TWI723992B - Pesticidal composition comprising methomyl and lufenuron - Google Patents

Abstract

The present invention provides a composition comprising a synergistic pesticidally effective amount of methomyl and lufenuron in a weight ratio of about 14:1 to about 2:1. The composition is particularly useful for protecting and/or treating crops against insects of the order Lepidoptera.

Description

Pesticide composition containing Methomyl (METHOMYL) and Lufenuron (LUFENURON)

The present invention relates to a pesticide composition containing synergistic methomyl and lufenuron and its use in insect control. The composition is characterized in that the synergistic ratio of methomyl and lufenuron is about 14:1 to about 2:1.

Methomyl (( E , Z )-methyl N -{[(methylamino)carbonyl]oxy}methylthioformaldehyde oxime), also known as Larnate, Mesomile, Methomex and Nudrin, is an amino group Plant protection agent of formate, thioether and imine. It is commonly used as an insecticide to combat lepidopteran insect pests as well as coleopteran and certain hemipteran insect pests. It works by reversibly inactivating the insecticidal acetylcholinesterase. Common trade names include Acinate, Agrinate, DuPont 1179, Flytek, Kipsin, Lannate, Lanox, Memilene, Methavin, Methomex, Nudrin, NuBait, Pillarmate, and SD 14999.

Lufenuron (1-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-3-(2,6-difluorobenzyl (Di)-urea is a benzyl urea pesticide, which is effective for killing larvae by inhibiting the production of chitin. Without chitin, the larval fleas will not develop its exoskeleton. Because of this. When the internal organs are exposed to the air, insects will quickly die from dehydration after hatching and molting. Lufenuron is also effective as a fungicide against certain fungi.

Recently, pesticide compositions containing both methomyl and lufenuron have been reported. example For example, EP2260707 discloses a pesticide composition containing lufenuron and another pesticide active compound, wherein the pesticide active compound is selected from many examples, among which methomyl is mentioned. These components should be present in an amount such that the weight ratio of methomyl to lufenuron is in the range of 50:1 to 1:5.

EP1922931 discloses a method for controlling harmful organisms in genetically modified vegetable plants, said plants containing genes encoding insecticidal active proteins derived from Bacillus thuringiensis. The method includes applying an insecticidal effective amount of one or more compounds selected from various components, including methomyl and lufenuron. Methomyl should be applied in an amount of 50 to 5000 g/ha and lufenuron in an amount of 10 to 1000 g/ha.

CN101755735 series discloses an ultra-low volume (ULV) concentrate for controlling cotton noctuidae pests, and the concentrate is made into an electrostatic spray liquid formulation. Its active ingredient contains any of emamectin benzoate, methomyl, chlopyrifos, lufenuron, indoxacarb and chlorfenapyr Or two. In the case of using two active components, one component needs to be present in 0.1 to 90 parts and the other component is present in 90 to 0.1 parts, and further contains 15 parts of conductive agent and 20 parts of co-solvent. The composition is made up to 100 parts by weight by adding a solvent.

CN102626076 discloses an ultra-low volume liquid containing lufenuron and carbamate pesticides. Two examples containing methomyl and lufenuron in ratios of 1:1.43 and 500:1 are clearly revealed.

The combined composition containing methomyl and lufenuron in the cited prior art should be used to combat a wide range of insect pests, but in many cases it cannot effectively reduce the number of insects.

Therefore, the demand for effective pesticide compositions for controlling insects, especially Lepidoptera, especially Noctuidae, has not been met.

To meet this demand, the present invention provides a pesticide composition comprising methomyl and lufenuron, wherein the weight ratio of methomyl to lufenuron is about 14:1 to about 2:1. The weight ratio of methomyl to lufenuron is preferably about 14:1 to about 6.5:1. The weight ratio of methomyl to lufenuron is more preferably about 8:1.

The pesticide composition may also contain one or more agriculturally acceptable adjuvants. The one or more agriculturally acceptable adjuvants are preferably one or more solvents, carriers or surfactants or a combination thereof.

The pesticide composition may also include one or more other pesticides.

