TWI490493B - Centrifuge tube structure - Google Patents

Description

Centrifuge tube structure

This case relates to a centrifuge tube structure, in particular to a centrifuge tube structure for facilitating the extraction of a thin layer solution.

With the daily development of biomedical technology, the biomedical community has also been more and more complete research on human blood. Among them, all kinds of ingredients contained in the blood have their corresponding important functions. Therefore, if these components contained in the blood can be smoothly separated and used as medical adjuvant treatment, the current medical treatment will be greatly improved. Results. At present, a common way to separate various components in blood is to put a blood-filled test tube into a centrifuge to start, so that the blood in the test tube is centrifuged, and various components in the blood will be simply layered. .

As described above, after the centrifugation of the test tube by the centrifuge, at least the upper liquid, the middle liquid, and the lower liquid are usually formed in the test tube. The upper layer of liquid is mainly plasma, the lower layer of liquid is mainly red blood cells, and the middle layer of liquid is a blood clot yellow layer, mainly platelets, white blood cells and stem cells. Among them, the yellow blood clot is especially valuable because of its medical and commercial value. However, the yellow layer of the blood clot in the test tube is a thin layer. Because the thickness of the yellow layer of the blood clot is small, it is not easy to extract in an ordinary test tube, so it is necessary to be extra careful when extracting, otherwise it is easy to accidentally extract the upper liquid. Or the lower layer of liquid, so this step is indeed difficult for the extractor to operate.

For example, Taiwan Patent Publication No. 201124191 discloses a "biological device for extracting hematopoietic stem cells and mesenchymal stem cells from peripheral blood", the biological device comprising There is a body 11 and a top cover 10. The main body 11 has a neck portion 110, and the top cover 10 is movably advanced and retracted in the longitudinal direction of the main body 11, and the top cover 10 is rotated by a user so that the top cover 10 is along the main body 11. The portrait moves forward and backwards. However, the top cover 10 of the biological device has no need for movement. If the top cover 10 can be changed to a fixed type, even if the top cover 10 is integrally formed with the body 11, the structure and ease of manufacture will be simple. In addition, if the top cover 10 is fixed from the movable top cover 10 to the main body 11, it is more emphasized that the biological device is used once, so as to avoid costly people. The top cover 10 of the biological device is unscrewed, removed, washed and reused.

Furthermore, the biological device further includes a bottom cover 13, and the bottom cover 13 is rotated by an operator to advance and retreat the bottom cover 13 in the longitudinal direction of the body 11. The package further discloses a package portion 12 for closing the lower storage tank 120 of the body 11. The operator can rotate the bottom cover 13 to push the package portion 12, thereby reducing the volume of the lower storage tank 120. However, the operator's action of twisting the bottom cover by the finger causes the force component direction of the force application to be perpendicular to the longitudinal axis of the body 11 when the force is applied, so that the entire biological device is likely to cause left and right shaking, resulting in It is clear that the layered liquid, the intermediate liquid, and the lower liquid are layered to each other.

In view of the above, a centrifugal tube structure is provided, which not only provides a centrifugal tube structure which can easily extract a layered solution, but also provides a structure which is greatly simplified to facilitate production in manufacturing, and can further ensure the disposable use of the centrifuge tube structure, and When reducing the volume of the lower tank, the operator's direction of application is along a longitudinal axis to avoid sloshing the layered solution in the centrifuge tube structure, which is a current goal in the industry.

The main purpose of the present invention is to provide a centrifugal tube structure, which fixes the first blocking body to the first receiving groove to ensure that it is used once, and at the same time simplifies the structural design and is more convenient for manufacturing.

Another object of the present invention is to provide a centrifugal tube structure that receives an axial thrust and therefore does not easily shake left and right when the solution pushed into the centrifuge tube structure rises, so that the operator can extract the layered solution.

A preferred embodiment of the present invention is to provide a centrifuge tube structure, comprising: a tube body having a first accommodating groove, a second accommodating groove, and connecting the first accommodating groove and the second accommodating groove a necking portion; a first blocking body fixed to the first receiving groove and defining a fixed volume space together with the first receiving groove; and a second blocking body including a bottom cover And a piston portion, the bottom cover is fixed to the bottom end of the second accommodating groove, the piston portion closes the second accommodating groove; wherein the piston portion is received in the second accommodating groove, and the piston The portion and the second receiving groove define a variable volume space; wherein the neck portion defines a communication passage, and the communication passage communicates with the fixed volume space and the variable volume space.

In a preferred embodiment, the first receiving groove has a first opening, and the first blocking body is fixed to the first opening of the first receiving groove.

In a preferred embodiment, the first blocking body and the first receiving groove are integrally formed.

In a preferred embodiment, the first blocking body has an air hole corresponding to the necking portion; wherein the fixed volume space is connected through the air hole To the outside world.

In a preferred embodiment, the first blocking body further has a liquid inflow hole, and the liquid inflow hole is adjacent to the air hole.

In a preferred embodiment, the first blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the plug blocking the air hole has a jack, and a fine pin borrows The jack is inserted into the plug to enter the first receiving slot.

In a preferred embodiment, the necked portion has a cross-sectional area smaller than a cross-sectional area of the first receiving groove and a cross-sectional area of the second receiving groove.

In a preferred embodiment, the piston portion moves in the second accommodating groove to define the variable volume space together with the second accommodating groove; or the piston portion is accommodated in the second accommodating portion The piston portion is adapted to receive an external force to deform to define the variable volume space together with the second receiving groove.

In a preferred embodiment, the second blocking body further includes a push rod, and the central portion of the bottom cover is a hollow portion; wherein the push rod passes through the hollow portion and is connected to the piston portion. When the push rod receives an external force, the push rod is adapted to push the piston portion toward the neck portion.

A further preferred embodiment of the present invention is to provide a centrifuge tube structure, comprising: a tube body having a first accommodating groove, a second accommodating groove, and connecting the first accommodating groove and the second accommodating a first sealing body fixed to the first receiving groove and defining a fixed volume space together with the first receiving groove; and a second blocking body, and the first sealing body The two receiving slots collectively define a variable volume space; The neck portion defines a communication passage, and the communication passage communicates with the fixed volume space and the variable volume space.

