TWI476007B - Oral compositions and uses thereof - Google Patents

Description

Oral composition and use thereof

The present invention relates to an oral composition comprising an orally acceptable carrier and a cerium oxide abrasive, the cerium oxide abrasive comprising an average particle diameter of from 5 μm to 20 μm, an oil absorption of from 60 cc/100 g to 120 cc/100 g, and 4 to 11 Einlehner hardness precipitated amorphous ceria compound, and method of use thereof.

Background of the invention

Abrasives in the oral composition remove and physically scrub the external surface of the teeth. This scrubbing action removes the organic biofilm (i.e., film) on the surface of the tooth, which is primarily formed by salivary proteins, bacteria, and bacterial by-products. Films can also be contaminated and discolored by foods such as coffee, tea and berries as well as by tobacco smoke, cationic compounds and chromogenic bacteria. Physical removal of the soiled film is a simple and effective way to remove unwanted surface staining and discoloration that occurs daily. In addition, the physical removal of the film also removes plaque bacteria on the surface of the film, thereby minimizing the likelihood of gingivitis, periodontitis, and sputum formation. However, oral compositions such as dentifrice should not be so highly abrasive that they can cause potential damage to the enamel or tissue. Accordingly, it is desirable to develop an oral composition that saturates the cleansing and/or polishing benefits of the oral composition while minimizing harmful abrasion to avoid potentially damaging the oral surface. Preferably, the oral composition has a high film cleansing ratio (PCR), but a low degree of tooth wear, which is measured as radioactive dental abrasion (RDA).

In a generally accepted conventional practice, the RDA value of the oral composition is typically maintained below 250 to avoid damage to the dentin/dentin. However, in order to achieve higher PCR, the amount and hardness of the abrasive must typically increase, which is conventionally known to increase RDA. For example, it has been observed that when the RDA value of the dentifrice composition exceeds several values (e.g., above 100 to 115), the dentifrice does not necessarily exhibit a corresponding increase in the cleansing effect of the dentifrice. It has been challenged to formulate oral compositions having a PCR greater than 80 or 90 but still having an RDA of less than 250.

Summary of the invention

It has been surprisingly found that the use of special cerium oxide abrasives in oral care compositions imparts excellent cleansing power (e.g., high PCR values) while at the same time reducing damage to hard tooth surfaces (e.g., low PDA). The cerium oxide abrasive used in the present invention maintains its integrity while wiping off soft substances such as plaque and film on the surface of the teeth. However, the cerium oxide abrasive breaks or breaks under shear (such as during brushing) as a result of interaction with the hard enamel or dentate surface. In this regard, the oral compositions of the present invention provide excellent cleansing and/or polishing benefits while minimizing the desired low RDA for potential damage to enamel or dentin. In addition, the compositions of the present invention provide for cleansing and/or polishing of the tooth surface. Clean and/or polished abrasives can be classified by various physical parameters. As is appreciated by those skilled in the art, a single abrasive species typically performs at least some cleaning and polishing at the same time.

In one embodiment, the present invention is directed to a composition 1.0, an oral composition comprising an orally acceptable carrier and a ceria abrasive comprising an average particle size of from 5 μm to 20 μm, and 4 to 11 Einlehner hardness of cerium oxide compound.

The additional composition of the present invention is the following composition:

1.1 Composition 1.0 wherein the cerium oxide abrasive has an average particle size of from 8 μm to 11 μm, such as from 9 μm to 13 μm.

1.2 Composition 1.0 or 1.1 wherein the cerium oxide abrasive has an absorption of from 60 cc / 100 g to 120 cc / 100 g, such as from 70 cc / 100 g to 110 cc / 100 g, such as 80 cc / 100 g to 100 cc / 100 g, such as linseed oil absorption.

1.3 Any of the preceding compositions wherein the cerium oxide abrasive has an Einlehner hardness of from 5 to 10, such as from 6 to 9.

1.4 any of the foregoing compositions having a film clean ratio (PCR) of from 80 to 105, such as from 85 to 100, or from 90 to 95;

1.5 any of the foregoing compositions having a radioactive dentin abrasion (RDA) of less than 150, such as from 90 to 130, from 100 to 120, or from 105 to 115;

1.6 any of the foregoing compositions having a PCR/RDA ratio of from 0.5 to 1.5, such as 0.8, or 1.

1.7 Any of the foregoing compositions, wherein the cerium oxide abrasive is from 1% to 95% by weight of the composition.

1.8 any one of the preceding compositions, wherein the cerium oxide abrasive has a d _{10 of} from 2.5 μm to 2.9 μm;

1.9 any one of the preceding compositions, wherein the cerium oxide abrasive is broken when the oral composition is applied to a hard surface in the oral cavity (such as enamel or dentin);

1.10. Any of the foregoing compositions, wherein when the composition is used in the oral cavity, the ceria abrasive is broken into particles having a d _{10 of} from 2.3 μm to 2.6 μm;

1.11 Any of the preceding compositions wherein the cerium oxide abrasive ruptures when subjected to a sufficient amount of shear.

1.12 any composition 1.9 to 1.11, wherein the oral composition is brushed on the teeth for at least 30 seconds to 5 minutes;

1.13 any composition 1.9 to 1.12, wherein after application to the hard surface of the oral cavity, the average particle size of the cerium oxide abrasive is reduced by 16% to 20%;

1.14 Any composition 1.9 to 1.13 in which the d _{10 of the} cerium oxide abrasive is reduced by 9% to 12% after application to a hard surface in the oral cavity.

1.15 Any of the foregoing compositions comprising an effective amount of a fluoride salt, such as from 0.01% to 2% by weight, such as from 0.1% to 0.2% by weight of the total composition.

1.16 Any of the foregoing compositions, comprising a fluoride ion source comprising a tin (II) fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluoroantimonate, ammonium fluoroantimonate, ammonium fluoride , fluoride fluoride of ammonium fluoride, and combinations thereof.

1.17 Any of the foregoing compositions comprising 500 to 5000, 1000 to 1500, or 1450 ppm fluoride ions.

1.18 Any of the preceding compositions comprising at least one surfactant.

1.19 Any of the preceding compositions comprising at least one surfactant selected from the group consisting of sodium lauryl sulfate, cocoamidopropyl betaine, and combinations thereof.

1.20 Any of the foregoing compositions comprising an anionic surfactant.

1.21 Any of the preceding compositions comprising sodium lauryl sulfate.

1.22 Any of the preceding compositions comprising at least one humectant.

1.23 Any of the preceding compositions comprising at least one humectant selected from the group consisting of glycerin, sorbitol, and combinations thereof.

1.24 Any of the preceding compositions comprising at least one polymer.

1.25 any one of the foregoing compositions comprising at least one member selected from the group consisting of polyethylene glycol, polyvinyl methyl ether maleic acid copolymer, polysaccharides (such as cellulose derivatives such as carboxymethyl cellulose, or A polysaccharide gum, such as a tricyanidin or carrageenan, and a combination thereof.

