TWI577372B - High-effect skin germicide - Google Patents
High-effect skin germicide Download PDFInfo
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- TWI577372B TWI577372B TW102115470A TW102115470A TWI577372B TW I577372 B TWI577372 B TW I577372B TW 102115470 A TW102115470 A TW 102115470A TW 102115470 A TW102115470 A TW 102115470A TW I577372 B TWI577372 B TW I577372B
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- skin
- bactericide
- release agent
- efficiency
- sustained release
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- 230000002070 germicidal effect Effects 0.000 title description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 34
- 239000003795 chemical substances by application Substances 0.000 claims description 32
- 239000003899 bactericide agent Substances 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 238000013268 sustained release Methods 0.000 claims description 17
- 239000012730 sustained-release form Substances 0.000 claims description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 229920005862 polyol Polymers 0.000 claims description 9
- 150000003077 polyols Chemical class 0.000 claims description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 229920000609 methyl cellulose Polymers 0.000 claims description 8
- 239000001923 methylcellulose Substances 0.000 claims description 8
- 235000010981 methylcellulose Nutrition 0.000 claims description 8
- 239000000645 desinfectant Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000003205 fragrance Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000000465 moulding Methods 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000001814 pectin Substances 0.000 claims description 4
- 229920001277 pectin Polymers 0.000 claims description 4
- 235000010987 pectin Nutrition 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 230000036548 skin texture Effects 0.000 claims description 3
- 229920000591 gum Polymers 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 230000003385 bacteriostatic effect Effects 0.000 description 6
- 239000000417 fungicide Substances 0.000 description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 229910017604 nitric acid Inorganic materials 0.000 description 4
- 244000215068 Acacia senegal Species 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229960000292 pectin Drugs 0.000 description 3
- 230000037368 penetrate the skin Effects 0.000 description 3
- 230000002459 sustained effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
本發明係關於一種殺菌劑，特別關於一種能夠延長殺菌時間以及提供持續性抑菌作用的高效率皮膚殺菌劑。 The present invention relates to a bactericide, and more particularly to a high-efficiency skin bactericide capable of prolonging sterilization time and providing sustained bacteriostatic action.
一般傳染病的傳播途徑之中，最常見的就是接觸傳染。因此勤洗手是避免及預防細菌或病毒的感染的最佳方法。然而，傳統洗手方式，在時間上的需求較多，常因太忙碌而忽略，或身處環境不便而無法洗手。在舒適方面，因為經常沖洗和使用洗劑讓皮膚易受刺激而導致乾燥不適、皮膚粗糙不柔順或過敏情形等。 Among the common routes of transmission of infectious diseases, the most common is contact infection. Therefore, washing hands frequently is the best way to avoid and prevent infection by bacteria or viruses. However, traditional hand washing methods require more time, often neglected because they are too busy, or unable to wash their hands when they are inconvenient. In terms of comfort, because the lotion is often washed and used to make the skin susceptible to irritation, resulting in dry discomfort, rough skin, or suppleness.
因此，酒精性免水洗手劑之產品克服了上述之不方便性，在無法用水洗手的時候，酒精性免水洗手劑就是最能應急的隨身清潔劑，只要滴一滴酒精性免水洗手劑於手上，雙手互相搓揉至洗手劑完全揮發至乾即能隨時做好手部消毒殺菌的工作。目前市面上、實驗室或醫院清潔手部時皆是會以酒精性免水洗手劑來清潔消毒。雖然，酒精已是較安全的消毒劑，但長期或頻繁地使用含酒精之免水洗手劑仍會引起皮膚的乾燥與刺激缺點。 Therefore, the alcohol-based water-free hand washing product overcomes the above inconvenience. When it is impossible to wash hands with water, the alcohol-based water-free hand washing agent is the most emergency portable cleaning agent, as long as a drop of alcohol-based water-free hand washing agent is applied. On the hands, hands rub each other until the hand washing agent is completely evaporated to dryness, so that the hand disinfection can be done at any time. At present, when cleaning hands on the market, in the laboratory or in hospitals, alcohol-based water-free hand washing agents are used for cleaning and disinfecting. Although alcohol is a safer disinfectant, long-term or frequent use of alcohol-free water-based hand washing agents can still cause dryness and irritation of the skin.
