a pest repellent is carried out after adjusting the concentration using ethanol in a way that the evaluation sample can be applied to the exposed skin (5 cm×4 cm) at 2 mg/ ^cm2 . Using PIPETMAN, drop the solution with adjusted concentration onto the exposed skin and apply it to cover the entire exposed skin (required solution volume: 40-50 μl). After leaving it alone for 3 minutes, start the test. The test is conducted by inserting the arm coated with the evaluation sample into the cage for 2 minutes and counting the number of times it stays. The test is considered to be over when there are 2 total stops. Before the end of the test, the arm is inserted into the cage for 2 minutes every 30 minutes. When there is a second stop at the 30th minute, the duration of the repellent effect is judged to be 0 minutes. When there is a second stop at the 60th minute, the duration of the repellent effect is judged to be 30 minutes. The test is conducted by 3 subjects, and the average duration of the repellent effect is calculated. In this test, the concentration of the pest repellent that shows an average duration of the repellent effect of more than 2 hours can be set as the effective concentration (effective amount) of the pest repellent. The composition of the present invention has a lasting repellent effect even if it does not contain an effective amount of a pest repellent other than component (A) and component (B). Therefore, from the viewpoint of suppressing the unpleasant odor or strong odor of the pest repellent other than component (B) and preventing skin problems, it is better to substantially not contain a pest repellent other than component (A) and component (B). In the composition of the present invention, the content of the pest repellent other than component (A) and component (B) is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, further preferably 0.01% by mass or less, further preferably substantially 0% by mass.

Existing pest repellents other than component (A) and component (B) include: dimethyl phthalate, 2-ethyl-1,3-hexanediol, p-menthane-3,8-diol, carane-3,4-diol, di-n-butyl succinate, hydroxyanisole, rotenone, citronellol, eucalyptol, α-pinene, geraniol, citronellal, camphor, linalool, 2-undecanone and other known pest repellent compounds, and repellent essential oils such as citronella oil, lemongrass oil, eucalyptus oil, peppermint oil, catmint oil, etc. The so-called "repellent essential oil" refers to an essential oil obtained by extracting, distilling or pressing components contained in plants and having a pest repellent effect.

In the composition of the present invention, the mass ratio [(A)/(B)] of component (A) to component (B) is preferably 7 or more, more preferably 13 or more, and further preferably 25 or more from the viewpoint of suppressing unpleasant odor, and is preferably 3000 or less, more preferably 300 or less, further preferably 100 or less, and further preferably 50 or less from the viewpoint of improving the lasting repellent effect. Therefore, the mass ratio [(A)/(B)] of component (A) to component (B) is preferably 7 to 3000, more preferably 7 to 300, further preferably 13 to 300, further preferably 13 to 100, further preferably 13 to 50, and further preferably 25 to 50.

<Ingredient (C): Water> From the perspective of improving the lasting effect of repellent and making a composition with good feeling of use, the composition of the present invention preferably contains water as ingredient (C). Regarding the content of ingredient (C) in the composition, from the perspective of improving the lasting effect of repellent and making a composition with good feeling of use, it is preferably 5% by mass or more, more preferably 10% by mass or more, further preferably 35% by mass or more, further preferably 50% by mass or more. Furthermore, from the perspective of improving the lasting effect of repellent, it is preferably 86.995% by mass or less, more preferably 85% by mass or less, further preferably 80% by mass or less, further preferably 75% by mass or less. Therefore, the content of component (C) in the composition is preferably 5-86.995 mass %, more preferably 5-85 mass %, further preferably 10-80 mass %, further preferably 35-75 mass %, further preferably 50-75 mass %.

The present invention can be applied to various forms of compositions, for example, non-aqueous compositions that do not contain water, water-in-oil compositions, oil-in-water compositions, etc. From the perspective of suppressing the odor originating from component (A), it is preferred to prepare an oil-in-water composition. Furthermore, when preparing an oil-in-water composition, the content of component (C) in the composition is preferably 35% by mass or more, more preferably 40% by mass or more, and further preferably 45% by mass or more from the perspective of ensuring the long-term storage stability of the composition. Furthermore, from the perspective of improving the lasting effect of repelling, it is preferably 86.995% by mass or less, preferably 80% by mass or less, and more preferably 75% by mass or less. In addition, from the perspective of improving the lasting effect of repelling, it is preferred to prepare a water-in-oil type composition. Furthermore, when preparing a water-in-oil type composition, the content of component (C) in the composition is 5% by mass or more, preferably 10% by mass or more, and more preferably 15% by mass or more, from the perspective of making the touch when applied to the skin good. In addition, from the perspective of improving the lasting effect of repelling, it is 40% by mass or less, preferably 30% by mass or less, and more preferably 25% by mass or less.

When the composition of the present invention contains component (C), the mass ratio [(A)/(C)] of component (A) to component (C) is preferably 0.15 or more, more preferably 0.25 or more, and further preferably 0.35 or more from the viewpoint of improving the lasting repellent effect, and is preferably 1.6 or less, more preferably 1.0 or less, further preferably 0.8 or less, and further preferably 0.6 or less from the viewpoint of ensuring the long-term storage stability of the composition. Therefore, the mass ratio [(A)/(C)] of component (A) to component (C) is preferably 0.15 to 1.6, more preferably 0.25 to 1.0, further preferably 0.35 to 0.8, and further preferably 0.35 to 0.6.

<Ingredient (D): Thickener> The composition of the present invention may further contain a thickener as ingredient (D). From the perspective of improving the lasting effect of the repellent by adjusting the liquid properties after application to the skin, ensuring excellent application properties on the skin by making each component well dispersed or dissolved, and ensuring the long-term storage stability of the composition, the thickener is preferably one with appropriate emulsification ability (i.e., interfacial activity). In the present invention, an agent having emulsification ability and thickening effect is set as the thickener. Component (D) includes water-soluble cationic polymers, anionic polymers, nonionic polymers, and amphoteric polymers or dipolar polymers. It is preferred that the component (D) contains at least one selected from the group consisting of anionic polymers and nonionic polymers, and more preferably contains anionic polymers and nonionic polymers.

