TWI798452B - 隱形眼鏡產品 - Google Patents
隱形眼鏡產品 Download PDFInfo
- Publication number
- TWI798452B TWI798452B TW108120918A TW108120918A TWI798452B TW I798452 B TWI798452 B TW I798452B TW 108120918 A TW108120918 A TW 108120918A TW 108120918 A TW108120918 A TW 108120918A TW I798452 B TWI798452 B TW I798452B
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- TW
- Taiwan
- Prior art keywords
- contact lens
- solution
- lens solution
- item
- comfort
- Prior art date
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- 239000000882 contact lens solution Substances 0.000 claims abstract description 70
- 230000002708 enhancing effect Effects 0.000 claims abstract description 16
- 239000004615 ingredient Substances 0.000 claims abstract description 10
- 239000004220 glutamic acid Substances 0.000 claims abstract description 8
- 239000000178 monomer Substances 0.000 claims abstract description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 21
- 238000004806 packaging method and process Methods 0.000 claims description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 239000000872 buffer Substances 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 239000013538 functional additive Substances 0.000 claims description 9
- 150000002433 hydrophilic molecules Chemical class 0.000 claims description 9
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- 229920002643 polyglutamic acid Polymers 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 239000008363 phosphate buffer Substances 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- 229960003160 hyaluronic acid Drugs 0.000 claims description 4
- 230000003204 osmotic effect Effects 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- -1 alkyl sulfosuccinate Chemical compound 0.000 claims description 3
- 229910021538 borax Inorganic materials 0.000 claims description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004327 boric acid Substances 0.000 claims description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 3