The pesticide composition may further include one or more herbicides, fungicides, nematicides and/or one or more fertilizers.

The pesticide composition can be formulated in liquid or solid form. For example, water-soluble liquid (SL), emulsion (EC), water emulsion (EW), microemulsion (ME), oil-based suspension (OD), flow suspension (FS), water dispersible granules (WG) , Water-soluble granules (SG), wettable powder (WP), soluble powder (SP), granules (GR), capsule granules (CG), fine granules (FG), large granules (GG), Aqueous suspension emulsion (SE), microcapsule suspension (CS), microparticles (MG) or preferably aqueous suspension (SC). The pesticide composition is preferably formulated as water dispersible granules (WG), water suspension (SC), emulsion (EC) or wettable powder (WP).

The concentration of methomyl and lufenuron in the composition may range from about 0.0005 wt% to about 95 wt%, preferably from about 5 wt% to about 70 wt%, more preferably from about 15 wt% to about 55 wt%.

The present invention also provides a use of the above-mentioned pesticide composition in protecting crops from infestation or treating crops that have been infested by insects. For example, cereals (wheat, barley, rye, oats, corn, rice, sorghum, triticale, and related crops); fruits, such as pears, stone fruits, and seedless fruits, such as apples, grapes, pears, plums, peaches , Apricots, cherries, and berries, for example Such as strawberries, raspberries and blackberries; legumes (beans, lentils, peas, soybeans); oil plants (canola, mustard, sunflower); Cucurbitaceae (cucurbits, cucumbers, watermelons); fiber plants (cotton, flax, hemp) , Jute); citrus, such as oranges, lemons, grapefruit and citrus; vegetables (spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, red peppers); coffee; and ornamental plants (flowers, such as roses) , Shrubs, broad-leaved trees and evergreen plants, such as conifers). The preferred crops that can be protected by the pesticide composition of the present invention are crops selected from the group consisting of fiber plants, legumes and cereals. More preferred crops that can be protected by the pesticide composition of the present invention are crops selected from cotton, corn, soybeans and rice.

The invention also provides a method for controlling insects. The method includes the step of applying the above-mentioned pesticide composition to a plant, a part of a plant or its location.

Insects that can be controlled by the pesticide composition of the present invention include Lepidoptera species. Preferred insects include species from the family Noctuidae.

The present invention also provides a method for manufacturing the above-mentioned pesticide composition. The method includes providing methomyl and lufenuron, and mixing methomyl and lufenuron in a weight ratio of about 40:1 to about 2:1, preferably about 40:1 to about 6.5:1, and more preferably about 8:1 Urea step.

The method also includes the step of adding one or more agriculturally acceptable adjuvants and/or one or more other pesticides, wherein the one or more adjuvants are preferably one or more solvents, carriers or surfactants or a combination thereof.

Detailed description of the invention

The present inventors surprisingly found that the weight ratio of methomyl to lufenuron of about 14:1 to about 2:1 provides a synergistic effect that cannot be expected by simply combining the two components, even if a lower amount of active ingredient is used. It also effectively reduces the number of insects on various established agricultural plants. The weight ratio of the two components is about 14:1 to about 2:1, especially 14:1, 13:1, 12:1, 11:1, 10:1, 9.5:1, 9:1, 8.5 :1, 8:1, 7.5:1, 7:1, 6.5:1, 2:1, more preferably 14:1, 13:1, 12:1 11:1, 10:1, 9.5:1, 9:1, 8.5:1, 8:1, 7.5:1, 7:1, 6.5:1. A particularly preferred weight ratio of methomyl to lufenuron is about 8:1.

The concentration of methomyl and lufenuron in the composition may be in the range of 0.0005 to 95% by weight. Preferably, the concentration of each of the two active components is about 1% to about 95% by weight, about 2% to about 92% by weight, about 3% to about 91% by weight, and about 4% to about 90% by weight, About 5, 6, 7, 8, 9 or 10% by weight to about 90% by weight, about 15 to about 85% by weight, about 20 to about 80% by weight, about 25 to about 75% by weight, about 30 to about 70% by weight %, about 35 to about 65% by weight, about 40 to about 60% by weight, about 45 to about 55% by weight, and more preferably about 50% by weight in the composition. The methomyl concentration in the composition is preferably 1% to 70%, more preferably 15%-50%; further preferably about 20%-50%. The concentration of lufenuron in the composition may be about 0.005%-20%, more preferably about 0.1%-7.5%; further preferably about 0.5%-5%.