Specifically, cationic polymers include hydroxyethyl cellulose containing O-[2-hydroxy-3-(trimethylammonium)propyl] chloride (polyquaternary ammonium salt-10), vinyl pyrrolidone-methacrylate dimethylaminomethylethyl ester copolymer diethyl sulfate salt (polyquaternary ammonium salt-11), methylvinyl imidazolium chloride-vinyl pyrrolidone copolymer, and the like.

As anionic polymers, specifically, carboxyvinyl polymer, carboxymethyl cellulose, carrageenan, santhemum gum, polystyrene sulfonate, agar, gum, karaya gum, pectin, alginate, acrylic acid-alkyl methacrylate copolymer, (acryloyldimethyltaurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymer, (sodium acrylate/sodium acryloyldimethyltaurate) copolymer, polyacrylamide, (acryloyldimethyltaurate/vinylpyrrolidone) copolymer , (acrylates/alkyl acrylate (C10-C30) ester) crosslinked polymer, (ammonium acryloyldimethyltaurate/behenyl methacrylate polyether-25 ester) crosslinked polymer, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer, (acrylamide/ammonium acrylate) copolymer, (sodium acrylate/acryloyldimethyltaurate/dimethylacrylamide) crosslinked polymer, polyacrylate-13, polyacrylate crosslinked polymer-6, alkali metal salt of poly(acrylic acid), hyaluronic acid or its alkali metal salt. From the perspective of ensuring excellent application properties on the skin by dispersing or dissolving each component well, and ensuring the long-term storage stability of the composition, the anionic polymer is preferably one or more selected from the group consisting of (ammonium acryloyldimethyltaurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymer and (ammonium acryloyldimethyltaurate/behenyl methacrylate-25) crosslinked polymer.

As non-ionic polymers, specifically, there can be mentioned: cellulose ethers (hydroxybutyl methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethyl hydroxyethyl cellulose, hydroxyethyl cellulose, etc.), propylene glycol alginate, poly(ethylene oxide), polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, locust bean gum, linear starch, hydroxyethyl linear starch, starch and starch derivatives and mixtures thereof. From the perspective of improving the repellent effect by adjusting the liquid properties after applying to the skin, cellulose ethers are preferred.

As amphoteric polymers or bipolar polymers, specifically, they include: octyl acrylamide/acrylate/butylaminoethyl methacrylate copolymer, polyquaternary ammonium salt-47, polyquaternary ammonium salt-43, etc.

Component (D) may be used alone or in combination of two or more. From the viewpoint of improving the duration of the pest repellent effect by adjusting the liquid properties after application to the skin, ensuring excellent application properties on the skin by making each component well dispersed or dissolved, and ensuring the long-term storage stability of the composition, component (D) is preferably one or more selected from the group consisting of anionic polymers and nonionic polymers, preferably selected from carboxyvinyl polymers, acrylic acid-alkyl methacrylate copolymers, (ammonium acryloyldimethyltaurate/ methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymers, (sodium acrylate/sodium acryloyldimethyltaurate) copolymers, One or more selected from the group consisting of (acrylates/alkyl (C10-C30) acrylates) crosslinked polymers, (ammonium acryloyldimethyltaurate/behenyl methacrylate-25 ester) crosslinked polymers, and cellulose ethers, and more preferably one or more selected from the group consisting of (ammonium acryloyldimethyltaurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymers, (sodium acrylate/sodium acryloyldimethyltaurate) copolymers, (acrylates/alkyl (C10-C30) esters) crosslinked polymers, and (ammonium acryloyldimethyltaurate/behenyl methacrylate-25 ester) crosslinked polymers.

When containing anionic polymers and nonionic polymers as component (D), it is preferred to use at least one anionic polymer selected from the group consisting of (ammonium acryloyldimethyltaurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymer and (ammonium acryloyldimethyltaurate/behenyl methacrylate-25 ester) crosslinked polymer together with cellulose ether as a nonionic polymer from the viewpoint of enhancing the lasting effect of repelling, making each component well dispersed or dissolved to ensure excellent application properties on the skin, and ensuring the long-term storage stability of the composition of the present invention.

When anionic polymer and nonionic polymer are used together as component (D), the mass ratio [anionic polymer/nonionic polymer] is preferably 10/90~90/10, more preferably 20/80~80/20, and further preferably 35/65~65/35 from the viewpoint of improving the lasting effect of repelling, ensuring excellent application properties on the skin by making each component well dispersed or dissolved, and ensuring the long-term storage stability of the composition.

As commercially available products of the thickener, for example, "CARBOPOL 980", "CARBOPOL 981", "CARBOPOL 1342", "CARBOPOL ETD2020", "PEMULEN TR-1", "PEMULEN TR-2" from Lubrizol Advanced Materials, "Aculyn 22" from Dow Chemical, "Aristoflex AVC", "Aristoflex HMB", "Aristoflex Velvet" manufactured by Clariant Iberica Production S.A., etc. can be used. Furthermore, the thickener can also be formulated into a dispersion obtained by dispersing in a dispersion medium.

The content of component (D) in the composition of the present invention is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and further preferably 0.1% by mass or more, from the viewpoint of improving the lasting effect of repelling, making each component well dispersed or dissolved to ensure excellent application properties on the skin, and ensuring the long-term storage stability of the composition. From the same viewpoint, it is preferably 5% by mass or less, more preferably 3% by mass or less, and further preferably 1% by mass or less. Furthermore, when the composition of the present invention contains a thickening agent having interfacial activity, the content of other interfacial agents in the composition is preferably 1.5% by mass or less, and further preferably 1% by mass or less.

<Other ingredients> The composition of the present invention may contain ingredients other than the above as long as the effect of the present invention is not impaired, such as surfactants, preservatives, colorants, moisturizers, fragrances, pH adjusters, etc. In addition, it may contain vitamins, blood flow promoters, deoxidizers, anti-inflammatory agents, whitening agents, bactericides, and other medicinal or physiologically active ingredients. Furthermore, fragrances may be used as bactericides, etc. for other purposes.

