TWI481385B - Non - invasive blood glucose measurement circuit module - Google Patents
Non - invasive blood glucose measurement circuit module Download PDFInfo
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- TWI481385B TWI481385B TW101136375A TW101136375A TWI481385B TW I481385 B TWI481385 B TW I481385B TW 101136375 A TW101136375 A TW 101136375A TW 101136375 A TW101136375 A TW 101136375A TW I481385 B TWI481385 B TW I481385B
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- blood glucose
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- 239000008280 blood Substances 0.000 title claims description 33
- 210000004369 blood Anatomy 0.000 title claims description 33
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 27
- 239000008103 glucose Substances 0.000 title claims description 27
- 238000005259 measurement Methods 0.000 title description 4
- 238000012360 testing method Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 239000004973 liquid crystal related substance Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 description 8
- 230000002238 attenuated effect Effects 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 208000017667 Chronic Disease Diseases 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 238000003487 electrochemical reaction Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000012550 audit Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
本發明係有關一種非侵入式血糖量測電路模組，尤指一種非侵入式的血糖量測方法，使病人可克服心理的障礙進行量測血糖濃度，達到控制糖尿病病情的目的。The invention relates to a non-invasive blood glucose measuring circuit module, in particular to a non-invasive blood glucose measuring method, which enables a patient to overcome a psychological obstacle to measure blood sugar concentration and achieve the purpose of controlling diabetes.
現代人發生慢性疾病的例子屢見不鮮，而諸多的慢性病(例如：糖尿病)是需要長期監測或進行立即性的檢查判斷，而傳統醫療單位的檢測方式，是將病人的檢體加以培養、處理及與酵素反應，如此便使檢測的時間拉長，對於病患而言無疑是種身心上的折磨。近來，生物科技的進步使居家的檢測儀器應運而生，藉由科學化的檢測方式，以提供慢性病患者自行測量，再將該檢驗的數據提供予相關醫療專業人仕參考，因此醫療人員得以快速根據病患情況予以適當地治療。The case of chronic diseases in modern people is not uncommon, and many chronic diseases (such as diabetes) require long-term monitoring or immediate examination and judgment. The traditional medical unit detects the patient's sample, processes it, and The enzyme reaction, so that the detection time is lengthened, is undoubtedly a physical and mental torture for the patient. Recently, the advancement of biotechnology has led to the emergence of home-based testing equipment. By scientifically testing methods, patients with chronic diseases are provided with self-measurement, and the data of the test is provided to relevant medical professionals for reference. Therefore, medical personnel can quickly According to the patient's condition, appropriate treatment.
目前血糖量測的儀器多半是以侵入式的方式為之，其程序多半是利用一尖物(如：針)扎於身體中(如：手指)以取得血液檢體，再將該檢體與一酵素反應以產生電化學反應，而血糖量測儀器即可根據該電化學反應所產生的細微電壓或電流來量測出血糖的濃度，由醫務人員來解讀血糖濃度是否被控制在一定的範圍中。但是扎針的過程中常使病人產生恐懼，進而產生抗拒的心理，而病人可能對於準時按照規定進行量測這件事打了折扣，而本發明正為一種非侵入式的血糖量測電路模組及量測方法，可克服上述 病人心理的障礙。At present, most of the instruments for measuring blood sugar are in an invasive manner. Most of the procedures are performed by using a pointed object (such as a needle) in the body (such as a finger) to obtain a blood sample, and then the sample is An enzyme reacts to produce an electrochemical reaction, and the blood glucose measuring instrument can measure the blood sugar concentration according to the fine voltage or current generated by the electrochemical reaction, and the medical staff can interpret whether the blood sugar concentration is controlled within a certain range. in. However, in the process of pinning, the patient often causes fear, which in turn generates a resistance, and the patient may discount the measurement according to the regulations on time. The present invention is a non-invasive blood glucose measurement circuit module and Measuring method can overcome the above Patient psychological barriers.
基於解決以上所述習知技藝的缺失，本發明為一種非侵入式血糖量測電路模組，主要目的為提供一種非侵入式的血糖量測方法，使病人可克服心理的障礙進行量測血糖濃度，達到控制糖尿病病情的目的。Based on solving the above-mentioned shortcomings of the prior art, the present invention is a non-invasive blood glucose measuring circuit module, and the main purpose thereof is to provide a non-invasive blood glucose measuring method, which enables a patient to overcome psychological obstacles and measure blood sugar. Concentration, to achieve the purpose of controlling diabetes.