The composition of the present invention may contain the two compounds methomyl and lufenuron in various physical forms such as solid or liquid form. Alternatively, a composition that is easy to prepare may be provided, such as a premix containing two compounds. Typical liquid compositions include emulsions, suspensions (including suspensions containing microcapsules), solutions, emulsions and flow agents. It is preferably an emulsion containing two compounds in various ratios, or a two-phase emulsion (or microemulsion) with one compound in each phase. Particularly suitable composition forms are emulsions (EC) and aqueous suspensions (SC), the general formulations of which are known to those skilled in the art. According to the intended purpose and the current environment, the pesticide composition of the present invention can also be directly sprayable or diluted solution, coatable paste, diluted emulsion, wettable powder, water-soluble powder, dispersible powder, Provided in the form of a powder, either as granules or as an encapsulation in one or more polymers. Particularly preferred forms are water-dispersible granules, water suspensions, emulsions, and wettable powders.

The composition of the present invention can also be provided and/or applied in combination with one or more other insecticides, herbicides, fungicides, nematicides and/or one or more fertilizers. Therefore, in relation to When one or more insecticides, herbicides, fungicides, nematicides and/or one or more fertilizers are used together, the composition may include one or more insecticides, herbicides, fungicides, nematicides Pesticides and/or one or more fertilizers; or can be formulated so that the composition containing the pesticides in the proportions of the present invention is used in one or more other pesticides, herbicides, fungicides, nematicides and/or one or more fertilizers To be applied before, at the same time or after.

Lufenuron and methomyl are used in pure form in their respective formulations. Their solid compounds are usually used in a specific particle size, or preferably used together with at least one or more adjuvants commonly used in pesticide formulation technology. Each agriculturally acceptable adjuvant includes, for example, extenders such as solvents, solid carriers, and surfactants. It is also considered to use a combination of adjuvants to prepare the pesticide composition of the present invention, such as one or more (e.g., 2 or 3) solvents, one or more (e.g., 2 or 3 carriers) and/or one or more (e.g., 2 or 3 types) Combination of surfactants.

Suitable solvents include, but are not limited to, aromatic hydrocarbons or partially hydrogenated aromatic hydrocarbons such as xylene mixtures, alkylated naphthalene or tetralin, aliphatic or alicyclic hydrocarbons such as paraffin or cyclohexane, alcohols such as ethanol, propanol or butylene Alcohols, glycols and their ethers and esters such as propylene glycol, dipropylene glycol ether, diethylene glycol or 2-methoxyethanol or 2-ethoxyethanol, ketones such as cyclohexanone, isophorone or diacetone alcohol , Strong polar solvents such as N-methylpyrrolidone, dimethylsulfide or N,N-dimethylformamide, water, vegetable oil or epoxidized vegetable oil such as rapeseed oil, castor oil, coconut oil or soybean oil or epoxidized Rapeseed oil, castor oil, coconut oil or soybean oil, and silicon oil, petroleum fractions or hydrocarbons such as mineral oil, aromatic solvents, paraffin oil, etc., vegetable oils such as from soybean, rapeseed, olive, castor, sunflower, coconut , Corn, cottonseed, flax, palm, peanut, safflower, sesame, tung tree, etc., the esters of the above-mentioned vegetable oils, the esters of monohydric or dihydric alcohols, trihydric alcohols or other lower polyols such as 2-ethylhexyl hard Fatty acid ester, n-butyl oleate, isopropyl myristate, propylene glycol dioleate, dioctyl succinate, dibutyl adipate, dioctyl phthalate, etc., mono-, di- and Esters of polycarboxylic acids, etc. Particularly preferred organic solvents include, but are not limited to, toluene, xylene, naphtha, crop oil, acetone, methyl ethyl ketone, cyclohexanone, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol Monomethyl ether and diethylene glycol monomethyl ether, methanol, ethanol, isopropanol, pentanol, ethylene glycol, glycerol, N-methyl-2-pyrrolidone, N,N-dimethyl alkyl amide , Dimethyl sulfoxide and Solvesso ^TM 200, aromatic hydrocarbons and combinations thereof. In certain embodiments, water is the carrier used to dilute the concentrate.