1.26 Any of the preceding compositions comprising a flavoring, aroma and/or colorant.

1.27 Any of the preceding compositions comprising an antimicrobial agent.

1.28 Any of the foregoing compositions comprising a halogenated diphenyl ether (triclosan), an herbal extract or an essential oil (such as rosemary extract, rucola, menthol, cineole, methyl salicylate) ), biguanide preservatives (such as chlorhexidine, alexidine or octenidine), quaternary ammonium compounds (such as cetylpyridinium chloride), phenolic preservatives, Hexetidine, povidone iodine, delmopinol, salifluor, metal ions (such as zinc salts such as zinc citrate), blood base, propolis And an oxidizing agent (such as hydrogen peroxide, buffered sodium peroxyborate or sodium percarbonate).

1.29 Any of the foregoing compositions comprising triclosan.

1.30 Any of the foregoing compositions comprising an antibacterial agent in an amount of from 0.01 to 5, from 0.01 to 1.0, or 0.3% by weight of the total composition.

1.31 any of the foregoing compositions, comprising a tooth desensitizing agent;

1.32 any of the preceding compositions comprising a tooth desensitizing agent selected from the group consisting of potassium salts, capsaicin, eugenol, sulfonium salts, zinc salts, chloride salts, or combinations thereof;

1.33 of any of the preceding compositions, comprising a tooth whitening compound;

1.34 any of the foregoing compositions, which are dental powders;

1.35 any of the foregoing compositions, which comprises water;

1.36 Any of the foregoing compositions which are toothpaste or gel.

1.37 Any of the preceding compositions, wherein the RDA of the oral composition is calculated by the following method comprising applying 1 to 5 ml of the oral composition slurry to a surface of 1 to 10 cm ^{2 to} contact the surface with ³² P radiation. A constant force of 2 to 5 Newtons is used to brush the tooth surface 300 strokes, wherein each stroke causes the surface to move 1 to 10 cm ² of the tooth and measure the RDA value.

1.38 Any of the preceding compositions, wherein when the composition is applied to the oral cavity (e.g., in contact with a hard tooth surface), the RDA of the composition decreases over time, and the RDA of the oral composition is calculated by the method identified in 1.37. However, the book is that the number of trips used at the initial time A is less than the number of trips used at a later time B, such as 300 trips equal to about 2 minutes;

1.39 Any of the preceding compositions wherein the RDA of the oral composition for 5 seconds in the oral cavity is 1.3 to 1.6 times the RDA of the composition for 1 to 5 minutes (e.g., 2, 3, or 4 minutes) in the oral cavity.

1.40 composition 1.39, wherein the surface is a clean head of the toothbrush;

1.41 Composition 1.39 or 1.40, wherein the method of calculating RDA is that the slurry comprises from 50% to 100% by weight of the oral composition.

1.42 Any of the foregoing compositions wherein the Einlehner hardness is measured in brass nets per 174,000 revolutions.

1.43 Any of the compositions 1.0 to 1.41, wherein the Einlehner hardness is measured in brass nets per 100,000 revolutions.

1.44 Composition 1.42 or 1.43, wherein the Einlehner hardness is 100 g of a slurry of cerium oxide abrasive in 1 liter of water.

1.45 Any of the preceding compositions wherein the aqueous slurry of 10% cerium oxide abrasive has a PCR of from 65 to 80, such as from 68 to 76, or 72.

1.46 any of the preceding compositions, wherein the aqueous slurry of 10% cerium oxide abrasive has an RDA of 75 to 91, such as 79 to 87, or 83;

1.47. Any one of the preceding compositions, wherein the aqueous slurry of 10% cerium oxide abrasive has a PCR/RDA ratio of from 0.7 to 0.9, such as from 0.8 to 0.9, such as 0.86;

1.48 Any of the preceding compositions wherein the aqueous slurry of 15% cerium oxide abrasive has a PCR of from 68 to 84, such as from 62 to 80, or 76.

1.49 any one of the preceding compositions, wherein the aqueous slurry of 15% cerium oxide abrasive has an RDA of 85 to 105, such as 90 to 100, or 95;

1.50 any of the foregoing compositions, wherein the aqueous slurry of 15% cerium oxide abrasive has a PCR/RDA ratio of from 0.7 to 0.9, such as from 0.76 to 0.8, such as 0.86;

1.51 Any of the foregoing compositions wherein the aqueous slurry of 20% cerium oxide abrasive has a PCR of from 76 to 92, such as from 80 to 88, or 84.

Any of the foregoing compositions, wherein the aqueous slurry of 20% cerium oxide abrasive has an RDA of 85 to 101, such as 89 to 97, or 93;

Any of the foregoing compositions, wherein the aqueous slurry of 20% cerium oxide abrasive has a PCR/RDA ratio of from 0.8 to 1.0, such as from 0.85 to 0.95, such as 0.9;

1.54 Any of the preceding compositions wherein the aqueous slurry of 30% cerium oxide abrasive has a PCR of from 78 to 94, such as from 82 to 90, or 86.

Any of the foregoing compositions, wherein the aqueous slurry of 30% cerium oxide abrasive has an RDA of from 100 to 124, such as from 106 to 118, or 112;

Any of the foregoing compositions, wherein the aqueous slurry of 30% cerium oxide abrasive has a PCR/RDA ratio of from 0.6 to 0.9, such as from 0.7 to 0.8, such as 0.77;

1.57 Composition 1.0 wherein the cerium oxide abrasive has a median particle size of from 8 μm to 11 μm, such as, but not limited to, from 9 μm to 13 μm, from 8 μm to 12 μm, or from 8 μm to 11 μm.

1.58 Any of the compositions 1.9 to 1.12, wherein after application to a hard surface in the oral cavity, the particle size of the cerium oxide abrasive is reduced by 16% to 20%.

The cerium oxide compound used as the abrasive of the present invention may be amorphous cerium oxide, precipitated cerium oxide, or amorphous precipitated cerium oxide. In one embodiment, the cerium oxide abrasive consists essentially of the cerium oxide compound described herein. The cerium oxide abrasive described herein can function as a tooth cleanser, a dental polish, and/or an anti-sensitizer.

An additional aspect of the invention relates to the surprising discovery that broken cerium oxide abrasive particles can help treat tooth sensitivity because broken particles can block tubule occlusion. In addition, it has been surprisingly found that smaller particles are more effective in removing debris and stains from cracks in the oral cavity, particularly adjacent interdental surfaces of the teeth.

The invention also encompasses the method 2.0, a method for improving oral health, comprising applying an effective amount of the oral composition of any specific example of 1.0 to 1.55 to the oral cavity of a patient in need thereof, such as a method

1. Reduce or inhibit the formation of caries,

2. Reduce, repair or inhibit enamel pre-crack damage, such as by quantifying light-induced fluorescence (QLF) or conductance measurement (ECM) detection,

3. Reduce or inhibit tooth demineralization and promote tooth remineralization,

4. Reduce the allergenicity of teeth,

5. Reduce or inhibit gingivitis,

6. inhibit the formation of microbial biofilm in the oral cavity,

7. Reduce plaque accumulation, and / or

8. Clean teeth and mouth.

Other embodiments of the invention will be apparent to those skilled in the art.

