TWI302442B - Process methods and compositions to treat dysmenorrhea and premenstrual syndrome - Google Patents

Description

1302442 & \ IX, invention description: [Technical field of invention] A functional drink that can relieve menstrual pain and premenstrual syndrome, including functional motherwort, angelica, Chuanxiong, licorice, longan, red dates, dried ginger and sugar Wait for Chinese herbal compound. [Prior Art] It is known that the foods which can relieve menstrual discomfort or premenstrual syndrome are mainly Chinese herbal compound preparations, which are obtained by extracting, refining, boiling or honing various Chinese herbal medicines, respectively, and then extracting the respective extracts or powders. Or a tablet or paste. For example, a menstruation hemostasis agent disclosed in Chinese Patent Publication No. CN1235029 published on November 17, 1999, which contains nine kinds of traditional Chinese medicines including Ejiao, Astragalus, Agrimony, Codonopsis, Angelica, Angelica, Bergamot, Valerian and Continued interruption; and excipients consisting of sugar or lactose alcohol. The CN1235029 patent also discloses a method for manufacturing the medicament, which comprises: (1) extracting volatile oil from two traditional Chinese medicines of angelica and bergamot; (2) crushing the gelatin into medium powder, and crushing the astragalus into fine powder; (3) Angelica and bergamot extract the volatile oil, the sputum of the Astragalus membranaceus, and the Codonopsis pilosula, Radix Paeoniae Alba, Radix Paeoniae Alba, Agrimony, and simmering water; (4) The medicine obtained after extracting the decoction and Angelica and the bergamot to extract the volatile oil The juice is combined and concentrated into a thick paste; (5) the yellow powder of the crude drug is added to the thick paste, mixed, vacuum dried, and pulverized; (6) the powder obtained in (5) is added with gelatin powder, white sugar or lactose. Mix and add the volatile oil extracted from Angelica sinensis and bergamot; then make it into granules, the main function is to improve menstrual disorders. The cure rate disclosed in this patent is 20.25%. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ , Alisma, ginseng, gallnut, atractylodes, scorpion meat, puzzle kernel, squid bone, raspberry, antler, psoralen, Cnidium, Atractylodes, Coix seed, licorice and ginger. The method disclosed by the method is to extract the extracts of Angelica, Chuanxiong, Baiqi, Chishao, Danpi, Astragalus, Atractylodes, Yizhiren, Raspberry, Buguzhi, Cnidium, Atractylodes, Licorice and Ginger with Chinese Yam , 茯苓, 泻, 蔘, gallnut, 瘐 meat and hazelnut powder made into tablets; the main effect is to regulate menstruation, blood, nourishing, warming kidney yang, and Dazhi women through 5 1302442 W * pain, irregular menstruation . For example, it is disclosed in the Chinese Mainland Patent Publication No. CN1244412 published on February 16, 2000, which is composed of frankincense, myrrh, licorice, cinnamon, hawthorn, red dates, yuan meat, gelatin, ginger, Black sugar, honey, lean pork, etc. are made into nine doses. The efficacy revealed by the patent is the treatment of long-term infertility, irregular menstruation, amenorrhea, and anemia. Another example is a traditional Chinese medicine compound preparation gynecological gold tablets disclosed in Chinese Patent Publication No. CN1251763 published on May 3, 2000, which is composed of Angelica, Codonopsis, Andrographis paniculata, Unilateral needle, Golden Sakura, Spatholobus, Top Ten It is composed of merits and merits. The patent also discloses a preparation method thereof, comprising: (1) selecting 9 parts by weight of Angelica sinensis, Codonopsis pilosula, and Andrographis paniculata, pulverizing into fine powder of 100 mesh or more in a pulverizer, and retaining at least 93.3% of the powder yield; (2) Select 9 parts by weight of single-sided needles and 16 parts by weight of sakura root, spatholobus, top ten credits and Chinese herbal medicines, and place them in multi-energy extraction tanks, add hot water, and extract them every 2 hours. The method is extracted twice in one time, and the liquid is collected by filtration; at the same time, the extract is concentrated into a dipstick in a three-effect liquid shrinker for use; (3) the prepared fine powder and the extract are mixed and granulated, and passed through a boiling dryer. It is made into dry granules, and after being tableted and packaged, it is made into a sugar-coated sheet type or a film-coated type of gold-plated sheet. The efficacy of the Chinese medicine disclosed in the patent is dampness, pain relief and menstruation and pain relief. Another example is the maternal lactation rehabilitation Chinese medicine granule disclosed in the Chinese Patent Publication No. CN1255339 published on June 7, 2000, which is composed of Angelica, Pangolin, Sishen, Dangshen, Wang Buliu, Bupleurum, and Astragalus. Lulutong, green skin, platycodon grandiflorum, iron horse whip, Ophiopogon japonicus, and through grass are all made from various flavors of drugs. The traditional Chinese medicine granule has the effects of tonifying qi and nourishing blood, soothing liver and regulating qi, promoting blood circulation, relieving phlegm and blood stasis, regulating menstruation and relieving pain, prolactin and lowering milk. It can treat women with less postpartum milk secretion, no milk, and menstrual discomfort, dysmenorrhea and qi. Blood deficiency, mastitis, hyperplasia of the breast, swelling of the