TWI796268B - Multi-band photoacoustic endoscopy probe diagnosis device and its operation method - Google Patents

Abstract

A multi-band photoacoustic endoscopic probe diagnostic device and its operation method, the ultrasonic receiving unit has There are a plurality of probes and catheters that trigger the photoacoustic effect to generate ultrasonic signals, drive the ultrasonic receiving unit to receive the ultrasonic signals, and send them to the computer for diagnostic analysis to achieve the purpose of early monitoring.

Description

Multi-band photoacoustic endoscopy probe diagnosis device and its operation method

The present invention relates to a probe diagnosis device and its operation method, in particular to a multi-band photoacoustic endoscope probe diagnosis device and its operation method.

Globally, up to 1.93 million new cases of colorectal cancer can be diagnosed every year, and in 2020, 930,000 people will die from colorectal cancer, which is indeed a trend of rapid increase. According to clinical statistics, the standardized mortality rate is increasing by 12% year by year, and colorectal cancer is the third most common cancer in the world. Looking at the world, due to the intensification of population aging, it is estimated that by 2040, compared with 2020, the burden of cancer will increase by 50%. By then, the number of new cancer cases will reach nearly 30 million, highlighting the correlation between colon cancer Research will be exactly the direction that needs to be solved urgently and deserves attention.

The main cause of colorectal cancer complications is that the addicted meat and benign tumors that grow on the intestinal wall transform into malignant tumors after decades of lesions, which then affect digestion The normal function of the tract, what's more, it can cause internal bleeding in the abdomen, which is life-threatening. Its formation is caused by mutations in the genes of intestinal mucosal cells (), which can be attributed to two factors: genetics and environment. Among them, there are two rare genetic diseases that can lead to colorectal cancer, which are (1) familial adenomatous polyposis (Familial adenomatous polyposis, FAP), and (2) hereditary non-polyposis colorectal cancer (HNPCC), and environmental factors are the intestinal environment caused by long-term contact of mucosal cells, including high intake of Amount of red meat, ingestion of carcinogenic factors, alcohol consumption, insufficient fiber intake, obesity, less exercise, aging, etc. Colon cancer starts with blood in the stool or rectal bleeding that lasts for more than three weeks Changes in normal bowel habits, abdominal pain, unexplained weight loss, fatigue, wheezing, etc. And the status of their cancer is usually divided into four stages. The first stage is that the cancer is still in the lining of the colorectal bowel; the second stage is that the cancer has spread to the muscle layer around the intestine; the third stage is that the cancer has spread to nearby lymph nodes. and Stage IV, when the cancer has spread to other parts of the body.

At present, screening techniques for colorectal cancer can be divided into the following five types, including: (1) flexible optical endoscope (sigmoid colonoscope and colonoscope), (2) computerized tomography, (3) Fecal occult blood screening, (4) digital rectal examination, and (5) capsule endoscopy. Among the above, screening with capsule endoscopy technology is the latest inspection technology in the medical field. Before the test, let the subject take the capsule device containing the microphotography equipment, and when the capsule travels through the digestive organs, the internal tissues including the esophagus, stomach, and colorectum are recorded, and the anus is reached The capsule is expelled, and this method has the advantage of causing minimal disruption to the recipient, who does not have to take specific medications and does not have to accept invasive interventions. However, the disadvantage of capsule endoscopy technology is that because the capsule is not human-controllable when it moves, it will involuntarily rotate due to the direction of the lens, so it will inevitably ignore important parts, and each time the inspection takes place. The required cost is very high and cannot meet the actual cost demand.

In fact, since colorectal cancer is asymptomatic in the early stage, and the lesion cannot be found in the early stage, it is almost impossible to effectively treat it when it is discovered. If an early monitoring mechanism can be developed, the growth on the intestinal wall can be removed as soon as possible. Reducing the probability of disease occurrence can also help to effectively improve the chances of curing the patient. Therefore, the industry currently needs to be able to design and manufacture a multi-band photoacoustic endoscopic probe diagnostic device with high imaging resolution and reduced catheter size to take on the heavy responsibility of the monitoring mechanism, which is indeed a topic worthy of research at present.

The present invention relates to a multi-band photoacoustic endoscopic probe diagnosis device and its operation method. A plurality of ultrasonic probes are used to receive signals of different frequency bands, and the low-frequency ultrasonic probes can contribute to the imaging depth of the entire tissue wall. At the same time, the high-frequency ultrasonic probe can be used to obtain fine analysis of the lumen area, and finally the best rectal image can be obtained.

