TWI477755B - Nucleic acid purification device - Google Patents

Description

Nucleic acid extraction equipment

The present invention relates to an extraction apparatus, and more particularly to a nucleic acid extraction apparatus for extracting nucleic acids for use with a deep well plate.

According to, nucleic acid extraction is a common experimental method applied to research or detection such as genetics, molecular biology or animal and plant diseases. In order to quickly and efficiently process a large number of samples, as shown in FIG. 1 , a processor-controlled automated nucleic acid extraction device 10 is proposed, which is mainly provided with a lateral slide rail 12 and a body 11 on a body 11 . A moving base 13 is disposed along the lateral rail 12, and a first longitudinal rail 14 and a second longitudinal rail 15 are respectively disposed on opposite sides of the opposite ends of the moving base 13, so that the lower side is formed with a plurality of longitudinal rods 161 A plate member 16 is coupled to the first longitudinal rail 14 and moves along the same, and a second plate member 17 and a second longitudinal rail member 15 are disposed on the lower side of the first plate member 16 and are provided with a plurality of guide grooves 171. Join and move along it.

Wherein, the guiding groove 171 of the second plate member 17 is combined with a sleeve 18 formed with a plurality of longitudinal sleeves 181, so that the sleeve 18 is controlled by the first and second longitudinal rails 14, 15 to make the first and the first The two plates 16 and 17 are stacked, and the longitudinal sleeves 181 are sleeved on the outside of the longitudinal rods 161 to form an extraction mechanism, thereby corresponding to the lateral slide rails 12 on the frame 11 of the conventional nucleic acid extraction device 10. A limiting slot 111 for the deep hole plate is disposed at the portion, the moving base 13 is controlled to be laterally displaced through the horizontal sliding rail 12, and the first and second longitudinal rails 14, 15 control the The extraction mechanism is longitudinally displaced to achieve the purpose of extending the extraction mechanism into the deep-hole plate for nucleic acid extraction operation, and by setting the kit 18 as an experimental consumable outside the longitudinal rod 161, the extraction device is easy to maintain and clean, and the sample is It is not easy to be affected by cross-contamination.

It is worth noting that the validity of the detection results of nucleic acid extraction samples is directly affected by the preservation environment. Therefore, the samples are transported from the field to the laboratory, and the risk of poor quality preservation of the samples is required. However, the known nucleic acids The extraction device 10 has the above-mentioned functions and purposes, and has the necessity of providing a set of lateral slide rails 12 and two sets of longitudinal rails 14, 15 and an extraction mechanism, resulting in a large overall size of the device, which is difficult to carry and difficult to carry in the laboratory. The on-site inspection is carried out in a place other than the conventional one, so that the conventional nucleic acid extraction apparatus 10 has the necessity of further improvement.

The object of the present invention is to provide a nucleic acid extraction device, which is mainly provided with a lateral displacement mechanism for adjusting the position of the deep hole plate and a longitudinal displacement mechanism for driving the extraction mechanism up and down in the extraction device, by using the lateral displacement mechanism And the longitudinal displacement mechanism is separately disposed on the nucleic acid extraction device to achieve the purpose of easy maintenance and repair of the nucleic acid extraction device of the present invention.

Another object of the present invention is to provide a nucleic acid extraction apparatus which is mainly designed to greatly reduce the overall volume of the nucleic acid extraction apparatus through the structural design of the lateral displacement mechanism and the longitudinal displacement mechanism.

