TWI326598B - Unit dosage forms of temozolomide - Google Patents

Unit dosage forms of temozolomide Download PDF

Info

Publication number: TWI326598B
Authority: TW; Taiwan
Prior art keywords: days; per day; day; patient; day cycle
Prior art date: 2006-06-26

Application number

TW096122905A

Other languages

English (en)

Chinese (zh)

Other versions

TW200808803A (en

Inventor

Jacqueline Rose Bersch

Mark Manzo

Sumant Ramachandra

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-26

Filing date

2007-06-25

Publication date

2010-07-01

2007-06-25 Application filed by Schering Corp filed Critical Schering Corp

2008-02-16 Publication of TW200808803A publication Critical patent/TW200808803A/zh

2010-07-01 Application granted granted Critical

2010-07-01 Publication of TWI326598B publication Critical patent/TWI326598B/zh

Links

239000002552 dosage form Substances 0.000 title claims description 100
BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 title description 5
229960004964 temozolomide Drugs 0.000 title description 3
102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims description 91
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239000003814 drug Substances 0.000 claims description 57
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239000002775 capsule Substances 0.000 claims description 36
238000000034 method Methods 0.000 claims description 32
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IDPUKCWIGUEADI-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]uracil Chemical compound ClCCN(CCCl)C1=CNC(=O)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 description 2
SVASVGVAQIVSEZ-UHFFFAOYSA-N 5-amino-2H-isoquinolin-1-one Chemical compound C1=CNC(=O)C2=C1C(N)=CC=C2 SVASVGVAQIVSEZ-UHFFFAOYSA-N 0.000 description 2
NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 2
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TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

TW096122905A 2006-06-26 2007-06-25 Unit dosage forms of temozolomide TWI326598B (en)

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US81662306P	2006-06-26	2006-06-26

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TWI326598B true TWI326598B (en)	2010-07-01

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EP (1)	EP1901740A2 (fr)
JP (1)	JP2008534692A (fr)
KR (2)	KR20080015777A (fr)
CN (1)	CN101309686A (fr)
AR (1)	AR061618A1 (fr)
AU (1)	AU2007221979A1 (fr)
BR (1)	BRPI0702847A (fr)
CA (1)	CA2610439A1 (fr)
CL (1)	CL2007001864A1 (fr)
NO (1)	NO20074913L (fr)
TW (1)	TWI326598B (fr)
WO (1)	WO2008002544A2 (fr)
ZA (1)	ZA200708280B (fr)

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* Cited by examiner, † Cited by third party
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CN102526038B (zh) *	2011-01-12	2013-09-11	北京人福军威医药技术开发有限公司	替莫唑胺的脑靶向药物组合物及其应用
WO2017165266A1 (fr) *	2016-03-21	2017-09-28	Duke University	Traitement anticancéreux séquentiel
WO2018167627A1 (fr)	2017-03-13	2018-09-20	Ftf Pharma Private Limited	Composition pharmaceutique de suspension orale d'agents d'alkylation anti-néoplasiques

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Publication number	Priority date	Publication date	Assignee	Title
DE60024243T2 (de) *	1999-03-30	2006-08-17	Schering Corp.	Verbesserte krebsbehandlung mit temozolomid
JP2008519584A (ja) *	2004-11-09	2008-06-12	シェーリングコーポレイション	患者のｍｇｍｔレベルに基づいて癌を処置するための、テモゾロミドの改良された投薬養生法

2007
- 2007-06-22 AR ARP070102775A patent/AR061618A1/es unknown
- 2007-06-25 CN CNA2007800001411A patent/CN101309686A/zh active Pending
- 2007-06-25 BR BRPI0702847-4A patent/BRPI0702847A/pt not_active IP Right Cessation
- 2007-06-25 CL CL200701864A patent/CL2007001864A1/es unknown
- 2007-06-25 KR KR1020077022177A patent/KR20080015777A/ko not_active Ceased
- 2007-06-25 EP EP07796436A patent/EP1901740A2/fr not_active Withdrawn
- 2007-06-25 TW TW096122905A patent/TWI326598B/zh active
- 2007-06-25 WO PCT/US2007/014761 patent/WO2008002544A2/fr not_active Ceased
- 2007-06-25 KR KR1020107009528A patent/KR20100055543A/ko not_active Withdrawn
- 2007-06-25 CA CA002610439A patent/CA2610439A1/fr not_active Abandoned
- 2007-06-25 JP JP2008523051A patent/JP2008534692A/ja not_active Withdrawn
- 2007-06-25 AU AU2007221979A patent/AU2007221979A1/en not_active Abandoned
- 2007-09-27 ZA ZA200708280A patent/ZA200708280B/xx unknown
- 2007-09-27 NO NO20074913A patent/NO20074913L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW200808803A (en)	2008-02-16
ZA200708280B (en)	2009-03-25
CN101309686A (zh)	2008-11-19
AR061618A1 (es)	2008-09-10
JP2008534692A (ja)	2008-08-28
KR20100055543A (ko)	2010-05-26
WO2008002544A3 (fr)	2008-02-07
WO2008002544A2 (fr)	2008-01-03
BRPI0702847A (pt)	2008-04-01
CA2610439A1 (fr)	2007-12-26
NO20074913L (no)	2009-03-26
CL2007001864A1 (es)	2008-02-08
AU2007221979A1 (en)	2008-01-10
KR20080015777A (ko)	2008-02-20
EP1901740A2 (fr)	2008-03-26
AU2007221979A9 (en)	2008-01-10

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