In view of the prior art, the purpose of the present invention is to provide a multi-band photoacoustic endoscopic probe diagnostic device, including: a laser unit for providing laser light. A fixed light source excitation unit is used to receive and transmit the laser light. The ultrasonic receiving unit is used to receive the ultrasonic signal with photoacoustic effect. The ultrasonic receiving unit includes at least one probe and a catheter. The probes are arranged in the catheter. One of the probes is used to receive the ultrasonic signal. frequency signal. The multi-frequency photoacoustic micro-probe driving unit is used to drive the laser unit to excite the laser light, and drive the ultrasonic receiving unit to receive the ultrasonic signal. The ultrasonic encoding excitation unit is used for encoding the ultrasonic signal, demodulating the ultrasonic signal, and sending it to a computer for analysis. And, the programmable logic array control unit controls the multi-frequency photoacoustic micro-probe driving unit to drive the laser laser unit to excite the laser light, and controls the multi-frequency photoacoustic micro-probe driving unit to drive the ultrasonic receiving unit to receive the laser light. Ultrasonic signal.

The operation method of the multi-band photoacoustic endoscope probe diagnostic device of the present invention, wherein the programmable logic array control unit controls the laser light to pass through the optical fiber and the reflector to lead to the part to be tested, and the part to be tested generates heat and expands , causing the photoacoustic effect to generate the ultrasonic signal, the ultrasonic probe receives the acoustic signal, the programmable logic array control unit controls the multi-frequency photoacoustic micro-probe driving unit to drive the ultrasonic receiving unit and rotates After receiving the ultrasonic signal, the ultrasonic code excites the unit to encode the ultrasonic signal, demodulate the ultrasonic signal, and send it to the computer for analysis and confirmation.

Another object provided by the multi-frequency photoacoustic endoscopic probe diagnostic device and its operating method of the present invention is that the size of the laser light spot is 1000 microns and the wavelength is 532 nanometers.

Another purpose provided by the multi-band photoacoustic endoscopic probe diagnostic device and its operating method of the present invention is that the light source generated by the fixed light source excitation unit is the original light source, and the original light source is not filtered and spectroscopic The light source of the program.

Another purpose provided by the multi-band photoacoustic endoscopic probe diagnostic device and its operation method of the present invention is that the ultrasonic receiving unit includes three probes, which are three bidirectional multi-band ultrasonic probes, and the three bidirectional The multi-band ultrasonic probe receives one of the frequency signals of the ultrasonic signal respectively, and the center frequencies of these frequency signals are 5/12M Hz, 5/20M Hz and 5/30M Hz.

The multi-band photoacoustic endoscopic probe diagnostic device and its operating method of the present invention provide another object that each of the two-way multi-band ultrasonic probes is rectangular in plane, and the three bi-directional multi-band ultrasonic probes The long sides are connected with each other to form a structure with a regular triangle cross section.

Another object provided by the multi-band photoacoustic endoscopic probe diagnostic device and its operating method of the present invention is that the long sides of the three bidirectional multi-band ultrasonic probes are connected to each other by insulating fillers.

Another object provided by the multi-frequency photoacoustic endoscopic probe diagnostic device and its operating method of the present invention is that the material of the isolation filler is transparent epoxy resin.

The advantage of the multi-band photoacoustic endoscopic probe diagnosis device and its operating method of the present invention is that it can provide more comprehensive colorectal visualization to achieve early monitoring of colorectal lesions.

In view of the fact that colorectal cancer is asymptomatic in the early stage, another advantage of the multi-band photoacoustic endoscopic probe diagnostic device and its operating method of the present invention is that it can remove the growths on the intestinal wall in the early stage of tumor development, It can not only reduce the probability of lesions, but also improve the chances of curing patients.

100: Multi-band photoacoustic endoscopy probe diagnostic device

110: laser laser unit

120: fixed light source excitation unit

130: Ultrasonic receiving unit

132: micro motor

134: Rotation axis

136: Mirror

138: optical fiber

140: Multi-frequency photoacoustic micro-probe drive unit

150: Ultrasonic coding excitation unit

160: Programmable logic array control unit

170: computer

310: Two-way multi-band ultrasonic probe

320: isolation packing

C: Conduit

D: Probe

L: laser light

N: Refers to the North Pole

S: guide pole

Fig. 1 is a schematic diagram of a multi-band photoacoustic endoscopic probe diagnosis device of the present invention.

Fig. 2 is a schematic diagram of the ultrasonic receiving unit of the present invention.

Fig. 3A is a schematic diagram of the probe of the present invention.

Fig. 3B is a schematic cross-sectional view of the probe of the present invention.

Since the various aspects and embodiments are only illustrative and non-restrictive, after reading this specification, those with ordinary knowledge may also have other aspects and embodiments without departing from the scope of the present invention. According to the following detailed description and scope of patent application, the features and advantages of these embodiments will be more evident.