此外，酒精屬高揮發性物質，停留在皮膚表面的時間相當短暫，所以其殺菌或抑菌效果相當有限，因此為了提高殺菌或抑菌效果，則必須頻繁地使用，如此更將造成皮膚的不適。再者酒精屬非 親脂性，因此無法有效地深入皮膚紋理。 In addition, alcohol is a highly volatile substance, and the time spent on the surface of the skin is quite short, so its sterilization or bacteriostatic effect is quite limited. Therefore, in order to improve the sterilization or bacteriostatic effect, it must be frequently used, which will cause skin discomfort. . Further alcohol It is lipophilic and therefore does not effectively penetrate deep into the skin texture.
因此，如何提供一種高效率皮膚殺菌劑，能夠延長殺菌時間、持續性抑菌作用並能有效地深入皮膚紋理，進而提升殺菌效果，實為當前重要課題之一。 Therefore, how to provide a high-efficiency skin bactericide, which can prolong the sterilization time, the sustained bacteriostasis effect, and effectively penetrate the skin texture, thereby enhancing the bactericidal effect, is one of the current important issues.
有鑒於上述課題，本發明之一目的在於提供一種高效率皮膚殺菌劑，能夠延長殺菌時間與持續性抑菌作用，並能有效地深入皮膚紋理，進而提升殺菌效果。 In view of the above problems, it is an object of the present invention to provide a high-efficiency skin bactericide which can prolong the sterilization time and the sustained bacteriostatic action, and can effectively penetrate the skin texture and thereby enhance the bactericidal effect.
為達上述目的，本發明之一種高效率皮膚殺菌劑包含一殺菌消毒劑、一緩釋劑以及一酸鹼調節劑。殺菌消毒劑包含乙醇。緩釋劑包含多元醇緩釋劑。酸鹼調節劑包含氫氧化鈉、磷酸、鹽酸、硝酸、三乙醇胺、檸檬酸或其組合。 To achieve the above object, a high-efficiency skin bactericide of the present invention comprises a bactericidal disinfectant, a sustained release agent, and an acid-base conditioner. The disinfectant contains ethanol. The sustained release agent comprises a polyol sustained release agent. The acid-base regulator comprises sodium hydroxide, phosphoric acid, hydrochloric acid, nitric acid, triethanolamine, citric acid or a combination thereof.
在一實施例中，乙醇水溶液之重量百分比為65%~75%。 In one embodiment, the aqueous ethanol solution is from 65% to 75% by weight.
在一實施例中，緩釋劑之重量百分比為1%~10%。 In one embodiment, the weight release agent is from 1% to 10% by weight.
在一實施例中，多元醇緩釋劑選自丙二醇、甘油(丙三醇)、1,3丁二醇及己六醇所構成之群組。 In one embodiment, the polyol sustained release agent is selected from the group consisting of propylene glycol, glycerol (glycerol), 1,3 butanediol, and hexahexaol.
在一實施例中，該酸鹼調節劑包含氫氧化鈉、磷酸、鹽酸、硝酸、三乙醇胺、檸檬酸或其組合。 In one embodiment, the acid-base regulator comprises sodium hydroxide, phosphoric acid, hydrochloric acid, nitric acid, triethanolamine, citric acid, or a combination thereof.
在一實施例中，高效率皮膚殺菌劑係為液狀。 In one embodiment, the high efficiency skin bactericide is in the form of a liquid.
在一實施例中，高效率皮膚殺菌劑更包含一成型劑，其包含高分子聚合物。高分子聚合物例如選自纖維素膠(Cellulose Gum)、亞拉伯膠(Gum Arabic/Gum Acacia)、甲基纖維素( Methylcellulose，MC)、果膠(Pectin)、三仙膠(Xanthan Gum)及卡波姆所構成之群組。 In one embodiment, the high efficiency skin germicide further comprises a forming agent comprising a high molecular weight polymer. The high molecular polymer is, for example, selected from the group consisting of Cellulose Gum, Gum Arabic/Gum Acacia, and Methylcellulose ( Group of Methylcellulose, MC), Pectin, Xanthan Gum and Carbomer.
在一實施例中，高效率皮膚殺菌劑係為膠狀。 In one embodiment, the high efficiency skin bactericide is in the form of a gel.
在一實施例中，高效率皮膚殺菌劑更包含一香精。 In one embodiment, the high efficiency skin bactericide further comprises a fragrance.