In order to achieve the above objective, the present invention provides a nucleic acid extraction apparatus comprising: a susceptor; a lateral displacement mechanism disposed on the pedestal and coupled to a carrier for driving the carrier on the base Displacement on the seat; a longitudinal displacement mechanism having a longitudinal limit slide rail and a first drive slide rail disposed parallel thereto and a second drive rail disposed on the base, the first drive slide The rail is provided with a first slider, and the second driving rail is provided with a second slider. The first and second sliders are respectively driven by two power sources at the ends of the first and second driving rails. The longitudinal limiting rail is disposed on a side between the first and second driving rails, and the first slider and the second slider each form a sliding slot and the longitudinal limiting sliding rail sliding group And the first slider is located on the upper side of the second slider; an extraction mechanism is coupled to the first slider and the second slider of the longitudinal displacement mechanism, so that the extraction mechanism is the longitudinal displacement mechanism Controlled driving for nucleic acid extraction.

Therefore, the present invention improves the movement of the moving base of the conventional nucleic acid extraction device while driving the two longitudinal rails and the extracting mechanism thereof along the lateral slide rail via the structure and the arrangement of the lateral displacement mechanism and the longitudinal displacement mechanism. The problem is to avoid the problem of increasing the mechanical load and power loss when the equipment is operated, the positioning accuracy caused by the longitudinal rails being pinned by the lateral rails, and the equipment being difficult to maintain; further, the present invention is designed by the above-mentioned nucleic acid extraction device. The utility model has the advantages of greatly reducing the overall volume of the device, and the nucleic acid extraction device of the invention has the advantages of good portability and is more suitable for use in a place outside the laboratory.

Another object of the present invention is to provide a nucleic acid extraction device, wherein the deep-hole plate carrier is provided with a card positioning structure for positioning and positioning with the periphery of the deep-hole plate, so as to achieve a true positioning of the deep-hole plate during the extraction process. The carrier is intended to be laterally displaced with the carrier.

In order to achieve the above object, the nucleic acid extraction device of the present invention is used in combination with a deep-hole plate, wherein at least one positioning protrusion is provided in each of the positioning block notches of the carrier, the deep hole The opposite side edges of the bottom of one of the plates are formed with positioning recesses corresponding to the number and position of the notches, so that the opposite side edges of the bottom of the deep-hole plate are accommodated in the gaps of the two positioning blocks of the carrier of the nucleic acid extraction device. The deep hole plate positioning concave and the carrier positioning convex concave and convex are clamped and positioned.

The techniques, means, and other techniques employed in connection with the present invention to achieve the above objectives For the sake of efficacy, the preferred embodiments are described in detail with reference to the drawings.

[study]

