TWI370135B - Analogs of ghrelin substituted at the n-terminal - Google Patents

Analogs of ghrelin substituted at the n-terminal

Info

Publication number: TWI370135B
Authority: TW; Taiwan
Prior art keywords: ghrelin; analogs; substituted; terminal; ghrelin substituted
Prior art date: 2006-09-27

Application number

TW096135656A

Other languages

English (en)

Other versions

TW200821328A (en

Inventor

Zheng Xin Dong

Original Assignee

Ipsen Pharma Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-27

Filing date

2007-09-26

Publication date

2012-08-11

2007-09-26 Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas

2008-05-16 Publication of TW200821328A publication Critical patent/TW200821328A/zh

2012-08-11 Application granted granted Critical

2012-08-11 Publication of TWI370135B publication Critical patent/TWI370135B/zh

Links

102000012004 Ghrelin Human genes 0.000 title 1
101800001586 Ghrelin Proteins 0.000 title 1
GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical group C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Pulmonology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Obesity (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Nutrition Science (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Heart & Thoracic Surgery (AREA)

TW096135656A 2006-09-27 2007-09-26 Analogs of ghrelin substituted at the n-terminal TWI370135B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84742306P	2006-09-27	2006-09-27

Publications (2)

Publication Number	Publication Date
TW200821328A TW200821328A (en)	2008-05-16
TWI370135B true TWI370135B (en)	2012-08-11

Family

ID=39230783

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW096135656A TWI370135B (en)	2006-09-27	2007-09-26	Analogs of ghrelin substituted at the n-terminal

Country Status (16)

Country	Link
US (1)	US8299022B2 (zh)
EP (1)	EP2083842B1 (zh)
JP (1)	JP5134627B2 (zh)
KR (1)	KR101197541B1 (zh)
CN (1)	CN101541341B (zh)
AR (1)	AR061780A1 (zh)
AU (1)	AU2007300526B2 (zh)
BR (1)	BRPI0717169C1 (zh)
CA (1)	CA2664558C (zh)
ES (1)	ES2436419T3 (zh)
IL (1)	IL197796A (zh)
MX (1)	MX2009003246A (zh)
NZ (1)	NZ576470A (zh)
RU (1)	RU2459831C2 (zh)
TW (1)	TWI370135B (zh)
WO (1)	WO2008039415A2 (zh)

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JP4896140B2 (ja) *	2005-09-28	2012-03-14	イプセンファルマソシエテパールアクシオンサンプリフィエ	グレリンの類似体
PL1937262T3 (pl)	2005-09-29	2019-10-31	Ipsen Pharma	Kompozycja do stosowania w leczeniu zaburzeń motoryki przewodu pokarmowego
KR101623985B1 (ko)	2007-03-28	2016-05-25	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	스티칭된 폴리펩티드
US9724381B2 (en) *	2009-05-12	2017-08-08	The Administrators Of The Tulane Educational Fund	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US9526648B2 (en)	2010-06-13	2016-12-27	Synerz Medical, Inc.	Intragastric device for treating obesity
US8628554B2 (en)	2010-06-13	2014-01-14	Virender K. Sharma	Intragastric device for treating obesity
US10420665B2 (en)	2010-06-13	2019-09-24	W. L. Gore & Associates, Inc.	Intragastric device for treating obesity
US10010439B2 (en)	2010-06-13	2018-07-03	Synerz Medical, Inc.	Intragastric device for treating obesity
ES2711526T3 (es)	2010-08-13	2019-05-06	Aileron Therapeutics Inc	Macrociclos peptidomiméticos
AU2012326026B2 (en)	2011-10-18	2017-04-13	Aileron Therapeutics, Inc.	Peptidomimetic macrocyles
JP2015510505A (ja) *	2012-02-03	2015-04-09	ジーランドファーマアクティーゼルスカブ	グレリン類似体
US10039813B2 (en)	2012-02-07	2018-08-07	Massachusetts Institute Of Technology	Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
US8987414B2 (en)	2012-02-15	2015-03-24	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2013123266A1 (en)	2012-02-15	2013-08-22	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
TWI667024B (zh)	2012-09-27	2019-08-01	美商雅瑞塔那醫療公司	使用食慾喪失控制化合物之組合物及方法
CA2887285A1 (en)	2012-11-01	2014-05-08	Aileron Therapeutics, Inc.	Disubstituted amino acids and methods of preparation and use thereof
US9724396B2 (en)	2013-03-15	2017-08-08	Massachusetts Institute Of Technology	Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
TWI662967B (zh) *	2013-03-25	2019-06-21	日商志瑞亞新藥工業股份有限公司	食後期之胃運動亢進劑
CN106459149A (zh) *	2014-03-04	2017-02-22	莫图斯治疗公司	H‑inp‑(d)bal‑(d)trp‑phe‑apc‑nh2及其可药用盐的液相合成的方法
CN106999541A (zh)	2014-09-24	2017-08-01	艾瑞朗医疗公司	拟肽大环化合物及其用途
MX383741B (es)	2015-01-28	2025-03-04	Aratana Therapeutics Inc	Composiciones y métodos para el uso crónico de un compuesto para aumentar el peso.
WO2016138099A1 (en)	2015-02-24	2016-09-01	Massachusetts Institute Of Technology	Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
CN107614003A (zh)	2015-03-20	2018-01-19	艾瑞朗医疗公司	拟肽大环化合物及其用途
US10779980B2 (en)	2016-04-27	2020-09-22	Synerz Medical, Inc.	Intragastric device for treating obesity
WO2021261966A1 (ko) *	2020-06-26	2021-12-30	숙명여자대학교 산학협력단	사이클로덱스트린을 이용한 경구투여용 복합 조성물 및 이의 제조방법
WO2023161226A1 (en) *	2022-02-22	2023-08-31	Pephexia Therapeutics Aps	Ghrelin agonists with improved potency
WO2024003381A1 (en) *	2022-07-01	2024-01-04	Pephexia Therapeutics Aps	Hybrid polypeptides acting as dual ghsr and npy5r agonists