The composition of the present invention can be prepared by conventional methods, for example, by mixing components (A), (B) and other components as required, and stirring them using a known device.

There is no particular limitation on the pests that the composition of the present invention is intended to repel, and it is more effective against flying pests. The so-called "flying pests" refer to pests that fly close to humans and other animals and suck blood from their skin, or pests that spread pathogenic bacteria while flying even if they do not suck blood, or pests whose flying behavior itself brings discomfort to humans, etc. Specific examples of flying pests include Culex pipiens pallens, Culex tritaeniorhynchus, Culex pipiens molestus, Culex quinquefasciatus, Aedes aegypti, Aedes albopictus, Anopheles sinensis, Aedes togoi, Anopheles gambiae, Anopheles stephensi, Chironomus yoshimatsui, Tokunagayusurika akamusi, Twinnia japonensis Rubtsov, Prosimulium yezoense), Simulium aokii Takahasi, etc.; flies such as house flies (Musca domestica), rot flies (Muscina stabulans), summer toilet flies (Fannia canicularis), beautiful flies (Calliphoridae), flesh flies (Sarcophagidae), gray ground flies (Delia platura), onion flies (Delia antiqua), fruit flies (Tephritidae), fruit flies (Drosophilidae), butterfly flies (Psychodidae), tongue flies (Glossinidae), stinging flies (Stomoxys calcitrans), etc.; flies such as ring flies, gadflies, blind flies, and horse flies; Japanese midges (Leptoconops nipponensis Tokunaga), slow fleas (Leptopsylla segnis), Culicoides arakawae, etc.; yellow sparrow bee (Vespa simillima xanthoptera), dark yellow long-legged bee (Polistes jokahamae), honey bee (Apidae), etc. The composition of the present invention has an excellent and lasting effect on the above-mentioned mosquitoes. Among the above-mentioned mosquitoes, the composition has an excellent and lasting effect on Culex pipiens pallens, Culex tritaeniorhynchus, Culex subterraneanus, Culex quinquefasciatus, Aedes aegypti, and Aedes albopictus.

[Pest repellent method, pest retention inhibition method] The pest repellent method of the present invention is carried out by applying the pest repellent composition of the present invention to the surface of human skin. In addition, the pest retention inhibition method of the present invention is to prevent pests from staying on human skin by allowing the pest retention inhibition composition of the present invention to attach to the limbs of pests, especially flying pests. Hereinafter, these methods are also collectively referred to as "the method of the present invention".

Here, "applying on the skin surface" not only means applying the composition directly on the skin surface with hands, etc., but also includes attaching the composition to the skin surface by spraying, etc. From the viewpoint of improving the lasting effect of repellent, the amount of the composition applied on the skin surface is preferably 0.1 mg or more per 1 ^cm2 , more preferably 0.2 mg or more, and further preferably 0.25 mg or more. In addition, from the viewpoint of suppressing stickiness and economy, the upper limit of the amount applied is preferably 10 mg or less per 1 ^cm2 , more preferably 8 mg or less, and further preferably 5 mg or less.

From the perspective of providing a mosquito repellent composition that has excellent and lasting mosquito repellent effect, is safe, suppresses unpleasant odors from repellent ingredients, and has excellent feel during use, the composition of the present invention is preferably a water-in-oil type mosquito repellent composition or mosquito residence inhibition composition containing the following components (A) to (C), and the content of the pest repellent other than components (A) and (B) is 15% by mass or less. (A) Non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol, with a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa・s or less at 23°C measured by a B-type rotational viscometer: 13% to 50% by mass (B) Non-volatile components selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% to 3% by mass (C) Water: 35% to 86.995% by mass

From the perspective of providing a mosquito repellent composition that has an excellent and lasting mosquito repellent effect, is safe, and has an excellent feel when used due to the suppression of unpleasant odors from the repellent ingredients, the composition of the present invention is preferably a water-in-oil type mosquito repellent composition or mosquito residence inhibition composition containing the following components (A) to (C), wherein the mass ratio [(A)/(C)] of component (A) to component (C) is 0.15 to 1.6, and the content of the pest repellent other than components (A) and (B) is 15% by mass or less. (A) Non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol, with a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa・s or less at 23°C measured by a B-type rotational viscometer: 13% to 50% by mass (B) Non-volatile components selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% to 3% by mass (C) Water: 35% to 86.995% by mass

From the perspective of providing a mosquito repellent composition that has an excellent and lasting mosquito repellent effect, is safe, and has an excellent feel when used due to the suppression of unpleasant odors from repellent ingredients, the composition of the present invention is preferably a water-in-oil type mosquito repellent composition or mosquito residence inhibition composition containing the following components (A) to (C), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 to 3000, the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, and the content of pest repellents other than components (A) and (B) is 15% by mass or less. (A) Non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol, with a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa・s or less at 23°C measured by a B-type rotational viscometer: 13% to 50% by mass (B) Non-volatile components selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% to 3% by mass (C) Water: 35% to 86.995% by mass

From the perspective of providing a mosquito repellent composition that has excellent and lasting mosquito repellent effect, is safe, suppresses unpleasant odors originating from repellent ingredients, and has excellent feel during use, the composition of the present invention is preferably a water-in-oil type mosquito repellent composition or mosquito residence inhibition composition containing the following components (A) to (D), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 to 3000, the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, and the content of pest repellents other than components (A) and (B) is 15% by mass or less. (A) One or more non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil and hydrocarbon oil, with a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa・s or less at 23°C measured by a B-type rotational viscometer: 13% to 50% (B) One or more repellent components selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinylcarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% to 3% (C) Water: 35% to 86.995% (D) Thickener: 0.05% to 5%

The pest repellent method of the present invention is to prevent pests such as mosquitoes from staying on the object coated or attached with the composition of the present invention even if the pests such as mosquitoes land on the object, and specifically, it has the following staying inhibition effect: after the pests such as mosquitoes land on the skin of humans and animals, they are not allowed to stay on the skin surface of the animal for a period of time that can be inserted with a needle, specifically, for example, more than 1 second. This effect is based on the previously unseen pest repellent principle, and is relatively safe, without side effects such as skin chapped.