10‧‧‧Nucleic acid extraction equipment

11‧‧‧ ‧ frame

111‧‧‧ Limit slot

12‧‧‧ Horizontal rails

13‧‧‧ sports base

14‧‧‧First longitudinal rail

15‧‧‧Second longitudinal rail

16‧‧‧First board

161‧‧‧ longitudinal rod

17‧‧‧Second board

171‧‧ ‧ guide slot

18‧‧‧ kit

181‧‧‧Longitudinal casing

〔this invention〕

20‧‧‧ Pedestal

21‧‧‧floor

22‧‧‧ side panels

23‧‧‧ visor

24‧‧‧ front board

241‧‧‧Long opening

25‧‧‧ Backplane

26‧‧‧First position sensor

27‧‧‧Second position sensor

28‧‧‧ top board

30‧‧‧Transverse displacement mechanism

31‧‧‧Horizontal Limit Rails

32‧‧‧ drive gear

321‧‧‧Power source

40‧‧‧Seat

41‧‧‧ body

411, 412‧‧‧ boards

413‧‧ ‧ guide slot

42‧‧‧ Positioning block

421‧‧‧ gap

422‧‧ ‧ room

423‧‧‧ hole

424‧‧‧ beads

425‧‧‧Flexible parts

426‧‧‧plugs

43‧‧‧Positioning convex

44‧‧‧Horizontal slider

45‧‧‧ rack

50‧‧‧Longitudinal displacement mechanism

51‧‧‧ longitudinal limit rails

52‧‧‧First drive rail

521‧‧‧Power source

53‧‧‧Second drive rail

531‧‧‧Power source

54‧‧‧First slider

541‧‧‧Chute

542‧‧‧Slip groove

543‧‧‧flash slot

544‧‧‧Sensor components

55‧‧‧Second slider

551‧‧‧Chute

552‧‧‧Slip groove

553‧‧‧flash slot

554‧‧‧Sensor components

60‧‧‧Extraction agency

61‧‧‧ rods

611‧‧‧cross bar

612‧‧‧ longitudinal rod

613‧‧‧ joint parts

62‧‧‧Components

621‧‧‧ slots

622‧‧‧ holes

623‧‧‧ Limit recess

624‧‧‧Connecting parts

625‧‧‧ Positioning Sensor

63‧‧‧ kit

631‧‧‧ Rod

632‧‧‧ casing

633‧‧‧Limited convex

70‧‧‧Deep hole plate

71‧‧‧ top

72‧‧‧ bottom

721‧‧‧ side edge

722‧‧‧Positioning concave

73‧‧‧ hole slot

80‧‧‧ processor

81‧‧‧Control unit

82‧‧‧Power storage unit

83‧‧‧Power

X‧‧‧ direction

Y‧‧‧ direction

Z‧‧‧ direction

Figure 1 is a schematic diagram of a device for a conventional nucleic acid extraction device.

Fig. 2 is a schematic view showing the decomposition of the nucleic acid extraction apparatus of the present invention and its use in combination with a deep well plate.

Fig. 3A is a schematic cross-sectional view showing the combined positioning structure of the nucleic acid extraction apparatus and the deep well plate of the present invention.

Fig. 3B is a partially enlarged schematic view showing a combination of the positioning structure of Fig. 4A of the present invention.

Fig. 4 is a schematic perspective view showing the lateral displacement mechanism of the nucleic acid extraction apparatus of the present invention.

Figure 5 is a schematic side elevational view (1) of the longitudinal displacement mechanism of the nucleic acid extraction apparatus of the present invention.

Figure 6 is a schematic side elevational view (2) of the longitudinal displacement mechanism of the nucleic acid extraction apparatus of the present invention.

Figure 7 is a schematic plan view of the longitudinal displacement mechanism of the nucleic acid extraction apparatus of the present invention.

Figure 8 is a schematic diagram showing the electrical connection of the nucleic acid extraction device of the present invention with a processor and a power source.

Figure 9A is a schematic view showing the operational state of the apparatus of the present invention and the kit to be set.

Figure 9B is a schematic view showing the operation state of the apparatus of the present invention and the set kit and the deep-hole plate already provided.

Referring to Figures 2 through 8, a preferred embodiment of a nucleic acid extraction apparatus provided by the present invention is described below. As shown in FIG. 2, the nucleic acid extraction device of the present invention is configured to fix a deep-hole plate 70 for performing a nucleic acid extraction operation. The nucleic acid extraction device mainly includes a susceptor 20 adjacent to each other but independently disposed on the susceptor 20 a lateral displacement mechanism 30 and a longitudinal displacement mechanism 50, a carrier 40 that is coupled to the lateral displacement mechanism 30 to drive the base 20, and a set of extraction mechanisms 60 disposed in the longitudinal displacement mechanism 50, wherein : As shown in the second and fourth figures, the base 20 has a bottom plate 21, and the lateral displacement mechanism 30 is disposed on the bottom plate 21 of the base 20, and is provided with a lateral limiting slide 31 and a pair of lateral limit positions. a drive gear 32 disposed on the middle side of the slide rail 31, the drive gear 32 being coupled to a power source 321 disposed on a lower side of the base 20, defining an X direction along the direction in which the lateral limit slide rail 31 extends, and A Y-direction is perpendicular to the X-direction; the opposite side of the bottom plate 21 of the base 20 has two side plates 22 disposed along the Y-direction, so that a shutter 23 is spanned on the two side plates 22, and the base 20 is provided A front plate 24 is disposed between the lateral displacement mechanism 30 and the longitudinal displacement mechanism 50, and a back plate 25 is disposed on the rear side of the longitudinal displacement mechanism 50 with respect to the front plate 24. The front plate 24 defines an elongated opening 241. The extraction mechanism 60 is disposed to be displaced, and a top plate 28 is disposed on the upper side of the front plate 24, through the shielding plate 23, the front plate 24 and the top plate 28 to shield the longitudinal displacement mechanism 50, thereby avoiding sample spillage during operation or Dropping to the lateral displacement mechanism 30 or the longitudinal displacement mechanism 50 causes the mechanical device to be destroyed.