Detailed description of the invention

As used herein, all measurement levels described herein are based on the total composition weight, unless otherwise indicated. In addition, all of the references cited herein are incorporated herein by reference in their entirety. However, in the event of any conflict between the definitions in this disclosure and the definitions in the cited references, the present disclosure controls.

As used herein, "safe and effective amount" means a sufficient amount to treat the oral cavity (e.g., to reduce plaque, gingivitis, and/or smear) under conditions and structures that do not harm the oral cavity.

As used herein, "orally acceptable carrier" means one or more materials used in the oral administration of the compositions of the present invention in a safe and effective manner.

As used herein, "clean" generally refers to the removal of contaminants, dust, impurities, and/or foreign matter from the surface of the target. For example, in the context of an oral surface where the surface is a tooth enamel, the cleansing can remove at least some of the film or stain, such as a plaque biofilm, film or calculus.

As used herein, "polishing" generally refers to a finishing or scouring process that makes the surface smoother and/or more lustrous. Polishing and cleansing can also provide a bright surface with smudge removal, such as whitening of the tooth surface.

In various embodiments, an oral composition having an abrasive is provided. Preferably, the cerium oxide abrasive is a precipitated amorphous cerium oxide compound.

The cerium oxide of the present invention may have an average particle diameter of from 5 μm to 205 μm. The average particle size of the particles can be measured by any means known in the art. For example, the average particle size can be measured using a Malvern Particle Size Analyzer, Model Mastersizer S, Malvern Instruments, Inc. (Southborough, Massachusetts, USA), wherein the xenon-krypton gas laser beam is projected through a transparent light containing an abrasive suspended in an aqueous solution. Transparent cell. The light rays illuminating the particles pass through an angle that is inversely proportional to the particle size. The photodetector array measures the amount of light at several predetermined angles. The electrical signal proportional to the measured luminous flux value is then processed by a microcomputer system to determine the particle size distribution of the subject abrasive against the scattering pattern expected from the theoretical particles defined by the refractive index of the sample and the aqueous dispersion. The average particle size considers the skewed particle size and the size distribution of the particles.

As used herein, d ₁₀ refers to a population of particles having a 10% diameter limit (ie, a 10% population equal to or less than a d ₁₀ value).

It has been surprisingly found that when the oral composition is brushed against a hard tooth surface such as a dentin or enamel, the abrasive particles incorporated into the oral composition are broken or broken. It has also been surprisingly found that when the oral composition is brushed against a soft surface of the oral cavity or a soft biofilm (such as a film or plaque), the abrasive particles incorporated into the oral composition substantially retain their original dimensions.

The ceria abrasive of the present invention may have a specific oil absorption of 60 cc / 100 g to 120 cc / 100 g of linseed oil. In one embodiment, the ceria abrasive has an oil absorption of from 70 cc/100 g to 110 cc/100 g. In one embodiment, the ceria abrasive has an oil absorption of from 80 cc/100 g to 100 cc/100 g. In one embodiment, the ceria abrasive has an oil absorption of from 40 cc/100 g to 60 cc/100 g. The amount of oil absorbed can be determined by various means known to those skilled in the art. For example, the oil absorption can be determined by absorption per 100 grams of linseed oil or dibutyl phthalate (DBP) or abrasive. The oil absorption value can be measured using ASTM Rub-Out Method D281.

The abrasive of the present invention can have a specific Einlehner hardness of 4 to 11. The Einlehner hardness can be determined by various means known to those skilled in the art. For example, the Einlehner At-1000 Abrader can measure the hardness of abrasive particles in the following manner: Weighing and exposing the Fourdrinier metal mesh (ie copper or brass) to the abrasive suspension (eg, 10% abrasive water) The suspension) acts for a given number of revolutions. The hardness value is expressed as the weight loss per milliliter of the number of revolutions (eg, 100,000 revolutions) of the long net machine wire mesh. In the present invention, the Einlehner hardness of the cerium oxide abrasive used in the present invention is determined by using a brass mesh. 100 g of cerium oxide was added to 1 liter of water to rotate the slurry up to 100,000 or 174,000 revolutions.

The abrasive component of the present invention can be incorporated into an oral care product at a level of from 1% to 95% by weight. The amount of abrasive present depends on the particular form of the oral care composition. For example, when the oral care composition is a toothpaste or gel, it may contain from 1% to 75% of the abrasive. When the oral care composition is a dental powder, it may contain from 50% to 95% of the abrasive.

PCR is a method known to those skilled in the art to measure the efficacy of removing tooth stains relative to the standard. The PCR values referred to herein are obtained by the method described in "In Vitro Removal of Stain with Dentifrice", GK Stookey et al., J. Dental Research, 61, 123-9 (1982). Modifications The PCR methods used herein are described in U.S. Patent Nos. 5,658,553 and 5,651,958 to Rice. In this modification, a clear film material applied to a bovine tooth first, and then a combination of a thin film material with a tea, coffee and FeCl ₃ of the contamination, and in the original method by Stookey et al, both the film and the stain Apply at the same time. The composition of the invention may have a PCR of from 80 to 105. In one embodiment, the PCR is from 85 to 100. In another aspect, the PCR is from 90 to 95.

The compositions of the present invention may have an RDA value of less than 150, such as from 90 to 130, from 100 to 120, from 105 to 115. The RDA value can be determined by any number of methods known to those skilled in the art. For example, the RDA value can be determined according to the methods proposed in U.S. Patent Nos. 4,340,583, 4,420,312 and 4,421,527, and Hefferreh, Journal of Dental Research, July-August 1976, p. 563-573. Usually, the radiated ³² P dentate is brushed with a composition such as an oral cavity. The quality of the teeth removed from the brushed dentin was quantified by the ³² P analysis observed in the abrasive slurry. The amount of dentin wear is based on a standard composition that is brushed on the tooth, typically calcium pyrophosphate, which has an RDA of 100. Typically, less abrasive composition has a lower RDA value.

The compositions of the invention may have a PCR/RDA ratio of 0.5 to 1.5. In one embodiment, the PCR/RDA ratio can be 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, or 1.5. The PCR/RDA ratio is used to determine the relative dosing of the cleansing and wear characteristics of the oral care composition (e.g., dentifrice or toothpaste composition).

Useful ceria abrasive materials for preparing the oral compositions of the present invention are available from Davison Chemical Division of W. R. Grace & Co. (Baltimore, Maryland, USA) under the trade name GRACE VP5. In one embodiment, the cerium oxide is INEOS (now PQ Corp.) Sorbosil AC43 cerium oxide. In one embodiment, the AC43 cerium oxide has the following properties, including, but not limited to, an average particle size of 2.7 to 4.0 microns (determined by MALVERN MASTERSIZER), a screening residue of +45 μm, and a humidity loss of 8.0% maximum at 105 °C. The ignition loss at 1000 ° C was 14.0% maximum, and the pH in the aqueous suspension was 5.5 to 7.5.