breast and other diseases. — 【Contents】 The known inventions for regulating menstrual discomfort and improving menstrual pain in women are separately processed into several mixed pharmaceutical preparations. Most of the medicaments are lozenges, which are difficult to take off when the traditional Chinese medicine and western medicine tablets have poor mouthfeel. Secondly, the 6 1302442 St ^ Chinese herbal medicines used are extremely numerous, and there may be potential side effects after taking them. The overall processing procedure is complicated, which is not conducive to the quality control. Therefore, it is necessary to develop a simple and simple Chinese medicine. The compound warp-regulating food can not only achieve good process control, but also has a flavor and taste in addition to the effect of regulating the warp. In the traditional Chinese medicine compound pain-regulating functional drink of the present invention, the traditional Chinese medicine compound includes motherwort, angelica, Chuanxiong, licorice, longan, red date, dried ginger and brown sugar. The process includes: (1) soaking the quantitative motherwort, angelica, Chuanxiong, licorice, longan, red dates, dried ginger in water; (2) extracting at high temperature; (3) monitoring the sugar content of the extract (Brix) at any time, when the sugar content is 値When it is greater than 2~4, the extraction is terminated, and all the herbs are filtered out; (4) the extract is concentrated to an extract having a sugar content of more than 7; (5) when the extract is blended into a drink, it is added as 0.4 of the product. ~4% of sugar is made. The main function of the functional drink of the present invention is to relieve the female's main symptoms in the premenstrual syndrome, and to slow down the abdominal pain and to adjust the abnormality of the female physiological period. [Embodiment] In one embodiment of the present invention, 0.25~5% motherwort, 0.2~2% angelica, 0.05~0.5% Chuanxiong, 0.2~1% licorice, 0.1~2% longan, 0.2~1.5% are added first. The combination of jujube, 0.02~0.3% dried ginger, added to water, and extracted at a high temperature of 80-90 ° C for 1 hour, the medicinal material is removed, and then concentrated at a high temperature until the sugar content is greater than 7, the extract is obtained. The extract is then blended with the product and added as 0.4 to 4% brown sugar of the drink. The above extracts were prepared in large quantities according to the law and 40 human subjects were tested. The subjects were those with menstrual pain and started taking them before the premenstrual discomfort. The dosage is 100 ml per day (including 28 ml of sugar 値=7 extract, 3 g of brown sugar, 69 ml of water), and it is taken for 7 consecutive days, and the questionnaire is written before use and after use. Before and after the questionnaire score changes, to assess the symptoms of menstrual discomfort and statistical analysis, the results are as follows: 7 1302442 Verification statistics items 改善 improved after use whether there is a significant difference in lower abdominal cramps 0.032 氺 back pain 0.000 氺 headache 0.022 氺 Abdominal swelling 0.001 氺 Breast pain 0.000 氺 nausea / D area spit 0.413 diarrhea / constipation 0.003 氺 tired to sleep 0.024 氺 糸 糸 / 易 易 0.001 氺 氺 氺 肌肉 0.0 0.0 0.0 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Lower abdominal cramps 0.097 Skin erythema 0.571 Fever / Fear cold 0.115 Frequent urinary 0.041 氺 Indigestion 0.004 This vagina has pus-like secretions 0.048 氺 ΠΤ ΠΤ 量 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.109 (*:p値<0.05 is significantly different) According to the statistical results, for breast pain , neuroticism / irritability, abdominal faint pain, abnormal number of days in the physiological period have improved effects, and statistical analysis has significant differences, in which breast pain, nervousness / irritability are two women in the "premenstrual syndrome" The main symptoms, while the faint pain in the abdomen and the abnormal number of days in the physiological period are the symptoms during the "menstrual period". This human test can alleviate the most common symptoms of women in premenstrual syndrome, and slow down the abdominal pain, as well as the abnormality of the number of days in the physiological period of the female. This result shows that the traditional Chinese medicine compound used in the present invention can effectively relieve menstrual discomfort. 1302442 w > [Simple description of the diagram] Μ j\\\ [Description of main component symbols]

Claims (1)

1302442 * V 令>/^l ifOi: r^:.. X. Patent scope: 1. A functional drink that can relieve menstrual pain and premenstrual syndrome and its preparation method, which is characterized by 0.25 in the Chinese medicine extraction tank ~5% motherwort, 0.2~2% angelica, 0.05~0.5% Chuanxiong, 0.2~1% licorice, 0.1~2% longan, 0.2~1.5% red jujube, 0.02~0.3% dried ginger, added to water, 80~ After extracting at a high temperature of 90 ° C or higher for 1 hour, the medicinal material is removed, and then concentrated at a high temperature until the extract having a sugar content of more than 7 is used, and when the extract is blended into a drink, sugar is added to season. 2. A functional drink capable of soothing menstrual pain and premenstrual syndrome, and a method for preparing the same, wherein the sugar is selected from the group consisting of white sugar, brown sugar, sugar cube, brown sugar or a mixture thereof, wherein the percentage is 0.4~4% of drinks 〇