如上所述，本發明之高效率皮膚殺菌劑之緩釋劑可包含多元醇緩釋劑，其具有親脂性，使得殺菌劑可有效地深入皮膚紋理、並延長殺菌時間以及持續的抑菌作用，進而提升殺菌效果。換言之，以相同濃度的酒精而論，本發明的殺菌、抑菌效率相較習知技術來的高，且使用的頻率相較習知技術來的少。 As described above, the sustained release agent of the high-efficiency skin bactericide of the present invention may comprise a polyol sustained release agent which is lipophilic, so that the bactericide can effectively penetrate into the skin texture, prolong the sterilization time and maintain the bacteriostatic action. In turn, the sterilization effect is enhanced. In other words, the sterilization and bacteriostatic efficiency of the present invention are higher than those of the prior art in terms of the same concentration of alcohol, and the frequency of use is less than that of the prior art.
本發明較佳實施例之一種高效率皮膚殺菌劑包含一殺菌消毒劑、一緩釋劑以及一酸鹼調節劑。殺菌消毒劑包含一乙醇。緩釋劑包含多元醇緩釋劑。酸鹼調節劑包含氫氧化鈉、磷酸、鹽酸、硝酸、三乙醇胺、檸檬酸或其組合。 A high-efficiency skin bactericide according to a preferred embodiment of the present invention comprises a bactericidal disinfectant, a sustained release agent, and an acid-base conditioner. The disinfectant contains one ethanol. The sustained release agent comprises a polyol sustained release agent. The acid-base regulator comprises sodium hydroxide, phosphoric acid, hydrochloric acid, nitric acid, triethanolamine, citric acid or a combination thereof.
細部來說，乙醇水溶液之重量百分比例如為65%~75%。 In detail, the weight percentage of the aqueous ethanol solution is, for example, 65% to 75%.
緩釋劑之重量百分比可為1%~10%。 The weight release agent can be from 1% to 10% by weight.
多元醇緩釋劑可選自丙二醇、甘油(丙三醇)、1,3丁二醇、己六醇、及其他等效物所構成之群組。 The polyol sustained release agent may be selected from the group consisting of propylene glycol, glycerin (glycerol), 1,3 butanediol, hexahexaol, and other equivalents.
藉由加入酸鹼調節劑，可將高效率皮膚殺菌劑調整至pH值為5.5±0.5之微酸性，以符合人體之皮膚特質，俾達到溫和不刺激之效 果。 By adding an acid-base conditioner, the high-efficiency skin fungicide can be adjusted to a slightly acidic pH of 5.5±0.5 to conform to the skin characteristics of the human body, and the mildness and non-irritation effect can be achieved. fruit.
在不包含成型劑的情況下，高效率皮膚殺菌劑可為液狀，並可因此為噴霧式殺菌劑。 In the absence of a molding agent, the high efficiency skin bactericide can be liquid and can therefore be a spray bactericide.
另外，高效率皮膚殺菌劑可更包含一成型劑，其包含高分子聚合物。高分子聚合物之重量百分比可為0.1%~1.0%。高分子聚合物選自纖維素膠(Cellulose Gum)、亞拉伯膠(Gum Arabic/Gum Acacia)、甲基纖維素(Methylcellulose，MC)、果膠(Pectin)、三仙膠(Xanthan Gum)、卡波姆及其他等效物所構成之群組。 In addition, the high-efficiency skin germicide may further comprise a molding agent comprising a high molecular polymer. The weight percentage of the high molecular polymer may be from 0.1% to 1.0%. The high molecular polymer is selected from the group consisting of Cellulose Gum, Gum Arabic/Gum Acacia, Methylcellulose (MC), Pectin, Xanthan Gum, A group of carbomers and other equivalents.
在包含成型劑的情況下，高效率皮膚殺菌劑可為膠狀。 In the case of a molding agent, the high efficiency skin bactericide may be in the form of a gel.
此外，高效率皮膚殺菌劑可更包含一香精。香精的重量百分比可為0.1%~1.5%。藉由香精可使高效率皮膚殺菌劑具有芳香味道，進而吸引消費者親睞而提升產品競爭力。 In addition, high-efficiency skin fungicides may further comprise a fragrance. The percentage by weight of the fragrance can be from 0.1% to 1.5%. By using the essence, the high-efficiency skin fungicide has an aromatic taste, which in turn attracts consumers to enhance the competitiveness of the product.
以下舉例說明本發明之高效率皮膚殺菌劑之製造方法。 The method for producing the high-efficiency skin bactericide of the present invention will be exemplified below.