Other abrasives may also be utilized in the present compositions, but it is contemplated that the compositions of the present invention may contain a single ceria abrasive compound as previously described, and may be substantially free of other niobium or cerium oxide abrasives and compounds.

Orally acceptable carriers are well known in the art and may contain surfactants, humectants, thickeners, foaming agents, fluoride ion sources, flavorings, colorants, chelating agents, polymers, enzymes, water, Active substances, and other substances. The oral composition can further comprise an orally acceptable carrier. The particular composition of the carrier will depend on the intended use of the composition. The carrier can be in the liquid phase, semi-solid phase, or solid phase. The oral composition can be tooth powder (including toothpaste, tooth powder, and prevent paste), candy (including glue, beads, and chews), film, paint-on gel, or familiar with abrasives. Any other form known. The choice of a particular carrier component depends on the desired product form.

The active ingredient contains, for example, an antibacterial active agent, an anticalculus agent, an anticonvulsant, an anti-inflammatory agent, an anti-sensitivity agent, an enzyme, a nutrient, and the like. The actives useful herein are for a human or lower animal patient to which the active is administered, in a safe and effective amount sufficient to have a desired therapeutic or prophylactic effect, without undue adverse effects (eg, toxicity, irritation, or allergic reaction) ), when used in the process of the invention, commensurate with a reasonable risk/benefit ratio, as the case may be, in the compositions of the invention. The particular safe and effective amount of active will vary depending on the particular condition being treated, the condition of the patient, the nature of the concurrent therapy (if any), the particular active employed, the particular dosage form, the carrier employed, and the desired dosage. Changes in the factors of dosage regimen. The active ingredients for treating such conditions include those discussed in U.S. Patent Publication No. 2003/0206874 to Doyle et al. The actives of the present invention are also discussed in U.S. Patent No. 6,290,933 to Durga et al. and U.S. Patent No. 6,685,921 to Lawlor.

Fluoride salts and fluoride ion sources (e.g., soluble fluoride salts) are well known in the art and can be incorporated into the compositions of the present invention. Representative fluoride ion sources include, but are not limited to, tin (II) fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluoroantimonate, ammonium fluoroantimonate, amine fluoride, ammonium fluoride, And their combinations. In several embodiments, the fluoride ion source comprises tin (II) fluoride, sodium fluoride, amine fluoride, sodium monofluorophosphate, and mixtures thereof. In several embodiments, the oral care compositions of the present invention may also contain a source of fluoride ions or a fluorine-providing component in an amount sufficient to supply 25 ppm to 5,000 ppm of fluoride ions, typically at least 500 ppm, such as 500 to 2000 ppm, such as 1000 to 1600 ppm, such as 1450 ppm. The fluoride ion source may be added to the composition of the invention at a level of from 0.01% to 10% by weight in one embodiment, or from 0.03% to 5% by weight in another embodiment, and in another embodiment The composition is in the range of 0.1% by weight to 1% by weight in the middle; however, it is to be understood that the weight of the fluoride salt providing the appropriate level of fluoride ion will vary significantly depending on the relative ionic weight in the salt, and the skilled artisan can quickly determine the amount. .

The oral compositions of the present invention may comprise one or more agents to increase the amount of foam produced when the mouth is brushed. Such blowing agents are known to those skilled in the art. Illustrative examples of agents that increase the amount of foam include, but are not limited to, polyoxyethylene and several polymers including, but not limited to, alginate polymers. Polyoxyethylene can increase the amount of foam and foam thickness produced by the oral care vehicle component of the present invention. Polyoxyethylene is also generally known as polyethylene glycol ("PEG") or polyethylene oxide. Polyoxyethylenes suitable for the present invention will have a molecular weight of from 200,000 to 7,000,000. In one embodiment, the molecular weight will be from 600,000 to 2,000,000, and in another embodiment from 800,000 to 1,000,000. The polyoxyethylene may be present in an amount from 1% to 90% by weight, in one embodiment from 5% to 50% by weight, and in another embodiment from 10% to 20% by weight of the oral care composition of the present invention. Care carrier ingredients. The amount of blowing agent (i.e., a single dose) in the oral care composition is from 0.01 to 0.9% by weight, from 0.05 to 0.5% by weight, and in another embodiment from 0.1 to 0.2% by weight.

The compositions of the present invention may also incorporate one or more surfactants known in the art. Suitable surfactants include those which are reasonably stable throughout a broad pH range, such as anionic, cationic, nonionic or zwitterionic surfactants. Suitable surfactants are more fully described in, for example, U.S. Patent No. 3,959,458 to Agricola et al., U.S. Patent No. 3,937,807 to Haefele, and U.S. Patent No. 4,051,234 to the name of U.S. Pat. In several embodiments, useful anionic surfactants herein include water soluble salts of alkyl sulfates having from 10 to 18 carbon atoms in the alkyl group and water soluble salts of fatty acid sulfonated monoglycerides having from 10 to 18 carbon atoms. salt. Sodium lauryl sulfate, sodium lauryl sarcosinate, and sodium coconut monoglyceride sulfonate are examples of this type of anionic surfactant. Mixtures of anionic surfactants can also be utilized. In another embodiment, a cationic surfactant useful in the present invention can be broadly defined as a derivative of an aliphatic quaternary ammonium compound having a long alkyl chain having from 8 to 18 carbon atoms, such as lauryl chloride. Methylammonium, cetylpyridinium chloride, cetyltrimethylammonium bromide, diisobutylphenoxyethyldimethylbenzylammonium chloride, coconut alkyltrimethylammonium nitrite, fluorine Whale-based pyridine, and mixtures thereof. The cationic surfactant is described as a quaternary ammonium fluoride as described in U.S. Patent No. 3,535,421, the disclosure of which is incorporated herein by reference. Several cationic surfactants can also be used as bactericides for the composition. In one embodiment of the invention, the oral composition is substantially free of cationic surfactants. Description of the Compositions of the Invention The nonionic surfactant can be broadly defined as a compound produced by the condensation of an alkylene oxide (essentially hydrophilic) with an organic hydrophobic compound which can be an essential aliphatic or alkyl aromatic. Examples of suitable nonionic surfactants include, but are not limited to, Pluronics, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with a reaction product of propylene oxide and ethylenediamine, An ethylene oxide condensate of an aliphatic alcohol, a long chain tertiary amine oxide, a long chain tertiary phosphine oxide, a long chain dialkyl fluorene, and a mixture of such materials. In a number of specific examples, the zwitterionic synthetic surfactants useful in the present invention can be broadly defined as derivatives of aliphatic quaternary ammonium, phosphonium and sulfonium compounds, wherein the aliphatic group can be linear or branched. And one of the aliphatic substituents has 8 to 18 carbon atoms and one contains an anionic water-soluble group such as a carboxyl group, a sulfonate, a sulfate, a phosphate or a phosphonate. Examples of surfactants suitable for inclusion in the composition include, but are not limited to, sodium alkyl sulfate, sodium lauryl sarcosinate, cocoamidopropyl betaine, and polysorbate 20, and combination.

