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TWI474842B - Modified powder and modified powder appearance and / or taste of the method - Google Patents

Modified powder and modified powder appearance and / or taste of the method Download PDF

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TWI474842B
TWI474842B TW102128512A TW102128512A TWI474842B TW I474842 B TWI474842 B TW I474842B TW 102128512 A TW102128512 A TW 102128512A TW 102128512 A TW102128512 A TW 102128512A TW I474842 B TWI474842 B TW I474842B
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powder
taste
appearance
modifying
berberine
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TW201505664A (en
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Nat Univ Chung Hsing
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Description

經修飾之粉末及修飾粉末外觀及/或味道之方法Modified powder and method for modifying the appearance and/or taste of the powder

本發明係有關於一種味道遮蔽之方法,特別係指一種經修飾之粉末及修飾粉末外觀及/或味道之方法。The present invention relates to a method of masking a taste, and more particularly to a modified powder and a method of modifying the appearance and/or taste of the powder.

按,苦味及澀味乃係普遍難被接受之味道,該兩種味道雖非常存在於各種食物中,惟,卻常出現於口服藥品或健康食品中,而當藥物或食品所具有之不悅味道越明顯,其則越容易被服藥者或消費者所排斥。因此,目前已開發出數種掩蓋不悅味道之技術,用以提高具有苦澀味道或不良氣味之藥品及健康食品被民眾之接受度。According to the taste, bitterness and astringency are generally unacceptable tastes. Although these two flavors are very common in various foods, they are often found in oral or health foods, and when drugs or foods are unpleasant. The more pronounced the taste, the easier it is to be rejected by the drug user or consumer. Therefore, several techniques for masking unpleasant taste have been developed to improve the acceptance of medicines and health foods having a bitter taste or a bad smell.

更進一步來說,習用掩蓋味道之方法係常藉由添加痲痺劑而麻痺食用者之味蕾,用以降低食用者感受不悅味道之敏感度,達到遮蔽味道之效果。此種方法雖然得使食用者味蕾於短期間內無法感受到苦澀味,然由於無法僅麻痺感受苦澀味之味蕾,故同時會影響到食用者對於其他味道之感受力。另有利用離子交換樹脂或是環形糊精等遮蔽方法,直接吸附或包埋苦味物質,用以達到遮蔽味道之功效,惟,由於製造過程中須將素材分散或溶於液相有機溶劑中始能進行,除於素材分散不均勻之情況下,造成遮蔽味道之效果不佳外,更由於使用有機溶劑若殘留於食品或藥品上,則對於食用安全產生較高風險,以及增加廠商進行溶劑回收之成本。Furthermore, the method of masking the taste is often to numb the taste bud of the consumer by adding a numbing agent, so as to reduce the sensitivity of the consumer to feel the unpleasant taste, and to achieve the effect of masking the taste. Although this method has to make the taste buds of the consumer unable to feel the bitter taste in a short period of time, since it is not possible to only feel the bitter taste buds, it also affects the taste of the consumer for other tastes. In addition, an ion exchange resin or a cyclodextrin or the like is used to directly adsorb or embed a bitter substance to achieve the effect of masking the taste, but the material must be dispersed or dissolved in the liquid organic solvent during the manufacturing process. In addition to the uneven dispersion of the material, the effect of masking the taste is not good, and if the use of organic solvents remains on the food or medicine, it poses a higher risk to food safety and increases the solvent recovery of the manufacturer. cost.

另有習用掩蓋味道之方法係藉由熔融包覆法進行味道遮 蔽,如台灣專利公告第I367767號「改善惡味之被覆製劑之製法」或公告第503114號「粒劑及其製法」中所揭者,即透過油性物質或蠟狀物質於熱形成熔融態所產生之黏性,而進行熱熔融包覆,惟,此種方法係僅能適用於非親水性物質。此外,習用掩蓋味道之方法係僅能針對大粒徑之物質進行包覆,如台灣專利申請第099139510號「遮蔽中藥味丸粒及其製法」,而對於粉末狀物質由於粒徑過小,無法直接包覆掩蓋味道之外層,則以混合如甘味劑之物質進行重新造粒,用以遮掩粉末狀物質於口中所產生之不良味道,如台灣專利申請第96139925號「遮蔽苦味之經口固形組合物」,然而所獲得之組成物之粒徑已增加,而增加食用者口服之難度。Another method of masking the taste is to cover the taste by melt coating. For example, in the case of Taiwan Patent Publication No. I367767 "Preparation of a coated preparation for improving bad taste" or the publication No. 503114 "Sizing agent and its preparation method", it is formed by melting an oily substance or a waxy substance in a molten state. The resulting viscosity is thermally melt coated, but this method is only applicable to non-hydrophilic substances. In addition, the method of masking the taste is only capable of coating a substance having a large particle size, such as the Taiwan Patent Application No. 099139510 "shading the Chinese medicine flavor pellet and its preparation method", and the powdery substance is too small to be directly Covering the outer layer of the taste, re-granulation is carried out by mixing a substance such as a sweetener to mask the bad taste of the powdery substance in the mouth. For example, Taiwan Patent Application No. 96139925 "Blocking oral solid composition" However, the particle size of the obtained composition has increased, which increases the difficulty for the oral administration of the consumer.

由上可知,習用技術所揭內容係除皆需透過不同化學物質進行,提高食品或藥物安全之風險,且無法直接針對粉末狀物質進行味道遮掩,因而侷限其所能使用之範圍。因此,開發出一種僅須使用天然素材並得直接用於粉末狀物質之掩味方法,乃係為目前食品及醫藥產業之重要課題。As can be seen from the above, the contents of the conventional technology are all required to be carried out through different chemical substances to improve the risk of food or drug safety, and it is not possible to directly cover the taste of the powdery substance, thereby limiting the range in which it can be used. Therefore, the development of a taste masking method which only requires the use of natural materials and is directly used for powdery substances is an important subject in the current food and pharmaceutical industry.

因此,本發明之主要目的乃在於提供一種修飾粉末外觀及/或味道之方法,係包含有以下步驟:(a)取一粉粒;(b)取一包覆物,與該粉粒均勻混合,而附著於該粉粒表面,其中,該包覆物係為醣類;(c)該包覆物於一預定溫度及濕度之環境下藉由水合反應而逐漸於該粉粒表面形成一薄膜; (d)進行乾燥,使該薄膜固定於該粉粒表面;(e)獲得一經修飾之粉末。Accordingly, it is a primary object of the present invention to provide a method of modifying the appearance and/or taste of a powder comprising the steps of: (a) taking a powder; (b) taking a coating and uniformly mixing the powder. And adhering to the surface of the powder, wherein the coating is a sugar; (c) the coating gradually forms a film on the surface of the powder by a hydration reaction under a predetermined temperature and humidity environment. ; (d) drying to fix the film to the surface of the powder; (e) obtaining a modified powder.

其中:among them:

該步驟a之該粉粒表面係具有水分子,具體來說,其係藉由將該粉粒置於水浴槽中,而使該粉粒表面具有水分子。The surface of the powder of the step a has water molecules, and specifically, the powder particles have water molecules on the surface thereof by placing the particles in a water bath.

該步驟b之該包覆物係選自由澱粉、澱粉衍生物及含有上述成份之組合物,具體來說,該包覆物係得為麥芽糊精,或為糖粉,或為由麥芽糊精及食用膠以一預定比例所組成之一組合物,其中,該組合物中食用膠之含量係不大於35%。The coating of the step b is selected from the group consisting of starch, a starch derivative and a composition containing the above ingredients, specifically, the coating is obtained as maltodextrin, or as a powdered sugar, or as a malt. The composition of the dextrin and the edible gum in a predetermined ratio, wherein the content of the edible gum in the composition is not more than 35%.

