TWI318981B - Novel thiophene glycoside derivatives, processes for their preparation , medicaments comprising these compounds, and the use thereof - Google Patents

Novel thiophene glycoside derivatives, processes for their preparation , medicaments comprising these compounds, and the use thereof

Info

Publication number: TWI318981B
Authority: TW; Taiwan
Prior art keywords: medicaments; compounds; processes; preparation; glycoside derivatives
Prior art date: 2002-07-11

Application number

TW092118657A

Other languages

English (en)

Other versions

TW200410979A (en

Inventor

Glombik Heiner

Frick Wendelin

Heuer Hubert

Kramer Werner

Brummerhop Harm

Plettenburg Oliver

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-11

Filing date

2003-07-09

Publication date

2010-01-01

2003-07-09 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2004-07-01 Publication of TW200410979A publication Critical patent/TW200410979A/zh

2010-01-01 Application granted granted Critical

2010-01-01 Publication of TWI318981B publication Critical patent/TWI318981B/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Hematology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Psychiatry (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)

TW092118657A 2002-07-11 2003-07-09 Novel thiophene glycoside derivatives, processes for their preparation , medicaments comprising these compounds, and the use thereof TWI318981B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10231370A DE10231370B4 (de)	2002-07-11	2002-07-11	Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel

Publications (2)

Publication Number	Publication Date
TW200410979A TW200410979A (en)	2004-07-01
TWI318981B true TWI318981B (en)	2010-01-01

Family

ID=30009905

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW092118657A TWI318981B (en)	2002-07-11	2003-07-09	Novel thiophene glycoside derivatives, processes for their preparation , medicaments comprising these compounds, and the use thereof

Country Status (39)