為達上述目的，本發明一種非侵入式血糖量測電路模組，係包括有：一頻率產生器，用以產生一工作頻率；一低通濾波器，用以濾除該工作頻率之非線性波形信號，並輸出一線性波形信號；一信號放大器，用以放大該低通濾波器輸出之該線性波形信號；一電阻衰減器，接收該信號放大器之該線性波形信號，並輸出一衰減波形信號；一耦合器，接收該電阻衰減器之該衰減波形信號，且該耦合器連接有一感測器，該感測器與接近人體部位產生一共振頻率，該共振頻率改變該衰減波形信號後，輸出一耦合感測信號；一比較器，與該耦合器連接，用以比較該衰減波形信號與該耦合感測信號差異，並輸出一增益值；一微控制單元，與該頻率產生器及該比較器相連接，發出一控制信號來控制該頻率產生器，並記錄該比較器之該增益值後，計算輸出一血糖濃度值；以及 一顯示單元，與該微控制單元連接，用以顯示該血糖濃度數值。To achieve the above objective, a non-invasive blood glucose measuring circuit module of the present invention includes: a frequency generator for generating an operating frequency; and a low pass filter for filtering nonlinearity of the operating frequency a waveform signal and outputting a linear waveform signal; a signal amplifier for amplifying the linear waveform signal outputted by the low pass filter; a resistance attenuator receiving the linear waveform signal of the signal amplifier and outputting an attenuated waveform signal a coupler receiving the attenuation waveform signal of the resistor attenuator, and the coupler is connected with a sensor, and the sensor generates a resonance frequency with the proximity body portion, and the resonance frequency changes the attenuation waveform signal, and then outputs a coupled sensing signal; a comparator coupled to the coupler for comparing the difference between the attenuated waveform signal and the coupled sensing signal, and outputting a gain value; a micro control unit, and the frequency generator and the comparing Connected with a control signal to control the frequency generator, and record the gain value of the comparator, calculate the output of a blood glucose concentration value as well as A display unit is coupled to the micro control unit for displaying the blood glucose concentration value.
為進一步對本發明有更深入的說明，乃藉由以下圖示、圖號說明及發明詳細說明，冀能對 貴審查委員於審查工作有所助益。In order to further explain the present invention, it will be helpful to review the review by the following illustrations, illustrations, and detailed descriptions of the invention.
茲配合下列之圖式說明本發明之詳細結構，及其連結關係，以利於 貴審委做一瞭解。The detailed structure of the present invention and its connection relationship will be described in conjunction with the following drawings to facilitate an understanding of the audit committee.
請參閱圖1所示，係為本發明之非侵入式血糖量測電路模組之功能方塊示意圖，其係包括有：一頻率產生器11，用以產生一工作頻率；一低通濾波器12，用以濾除該工作頻率之一非線性波形信號，並輸出一線性波形信號；一信號放大器13，用以放大該低通濾波器12輸出之該線性波形信號；一電阻衰減器14，接收該信號放大器13之該線性波形信號，並輸出一衰減波形信號；一耦合器15，接收該電阻衰減器14之該衰減波形信號，該耦合器15連接有一感測器16，該感測器16之接收頻率係為1GHz至4GHz，該感測器16與接近人體部位(如：手指)產生一共振頻率，該共振頻率改變該衰減波形信號後，輸出一耦合感測信號；一比較器17，與該耦合器15連接，用以比較該衰減波形信號與該耦合感測信號差異，並輸出一增益值；一微控制單元18，與該頻率產生器11及該比較器17相連接，發出一控制信號來控制該頻率產生器11，並記錄該比較器17之該差異值後，計算輸出一血糖濃度值；一顯示單元 19，與該微控制單元18連接，用以顯示該血糖濃度數值，該顯示單元19係為一發光二極體顯示器(LED Display)、液晶顯示器(TFT Display)、電子顯示紙或可撓式顯示裝置。Please refer to FIG. 1 , which is a functional block diagram of a non-invasive blood glucose measuring circuit module of the present invention, which includes: a frequency generator 11 for generating an operating frequency; and a low pass filter 12 a non-linear waveform signal for filtering the operating frequency and outputting a linear waveform signal; a signal amplifier 13 for amplifying the linear waveform signal output by the low-pass filter 12; a resistor attenuator 14 for receiving The linear waveform signal of the signal amplifier 13 outputs an attenuated waveform signal; a coupler 15 receives the attenuated waveform signal of the resistor attenuator 14. The coupler 15 is connected to a sensor 16, and the sensor 16 is connected. The receiving frequency is from 1 GHz to 4 GHz, and the sensor 16 generates a resonant frequency with a body part (such as a finger), and after the resonant frequency changes the attenuation waveform signal, a coupled sensing signal is output; a comparator 17, And the coupler 15 is connected to compare the difference between the attenuation waveform signal and the coupled sensing signal, and output a gain value; a micro control unit 18 is connected to the frequency generator 11 and the comparator 17 After issuing a control signal to control the frequency generator 11, and records the difference value of the comparator 17, the output of a calculated value of blood glucose concentration; a display unit 19, connected to the micro control unit 18 for displaying the blood glucose concentration value, the display unit 19 is an LED display, a liquid crystal display (TFT Display), an electronic display paper or a flexible display Device.