In relation to the above-mentioned embodiments, the present invention further discloses the following embodiments. ＜1＞ A water-based oil-type pest repellent composition or pest residence inhibiting composition, comprising the following components (A) and (B), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 or more and 3000 or less, (A) at least one non-volatile liquid oil component selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, fatty alcohol and polyol having a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa·s or less at 23°C measured by a B-type rotational viscometer: 13% or more and 99.995% or less; (B) One or more ingredients to be avoided selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005 mass % to 3 mass %. ＜2＞ The composition as described in ＜1＞, wherein the mass ratio [(A)/(B)] of component (A) to component (B) is 13 or more, preferably 25 or more, and preferably 300 or less, more preferably 100 or less, and further preferably 50 or less. <3> A composition as described in any one of <1> to <3>, wherein the content of the existing pest repellent other than component (B) is 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, further preferably 4% by mass or less, further preferably 3% by mass or less, further preferably 1% by mass or less. <4> A composition as described in <3>, wherein the existing pest repellent other than component (B) is citronella oil. <5> A composition as described in any one of <1> to <4>, wherein the surface tension of component (A) at 25°C is 15 mN/m or more, preferably 17 mN/m or more, and 30 mN/m or less, preferably 28 mN/m or less, more preferably 25 mN/m or less, further preferably 23 mN/m or less, further preferably 21 mN/m or less. <6> A composition as described in any one of <1> to <5>, wherein the viscosity of component (A) at 23°C measured by a B-type rotational viscometer is 1 mPa·s or more and 300 mPa·s or less, preferably 210 mPa·s or less, more preferably 100 mPa·s or less, further preferably 60 mPa·s or less, further preferably 40 mPa·s or less, further preferably 30 mPa·s or less. <7> A composition as described in any one of <1> to <6>, wherein component (A) is one or more selected from the group consisting of silicone oil, ester oil, ether oil and hydrocarbon oil, preferably one or more selected from the group consisting of silicone oil, ester oil and hydrocarbon oil, more preferably one or more selected from the group consisting of silicone oil and ester oil, and more preferably silicone oil. <8> A composition as described in any one of <1> to <7>, wherein the content of component (A) is 20% by mass or more, preferably 25% by mass or more, and 80% by mass or less, preferably 50% by mass or less, more preferably 40% by mass or less, and more preferably 35% by mass or less. <9> A composition as described in any one of <1> to <8>, wherein component (B) is one or more selected from the group consisting of N,N-diethyltoluamide and 2-(2-hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester. <10> A composition as described in any one of <1> to <9>, wherein the content of component (B) is 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, further preferably 0.5% by mass or more, further preferably 0.8% by mass or more, and is 2.5% by mass or less, preferably 2.2% by mass or less, more preferably 2% by mass or less, further preferably 1.8% by mass or less, further preferably 1.5% by mass or less.

<11> A composition as described in any one of <1> to <10>, which contains water as component (C). <12> A composition as described in <11>, wherein the content of component (C) is 5% by mass or more, preferably 10% by mass or more, more preferably 35% by mass or more, and further preferably 50% by mass or more, and is 86.995% by mass or less, preferably 85% by mass or less, more preferably 80% by mass or less, and further preferably 75% by mass or less. <13> The composition described in <11> or <12> is an oil-in-water composition, and the content of component (C) in the composition is preferably 35% by mass or more, more preferably 40% by mass or more, and more preferably 45% by mass or more, and preferably 86.995% by mass or less, preferably 80% by mass or less, and more preferably 75% by mass or less. <14> The composition described in <11> or <12> is an oil-in-water composition, and the content of component (C) in the composition is preferably 5% by mass or more, more preferably 10% by mass or more, and more preferably 15% by mass or more, and preferably 40% by mass or less, more preferably 30% by mass or less, and more preferably 25% by mass or less. <15> A composition as described in any one of <11> to <14>, wherein the mass ratio [(A)/(C)] of component (A) to component (C) is 0.15 or more, preferably 0.25 or more, more preferably 0.35 or more, and 1.6 or less, preferably 1.0 or less, more preferably 0.8 or less, and further preferably 0.6 or less. <16> A composition as described in any one of <1> to <15>, further comprising a thickener as component (D) in an amount of preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, and preferably 5% by mass or less, more preferably 3% by mass or less, and further preferably 1% by mass or less. <17> The composition described in <16> contains as component (D) at least one selected from the group consisting of water-soluble cationic polymers, anionic polymers, nonionic polymers, and amphoteric polymers or dipolar polymers, preferably at least one selected from the group consisting of anionic polymers and nonionic polymers, and more preferably anionic polymers and nonionic polymers. <18> The composition as described in <17> contains a compound selected from carboxyvinyl polymer, carboxymethyl cellulose, carrageenan, safflower gum, polystyrene sulfonate, agar, gum gandi, gum karaya, pectin, alginate, acrylic acid-alkyl methacrylate copolymer, (acryldimethyltaurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymer, (sodium acrylate/sodium acryldimethyltaurate) copolymer, polyacrylamide, (acryldimethyltaurate/vinylpyrrolidone) copolymer, (acrylate/alkyl acrylate (C10-C30) ester) crosslinked polymer, (acryldimethyltaurate/methacrylate behenyl alcohol polyether- 25 ester) crosslinked polymer, (hydroxyethyl acrylate/sodium acryloyldimethyl taurate) copolymer, (acrylamide/ammonium acrylate) copolymer, (sodium acrylate/acryloyldimethyl taurate/dimethylacrylamide) crosslinked polymer, polyacrylate-13, polyacrylate crosslinked polymer-6, poly(acrylic acid) alkali metal salt, hyaluronic acid or its alkali metal salt as anionic polymer, preferably one or more selected from the group consisting of (ammonium acryloyldimethyl taurate/methacrylic acid/ammonium methacrylate/dimethylacrylamide) copolymer and (ammonium acryloyldimethyl taurate/behenyl methacrylate polyether-25 ester) crosslinked polymer.