Country	Link
US (2)	US7101856B2 (zh)
EP (4)	EP1964844B1 (zh)
JP (1)	JP4511927B2 (zh)
KR (1)	KR20050021452A (zh)
CN (2)	CN101240000A (zh)
AR (1)	AR040474A1 (zh)
AT (4)	ATE477265T1 (zh)
AU (1)	AU2003246620B2 (zh)
BR (1)	BR0312513A (zh)
CA (1)	CA2493391C (zh)
CR (1)	CR7718A (zh)
CY (1)	CY1108754T1 (zh)
DE (5)	DE10231370B4 (zh)
DK (1)	DK1523488T3 (zh)
EC (1)	ECSP055531A (zh)
ES (1)	ES2316818T3 (zh)
HN (1)	HN2003000215A (zh)
HR (1)	HRP20050014A2 (zh)
IL (2)	IL166058A0 (zh)
JO (1)	JO2707B1 (zh)
MA (1)	MA27366A1 (zh)
ME (1)	MEP60708A (zh)
MX (1)	MXPA05000044A (zh)
MY (1)	MY137039A (zh)
NO (1)	NO20050649L (zh)
OA (1)	OA12880A (zh)
PA (1)	PA8577101A1 (zh)
PE (1)	PE20040655A1 (zh)
PL (1)	PL372931A1 (zh)
PT (1)	PT1523488E (zh)
RS (1)	RS51002B (zh)
RU (1)	RU2317300C2 (zh)
SI (1)	SI1523488T1 (zh)
TN (1)	TNSN05007A1 (zh)
TW (1)	TWI318981B (zh)
UA (1)	UA78823C2 (zh)
UY (1)	UY27891A1 (zh)
WO (1)	WO2004007517A1 (zh)
ZA (1)	ZA200409779B (zh)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1020944C (zh)	1990-01-30	1993-05-26	阿图尔-费希尔股份公司费希尔厂	紧固件
DE10258008B4 (de) *	2002-12-12	2006-02-02	Sanofi-Aventis Deutschland Gmbh	Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10308353A1 (de)	2003-02-27	2004-12-02	Aventis Pharma Deutschland Gmbh	Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7439232B2 (en)	2003-04-01	2008-10-21	Taisho Pharmaceutical Co., Ltd.	Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
ES2649737T5 (es)	2003-08-01	2021-07-07	Mitsubishi Tanabe Pharma Corp	Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio
US8785403B2 (en)	2003-08-01	2014-07-22	Mitsubishi Tanabe Pharma Corporation	Glucopyranoside compound
TW200606129A (en)	2004-07-26	2006-02-16	Chugai Pharmaceutical Co Ltd	Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
WO2006010379A1 (en)	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
DE102004063099B4 (de) *	2004-12-22	2009-02-12	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Thiophenglycosidderivaten
TW200637869A (en)	2005-01-28	2006-11-01	Chugai Pharmaceutical Co Ltd	The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
MY147375A (en)	2005-01-31	2012-11-30	Mitsubishi Tanabe Pharma Corp	Indole derivatives
AR053329A1 (es) *	2005-01-31	2007-05-02	Tanabe Seiyaku Co	Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
ES2370791T3 (es)	2005-03-23	2011-12-22	Actelion Pharmaceuticals Ltd.	Nuevos derivados de tiofeno como agonistas del receptor de esfingosina-1-fosfato-1.
US7772191B2 (en)	2005-05-10	2010-08-10	Boehringer Ingelheim International Gmbh	Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
DE102005026762A1 (de)	2005-06-09	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
CN101203503B (zh)	2005-06-24	2011-12-28	埃科特莱茵药品有限公司	新颖噻吩衍生物
BRPI0706725A2 (pt)	2006-01-24	2011-04-05	Actelion Pharmaceuticals Ltda	Composto de sais do mesmo , composição farmacêutica , e , uso de um composto
PE20080697A1 (es)	2006-05-03	2008-08-05	Boehringer Ingelheim Int	Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
TWI432446B (zh)	2006-07-27	2014-04-01	Chugai Pharmaceutical Co Ltd	稠環螺酮縮醇衍生物、及其做為糖尿病治療藥之使用
TWI403516B (zh)	2006-07-27	2013-08-01	Chugai Pharmaceutical Co Ltd	To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes
TWI418556B (zh)	2006-07-27	2013-12-11	Mitsubishi Tanabe Pharma Corp	吲哚衍生物
CA2666193A1 (en)	2006-08-08	2008-02-14	Sanofi-Aventis	Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
CN101522699A (zh)	2006-10-13	2009-09-02	中外制药株式会社	硫葡萄糖螺缩酮衍生物、及其作为糖尿病治疗药的应用
US7666845B2 (en)	2006-12-04	2010-02-23	Janssen Pharmaceutica N.V.	Compounds having inhibitory activity against sodium-dependent glucose transporter
UY30730A1 (es)	2006-12-04	2008-07-03	Mitsubishi Tanabe Pharma Corp	Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE20090938A1 (es)	2007-08-16	2009-08-08	Boehringer Ingelheim Int	Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo
PL2200606T3 (pl)	2007-09-10	2018-08-31	Janssen Pharmaceutica, N.V.	Sposób wytwarzania związków użytecznych jako inhibitory SGLT2
CL2008003653A1 (es)	2008-01-17	2010-03-05	Mitsubishi Tanabe Pharma Corp	Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
WO2009138195A2 (en) *	2008-05-16	2009-11-19	Sanofi-Aventis Deutschland Gmbh	Use of thiophene glycoside derivatives for producing medicaments for treatment of hypertension
AR072707A1 (es)	2008-07-09	2010-09-15	Sanofi Aventis	Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