As shown in FIG. 2, the carrier 40 is assembled with the lateral displacement mechanism 30. The carrier 40 has a body 41 and two positioning blocks 42 each recessed with a notch 421. The base 41 has two plates. The two pieces 411 and 412 are formed in a stack, and a guiding groove 413 is formed between the two plates 411 and 412. The two positioning blocks 42 are disposed in the Y direction and the notches 421 are oppositely disposed on the seat. The two sides of the body 41 are provided with a lateral slider 44 slidably coupled to the lateral limiting slide rail 31 and a rack 45 meshing with the driving gear 32 along the X direction. The seat 40 is displaced by the rack 45 for the drive gear 32 in the X direction as shown in Fig. 7.

As shown in Figures 2, 3A, and 3B, the deep-hole plate 70 is formed with a top portion 71 and a bottom portion 72, and a plurality of holes 73 are recessed from the top portion 71 toward the bottom portion 72 thereof. 70 nucleic acid extraction equipment can be positioned in the correct position, so that the extraction operation goes smoothly, this hair The nucleic acid extraction device is further provided with at least one positioning protrusion 43 in the notch 421 of each positioning block 42 of the carrier 40, and the opposite side edges 721 of one of the bottom portions 72 of the deep hole plate 70 are formed with corresponding notches 421. The positioning recess 722 of the number and position of the protrusions 43 , whereby when the opposite side edges 721 of the bottom portion 72 of the deep hole plate 70 are received in the notches 421 of the two positioning blocks 42 of the nucleic acid extraction device carrier 40, the deep holes The positioning recess 722 of the plate 70 and the positioning convex 43 of the carrier 40 are positioned and positioned to ensure that the deep hole plate 70 is located at the correct extraction position.

In the embodiment, the positioning hole 722 of the deep hole plate 70 is formed into a hole structure, and the positioning protrusion 43 of the carrier 40 is formed by a bead body, and as shown in FIG. 4B, the positioning of the carrier 40 is as shown in FIG. 4B. The block 42 is provided with at least one chamber 422 communicating with the notch 421. The bottom of each of the chambers 422 is formed with a through hole 423 and is provided with a bead body 424 disposed in the insertion hole 423 and a chamber 422. The opening plug 426 and a positioning structure formed by the two ends abutting against the bead body 424 and the elastic member 425 of the plug member 426 restrict the bead body 424 and the elastic member 425 to the interior of the chamber 422 by the plug member 426 The elastic member 425 is provided with an elastic force to embed the bead body 424 in the insertion hole 423 to be positioned with the hole structure of the deep hole plate 70, or to provide a margin for the bead body 424 to retreat from the insertion hole 423, so as to facilitate the deep hole. The plate 70 is fixedly disposed on the carrier 40.

As shown in the figures 5, 6, and 7, the longitudinal displacement mechanism 50 is disposed on the base 20 and has a longitudinal limiting slide 51 and a first driving rail 52 and a second driving rail 53. The first and second driving slide rails 52 and 53 are disposed along the Z direction, and the first driving rail 52 is disposed with a first slider 54. The second driving rail 53 is provided with a second slider 55. The first and second sliders 54 and 55 respectively have two power sources 521 disposed at the ends of the first and second driving rails 52 and 53. The 531 is connected, and the longitudinal limiting rail 51 is disposed on a side between the first and second driving rails 52, 53. The first slider 54 and the The second sliders 55 are formed with a sliding groove 541, 551 and the longitudinal limiting sliding rail 51 is slidably assembled, and the first sliding block 54 is located on the upper side of the second sliding block 55.

