TWI607009B - 苯並二氮雜呯衍生物的托西酸鹽及其多晶型、它們的製備方法和醫藥用途 - Google Patents
苯並二氮雜呯衍生物的托西酸鹽及其多晶型、它們的製備方法和醫藥用途 Download PDFInfo
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- TWI607009B TWI607009B TW101126578A TW101126578A TWI607009B TW I607009 B TWI607009 B TW I607009B TW 101126578 A TW101126578 A TW 101126578A TW 101126578 A TW101126578 A TW 101126578A TW I607009 B TWI607009 B TW I607009B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110269686 | 2011-08-31 | ||
| CN2011104568640A CN102964349A (zh) | 2011-08-31 | 2011-12-23 | 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201309704A TW201309704A (zh) | 2013-03-01 |
| TWI607009B true TWI607009B (zh) | 2017-12-01 |
Family
ID=47755291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101126578A TWI607009B (zh) | 2011-08-31 | 2012-07-24 | 苯並二氮雜呯衍生物的托西酸鹽及其多晶型、它們的製備方法和醫藥用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (2) | CN102964349A (fr) |
| TW (1) | TWI607009B (fr) |
| WO (1) | WO2013029431A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2081921T3 (da) | 2006-07-10 | 2011-01-03 | Paion Uk Ltd | Korttidsvirkende benzodiazepinsalte og deres polymorfe former |
| EP2450039A1 (fr) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam) |
| PT2852389T (pt) | 2012-05-22 | 2017-12-13 | Paion Uk Ltd | Composições que compreendem benzodiazepinas de ação rápida |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| CN104146970A (zh) * | 2013-05-05 | 2014-11-19 | 王元青 | 治疗精神疾病的冻干粉针剂 |
| CN103232454A (zh) * | 2013-05-05 | 2013-08-07 | 王元青 | 治疗精神疾病的药物 |
| PL3162804T3 (pl) * | 2014-07-23 | 2020-04-30 | Jiangsu Nhwaluokang Pharmaceutical Research And Development Co., Ltd. | Nowa pochodna benzodiazepiny i jej zastosowanie |
| CN105130996B (zh) * | 2015-08-07 | 2017-05-03 | 成都倍特药业有限公司 | 苯并二氮杂*衍生物的1,5‑萘二磺酸盐及晶型和它们的制备方法 |
| CN106854197B (zh) * | 2015-12-08 | 2020-09-01 | 浙江亚太药业股份有限公司 | 一种吡啶衍生物的多晶型及其制备方法、用途 |
| CN110511224A (zh) * | 2016-04-08 | 2019-11-29 | 四川科伦药物研究院有限公司 | 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途 |
| WO2017178663A1 (fr) | 2016-04-14 | 2017-10-19 | Paion Uk Limited | Benzodiazépines à usage nasal et inhalées par voie orale |
| CN108503644B (zh) * | 2016-12-09 | 2019-06-14 | 成都倍特药业有限公司 | 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途 |
| CN109422798B (zh) * | 2017-08-22 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 一种苯基丙酰胺类衍生物的游离碱晶型及其制备方法 |
| CN108047229A (zh) * | 2017-12-15 | 2018-05-18 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类化合物 |
| CN109956947A (zh) * | 2017-12-25 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | 一种cns抑制剂的新晶型、制备方法及用途 |
| US11708368B2 (en) | 2018-02-13 | 2023-07-25 | Jiangsu Nhwaluokang Pharmaceutical Research And Development Co., Ltd. | Crystal form of ethyl (S)-3-(8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-4-yl)propanoate hydrochloride |
| ES2803099B2 (es) * | 2019-07-22 | 2021-11-08 | Moehs Iberica Sl | Procedimiento de obtención de besilato de remimazolam amorfo |
| CN114478535B (zh) * | 2020-10-23 | 2024-02-09 | 成都苑东生物制药股份有限公司 | 一种苯磺酸瑞马唑仑ii晶型的制备方法 |
| CN113717176B (zh) * | 2021-10-09 | 2022-07-05 | 上海再启生物技术有限公司 | 一种制备瑞马唑仑的方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000069836A1 (fr) * | 1999-05-14 | 2000-11-23 | Glaxo Group Limited | Benzodiazepines a action breve |
| CN101501019A (zh) * | 2006-07-10 | 2009-08-05 | Paion英国有限公司 | 短效苯并二氮杂盐及其多晶型 |
| EP1812112B1 (fr) * | 2004-10-19 | 2011-04-27 | GlaxoSmithKline LLC | Dérivés de benzodiazépine comme inhibiteurs de ROCK kinases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| EP2305647A1 (fr) * | 2009-09-18 | 2011-04-06 | PAION UK Limited | Procédé de préparation d'ester de méthyle d'acide 3-[(4S)-8-bromo-1-méthyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazépine-4-yl] propionique ou son sulfonate de benzène, et composants utiles dans ce procédé |
-
2011
- 2011-12-23 CN CN2011104568640A patent/CN102964349A/zh active Pending
-
2012
- 2012-07-11 WO PCT/CN2012/078487 patent/WO2013029431A1/fr not_active Ceased
- 2012-07-11 CN CN201280003321.6A patent/CN103221414B/zh active Active
- 2012-07-24 TW TW101126578A patent/TWI607009B/zh active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000069836A1 (fr) * | 1999-05-14 | 2000-11-23 | Glaxo Group Limited | Benzodiazepines a action breve |
| EP1812112B1 (fr) * | 2004-10-19 | 2011-04-27 | GlaxoSmithKline LLC | Dérivés de benzodiazépine comme inhibiteurs de ROCK kinases |
| CN101501019A (zh) * | 2006-07-10 | 2009-08-05 | Paion英国有限公司 | 短效苯并二氮杂盐及其多晶型 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013029431A1 (fr) | 2013-03-07 |
| CN102964349A (zh) | 2013-03-13 |
| CN103221414A (zh) | 2013-07-24 |
| CN103221414B (zh) | 2014-08-27 |
| TW201309704A (zh) | 2013-03-01 |
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