AU2009286380B2 (en) *	2008-08-28	2011-09-15	Pfizer Inc.	Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
US9056850B2 (en)	2008-10-17	2015-06-16	Janssen Pharmaceutica N.V.	Process for the preparation of compounds useful as inhibitors of SGLT
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US20110046076A1 (en)	2009-02-13	2011-02-24	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US20110009347A1 (en)	2009-07-08	2011-01-13	Yin Liang	Combination therapy for the treatment of diabetes
WO2011003976A1 (en)	2009-07-10	2011-01-13	Janssen Pharmaceutica Nv	CRYSTALLISATION PROCESS FOR 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL] BENZENE
AU2010288523A1 (en)	2009-08-26	2012-03-15	Sanofi	Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
CA2775961C (en)	2009-09-30	2017-11-07	Boehringer Ingelheim International Gmbh	Method for the preparation of a crystalline form of 1-chloro-4-(beta-d-glucopyranos-1-yl)-2-(4-((s)-tetrahydrofuran-3-yloxy)benzyl)benzene
DK2486029T3 (en)	2009-09-30	2015-08-24	Boehringer Ingelheim Int	Methods of making of glucopyranosyl-substituted benzyl-benzene derivatives.
UY32919A (es)	2009-10-02	2011-04-29	Boehringer Ingelheim Int	Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
RS55909B1 (sr)	2009-10-14	2017-09-29	Janssen Pharmaceutica Nv	Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
AU2010309788A1 (en)	2009-10-20	2012-04-05	Novartis Ag	Glycoside derivative and uses thereof
US8163704B2 (en)	2009-10-20	2012-04-24	Novartis Ag	Glycoside derivatives and uses thereof
NZ599945A (en)	2009-11-02	2014-05-30	Pfizer	Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2552442A1 (en)	2010-03-30	2013-02-06	Boehringer Ingelheim International GmbH	Pharmaceutical composition comprising an sglt2 inhibitor and a ppar- gamma agonist and uses thereof
US20130023494A1 (en)	2010-04-06	2013-01-24	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
BR112012028857B1 (pt)	2010-05-11	2021-02-09	Janssen Pharmaceutica Nv	Composições farmacêuticas administráveis por via oral que compreendem derivados de 1- (beta-d glucopiranosil)-2-tienil-metilbenzeno como inibidores de sglt
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
BR112013008100A2 (pt)	2010-09-22	2016-08-09	Arena Pharm Inc	"moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
US20120283169A1 (en)	2010-11-08	2012-11-08	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
JP2014505058A (ja) *	2011-01-11	2014-02-27	ザ・ユニバーシティ・オブ・テキサス・エム・ディー・アンダーソン・キャンサー	増殖性および炎症性皮膚疾患の治療用単糖ベース化合物
US20130035281A1 (en)	2011-02-09	2013-02-07	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
UY33937A (es)	2011-03-07	2012-09-28	Boehringer Ingelheim Int	Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina
EP2683701B1 (de)	2011-03-08	2014-12-24	Sanofi	Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683700B1 (de)	2011-03-08	2015-02-18	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683702B1 (de)	2011-03-08	2014-12-24	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828995B2 (en)	2011-03-08	2014-09-09	Sanofi	Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8809325B2 (en)	2011-03-08	2014-08-19	Sanofi	Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
WO2012120057A1 (de)	2011-03-08	2012-09-13	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US20140018371A1 (en)	2011-04-01	2014-01-16	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
AU2012241897C1 (en)	2011-04-13	2017-05-11	Janssen Pharmaceutica Nv	Process for the preparation of compounds useful as inhibitors of SGLT2
WO2012140596A1 (en)	2011-04-14	2012-10-18	Novartis Ag	Glycoside derivatives and uses thereof
US8614195B2 (en)	2011-04-14	2013-12-24	Novartis Ag	Glycoside derivatives and uses thereof
WO2012145361A1 (en)	2011-04-19	2012-10-26	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140038889A1 (en)	2011-04-22	2014-02-06	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140051714A1 (en)	2011-04-22	2014-02-20	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
TWI542596B (zh)	2011-05-09	2016-07-21	健生藥品公司	（２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
EA201301354A1 (ru)	2011-06-03	2014-05-30	Бёрингер Ингельхайм Интернациональ Гмбх	Ингибиторы sglt-2, предназначенные для лечения метаболических нарушений у пациентов, леченных нейролептиками
WO2012170702A1 (en)	2011-06-08	2012-12-13	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013055910A1 (en)	2011-10-12	2013-04-18	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US9192617B2 (en)	2012-03-20	2015-11-24	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