First, please refer to FIG. 1 for a schematic diagram of the multi-frequency photoacoustic endoscopic probe diagnostic device of the present invention, and please also refer to FIG. 2 for a schematic diagram of the multi-frequency endoscopic catheter of the present invention.

Please refer again to the schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention shown in FIG. Exciting unit 120 , ultrasonic receiving unit 130 , multi-frequency photoacoustic micro-probe driving unit 140 , ultrasonic coded exciting unit 150 , and programmable logic array control unit 160 .

Please refer to FIG. 1 , which is a schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention. The laser unit 110 of the present invention is used to provide laser light.

Please still refer to FIG. 1 , which is a schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention. The fixed light source excitation unit 120 of the present invention is used to receive and transmit laser light L. It should be noted that the size of the light spot of the laser light L of the present invention is 1000 micrometers, and the wavelength is 532 nanometers. To limit the scope of the present invention, various dimensions are also included in the scope of the present invention. It should be noted that the light source generated by the fixed light source excitation unit 120 of the present invention is an original light source, wherein the original light source is a light source that has not undergone a filtering process or a spectroscopic process.

1 is a schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention. The ultrasonic receiving unit 130 of the present invention is used to receive ultrasonic signals with photoacoustic effects.

Please refer to FIG. 2 for a schematic diagram of the multi-frequency endoscopic catheter of the present invention. The aforementioned ultrasonic receiving unit 130 includes a plurality of probes D and a catheter C, and a plurality of probes D are arranged in the catheter C. The plurality of probes D are used to receive frequency signals among the ultrasonic signals. The ultrasonic receiving unit 130 further includes a micro motor 132 , a rotating shaft 134 , and a mirror 136 . In addition, the ultrasonic receiving unit 130 is connected to an optical fiber 138 for receiving the laser light L transmitted by the optical fiber 138 . The plurality of probes D are connected to the rotating shaft 134 , and the rotating shaft 134 is connected to the micro motor 132 . When the micro motor 132 rotates, the rotating shaft 134 drives the plurality of probes D to rotate and scan to receive ultrasonic signals. N shown in FIG. 2 refers to the north pole or N pole of the magnet, and S shown in FIG. 2 refers to the index pole or S pole of the magnet.

Please refer to FIG. 3A for a schematic diagram of the probe of the present invention, and FIG. 3B for a schematic cross-sectional view of the probe of the present invention. The ultrasonic receiving unit 130 of the present invention includes three probes, which are three bidirectional multi-frequency band ultrasonic probes 310, and the three bidirectional multi-band ultrasonic probes 310 respectively receive one of the frequency signals of the ultrasonic signals, namely Responsible for receiving frequency signals of different frequencies, wherein the center frequency of the frequency signal is 5/12M Hz, 5/20M Hz, and 5/30M Hz.

Still please refer to FIG. 3A for a schematic diagram of the probe of the present invention, and FIG. 3B for a schematic cross-sectional view of the probe of the present invention. In FIG. 3A , each two-way multi-band ultrasonic probe 310 is rectangular in plan. The long sides of the three bi-directional multi-band ultrasonic probes 310 are connected to each other by insulating fillers 320 to form a structure with a regular triangle cross section, as shown in FIG. 3B . It should be noted that the material of the isolation filler 320 is transparent epoxy resin.

As shown in Figure 1, the schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention, the multi-frequency photoacoustic micro-probe driving unit 140 of the present invention is used to drive the laser unit 110 to excite the laser light L, and to drive The ultrasonic receiving unit 130 receives ultrasonic signals.

Just like the schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention shown in FIG. 1 , the ultrasonic encoding excitation unit 150 of the present invention is used to encode and demodulate ultrasonic signals, and transmit them to the computer 170 for analysis.

Still Fig. 1 is a schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention, the programmable logic array control unit 160 of the present invention is used to control the multi-frequency photoacoustic micro-probe driving unit 140 to drive the laser unit 110 excites the laser light L, and is used to control the multi-frequency photoacoustic micro-probe driving unit 140 to drive the ultrasonic receiving unit 130 to receive ultrasonic signals.

Continuing from the schematic diagram of the multi-band photoacoustic endoscopic probe diagnostic device of the present invention as shown in Figure 1, the programmable logic array control unit 160 of the present invention is used to control the laser light L to pass through (Figure 2) the optical fiber 138 and (Figure 2) The reflection mirror 136 leads to the part to be measured. When the laser light L irradiates the part to be tested, heat energy and expansion will be generated, causing the photoacoustic effect to generate ultrasonic signals, so the ultrasonic probe D can receive the acoustic signals, and the programmable logic array control unit 160 controls the multi-frequency photoacoustic micrometer. The probe driving unit 140 drives the micro motor 132 of the ultrasonic receiving unit 130 to rotate, drives the probe D to rotate through the rotating shaft 134, and receives ultrasonic signals in a rotating manner, while the ultrasonic encoding excitation unit 150 encodes the ultrasonic signals and decodes them. Adjust the ultrasonic signal and send it to the computer 170 for analysis and confirmation.