In a preferred embodiment, the first blocking body and the first receiving groove are integrally formed.

In a preferred embodiment, the first receiving groove has a first opening, and the first blocking body is fixed to the first opening.

In a preferred embodiment, the first blocking body has an air hole corresponding to the necking portion; wherein the fixed volume space communicates with an outside through the air hole.

In a preferred embodiment, the first blocking body further has a fluid inflow hole liquid inflow hole, and the fluid inflow hole liquid inflow hole is adjacent to the air hole.

In a preferred embodiment, the first blocking body includes two plugs for blocking the fluid inflow hole and the air hole respectively; wherein the plug blocking the air hole has a jack, The fine needle is inserted into the insertion hole of the plug to enter the neck portion to enter the first receiving groove.

In a preferred embodiment, the necked portion has a cross-sectional area smaller than a cross-sectional area of the first receiving groove and a cross-sectional area of the second receiving groove.

In a preferred embodiment, the second blocking body includes a piston portion that is received in the second receiving groove and moves in the second receiving groove to match the second receiving portion. The second sealing body includes a piston portion, and the piston portion is received in the second receiving groove, and the piston portion is adapted to receive an external force to generate deformation. And defining the variable volume together with the second accommodating groove space.

In a preferred embodiment, the second blocking body further includes a bottom cover disposed at a bottom end of the second receiving groove, such that the piston portion is located between the bottom cover and the neck portion .

In a preferred embodiment, the bottom cover is movably disposed in the second receiving groove; wherein, when the bottom cover moves toward the neck portion, the bottom cover is adapted to push the piston portion together, so that The piston portion moves toward the neck portion.

In a preferred embodiment, a surface of the bottom cover is formed with a male thread, and a surface of the second receiving groove is formed with a female thread, and the male thread is adapted to cooperate with the female thread to make the bottom cover have an axial direction. When making a rotational motion, it is appropriate to simultaneously move along the axial direction.

In a preferred embodiment, the bottom cover has a negative structure, and the second receiving groove has a positive structure, and the negative structure is adapted to cooperate with the male structure, so that the bottom cover can be opposite to the second receiving groove. Make a slide.

In a preferred embodiment, the bottom cover is fixed to the second receiving groove, and the central portion of the bottom cover is a hollow portion.

In a preferred embodiment, the second blocking body further includes a push rod, wherein the push rod passes through the hollow portion and is coupled to the piston portion. When the push rod receives an external force, the push rod is adapted to The piston portion is pushed to move toward the neck portion.

In a preferred embodiment, the second blocking body further includes a push rod, wherein the push rod is coupled to the piston portion, and when the push rod receives an external force, the push rod is adapted to push the piston portion toward the The neck is moving.

Another preferred implementation concept of the present invention is to provide a centrifuge tube structure, which comprises And a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; wherein the first accommodating groove has a fixing means; a fixing cover body, the fixing means for contacting the first receiving groove, the fixing means fixing the fixing cover body to the first receiving groove; and a bottom cover disposed at the second The bottom end of the receiving groove.

In a preferred embodiment, the fixed cover body has a venting fluid inlet and outlet hole, and the position of the venting fluid inlet and outlet hole corresponds to the necking portion; wherein the fixed volume space is connected to an outside through the air hole. When a pumping device is received in the fluid inlet and outlet, one of the pumping devices partially enters the necking portion.

In a preferred embodiment, the piston portion is further disposed in the second receiving groove and movable in the second receiving groove.

In a preferred embodiment, the second receiving slot has a movable means, and the bottom cover is coupled to the movable means to enable the bottom cover to be movably disposed in the second receiving groove.

In a preferred embodiment, the piston portion is located between the bottom cover and the neck portion. When the bottom cover moves toward the neck portion, the bottom cover is adapted to push the piston portion together to make the piston The portion moves toward the neck portion.

In a preferred embodiment, the movable means of the second accommodating groove is a female thread of the second accommodating groove, and a surface of the bottom cover is formed with a male thread, and the male thread is adapted to the female thread. In cooperation, the bottom cover is adapted to move in the axial direction while rotating in an axial direction.

In a preferred embodiment, the movable means of the second accommodating groove is a negative structure of the second accommodating groove, and the bottom cover has a positive structure, and the positive structure is suitable for The negative structure cooperates to allow the bottom cover to slide relative to the second receiving groove.

In a preferred embodiment, a push rod is further included, wherein the push rod is coupled to the piston portion, and when the push rod receives an external force, the push rod is adapted to push the piston portion toward the neck portion.

In another preferred embodiment of the present invention, a centrifuge tube structure includes: a tube body having a first accommodating groove, a second accommodating groove, and a first accommodating groove and the second accommodating groove; a necking portion; a first blocking body fixed to the upper edge of the groove of the first receiving groove; and a second blocking body movably engaged under the groove of the second receiving groove The first blocking body, the first accommodating groove, the necking portion, the second accommodating groove and the second blocking body jointly define a volume space; Moving the second blocking body changes the capacity distribution state of one of the volume spaces.

In a preferred embodiment, the second blocking body includes a piston portion that is received in the second receiving groove and movable in the second receiving groove.

In a preferred embodiment, the second blocking body further includes a push rod connected to the piston portion; wherein when the push rod receives an axial thrust, the push rod is adapted to Pushing the piston portion in the longitudinal direction to move linearly in the direction of the neck portion to reduce the volume; or, when the push rod receives an axial pulling force, the push rod is adapted to be pulled along a longitudinal axis The piston portion linearly moves away from the neck portion to increase the volume.

In a preferred embodiment, one end of the push rod is coupled to the piston portion to be integrally formed with the piston portion; or, one end of the push rod is hooked to the piston portion.