The compositions of the present invention may include an anionic surfactant such as sodium lauryl sulfate. The surfactant or mixture of compatible surfactants may be present in the compositions of the invention from 0.1% to 5.0% by weight, in another embodiment from 0.3% to 3.0% by weight and in another embodiment 0.5% by weight. Up to 2.0% by weight of the total composition.

The compositions of the present invention may also comprise one or more flavoring agents known to those skilled in the art. Flavoring agents useful in the practice of the present invention include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and the like. Examples of essential oils include spearmint oil, peppermint oil, wintergreen oil, sassafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, lime oil, grapefruit oil, and orange oil. Also useful are chemicals such as menthol, fragrant celery, and fennel. Peppermint oil and spearmint oil are used in several specific examples. The flavoring agent is incorporated into the oral composition at a concentration of 0.1 to 5% by weight and 0.5 to 1.5% by weight. The flavoring dose in the individual oral care composition dose (i.e., a single dose) is from 0.001 to 0.05% by weight and in another embodiment from 0.005 to 0.015% by weight.

The oral care compositions of the present invention may also optionally comprise one or more chelating agents which are capable of aligning the calcium found in the bacterial cell wall. Combining this calcium weakens the bacterial cell wall and enlarges bacterial lysis. Another group that may be present in the chelating agents of the present invention is soluble pyrophosphate. The pyrophosphate used in the present composition may be any alkali metal pyrophosphate. In several embodiments, the salt comprises a tetra alkali metal pyrophosphate, a dialkali metal diacid pyrophosphate, a tribasic metal monoacid pyrophosphate, and mixtures thereof, wherein the alkali metal is sodium or potassium. Salts are used in both their hydrated and unhydrated forms. An effective amount of pyrophosphate for use in the present compositions is generally sufficient to provide at least 1.0% by weight pyrophosphate ion, 1.5% to 6% by weight, 3.5% to 6% by weight of the ion.

The oral composition of the present invention also optionally contains one or more polymers such as polyethylene glycol, polyvinyl methyl ether maleic acid copolymer, polysaccharides (such as cellulose derivatives such as carboxymethyl groups). Cellulose, or polysaccharide gum, such as Sanxian gum or carrageenan). The acidic polymer (e.g., polyacrylate gel) can be provided in the form of its free acid or partially or fully neutralized water soluble alkali metal (e.g., potassium and sodium) or ammonium salt. Several specific examples include 1:4 to 4:1 maleic anhydride or a copolymer of an acid with another polymerizable ethylenically unsaturated monomer, such as methyl vinyl ether having a molecular weight (MW) of 30,000 to 1,000,000 (A) Oxyethylene). Such copolymers are available, for example, from Gantrez AN 139 (M.W. 500,000), AN 119 (M.W. 250,000) and S-97 medical grade (M.W. 70,000) of GAF Chemicals Corporation. Other operating polymers include, for example, maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrolidone, or ethylene (the latter is available, for example). 1:1 copolymer of Monsanto EMA No. 1103, MW 10,000 and EMA Grade 61), and acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutyl vinyl ether or A 1:1 copolymer of N-vinyl-2-pyrrolidone. Suitable as a polymerized olefin-based or ethylenically unsaturated carboxylic acid containing an activated carbon-to-carbon olefin double bond and at least one carboxyl group, that is, an acid containing an olefinic double bond, the olefinic double bond is very fast in polymerization because of its It is present in the monomer molecule at the α-β position relative to the carboxyl group or as a partial methylene end group. The acid is described as acrylic acid, methacrylic acid, ethacrylic acid, α-chloroacrylic acid, crotonic acid, β-acryloxypropionic acid, sorbic acid, α-chlorosorbic acid, cinnamic acid, β-styrylacrylic acid, Muconic acid, itaconic acid, citraconic acid, mesaconic acid, glutaconic acid, aconitic acid, α-phenylacrylic acid, 2-benzylacrylic acid, 2-cyclohexylacrylic acid, leucovoric acid, umbrella acid, anti Butylene diacid, maleic acid and anhydride. Other different olefin monomers copolymerizable with the carboxylic acid monomer include vinyl acetate, vinyl chloride, dimethyl maleate, and the like. The copolymer contains a carboxylate group which is sufficiently water-soluble. Further classified polymeric agents comprise a composition comprising a homopolymer of a substituted acrylamide and/or a homopolymer of an unsaturated sulfonic acid and a salt thereof, particularly wherein the polymer has a molecular weight of from 1,000 to 2,000,000 selected from the group consisting of An unsaturated sulfonic acid of acrylamidoalkyl alkane sulfonic acid (e.g., 2-propenylamine 2 methylpropane sulfonic acid) is described in U.S. Patent No. 4,842,847, issued toJahid et al. reference.

In the preparation of oral care compositions, it is sometimes necessary to add a number of thickening materials to provide the desired consistency or to stabilize or enhance the properties of the formulation. In several embodiments, the thickening agent is a carboxyvinyl polymer, carrageenan, hydroxyethyl cellulose, and a water soluble salt of a cellulose ether (eg, sodium carboxymethyl cellulose and carboxymethyl hydroxyethyl cellulose) sodium). Natural gums such as karaya gum, gum arabic, and tragacanth can also be combined. Colloidal magnesium aluminum silicate or finely divided cerium oxide can be used as a component of the thickening composition to further improve the constituent materials. In several embodiments, the thickener is used in an amount from 0.5% to 5.0% by weight of the total composition.

The oral care compositions of the present invention may also optionally comprise one or more enzymes. Useful enzymes include any available protease, glucanohydrolase, endoglycosidase, amylase, dextran allosteric hydrolase (mutanase), lipase and mucinase or compatible mixtures thereof. In several embodiments, the enzyme is a protease, a polyglucosidase, a endoglycosidase, and a dextran allosteric hydrolase. In another embodiment, the enzyme is a mixture of papain, endoglycosidase or polyglucosidase and a dextran allosteric enzyme. Additional enzymes suitable for use in the present invention are disclosed in U.S. Patent No. 5,000,939 to Dring et al., U.S. Patent No. 4,992,420, U.S. Patent No. 4,355,022, U.S. Patent No. 4,154,815, U.S. Patent No. 4,058,595, U.S. Patent No. 3,991,177 And U.S. Patent No. 3,696,191, the disclosure of which is incorporated herein by reference. The enzyme of a mixture of several compatible enzymes in the present invention constitutes 0.002% to 2.0% in one specific example, or 0.05% to 1.5% in another specific example, or 0.1% to 0.5% in yet another embodiment.