To sum up, the multi-band photoacoustic endoscopic probe diagnosis device of the present invention can provide a low-frequency ultrasonic probe to obtain a deep penetration contribution to the imaging of the entire tissue wall. At the same time, the high-frequency ultrasonic probe can obtain fine analysis of the lumen area, Finally, the best rectal image was obtained.

The advantage of using the multi-band photoacoustic endoscopic probe diagnostic device of the present invention is that it can provide more comprehensive colorectal visualization, so as to achieve the purpose of early monitoring of colorectal lesions, and in view of the fact that colorectal cancer has no symptoms in the early stage, this Another advantage of the invention is that it can be used in the early stage of tumor development, With the use of the present invention, the overgrown flesh on the intestinal wall can be removed, which can not only reduce the probability of early pathological changes, but also improve the chance of curing the patient.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the patent scope of the present invention; all other equivalent changes or modifications that do not deviate from the spirit disclosed in the present invention should be included in the following within the scope of the patent application.

100: Multi-band photoacoustic endoscopy probe diagnostic device

110: laser laser unit

120: fixed light source excitation unit

130: Ultrasonic receiving unit

140: Multi-frequency photoacoustic micro-probe drive unit

150: Ultrasonic coding excitation unit

160: Programmable logic array control unit

170: computer

Claims (9)

A multi-band photoacoustic endoscopic probe diagnosis device, comprising: a laser laser unit, used to provide a laser light; a certain light source excitation unit, used to receive and transmit the laser light; an ultrasonic receiving unit, used to Used to receive an ultrasonic signal with a photoacoustic effect, the ultrasonic receiving unit includes a plurality of probes and a catheter, the plurality of probes are arranged in the catheter, and the plurality of probes are used to receive the ultrasonic signal A frequency signal; a multi-frequency photoacoustic micro-probe driving unit is used to drive the laser laser unit to excite the laser light, and drive the ultrasonic receiving unit to receive the ultrasonic signal; an ultrasonic code excitation unit is used to encoding the ultrasonic signal to demodulate the ultrasonic signal and send it to a computer for analysis; and a programmable logic array control unit for controlling the multi-frequency photoacoustic micro-probe driving unit to drive the The emitting laser unit excites the laser light, and controls the multi-frequency photoacoustic micro-probe driving unit to drive the ultrasonic receiving unit to receive the ultrasonic signal. The multi-band photoacoustic endoscopic probe diagnostic device as claimed in Claim 1, wherein the size of the laser light spot includes 1000 microns, and the wavelength is 532 nanometers. The multi-band photoacoustic endoscopic probe diagnostic device as described in Claim 1, wherein the light source generated by the fixed light source excitation unit is an original light source, and the original light source is the light source without a filtering process and a spectroscopic process. The multi-band photoacoustic endoscopic probe diagnosis device according to claim 1, wherein the ultrasonic receiving unit includes three bidirectional multi-band ultrasonic probes. The multi-band photoacoustic endoscopic probe diagnostic device as described in claim 4, wherein the three bidirectional multi-band ultrasonic probes respectively receive one frequency signal of the ultrasonic signal, and the center frequency of the plurality of frequency signals is 5/12M Hz, 5/20M Hz and 5/30M Hz. The multi-band photoacoustic endoscopic probe diagnostic device as described in claim 4, wherein each of the two-way multi-band ultrasonic probes is rectangular in plane, and the long sides of the three bi-directional multi-band ultrasonic probes are connected to each other to form a The cross-section is a regular triangle structure. The multi-band photoacoustic endoscopic probe diagnostic device as described in claim 6, wherein the long sides of the three bidirectional multi-band ultrasonic probes are connected to each other by insulating fillers. According to the multi-band photoacoustic endoscope probe diagnostic device as described in Claim 7, wherein the material of the isolation filler includes a transparent epoxy resin. The multi-band photoacoustic endoscopic probe diagnostic device as described in claim 1, wherein the operation method of the device includes the programmable logic array control unit controlling the laser light to guide to a part to be tested through an optical fiber and a mirror , the part to be tested generates thermal energy and expansion, triggers a photoacoustic effect to generate the ultrasonic signal, receives the acoustic signal from the ultrasonic probe, and the programmable logic array control unit controls the multi-frequency photoacoustic micro-probe driving unit To drive the ultrasonic receiving unit and receive the ultrasonic signal in a rotating manner, an ultrasonic encoding excitation unit encodes the ultrasonic signal, demodulates the ultrasonic signal, and sends it to a computer for analysis and confirmation.

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