In a preferred embodiment, the second blocking body further includes a bottom cover, and the bottom cover is movably disposed at a lower edge of the groove of the second receiving groove; wherein the bottom cover is necked toward the neck When the portion is moved, the bottom cover is adapted to push the piston portion together to move the piston portion toward the neck portion to reduce the volume; or, when the bottom cover moves away from the neck portion The bottom cover is adapted to pull the piston portion together to move the piston portion away from the neck portion to increase the volume.

A further preferred embodiment of the present invention is to provide a centrifuge tube structure, comprising: a tube body having a first accommodating groove, a second accommodating groove, and connecting the first accommodating groove and the second accommodating a first necking portion of the slot; a first blocking body covering the first receiving groove; a second blocking body comprising a bottom cover and a piston portion, the bottom cover being fixed to the second receiving groove The bottom end of the piston portion closes the second receiving groove, and the piston portion is movable in the second receiving groove.

In a preferred embodiment, the method further includes a push rod, wherein the push rod is coupled to the piston portion, and the push rod is adapted to push the piston portion along a longitudinal axis when the push rod receives an axial thrust , moving linearly in the direction of the neck portion.

In a preferred embodiment, the central portion of the bottom cover is a hollow portion.

In a preferred embodiment, the method further includes a push rod, wherein the push rod passes through the hollow portion and is coupled to the piston portion, and the push rod is adapted to push the piston when the push rod receives an axial thrust The portion moves linearly in the direction of the neck portion along a longitudinal axis.

In a preferred embodiment, the first blocking body is fixed to the first receiving groove to define a fixed volume space together with the first receiving groove; or the first blocking body is movable Provided in the first accommodating groove to define together with the first accommodating groove A variable volume space.

In a preferred embodiment, the first blocking body has an air hole corresponding to the necking portion; wherein the fixed volume space or the variable volume space is connected to the air hole through the air hole external.

In a preferred embodiment, the first blocking body further has a liquid inflow hole, and the liquid inflow hole is adjacent to the air hole.

In a preferred embodiment, the first blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the plug blocking the air hole has a jack, and a fine pin borrows The jack is inserted into the plug to enter the first receiving slot.

In a preferred embodiment, the necked portion has a cross-sectional area that is smaller than a cross-sectional area of the first receiving groove and a cross-sectional area of the second receiving groove.

A further preferred embodiment of the present invention is to provide a centrifuge tube structure, comprising: a tube body having a first accommodating groove, a second accommodating groove, and connecting the first accommodating groove and the second accommodating a first necking portion of the groove; a first blocking body covering the first receiving groove; a piston portion closing the second receiving groove, and the piston portion is movable in the second receiving groove; And a push rod is connected to the piston portion. When the push rod is pushed by an external force, the piston portion is correspondingly pushed to move linearly in a longitudinal direction toward the neck portion.

In a preferred embodiment, the external force received by the push rod is an axial top thrust to urge the piston portion to move linearly in a longitudinal direction toward the neck portion.

In a preferred embodiment, a bottom cover is further fixed to the second receiving slot. The bottom end is such that the piston portion is located between the bottom cover and the neck portion.

In a preferred embodiment, the first blocking body has an air hole corresponding to the necking portion; wherein the fixed volume space or the variable volume space is connected to the air hole through the air hole external.

A further preferred embodiment of the present invention is to provide a centrifuge tube structure, comprising: a tube body having a first accommodating groove, a second accommodating groove, and connecting the first accommodating groove and the second accommodating a necking portion of the slot; a first blocking body covering the first receiving groove; and a movable member closing the second receiving groove, and the movable member is adapted to receive an axial thrust The movable member is linearly moved in a longitudinal direction toward the neck portion.

In a preferred embodiment, the movable member includes a piston portion that together with the second receiving groove defines a variable volume space.

In a preferred embodiment, the movable member further includes a push rod connected to the piston portion; wherein the push rod is adapted to receive the axial top thrust to push the piston portion along the axial direction The neck portion moves to reduce the variable volume space.

In a preferred embodiment, the first blocking body is fixed to the first receiving groove to define a fixed volume space together with the first receiving groove; or the first blocking body is movable The first accommodating groove is disposed to define another variable volume space together with the first accommodating groove.

In a preferred embodiment, the first blocking body has an air hole corresponding to the necking portion; wherein the fixed volume space or the variable volume space is connected to the air hole through the air hole external.

A further preferred embodiment of the present invention is to provide a centrifuge tube structure, comprising: a tube body having a first accommodating groove, a second accommodating groove, and the first accommodating groove and the second accommodating a necking portion of the groove; a first blocking body covering the upper edge of the groove body of the first receiving groove; and a movable member closing the lower edge of the groove body of the second receiving groove; wherein The first resisting body, the first accommodating groove, the necking portion, the second accommodating groove and the movable member define a total volume space, and the movable member is adapted to receive an axial top The thrust is such that the movable member linearly moves in a longitudinal direction toward the neck portion and changes a capacity distribution state of the total volume space.

In a preferred embodiment, the movable member includes a piston portion that is received in the second receiving groove and movable in the second receiving groove.

In a preferred embodiment, the movable member further includes a push rod connected to the piston portion; wherein the push rod is adapted to be along a longitudinal axis when the push rod receives an axial thrust Pushing the piston portion to move linearly in the direction of the neck portion to reduce the total volume space; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston along a longitudinal axis The portion moves linearly away from the neck portion to increase the total volume.

In a preferred embodiment, one end of the push rod is coupled to the piston portion to be integrally formed with the piston portion; or, one end of the push rod is hooked to the piston portion.

In a preferred embodiment, the movable member further includes a bottom cover movably disposed at a lower edge of the groove of the second receiving groove; wherein, when the bottom cover moves toward the neck portion, The bottom cover is adapted to push the piston portion together to move the piston portion toward the neck portion to reduce the total volume space; or, when the bottom cover moves away from the neck portion, the bottom cover The cover can pull the piston portion together to make the piston portion face away The direction of the neck is moved to increase the total volume.