步驟a中之該粉粒係得由食物、食品組成份或藥材所製備而成者,如葡萄糖、黃連等,而該粉粒之粒徑係介於30~800μm。The powder in the step a is prepared from food, a food component or a medicinal material, such as glucose, berberine, etc., and the particle size of the powder is between 30 and 800 μm.

步驟b之該包覆物之粒徑係介於為1~80μm,又以粒徑為1~15μm較佳。The coating material of the step b has a particle diameter of from 1 to 80 μm, and preferably has a particle diameter of from 1 to 15 μm.

步驟c中之該預定溫度係為45~150℃,又以該預定溫度係為60~100℃較佳;而該預定濕度係為90~100%。The predetermined temperature in the step c is 45 to 150 ° C, and the predetermined temperature is preferably 60 to 100 ° C; and the predetermined humidity is 90 to 100%.

本發明所揭修飾粉末外觀及/或味道之方法,於本發明之實施例中,更可包含一步驟d1,介於該步驟d與該步驟e間,將步驟d所得之物重複進行步驟b至步驟d至少一次。而於重複步驟b時,所使用之該包覆物係得不同於第一次所使用之該包覆物。The method for modifying the appearance and/or taste of the powder in the present invention may further comprise a step d1 between the step d and the step e, and repeating the step b to repeat the step b. Go to step d at least once. When the step b is repeated, the coating used is different from the coating used for the first time.

藉由本發明所揭修飾粉末外觀及/或味道之方法,其可將純天然素材形成一薄膜而包覆於欲被修飾之粉粒外層,用以延遲或阻隔該粉粒於溶液中溶出,達到苦味遮蔽、味道修飾、調整顏色以及增加保存性等 功效。換言之,藉由本發明所揭修飾粉末外觀及/或味道之方法所製得之經修飾之粉末係可被改善原有粉粒之色、香、味及保存性,而更能被食用者或消費者所接受。The method for modifying the appearance and/or taste of a powder according to the present invention, wherein a pure natural material is formed into a film and coated on the outer layer of the powder to be modified to delay or block the dissolution of the powder in the solution. Bitterness, taste modification, color adjustment, and preservation efficacy. In other words, the modified powder obtained by the method of modifying the appearance and/or taste of the powder of the present invention can improve the color, aroma, taste and preservability of the original powder, and can be more consumed by consumers or consumers. Accepted by the people.

(10)(10’)‧‧‧修飾粉末外觀及/或味道之方法(10) (10') ‧‧‧Methods for modifying the appearance and/or taste of powders

(20)‧‧‧黃連粉粒(20) ‧‧‧Coptis powder

(30)‧‧‧水分子(30) ‧ ‧ water molecules

(40)‧‧‧澱粉(40)‧‧‧ Starch

(50)‧‧‧薄膜(50) ‧‧‧film

(60)‧‧‧經修飾之黃連粉粒(60)‧‧‧Modified berberine powder

第一圖係為本發明第一較佳實施例之流程圖。The first figure is a flow chart of a first preferred embodiment of the present invention.

第二圖係為本發明第一較佳實施例之示意圖。The second drawing is a schematic view of a first preferred embodiment of the present invention.

第三圖係為本發明第五較佳實施例之流程圖。The third figure is a flow chart of a fifth preferred embodiment of the present invention.

第四圖係為未經包覆之黃連粉粒。The fourth picture is the uncoated berberine powder.

第五圖A係以電子顯微鏡顯示未經包覆之黃連粉粒。Figure 5A shows the uncoated berberine powder by electron microscopy.

第五圖B至D係以電子顯微鏡顯示澱粉進行包覆黃連粉粒之過程。The fifth figure B to D shows the process of coating the coptis powder with starch by electron microscopy.

第五圖E係以電子顯微鏡顯示黃連粉粒表面已包覆有澱粉薄膜之結果。Figure 5 is a result of electron microscopy showing that the surface of the berberine powder has been coated with a starch film.

第六圖係以電子顯微鏡顯示表面具有澱粉薄膜之黃連粉粒之切面。The sixth figure shows the cut surface of the berberine powder having a starch film on the surface by an electron microscope.

第七圖係為具不同數量澱粉薄膜之黃連粉粒於一分鐘內之黃連素釋出比率。The seventh figure shows the release ratio of berberine in one minute from the berberine powder with different amounts of starch film.

第八圖係為具不同數量澱粉薄膜之葡萄糖粉粒於一分鐘內之葡萄糖釋出比率。The eighth figure is the glucose release ratio of glucose granules with different amounts of starch film in one minute.

第九圖係為被麥芽糊精包覆於表面之黃連粉粒。The ninth picture shows the berberine powder coated on the surface by maltodextrin.

第十圖A係為粒徑約55μ m之黃連粉粒於包覆前以電子顯微鏡觀察之結果。The tenth figure A is the result of observation of the berberine powder having a particle diameter of about 55 μm by electron microscopy before coating.

第十圖B係為粒徑約130μ m之黃連粉粒於包覆前以電子顯微鏡觀察之結果Figure 10B shows the results of observation by electron microscopy of berberine powder with a particle size of about 130 μm before coating.

第十圖C係為粒徑約430μ m之黃連粉粒於包覆前以電子顯微鏡觀察之結果Figure 10C shows the results of observation by electron microscopy of berberine powder with a particle size of about 430 μm before coating.

第十圖D係以電子顯微鏡顯示粒徑約55μ m之黃連粉粒經麥芽糊精包覆後之結果。Fig. D is the result of electron microscopy showing that the berberine powder having a particle size of about 55 μm is coated with maltodextrin.

第十圖E係以電子顯微鏡顯示粒徑約130μ m之黃連粉粒經麥芽糊精包覆後之結果。Fig. E is the result of electron microscopy showing that the berberine powder having a particle size of about 130 μm is coated with maltodextrin.

第十圖F係以電子顯微鏡顯示粒徑約430μ m之黃連粉粒經麥芽糊精包覆後之結果。Fig. F is the result of electron microscopy showing that the berberine powder having a particle size of about 430 μm is coated with maltodextrin.

第十一圖係為具不同數量麥芽糊精薄膜之黃連粉粒於一分鐘內之黃連素釋出比率。The eleventh figure shows the release ratio of berberine in one minute from the Coptidis powder with different amounts of maltodextrin film.

第十二圖A係以電子顯微鏡顯示未經糖粉包覆之黃連粉粒。Fig. 12A shows the coptis powder coated with no sugar powder by an electron microscope.

第十二圖B係以電子顯微鏡顯示糖粉於黃連粉粒表面形成薄膜之結果。Fig. 12B shows the results of forming a film on the surface of the berberine powder by means of an electron microscope.

本發明所揭修飾粉末外觀及/或味道之方法,其係藉由使一包覆物藉由水合反應,而於一粉末狀物質表面形成一薄膜,用以遮掩該粉末狀物質原有之不悅味道、不佳氣味或不良外觀,或是用以增加該粉末狀物質之保存性。The method for modifying the appearance and/or taste of a powder of the present invention comprises: forming a film on the surface of a powdery substance by hydrating a coating to cover the original powdery substance. A pleasant taste, a bad smell or a bad appearance, or used to increase the preservation of the powdery substance.

其中,本發明中所謂之粉末狀物質,係來自於一般常見之食材、食品組成份或是中草藥,如葡萄糖、黃連或帶有苦味之中草藥。Among them, the so-called powdery substance in the present invention is derived from commonly used foodstuffs, food components or Chinese herbal medicines such as glucose, berberine or a bitter-smelling herbal medicine.