WO2014074668A1 (en)	2012-11-08	2014-05-15	Arena Pharmaceuticals, Inc.	Modulators of gpr119 and the treatment of disorders related thereto
EP2774619B1 (de)	2013-03-04	2016-05-18	BioActive Food GmbH	Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
WO2014159151A1 (en)	2013-03-14	2014-10-02	Msd International Gmbh	Methods for preparing sglt2 inhibitors
PL2981269T3 (pl)	2013-04-04	2024-02-05	Boehringer Ingelheim Vetmedica Gmbh	Leczenie zaburzeń metabolicznych u zwierząt koniowatych
TR201901110T4 (tr)	2013-04-05	2019-02-21	Boehringer Ingelheim Int	Empagliflozinin terapötik kullanımları.
US11813275B2 (en)	2013-04-05	2023-11-14	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
HK1213818A1 (zh)	2013-04-05	2016-07-15	勃林格殷格翰国际有限公司	依帕列净的治疗用途
WO2014165736A2 (en)	2013-04-05	2014-10-09	Board Of Regents, The University Of Texas System	Esters of 2-deoxy-monosaccharides with anti proliferative activity
CA2812519A1 (en)	2013-04-05	2014-10-05	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
DK2986304T3 (da)	2013-04-18	2022-04-04	Boehringer Ingelheim Int	Farmaceutisk sammensætning, fremgangsmåder til behandling og anvendelser deraf.
ES2859905T3 (es)	2013-12-17	2021-10-04	Boehringer Ingelheim Vetmedica Gmbh	Inhibidores de SGLT2 para el tratamiento de trastornos metabólicos en animales felinos
US10603300B2 (en)	2014-01-23	2020-03-31	Boehringer Ingelheim Vetmedica Gmbh	Treatment of metabolic disorders in canine animals
ES2811261T3 (es)	2014-04-01	2021-03-11	Boehringer Ingelheim Vetmedica Gmbh	Tratamiento de trastornos metabólicos en animales equinos
EP2944311A1 (de)	2014-05-16	2015-11-18	BioActive Food GmbH	Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
ES2991763T3 (es)	2014-09-25	2024-12-04	Boehringer Ingelheim Vetmedica Gmbh	Tratamiento de combinación de inhibidores de SGLT2 y agonistas de dopamina para la prevención de trastornos metabólicos en animales equinos
CN104478968A (zh) *	2015-01-14	2015-04-01	佛山市赛维斯医药科技有限公司	含噻唑基的o-半乳糖苷衍生物、其制备方法和用途
CN104478966A (zh) *	2015-01-14	2015-04-01	佛山市赛维斯医药科技有限公司	含苯胺噻唑基的o-半乳糖苷衍生物、其制备方法和用途
US20170071970A1 (en)	2015-09-15	2017-03-16	Janssen Pharmaceutica Nv	Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
MX2019004549A (es)	2016-10-19	2019-06-12	Boehringer Ingelheim Int	Combinaciones que comprenden un inhibidor ssao/vap-1 y un inhibidor sglt2 y usos de los mismos.
AU2017357589B2 (en)	2016-11-10	2023-05-11	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
WO2019201752A1 (en)	2018-04-17	2019-10-24	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
WO2020039394A1 (en)	2018-08-24	2020-02-27	Novartis Ag	New drug combinations
BR112021004635A2 (pt)	2018-10-29	2021-05-25	Boehringer Ingelheim International Gmbh	derivados de piridinil sulfonamida, composições farmacêuticas e usos das mesmas
CN112955214B (zh)	2018-10-29	2024-05-07	勃林格殷格翰国际有限公司	吡啶基磺酰胺衍生物、药物组合物及其用途
UY38969A (es)	2019-11-28	2021-05-31	Boehringer Ingelheim Vetmedica Gmbh	Uso de inhibidores de sglt-2 en el secado de mamíferos no humanos
CN118615450A (zh)	2020-02-17	2024-09-10	勃林格殷格翰动物保健有限公司	Sglt-2抑制剂用于预防和/或治疗猫科动物的心脏疾病的用途
EP4376819A1 (en)	2021-07-28	2024-06-05	Boehringer Ingelheim Vetmedica GmbH	Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
JP2024525981A (ja)	2021-07-28	2024-07-12	ベーリンガーインゲルハイムフェトメディカゲーエムベーハー	ヒト以外の哺乳動物における腎疾患の予防及び／又は治療のためのｓｇｌｔ－２阻害剤の使用
CA3223537A1 (en)	2021-07-28	2023-02-02	Boehringer Ingelheim Vetmedica Gmbh	Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in non-human mammals excluding felines, in particular canines
CA3242880A1 (en)	2021-12-30	2023-07-06	Newamsterdam Pharma B.V.	COMBINATION OF OBITECRAPIB AND SGLT2 INHIBITOR
JP2025516857A (ja)	2022-05-25	2025-05-30	ベーリンガーインゲルハイムフェトメディカゲーエムベーハー	Ｓｇｌｔ－２阻害薬を含む水性医薬組成物
KR20240109921A (ko)	2023-01-05	2024-07-12	아주대학교산학협력단	Gptc 제조방법
AU2024233233A1 (en)	2023-03-06	2025-09-11	Boehringer Ingelheim Vetmedica Gmbh	Systems for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s)
KR20250172894A (ko)	2023-04-24	2025-12-09	뉴암스테르담 파마 비.브이.	비정질 오비세트라피브 및 sglt2 억제제 조합
WO2024240633A1 (en)	2023-05-24	2024-11-28	Boehringer Ingelheim Vetmedica Gmbh	Combination treatment and/or prevention of renal diseases and/or hypertension in non-human mammals comprising one or more sglt-2 inhibitors and telmisartan
TW202508593A (zh)	2023-05-24	2025-03-01	德商百靈佳殷格翰維美迪加股份有限公司	包含一或多種sglt-2抑制劑及匹莫苯坦(pimobendan)及/或替米沙坦(telmisartan)之非人類哺乳動物心臟病之組合治療及/或預防