The following examples are intended to illustrate the contents of the present invention and are not intended to limit the present case. It should be noted that in the following embodiments and drawings, elements not related to the present invention have been omitted and are not shown.

The main inventive spirit of the present invention discloses a centrifuge tube structure for accommodating blood to be separated and doped with a small amount of anticoagulant to prevent blood from solidifying during operation. After the operator seals the blood to the structure of the centrifuge tube, the centrifuge tube structure containing the blood is placed in a general centrifuge to perform the centrifugation. The principle is that, due to the different specific gravity of the various components contained in the blood, the centrifugal action is performed using a centrifuge tube structure and a centrifuge, and after standing for a period of time, the blood in the centrifuge tube structure is clearly layered into three layers. The solution, the upper layer solution is a plasma layer, the middle layer solution is a buffy yellow layer, and the lower layer solution is a red blood cell layer. Among them, the yellow layer of blood clot sandwiched between the plasma layer and the red blood cell layer is rich in a large amount of growth factors, which helps to repair the function of the aging tissue, promotes metabolism and regenerates the skin, and is often applied to the medical cosmetic treatment process. Make it rich in commercial value. However, since the yellow layer of the blood clot is only a thin layer, the operator is more difficult to extract, and the centrifuge tube structure of the present case is a centrifuge tube structure designed to facilitate the extraction of a thin layer solution (in this case, for facilitating the extraction of the yellow layer of the blood clot). .

First, please refer to FIG. 2 to FIG. 4 , FIG. 2 and FIG. 3 are schematic cross-sectional views of the blood in the centrifuge tube structure of the first embodiment of the present invention before being pushed up and after being lifted, FIG. 4 is the present case. A schematic cross-sectional view of a second embodiment of a centrifuge tube structure. this The centrifuge tube structure includes a tube body 2 having a first accommodating groove 20, a second accommodating groove 22 and a necking portion 21, and the necking portion 21 is connected to the first accommodating groove 20 and The second receiving groove 22 is provided. Wherein, the cross-sectional area of the neck portion 21 is smaller than the cross-sectional area of the first accommodating groove 20 and the cross-sectional area of the second accommodating groove 22, that is, the neck portion 21 of the centrifuge tube structure is tapered, and the centrifuge tube structure is made. The overall shape presents an hourglass shape.

Furthermore, the centrifugal tube structure further includes a first blocking body 3 and a second blocking body 4. In the embodiment, the first blocking body 3 is fixed and limited to the groove of the first receiving groove 20. The upper edge is incapable of moving, and the second blocking body 4 is movably coupled to the lower edge of the groove of the second receiving groove 22. By this arrangement, the first blocking body 3, the first accommodating groove 20, the necking portion 21, the second accommodating groove 22 and the second blocking body 4 jointly define a total volume space 5, and By moving the second blocking body 4, the capacity distribution state of one of the total volume spaces 5 can be changed. In other words, since the first blocking body 3 is fixed to the first accommodating groove 20, the first blocking body 3 and the first accommodating groove 20 together define a fixed volume space 200; similarly, The second blocking body 4 is movably disposed in the second accommodating groove 22, so that the second blocking body 4 and the second accommodating groove 22 jointly define a variable volume space 220; and by the necking portion 21 One of the communication passages 210 is defined to communicate the fixed volume space 200 with the variable volume space 220. In other words, the total volume space 5 is formed by the fixed volume space 200, the communication passage 210, and the variable volume space 220.

In this case, in order to fix the first blocking body 3 to the first receiving groove 20, the first blocking body 3 and the first receiving groove 20 may be fixed in the first blocking body 3. And the first accommodating groove 20 is integrally formed at the time of forming (see FIG. 2 and As shown in FIG. 3, or as shown in FIG. 4, the first receiving groove 20 can have a fixing means 205, and the first blocking body 3 is a fixing cover 35, and the fixing cover 35 is fastened to the first The fixing means 205 of the receiving groove 20 is fixed to the first receiving groove 20 by the fixing means 205. The first blocking body 3 can be fixed to the first opening portion 201 of the first receiving groove 20 by any fixing manner such as snapping, inlaying, and fixing. With this arrangement, it is intended to prevent the first blocking body 3 from being easily removed from the first accommodating groove 20, and the possibility of repeated use after cleaning the centrifuge tube structure by the unintentional person may be carried out in the blood. Infectious bacteria and viruses, therefore, it is absolutely necessary to ensure that the centrifuge tube structure is only for one-time use.

Furthermore, please continue to refer to FIG. 2 and FIG. 3, the centrifugal tube structure is used in an upright position, wherein the first blocking body 3 is located above and the second blocking body 4 is located below. Since the blood system is placed in the total volume space 5, if the blood has completed the separation step, a three-layer layered solution is present in the total volume space 5. At this time, if the second blocking body 4 is pushed to move toward the necking portion 21, the total volume space 5 can be reduced, and the solution of each layer can be moved up; otherwise, if the second blocking body 4 is pulled away from the necking portion Moving in the 21 direction, the total volume space 5 can be increased to lower the solution of each layer. Wherein, since the volume of each layer solution is kept fixed, the height of each layer solution can be adjusted by operating the second blocking body 4, so that any layer of each layer solution is adjusted to be located at the necking portion 21, and is subjected to the necking portion. The effect of the reduction in the cross-sectional area of 21 increases the thickness of the solution of the layer, and allows the operator to greatly increase the ease of performing the extraction of the solution.

Please continue to refer to Figure 2 and Figure 3. Wherein, the first blocking body 3 has an air hole 202 and a liquid inflow hole 203, in order to avoid performing centrifugation when performing centrifugation The blood in the structure may overflow from the air hole 202 or the liquid inflow hole 203. Therefore, the first blocking body 3 includes two plugs 204, 204', and when performing the centrifugal action, the two plugs 204, 204' may be respectively blocked. A liquid on the resist 3 flows into the hole 203 and the air hole 202. Among them, the plug 204' has a through hole 204'a for inserting a thin needle 6. The position of the air hole 202 corresponds to the neck portion 21, and when the thin needle 6 is received in the through hole 204'a, a portion of the thin needle 6 can enter the first receiving groove to take the layer in the total volume space 5. Solution. Of course, the user can take any layer in the layered solution according to actual demand conditions, and is not limited herein.