<19>

The composition described in <17> or <18> contains one or more selected from the group consisting of cellulose ether (selected from the group consisting of hydroxybutyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, ethyl hydroxyethyl cellulose and hydroxyethyl cellulose), propylene glycol alginate, poly(ethylene oxide), polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, locust bean gum, linear starch, hydroxyethyl linear starch, starch and starch derivatives and mixtures thereof as non-ionic polymers, preferably containing cellulose ether.

<20>

The composition described in any one of <16> to <19> preferably contains one or more anionic polymers selected from the group consisting of (ammonium acryloyl dimethyl taurate/methacrylic acid/ammonium methacrylate/dimethyl acrylamide) copolymer and ammonium acryloyl dimethyl taurate/behenyl methacrylate-25 crosslinked polymer and cellulose ether as a non-ionic polymer as component (D). <21> A composition as described in any one of <16> to <20>, which contains anionic polymer and nonionic polymer as component (D), and the mass ratio [anionic polymer/nonionic polymer] is preferably 10/90 to 90/10, more preferably 20/80 to 80/20, and further preferably 35/65 to 65/35. <22> A water-oil type mosquito repellent composition or mosquito stay inhibiting composition, which contains the following components (A) to (C), the content of pest repellent other than component (A) and component (B) is 15% by mass or less, (A) has a surface tension of 40 mN/m or less at 25°C, and a viscosity of 400 at 23°C measured by a B-type rotational viscometer. mPa・s or less non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 50 mass% or less; (B) 1 or more taboo components selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.01 mass% or more and 3 mass% or less; (C) Water: 35 mass% or more and 86.995 mass% or less. <23> A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (C), wherein the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 or more and 1.6 or less, and the content of pest repellent other than component (A) and component (B) is 15% by mass or less, and the surface tension of (A) at 25°C is 40 mN/m or less, and the viscosity at 23°C measured by a B-type rotational viscometer is 400 mPa・s or less non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 50 mass% or less; (B) One or more taboo ingredients selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.005 mass% or more and 3 mass% or less; (C) Water: 35 mass% or more and 86.995 mass% or less. <24> A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (C), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 to 3000, the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, the content of pest repellent other than components (A) and (B) is 15% by mass or less, (A) has a surface tension of 40 mN/m or less at 25°C, and a viscosity of 400 at 23°C measured by a B-type rotational viscometer. mPa・s or less non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol: 13 mass% or more and 50 mass% or less; (B) One or more taboo ingredients selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinylcarboxylic acid 1-methylpropyl ester, 3-(acetylbutyl)aminopropionic acid ethyl ester and p-menthane-3,8-diol: 0.005 mass% or more and 3 mass% or less; (C) Water: 35 mass% or more and 86.995 mass% or less. <25> A water-based oil-based mosquito repellent composition or mosquito residence inhibiting composition, comprising the following components (A) to (D), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 to 3000, the mass ratio of component (A) to component (C) [(A)/(C)] is 0.15 to 1.6, the content of pest repellent other than components (A) and (B) is 15% by mass or less, (A) has a surface tension of 40 mN/m or less at 25°C, and a viscosity of 400 at 23°C measured by a B-type rotational viscometer. mPa・s or less, one or more non-volatile liquid oily components selected from the group consisting of silicone oil, ester oil and hydrocarbon oil: 13% to 50% by mass; (B) One or more repellent components selected from the group consisting of N,N-diethyltoluamide, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate, ethyl 3-(acetylbutyl)aminopropionate and p-menthane-3,8-diol: 0.005% to 3% by mass; (C) Water: 35% to 86.995% by mass; (D) Thickener: 0.05% to 5% by mass. <26> The composition as described in <25>, wherein component (D) contains one or more anionic polymers selected from the group consisting of (ammonium acryloyl dimethyl taurate/methacrylic acid/ammonium methacrylate/dimethyl acrylamide) copolymer and ammonium acryloyl dimethyl taurate/behenyl methacrylate-25 crosslinked polymer and cellulose ether as a non-ionic polymer, and the mass ratio [anionic polymer/non-ionic polymer] is 10/90 to 90/10. <27> A method for repelling pests, which comprises applying the composition as described in any one of <1> to <26> on the surface of human skin. <28> A method for inhibiting the residence of pests, which prevents the pests from residing on human skin by allowing the composition described in any one of <1> to <26> to attach to the body of the pest. [Example]

The present invention is described below by way of examples, but the present invention is not limited to the scope of the examples. Furthermore, in the present examples, various measurements and evaluations are performed by the following methods.

(Surface tension of liquid oily components) The surface tension of liquid oily components is measured using the automatic surface tensiometer "Tensiometer K100" (KRUSS) by the Wilhelmy method using a platinum plate at 25°C.

(Viscosity of liquid oily components) As a B-type rotational viscometer in accordance with JIS K7117-1:1999, "Viscometer TVB-10" of Toki Industry Co., Ltd. was used. Since the viscosity values of the measured components vary greatly among the samples, it is difficult to accurately measure all of them under one measurement condition. Therefore, two types of rotors were used for measurement. First, the viscosity was measured at 12 rpm using rotor M2 at 23°C. At this time, for components with a viscosity of more than 2500 mPa・s, the viscosity value was obtained by measuring again at 6 rpm. On the other hand, for components with a viscosity of 20 mPa・s or less, the L-connector (Adapter) used as a rotor for low viscosity was used to measure again at 23°C with the rotation speed set to 30 rpm to obtain the viscosity value.