本發明中所謂之澱粉,其分子式為(C6 H10 O5 )n ,含有支鏈澱粉及直鏈澱粉兩種成份,而該兩種成份之基本鏈結係為葡萄糖剩基。The starch in the present invention has a molecular formula of (C 6 H 10 O 5 ) n and contains both amylopectin and amylose, and the basic chain of the two components is a glucose residual group.

本發明中所謂之澱粉衍生物,係包含有修飾澱粉或澱粉經酵素水解後所得之產物,如麥芽糊精。The starch derivative in the present invention comprises a product obtained by hydrolyzing a modified starch or starch by an enzyme, such as maltodextrin.

本發明中所謂之食用膠,係可取自於植物、動物或微生物,如瓊脂、阿拉伯膠、刺梧桐膠、關華豆膠、塔拉膠、刺槐豆膠、糯米膠、果膠、海藻膠、鹿角菜膠、魚膠、明膠、洋干膠、玉米糖膠、結蘭膠、卡德蘭膠等。The so-called edible gum in the present invention can be obtained from plants, animals or microorganisms, such as agar, gum arabic, karaya gum, Guanhua bean gum, tara gum, locust bean gum, glutinous rice gum, pectin, seaweed gum. , carrageenan, fish gelatin, gelatin, dried apple, corn candy, yam, gelland and so on.

本發明中所謂水合反應,係指藉由水分子進入包覆物之分子間,用以使包覆物之各該分子重新藉由氫鍵相互連接,而形成一薄膜。The term "hydration reaction" as used in the present invention means that water molecules enter the molecules of the coating to form a film by rejoining each of the molecules of the coating by hydrogen bonding.

本發明中所謂經修飾,係包含有延緩或阻隔粉末狀物質之釋放效果或溶出速率,改變粉末狀物質原有顏色、亮度、光澤等視覺效果,改善或改變粉末狀物質原有氣味,以及增加粉末狀物質之保存性。The term "modified" in the present invention includes delaying or blocking the release effect or dissolution rate of the powdery substance, changing the original color, brightness, gloss and the like of the powdery substance, improving or changing the original odor of the powdery substance, and increasing Preservation of powdered materials.

上述對於本發明內容中之名詞說明,僅為一種例示性之說明,係非用以限制本發明說明書內容以及申請專利範圍。The above description of the terms in the present invention is merely illustrative and is not intended to limit the scope of the description of the invention and the scope of the claims.

為了更進一步說明,以下茲舉本發明若干較佳實施例並配合圖式說明如后。For further explanation, several preferred embodiments of the invention are set forth below and described in conjunction with the drawings.

請參閱第一圖及第二圖,本發明之第一較佳實施例所揭之修飾粉末外觀及/或味道之方法(10),包含有下列步驟:Referring to the first and second figures, the method (10) for modifying the appearance and/or taste of a powder disclosed in the first preferred embodiment of the present invention comprises the following steps:

步驟101:取一定量之黃連粉粒(20),其係藉由置於水浴槽而使各該黃連粉粒(20)表面佈滿水分子(30),呈現微溼潤狀態。Step 101: Take a certain amount of berberine powder (20), which is placed in a water bath to make the surface of each coptis powder (20) covered with water molecules (30), showing a slightly moist state.

步驟102:取將一定量之澱粉(40)與各該黃連粉粒(20) 均勻混合,使該澱粉附著於各該黃連粉粒表面(40)。Step 102: taking a certain amount of starch (40) and each of the berberine powder particles (20) The starch is uniformly mixed to adhere the surface of each of the copets (40).

步驟103:使該澱粉(40)於一預定溫度與濕度下藉由糊化反應,而逐漸於各該黃連粉粒(20)表面形成一薄膜(50)。Step 103: The starch (40) is gradually gelatinized at a predetermined temperature and humidity to form a film (50) on the surface of each of the coprin powder particles (20).

步驟104:以熱風進行乾燥,使該薄膜(50)定型於該黃連粉粒(20)表面。Step 104: Drying with hot air to shape the film (50) on the surface of the coptis powder (20).

步驟105:得到一經修飾之黃連粉粒(60)。Step 105: A modified berberine powder (60) is obtained.

其中:among them:

步驟101中之黃連粉粒之粒徑係介於30~800μm之間。The particle size of the berberine powder in the step 101 is between 30 and 800 μm.

步驟102中之澱粉粒徑介於1~80μm之間,又以1~15μm為較佳。The particle size of the starch in step 102 is between 1 and 80 μm, preferably 1 to 15 μm.

步驟104之預定溫度約為45~150℃,又以60~100℃為較佳,而該預定濕度係為90~100%。The predetermined temperature of step 104 is about 45 to 150 ° C, preferably 60 to 100 ° C, and the predetermined humidity is 90 to 100%.

須加以說明者,糊化反應乃為水合反應之一種,其係當澱粉於水分充足之環境下,透過溫度升高至糊化溫度以上,破壞澱粉分子間之氫鍵,使水分子得以進入澱粉分子間而產生水合,用以使澱粉糊化而致各澱粉分子間重新藉由氫鍵相互連接,待後續乾燥完成後,則得形成一緊實之薄膜。It should be noted that the gelatinization reaction is a kind of hydration reaction. When the starch is in a water-rich environment, the temperature rises above the gelatinization temperature, and the hydrogen bond between the starch molecules is destroyed, so that the water molecules can enter the starch. The molecules are hydrated to gelatinize the starch, and the starch molecules are rejoined by hydrogen bonds. After the subsequent drying is completed, a compact film is formed.

藉由本發明之第一較佳實施例所揭修飾粉末外觀及/或味道之方法,透過水分子作為黃連粉粒與澱粉間之黏合劑,使黃連粉粒表面均勻地佈滿澱粉,並且透過溫溼調控,使澱粉糊化形成薄膜,完全地包覆於黃連粉粒之表面,用以達到延緩黃連粉粒溶於溶液之時間。By the method of modifying the appearance and/or taste of the powder according to the first preferred embodiment of the present invention, the water molecules are used as a binder between the coptis powder and the starch, so that the surface of the coptis powder is evenly covered with starch, and the temperature is transmitted through the temperature. The wet regulation causes the starch to be gelatinized to form a film which is completely coated on the surface of the berberine powder to delay the dissolution of the coptis powder in the solution.

本發明之第二較佳實施例所揭之修飾粉末外觀及/或味道之 方法,其步驟大致於本發明第一較佳實施例相同,惟,不同在於係將澱粉改為麥芽糊精,而由於麥芽糊精係為澱粉低度水解產物,分子結構係較澱粉分子鬆散,氫鍵數量亦少於澱粉分子,因而係不以高溫破壞分子間之氫鍵,故該預定溫度可設為中低溫,並且藉由水合反應,使麥芽糊精分子重新藉由氫鍵相互連接,形成一聚集網狀結構(aggregation network),達成與本發明第一較佳實施例相同之功效。Modified powder appearance and/or taste of the second preferred embodiment of the present invention The method has the same steps as the first preferred embodiment of the present invention, except that the starch is changed to maltodextrin, and since the maltodextrin is a low-grade hydrolysis product of starch, the molecular structure is more than the starch molecule. Loose, the number of hydrogen bonds is also less than that of starch molecules, so the hydrogen bonds between the molecules are not destroyed by high temperature, so the predetermined temperature can be set to medium and low temperature, and the maltodextrin molecules are re-hydrogenated by hydration reaction. Interconnected to form an aggregate network, achieving the same effect as the first preferred embodiment of the present invention.