Further, the air hole 202 is adjacent to the liquid inflow hole 203 for a liquid to be injected from the outside, and the total volume space 5 is gas-connected to the outside through the air hole 202. The purpose of providing the air holes 202 is that when blood is injected into the total volume space 5, part of the space in the total volume space 5 is occupied by the blood, so that the gas originally contained in the total volume space 5 can be discharged to the outside through the air holes 202.

Referring to FIG. 2 to FIG. 4 , the second blocking body 4 includes a piston portion 41 . The piston portion 41 is received in the second receiving groove 22 and movable in the second receiving groove 22 . Here, the user can change the capacity distribution state of one of the total volume spaces 5 by moving the piston portion 41. For example, the user can push the piston portion 41 to reduce the total volume space 5 or pull the piston portion 41 to increase the total volume space 5. In addition, by applying force to the piston portion 41 to deform the piston portion 41, the total volume space 5 can also be reduced or increased, which is also a possible embodiment of the piston portion 41 of the centrifugal tube structure of the present invention.

Please refer to FIG. 5 to FIG. 6 , which are cross-sectional views of the third and fourth embodiments of the centrifugal tube structure of the present invention. To be explained here, in order to indicate the first blocking body as much as possible 3, in the case of various possibilities, FIG. 5 is integrally formed with the first blocking body 3 and the first receiving groove 20, and FIG. 6 is covered with the first blocking body 3 on the first receiving groove 20. Of course, this is only an enumeration of the relationship between the first blocking body 3 and the first receiving groove 20, and thus does not limit other possible fixing manners of the first blocking body 3 and the first receiving groove 20.

As shown in FIG. 5, it is an embodiment in which the push rod 42 is used to push the piston portion 41. In one embodiment, the second blocking body 4 further includes a push rod 42 connected to the piston portion 41, and the axial direction of the push rod 42 is parallel to one longitudinal axis of the tubular body 2, preferably a push rod. The axial direction of 42 is the longitudinal axis of the tubular body 2. Therefore, when the push rod 42 receives an axial thrust, the push rod 42 is adapted to push the piston portion 41 along the longitudinal direction to linearly move the piston portion 41 toward the neck portion 21, thereby reducing the total volume space. 5. Similarly, when the push rod 42 receives an axial pulling force, the push rod 42 is adapted to pull the piston portion 41 in the longitudinal direction and move linearly away from the neck portion 21, thereby increasing the total volume space 5. It should be noted that the push rod 42 and the piston portion 41 may be connected in such a manner that one end of the push rod 42 is integrally formed with the piston portion 41; or, one end of the push rod 42 is hooked on the piston portion 41, and thus, The up-down or down-shift of the piston portion 41 can be controlled by manipulating the push rod 42. This is a possible implementation and is not limited herein.

Among them, the operator can change the capacity distribution state of one of the total volume spaces 5 by moving the piston portion 41. For example, the operator can push the piston portion 41 to reduce the total volume space 5 or pull the piston portion 41 to increase the total volume space 5. In addition to this, the operator can also reduce the total volume space 5 by applying a force to the piston portion 41 to deform the piston portion 41, which is also a possible implementation.

As shown in FIG. 6, it is an embodiment in which a bottom cover 43 is additionally provided in addition to the use of the push rod 42 to push the piston portion 41. The second blocking body 4 further includes a bottom cover 43 fixed to the lower edge of the groove of the second receiving groove 22 for limiting the piston portion 41 to be located at the bottom cover 43 and the neck. Between the constrictions 21 . In the present embodiment, the central portion of the bottom cover 43 is a hollow portion 430 for the push rod 42 to pass through the hollow portion 430 and is coupled to the piston portion 41. In this way, when the push rod 42 receives an external force, the push rod 42 is adapted to move the piston portion 41 toward the neck portion 21 and/or pull the piston portion 41 to move away from the neck portion 21, thereby adjusting the inside of the centrifuge tube structure. In the case where the stratified blood is displaced upward and downward, the actuation mode is similar to that of the previous embodiment; at the same time, the present embodiment can limit the possibility that the piston portion 41 is excessively pulled away from the second accommodating groove 22 by the bottom cover 43.

7 and 8, which are schematic cross-sectional views of the fifth and sixth embodiments of the centrifugal tube structure of the present invention, which are embodiments in which the bottom cover is used to push the piston portion 41. The second blocking body 4 further includes a bottom cover 44, 45, and the bottom cover 44, 45 is movably disposed at the lower edge of the groove of the second receiving groove 22, so that the piston portion 41 is located at the bottom cover. 44, 45 and between the necking portion 21. The bottom covers 44 and 45 are connected to the piston portion 41. The bottom covers 44 and 45 are connected to the piston portion 41 in such a manner as to be integrally formed, snapped to each other, or abutted against each other, which is not limited thereto. Wherein, when the bottom covers 44, 45 move toward the neck portion 21, the bottom covers 44, 45 push the piston portion 41 to move the piston portion 41 toward the neck portion 21, thereby reducing the total volume space 5; similarly, When the bottom covers 44, 45 are moved away from the neck portion 21, the bottom covers 44, 45 are adapted to pull the piston portion 41 to move the piston portion 41 away from the neck portion 21, thereby increasing the total volume. Space 5.

Continuing to refer to FIG. 7 and FIG. 8 , further, as shown in FIG. 7 , the mutual movement between the bottom cover and the second accommodating groove 22 may be such that a surface of the bottom cover 44 is formed with a male thread 221 , and The surface of the second receiving groove 22 is formed with a female thread 222. The male thread 221 is adapted to cooperate with the female thread 222. Therefore, when the bottom cover 44 receives the force applied in all directions, the bottom cover 44 is adapted to rotate in the axial direction. And move along the axis. In addition, the mutual movement between the bottom cover and the second receiving groove 22 can also move in other ways.