以膠狀之高效率皮膚殺菌劑來說，首先將水溶性高分子膠(例如纖維素膠(Cellulose Gum)、亞拉伯膠(Gum Arabic/Gum Acacia)、甲基纖維素(Methylcellulose，MC)、果膠(Pectin)、三仙膠(Xanthan Gum)、卡波姆)加入水中配置成0.1%~0.8%之成型劑，並以攪拌器於室溫下攪拌至溶液成均勻之膠狀物。然後，加入重量百分比為65%~75%的乙醇。接著，加入1~10%多元醇緩釋劑(例如丙二醇、甘油(丙三醇)、1,3丁二醇、己六醇、及其他等效物所構成之群組)攪拌。然後，加入酸鹼調節劑(例如氫氧化鈉、磷酸、鹽酸、硝酸、三乙醇胺、檸檬 酸)以將殺菌配方調整至pH值=5.5±0.5之微酸性。 In the case of colloidal high-efficiency skin fungicides, water-soluble polymer gels (such as Cellulose Gum, Gum Arabic/Gum Acacia, Methylcellulose, MC) are first used. Pectin, Xanthan Gum, and carbomer are added to the molding agent in a ratio of 0.1% to 0.8% in water, and stirred at room temperature with a stirrer until the solution becomes a uniform gel. Then, ethanol is added in an amount of 65% to 75% by weight. Next, a 1 to 10% polyol slow release agent (for example, a group consisting of propylene glycol, glycerin (glycerol), 1,3 butanediol, hexahexaol, and other equivalents) is added and stirred. Then, add an acid-base regulator (such as sodium hydroxide, phosphoric acid, hydrochloric acid, nitric acid, triethanolamine, lemon) Acid) to adjust the bactericidal formulation to a slightly acidic pH of pH = 5.5 ± 0.5.
以液狀之高效率皮膚殺菌劑來說，首先備取重量百分比為65%~75%的乙醇。接著，加入1~10%緩釋劑與乙醇攪拌混合。然後，加入酸鹼調節劑，以將殺菌配方調整至pH值=5.5±0.5之微酸性。 For liquid high-efficiency skin fungicides, first prepare ethanol in a weight percentage of 65% to 75%. Next, add 1~10% slow release agent and mix with ethanol. Then, an acid-base conditioner is added to adjust the bactericidal formulation to a slightly acidic pH of pH = 5.5 ± 0.5.
上述膠狀或液狀之高效率皮膚殺菌劑之製造方法皆可更包含加入香精，例如是0.1~1.5%香精。 The method for producing the above-mentioned colloidal or liquid high-efficiency skin bactericide may further comprise adding a fragrance, for example, 0.1 to 1.5% flavor.
綜上所述，本發明之高效率皮膚殺菌劑之緩釋劑可包含多元醇緩釋劑，其具有親脂性，使得高效率皮膚殺菌劑可有效地深入皮膚紋理、並延長殺菌時間以及持續的抑菌作用，進而提升殺菌效果。 In summary, the sustained release agent of the high-efficiency skin bactericide of the present invention may comprise a polyol sustained-release agent which is lipophilic, so that the high-efficiency skin bactericide can effectively penetrate the skin texture, prolong the sterilization time and last. Antibacterial effect, thereby enhancing the sterilization effect.
以上所述僅為舉例性，而非為限制性者。任何未脫離本發明之精神與範疇，而對其進行之等效修改或變更，均應包含於後附之申請專利範圍中。 The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims.
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| TWI577372B true TWI577372B (en) | 2017-04-11 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101658469B (en) * | 2009-09-10 | 2011-09-21 | 上海泛亚生命科技有限公司 | Cleaning-free hand sanitizer and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658469B (en) * | 2009-09-10 | 2011-09-21 | 上海泛亚生命科技有限公司 | Cleaning-free hand sanitizer and preparation thereof |
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| Title |
|---|
| "乾洗手消毒潔手溶液 75%", 網址：http://www.fda.gov.tw/MLMS/(S(rnuel0350ppgexfaw3kcck45))/H0001D.aspx?Type=Lic&LicId=03015564. "諾得乾洗手", 網址：https://tw.buy.yahoo.com/gdsale/gdsale.asp?gdid=2911823, 網頁日期：2010年11月13日. * |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201440757A (en) | 2014-11-01 |
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