The present invention is capable of effectively reducing the overall volume of the nucleic acid extraction device. As shown in FIGS. 5 and 6, the first slider 54 of the longitudinal displacement mechanism 50 is formed with a sliding groove 542 and the first driving slide 52 is disposed. And the first slider 54 forms a flash slot 543 corresponding to the side of the second driving rail 53 to be received and displaced along the second driving rail 53; the second slider 55 is formed with a sliding slot 552 and the The second driving rail 53 is disposed to be assembled, and the second slider 55 forms a flash slot 553 corresponding to the side of the first driving rail 52 to be received and displaced along the first driving rail 52; The arrangement of the flashing grooves 543 and 553 allows the first and second sliding blocks 54, 55 to be slidably disposed along the longitudinal limiting sliding rail 51 so as to overlap each other. The structural design not only reduces the overall volume of the device, but also blocks each of the sliders. It is set on the double track slip (that is, it is set on the drive slide rail and the longitudinal slide rail), and has the functions of strengthening the longitudinal displacement mechanism 50, such as structural strength, slip stability and positioning accuracy.

As shown in FIG. 8, the nucleic acid extraction device of the present invention is electrically connected to a processor 80, and the nucleic acid extraction device is electrically controlled by the control unit 81 and the processor 80, wherein the processor 80 is coupled to the processor 80. The control unit 81 and the power storage unit 82 are electrically connected. The control unit 81 is composed of a component including an associated control button, a touch screen or other control nucleic acid extraction device. The power storage unit 82 can be stored and used by the utility power supply, and can also be used. The power supply from the commercial power is directly supplied to the nucleic acid extraction device via the power storage unit 82 to facilitate the experimental use of the nucleic acid extraction device of the present invention (direct power supply from the commercial power), or pre-storage of electric power for on-site inspection outside the laboratory. In the embodiment, the first drive rail 52 power source 521, the second drive rail 53 power source 531 of the longitudinal displacement mechanism 50, and the drive gear 32 power source 321 of the lateral displacement mechanism 30 are coupled to a processor. 80 electrical connection.

In addition, please refer to FIGS. 5 and 6 , the base 20 of the nucleic acid extraction device of the present invention is mainly used for assembling the longitudinal limiting slide 51 of the longitudinal displacement mechanism 50 , the first slider 54 and the The second sliders 55 are respectively provided with a sensing component 544, 554, and the first surface sensor 26 and the opposite side of the first slider 54 and the second slider 55 are respectively provided with a first position sensor 26 and a The second position sensor 27 is electrically connected to the processor 80 for sensing the displacement position of the first slider 54 and the second slider 55.

As shown in FIGS. 5 and 6, the extraction mechanism 60 includes a rod row member 61, a set of connectors 62, and a kit 63 inserted into the assembly member 62, wherein the rod row member 61 has a a crossbar 611 extending in the Y direction and a plurality of longitudinal rods 612 extending in the Z direction on the lower side of the crossbar 611, the end of the crossbar 611 having a coupling member 613 disposed in an L form and the first slider 54 The connecting member 62 is disposed along the Y direction and has a connecting member 624 disposed at an end in an inverted L form, and the second sliding member 55 is assembled. The connecting member 62 has a slot 621 and a The socket 621 is connected to the hole 622. The socket 62 of the assembly 62 is inserted into a rod portion 631 of a sleeve 63, and the plurality of holes 62 and 622 of the assembly 62 are formed on the rod portion 631. The lower longitudinal sleeve 632 is in communication with the nozzle.