本發明之第三較佳實施例所揭之修飾粉末外觀及/或味道之方法,其步驟大致於本發明第二較佳實施例相同,惟,不同在於該包覆物係為由麥芽糊精及食用膠依據一預定比例所混合之組合物,其中,該組合物中食用膠之含量係不高於35%,亦得達成與本發明第二較佳實施例相同之功效。The method for modifying the appearance and/or taste of a powder disclosed in the third preferred embodiment of the present invention is substantially the same as the second preferred embodiment of the present invention, except that the coating is made of malt paste. The composition of the fine and edible gum is mixed according to a predetermined ratio, wherein the content of the edible gum in the composition is not more than 35%, and the same effect as the second preferred embodiment of the present invention is achieved.

本發明之第四較佳實施例所揭之修飾粉末外觀及/或味道之方法,其步驟大致於本發明第一較佳實施例相同,不同在於該包覆物係為糖粉,亦能達成與本發明第一較佳實施例相同之功效。The method for modifying the appearance and/or taste of a powder disclosed in the fourth preferred embodiment of the present invention is substantially the same as the first preferred embodiment of the present invention, except that the coating is a powdered sugar and can be achieved. The same effect as the first preferred embodiment of the present invention.

請參閱第三圖,本發明之第五較佳實施例所揭之修飾粉末外觀及/或味道之方法(10’),其包含下列步驟:Referring to the third figure, a method (10') for modifying the appearance and/or taste of a powder disclosed in a fifth preferred embodiment of the present invention comprises the following steps:

步驟501:取一定量之黃連粉粒,其係藉由置於水浴槽而使各該黃連粉粒表面佈滿水分子,呈現微溼潤狀態。Step 501: taking a certain amount of berberine powder, which is placed in a water bath to make the surface of each coptis powder full of water molecules, showing a slightly moist state.

步驟502:取將一定量之該包覆物與各該黃連粉粒均勻混合,使該澱粉附著於各該黃連粉粒表面,其中,該包覆物係為醣類而得為澱粉、澱粉衍生物或含有上述成份之組合物。Step 502: uniformly mixing a certain amount of the coating with each of the coptis powders, and attaching the starch to the surface of each coptis powder, wherein the coating is a saccharide and is obtained by starch or starch. Or a composition comprising the above ingredients.

步驟503:使該包覆物於一預定溫度與濕度下藉由水合反 應,而逐漸於各該黃連粉粒表面形成一薄膜。Step 503: causing the coating to be reversed by hydration under a predetermined temperature and humidity. A film is formed on the surface of each of the coptis powders.

步驟504:以熱風進行乾燥,使該薄膜定型於該黃連粉粒表面。Step 504: drying with hot air to shape the film on the surface of the coptis powder.

步驟505:將步驟504所得之產物重複步驟502至步驟504至少一次。Step 505: Repeat step 502 to step 504 for the product obtained in step 504 at least once.

步驟506:得到一經修飾之黃連粉粒。Step 506: A modified coptis powder is obtained.

藉由本發明第五較佳實施例所揭修飾粉末外觀及/或味道之方法,除可達成與上述各較佳實施例相同之功效外,係可增加該包覆物於黃連表面之薄膜數量,用以加強延緩欲包覆粉粒之溶出速率以及薄膜對於欲包覆粉粒之保護效果。此外,本發明所揭之方法係可依據需求,選擇性重複步驟502至504之次數,不僅可增加薄膜數量,更可藉由重複502步驟時選擇異於前次所使用之該包覆物種類,達到調整該粉粒色、香、味等目的。The method for modifying the appearance and/or taste of the powder by the fifth preferred embodiment of the present invention can increase the amount of the film on the surface of the coptis, in addition to the same effects as the above preferred embodiments. It is used to enhance the dissolution rate of the powder to be coated and the protective effect of the film on the particles to be coated. In addition, the method disclosed in the present invention can selectively repeat the number of steps 502 to 504 according to requirements, not only increasing the number of films, but also selecting the type of the coating used in the previous step by repeating step 502. To achieve the purpose of adjusting the color, fragrance and taste of the powder.

以下,更藉由若干實例及其圖式與數據驗證本發明所達成之功效。In the following, the effects achieved by the present invention are further verified by a number of examples and their schemas and data.

實例一:製備經澱粉修飾之黃連粉粒Example 1: Preparation of starch-modified berberine powder

取200公克、粒徑約55~500μm之黃連粉粒,如第四圖所示。將該黃連粉粒置於一水浴槽中,使該黃連粉粒表面佈滿水分子而略呈溼潤,並注入約85℃之熱風,且不間斷地進行攪拌。而後加入約10公克、粒徑1~10μm之澱粉,並使該澱粉與該黃連粉粒快速地均勻混合,用以使該澱粉附著於各該黃連粉粒上。持續注入熱風,使溫度維持於85℃,並且使濕度為90~95%,用以使該澱粉係進行糊化反應,各該澱粉分子間緊密 地連接,於各該黃連粉粒表面上形成一薄膜,同時透過熱風亦得避免使各該黃連粉粒表面具有過多水分子。重複上述加熱、調濕、乾燥等步驟一次,直至各該黃連粉粒完全地被由澱粉所形成之二層薄膜所包覆住,再以約85℃之熱風予以充分乾燥,而得到一經澱粉修飾之黃連粉粒。Take 200 grams of berberine powder with a particle size of about 55-500 μm, as shown in the fourth figure. The coptis powder was placed in a water bath, the surface of the coptis powder was covered with water molecules and slightly moistened, and hot air of about 85 ° C was injected, and stirring was continued without interruption. Then, about 10 grams of starch having a particle diameter of 1 to 10 μm is added, and the starch is rapidly and uniformly mixed with the coptis powder to adhere the starch to each of the coptis powder particles. Continuously injecting hot air, maintaining the temperature at 85 ° C, and making the humidity 90-95%, in order to make the starch system gelatinization reaction, each of the starch molecules is tight The ground connection forms a film on the surface of each of the berberine powder particles, and at the same time, the hot air is also prevented from having excessive water molecules on the surface of each of the coptis. Repeat the above steps of heating, humidity control, drying, etc. until the coptis powder is completely covered by the two-layer film formed by the starch, and then sufficiently dried by hot air at about 85 ° C to obtain a starch modified The berberine powder.

上述該經澱粉修飾之黃連粉粒之製備過程係以電子顯微鏡觀察,結果如第五圖A至E所示,其中,第五圖A係為未包覆之黃連粉粒,第五圖B至D係分別用以表現澱粉正在進行包覆黃連粉粒之過程,第五圖E係表現澱粉已完成包覆於黃連粉粒表面。該經澱粉修飾之黃連粉粒之切面以電子顯微鏡觀察所得之結果,如及第六圖所示。由第五圖及第六圖可知澱粉確實地可於黃連粉粒表面形成穩固之包覆層。The preparation process of the above-mentioned starch-modified berberine powder is observed by an electron microscope, and the results are as shown in FIG. 5A to FIG. E, wherein the fifth figure A is an uncoated berberine powder, and the fifth figure B is The D system is used to express the process of starch coating the coptis powder. The fifth figure E shows that the starch has been coated on the surface of the berberine powder. The cut surface of the starch-modified berberine powder was observed by an electron microscope as shown in the sixth graph. It can be seen from the fifth and sixth figures that the starch can form a stable coating on the surface of the berberine powder.