- 229920001451 polypropylene glycol Polymers 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 150000001642 boronic acid derivatives Chemical group 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 229950008882 polysorbate Drugs 0.000 claims description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 2
- LWLHCZLCSDUDEL-UHFFFAOYSA-O C[N+](C)(C)CC(O)=P(=O)CCOC(=O)C=C Chemical compound C[N+](C)(C)CC(O)=P(=O)CCOC(=O)C=C LWLHCZLCSDUDEL-UHFFFAOYSA-O 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000005461 lubrication Methods 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000010408 film Substances 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 4
- 229920002413 Polyhexanide Polymers 0.000 description 4
- 239000006172 buffering agent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 108700022290 poly(gamma-glutamic acid) Proteins 0.000 description 3
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- SEILKFZTLVMHRR-UHFFFAOYSA-N 2-phosphonooxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOP(O)(O)=O SEILKFZTLVMHRR-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000028006 Corneal injury Diseases 0.000 description 1
- 206010011026 Corneal lesion Diseases 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010047531 Visual acuity reduced Diseases 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
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- 238000002791 soaking Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
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- 239000004328 sodium tetraborate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 235000019158 vitamin B6 Nutrition 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
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- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D171/00—Coating compositions based on polyethers obtained by reactions forming an ether link in the main chain; Coating compositions based on derivatives of such polymers
- C09D171/02—Polyalkylene oxides
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/60—Additives non-macromolecular
- C09D7/61—Additives non-macromolecular inorganic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/65—Additives macromolecular
