TWI372757B - Ep2 agonists - Google Patents

Ep2 agonists

Info

Publication number: TWI372757B
Authority: TW; Taiwan
Prior art keywords: agonists
Prior art date: 2006-07-28

Application number

TW096127590A

Other languages

English (en)

Other versions

TW200817360A (en

Inventor

Ganesh Prasanna

Charles Floyd Bosworth

Fontaine Jennifer Anne La

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-28

Filing date

2007-07-27

Publication date

2012-09-21

2007-07-27 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2008-04-16 Publication of TW200817360A publication Critical patent/TW200817360A/zh

2012-09-21 Application granted granted Critical

2012-09-21 Publication of TWI372757B publication Critical patent/TWI372757B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW096127590A 2006-07-28 2007-07-27 Ep2 agonists TWI372757B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83390706P	2006-07-28	2006-07-28
US94192307P	2007-06-04	2007-06-04

Publications (2)

Publication Number	Publication Date
TW200817360A TW200817360A (en)	2008-04-16
TWI372757B true TWI372757B (en)	2012-09-21

Family

ID=38896126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW096127590A TWI372757B (en)	2006-07-28	2007-07-27	Ep2 agonists

Country Status (25)

Country	Link
US (2)	US7622475B2 (zh)
EP (1)	EP2059507B1 (zh)
JP (1)	JP4583500B2 (zh)
KR (1)	KR101088942B1 (zh)
AP (1)	AP2009004754A0 (zh)
AR (1)	AR062122A1 (zh)
AU (1)	AU2007280130B2 (zh)
BR (1)	BRPI0714683A2 (zh)
CA (1)	CA2659184C (zh)
CL (1)	CL2007002207A1 (zh)
CR (1)	CR10554A (zh)
EA (1)	EA200970067A1 (zh)
EC (1)	ECSP099071A (zh)
GT (1)	GT200700064A (zh)
IL (1)	IL196355A0 (zh)
MA (1)	MA30604B1 (zh)
MX (1)	MX2009001062A (zh)
NO (1)	NO20090738L (zh)
NZ (1)	NZ573964A (zh)
PE (1)	PE20080408A1 (zh)
RS (1)	RS20090002A (zh)
TN (1)	TN2009000028A1 (zh)
TW (1)	TWI372757B (zh)
UY (1)	UY30511A1 (zh)
WO (1)	WO2008015517A2 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8648097B2 (en) *	2008-03-12	2014-02-11	Ube Industries, Ltd.	Pyridylaminoacetic acid compound
ES2564010T3 (es)	2009-03-30	2016-03-17	Ube Industries, Ltd.	Composición farmacéutica para tratar o prevenir el glaucoma
JPWO2011030864A1 (ja) *	2009-09-11	2013-02-07	宇部興産株式会社	アニリン化合物
WO2011030865A1 (ja) *	2009-09-11	2011-03-17	宇部興産株式会社	置換ベンジル化合物
EP2476678A4 (en) *	2009-09-11	2013-02-20	Ube Industries	SUBSTITUTED CARBONYL COMPOUNDS
WO2011030873A1 (ja) *	2009-09-11	2011-03-17	宇部興産株式会社	ベンジル化合物
WO2011030872A1 (ja) *	2009-09-11	2011-03-17	宇部興産株式会社	スルホンアミド化合物
WO2011030871A1 (ja) *	2009-09-11	2011-03-17	宇部興産株式会社	Ｎ－置換ヘテロアリール化合物
WO2011078303A1 (ja)	2009-12-25	2011-06-30	宇部興産株式会社	アミノピリジン化合物
EP2605777A1 (en) *	2010-08-17	2013-06-26	Allergan, Inc.	Ep2 or ep4 agonists for treating corneal haze
MX347855B (es)	2011-09-16	2017-05-16	Sanofi Sa	Derivados de anilina, su preparación y su aplicación terapéutica.
HK1210969A1 (zh) *	2012-01-20	2016-05-13	奥克塞拉有限公司	用於疾病治療的取代的雜環化合物
CA2867527A1 (en)	2012-05-03	2013-11-07	Takeda Gmbh	Novel ep2 receptor agonists
US9339496B2 (en) *	2012-07-13	2016-05-17	Santen Pharmaceutical Co., Ltd.	Composition for treating or preventing glaucoma comprising a sulfonamide compound, and a beta-receptor antagonist
RU2015145989A (ru)	2013-03-28	2017-05-16	Убе Индастриз, Лтд.	Замещенное биарильное соединение
JP2017206445A (ja) *	2014-09-26	2017-11-24	宇部興産株式会社	呼吸器疾患の治療及び／又は予防のための医薬組成物
JP2017206443A (ja) *	2014-09-26	2017-11-24	宇部興産株式会社	置換ビアリール化合物及び他の医薬の組み合わせ
TWI755356B (zh) *	2015-07-01	2022-02-21	日商參天製藥股份有限公司	含檸檬酸酯之緩釋劑之用途
JP2019513010A (ja)	2016-03-04	2019-05-23	ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー	プロスタグランジンｅ２を用いる、筋再生のための組成物および方法
WO2018227134A1 (en)	2017-06-09	2018-12-13	The Board Of Trustees Of The Leland Stanford Junior University	Compositions and methods for preventing or treating muscle conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4599353A (en)	1982-05-03	1986-07-08	The Trustees Of Columbia University In The City Of New York	Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US5296504A (en)	1988-09-06	1994-03-22	Kabi Pharmacia	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
UA59384C2 (uk)	1996-12-20	2003-09-15	Пфайзер, Інк.	Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
UA67754C2 (uk) *	1997-10-10	2004-07-15	Пфайзер, Інк.	Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
EP1000619A3 (en)	1998-06-23	2002-07-24	Pfizer Products Inc.	Method for treating glaucoma
EP1108426A3 (en)	1999-12-02	2002-10-02	Pfizer Products Inc.	Use of prostaglandin agonists to treat erectile dysfunction or impotence
US20020161026A1 (en)	2000-11-07	2002-10-31	Paralkar Vishwas M.	Combination therapies for the stimulation of bone growth
BR0214614A (pt)	2001-11-30	2004-09-14	Pfizer Prod Inc	Composições farmacêuticas e métodos para a administração de agonistas seletivos de receptor ep2
HUP0500012A2 (hu) *	2002-01-31	2005-04-28	Pfizer Products Inc.	A (3-{[4-terc-butil-benzil)-(piridin-3-szulfonil)-amino]-metil}-fenoxi)-ecetsav metabolitjai és ezeket hatóanyagként tartalmazó gyógyszerkészítmények
AU2004216898A1 (en)	2003-03-04	2004-09-16	Pfizer Products Inc.	Use of EP2 selective receptor agonists in medical treatment
US20050203086A1 (en)	2004-03-04	2005-09-15	Pfizer Inc.	Methods of treatment using an EP2 selective receptor agonist
US7915316B2 (en) *	2005-08-22	2011-03-29	Allergan, Inc	Sulfonamides
US7696235B2 (en) *	2005-08-29	2010-04-13	Allergan, Inc.	EP2 receptor agonists for treating glaucoma