Wherein, the set of connectors 62 is assembled with the end of one of the longitudinal ends of the connecting member 624 at a position higher than the height of the second slider 55 so that the sleeve 63 is indeed seated on the rod row member 61. Externally; thereby, the rod row member 61 of the nucleic acid extraction apparatus of the present invention controls the driving of the longitudinal displacement mechanism 50 to pull the assembly member 62 to be displaced in the Z direction, and the sleeve 63 is longitudinally displaced by the assembly member 62. The mechanism 50 controls the drive to be displaced in the Z direction and is placed outside the rod row member 61 or retracted from the rod row member 61.

The above is the main components of the creation embodiment and its configuration description, as for this To create the operation mode and function of the preferred embodiment, please refer to the drawings of Figures 8, 9A and 9B for the following description.

As described above, the nucleic acid extraction apparatus of the present invention mainly places the deep-hole plate 70 on the carrier 40, and the positioning block 42 of the carrier 40 and the side edge 721 of the deep-hole plate 70 are embossed and positioned, and as shown in FIG. As shown, the lateral displacement mechanism 30 drives the deep orifice plate 70 to move in the X direction on the base 20 to adjust the position so that the orifice plate 73 of the deep orifice plate 70 to be subjected to the extraction operation is accurately positioned and extracted from the rod 60 of the extraction mechanism 60. The longitudinal rod 612 corresponds to the position, and finally the longitudinal displacement mechanism 50 drives the extraction mechanism 60 to move the adjustment position in the Z direction to extend into the deep orifice plate 70 for extraction.

It should be noted that the rod row member 61 of the extraction mechanism 60 is fixedly disposed on the first slider 54, and the kit 63 of the extraction mechanism 60 is an experimental consumable, which must be replaced due to different samples, and is easy to be inserted. The position can be accurately positioned, so that the vertical rod 612 of the rod row member 61 cannot be correctly matched, thereby affecting the accuracy of the position of the extraction mechanism 60 and the hole slot 73 of the deep hole plate 70. Therefore, as shown in FIGS. 8 and 9A, the extraction mechanism 60 of the nucleic acid extraction apparatus of the present invention, and the end portion of the assembly 62 away from the longitudinal displacement mechanism 50, is provided with a limiting recess 623 formed into a hole structure, and The set 63 631 is correspondingly provided with a limiting protrusion 633 shaped as a bump, so that the sleeve 63 is inserted into the slot 621 of the set of connectors 62 and is the limiting recess 623 and the limiting convex 633 Carding limit.

In addition, the socket 62 of the extraction mechanism 60 is disposed adjacent to the slot end of the longitudinal displacement mechanism 50, and a positioning sensor 625 is electrically connected to the processor 80 for sensing the assembly position of the kit 63. To confirm whether the kit 63 is actually positioned, and when the kit 63 is inserted into the slot 621 of the assembly 62, the positioning sensor 625 senses and forms an electrical signal, and automatically electrically drives the longitudinal displacement. The mechanism 50 is displaced for the extraction operation.

By providing the positioning structure of the above-mentioned extraction mechanism 60 kit 63, the nucleic acid extraction apparatus of the present invention is operated, as shown in Figs. 9A and 9B, first by the longitudinal displacement mechanism 50 assembly 62 descending from the upper rod row member 61. The rod 612 is inserted into the slot 621 of the assembly 62, so that the sleeve 63 is constrained from the limiting recess 623 and the end of the sleeve 63 is pressed against the positioning. The sensor 625 is configured to transmit the signal back to the processor 80, thereby driving the longitudinal displacement mechanism 50 to drive the assembly 62 and the kit 63 upwardly to the outside of the rod row member 61, and then the deep hole plate 70 is disposed on the load. On the seat 40, the final control longitudinal displacement mechanism 50 drives the entire set of extraction mechanism 60 to descend into the hole 73 of the deep hole plate 70, so that the extraction mechanism 60 is vertically displaced in the Z direction in the deep hole plate 70 for extraction operation. .

