TWI349557B - Use of hpv 16 and hpv 18 vlps for vaccine preparation - Google Patents

Use of hpv 16 and hpv 18 vlps for vaccine preparation

Info

Publication number: TWI349557B
Authority: TW; Taiwan
Prior art keywords: hpv; vlps; vaccine preparation; vaccine; preparation
Prior art date: 2002-12-20

Application number

TW092135963A

Other languages

English (en)

Other versions

TW200423957A (en

Inventor

Gary Dubin

Bruce Innis

Moncef Mohammed Slaoui

Martine Anne Cecile Wettendorff

Original Assignee

Glaxosmithkline Biolog Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-20

Filing date

2003-12-18

Publication date

2011-10-01

2003-12-18 Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa

2004-11-16 Publication of TW200423957A publication Critical patent/TW200423957A/zh

2011-10-01 Application granted granted Critical

2011-10-01 Publication of TWI349557B publication Critical patent/TWI349557B/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

TW092135963A 2002-12-20 2003-12-18 Use of hpv 16 and hpv 18 vlps for vaccine preparation TWI349557B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43503502P	2002-12-20	2002-12-20
US49665303P	2003-08-20	2003-08-20

Publications (2)

Publication Number	Publication Date
TW200423957A TW200423957A (en)	2004-11-16
TWI349557B true TWI349557B (en)	2011-10-01

Family

ID=32685362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW092135963A TWI349557B (en)	2002-12-20	2003-12-18	Use of hpv 16 and hpv 18 vlps for vaccine preparation

Country Status (28)

Country	Link
US (2)	US20060251676A1 (zh)
EP (1)	EP1572233B1 (zh)
JP (1)	JP5475939B2 (zh)
KR (3)	KR20050086924A (zh)
AP (1)	AP2005003347A0 (zh)
AR (1)	AR042530A1 (zh)
AT (1)	ATE503492T1 (zh)
AU (1)	AU2003293942B2 (zh)
BE (3)	BE2015C068I2 (zh)
BR (1)	BR0317544A (zh)
CA (1)	CA2510457C (zh)
CY (1)	CY1111552T1 (zh)
DE (1)	DE60336581D1 (zh)
DK (1)	DK1572233T3 (zh)
EA (2)	EA200701633A1 (zh)
EC (1)	ECSP055869A (zh)
IL (1)	IL169085A (zh)
IS (1)	IS2811B (zh)
MA (1)	MA27581A1 (zh)
MX (1)	MXPA05006764A (zh)
MY (1)	MY144492A (zh)
NO (1)	NO20052846L (zh)
NZ (1)	NZ540811A (zh)
OA (1)	OA13147A (zh)
PL (1)	PL215257B1 (zh)
PT (1)	PT1572233E (zh)
TW (1)	TWI349557B (zh)
WO (1)	WO2004056389A1 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1126876T3 (da)	1998-10-16	2007-07-02	Glaxosmithkline Biolog Sa	Adjuvanssystemer og vacciner
GB0206360D0 (en)	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
US7858098B2 (en)	2002-12-20	2010-12-28	Glaxosmithkline Biologicals, S.A.	Vaccine
US7758866B2 (en)	2004-06-16	2010-07-20	Glaxosmithkline Biologicals, S.A.	Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
CA2566620C (en) *	2004-06-16	2014-03-11	Glaxosmithkline Biologicals S.A.	Vaccine against hpv16 and hpv18 and at least another hpv type slected from hpv 31, 45 or 52
WO2006113209A1 (en)	2005-04-15	2006-10-26	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
MX2007013475A (es) *	2005-04-26	2008-04-02	Glaxosmithkline Biolog Sa	Vacuna.
WO2006114312A2 (en) *	2005-04-26	2006-11-02	Glaxosmithkline Biologicals S.A.	Vaccine
CN101570571B (zh)	2007-04-29	2012-07-11	北京万泰生物药业股份有限公司	截短的人乳头瘤病毒18型l1蛋白
US9428555B2 (en)	2007-04-29	2016-08-30	Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.	Truncated L1 protein of Human Papillomavirus type 16
EP2403507B1 (en)	2009-03-05	2018-02-21	McCloskey, Jenny Colleen	Treatment of infection
KR101181907B1 (ko) *	2009-06-19	2012-09-11	아이진 주식회사	자궁경부암 백신
CN106461667A (zh)	2014-01-31	2017-02-22	乌利塞生物医药公司	用于检测感染及相关病症的生物传感器
US10799574B2 (en)	2014-10-24	2020-10-13	Hpvvax. Llc	Method and composition for treating cancer or skin lesion using a vaccine
EP3209676A4 (en)	2014-10-24	2018-03-28	Hpvvax, Llc	Cancer and skin lesion treatment
AU2016273638B2 (en) *	2015-06-02	2019-06-06	Terumo Kabushiki Kaisha	Adjuvant composition containing aluminum and vaccine composition containing the same
SG11202008539YA (en)	2018-03-06	2020-10-29	Precigen Inc	Human papillomavirus vaccines and uses of the same
KR20200128703A (ko)	2018-03-06	2020-11-16	프레시전 인코포레이티드	B형 간염 백신 및 이의 용도
EP3812395A4 (en) *	2018-06-04	2022-03-30	Xiamen University	MUTANT OF HUMAN PAPILLOMAVIRUS TYPE 18 L1 PROTEIN
KR20210100115A (ko)	2018-12-03	2021-08-13	보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템	올리고-벤즈아미드 유사체 및 암 치료에서의 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4332596A1 (de) *	1993-09-24	1995-03-30	Martin Josef Dr Sapp	Monoklonale Antikörper
EP1015561B1 (en)	1997-09-05	2006-07-19	Medimmune, Inc.	In vitro method for disassembly/reassembly of papillomavirus virus-like particles (vlps)
ES2313881T3 (es) *	1999-02-05	2009-03-16	MERCK & CO., INC.	Formulaciones de vacunas frente al papilomavirus humano.
US6245568B1 (en)	1999-03-26	2001-06-12	Merck & Co., Inc.	Human papilloma virus vaccine with disassembled and reassembled virus-like particles
GB9921146D0 (en) *	1999-09-07	1999-11-10	Smithkline Beecham Biolog	Novel composition
US6908613B2 (en) *	2000-06-21	2005-06-21	Medimmune, Inc.	Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
IL153474A0 (en) *	2000-06-26	2003-07-06	Stressgen Biotechnologies Corp	Human papilloma virus treatment