Suitable solid carriers include, but are not limited to, natural mineral fillers, silicic acid, broken bricks, sepiolite, calcite, sand, talc, pyrophyllite clay, silica, attapulgus clay, kaolin ( Also known as Chinese clay), kieselguhr, chalk, diatomaceous earth, lime, calcium carbonate, bentonite, Fuller's earth, cottonseed husk, wheat flour, soybean flour, pumice, wood chips , Walnut shell powder, lignin, cellulose and its derivatives such as carboxymethyl cellulose, powdered plant residues, etc., and combinations thereof.

Suitable surfactants include, but are not limited to, nonionic, cationic and/or anionic surfactants or surfactant mixtures with good emulsifying, dispersing and wetting properties. The nonionic surfactant is preferably a polyglycol ether derivative of aliphatic or alicyclic alcohol, saturated or unsaturated fatty acid, and alkylphenol. The cationic surfactant is preferably a quaternary ammonium salt containing at least one C ₈ -C ₂₂ alkyl group as an N-substituent, and an unsubstituted or halogenated lower alkyl group, benzyl group or hydroxy-lower group as other substituents. alkyl. Suitable anionic surfactants can be water-soluble soaps as well as water-soluble synthetic surface-active compounds, such as sodium lauryl sulfate. In addition, synthetic surfactants can be used, preferably fatty sulfonates, fatty sulfates, sulfonated benzimidazole derivatives or alkylarylsulfonates.

Agriculturally acceptable adjuvants also include, but are not limited to, antifreeze, antifoaming agents such as sodium lignosulfonate, compatibilizing agents, chelating agents, neutralizing agents and buffers, corrosion inhibitors, coloring agents Or dyes, fragrances, penetration aids, wetting agents, spreading agents, sticking agents, dispersants, thickeners, freezing point inhibitors, antimicrobial agents Agents, crop oils, safeners, binders (for example, for seed formulations), protective colloids, emulsifiers, tackifiers, and mixtures thereof. Exemplary agriculturally acceptable adjuvants include, but are not limited to, crop oil concentrate (mineral oil (85%) + emulsifier (15%)), nonylphenol ethoxylate, benzyl coco alkyl dimethyl Benzylcocoalkyldimethyl quaternary ammonium salt, and blends of petroleum hydrocarbons, alkyl esters and organic acids. The preferred emulsifier is tristyrylphenol ethoxylate.

The composition is particularly useful for protecting crops from infestation or treating crops that have been infested by insects. The preferred crops that can be protected by the pesticide composition of the present invention are crops selected from the group consisting of fiber plants, legumes and cereals. The preferred crops that can be protected by the pesticide composition of the present invention are crops selected from the group consisting of cotton, corn, soybeans and rice.

Methomyl and lufenuron can be applied simultaneously or consecutively (for example, in the same day) at short intervals to the plants, plant parts, and/or surrounding areas that need to be controlled. Methomyl and lufenuron can be applied to the plant, one or more parts of the plant (for example, leaves or seeds), or surroundings in any order.

In order to control unfavorable insects and protect crops, the pesticide composition can be applied before, during or after the crops to be protected or treated. It is particularly preferred to apply the composition 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and/or 20 days after planting or sowing. It is particularly preferred to apply for only one day, such as one application on the 10th day after planting or sowing. Of course, the composition can be applied whenever deemed necessary, for example more than once or twice, for example three, four, five or more times during the growth cycle of each plant. Preferably, the pesticide composition is applied to plants, plant parts or their locations.

The composition of the present invention can be applied by conventional ground or aerial dusters, sprayers and granulators, by adding to irrigation water or paddy water, and other conventional means known to those skilled in the art.