請參閱圖2所示，係為本發明之感測偵測頻率與功率之比值示意圖，其中Y軸的單位是功率(dB)；X軸的單位是頻率(GHz)，當人體部位(如：手指)接近圖1所揭露感測器16時，即可與耦合器15產生一共振頻率，該共振頻率改變該衰減波形信號後，輸出一感測波形信號，而該衰減波形信號與該耦合感測信號之增益量，經計算和比對該波形偏移量關係與血糖濃度的關係可求得一參考增益波形，於另一血糖測試可得一對照增益波形，將該參考增益波形與該對照增益波形相比較後，即可獲得一偏移量的值，該偏移量即為判斷血糖值高低的依據，可藉由上述該顯示單元19做一顯示。Please refer to FIG. 2 , which is a schematic diagram of the ratio of the sensing detection frequency to the power of the present invention, wherein the unit of the Y axis is power (dB); the unit of the X axis is the frequency (GHz), when the body part (eg: When the finger is close to the sensor 16 disclosed in FIG. 1 , a resonant frequency can be generated with the coupler 15 , and after the resonant frequency changes the attenuation waveform signal, a sensing waveform signal is output, and the attenuation waveform signal and the coupling sense are outputted. The gain amount of the measured signal is calculated and compared with the relationship between the waveform offset and the blood glucose concentration to obtain a reference gain waveform, and another blood glucose test can obtain a contrast gain waveform, and the reference gain waveform is compared with the comparison. After the gain waveforms are compared, an offset value is obtained, which is the basis for determining the blood glucose level, and can be displayed by the display unit 19 described above.
藉由上述圖1至圖2之揭露，即可瞭解本發明一種非侵入式血糖量測電路模組及量測方法，主要為提供一種非侵入式的血糖量測方法，使病人可克服心理的障礙進行量測血糖濃度，達到控制糖尿病病情的目的，於商業市場上具有極大的商機，故提出專利申請以尋求專利權之保護。The non-invasive blood glucose measuring circuit module and the measuring method of the present invention can be understood by the above-mentioned FIG. 1 to FIG. 2, mainly to provide a non-invasive blood glucose measuring method, so that the patient can overcome the psychological Obstacles measure the blood glucose concentration to achieve the purpose of controlling diabetes, and have great business opportunities in the commercial market. Therefore, patent applications are filed to seek patent protection.
綜上所述，本發明之結構特徵及各實施例皆已詳細揭示，而可充分顯示出本發明案在目的及功效上均深賦實施之進步性，極具產業之利用價值，且為目前市面上前所未見之運用，依專利法之精神所述，本發明案完全符合發明專利之要件。In summary, the structural features and embodiments of the present invention have been disclosed in detail, and can fully demonstrate the progress of the invention in terms of purpose and efficacy, and is of great industrial value, and is currently The unprecedented use in the market, according to the spirit of the patent law, the invention is fully in line with the requirements of the invention patent.
唯以上所述者，僅為本發明之較佳實施例而已，當不能以之限定本發明所實施之範圍，即大凡依本發明申請專利範圍所作之均等變化與修飾，皆應仍屬於本發明專利涵蓋之範圍內，謹請 貴審查委員明鑑，並祈惠准，是所至禱。The above is only the preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, that is, the equivalent variations and modifications made by the scope of the present invention should still belong to the present invention. Within the scope of the patent, I would like to ask your review committee to give a clear understanding and pray for it. It is the prayer.
11‧‧‧頻率產生器11‧‧‧frequency generator
12‧‧‧低通濾波器12‧‧‧Low-pass filter
13‧‧‧信號放大器13‧‧‧Signal Amplifier
14‧‧‧電阻衰減器14‧‧‧Resistor attenuator
15‧‧‧耦合器15‧‧‧ Coupler
16‧‧‧感測器16‧‧‧Sensor
17‧‧‧比較器17‧‧‧ Comparator
18‧‧‧微控制單元18‧‧‧Micro Control Unit
19‧‧‧顯示單元19‧‧‧Display unit
圖1係為本發明之非侵入式血糖量測電路模組之功能方塊示意圖； 圖2係為本發明之感測偵測頻率增益與功率之比值示意圖。1 is a functional block diagram of a non-invasive blood glucose measuring circuit module of the present invention; 2 is a schematic diagram showing the ratio of the gain and the power of the sensing detection frequency of the present invention.
11‧‧‧頻率產生器11‧‧‧frequency generator
12‧‧‧低通濾波器12‧‧‧Low-pass filter
13‧‧‧信號放大器13‧‧‧Signal Amplifier
14‧‧‧電阻衰減器14‧‧‧Resistor attenuator
15‧‧‧耦合器15‧‧‧ Coupler
16‧‧‧感測器16‧‧‧Sensor
17‧‧‧比較器17‧‧‧ Comparator
18‧‧‧微控制單元18‧‧‧Micro Control Unit
19‧‧‧顯示單元19‧‧‧Display unit
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| TW101136375A TWI481385B (en) | 2012-10-02 | 2012-10-02 | Non - invasive blood glucose measurement circuit module |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW101136375A TWI481385B (en) | 2012-10-02 | 2012-10-02 | Non - invasive blood glucose measurement circuit module |
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| TW201414456A TW201414456A (en) | 2014-04-16 |
| TWI481385B true TWI481385B (en) | 2015-04-21 |
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| TWI678630B (en) * | 2018-01-16 | 2019-12-01 | 中央研究院 | A system and method for non-invasively estimating hba1c and blood glucose level |
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| TW201414456A (en) | 2014-04-16 |
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