As shown in FIG. 8, the bottom cover 45 is a lower edge of the trough body that is movably disposed in the second accommodating groove 22. Wherein, the bottom cover 45 can receive an axial thrust and move along the longitudinal axis toward the neck portion 21, and push the piston portion 41 by the bottom cover 45 to move the piston portion 41 toward the neck portion 21 to reduce The total volume 5; or, when the bottom cover 45 receives an axial pulling force to move away from the neck portion 21 in the longitudinal direction, the bottom cover 45 is adapted to pull the piston portion 41 together, so that the piston portion 41 faces away from the neck The direction of the constricted portion 21 is moved to increase the total volume space 5. In detail, the bottom cover 45 has a negative structure 223, and the second receiving groove 22 has a positive structure 224. The negative structure 223 is adapted to cooperate with the male structure 224, so that the bottom cover 45 can be made opposite to the second receiving groove 22. slide.

As described above, one of the female thread 220 of the second accommodating groove 22 and the negative structure 224 of the second accommodating groove 22 are one of the possible activities of the second accommodating groove 22 of the present case, and the like. limit.

Please refer to FIG. 9 , which is a schematic cross-sectional view of a seventh embodiment of the centrifugal tube structure of the present invention. In the embodiment, the first blocking body 3 of the centrifugal tube structure is a fixing cover 35, and is fixed to the fixing means 205 of the first receiving groove 20, and the fixing cover 35 is fixed to the fixing cover 35 by the fixing means 205. The first receiving groove 20 is provided. In addition, the second blocking body 4 further includes a push rod 42 coupled to the piston portion 41, and the axial direction of the push rod 42 is parallel to the longitudinal axis of the centrifuge tube structure for the user to push.

Please refer to FIG. 10 , which is a schematic cross-sectional view of an eighth embodiment of the centrifugal tube structure of the present invention. In the embodiment, the first blocking body 3 of the centrifugal tube structure is a fixing cover 35, and is fixed to the fixing means 205 of the first receiving groove 20, and the fixing cover 35 is fixed to the fixing cover 35 by the fixing means 205. The first receiving groove 20 is provided. In addition, the second blocking body 4 further includes a bottom cover 44 for receiving the user's urging force along the line direction, so that the bottom cover 45 is rotated in the axial direction and moves along the axial direction. Further, the piston portion 41 is pushed to move toward the neck portion 21.

In summary, the centrifuge tube structure disclosed in the present invention makes it easier for the operator to extract the layered solution by designing a neck portion having a narrow cross-sectional area. The centrifugal tube structure of the present invention can be designed such that the first blocking body and the first receiving groove are fixed to each other and cannot be relatively moved or separated to ensure that the centrifuge tube structure disclosed in the present invention is disposable and simplified at the same time. The structural design of the centrifuge tube structure makes it easier to mass-produce in manufacturing. In addition, the centrifugal tube structure of the present invention can also be designed such that the bottom cover is fixedly disposed at the lower edge of the trough body of the second accommodating groove, so that the piston portion is limited. Wherein, the movable member is designed to receive an axial force to push the piston portion, so that when the operator performs the extraction action, the force can be prevented from being applied in other directions, which may result in a component force. It is applied to the structure of the centrifuge tube to cause the structure of the centrifuge tube to shake side to side.

However, the above is only the preferred embodiment of the present case, and it is not intended to limit the scope of patent protection in this case. Therefore, the equivalent changes in the case of the present specification and the contents of the drawings are all included in the scope of protection of the case. Combined with Chen Ming.

10‧‧‧Top cover

11‧‧‧Ontology

110‧‧‧ Bottleneck

120‧‧‧ Lower storage tank

2‧‧‧ tube body

20‧‧‧First accommodating slot

200‧‧‧Fixed volume space

201‧‧‧First opening

202‧‧‧Liquid inflow hole

203‧‧‧ stomata

204‧‧ ‧ embolization

204’‧‧‧ embolization

204’a‧‧‧through hole

205‧‧‧Fixed means

21‧‧‧neck

210‧‧‧Connected channel

22‧‧‧Second accommodating slot

220‧‧‧Variable volume space

221‧‧‧ male thread

222‧‧‧ female thread

3‧‧‧First blocking body

35‧‧‧Fixed cover

4‧‧‧second blocking body

41‧‧‧Piston Department

42‧‧‧Put

43‧‧‧ bottom cover

430‧‧‧镂空部

44‧‧‧ bottom cover

45‧‧‧ bottom cover

5‧‧‧ total volume space

6‧‧‧ fine needle

Figure 1 is a schematic cross-sectional view of a conventional biological device.

2 is a schematic cross-sectional view of the first embodiment of the centrifuge tube structure of the present invention before the blood has been pushed up.

Fig. 3 is a schematic cross-sectional view showing the first embodiment of the centrifuge tube structure of the present invention after the blood has been pushed up and inserted into the fine needle.

Fig. 4 is a schematic cross-sectional view showing a second embodiment of the centrifugal tube structure of the present invention.

Fig. 5 is a schematic cross-sectional view showing a third embodiment of the centrifugal tube structure of the present invention.

Fig. 6 is a schematic cross-sectional view showing a fourth embodiment of the centrifugal tube structure of the present invention.

Fig. 7 is a schematic cross-sectional view showing a fifth embodiment of the centrifugal tube structure of the present invention.

Fig. 8 is a schematic cross-sectional view showing a sixth embodiment of the centrifugal tube structure of the present invention.

Fig. 9 is a schematic cross-sectional view showing a seventh embodiment of the centrifugal tube structure of the present invention.

Figure 10 is a cross-sectional view showing the eighth embodiment of the centrifugal tube structure of the present invention.