Water may also be present in the oral compositions of the present invention. The water used to prepare the commercial oral composition should be deionized and free of organic impurities. The water generally compensates for the difference in composition and comprises from 10% to 90%, from 20% to 60% or from 10% to 30% by weight of the oral composition. This amount of water includes free water added in an amount introduced by other materials such as sorbitol or any of the ingredients of the present invention.

The compositions of the present invention may also include a humectant, such as to prevent the composition from being hardened upon exposure to air. Some humectants can also be given to the dentifrice composition for sweetness or flavor. The humectant which is mainly a pure humectant generally contains 15% by weight to 70% by weight in one specific example or 30% by weight to 65% by weight of the dentifrice composition in another specific example. Suitable humectants include edible polyols such as glycerin, sorbitol, xylitol, propylene glycol, and other polyols and mixtures of such humectants. Mixtures of glycerin and sorbitol can be used in some specific examples as a humectant component of the toothpaste composition herein.

The compositions of the present invention may also comprise one or more antimicrobial agents. Antibacterial agents are known in the art and include benzylic acid, sodium benzylate, potassium benzylate, boric acid, and phenolic compounds such as beta naphthol (betanaphthol), clariparin, thymol, fennel, eucalyptus, and aroma Celery, menthol, phenol, pentanol, hexanol, heptol, octylphenol, hexylbenzenediol, lauryl pyridine chloride, myristyl chloride, cetylpyridinium chloride, cetyl chloride Pyridine, brominated cetylpyridine, and halogenated diphenyl ether (eg, triclosan). The compositions of the present invention may also comprise one or more basic amino acids in the form of a free base or salt, such as arginine. The agent may be added depending on the agent selected, in an effective amount, such as from 1% to 20% by weight, based on the total weight of the composition.

The composition of the present invention may be combined with one or more anti-sensitivity agents such as potassium salts such as potassium nitrate, potassium hydrogencarbonate, potassium chloride, potassium citrate, and potassium oxalate; capsaicin; eugenol; sulfonium salt; zinc salt; Salt and its combination. The agent may be added depending on the agent selected, in an effective amount, such as from 1% to 20% by weight, based on the total weight of the composition. The compositions of the present invention can also be used to treat allergies caused by occlusion of a dentin tubule when applied to a tooth.

The compositions of the present invention may also comprise tooth whitening or tooth bleaching compositions known in the art. Suitable for whitening and bleaching compositions comprising peroxides, metal chlorites, persulphates. The peroxide comprises a hydroperoxide, hydrogen peroxide, a peroxide of an alkali and an alkaline earth metal, an organic peroxy compound, a peroxyacid, and mixtures thereof. The base and alkaline earth metal peroxides include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof. Other peroxides include perborates, urea peroxides, and mixtures thereof. Suitable metal chlorites may include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. The agent may be added depending on the agent selected, in an effective amount, such as from 1% to 20% by weight, based on the total weight of the composition.

In addition to the above ingredients, specific examples of the present invention may contain a plurality of the following diverse dentifrice components. Optionally, ingredients include, but are not limited to, adhesives, soaps, flavors, sweeteners, additional anti-plaque agents, abrasives, and color formers. These and other optional components are further described in U.S. Patent No. 5,004,597 to Majeti, U.S. Patent No. 3,959,458 to Agricola et al., and U.S. Patent No. 3,937,807 to Haefele.

The choice of abrasive for the oral composition can be interpreted as the type of abrasive, fineness (particle size), particle size distribution and amount of abrasive to ensure that the tooth enamel cannot be excessively rubbed during normal use of the composition, but is sufficiently clean And / or polished. In the context of oral care, the efficacy of the abrasive can be expressed in terms of the cleanliness or wear criteria of the dentifrice, ie, the film cleansing ratio (PCR) or the radioactive dentin wear (RDA), respectively. Methods of performing PCR and RDA are known in the art, as described in U.S. Patent Nos. 5,939,051 and 6,290,933.

In several embodiments, the composition is safe for oral use to humans or other animals, and any oral or cosmetically acceptable abrasive that meets the above requirements can be selected for use in the oral composition.

Additional abrasives may also be included in the compositions of the present invention, including aluminum oxide (calcined alumina), diatomaceous earth, pumice, calcium carbonate, cuttlebone, insoluble phosphate, composite resins (eg, melamine resin, phenolic resin). And urea-formaldehyde resin), polycarbonate, boron carbide, microcrystalline wax, microcrystalline cellulose (including a combination of colloidal microcrystalline cellulose and carboxymethyl cellulose), and combinations and derivatives thereof. Among the insoluble phosphates, the useful abrasives are the orthophosphate, polymetaphosphate and pyrophosphate. Examples are dicalcium phosphate dihydrate, dicalcium phosphate dihydrate, calcium hydrogen phosphate, calcium pyrophosphate, beta-calcium pyrophosphate, tricalcium phosphate, calcium metaphosphate, potassium metaphosphate, and sodium metaphosphate.

In several embodiments, the oral composition is in the form of a dentifrice and the exemplary carrier is substantially semi-solid or solid. The carrier can be aqueous, that is, including from 5% to 95% water. In other embodiments, the carrier is substantially non-aqueous. Carriers include, for example, oral active ingredients, surfactants (eg, surfactants, emulsifiers, and foam regulators), viscosity modifiers and thickeners, humectants, diluents, fillers, additional pH changes. A coloring agent, a coloring agent, a preservative, a solvent, and combinations thereof. It is to be understood that although the general attributes of the various materials of the above categories may vary, there may be several attributes in common and any given material may be supplied for multiple purposes within two or more of that type of material. As will be appreciated by those skilled in the art, in addition to the materials previously described, the oral compositions, as appropriate, comprise other materials including, for example, softeners, emollients, mouth feel agents, and the like. Examples of suitable carriers for the oral compositions are discussed in U.S. Patent No. 6,669,929 to Boyd et al., U.S. Patent No. 6,379,654 to Gebreselassie et al., and U.S. Patent No. 4,894,220 to Nabi et al.

The oral composition, as appropriate, includes an anti-calculus composition, such as one or more of the anti-calculus compositions described in U.S. Patent No. 5,292,526 to Gaffar et al. In various embodiments, the anti-calculus composition comprises one or more polyphosphates. The anti-calculus composition may comprise at least one alkali metal or ammonium tripolyphosphate or hexametaphosphate which is wholly or partially neutralized in the oral composition in an amount effective to resist stone. The anticalculus active may also comprise at least one water soluble, linear, molecularly dehydrated polyphosphate salt in an amount effective to resist stone. The anticalculus active may also comprise a mixture of potassium and sodium salts, at least one of which is present as a polyphosphate anticalculus in an amount effective against stone. The anticalculus active agent may also contain a polyphosphate anticalculus agent which is an effective anti-stone amount in the presence of a mixture of sodium and potassium salts. The ratio of potassium to sodium in the composition can be as high as less than 3:1. The polyphosphate may be present in the oral composition in various amounts, for example, in a weight ratio ranging from polyphosphate ion to antibacterial agent in a range from more than 0.72:1 to less than 4:1, or an antibacterial enhancer and polyphosphoric acid. The weight ratio of the root ions ranges from 1:6 to 2.7:1, or the weight ratio of the antimicrobial enhancer to the polyphosphate ranges from 1:6 to 2.7:1. Other useful anticalculus agents include polycarboxylate polymers and polyvinyl methyl ether/maleic anhydride (PVM/MA) copolymers such as GANTREZ .