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
- C11D1/06—Ether- or thioether carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
- C11D1/146—Sulfuric acid esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/667—Neutral esters, e.g. sorbitan esters
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
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Abstract
本發明公開一種能增加濕潤感的隱形眼鏡溶液及隱形眼鏡產品，其中隱形眼鏡溶液包含一舒適性增強成分。舒適性增強成分的含量，以隱形眼鏡溶液的總量為100wt%計，為0.01wt%至3wt%，舒適性增強成分具有麩胺酸單體，且舒適性增強成分的分子量為3000Dalton至1,500,000Dalton，如此隱形眼鏡溶液可具有介於1cps至3cps之間的黏度。藉此，本發明能有效提升隱形眼鏡的配戴舒適度。
Description
本發明涉及一種隱形眼鏡溶液，特別是涉及一種能增加濕潤感的隱形眼鏡溶液，例如隱形眼鏡的包裝溶液、儲存溶液、清潔溶液或養護溶液，以及使用其的隱形眼鏡產品。
資訊社會來臨後，頻繁使用智慧型手機或電腦等3C產品的結果，不僅導致國人罹患近視的比率不斷升高，近視年齡層也有逐年下降的趨勢。考慮到美觀性與使用方便性，配戴隱形眼鏡是一種非常有價值的選擇。
由於大多數視力不佳的人都有長時間配戴隱形眼鏡的習慣，配戴隱形眼鏡時的舒適度就顯得非常重要。配戴隱形眼鏡時，鏡片的透氧率、保濕力與潤滑度等，都是決定舒適度的重要指標。雖然隱形眼鏡在材質經過不斷改良之後，鏡片的透氧率、保濕力與潤滑度等特性均有所改善，但是依使用環境與配戴者眼睛的健康狀況不同，配戴者的眼睛，隨著配戴隱形眼鏡的時間增加，容易因缺氧、缺水而感到不適，甚至引發角膜受傷、病變，尤其長時間處於冷氣房。
通常，在隱形眼鏡保養液中添加保濕劑(如：甘油)，只能減緩配戴隱形眼鏡時的不適感。因此，目前亟需一種新穎的眼科配方來與隱形眼鏡配合使用，以提升配戴隱形眼鏡時的舒適感，並讓眼角膜保持健康狀態。
本發明所要解決的技術問題在於，針對現有技術的不足提供一種能增加濕潤感的隱形眼鏡溶液，其能長時間維持眼睛的舒適。並且，提供一種使用此隱形眼鏡溶液的隱形眼鏡產品
為了解決上述的技術問題，本發明所採用的其中一技術方案是，提供一種能增加濕潤感的隱形眼鏡溶液，其包含一舒適性增強成分，其中所述舒適性增強成分的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至3wt%，所述舒適性增強成分具有麩胺酸單體，且所述舒適性增強成分的分子量為3000Dalton至1,500,000Dalton，其中所述隱形眼鏡溶液的黏度為1cps至3cps。
在本發明的一實施例中，所述舒適性增強成分選自γ-聚麩胺酸(poly-gamma-glutamic acid)、其鹽類以及γ-聚麩胺酸酯(poly-gamma-glutamate)中的至少一種。
在本發明的一實施例中，所述隱形眼鏡溶液還進一步包含一表面活性劑，所述表面活性劑的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至2wt%，其中，所述表面活性劑選自聚山梨醇酯、磺基丁二酸烷基酯、聚乙二醇、聚氧丙烯二醇、十二烷基硫酸鈉以及月桂基硫酸鈉中的至少一種。
在本發明的一實施例中，所述隱形眼鏡溶液還進一步包含一緩衝劑，所述緩衝劑的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至5wt%，其中，所述緩衝劑為硼酸鹽緩衝劑或磷酸鹽緩衝劑。
在本發明的一實施例中，所述硼酸鹽緩衝劑包含硼酸、氯化鈉以及硼酸鈉中的至少一種。
在本發明的一實施例中，所述磷酸鹽緩衝劑包含氯化鈉、
磷酸二氫鈉、磷酸氫二鈉、磷酸二氫鉀以及磷酸氫二鉀中的至少一種。
在本發明的一實施例中，所述隱形眼鏡溶液還進一步包含一親水性分子，所述親水性分子的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至5wt%，其中，所述親水性分子選自聚乙烯醇、纖維素及其衍生物、聚乙二醇、棕櫚酸、聚乙烯吡咯啶酮及其共聚物、2-甲基丙烯醯氧乙基磷酸膽鹼及其共聚物以及玻尿酸中的至少一種。
在本發明的一實施例中，所述隱形眼鏡溶液還進一步包含至少一功能性添加劑，所述功能性添加劑的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至5wt%，其中，所述功能性添加劑選自抗菌劑、維生素或其組合。