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA165448A (en)	1914-10-23	1915-10-12	Otto F. Hornschuch	Ironing board
FR2663336B1 (fr)	1990-06-18	1992-09-04	Adir	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
BR9707003A (pt)	1996-01-17	1999-07-20	Novo Nordisk As	Composto processos para preparar o mesmo para tratamento ou de prevenção de doenças do sistema endócrino e para a manufatura de medicamento coposção farmacêutica e utilização de um composto
IL128332A0 (en)	1996-08-30	2000-01-31	Novo Nordisk As	GLP-1 derivatives
DE69723869T2 (de)	1996-12-31	2004-04-22	Dr. Reddy's Laboratories Ltd.	Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
DE19726167B4 (de)	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
IL133604A0 (en)	1997-07-16	2001-04-30	Novo Nordisk As	Fused 1, 2, 4-thiadiazine derivatives, their preparation and use
CO4970713A1 (es)	1997-09-19	2000-11-07	Sanofi Synthelabo	Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
GB9900416D0 (en)	1999-01-08	1999-02-24	Alizyme Therapeutics Ltd	Inhibitors
CN1183113C (zh)	1999-04-28	2005-01-05	阿文蒂斯药物德国有限公司	作为ppar受体配体的三芳基酸衍生物
HRP20010795A2 (en)	1999-04-28	2003-02-28	Aventis Pharma Gmbh	Di-aryl acid derivatives as ppar receptor ligands
AU4808300A (en)	1999-04-30	2000-11-17	Neurogen Corporation	9h-pyrimido(4,5-b)indole derivatives: crf1 specific ligands
GB9911863D0 (en)	1999-05-21	1999-07-21	Knoll Ag	Therapeutic agents
JP2003502369A (ja)	1999-06-18	2003-01-21	メルクエンドカムパニーインコーポレーテッド	アリールチアゾリジンジオン誘導体およびアリールオキサゾリジンジオン誘導体
ES2203498T3 (es)	1999-07-29	2004-04-16	Eli Lilly And Company	Benzofurilpiperazinas: agonistas de receptor 5-ht2c de la serotonina.
US6324512B1 (en)	1999-08-26	2001-11-27	Matsushita Electric Industrial Co., Ltd.	System and method for allowing family members to access TV contents and program media recorder over telephone or internet
NZ517439A (en) *	1999-08-31	2003-03-28	Kissei Pharmaceutical	Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof
ES2287120T3 (es)	2000-04-28	2007-12-16	Asahi Kasei Pharma Corporation	Nuevos compuestos biciclicos.
ATE310728T1 (de)	2000-05-11	2005-12-15	Bristol Myers Squibb Co	Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga
EP1289526A4 (en)	2000-05-30	2005-03-16	Merck & Co Inc	MELANOCORTIN RECEPTOR AGONISTS