實例二:黃連素釋放試驗Example 2: Berberine release test

由於食物於口中滯留時間約為0.5~1分鐘,意即能夠感受到味道之時間係為1分鐘以內,因此,本實例係以實例一所揭之方法製備含有不同數量澱粉薄膜之黃連粉粒,並以黃連素作為味覺物質之指標成份,浸泡於蒸餾水中,檢測黃連粉粒於溶液中之釋放效率,用以證明澱粉薄膜係具有阻隔並延緩味覺成分的釋放效果。Since the residence time of the food in the mouth is about 0.5 to 1 minute, that is, the time when the taste can be felt is within 1 minute. Therefore, in this example, the coptis powder containing different amounts of starch film is prepared by the method disclosed in Example 1. The berberine is used as an indicator component of the taste substance, soaked in distilled water to detect the release efficiency of the berberine powder in the solution, to prove that the starch film has the barrier and delay the release of the taste component.

詳言之,藉由實例一之方法分別製備完成之具有一層澱粉薄膜、二層澱粉薄膜及三層澱粉薄膜之黃連粉粒,各該黃連粉粒係含有331.06毫克黃連素,分別浸泡於於37℃之100毫升蒸餾水中,並持續攪拌。另取未包覆任何澱粉之黃連粉粒作為對照組。而分別於2、30、60秒時吸取各該黃連水溶液,以高效能液相層析法(HPLC)進行黃連素之定量分析;另高效能液相層析法係以1mL/min流速沖提,移動相分別為由25mM、酸鹼值 2.5之磷酸二氫鈉(NaH2 PO4 )組成之溶劑A,以及由乙腈(acetonitrile)所組成之溶劑B。其間係以254nm監控,梯度流析條件先以溶劑A:溶劑B之比例為70:30(v/v)作為起始沖提比例,並在15分鐘內以線性梯度拉至100%溶劑B,隨後在10分鐘內再將溶劑A/溶劑B之比例拉回70:30(v/v),其滯留時間約為7.1~7.3分鐘,注射量為20μL。最後將所測得之波鋒面積,依標準曲線換算成各該黃連粉粒中黃連素之濃度含量,結果如下表一及第七圖所示。再者,更進一步計算出具有不同數量澱粉薄膜之各該黃連粉粒以及未包覆之黃連粉粒於水溶液中1分鐘內之黃連素平均釋放速率,結果如下表二所示。In detail, the coptis powder having a starch film, a two-layer starch film and a three-layer starch film prepared by the method of Example 1 each contains 33.106 mg of berberine, respectively, and is immersed in 37 Centrifuge in 100 ml of °C and keep stirring. Another coptis powder which was not coated with any starch was used as a control group. The aqueous solution of Coptis was taken at 2, 30, and 60 seconds, respectively, and the quantitative analysis of berberine was performed by high performance liquid chromatography (HPLC). The high performance liquid chromatography was eluted at a flow rate of 1 mL/min. The mobile phase was respectively solvent A consisting of 25 mM, sodium dihydrogen phosphate (NaH 2 PO 4 ) having a pH of 2.5, and solvent B consisting of acetonitrile. In the meantime, it was monitored at 254 nm. The gradient analysis conditions were as follows: solvent A: solvent B ratio of 70:30 (v/v) as the initial extraction ratio, and pulled to 100% solvent B in a linear gradient within 15 minutes. The ratio of solvent A/solvent B was then pulled back to 70:30 (v/v) over 10 minutes with a residence time of about 7.1 to 7.3 minutes and an injection volume of 20 μL. Finally, the measured wave front area is converted into the concentration content of berberine in each of the coptis powders according to the standard curve. The results are shown in Tables 1 and 7 below. Furthermore, the average release rate of berberine in each of the aqueous solution of the Coptidis powder having different amounts of starch film and the uncoated P. chinensis powder in one minute was further calculated, and the results are shown in Table 2 below.

由表一、表二及第七圖之結果可知,未包覆之黃連粉粒於2秒時係測得47.73毫克之黃連素,溶出率為14.42%,於30秒時,黃連素濃 度急速增高,所測得之黃連素係為261.15毫克,溶出率為78.88%,而於60秒時,已接近完全溶出,釋放出295.35毫克之黃連素,溶出率為89.21%,整體來說,黃連素之平均釋放速率為每秒4.92毫克;而包覆一層澱粉薄膜之黃連粉粒於2秒、30秒及60秒所測得之黃連素克數分別為7.25、46.00和86.26毫克,且浸泡一分鐘後,溶出率係不超過30%,黃連素之平均釋放速率為每秒1.44毫克;包覆二層澱粉薄膜之黃連粉粒於2秒、30秒及60秒所測得之黃連素克數分別為1.41、37.45和54.11毫克,溶出率分別為0.42%、11.31%、16.35%,於一分鐘內黃連素之平均釋放速率為每秒0.90毫克;包覆三層澱粉薄膜之黃連粉粒於2秒時所測得之黃連素濃度為0.54毫克,溶出率為0.16%,而後分別於30秒及60秒測得之黃連素克數為8.55及21.43毫克,溶出率分別為2.58%及6.47%,於一分鐘內黃連素之平均釋放速率為每秒0.36毫克。From the results of Table 1, Table 2 and Figure 7, it can be seen that the uncoated berberine powder measured 47.73 mg of berberine at 2 seconds, and the dissolution rate was 14.42%. At 30 seconds, berberine was concentrated. The rapid increase, the measured berberine was 261.15 mg, the dissolution rate was 78.88%, and at 60 seconds, it was nearly completely dissolved, releasing 295.35 mg of berberine, the dissolution rate was 89.21%, overall, The average release rate of berberine was 4.92 mg per second; and the berberine gram counts of berberine powder coated with a starch film at 2, 30 and 60 seconds were 7.25, 46.00 and 86.26 mg, respectively, and soaked. After one minute, the dissolution rate is no more than 30%, the average release rate of berberine is 1.44 mg per second; and the berberine gram of the berberine powder coated with the two-layer starch film at 2 seconds, 30 seconds, and 60 seconds The numbers were 1.41, 37.45 and 54.11 mg, respectively, and the dissolution rates were 0.42%, 11.31%, and 16.35%, respectively. The average release rate of berberine was 0.90 mg per second in one minute; the berberine powder coated with three layers of starch film was The concentration of berberine measured at 2 seconds was 0.54 mg, the dissolution rate was 0.16%, and the berberine grams measured at 30 seconds and 60 seconds were 8.55 and 21.43 mg, respectively, and the dissolution rates were 2.58% and 6.47%, respectively. , the average release rate of berberine in one minute is 0.36 milliseconds per second. Gram.

由上述結果可知相較於未包覆之黃連粉粒,具有澱粉薄膜之黃連粉粒於各該時間點所測得之黃連素克數係顯著降低,顯示澱粉薄膜確實能夠有效地阻隔及延緩黃連素於水溶液中釋出,達到味道修飾之目的。再者,透過增加澱粉薄膜數量,可加強延緩黃連素之溶出速率,如具有二層澱粉薄膜之黃連粉粒於30秒所釋出之黃連素濃度較2秒時提高10.89%,而具有三層澱粉薄膜之黃連粉粒於30秒所釋出之黃連素濃度較2秒時僅提高2.42%。From the above results, it can be seen that compared with the uncoated berberine powder, the berberine gram count of the berberine powder having the starch film at each time point is significantly reduced, indicating that the starch film can effectively block and delay the berberine. It is released in an aqueous solution to achieve the purpose of taste modification. Furthermore, by increasing the amount of starch film, the dissolution rate of berberine can be enhanced, such as the berberine concentration released by the two-layer starch film in 30 seconds is 10.89% higher than that at 2 seconds, and has three layers. The concentration of berberine released from the starch film of Coptis chinensis in 30 seconds was only 2.42% higher than that at 2 seconds.