在本發明的一實施例中，所述隱形眼鏡溶液的pH值為6至8，且滲透壓為250Osmol/Kg至450Osmol/Kg。
為了解決上述的技術問題，本發明所採用的另外一技術方案是，提供一種隱形眼鏡產品，其包括一包裝結構、一具有前述配方的隱形眼鏡溶液以及一隱形眼鏡鏡片，所述隱形眼鏡溶液與所述隱形眼鏡鏡片一起被密封在所述包裝結構內，且所述隱形眼鏡鏡片浸泡於所述隱形眼鏡溶液中。
本發明的其中一有益效果在於，本發明的能增加濕潤感的隱形眼鏡溶液及隱形眼鏡產品，其能通過“舒適性增強成分的含量為0.01wt%至3wt%，且舒適性增強成分具有麩胺酸單體”的技術方案，以提升有效提升隱形眼鏡的配戴舒適度，並讓眼角膜保持健康狀態。
為使能更進一步瞭解本發明的特徵及技術內容，請參閱以下有關本發明的詳細說明與圖式，然而所提供的圖式僅用於提供參考與說明，並非用來對本發明加以限制。
100:隱形眼鏡產品
110:包裝結構
111:容器
112:覆片
120:包裝溶液
130:隱形眼鏡鏡片
圖1為本發明的隱形眼鏡產品的立體示意圖。
圖2為本發明的隱形眼鏡產品的平面示意圖。
以下是通過特定的具體實施例來說明本發明所公開有關“能增加濕潤感的隱形眼鏡溶液及隱形眼鏡產品”的實施方式，本領域技術人員可由本說明書所公開的內容瞭解本發明的優點與效果。本發明可通過其他不同的具體實施例加以施行或應用，本說明書中的各項細節也可基於不同觀點與應用，在不悖離本發明的構思下進行各種修改與變更。另外，本發明的附圖僅為簡單示意說明，並非依實際尺寸的描繪，事先聲明。以下的實施方式將進一步詳細說明本發明的相關技術內容，但所公開的內容並非用以限制本發明的保護範圍。
應當可以理解的是，雖然本文中可能會使用到“第一”、“第二”、“第三”等術語來描述各種元件或者信號，但這些元件或者信號不應受這些術語的限制。這些術語主要是用以區分一元件與另一元件，或者一信號與另一信號。另外，本文中所使用的術語“或”，應視實際情況可能包括相關聯的列出項目中的任一個或者多個的組合。
除非另外定義，否則本文中使用的所有技術及科學術語，都具有與本領域技術人員通常所理解含義相同的含義。當術語以單數形式出現時，涵蓋此術語的複數形式。
除非另有指示，否則本文中提到的所有百分比都為重量百分比。當提供一系列上、下限範圍時，涵蓋所提到的範圍的所有組合，如同明確列出各組合。
為了增進隱形眼鏡的配戴舒適感，本發明提供一種隱形眼
鏡溶液，其主要包含一眼科可接受的液體媒介(如水)以及一舒適性增強成分；液體媒介的含量，以隱形眼鏡溶液的總量為100wt%計，可為75wt%至99wt%，較佳為85wt%至99wt%。本發明的隱形眼鏡溶液可作為隱形眼鏡的包裝溶液、儲存溶液、清潔溶液或養護溶液，但不限於此。
使用時，可以適當的方式將隱形眼鏡鏡片與隱形眼鏡溶液接觸，使有效量的舒適性增強成分附著於隱形眼鏡鏡片上，然後再將隱形眼鏡鏡片戴於眼睛上。舉例來說，可將隱形眼鏡鏡片浸泡於隱形眼鏡溶液中一段時間，或將隱形眼鏡溶液滴於隱形眼鏡鏡片表面；然而，本發明不以上述所舉的例子為限。本文中術語“有效量(effective amount)”是指一用量可傳遞足夠量的舒適性增強成分至隱形眼鏡鏡片產生保濕和潤滑效果。
在本實施例中，舒適性增強成分至少具有麩胺酸單體，且具有高吸水性和黏滯性。在舒適性增強成分的存在下，隱形眼鏡溶液具有介於1cps至3cps之間的黏度。進一步而言，舒適性增強成分可選自γ-聚麩胺酸(poly-gamma-glutamic acid,γ-PGA)、其鹽類以及γ-聚麩胺酸酯(poly-gamma-glutamate)中的至少一種；舒適性增強成分的分子量可為3000Dalton至1,500,000Dalton；舒適性增強成分的含量，以隱形眼鏡溶液的總量為100wt%計，為0.01wt%至3wt%(如0.05wt%、0.1wt%、0.2wt%、0.3wt%、0.4wt%、0.5wt%、0.6wt%、0.7wt%、0.8wt%、0.9wt%、1.0wt%、1.5wt%、2.0wt%或2.5wt%)。
值得說明的是，當本發明的隱形眼鏡溶液與隱形眼鏡鏡片充分接觸時，舒適性增強成分可以在隱形眼鏡鏡片表面上形成一層薄膜；此薄膜具有良好的透氧性、表面親水性、濕潤性及潤滑性，而能有效提升隱形眼鏡的配戴隱舒適度。
本發明的隱形眼鏡溶液還可包含緩衝劑、表面活性劑、親
水性分子及其他功能性添加劑。緩衝劑可以協助調節隱形眼鏡溶液的酸鹼值pH和滲透壓，從而隱形眼鏡溶液可以發揮預期的效果，即對眼睛提供有益效果。隱形眼鏡溶液的pH值可為6至8，隱形眼鏡溶液的滲透壓可為250Osmol/Kg至450Osmol/Kg。