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Publication number	Publication date
EP1964845B1 (de)	2010-08-11
DK1523488T3 (da)	2009-03-16
MEP60708A (en)	2011-05-10
HN2003000215A (es)	2004-07-27
MA27366A1 (fr)	2005-06-01
PA8577101A1 (es)	2004-02-07
JO2707B1 (ar)	2014-03-15
AR040474A1 (es)	2005-04-06
RS51002B (sr)	2010-10-31
JP2005536497A (ja)	2005-12-02
CR7718A (es)	2006-05-11
EP1967523B1 (de)	2010-08-11
CA2493391A1 (en)	2004-01-22
ATE477265T1 (de)	2010-08-15
UY27891A1 (es)	2003-12-31
US20060293252A1 (en)	2006-12-28
DE10231370A1 (de)	2004-02-05
CN101240000A (zh)	2008-08-13
ATE477266T1 (de)	2010-08-15
RU2005103602A (ru)	2005-07-20
EP1523488A1 (de)	2005-04-20
TNSN05007A1 (en)	2007-05-14
TW200410979A (en)	2004-07-01
WO2004007517A1 (de)	2004-01-22
EP1967523A1 (de)	2008-09-10
PT1523488E (pt)	2009-01-30
ATE479697T1 (de)	2010-09-15
ECSP055531A (es)	2005-03-10
ES2316818T3 (es)	2009-04-16
US7666848B2 (en)	2010-02-23
DE50312983D1 (de)	2010-09-23
ATE414095T1 (de)	2008-11-15
MY137039A (en)	2008-12-31
MXPA05000044A (es)	2005-04-08
DE10231370B4 (de)	2006-04-06
OA12880A (en)	2006-09-15
DE50312984D1 (de)	2010-09-23
CY1108754T1 (el)	2014-04-09
EP1964845A1 (de)	2008-09-03
CN1668628A (zh)	2005-09-14
EP1964844A1 (de)	2008-09-03
AU2003246620A1 (en)	2004-02-02
CN100384863C (zh)	2008-04-30
BR0312513A (pt)	2005-04-12
HRP20050014A2 (hr)	2006-04-30
PL372931A1 (en)	2005-08-08
RS115004A (sr)	2007-02-05
HK1080482A1 (zh)	2006-04-28
UA78823C2 (en)	2007-04-25
DE50313056D1 (de)	2010-10-14
US7101856B2 (en)	2006-09-05
IL191926A0 (en)	2008-12-29
PE20040655A1 (es)	2004-11-15
JP4511927B2 (ja)	2010-07-28
NO20050649L (no)	2005-04-01
RU2317300C2 (ru)	2008-02-20
EP1964844B1 (de)	2010-09-01
US20040138143A1 (en)	2004-07-15
SI1523488T1 (sl)	2009-04-30
DE50310783D1 (de)	2008-12-24
EP1523488B1 (de)	2008-11-12
ZA200409779B (en)	2006-06-28
AU2003246620B2 (en)	2009-03-19
IL166058A0 (en)	2006-01-15
CA2493391C (en)	2010-06-15
KR20050021452A (ko)	2005-03-07

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