實例三:葡萄糖釋放試驗Example 3: Glucose release test

於本實例中係採取如實例一之方式,分別製備具有一層澱粉薄膜之葡萄糖粉粒、具有二層澱粉薄膜之葡萄糖粉粒以及具有三層澱粉薄 膜之葡萄糖粉粒。In the present example, a glucose powder having a starch film, a glucose powder having a two-layer starch film, and a three-layer starch thinner are separately prepared as in the first embodiment. Membrane glucose powder.

將以包覆有不同數量澱粉薄膜之各該葡萄糖粉粒與未包覆之葡萄糖粉粒,而各該葡萄糖粉粒含有311.02毫克葡萄糖。將各該葡萄糖係分別依據實例二之步驟進行葡萄糖釋放試驗,並以葡萄糖測定試劑盒(Glucose GOD-PAP kit,由Fortress diagnostics公司製造)快速分析葡萄糖定量,結果如第八圖及表三所示。此外,更進一步計算出具有不同數量澱粉薄膜之各該葡萄糖粉粒以及未包覆澱粉薄膜之葡萄糖粉粒於水溶液中1分鐘內之葡萄糖平均釋放速率,結果如下表四所示。Each of the glucose powder particles coated with a different amount of starch film and the uncoated glucose powder particles each containing 311.02 mg of glucose. Each glucose system was subjected to a glucose release test according to the procedure of Example 2, and the glucose assay was rapidly analyzed by a glucose assay kit (Glucose GOD-PAP kit, manufactured by Fortress Diagnostics Co., Ltd.), and the results are shown in FIG. 8 and Table 3. . Further, the average release rate of glucose in each of the glucose granules having different amounts of the starch film and the uncoated starch film in one minute was further calculated, and the results are shown in Table 4 below.

由表三、表四及第八圖之結果可知,未包覆之葡萄糖粉粒於2秒時係測得8.28毫克之葡萄糖,溶出率2.66%,於30秒時,葡萄糖濃度急速地增高,所測得之量為82.44毫克,溶出率為26.50%,而於60秒時係測 得184.68毫克之葡萄糖,溶出率為59.37%,整體來說,葡萄糖平均釋放速率為每秒3.08毫克;而包覆上一層澱粉保護膜之該葡萄糖粉粒於2秒、30秒及60秒所測得之葡萄糖克數分別為6.55、69.52和143.93毫克,葡萄糖平均釋放速率係為每秒2.40毫克;具有二層保護膜之該葡萄糖粉粒於2秒時所測得之葡萄糖係為2.38毫克,溶出率為0.77%,於30秒係測得38.93毫克之葡萄糖,溶出率為12.51%,於60秒時所測得之葡萄糖為97.38毫克,溶出率31.30%,而葡萄糖平均釋放速率延緩為每秒1.62毫克;具有三層保護膜之該葡萄糖粉粒於2秒、30秒及60秒所測得之葡萄糖分別為1.07、27.62及70.71毫克,溶出率分別為0.34%、8.88%及22.73%,而葡萄糖平均釋放速率則為每秒1.18毫克。From the results of Table 3, Table 4 and Figure 8, it can be seen that the uncoated glucose powder measured 8.28 mg of glucose at 2 seconds, and the dissolution rate was 2.66%. At 30 seconds, the glucose concentration rapidly increased. The measured amount was 82.44 mg, the dissolution rate was 26.50%, and it was measured at 60 seconds. 184.68 mg of glucose, the dissolution rate was 59.37%. Overall, the average release rate of glucose was 3.08 mg per second; and the glucose powder coated with a starch protective film was measured at 2 seconds, 30 seconds and 60 seconds. The grams of glucose were 6.55, 69.52 and 143.93 mg, respectively, and the average release rate of glucose was 2.40 mg per second. The glucose powder with a two-layer protective film measured 2.38 mg of glucose at 2 seconds. The rate was 0.77%, 38.93 mg of glucose was measured at 30 seconds, the dissolution rate was 12.51%, the glucose measured at 60 seconds was 97.38 mg, the dissolution rate was 31.30%, and the average release rate of glucose was delayed to 1.62 per second. The glucose measured by the three-layer protective film at 2 seconds, 30 seconds, and 60 seconds was 1.07, 27.62, and 70.71 mg, respectively, and the dissolution rates were 0.34%, 8.88%, and 22.73%, respectively. The average release rate is 1.18 mg per second.

由上述結果可知相較於未包覆之葡萄糖粉粒,具有澱粉薄膜之葡萄糖粉粒於各該時間點所測得之葡萄糖克數係顯著降低,如相較於未包覆澱粉薄膜之葡萄糖粉粒於60秒時所測得之葡萄糖溶出率59.37%,包覆有三層澱粉薄膜之葡萄糖粉粒於60秒時所得之溶出率則顯著降為22.73%,顯示澱粉薄膜確實能夠有效地阻隔及延緩葡萄糖於水溶液中釋出,而可達到味道修飾之目的。再者,透過增加澱粉薄膜數量,可加強延緩葡萄糖之溶出速率,如具有二層澱粉薄膜之葡萄糖粉粒於30秒所釋出之葡萄糖濃度較2秒時提高11.74%,而具有三層澱粉薄膜之葡萄糖粉粒於30秒所釋出之葡萄糖濃度較2秒時僅提高8.54%。From the above results, it can be seen that compared with the uncoated glucose powder particles, the glucose granules having the starch film have a significant decrease in the number of grams of glucose measured at each time point, such as glucose powder compared to the uncoated starch film. The glucose dissolution rate measured by the pellet at 60 seconds was 59.37%, and the dissolution rate of the glucose powder coated with the three-layer starch film at 60 seconds was significantly reduced to 22.73%, indicating that the starch film can effectively block and delay. Glucose is released in an aqueous solution for the purpose of taste modification. Furthermore, by increasing the amount of starch film, the dissolution rate of glucose can be enhanced. For example, the glucose powder having a two-layer starch film can increase the glucose concentration in 31 seconds by 11.74% compared with 2 seconds, and has a three-layer starch film. The glucose concentration released by the glucose powder in 30 seconds was only increased by 8.54% compared with 2 seconds.

實例四:製備經麥芽糊精修飾之黃連粉粒Example 4: Preparation of granules modified with maltodextrin

取將200公克、粒徑約55~500μm之黃連粉粒。將該黃連粉粒置於一水浴槽中,使該黃連粉粒表面佈滿水分子,並注入85℃之熱風, 再加入約10公克、粒徑1~10μm之麥芽糊精,進行不間斷地進行攪拌,使該麥芽糊精與該黃連粉粒快速地均勻混合,用以使該麥芽糊精藉由水分,附著於各該黃連粉粒上,並使麥芽糊精分子間相互連接而逐漸形成薄膜,並同步地進行乾燥以將薄膜固定於黃連粉粒表面上,避免再次於各該黃連粉粒表面形成過多水滴。重複上述加熱、調濕、乾燥等步驟一次,直至各該黃連粉粒完全地被由麥芽糊精所形成之二層薄膜所包覆住,再以85℃之熱風予以充分乾燥,而得到一經麥芽糊精修飾之黃連粉粒,如第九圖所示。Take 200 grams of berberine powder with a particle size of about 55~500μm. The coptis powder is placed in a water bath, the surface of the coptis powder is covered with water molecules, and a hot air of 85 ° C is injected. Further adding about 10 grams of maltodextrin having a particle diameter of 1 to 10 μm, and continuously stirring, so that the maltodextrin and the coptis powder are rapidly and uniformly mixed, so that the maltodextrin is used for Moisture, adhered to each of the coptis powder particles, and the maltodextrin molecules are connected to each other to gradually form a film, and simultaneously dried to fix the film on the surface of the berberine powder particles, avoiding again the coptis powder The surface forms too many water droplets. Repeat the above steps of heating, humidity control, drying, etc. until the coptis powder is completely covered by the two-layer film formed by maltodextrin, and then fully dried by hot air at 85 ° C to obtain a Maltodextrin-modified berberine powder, as shown in Figure IX.