在本實施例中，緩衝劑可為硼酸鹽或磷酸鹽緩衝劑；緩衝劑的含量，以隱形眼鏡溶液的總量為100wt%計，可為大於0且小於5wt%(如0.5wt%、1wt%、1.5wt%、2wt%、2.5wt%、3wt%、3.5wt%或4wt%)。硼酸鹽緩衝劑可包含硼酸、氯化鈉及硼酸鹽(如四硼酸鈉)，但不限於此。磷酸鹽緩衝劑可包含氯化鈉及磷酸鹽(如磷酸二氫鈉、磷酸氫二鈉、磷酸二氫鉀及磷酸氫二鉀等)，但不限於此。
表面活性劑可以更好的發揮舒適性增強劑的效果；表面活性劑可選自聚山梨醇酯80(TWEEN 80)、磺基丁二酸烷基酯(SBFA 30)、聚乙二醇、聚氧丙烯二醇(polyoxypropylene glycol)、十二烷基硫酸鈉(sodium dodecyl sulfate,SDS)及月桂基硫酸鈉(sodium lauryl sulfate,SLS)中的至少一種，但不限於此。表面活性劑的含量，以隱形眼鏡溶液的總量為100wt%計，可為0.01wt%至2wt%，優選為0.01wt%至1wt%(如0.05wt%、0.1wt%、0.2wt%、0.3wt%、0.4wt%、0.5wt%、0.6wt%、0.7wt%、0.8wt%或0.9wt%)。
親水性分子可以增加眼睛的濕潤感。親水性分子可選自聚乙烯醇(polyvinyl alcohol,PVA)、纖維素及其衍生物、聚乙二醇(polyethylene glycol,PEG)、棕櫚酸、聚乙烯吡咯啶酮(polyvinylpyrrolidone,PVP)及其共聚物、2-甲基丙烯醯氧乙基磷酸膽鹼(2-methacryloyloxyethyl phosphorylcholine,MPC)及共聚物以及玻尿酸(hyaluronic acid)中的至少一種，但不限於此。親水性分子的總量為100wt%計，可為0.01wt%至5wt%，較佳為0.01wt%至3wt%(如0.5wt%、1
wt%、1.5wt%、2wt%或2.5wt%)。纖維素及其衍生物可舉出：羥丙基甲基纖維素(hydroxypropyl methylcellulose，HPMC)、羧甲基纖維素(carboxymethyl cellulose，CMC)、甲基纖維素(methyl cellulose，MC)、羥乙基纖維素(hydroxyethyl cellulose，HEC)、陽離子纖維素衍生物等。
功能性添加劑可選自抗菌劑、維生素、類黃酮物質及多酚類物質中的至少一種，但不限於此。功能性添加劑的含量，以隱形眼鏡溶液的總量為100wt%計，可為0.01wt%至5wt%。抗菌劑的具體例包括：聚六亞甲基雙胍(polyhexamethylene biguanide，PHMB)、聚六亞甲基雙胍的水溶性鹽、聚胺丙基雙胍(polyaminopropyl biguanide，PAPB)及聚胺丙基雙胍的水溶性鹽等；維生素的具體例包括：維生素B6(鹽酸吡多醇，pyridoxine hydrochloride)、維生素B12(氰鈷胺，cyanocobalamin)及維生素E(人工合成的α-生育酚，DL-alpha-tocopherol)。然而，本發明不以上述所舉的例子為限。
表1中列出本發明的隱形眼鏡溶液的幾個代表性實驗例，然而，本發明不以上述所舉的例子為限。
參閱圖1及圖2所示，本發明的隱形眼鏡產品100的其中一較佳實施方式為隱形眼鏡包裝，其包括：一包裝結構110、一隱形眼鏡溶液120及一隱形眼鏡鏡片130。隱形眼鏡溶液120與隱形眼鏡鏡片130一起被密封在包裝結構110內，並經過滅菌處理(如：高溫或高壓滅菌)，其中隱形眼鏡鏡片130浸泡於隱形眼鏡溶液120中。
進一步而言，包裝結構110包括一容器111及一覆片112，容器111用於容置隱形眼鏡溶液120與隱形眼鏡鏡片130，覆片112可剝離的結合於容器111上，以將容器111的開口封閉。在本實施例中，容器111的材料可為塑膠，且可對隱形眼鏡鏡片130提供合理程度的保護；覆片112的材料可為金屬或塑膠；隱形眼鏡鏡片130的材料可為水膠(hydrogel)或矽水膠(silicone hydrogel)，且視需要可含有功能性成分(如藍光吸收成分或UV吸收成分)。然而，本發明不以上述所舉的例子為限。
值得說明的是，浸泡時隱形眼鏡溶液120中的舒適性增強成分會進入隱形眼鏡鏡片130或附著於隱形眼鏡鏡片130上，而產生保濕和潤滑效果，增加配戴的舒適感；本發明的隱形眼鏡溶液120尤其適用於長時間佩戴隱形眼鏡者。
[測試項目]
製造眼科產品：
依表1中記載的配方製備隱形眼鏡溶液作為包裝溶液，再將多片晶碩公司生產的水膠隱形眼鏡分別泡入根據實驗例1-8的隱形眼鏡溶液中，然後進行密封及高溫滅菌處理(125℃、30分鐘)，如此即完成了隱形眼鏡產品的製造；其中鏡片的表面性質給10人進行盲測評分，從1分到10分，分數越高表示潤滑性越好，平均結果顯示於下表2中。
測試水膜破裂的時間：
依表1中記載的配方製備隱形眼鏡溶液作為包裝溶液，再將多片晶碩公司生產的水膠隱形眼鏡分別泡入根據實驗例1-8的隱形眼鏡溶液中，然後取出這些隱形眼鏡，記錄鏡片表面上水膜破裂的時間，結果顯示於下表3中；而從表3可以看出，在隱形眼鏡溶液中加入有效含量的γ-聚麩胺酸，可以延長水膜破裂時間。