2003
- 2003-12-18 AU AU2003293942A patent/AU2003293942B2/en not_active Expired
- 2003-12-18 WO PCT/EP2003/014562 patent/WO2004056389A1/en not_active Ceased
- 2003-12-18 MX MXPA05006764A patent/MXPA05006764A/es active IP Right Grant
- 2003-12-18 PL PL377710A patent/PL215257B1/pl unknown
- 2003-12-18 KR KR1020057011497A patent/KR20050086924A/ko not_active Ceased
- 2003-12-18 DK DK03789346.8T patent/DK1572233T3/da active
- 2003-12-18 DE DE60336581T patent/DE60336581D1/de not_active Expired - Lifetime
- 2003-12-18 JP JP2005502554A patent/JP5475939B2/ja not_active Expired - Lifetime
- 2003-12-18 EA EA200701633A patent/EA200701633A1/ru unknown
- 2003-12-18 EP EP03789346A patent/EP1572233B1/en not_active Expired - Lifetime
- 2003-12-18 US US10/540,099 patent/US20060251676A1/en not_active Abandoned
- 2003-12-18 OA OA1200500189A patent/OA13147A/en unknown
- 2003-12-18 TW TW092135963A patent/TWI349557B/zh not_active IP Right Cessation
- 2003-12-18 CA CA2510457A patent/CA2510457C/en not_active Expired - Lifetime
- 2003-12-18 AT AT03789346T patent/ATE503492T1/de active
- 2003-12-18 PT PT03789346T patent/PT1572233E/pt unknown
- 2003-12-18 AR ARP030104709A patent/AR042530A1/es unknown
- 2003-12-18 BR BR0317544-8A patent/BR0317544A/pt not_active Application Discontinuation
- 2003-12-18 KR KR1020127026719A patent/KR20120118087A/ko not_active Withdrawn
- 2003-12-18 KR KR1020127027784A patent/KR101361769B1/ko not_active Expired - Lifetime
- 2003-12-18 NZ NZ540811A patent/NZ540811A/en not_active IP Right Cessation
- 2003-12-18 MY MYPI20034868A patent/MY144492A/en unknown
- 2003-12-18 AP AP2005003347A patent/AP2005003347A0/xx unknown
- 2003-12-18 EA EA200500834A patent/EA009179B1/ru not_active IP Right Cessation
2005
- 2005-04-26 US US11/114,301 patent/US20050287161A1/en not_active Abandoned
- 2005-06-09 IS IS7885A patent/IS2811B/is unknown
- 2005-06-09 IL IL169085A patent/IL169085A/en active IP Right Grant
- 2005-06-13 NO NO20052846A patent/NO20052846L/no not_active Application Discontinuation
- 2005-06-20 EC EC2005005869A patent/ECSP055869A/es unknown
- 2005-07-18 MA MA28398A patent/MA27581A1/fr unknown
2011
- 2011-06-08 CY CY20111100549T patent/CY1111552T1/el unknown
2015
- 2015-12-09 BE BE2015C068C patent/BE2015C068I2/fr unknown
- 2015-12-09 BE BE2015C069C patent/BE2015C069I2/fr unknown
- 2015-12-09 BE BE2015C067C patent/BE2015C067I2/fr unknown