以電子顯微鏡觀察不同粒徑之黃連粉粒經麥芽糊精修飾之過程,如第十圖A至G所示,其中,第十圖A至C係分別表現不同粒徑之黃連粉粒,第十圖D至F則係分別表現麥芽糊精已包覆於不同粒徑之黃連粉粒表面。由第十圖之結果顯示麥芽糊精確實地可於不同粒徑之黃連粉粒表面形成穩固之包覆層。The process of modifying the berberine powder of different particle sizes by maltodextrin was observed by electron microscopy, as shown in the tenth figure A to G, wherein the tenth figure A to C respectively showed the coptis powder of different particle diameters, Ten figures D to F show that maltodextrin has been coated on the surface of berberine powder with different particle sizes. From the results of the tenth graph, it is shown that the malt paste can form a stable coating layer on the surface of the coptis powder of different particle diameters accurately.

實例五:經麥芽糊精修飾之黃連粉粒之黃連素釋放試驗Example 5: Berberine release test of berberine powder modified by maltodextrin

藉由實例四之方法分別製備完成之具有一層麥芽糊精薄膜、二層麥芽糊精薄膜及三層麥芽糊精薄膜之黃連粉粒,並取未包覆麥芽糊精之黃連粉粒,如實例二中所述者,分別浸泡於蒸餾水中進行黃連素釋放試驗,結果如下表五與第十一圖所示。再者,計算出具有不同數量麥芽糊精薄膜之各該黃連粉粒以及未包覆麥芽糊精薄膜之黃連粉粒於水溶液中1分鐘內之黃連素平均釋放速率,結果如下表六所示。The coptis powder having a layer of maltodextrin film, a two-layer maltodextrin film and a three-layer maltodextrin film was prepared by the method of Example 4, and the coptis powder which was not coated with maltodextrin was taken. The granules, as described in Example 2, were each immersed in distilled water for the berberine release test, and the results are shown in Tables 5 and 11 below. Furthermore, the average release rate of berberine in each of the aqueous solution of the Coptidis powder having different amounts of maltodextrin film and the uncoated maltodextrin film in one minute was calculated, and the results are shown in Table 6 below. Show.

表五:黃連粉粒於不同時間點所溶出之黃連素含量(mg/100mL) Table 5: The content of berberine dissolved in berberine powder at different time points (mg/100mL)

由表五、表六及第十一圖之結果可知,未包覆之黃連粉粒於2秒時係測得47.73毫克之黃連素,溶出率為14.42%,於30秒時,黃連素濃度急速增高,所測得之黃連素係為261.15毫克,溶出率為78.88%,而於60秒時,已接近完全溶出,釋放出295.35毫克之黃連素,溶出率為89.21%,整體來說,黃連素之平均釋放速率為每秒4.92毫克;而包覆一層麥芽糊精薄膜之黃連粉粒於2秒、30秒及60秒所測得之黃連素克數分別為20.35、72.51和128.14毫克,黃連素之平均釋放速率為每秒2.14毫克;包覆二層麥芽糊精薄膜之黃連粉粒於2秒、30秒及60秒所測得之黃連素克數分別為13.64、44.16和74.68毫克,溶出率分別為4.12%、13.34%、22.56%,於一分鐘內黃連素之平均釋放速率為每秒1.24毫克;包覆三層麥芽糊精薄膜之黃連粉粒於2秒時所測得之黃連素濃度為6.93毫克,溶出率為2.09%,而後分別於30秒及60秒測得之黃連素克數為21.21及47.84毫克,溶出率分別 為6.41%及14.45%,於一分鐘內黃連素之平均釋放速率為每秒0.80毫克。From the results of Table 5, Table 6 and Figure 11, it can be seen that the uncoated berberine powder measured 47.73 mg of berberine at 2 seconds, and the dissolution rate was 14.42%. At 30 seconds, the concentration of berberine was rapid. Increased, the measured berberine was 261.15 mg, the dissolution rate was 78.88%, and at 60 seconds, it was nearly completely dissolved, releasing 295.35 mg of berberine, the dissolution rate was 89.21%. Overall, berberine The average release rate was 4.92 mg per second; and the berberine grams measured in 2, 30 and 60 seconds coated with a layer of maltodextrin film were 20.35, 72.51 and 128.14 mg, respectively. The average release rate was 2.14 mg per second; the berberine grams measured in 2, 30 and 60 seconds of the coptis powder coated with the two-layer maltodextrin film were 13.64, 44.16 and 74.68 mg, respectively. The dissolution rates were 4.12%, 13.34%, and 22.56%, respectively. The average release rate of berberine was 1.24 mg per second in one minute. The coptis powder coated with the three-layer maltodextrin film was measured at 2 seconds. The concentration of berberine was 6.93 mg, the dissolution rate was 2.09%, and then measured at 30 seconds and 60 seconds, respectively. The berberine grams are 21.21 and 47.84 mg, respectively. At 6.41% and 14.45%, the average release rate of berberine was 0.80 mg per second in one minute.

由上述結果可知相較於未包覆之黃連粉粒,具有麥芽糊精薄膜之黃連粉粒於各該時間點所測得之黃連素克數係顯著降低,顯示麥芽糊精薄膜確實能夠有效地阻隔及延緩黃連素於水溶液中釋出,達到味道修飾之目的。再者,透過增加麥芽糊精薄膜數量,可加強延緩黃連素之溶出速率,如具有二層麥芽糊精薄膜之黃連粉粒於30秒所釋出之黃連素濃度較2秒時提高9.22%,而具有三層麥芽糊精薄膜之黃連粉粒於30秒所釋出之黃連素濃度較2秒時僅提高4.32%。From the above results, it can be seen that compared with the uncoated berberine powder, the berberine gram count of the berberine powder having the maltodextrin film at each time point is significantly reduced, indicating that the maltodextrin film can indeed Effectively block and delay the release of berberine in aqueous solution for the purpose of taste modification. Furthermore, by increasing the amount of maltodextrin film, the dissolution rate of berberine can be enhanced. For example, the berberine concentration released by the copper powder having the two-layer maltodextrin film is increased by 9.22 in 2 seconds. %, and the berberine concentration released by the three-layer maltodextrin film in 30 seconds was only 4.32% higher than that at 2 seconds.

實例六:經糖粉修飾之黃連粉粒Example 6: Coptis powder modified by powdered sugar

如實例一所述方法,進行製備以糖粉所形成之薄膜所包覆之黃連粉粒,而其製備過程以電子顯微鏡觀察,如第十二圖A及B所示,其中,第十二圖A係為包覆前,第十二圖B係為完成包覆。由第十二圖之結果顯示糖粉係可於黃連粉粒表面形成穩固之包覆層,而達到修飾黃連粉粒之功效。According to the method of Example 1, the preparation of the Coptidis powder coated with the film formed by the powdered sugar is carried out, and the preparation process thereof is observed by an electron microscope, as shown in FIG. 12A and B, wherein the twelfth image The A system is before coating, and the twelfth image B is for completion coating. From the results of the twelfth figure, it is shown that the sugar powder system can form a stable coating layer on the surface of the berberine powder to achieve the effect of modifying the coptis powder.