(Evaluation of the sustained effect of repelling pests) (I) Preparation of Aedes albopictus Aedes albopictus eggs provided by Sumitomo Techno Service Co., Ltd. were raised in cages at 27°C and 60% relative humidity (RH) to grow into adults. Put about 1 cm of water in a transparent plastic dish, put a filter paper with the purchased eggs, and let the eggs hatch into pupae. After that, feed the hatched pupae with tropical fish bait (TetraMin) as larval bait every day. After 1 week, use a dropper to collect the pupae, transfer them to a 20 mL plastic cup, and transfer them to a cage covered with a net. For pupae, 10% sucrose as adult food was placed in a 25 mL plastic tube for feeding. After emergence, male and female mosquitoes were raised in the same cage for 5 days before mating. After 5 days of breeding, adult mosquitoes were collected using a fluke tube, and after 5 minutes of anesthesia on ice, male and female mosquitoes were visually distinguished, and only female mosquitoes were collected for evaluation.

(II) Determination of the duration of the repellent effect About 100 female Aedes albopictus mosquitoes were placed in a plastic cage (30×30×30 cm) and tested at 27°C and 60% relative humidity (RH). A hole of 4×5 cm was made on the forearm of a rubber glove the size of the subject's arm, and the composition of each example was evenly applied at 2 mg/cm ^2. Thereafter, air was blown into the plastic cage for 5 seconds to revive the Aedes albopictus mosquitoes. The test was conducted in the following manner: the forearm just after the composition was applied was extended into the plastic cage, thereby exposing the Aedes albopictus mosquitoes for 2 minutes, and the number of mosquitoes that stayed was counted. The experiment was considered to be over when there were two total stays. Two-minute exposures were performed every 30 minutes until the end of the experiment. If there was a second stay during the 30th minute of exposure, the duration of the repellent effect was determined to be 0 minutes. If there was a second stay during the 60th minute of exposure, the duration of the repellent effect was determined to be 30 minutes. The experiment was conducted by three subjects, and the average duration of the repellent effect was calculated.

(Evaluation of odor intensity) The test product was applied to a 4.5×4.5 cm area on the inner side of a person's forearm in a concentration of 2 mg/ ^cm2 . Immediately thereafter, 3 evaluators conducted a sensory evaluation to determine the intensity. The odor intensity was evaluated in 6 evaluation stages (5: strong odor, 4: relatively strong odor, 3: easily perceptible odor, 2: a weak odor with a certain odor, 1: barely perceptible odor, 0: no odor), and the average of the evaluations of the 3 evaluators was taken as the odor intensity. The odor intensity suitable for skin application is classified as follows. The smaller the value, the better the composition. A: 2.5 or less B: more than 2.5 and less than 3.5 C: more than 3.5

(Evaluation of long-term storage stability) Put 80 mL of the composition of each example in a 100 mL glass bottle and seal it. After storing it at 50°C for 1 month, visually check whether there is oil phase separation in the composition and express it according to the following standards. A: No change. B: The oil phase is unified, but a small amount of self-emulsified material can be seen oozing out to the surface. C: Oil phase separation can be seen.

Examples 1 to 38, Comparative Examples 1 to 11 (Preparation and Evaluation of Compositions) The components shown in Table 1 were prepared according to the proportions shown in Tables 2 to 8, and the stirring part of T.K.ROBOMIX (Special Machinery Chemical Industry Co., Ltd.) was replaced with T.K.Homo-Mixer MARKII2.5 and stirred at 8,000 rpm for 2 minutes. After this step, the water-oil type composition of each example was obtained. The notations (A) to (D) listed in the table correspond to the components (A) to (D) in this manual, respectively, and the notation (a) corresponds to the liquid oil component outside the scope of component (A) in this manual. In addition, the proportions listed in Tables 2 to 8 are the effective ingredient amounts (mass %) of each component. The obtained composition was used to perform various evaluations by the above-mentioned methods. The results are shown in Tables 2 to 8.

[Table 1] Table 1 Product name Ingredient Name Manufacturer Name 25℃ Surface tension [mN/m] 23℃ Viscosity [mPa・s] (A1) Silicone KF-96Α-6cs Dimethicone Shin-Etsu Chemical Co., Ltd. 19.0 5 (A2) Silicone KF-96Α-10cs Dimethicone Shin-Etsu Chemical Co., Ltd. 21.0 10 (A3) Silicone KF-96Α-50cs Dimethicone Shin-Etsu Chemical Co., Ltd. 21.0 60 (A4) Silicone KF-96Α-200cs Dimethicone Shin-Etsu Chemical Co., Ltd. 21.0 210 (A5) EXCEPARL IPM Isopropyl myristate Kao Corporation 28.0 5 (A6) NIKKOL Squalane Squalane Nippon Surfactant Industries Co., Ltd. 30.0 42 (A7) ASE-166K Cetyl-1,3-dimethylbutyl ether Kao Corporation 28.0 7 (A8) Polypropylene glycol 1,3-butylene glycol Polypropylene glycol/1,3-butylene glycol (mixture of 3/7 by mass ratio) Fuji Film Wako Pure Chemical Industries, Ltd. 34.0 160 (a1) Silicone KF-96-500cs Dimethicone Shin-Etsu Chemical Co., Ltd. 21.0 560 (a2) ZEMEA PROPANEDIOL Propylene glycol DuPont Tate & Lyle Bio Products, LLC 48.0 53 (a3) Glycerine glycerin Fuji Film Wako Pure Chemical Industries, Ltd. 65.0 950 (a4) Silicone KF-96-5000cs Dimethicone Shin-Etsu Chemical Co., Ltd. 21.0 4500 (B1) DEET N,N-Diethyltoluamide Tokyo Chemical Industry Co., Ltd. - - (B2) Ekaridin 2-(2-Hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester Combi-Blocks - - (B3) IR3535 Ethyl 3-(acetylbutyl)aminopropionate Fluorochem Ltd. - - (B4) p-Menthane-3,8-diol p-Menthane-3,8-diol Tronto Research Chemicals - - (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer Clariant Iberica Production SA - - (D2) PEMULEN TR-1 (Acrylates/Alkyl Acrylate (C10-C30) Ester) Crosslinked Polymer Lubrizol Advanced Materials, Inc. - - (D3) PEMULEN TR-2 (Acrylates/Alkyl Acrylate (C10-C30) Ester) Crosslinked Polymer Lubrizol Advanced Materials, Inc. - -