In summary, the present invention separately sets the lateral displacement mechanism 30 and the longitudinal displacement mechanism 50 on the nucleic acid extraction device through the structural arrangement of the nucleic acid extraction device, and the first and second sliders 54 and 55 are disposed along the second. The driving slide rail and the limiting slide rail sliding device have the advantages of greatly reducing the overall volume of the nucleic acid extraction device, increasing the slip stability, and the like, and also making the longitudinal displacement mechanism 50 and the lateral displacement mechanism 30 easy to maintain; The positioning structure is provided on the carrier 40 and the assembly mechanism 60 of the extraction mechanism 60, which can greatly deepen the positioning accuracy of the orifice plate 70 and the extraction mechanism 60 kit 63, so that the extraction operation is smoother; in particular, it is worth mentioning that The invention greatly reduces the volume of the nucleic acid extraction device, and after the power storage unit 82 is provided, it can be directly powered by the commercial power or stored after being used, and is not only small in size, easy to carry, but also solves the problem of power supply, and can be inspected in the field outside the laboratory to ensure The validity of the sample test results.

20‧‧‧ Pedestal

21‧‧‧floor

22‧‧‧ side panels

23‧‧‧ visor

24‧‧‧ front board

241‧‧‧Long opening

28‧‧‧ top board

40‧‧‧Seat

41‧‧‧ body

411, 412‧‧‧ boards

42‧‧‧ Positioning block

421‧‧‧ gap

50‧‧‧Longitudinal displacement mechanism

60‧‧‧Extraction agency

61‧‧‧ rods

62‧‧‧Components

63‧‧‧ kit

70‧‧‧Deep hole plate

71‧‧‧ top

72‧‧‧ bottom

721‧‧‧ side edge

722‧‧‧Positioning concave

73‧‧‧ hole slot

X‧‧‧ direction

Y‧‧‧ direction

Z‧‧‧ direction

Claims (10)