2007
- 2007-07-16 JP JP2009522350A patent/JP4583500B2/ja not_active Expired - Fee Related
- 2007-07-16 EP EP07766635A patent/EP2059507B1/en not_active Not-in-force
- 2007-07-16 CA CA2659184A patent/CA2659184C/en not_active Expired - Fee Related
- 2007-07-16 AU AU2007280130A patent/AU2007280130B2/en not_active Ceased
- 2007-07-16 BR BRPI0714683-3A patent/BRPI0714683A2/pt not_active IP Right Cessation
- 2007-07-16 NZ NZ573964A patent/NZ573964A/en not_active IP Right Cessation
- 2007-07-16 KR KR1020097001522A patent/KR101088942B1/ko not_active Expired - Fee Related
- 2007-07-16 RS RSP-2009/0002A patent/RS20090002A/sr unknown
- 2007-07-16 MX MX2009001062A patent/MX2009001062A/es active IP Right Grant
- 2007-07-16 EA EA200970067A patent/EA200970067A1/ru unknown
- 2007-07-16 AP AP2009004754A patent/AP2009004754A0/xx unknown
- 2007-07-16 WO PCT/IB2007/002044 patent/WO2008015517A2/en not_active Ceased
- 2007-07-26 AR ARP070103330A patent/AR062122A1/es unknown
- 2007-07-26 PE PE2007000967A patent/PE20080408A1/es not_active Application Discontinuation
- 2007-07-27 US US11/829,176 patent/US7622475B2/en not_active Expired - Fee Related
- 2007-07-27 UY UY30511A patent/UY30511A1/es not_active Application Discontinuation
- 2007-07-27 CL CL200702207A patent/CL2007002207A1/es unknown
- 2007-07-27 TW TW096127590A patent/TWI372757B/zh not_active IP Right Cessation
- 2007-07-27 GT GT200700064A patent/GT200700064A/es unknown
2009
- 2009-01-05 IL IL196355A patent/IL196355A0/en unknown
- 2009-01-13 CR CR10554A patent/CR10554A/es not_active Application Discontinuation
- 2009-01-14 EC EC2009009071A patent/ECSP099071A/es unknown
- 2009-01-26 TN TN2009000028A patent/TN2009000028A1/fr unknown
- 2009-01-28 MA MA31593A patent/MA30604B1/fr unknown
- 2009-02-16 NO NO20090738A patent/NO20090738L/no not_active Application Discontinuation
- 2009-10-07 US US12/575,373 patent/US20100105905A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ECSP099071A (es)	2009-02-27
PE20080408A1 (es)	2008-04-28
MA30604B1 (fr)	2009-07-01
EA200970067A1 (ru)	2009-08-28
TN2009000028A1 (fr)	2010-08-19
EP2059507B1 (en)	2013-03-20
WO2008015517A3 (en)	2008-06-12
TW200817360A (en)	2008-04-16
CA2659184C (en)	2012-02-21
NO20090738L (no)	2009-04-27
WO2008015517A2 (en)	2008-02-07
US7622475B2 (en)	2009-11-24
BRPI0714683A2 (pt)	2013-03-26
CA2659184A1 (en)	2008-02-07
US20080045545A1 (en)	2008-02-21
JP4583500B2 (ja)	2010-11-17
HK1133876A1 (zh)	2010-04-09
AU2007280130B2 (en)	2011-09-22
UY30511A1 (es)	2008-02-29
US20100105905A1 (en)	2010-04-29
CR10554A (es)	2009-02-10
JP2009544751A (ja)	2009-12-17
RS20090002A (sr)	2010-06-30
EP2059507A2 (en)	2009-05-20
KR20090023507A (ko)	2009-03-04
AP2009004754A0 (en)	2009-02-28
AR062122A1 (es)	2008-10-15
CL2007002207A1 (es)	2008-02-01
AU2007280130A1 (en)	2008-02-07
IL196355A0 (en)	2009-09-22
MX2009001062A (es)	2009-02-06
GT200700064A (es)	2009-06-18
NZ573964A (en)	2010-11-26
KR101088942B1 (ko)	2011-12-01