[Table 2] Table 2 Embodiment Comparison Example 1 2 3 4 1 (A1) Silicone KF-96Α-6cs Dimethicone 30.00 30.00 30.00 30.00 30.00 (B1) DEET N,N-Diethyltoluamide 2.00 - - - - (B2) Ekaridin 2-(2-Hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester - 2.00 - - - (B3) IR3535 Ethyl 3-(acetylbutyl)aminopropionate - - 2.00 - - (B4) p-Menthane-3,8-diol p-Menthane-3,8-diol - - - 2.00 - (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 0.50 0.50 0.50 0.50 (C) Ion exchange water 67.50 67.50 67.50 67.50 69.50 Total 100.00 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) 15 15 15 15 - Mass ratio (A)/(C) 0.44 0.44 0.44 0.44 0.43 Evaluation results Duration of repellent effect (min) 360 360 300 300 90 Odor intensity Score 3.0 2.7 2.7 3.3 0.7 determination B B B B A Long-term storage stability determination A - - A -

[table 3] table 3 Embodiment Comparison Example 1 5 6 7 1 2 3 4 (A1) Silicone KF-96Α-6cs Dimethicone 30.00 30.00 30.00 30.00 30.00 30.00 - - (B1) DEET N,N-Diethyltoluamide 2.00 1.00 0.10 0.01 - 4.00 2.00 4.00 (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 (C) Ion exchange water 67.50 68.50 69.40 69.49 69.50 65.50 97.50 95.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) 15 30 300 3000 - 7.5 - - Mass ratio (A)/(C) 0.44 0.44 0.43 0.43 0.43 0.46 - - Evaluation results Duration of repellent effect (min) 360 300 180 150 90 450 90 180 Odor intensity Score 3.0 2.3 1.3 1.0 0.7 3.7 3.0 3.7 determination B A A A A C B C Long-term storage stability determination A A A A - - - -

[Table 4] Table 4 Embodiment 1 8 9 10 11 12 13 14 15 16 17 18 19 20 twenty one (A1) Silicone KF-96Α-6cs Dimethicone 30.00 15.00 45.00 - - - - - - - - - - - - (A2) Silicone KF-96Α-10cs Dimethicone - - - - - - - - - - - - - - - (A3) Silicone KF-96Α-50cs Dimethicone - - - 30.00 15.00 45.00 - - - - - - - - - (A4) Silicone KF-96Α-200cs Dimethicone - - - - - - 30.00 15.00 45.00 - - - - - - (A5) EXCEPARL IPM Isopropyl myristate - - - - - - - - - 30.00 15.00 45.00 - - - (A6) NIKKOL Squalane Squalane - - - - - - - - - - - - 30.00 15.00 45.00 (B1) DEET N,N-Diethyltoluamide 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 (C) Ion exchange water 67.50 82.50 52.50 67.50 82.50 52.50 67.50 82.50 52.50 67.50 82.50 52.50 67.50 82.50 52.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) 15 7.5 22.5 15.0 7.5 22.5 15.0 7.5 22.5 15 7.5 22.5 15 7.5 22.5 Mass ratio (A)/(C) 0.44 0.18 0.86 0.44 0.18 0.86 0.44 0.18 0.86 - 0.18 0.86 - 0.18 0.86 Evaluation results Duration of repellent effect (min) 360 240 450 330 150 420 180 120 330 240 120 330 210 120 330 Odor intensity Score 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 2.7 2.7 2.7 determination B B B B B B B B B B B B B B B Long-term storage stability determination A A B A A B A A B A A B A A B

[table 5] table 5 Embodiment twenty two twenty three twenty four 25 26 27 28 29 30 31 (A1) Silicone KF-96Α-6cs Dimethicone - - - - - - 15.00 15.00 - 60.00 (A2) Silicone KF-96Α-10cs Dimethicone - - - - - - - - - - (A5) EXCEPARL IPM Isopropyl myristate - - - - - - 15.00 - 15.00 - (A6) NIKKOL Squalane Squalane - - - - - - - 15.00 15.00 - (A7) ASE-166K Cetyl-1,3-dimethylbutyl ether 30.00 15.00 45.00 - - - - - - - (A8) Polypropylene glycol 1,3-butylene glycol Polypropylene glycol/1,3-butylene glycol (mixture of 3/7 by mass ratio) - - - 30.00 15.00 45.00 - - - - (B1) DEET N,N-Diethyltoluamide 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 (C) Ion exchange water 67.50 82.50 52.50 67.50 82.50 52.50 67.50 67.50 67.50 37.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) 15.0 7.5 22.5 15.0 7.5 22.5 15 15 15 30 Mass ratio (A)/(C) 0.44 0.18 0.86 0.44 0.18 0.86 0.44 0.44 0.44 1.60 Evaluation results Duration of repellent effect (min) 180 120 330 180 120 270 330 300 240 600 Odor intensity Score 2.7 2.7 2.7 2.7 2.7 2.7 3.0 2.7 2.7 3.0 determination B B B B B B B B B B Long-term storage stability determination A B B A B B B B B C

[Table 6] Table 6 Comparison Example 1 3 5 6 7 8 9 (A1) Silicone KF-96Α-6cs Dimethicone 30.00 - 10.00 - - - - (A5) EXCEPARL IPM Isopropyl myristate - - - - - - - (A6) NIKKOL Squalane Squalane - - - - - - - (a1) Silicone KF-96-500cs Dimethicone - - - 30.00 - - - (a2) ZEMEA PROPANEDIOL Propylene glycol - - - - 30.00 - - (a3) Glycerine glycerin - - - - - 30.00 - (a4) Silicone KF-96-5000cs Dimethicone - - - - - - 30.00 (B1) DEET N,N-Diethyltoluamide - 2.00 2.00 2.00 2.00 2.00 2.00 (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 0.50 0.50 0.50 0.50 0.50 0.50 (C) Ion exchange water 69.50 97.50 87.50 67.50 67.50 67.50 67.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) - 0.00 5.0 0.00 0.00 0.00 0.00 Mass ratio (A)/(C) 0.43 0.00 0.11 0.00 0.00 0.00 0.00 Evaluation results Duration of repellent effect (min) 90 90 90 90 90 90 90 Odor intensity Score 0.7 3.0 3.0 3.0 2.7 2.3 3.0 determination A B B B B B B Long-term storage stability determination - - - - - - -