A nucleic acid extraction device comprising: a base; a lateral displacement mechanism disposed on the base and coupled to a carrier for driving the carrier to be displaced on the base; a longitudinal displacement mechanism having a longitudinal direction a limiting slide rail and a first driving rail and a second driving rail disposed in parallel with the lateral displacement mechanism are disposed on the base, and the first driving rail is provided with a first slider. The second driving slide rail is provided with a second sliding block, and the first and second sliding blocks respectively drive displacements of the two power sources disposed at the ends of the first and second driving sliding rails, and the longitudinal limiting sliding rails are Provided on a side between the first and second driving slide rails, the first slider and the second slider are each formed with a sliding slot and the longitudinal limiting sliding rail sliding assembly, and the first slider Located on the upper side of the second slider; an extraction mechanism is coupled to the first slider and the second slider of the longitudinal displacement mechanism, so that the extraction mechanism controls the driving of the longitudinal displacement mechanism for nucleic acid extraction. The nucleic acid extraction device of claim 1, wherein the first drive rail power source, the second drive rail power source, and one of the lateral displacement mechanisms of the longitudinal displacement mechanism are The processor is electrically connected, and the processor is electrically connected to a control unit and a power storage unit, so that the nucleic acid extraction device is electrically controlled by the control unit and the processor. The nucleic acid extraction device of claim 1, wherein the first slider of the longitudinal displacement mechanism is formed with a sliding groove and the first driving rail is disposed, and the first slider corresponds to Forming a flash slot on the side of the second drive rail to accommodate and along the second drive rail position Shifting; the second slider is formed with a sliding groove and the second driving rail is disposed, and the second slider is formed on the side of the first driving rail to form a flash slot for accommodating and along the first A drive rail displacement. The nucleic acid extraction device of claim 1, wherein the nucleic acid extraction device is electrically connected to and electrically controlled by a processor, wherein the base has a back plate for assembling the longitudinal limit of the longitudinal displacement mechanism. The first slider and the second slider are respectively provided with a sensing component, and the back panel is respectively provided with a first position sensor on opposite sides of the first slider and the second slider. And a second position sensor electrically connected to the processor for sensing a displacement position of the first slider and the second slider. The nucleic acid extraction device of claim 1, wherein the lateral displacement mechanism is disposed on the base and is provided with a lateral limiting slide rail and a pair of lateral limiting rails disposed on an intermediate side thereof. a driving gear, the driving gear is coupled to a power source disposed on a lower side of the base, defining an extending direction along the lateral limiting rail as an X direction, and a Y direction perpendicular to the X direction; the carrier, a positioning block having a body and a recessed portion, wherein the two positioning blocks are disposed on the two sides of the base body along the Y direction, and the notch is oppositely disposed on the lower side of the base body. The limit slide rail is assembled with a lateral slider and a rack meshing with the drive gear, so that the carrier is displaced in the X direction by the rack for the drive gear; the longitudinal displacement mechanism is defined along the The longitudinal limiting rail, the first driving rail and the second driving rail extend in a direction of Z direction; the extraction mechanism, the rod row member and the group of fasteners are extended along the Y direction, The rod row member drives the group for the longitudinal displacement mechanism to drive the drive The Z-direction displacement along the member, and The kit is controlled by the longitudinal displacement mechanism to be displaced in the Z direction via the set of connectors, and is placed outside the rod row member or retracted from the rod row member. The nucleic acid extraction device of claim 5, wherein the base has a bottom plate, and the bottom plate has two side plates disposed along the Y direction on opposite sides thereof, so that a shutter is spanned on the two side plates; The carrier system has a two-plate stack shape, and a guide groove for the shutter is disposed between the two plates, so that the lateral displacement mechanism drives the carrier to be displaced along the base shutter. The nucleic acid extraction device of claim 5, which is used in conjunction with a deep-hole plate, wherein at least one positioning protrusion is provided in each of the positioning block notches of the carrier, and one of the deep-hole plates is at the bottom The opposite side edges are formed with positioning recesses corresponding to the number and position of the notches, so that the opposite side edges of the bottom of the deep-hole plate are accommodated in the notch of the two positioning blocks of the carrier of the nucleic acid extraction device, and the deep-hole plate is positioned. The concave and the positioning of the carrier are convex and concave. The nucleic acid extraction device of claim 5, wherein the positioning concave of the deep-hole plate is formed into a hole structure, the positioning protrusion of the carrier is formed into a bead body, and each positioning block of the carrier is provided. There is at least one chamber, and a hole is formed in the bottom of each chamber, and each of the chambers is provided with a bead disposed on the through hole, a plug disposed at the opening of the chamber, and a top end abutting The elastic member of the bead and the plug. The nucleic acid extraction device of claim 5, wherein the rod row of the extraction mechanism has a cross bar extending in the Y direction and a plurality of longitudinal rods extending in the Z direction on the lower side of the cross bar. The end of the crossbar has a joint disposed in an L form and the first slide Block assembly; the set of connectors is disposed along the Y direction and the end portion has a connecting member disposed in an inverted L form and is coupled to the second slider, the set member has a slot and a connection with the slot a set of sockets for inserting one of the sets of rods, such that the set of strips of the set are in communication with a plurality of longitudinal sleeves formed on the underside of the stem, such that the kit is The Z-direction displacement, the sleeve of the kit is sleeved on the outer side of the rod row member or retracted from the rod row member longitudinal rod. The nucleic acid extraction device according to claim 9 is electrically connected to and electrically controlled by a processor, wherein the extraction mechanism assembly slot is disposed adjacent to the slot end of the longitudinal displacement mechanism. The sensor is electrically connected to the processor for sensing the set position of the kit, and the set of the connecting member is provided with a limiting recess away from the end of the longitudinal displacement mechanism, and the set rod portion is provided with a limiting protrusion. The kit is inserted into the set of sockets and is restrained by the limit recess and the limit convex bump.