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US6124263A (en)	1998-11-16	2000-09-26	Asta Medica Ag	Treatment of tumors by administration of growth hormone releasing compounds and their antagonists
EP1795598B1 (en)	1999-07-23	2009-11-18	Kenji Kangawa	Novel peptides
WO2001092292A2 (en) *	2000-05-30	2001-12-06	Merck & Co., Inc.	Ghrelin analogs
BR0306685A (pt) *	2002-05-21	2005-04-26	Daiichi Suntory Pharma Co Ltd	Composição farmacêutica contendo grelina
TWI325003B (en) *	2002-07-23	2010-05-21	Sod Conseils Rech Applic	Ghrelin analogs
TWI331922B (en) *	2002-08-09	2010-10-21	Ipsen Pharma Sas	Growth hormone releasing peptides
ES2300686T3 (es) *	2003-10-16	2008-06-16	F. Hoffmann-La Roche Ag	Peptidos sw grelina marcados fluorescentemente.
JP4896140B2 (ja)	2005-09-28	2012-03-14	イプセンファルマソシエテパールアクシオンサンプリフィエ	グレリンの類似体
ES2424970T3 (es) *	2006-03-10	2013-10-10	Ipsen Pharma	Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides

2007
- 2007-09-24 CN CN2007800436254A patent/CN101541341B/zh not_active Expired - Fee Related
- 2007-09-24 BR BRC10717169-2A patent/BRPI0717169C1/pt not_active IP Right Cessation
- 2007-09-24 WO PCT/US2007/020595 patent/WO2008039415A2/en not_active Ceased
- 2007-09-24 ES ES07838741.2T patent/ES2436419T3/es active Active
- 2007-09-24 RU RU2009115711/04A patent/RU2459831C2/ru not_active IP Right Cessation
- 2007-09-24 CA CA2664558A patent/CA2664558C/en not_active Expired - Fee Related
- 2007-09-24 NZ NZ576470A patent/NZ576470A/xx not_active IP Right Cessation
- 2007-09-24 AU AU2007300526A patent/AU2007300526B2/en not_active Ceased
- 2007-09-24 EP EP07838741.2A patent/EP2083842B1/en active Active
- 2007-09-24 JP JP2009530382A patent/JP5134627B2/ja not_active Expired - Fee Related
- 2007-09-24 US US12/311,409 patent/US8299022B2/en not_active Expired - Fee Related
- 2007-09-24 KR KR1020097008570A patent/KR101197541B1/ko not_active Expired - Fee Related
- 2007-09-24 MX MX2009003246A patent/MX2009003246A/es active IP Right Grant
- 2007-09-26 TW TW096135656A patent/TWI370135B/zh not_active IP Right Cessation
- 2007-09-26 AR ARP070104255A patent/AR061780A1/es not_active Application Discontinuation
2009
- 2009-03-25 IL IL197796A patent/IL197796A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
BRPI0717169C1 (pt)	2012-12-04
NZ576470A (en)	2012-09-28
BRPI0717169A2 (pt)	2012-10-23
KR20090075838A (ko)	2009-07-09
CN101541341A (zh)	2009-09-23
CA2664558A1 (en)	2008-04-03
CA2664558C (en)	2016-11-01
AU2007300526A1 (en)	2008-04-03
TW200821328A (en)	2008-05-16
KR101197541B1 (ko)	2013-01-02
MX2009003246A (es)	2009-07-29
AU2007300526B2 (en)	2011-07-21
CN101541341B (zh)	2013-06-05
WO2008039415A2 (en)	2008-04-03
EP2083842B1 (en)	2013-08-28
IL197796A (en)	2015-09-24
AR061780A1 (es)	2008-09-24
RU2009115711A (ru)	2010-11-10
IL197796A0 (en)	2011-08-01
JP5134627B2 (ja)	2013-01-30
US20090275511A1 (en)	2009-11-05
JP2010504966A (ja)	2010-02-18
RU2459831C2 (ru)	2012-08-27
US8299022B2 (en)	2012-10-30
EP2083842A4 (en)	2011-03-16
EP2083842A2 (en)	2009-08-05
ES2436419T3 (es)	2014-01-02
WO2008039415A3 (en)	2008-11-13

Publication	Publication Date	Title
TWI370135B (en)	2012-08-11	Analogs of ghrelin substituted at the n-terminal
HUS1900033I1 (hu)	2019-07-29	Szubsztituált enaminokarbonil vegyületek
IL194120A0 (en)	2011-08-01	Stabilized polypeptide compositions
ZA200810738B (en)	2018-11-28	Polypeptide
ZA200904445B (en)	2010-12-29	Cyclopamine analogs
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