臨床測試結果：
依表1中記載的配方製備隱形眼鏡溶液作為包裝溶液，再將多片晶碩公司生產的水膠隱形眼鏡分別泡入根據實驗例2-8的隱形眼鏡溶液中，然後取出這些隱形眼鏡，挑選11位試驗者來使用這些隱形眼鏡，並對異物感、乾澀感等項目進行評價，結果顯示於下表4中。關於自我感覺的舒適感，得分越高表示異物感、乾澀感越明顯；另外，關於非侵入式淚膜破裂時間(NIBUT)，秒數越大表示眼睛呈現越保濕的狀態。
[實施例的有益效果]
本發明的能增加濕潤感的隱形眼鏡溶液及隱形眼鏡產品，其能通過“舒適性增強成分的含量為0.01wt%至3wt%，且舒適性增強成分具有麩胺酸單體”的技術方案，以提升有效提升隱形眼鏡的配戴舒適度，並讓眼角膜保持健康狀態。
更進一步來說，舒適性增強成分可以在隱形眼鏡鏡片表面上形成一層薄膜，此薄膜具有良好的透氧性、表面親水性、潤濕性及潤滑性；因此，本發明的隱形眼鏡溶液適用於長時間佩戴隱形眼鏡者。
以上所公開的內容僅為本發明的優選可行實施例，並非因此侷限本發明的申請專利範圍，所以凡是運用本發明說明書及圖式內容所做的等效技術變化，均包含於本發明的申請專利範圍內。
100:隱形眼鏡產品
110:包裝結構
111:容器
112:覆片
120:包裝溶液
130:隱形眼鏡鏡片
Claims (9)
- 一種隱形眼鏡產品，包括一包裝結構、一隱形眼鏡溶液以及一隱形眼鏡鏡片，所述隱形眼鏡溶液與所述隱形眼鏡鏡片一起被密封在所述包裝結構內，且所述隱形眼鏡鏡片浸泡於所述隱形眼鏡溶液中；其中，所述隱形眼鏡溶液包含一舒適性增強成分，用以在所述隱形眼鏡鏡片的表面上形成一層薄膜，其中所述舒適性增強成分的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.1wt%至3wt%，所述舒適性增強成分具有麩胺酸單體，且所述舒適性增強成分的分子量為3000Dalton至1,500,000Dalton，其中，所述隱形眼鏡溶液的黏度為1cps至3cps。
- 如申請專利範圍第1項所述的隱形眼鏡產品，其中，所述舒適性增強成分選自γ-聚麩胺酸(poly-gamma-glutamic acid)、其鹽類以及γ-聚麩胺酸酯(poly-gamma-glutamate)中的至少一種。
- 如申請專利範圍第1項所述的隱形眼鏡產品，其中，所述隱形眼鏡溶液還進一步包含一表面活性劑，所述表面活性劑的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至2wt%，其中，所述表面活性劑選自聚山梨醇酯、磺基丁二酸烷基酯、聚乙二醇、聚氧丙烯二醇、十二烷基硫酸鈉以及月桂基硫酸鈉中的至少一種。
- 如申請專利範圍第1項所述的隱形眼鏡產品，其中，所述隱形眼鏡溶液還進一步包含一緩衝劑，所述緩衝劑的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至5wt%，其中，所述緩衝劑為硼酸鹽緩衝劑或磷酸鹽緩衝劑。
- 如申請專利範圍第4項所述的隱形眼鏡產品，其中，所述硼酸鹽緩衝劑包含硼酸、氯化鈉以及硼酸鈉中的至少一種。
- 如申請專利範圍第4項所述的隱形眼鏡產品，其中，所述磷酸鹽緩衝劑包含氯化鈉、磷酸二氫鈉、磷酸氫二鈉、磷酸二氫鉀以及磷酸氫二鉀中的至少一種。
- 如申請專利範圍第1項所述的隱形眼鏡產品，其中，所述隱形眼鏡溶液還進一步包含一親水性分子，所述親水性分子的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至5wt%，其中，所述親水性分子選自聚乙烯醇、纖維素及其衍生物、聚乙二醇、棕櫚酸、聚乙烯吡咯啶酮及其共聚物、2-甲基丙烯醯氧乙基磷酸膽鹼及其共聚物以及玻尿酸中的至少一種。
- 如申請專利範圍第1項所述的隱形眼鏡產品，其中，所述隱形眼鏡溶液還進一步包含至少一功能性添加劑，所述功能性添加劑的含量，以所述隱形眼鏡溶液的總量為100wt%計，為0.01wt%至5wt%，其中，所述功能性添加劑選自抗菌劑、維生素或其組合。
- 如申請專利範圍第1項所述的隱形眼鏡產品，其中，所述隱形眼鏡溶液的pH值為6至8，且滲透壓為250Osmol/Kg至450Osmol/Kg。
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| TWI907151B (zh) | 2024-11-08 | 2025-12-01 | 晶碩光學股份有限公司 | 隱形眼鏡用液體組成物及隱形眼鏡產品 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112094582A (zh) | 2020-12-18 |
| US20200393698A1 (en) | 2020-12-17 |
| TW202100681A (zh) | 2021-01-01 |
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