Also Published As

Publication number	Publication date
PL215257B1 (pl)	2013-11-29
JP5475939B2 (ja)	2014-04-16
ECSP055869A (es)	2005-09-20
ATE503492T1 (de)	2011-04-15
CA2510457C (en)	2011-12-06
EA200701633A1 (ru)	2007-12-28
PL377710A1 (pl)	2006-02-06
EP1572233A1 (en)	2005-09-14
BE2015C067I2 (zh)	2024-08-08
MXPA05006764A (es)	2005-09-08
IS2811B (is)	2012-11-15
KR20120123616A (ko)	2012-11-08
HK1085378A1 (zh)	2006-08-25
WO2004056389A1 (en)	2004-07-08
DK1572233T3 (da)	2011-06-27
CY1111552T1 (el)	2015-08-05
EA200500834A1 (ru)	2006-02-24
TW200423957A (en)	2004-11-16
KR20120118087A (ko)	2012-10-25
BR0317544A (pt)	2005-11-22
US20050287161A1 (en)	2005-12-29
AR042530A1 (es)	2005-06-22
BE2015C068I2 (zh)	2024-08-08
BE2015C069I2 (zh)	2024-08-08
US20060251676A1 (en)	2006-11-09
OA13147A (en)	2006-12-13
MA27581A1 (fr)	2005-10-03
AU2003293942A1 (en)	2004-07-14
PT1572233E (pt)	2011-06-07
IL169085A (en)	2014-04-30
DE60336581D1 (de)	2011-05-12
KR20050086924A (ko)	2005-08-30
CA2510457A1 (en)	2004-07-08
MY144492A (en)	2011-09-30
EP1572233B1 (en)	2011-03-30
AU2003293942B2 (en)	2009-12-10
NO20052846L (no)	2005-07-13
KR101361769B1 (ko)	2014-02-10
IL169085A0 (en)	2007-07-04
AP2005003347A0 (en)	2005-06-30
NZ540811A (en)	2007-03-30
IS7885A (is)	2005-06-09
JP2006512413A (ja)	2006-04-13
EA009179B1 (ru)	2007-12-28

Publication	Publication Date	Title
TWI349557B (en)	2011-10-01	Use of hpv 16 and hpv 18 vlps for vaccine preparation
AP2004003136A0 (en)	2004-09-30	Virus-like particles of human papillomavirus
ZA200502618B (en)	2008-10-29	Human papillomavirus polypeptides and immunogenic compositions
IL158107A0 (en)	2004-03-28	Human papillomaviruses vaccine
HUP0204250A3 (en)	2005-06-28	Use of hiv-protein or -polynucleotide for vaccine produce
AU2003227533A8 (en)	2003-09-29	Virus like particle from papillomavirus and their use in vaccine
AU2001241918A1 (en)	2001-09-12	Methods of enhancing activity of vaccines and vaccine compositions
TWI339662B (en)	2011-04-01	Arylvinylazacycloalkane compounds and methods of preparation and use thereof
IL162381A0 (en)	2005-11-20	A recombinant dna construct and a process for the preparation of a non-toxic anthrax vaccine
IL159067A0 (en)	2004-05-12	METHODS FOR PREPARATION AND USE OF 1alpha,24 (S) -DIHYDROXYVITAMIN D2
ZA200601991B (en)	2009-08-26	Process for the preparation of renzapride and intermediates thereof
AU2003290012A1 (en)	2004-06-30	L2-peptide of the human papillomavirus associated with virus-like particles
EP1617810A4 (en)	2007-07-11	PROCESS FOR THE PREPARATION AND USE OF 1ALPHA, 24 (S) -DIHYDROXYVITAMINE D2
IL174325A0 (en)	2008-04-13	Dna vaccine compositions and methods of use
GB0200258D0 (en)	2002-02-20	Detection of human papillomavirus
EP1439845A4 (en)	2004-12-08	INACTIVATION OF THE PAPILLOMA
SI1572233T1 (sl)	2011-07-29	Uporaba HPV16 in HPV18 kot cepivo proti enemu ali več onkogenih HPV tipa 31,33,35,39,45,51,52,56,58,59,66,68
AU2002356763A1 (en)	2003-06-10	Use of a technically modified cell as a vaccine for treating tumoral disease
GB0105606D0 (en)	2001-04-25	Immunogens and vaccines and their preparation and use
AU2002333157A1 (en)	2004-03-29	Compound for treatment of anxiety and methods of preparation and use thereof
AU2003239773A1 (en)	2004-01-19	Preparation of vaccines
AU2003281909A1 (en)	2004-06-03	Method of obtaining conjugate vaccines and vaccine compositions containing same
AU2003249364A8 (en)	2004-01-06	Algal gdp-mannose-3',5'-epimerases and methods of use thereof
AU2003264311A1 (en)	2004-04-08	Oral formulations of ibuprofen and tramadol, methods and preparation thereof
HK1072378A (zh)	2005-08-26	人乳头瘤病毒的类病毒颗粒

Legal Events

Date	Code	Title	Description
2024-02-01	MK4A	Expiration of patent term of an invention patent