Publication	Publication Date	Title
TWI372757B (en)	2012-09-21	Ep2 agonists
IL199019A0 (en)	2010-02-17	Acylaminopyrazoles as fgfr inhibitors
GB0709295D0 (en)	2007-06-20	New Zealander
IL192799A0 (en)	2009-02-11	Substituted 4-phenylpiperidines
GB0708226D0 (en)	2007-06-06	Y-receptor agonists
PL1973884T3 (pl)	2017-05-31	Nowe związki heterocykliczne
EP2080799A4 (en)	2011-07-27	LUBRICATING GREASE
EP2069339A4 (en)	2010-01-20	SUBSTITUTED PIPERIDINOPHENYLOXAZOLIDINONE
AP2008004724A0 (en)	2008-12-31	Substituted1-yl)-azolin-2-aryl-1-hetaryl-ethane
ZA200900611B (en)	2010-07-28	EP2 agonists
ZA200903382B (en)	2010-04-28	Substituted 4-imidazoles
EP2068747A4 (en)	2012-11-28	DENTISTRY INSULATOR
EP1973351A4 (en)	2012-12-26	MONITOR
ZA200708752B (en)	2009-04-29	Component
GB0714941D0 (en)	2007-09-12	Inhibitors
GB0614580D0 (en)	2006-08-30	Agonists 1A
GB0614578D0 (en)	2006-08-30	Agonists IIA
GB0516439D0 (en)	2005-09-14	EP2 receptor agonists
SI2029547T1 (sl)	2010-09-30	Agonisti fxr farnezoid x receptorja
HU0600193V0 (en)	2006-10-30	Latch-cover for water-network
GB0612494D0 (en)	2006-08-02	Lubricant
PL379595A1 (pl)	2007-11-12	Środek smarny
AU314666S (en)	2007-06-14	Recessed unit
GB0602474D0 (en)	2006-03-22	Bearings
HU0600147V0 (en)	2006-08-28	Monitor

Legal Events

Date	Code	Title	Description
2014-06-21	MM4A	Annulment or lapse of patent due to non-payment of fees