The composition is particularly effective for controlling Lepidopteran insects. The composition is particularly useful for controlling insects of the Noctuidae family. The preferred Noctuidae targets are cotton leafworm (Alabama argillacea ), velvet bean caterpillar ( Anticarsia gemmatalis ), tobacco budworm ( Heliothis virescens ), and Heliothis virescens Moth ( Spodoptera frugiperda ).

The method for preparing each of the above-mentioned pesticide compositions is also disclosed. The method includes providing methomyl and lufenuron in any suitable form, as disclosed above. The method further includes the step of mixing methomyl and lufenuron in a weight ratio of about 14:1 to about 2:1. The method may further include the step of adding one or more disclosed agriculturally acceptable adjuvants and/or one or more disclosed other pesticides. Particularly preferred adjuvants are as disclosed above and include one or more solvents, carriers or surfactants. Combinations of these adjuvants can also be used.

An exemplary preferred composition is

Preferred specific embodiment 1:

Or preferred specific embodiment 2:

Methomyl 160g

In the following examples, 20 samples used in 8 different control experiments showed the synergistic effect of methomyl and lufenuron in a specific weight ratio of about 14:1 to about 2:1. In the specific ratio disclosed here, compared with the larger amount of active ingredients at different ratios, a smaller amount of active ingredients (metacarb and lufenuron) can be used to effectively control insects.

Example

A. Formulation

a) Water dispersible granule formulation:

The water-dispersible granules (WG) were prepared by the following method: the finely ground active ingredient and additives (0.5% by weight SUPRALATE ^® (sodium lauryl sulfate, Witco Inc., Greenwich)), 5 Weight% REAX ^® 88B (sodium lignosulfonate, Westvaco Corp), potassium carbonate (make up to 100%)) were mixed, and then squeezed and dried in a jet dryer.

碳酸鉀 47.5重量% E.g,

Potassium carbonate 47.5% by weight

b) Water suspension:

The aqueous suspension (SC) was prepared by the following method: the finely ground active ingredient and additives (10% by weight propylene glycol, 5% by weight tristyryl phenol ethoxylate, 1% by weight sodium lignosulfonate, 1% by weight carboxymethyl cellulose, 1% by weight silicone oil (in the form of 75% by weight emulsion in water), 0.1% by weight xanthan gum, 0.1% by weight NIPACIDE BIT 20 (Clariant, Asia), Water (make up to 100% by weight)) and mix.

E.g,

c) Emulsion:

The emulsion (EC) was prepared by the following method: the active ingredients and additives (50g tristyrylphenol ethoxylate, 1g silicone oil, 300g N-methyl-2-pyrrolidone, SOLVESSO 200 (make up to 1kg)) mixing.

For example, methomyl 200g

d) Wettable powder:

The wettable powder (WP) is prepared by the following method: the finely ground active ingredient is mixed with the adjuvant (50 g Dispersogen 1494, kaolin (make up to 1000 g)), and then air milled with a jet mill.

E.g,

表1：WP=可濕性粉劑；EC=乳劑；ULV=超低容量；WG=水分散性粒劑；SC=水懸劑。 According to the method described above, the formulations were prepared with the amounts of the active ingredients methomyl and/or lufenuron as shown in Table 1 below:

Table 1: WP=wettable powder; EC=emulsion; ULV=ultra-low volume; WG=water dispersible granules; SC=water suspension.

B. Practical application

The effects of samples 1-20 shown in Table 1 have been tested in 8 independent examples shown below. The actual application rate of methomyl and/or lufenuron is expressed as grams per hectare (g/ha). The percentage value of insect infestation has been determined with reference to the initial population size placed on each plant.