2‧‧‧ tube body

20‧‧‧First accommodating slot

200‧‧‧Fixed volume space

204‧‧ ‧ embolization

204’‧‧‧ embolization

204’a‧‧‧through hole

21‧‧‧neck

210‧‧‧Connected channel

22‧‧‧Second accommodating slot

220‧‧‧Variable volume space

3‧‧‧First blocking body

4‧‧‧second blocking body

41‧‧‧Piston Department

5‧‧‧ total volume space

6‧‧‧ fine needle

Claims (27)

A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; The first blocking groove is fixed to the first accommodating groove and defines a fixed volume space together with the first accommodating groove; wherein the first blocking body and the first accommodating groove are integrally formed; The second blocking body includes a bottom cover and a piston portion, the bottom cover is fixed to the bottom end of the second receiving groove, and the piston portion closes the second receiving groove; wherein the piston portion is accommodated in the first portion The second receiving portion defines a variable volume space together with the second receiving groove; wherein the necking portion defines a communication passage, and the communication passage communicates with the fixed volume space and the Variable volume space. The centrifuge tube structure of claim 1, wherein the first blocking body has an air hole and a liquid inflow hole, and the position of the air hole corresponds to the necking portion, and the fixed volume space passes through the air hole Connected to an outside, the liquid inflow hole is adjacent to the air hole; wherein the first blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the plug is blocked by the air hole The utility model has a jack, and a fine pin is inserted into the jack of the plug to enter the first receiving slot. The centrifuge tube structure of claim 1, wherein the piston portion moves in the second accommodating groove to define the variable volume space together with the second accommodating groove; or the piston portion The piston portion is adapted to receive an external force to deform the piston portion to define the variable volume together with the second receiving groove The second blocking body further includes a push rod, and a central portion of the bottom cover is a hollow portion; the push rod passes through the hollow portion and is connected to the piston portion, and the push rod receives a When the external force is applied, the push rod is adapted to push the piston portion toward the neck portion; wherein the neck portion has a cross-sectional area smaller than a cross-sectional area of the first receiving groove and a cross-section of the second receiving groove area. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; The first blocking groove is fixed to the first accommodating groove and defines a fixed volume space together with the first accommodating groove; wherein the first blocking body and the first accommodating groove are integrally formed; The second blocking body defines a variable volume space together with the second receiving groove; wherein the necking portion defines a communication channel, and the communication channel communicates with the fixed volume space and the variable volume space. The centrifuge tube structure of claim 4, wherein the first blocking body has an air hole and a liquid inflow hole, the position of the air hole corresponding to the necking portion, and the fixed volume space is The air hole is connected to the outside, and the liquid inflow hole is adjacent to the air hole; wherein the first blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the air hole is blocked The plug has a jack, and a thin pin is inserted into the jack of the plug to enter the first receiving slot. The centrifugal tube structure of claim 5, wherein the second blocking body comprises a piston portion, the piston portion is received in the second receiving groove, and moves in the second receiving groove And defining the variable volume space together with the second accommodating groove; Or wherein the second blocking body comprises a piston portion, the piston portion is received in the second receiving groove, and the piston portion is adapted to receive an external force to deform to jointly define with the second receiving groove Out of this variable volume space. The centrifuge tube structure of claim 6, wherein the second blocking body further comprises a bottom cover, wherein the bottom cover is disposed at a bottom end of the second receiving groove, so that the piston portion is located at the bottom cover And the bottom cover is movably disposed in the second receiving groove, and the bottom cover is adapted to push the piston portion together when the bottom cover moves toward the neck portion. The piston portion is moved toward the neck portion. The centrifugal tube structure according to claim 7, wherein a surface of the bottom cover is formed with a male thread, and a surface of the second receiving groove is formed with a female thread, and the male thread is adapted to cooperate with the female thread. The bottom cover is adapted to move along the axial direction while rotating in an axial direction; or the bottom cover has a negative structure, and the second receiving groove has a positive structure, and the negative structure is suitable for The male structure cooperates to allow the bottom cover to slide relative to the second receiving groove. The centrifuge tube structure of claim 7, wherein the bottom cover is fixed to the second receiving groove, and the central portion of the bottom cover is a hollow portion, and the second blocking body further comprises a push rod. The push rod passes through the hollow portion and is connected to the piston portion. When the push rod receives an external force, the push rod is adapted to push the piston portion to move toward the neck portion; or the second blocking body The utility model further comprises a push rod, wherein the push rod is connected to the piston portion, and when the push rod receives an external force, the push rod is adapted to push the piston portion to move toward the neck portion. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; a fixing cover body integrally formed with the first receiving groove to fix the fixing cover body to the first receiving groove; and a bottom cover disposed at a bottom end of the second receiving groove. The centrifugal tube structure of claim 10, further comprising a piston portion, the piston portion being received in the second receiving groove and movable in the second receiving groove; wherein the The two receiving slots have a movable means, and the bottom cover is coupled to the movable means to enable the bottom cover to be movably disposed in the second receiving groove. The centrifugal tube structure according to claim 11, wherein the piston portion is located between the bottom cover and the neck portion, and the bottom cover is adapted to be pushed together when the bottom cover moves toward the neck portion The piston portion moves the piston portion toward the neck portion. The centrifugal tube structure of claim 12, wherein the movable means of the second receiving groove is a female thread of the second receiving groove, and a surface of the bottom cover is formed with a male thread. The thread is adapted to cooperate with the female thread to make the bottom cover move in an axial direction while rotating in an axial direction; or the movable means of the second receiving groove is a second capacity One of the negative structures of the groove, the bottom cover has a positive structure, and the positive structure is adapted to cooperate with the negative structure, so that the bottom cover can slide relative to the second receiving groove; wherein the centrifuge tube structure further comprises a push rod, wherein the push rod is coupled to the piston portion, and when the push rod receives an external force, the push rod is adapted to push the piston portion toward the neck portion. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; a blocking body fixed to the upper edge of the groove of the first receiving groove; wherein the first blocking body is integrally formed with the first receiving groove; a second blocking body is movably coupled to the lower edge of the second receiving groove; wherein the first blocking body, the first receiving groove, the necking portion, and the second receiving groove are Between the second blocking bodies, a volume space is defined together; and by moving the second blocking body, a capacity distribution state of the volume space can be changed. The centrifuge tube structure of claim 14, wherein the second blocking body further comprises a piston portion and a push rod, the piston portion is received in the second receiving groove, and The accommodating groove moves, and the push rod is connected to the piston portion; wherein, when the push rod receives an axial top thrust, the push rod is adapted to push the piston portion along a longitudinal axis toward the neck The direction of the constriction is linearly moved to reduce the volume; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston portion along a longitudinal axis, away from the neck portion The direction is linearly moved to increase the volume; wherein one end of the push rod is coupled to the piston portion to be integrally formed with the piston portion; or, one end of the push rod is hooked to the piston portion. The centrifuge tube structure of claim 15, wherein the second blocking body further comprises a bottom cover, wherein the bottom cover is movably disposed at a lower edge of the trough body of the second receiving groove; When the bottom cover is moved toward the neck portion, the bottom cover is adapted to push the piston portion together to move the piston portion toward the neck portion to reduce the volume; or, the bottom cover faces away from the When the direction of the neck portion moves, the bottom cover is adapted to pull the piston portion together to move the piston portion away from the neck portion to increase the volume. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; a first blocking groove; the first blocking body and the The first receiving groove is integrally formed; and a second blocking body includes a bottom cover and a piston portion, the bottom cover is fixed to the bottom end of the second receiving groove, and the piston portion closes the second receiving groove And the piston portion is movable in the second receiving groove. The centrifugal tube structure according to claim 17, further comprising a push rod, wherein the push rod is coupled to the piston portion, and the push rod is adapted to push the piston when the push rod receives an axial thrust The portion moves linearly in a direction perpendicular to the neck portion; or the centrifugal tube structure further includes a push rod, wherein the push rod passes through a hollow portion of the central portion of the bottom cover and is connected thereto The piston portion is adapted to urge the piston portion to move linearly in a longitudinal direction toward the neck portion when the push rod receives an axial thrust. The centrifugal tube structure of claim 18, wherein the first blocking body is fixed to the first receiving groove to define a fixed volume space together with the first receiving groove; or a resistor body is movably disposed in the first accommodating groove to define a variable volume space together with the first accommodating groove; wherein the first blocking body has a vent hole and a liquid inflow hole The position of the air hole corresponds to the neck portion, and the fixed volume space or the variable volume space is connected to the outside through the air hole, and the liquid inflow hole is adjacent to the air hole; wherein the first seal The blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the plug blocking the air hole has a jack, and a thin pin is inserted through the jack of the plug to Enter the first receiving slot. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; a first blocking body covering the first receiving groove; a piston portion closing the second receiving groove, wherein the piston portion is movable in the second receiving groove; and a push rod connected to the The piston portion, when the push rod is pushed by an external force, is adapted to correspondingly push the piston portion to move linearly along a longitudinal direction toward the neck portion; wherein the direction of the external force is parallel to the longitudinal axis . The centrifuge tube structure of claim 20, further comprising a bottom cover fixed to the bottom end of the second receiving groove, wherein the piston portion is located between the bottom cover and the neck portion; The external force received by the push rod is an axial top thrust to urge the piston portion to move linearly in a longitudinal direction toward the neck portion. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; a blocking body covering the first receiving groove; and a movable member closing the second receiving groove, and the movable member is adapted to receive an axial thrust so that the movable member faces along a longitudinal axis The direction of the neck portion is linearly moved; wherein one of the axial jack thrusts is axially parallel to the longitudinal axis. The centrifugal tube structure of claim 22, wherein the movable member comprises a piston portion and a push rod, the piston portion and the second receiving groove jointly define a variable volume space, the push rod is connected to the a piston portion; wherein the push rod is adapted to receive the axial top thrust to urge the piston portion to move toward the neck portion along the axial direction to reduce the variable volume space. The centrifugal tube structure of claim 23, wherein the first blocking body is fixed to the first receiving groove to define a fixed capacity together with the first receiving groove. Or the first blocking body is movably disposed in the first receiving groove to define another variable volume space together with the first receiving groove; wherein the first blocking body is The air hole has a position corresponding to the neck portion; wherein the fixed volume space or the variable volume space communicates to an outside through the air hole. A centrifuge tube structure comprising: a tube body having a first accommodating groove, a second accommodating groove, and a necking portion connecting the first accommodating groove and the second accommodating groove; a blocking body covering the upper edge of the groove body of the first accommodating groove; and a movable member closing the lower edge of the groove body of the second accommodating groove; wherein, the first blocking body, the first accommodating body Between the groove, the neck portion, the second receiving groove and the movable member, a total volume space is defined, and the movable member is adapted to receive an axial top thrust so that the movable member is along a longitudinal axis Towardly move in a direction toward the neck portion and change a capacity distribution state of the total volume space; wherein one of the axial tip thrusts is axially parallel to the longitudinal axis. The centrifugal tube structure of claim 25, wherein the movable member comprises a piston portion and a push rod, the piston portion is received in the second receiving groove, and the second receiving groove is Internally moving, the push rod is connected to the piston portion; wherein, when the push rod receives an axial thrust, the push rod is adapted to push the piston portion along a longitudinal axis, and straight toward the neck portion Moving to reduce the total volume; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston portion along a longitudinal axis and move linearly away from the neck portion To increase the total volume space; wherein one end of the push rod is connected to the piston portion to be integrally formed with the piston portion; or, one end of the push rod is hooked to the piston portion. The centrifugal tube structure according to claim 26, wherein the movable member is more The bottom cover is movably disposed on the lower edge of the groove of the second receiving groove; wherein the bottom cover is adapted to push the piston portion together when the bottom cover moves toward the neck portion And moving the piston portion toward the neck portion to reduce the total volume space; or, when the bottom cover moves away from the neck portion, the bottom cover is adapted to pull the piston portion together, so that The piston portion moves away from the neck portion to increase the total volume.