據此,藉由本發明所揭修飾粉末外觀及/或味道之方法,乃係可將粉末狀物質確實地以天然包覆物於其表面形成一保護層,由於不須使用任何化學添加物,因而可確保食品對於人體之安全性,並有效遮掩粉末狀物質之不良色、味、外觀,達到修飾粉末狀物質之功效,且能夠提昇粉末狀物質之保存性。Accordingly, the method for modifying the appearance and/or taste of a powder by the present invention is such that the powdery substance can form a protective layer on the surface of the natural coating, since no chemical additives are required. It can ensure the safety of the food to the human body, and effectively mask the bad color, taste and appearance of the powdery substance, achieve the effect of modifying the powdery substance, and can improve the preservation of the powdery substance.

以上僅是藉由較佳實例詳細說明本發明,對於各該實施例所做的任何簡單修改或是變化,均應為本案申請專利範圍所得涵攝者。The above is only a detailed description of the present invention by way of a preferred example, and any simple modifications or variations made to the embodiments are intended to be the subject of the patent application.

(10)‧‧‧修飾粉末外觀及/或味道之方法(10) ‧‧‧Methods for modifying the appearance and/or taste of powders

(20)‧‧‧黃連粉粒(20) ‧‧‧Coptis powder

(30)‧‧‧水分子(30) ‧ ‧ water molecules

(40)‧‧‧澱粉(40)‧‧‧ Starch

(50)‧‧‧薄膜(50) ‧‧‧film

(60)‧‧‧經修飾之黃連粉粒(60)‧‧‧Modified berberine powder

Claims (16)

一種修飾粉末外觀及/或味道之方法,係包含有以下步驟:步驟a:取一粉粒;步驟b:取一包覆物,與該粉粒均勻混合,而附著於該粉粒表面,其中,該包覆物係為醣類;步驟c:該包覆物於一預定溫度及濕度之環境下藉由水合反應而逐漸於該粉粒表面形成一薄膜;步驟d:進行乾燥,使該薄膜固定於該粉粒表面;步驟e:獲得一經修飾之粉末。A method for modifying the appearance and/or taste of a powder comprises the steps of: step a: taking a powder; step b: taking a coating, uniformly mixing with the powder, and attaching to the surface of the powder, wherein The coating is a saccharide; step c: the coating gradually forms a film on the surface of the granule by a hydration reaction under a predetermined temperature and humidity; step d: drying, the film is made Fixed to the surface of the powder; step e: obtaining a modified powder. 依據申請專利範圍第1項所述飾粉末外觀及/或味道之方法,其中,該步驟a之該粉粒表面係具有水分子。A method of decorating the appearance and/or taste of a powder according to the first aspect of the invention, wherein the surface of the powder of the step a has water molecules. 依據申請專利範圍第2項所述修飾粉末外觀及/或味道之方法,其中,該步驟a之該粉粒係置於一水浴槽中。A method of modifying the appearance and/or taste of a powder according to the scope of claim 2, wherein the powder of the step a is placed in a water bath. 依據申請專利範圍第1項所述修飾粉末外觀及/或味道之方法,其中,該步驟b之該包覆物係選自由澱粉、澱粉衍生物及含有上述成份之組合物所組成之群。A method of modifying the appearance and/or taste of a powder according to the first aspect of the invention, wherein the coating of the step b is selected from the group consisting of starch, a starch derivative and a composition comprising the above ingredients. 依據申請專利範圍第4項所述修飾粉末外觀及/或味道之方法,其中,該包覆物係為麥芽糊精。A method of modifying the appearance and/or taste of a powder according to claim 4, wherein the coating is maltodextrin. 依據申請專利範圍第4項所述修飾粉末外觀及/或味道之方法,其中,該包覆物係為由麥芽糊精及食用膠依一預定比例所混合而成之組合物。A method for modifying the appearance and/or taste of a powder according to the fourth aspect of the invention, wherein the coating is a composition obtained by mixing maltodextrin and edible gum in a predetermined ratio. 依據申請專利範圍第6項所述修飾粉末外觀及/或味道之方法,其 中,該食用膠於該組合物中之比例係不超過35%。 A method of modifying the appearance and/or taste of a powder as described in claim 6 of the scope of the patent application, The proportion of the edible gum in the composition is not more than 35%. 依據申請專利範圍第1項所述修飾粉末外觀及/或味道之方法,其中,該包覆物係為糖粉。 A method of modifying the appearance and/or taste of a powder according to the first aspect of the invention, wherein the coating is a powdered sugar. 依據申請專利範圍第1、2、3、4、6、7或8項所述修飾粉末外觀及/或味道之方法,其中,該粉粒之粒徑係為30~800μm。 A method of modifying the appearance and/or taste of a powder according to the first, second, third, fourth, sixth, seventh or eighth aspect of the patent application, wherein the particle size of the powder is from 30 to 800 μm. 依據申請專利範圍第1、2、3、4、6、7或8項所述修飾粉末外觀及/或味道之方法,其中,該包覆物之粒徑係為1~80μm。 A method of modifying the appearance and/or taste of a powder according to the first, second, third, fourth, sixth, seventh or eighth aspect of the patent application, wherein the particle size of the coating is from 1 to 80 μm. 依據申請專利範圍第10項所述修飾粉末外觀及/或味道之方法,其中,該包覆物之粒徑係為1~15μm。 A method for modifying the appearance and/or taste of a powder according to claim 10, wherein the coating has a particle diameter of from 1 to 15 μm. 依據申請專利範圍第1、2、3、4、6、7或8項所述修飾粉末外觀及/或味道之方法,其中,步驟c中之該預定溫度係為45~150℃。 A method of modifying the appearance and/or taste of a powder as described in claim 1, 2, 3, 4, 6, 7, or 8, wherein the predetermined temperature in step c is 45 to 150 °C. 依據申請專利範圍第12項所述修飾粉末外觀及/或味道之方法,其中,步驟c之該預定溫度係為60~100℃。 The method for modifying the appearance and/or taste of a powder according to claim 12, wherein the predetermined temperature of the step c is 60 to 100 °C. 依據申請專利範圍第1、2、3、4、6、7或8項所述修飾粉末外觀及/或味道之方法,其中,步驟c中之該預定濕度係為90~100%The method of modifying the appearance and/or taste of a powder according to the first, second, third, fourth, sixth, seventh or eighth aspect of the patent application, wherein the predetermined humidity in the step c is 90 to 100% . 依據申請專利範圍第1、2、3、4、6、7或8項所述修飾粉末外觀及/或味道之方法,其更包含一介於該步驟d及該步驟e間之步驟d1,係將步驟d所得之物重複進行步驟b至步驟d至少一次。 The method for modifying the appearance and/or taste of a powder according to the first, second, third, fourth, sixth, seventh or eighth aspect of the patent application, further comprising a step d1 between the step d and the step e, Step b to step d are repeated at least once in the step d. 依據申請專利範圍第15項所述修飾粉末外觀及/或味道之方法,其中,於重複步驟b時,所使用之該包覆物係得不同於第一次所使用之該包覆物。A method of modifying the appearance and/or taste of a powder according to claim 15 wherein, in the repetition of step b, the coating used is different from the coating used in the first time.
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2146867A (en) * 1937-06-07 1939-02-14 Welin Sater Company Medicinal preparation and method of making the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2146867A (en) * 1937-06-07 1939-02-14 Welin Sater Company Medicinal preparation and method of making the same

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