An additional active agent useful in the dentifrice composition of the present invention is an antibacterial agent which may be present in an amount of from 0.001 to 3.0% by weight of the oral composition. A non-limiting form of useful oral care compound comprising a nonionic antimicrobial comprising phenol and a bisphenol compound, such as a halogenated diphenyl ether, comprising triclosan (2,4,4'-trichloro-2'- Hydroxy-diphenyl ether), triclocarban (3,4,4-trichlorodiphenylurea, 3,4,4-trichlorocarbanilide), and 2-phenoxyethanol, benzyl ester, And carbanilide. The halogenated diphenyl ether (e.g., triclosan) can be present, for example, in an amount of 0.3% by weight of the oral composition.

Suitable for surfactants that are reasonably stable throughout a wide pH range. Such compounds are well known in the art and include non-soap anions (such as sodium lauryl sulfate (SLS), N-myristyl and N-palmitoyl sarcosine), nonionics (such as polysorbates) Polysorbate) 20 (polyoxyethylene 20 sorbitan monolaurate, 20) and polysorbate 80 (polyoxyethylene 20 sorbitan monooleate, 80), Poloxamer 407, trade name available from BASF Corporation F127), cationic, zwitterionic (such as cocoamidopropyl betaine and laurylpropyl betaine), and amphoteric organic synthetic detergents. Examples of suitable surfactants for use in oral compositions are discussed, for example, in U.S. Patent No. 4,894,220 to Nabi et al., U.S. Patent No. 6,555,094 to Glandorf et al., and U.S. Patent No. 6,706,256 to Lawlor et al. In various embodiments, one or more surfactants are present in the oral compositions of the present invention in a range of from 0.001% to 5% or from 0.5% to 2.5%.

As the case for oral compositions, thickeners include natural and synthetic gums and colloids, such as carrageenan (Irish red algae), sancaria, sodium carboxymethylcellulose, starch, polyvinylpyrrolidone, hydroxy Ethyl propyl cellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose. In various embodiments, the thickening agent is present in the dentifrice composition in an amount of from 0.1 to 10% by weight or from 0.5 to 4% by weight.

The orally acceptable carrier vehicle for the preparation of the dentifrice composition optionally comprises a humectant. The humectant can be glycerin, sorbitol, and xylitol, propylene glycol having a molecular weight in the range of 200 to 1,000; or other humectants and mixtures thereof. The humectant concentration typically amounts to 5 to 70% by weight of the oral composition. Water is typically present in an amount of at least 10% by weight, and typically from 25 to 70% by weight of the oral composition.

Synthetic anionic linear polycarboxylates are efficacy enhancers which are optionally used in oral compositions having several active ingredients, including antibacterial agents, anticalculus agents or other active agents in the oral compositions. The anionic polycarboxylate is typically used in the form of its free acid or partially or fully neutralized water soluble alkali metal (e.g., potassium and preferably sodium) or ammonium salt. The terms "synthetic" and "straight line" exclude known thickeners or gelling agents including carboxymethylcellulose and other derivatives of cellulose and natural gum, nor are carbomers having reduced solubility due to cross-linking ( Carbopol).

Preferably, the copolymer is a copolymer of 1:4 to 4:1 maleic anhydride or an acid with another polymerizable ethylenically unsaturated monomer, preferably a methyl vinyl group having a molecular weight (MW) of 30,000 to 1,000,000. Ether (methoxyethylene). One useful copolymer is methyl vinyl ether/maleic anhydride. Examples of such copolymers from ISP Corporation under the trade name GANTREZ Available. When present, the anionic polycarboxylate is used in an amount effective to achieve the desired efficacy of any antimicrobial, anticalculus or other active agent in the dentifrice composition. In various embodiments, the synthetic anionic polycarboxylate contained in the oral composition is present in an amount of from 0.001 to 5% or from 0.1 to 2.0% of the oral composition.

The oral compositions of the present invention can be prepared by combining the ingredients by any of the methods known in the art to produce oral care compositions. Examples of methods that can be used are set forth in U.S. Patent No. 6,403,059 to Martin et al.; Clinical Pharmacology for Dental Professionals (Mosby-Year Book, Inc., 3rd edition 1989); Mosby's Dental Hygiene: Concepts, Cases and Competencies (Daniel) , S. and Harfst, S. eds., Elsevier Science Health Science Div. 2002); and Ernest W. Flick, Cosmetic and Toiletry Formulations, 2nd edition.

The present invention provides a method and process for using the oral compositions of the present invention to clean and/or polish an oral surface. In addition, the oral composition treats and inhibits oral symptoms such as stomatological symptoms, dental plaque, and calculus as appropriate. The oral composition can be applied to the patient in any suitable manner known in the art; for example, by using a suitable applicator or delivery device, such as a brush, a strip, a film, a syringe, a tape, a pill, or any of the techniques known in the art. Other applicators or delivery devices introduce the oral composition into the patient's mouth. The composition can be used in prophylactic methods and procedures to promote and maintain oral health, appearance, overall health, and the like. The oral composition can be repeatedly applied to the patient for more than a few days according to a special treatment schedule to treat and/or inhibit the formation of stains, plaque, stones or tartar. An operational guide for a treatment plan can be provided for commercial packaging, such as commercial preparation and storage.

Without intending to be bound by theory, it is believed that the ceria abrasive used in the oral compositions of the present invention has an initial average particle size. When the oral composition of the present invention is used to brush soft tissue, such as to remove plaque or film, the cerium oxide abrasive is sufficient to remove the soft tissue from, for example, the tooth surface. Thus, the oral composition initially has high PCR. However, when the cerium oxide abrasive particles are in contact with a hard tooth surface such as a dentin or tannin, they break into smaller particles; thereby resulting in low RDA. Therefore, when the composition of the present invention is used for treating the oral cavity, the soft tissue has been peeled off and the hard tissue is prevented from being worn. It is believed that when the composition is applied to the mouth, PCR and/or RDA can reduce both values over time due to the reduced size of the cerium oxide abrasive.

The resulting broken ceria particles resulting from contact with a hard surface also give an unexpected advantage; that is, the ability to polish the surface of the tooth and/or block the dental tubule, resulting in cleaner teeth and/or reduced tooth sensitivity. . Thus, the compositions of the present invention result in improved cleansing, polishing, and reduced tooth sensitivity.