Biological Example 1-Cotton-Cotton Leaf Worm ( Alabama argillacea )

The cotton leafworm (Alabama argillacea ) was cultivated separately in the laboratory. Count the number of insects, collect the insects, and apply them to healthy young cotton plants separately. Each formulation was diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (Table 2)

Biological Example 2-Soybean-Velvet bean caterpillar ( Anticarsia gemmatalis )

The velvet bean caterpillars ( Anticarsia gemmatalis) were cultivated in the laboratory. The number of insects is counted, collected, and then separately applied to healthy young soybean plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (table 3)

Biological Example 3-Cotton- Heliothis virescens (Heliothis virescens)

The tobacco budworm (Heliothis virescens) was cultivated separately in the laboratory. The number of insects is counted, collected, and then separately applied to healthy young cotton plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (Table 4)

Biological Example 4-Corn-Spodoptera frugiperda ( Spadoptera frugiperda )

Separately cultivate Spodoptera frugiperda (Spodoptera frugiperda) in the laboratory. The number of insects is counted, collected, and then separately applied to healthy young corn plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (table 5)

Biological Example 5-Cotton- Spodoptera frugiperda (Spodoptera frugiperda)

Separately cultivate Spodoptera frugiperda (Spodoptera frugiperda) in the laboratory. The number of insects is counted, collected, and then separately applied to healthy young cotton plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (Table 6)

Biological Example 6-Soybean- Spodoptera frugiperda (Spodoptera frugiperda)

Separately cultivate Spodoptera frugiperda (Spodoptera frugiperda) in the laboratory. The number of insects is counted, collected, and then separately applied to healthy young soybean plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (Table 7)

Biological Example 7-Wheat- Spodoptera frugiperda (Spodoptera frugiperda)

Separately cultivate Spodoptera frugiperda (Spodoptera frugiperda) in the laboratory. The number of insects is counted, collected, and then separately applied to healthy young wheat plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (Table 8)

Rice leaf beetle (rice leafroller, Cnaphalocrocis medinalis) - Biological Examples Example 8 Rice

In the laboratory were cultured rice leaf beetle (rice leaf roller, Cnaphalocrocis medinalis). The number of insects is counted, collected, and then separately applied to healthy young wheat plants. The formulation is diluted and then sprayed on the plants. After being kept in a greenhouse at 21-25°C and 80% relative atmospheric humidity for 10 days, the remaining insect populations were tested. (Table 9)

The combination of methomyl and lufenuron provides an unexpected synergistic effect within a small range defined by the specific weight ratio of methomyl and lufenuron of about 1:0.1-0.3, preferably 1:0.2. As shown in the above examples, compared with other formulations, the combination of the two active ingredients provides an enhanced effect against pest infestation at a specific weight ratio, even with a reduced amount of active ingredients. Further increasing or decreasing the weight ratio of methomyl to lufenuron results in a decrease in efficacy, as more active ingredients are required to achieve comparable results.

Claims (13)

A pesticide composition comprising methomyl and lufenuron in a weight ratio of 8:1. The pesticide composition according to claim 1, which further comprises one or more agriculturally acceptable adjuvants. The pesticide composition according to claim 2, wherein the one or more agriculturally acceptable adjuvants are one or more solvents, carriers or surfactants or a combination thereof. The pesticide composition according to any one of claims 1 to 3, which further contains one or more other pesticides. The pesticide composition according to any one of claims 1 to 3, which further comprises one or more herbicides, fungicides, nematicides and/or one or more fertilizers. The pesticide composition according to any one of claims 1 to 3, which is formulated in a liquid or solid form. The pesticide composition according to any one of claims 1 to 3, wherein the concentration of methomyl and lufenuron is 0.5% by weight to 95% by weight. A use of the pesticide composition according to any one of claims 1 to 7 in protecting or treating crops infested by insects. The use according to claim 8, wherein the insects include species from the order Lepidoptera. A method for controlling insects, the method comprising the step of applying the pesticide composition according to any one of claims 1 to 7 to plants or plant parts or their locations. The method of claim 10, wherein the insect includes a species from the order Lepidoptera. A method for preparing the pesticide composition according to any one of claims 1 to 7, which comprises the following steps: providing methomyl and lufenuron, and mixing methomyl and lufenuron in a weight ratio of 8:1. The method according to claim 12, which further comprises the step of adding one or more agriculturally acceptable adjuvants and/or one or more other pesticides.