[Table 7] Table 7 Embodiment 1 32 33 34 (A1) Silicone KF-96Α-6cs Dimethicone 30.00 30.00 30.00 30.00 (B1) DEET N,N-Diethyltoluamide 2.00 2.00 2.00 2.00 (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 - - - (D2) PEMULEN TR-1 (Acrylates/Alkyl Acrylate (C10-C30) Ester) Crosslinked Polymer - 0.50 - - (D3) PEMULEN TR-2 (Acrylates/Alkyl Acrylate (C10-C30) Ester) Crosslinked Polymer - - 0.50 - (C) Ion exchange water 67.50 67.50 67.50 68.00 Total 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) 15 15 15 15 Mass ratio (A)/(C) 0.44 0.44 0.44 0.44 Evaluation results Duration of repellent effect (min) 360 360 360 360 Odor intensity Score 3.0 3.0 3.0 3.0 determination B B B B Long-term storage stability determination A - - -

[Table 8] Table 8 Embodiment Comparison Example 35 36 37 38 1 10 11 (A1) Silicone KF-96Α-6cs Dimethicone 30.00 30.00 30.00 30.00 30.00 - - (B4) p-Menthane-3,8-diol p-Menthane-3,8-diol 2.00 1.00 0.10 0.01 - 2.00 4.00 (D1) Aristoflex HMB (Ammonium Acryloyl Dimethyl Taurate/Beheneth-25 Methacrylate) Crosslinked Polymer 0.50 0.50 0.50 0.50 0.50 0.50 0.50 (C) Ion exchange water 67.50 68.50 69.40 69.49 69.50 97.50 95.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Mass ratio (A)/(B) 15 30 300 3000 - - - Mass ratio (A)/(C) 0.44 0.44 0.43 0.43 0.43 - - Evaluation results Duration of repellent effect (min) 300 240 180 150 90 90 150 Odor intensity Score 3.3 3.0 2.7 2.0 0.7 3.3 4.0 determination B B A A A B C Long-term storage stability determination A A A A - A C

As shown in Tables 2 to 8, the pest repellent time of the composition of the present invention (Examples 1 to 38) containing specific amounts of components (A) and (B) lasts for more than 2 hours and the repellent effect is excellent, and the unpleasant odor originating from the repellent components is suppressed. [Industrial Applicability]

According to the present invention, a pest repellent composition, a pest residence inhibiting composition, a pest repellent method, and a pest residence inhibiting method which are safe, have excellent and lasting repellent effect on pests, especially flying pests, and have less unpleasant odor from the repellent ingredients and are suitable for skin application can be provided.

Claims (16)

A pest repellent composition comprising the following components (A) and (B), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 or more: (A) a polyol selected from silicone oil, ester oil, ether oil, hydrocarbon oil, aliphatic alcohol and polyol having a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa‧s or less at 23°C measured by a B-type rotational viscometer; (B) one or more non-volatile liquid oily components selected from the group consisting of: 13% by mass or more and 99.995% by mass or less; (B) one or more incompatible components selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester, and 3-(acetylbutyl)aminopropionic acid ethyl ester: 0.005% by mass or more and 3% by mass or less. A pest residence inhibiting composition comprising the following components (A) and (B), wherein the mass ratio of component (A) to component (B) [(A)/(B)] is 7 or more: (A) a polysilicone oil, an ester oil, an ether oil, a hydrocarbon oil, a fatty alcohol, and a polyol having a surface tension of 40 mN/m or less at 25°C and a viscosity of 400 mPa‧s or less at 23°C measured by a B-type rotational viscometer; (B) one or more non-volatile liquid oily components selected from the group consisting of: 13% by mass or more and 99.995% by mass or less; (B) one or more taboo components selected from the group consisting of N,N-diethyltoluamide, 2-(2-hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester, and 3-(acetylbutyl)aminopropionic acid ethyl ester: 0.005% by mass or more and 3% by mass or less. The composition of claim 1 or 2, wherein component (A) is one or more selected from the group consisting of silicone oil, ester oil and hydrocarbon oil. For example, in the composition of claim 1 or 2, the surface tension of component (A) at 25°C is 15 mN/m or more. For example, in the composition of claim 1 or 2, the viscosity of component (A) at 23°C measured by a B-type rotational viscometer is 1 mPa‧s or more. For example, in the composition of claim 1 or 2, the mass ratio [(A)/(B)] of component (A) to component (B) is less than 3000. The composition of claim 1 or 2, which contains water as ingredient (C). For example, in the composition of claim 7, the content of component (C) is greater than 5% by mass and less than 86.995% by mass. As in claim 7, the mass ratio of component (A) to component (C) [(A)/(C)] is greater than 0.15 and less than 1.6. The composition of claim 7 is an oil-in-water composition. For the composition of claim 1 or 2, the content of the pest repellent other than component (A) and component (B) is less than 15% by mass. The composition of claim 1 or 2 further contains a thickener as component (D). For example, in the composition of claim 12, the content of component (D) is greater than 0.01 mass % and less than 5 mass %. The composition of claim 12, wherein component (D) is selected from one or more of the group consisting of water-soluble cationic polymers, anionic polymers, non-ionic polymers, and amphoteric polymers or bipolar polymers. A method for repelling pests, which comprises applying the composition of claim 1 on the surface of human skin. A method for inhibiting the residence of pests, which prevents the pests from residing on human skin by allowing the composition of claim 2 to attach to the limbs of the pests.