The invention is further illustrated by the following non-limiting examples.

Example 1

The characteristics of cerium oxide A and cerium oxide B are determined as follows. Ceria A is Grace VP5. Ceria B is ZEODENT from JM Huber (Havre de Grace, Maryland, USA) 105.

The conditions used in the Einhleiner test were performed using a brass mesh and 100 g of cerium oxide at 1000 mL for 120 minutes and 174,000 revolutions. The oil absorption and average particle size are measured by methods known to those skilled in the art. The measurement system is presented in Table 1.

A 20% w/w slurry was prepared using deionized water with cerium oxide A and B. The particle size distribution of the initial slurry was determined using a Hydro 2000S small volume automated sample dispersion unit on a Malvern 2000 particle size analyzer. The slurry was sonicated in a water bath for 1 minute before the measurement to break any large cohesive polymer. Using a platform crossbar brush, add 20 ml of slurry to a sidewall 70° measurement Aluminum trough. A soft square head bristle brush (head size approximately length x width 2.8 cm x 1.0 cm) was placed to move along the entire aluminum trough base. The weight was added to the back of the brush head (250 grams) to create a positive force during brushing. The brushing machine runs at a rate of 100 doublings per minute along the aluminum surface for a total of 300 strokes. After brushing, the slurry was removed from the tank substrate and sonicated for 1 minute. The sample was loaded into a Malvern 2000 particle size analyzer. The cerium oxide abrasive particle size was then determined and presented in Table 2.

Table 2

Surprisingly, the results indicate the ability of cerium oxide A to significantly destroy during brushing regimen, while cerium oxide B remains relatively unchanged.

Example 2

The PCR and RDA values of various cerium oxide A slurries are determined by the methods previously described herein. The 10%, 15%, 20%, and 30% w/w cerium oxide slurries were prepared, and their PCR and RDA values were determined by the methods previously described herein. The results are presented in Table 3.

Example 3

A dentifrice composition such as a toothpaste was prepared according to Table 4.

Example 4

The two groups of 30 people who were sensitive to teeth were given toothpaste MF-A or MF-B, and indicated that the composition was used as its sole tooth powder for one month according to its normal brushing habit. At the end of the month, 75% of people brushed with MF-A reported reduced tooth sensitivity, and 10% of people brushed with MF-B reported reduced tooth sensitivity. At the end of the month, 3% of people brushed with MF-A reported increased tooth sensitivity, and 15% of people brushed with MF-B reported increased tooth sensitivity.

Example 5

Tooth cream WD-A or WD-B was administered to 50 groups of 50 people, and the composition was used as its sole tooth powder for one month according to its normal brushing habit. 80% of people who brushed their teeth with WD-A reported that they observed a whitening/buffing effect, while 5% of those who brushed their teeth with WD-B reported that they observed a whitening/buffing effect.

Example 6

Tooth smokers MF-A or MF-B were given to 15 groups of 15 smokers (average 1.4 packs per day) and indicated that the composition was used as their sole tooth powder according to their normal brushing habits. At the end of the month, 85% of people brushed with MF-A noticed a decrease in their stains, and 12% of those brushed with MF-B noticed a decrease in their stains.

Example 7

The RDA and PCR values of the two compositions comprising 20% cerium oxide A and 20% cerium oxide B were determined by the methods previously described herein. The two compositions are substantially identical except for the different cerium oxide abrasives. The results are presented in Table 5.

Claims (14)

An oral composition comprising an orally acceptable carrier; a cerium oxide abrasive comprising from 1% to 95% by weight of the composition, the cerium oxide abrasive comprising an average particle size of from 8 μm to 11 μm, An Einlehner hardness of 5 to 10 at 174,000 revolutions, and a d ₁₀ cerium oxide compound of 2.3 μm to 2.6 μm, and having an oil absorption of 70 cc/100 g to 110 cc/100 g; a fluoride ion source including a fluorination selected from Tin (II), sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluoroantimonate, ammonium fluoroantimonate, amine fluoride, ammonium fluoride fluoride, and combinations thereof fluoride salts; surfactants , which is selected from the group consisting of sodium lauryl sulfate, cocoamidopropyl betaine, and combinations thereof; a humectant selected from the group consisting of glycerin, sorbitol, and combinations thereof; and a polymer selected from the group consisting of polyethylene glycol and polyethylene. a methyl ether maleic acid copolymer, a polysaccharide, and a combination thereof; and an antibacterial agent selected from the group consisting of halogenated diphenyl ether, herbal extract or essential oil, biguanide preservative, quaternary ammonium compound, phenol Preservatives, hexetidine, povidone iodine, and dimoprostol ), salifluor, metal ion, blood root base, honeycomb wax, and oxygenating agent; wherein the average particle size of the cerium oxide abrasive is reduced by 16% to 20% after application to a hard surface in the oral cavity; The oral composition has a film clean ratio of 90 to 95, radioactive dental wear of 100 to 120, and a film clean ratio (PCR) / radioactive tooth wear (RDA) ratio of 0.8 to 1. The composition of claim 1, wherein the ceria abrasive is broken when the oral composition is applied to a hard surface in the oral cavity. The composition of claim 1, wherein the oral composition is brushed on the teeth for at least 30 seconds to 5 minutes. The composition of claim 1 wherein the d _{10 of} the ceria abrasive is reduced by 9% to 12% after application to a hard surface in the oral cavity. The composition of claim 1 of the patent scope includes a tooth desensitizer. For example, the composition of claim 1 includes a tooth whitening compound. The composition of claim 1 is a toothpaste or gel. The composition of claim 1, wherein the composition is applied to a surface of 1 to 10 cm ² by using a slurry comprising 1 to 5 ml of the oral composition; the surface is contacted with teeth irradiated by ³² P; A constant force of 5 Newtons wipes the tooth surface 300 strokes, wherein each stroke causes the surface to move 1 to 10 cm ² of the tooth; and a method of measuring the radioactive tooth wear (RDA) value. A composition according to claim 8 wherein the radioactive tooth wear (RDA) of the oral composition for 5 seconds in the oral cavity is 1.2 to 1.6 times the radioactive tooth of the same composition in the oral cavity for 1 to 5 minutes. Wear (RDA). For example, the composition of claim 1 of the patent range, wherein the Einlehner hardness is measured by a brass mesh every 174,000 revolutions. The composition of claim 10, wherein the Einlehner hardness is measured by a brass mesh per 100,000 revolutions. The composition of claim 1, wherein the 10% aqueous slurry consisting of cerium oxide abrasive has a film cleanup ratio (PCR) of 65 to 80. The composition of claim 1, wherein the 10% aqueous slurry consisting of cerium oxide abrasive has a radioactive tooth wear (RDA) of 75 to 91. The composition of claim 1, wherein the 10% aqueous slurry consisting of cerium oxide abrasive has a film cleanup ratio (PCR) / radioactive tooth wear (RDA) ratio of 0.7 to 0.9.