TWI248950B - Process for preparing porous material having interconnected pores - Google Patents

Abstract

The present invention provides a process for preparing a porous material having interconnected pores. One or more than one bioresorbable polymer and a low molecular weight oligomer are dissolved in an organic solvent to form a bioresorbable polymer solution. Then, the bioresorbable polymer solution is caused to form a pre-form. Then, drying is conducted to partially or completely remove the organic solvent on the pre-form surface. Then, the pre-form is contacted with a coagulant to form a porous material.

Description

1248950 玖Invention Description: [Technical Field] The present invention relates to a method for preparing a porous material having mutually interconnected pores, and more particularly to using a low molecular weight oligopolymer as a pore forming agent after formation of a preform A method of preparing a porous material having an interconnected pore structure by drying it before contacting the coagulating liquid. [Prior Art] In the case of surgery and surgery, in order to fix the soft ssue or hard tissue of the human body, the surgeon must use an implantation device or materials. The device or material implanted in the human tissue, after a period of time after the operation, when the soft tissue or hard tissue of the human body has reached a heal ing state, if the implant material used is a bioabsorbable material, the physician In order to avoid the formation of foreign objects in these materials or their devices, a second procedure is often required to remove these implanted materials from the body. In addition to the medical resources, the second surgery also increases the patient's suffering and the risk of accidents that may occur during the second surgery. Therefore, the use of bioabsorbable materials has become the preferred choice for modern clinical medicine for use in biomedical materials. There are many types of Synthetic bioabsorbable polymers that have been used in clinical medicine, such as p〇lyglyc〇lic acid (PGA) (polyglycolic acid), polylactic acid (PLA) (polylactic acid). , 0〇17(忌1丫(:〇11(:-(:〇-1&(:1:]^&(^〇1)(?1^八)[poly(glycolic acid-co-lactic acid) ], polycaprolactone (PCL) (polycaprolactone), polydioxanone (polydioxanone), etc. There are also many types of naturally occurring bioabsorbable polymer materials, such as: collagen (c〇llagen), gelatin 1248950 (gelatin), silk (si Ik), chi tosan, chitin, alginate, hyaluronic acid, chondroitin sulphate, etc. The bioabsorbable polymer can be made into a final implanted biomedical material or a derivative device thereof by various processing techniques. In some clinical applications, the bioabsorbable polymer can be processed into a porous body. The porous matrix is implanted into the patient and the porosity of these implants The substrate provides a temporary barrier between tissues and organs in the body, or serves as a temporary tissue organ for fixation or support. In some clinical applications, the porous substrate can also be directly implanted into a patient. These implanted porous substrates provide soft tissue or hard tissue in which the in vivo cellular tissue is gradually grown into the in-growth porous substrate to grow new tissue to repair defects in the patient's body. The porous morphology of the implanted porous substrate must in principle be interconnected so that the cells can grow into the interior. Furthermore, the interactively connected pore pattern can The growing cells inside the substrate obtain nutrients and allow the cell metabolites to be discharged outside the porous substrate. Further, these porous substrates implanted in the body are desirably bioabsorbable. It will reduce the problem of foreign body reaction due to the implantation of porous materials into human tissues. In the technology of today's biomedical materials, There are many methods for preparing porous substrates, each having its own characteristics and limitations. The methods that can be found in the general literature generally include (1) solution casting, and (2) solvent casting salt washing (solvent- Casting particulate leaching), (3) gel casting, (4) gas saturation, (5) phase separation, (6) bonded fiber (7) particle sintering, (8) adding a foaming 1248950 foaming agent or the like.

Markus S. Widmer et al. C Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration", Biomaterials, 19, P1945-1955, 1998) and G. R. D. Evans et al. ("In vivo evaluation of poly (1-lactic acid) porous conduits for peripheral nerve regeneration", Biomaterials, 20, pll09-1115, 1999) using PLGA and PLLA bioabsorbable materials, dissolved in MC (Methylene chloride) solvent, and then added to grinded After the salt is stirred evenly, it is cooled and cut into small pieces, and then extruded into a hollow circular tube by using a piston type extruder. The tube is cut and placed in water for 24 hours to form a porous round tube. J·H· deGroot et al. Human (Biomaterial 18, P613-622, 1997) using 50/50 copoly (L-lactide/e-caprolactone) bioabsorbable material, dissolved in 1,4-(11〇31^ and 〇:-116 again & In the solvent of 116(90/10), add saccharose crystals, mix well and then cool the bundle at -15 °C, then remove the solvent by vacuum distillation method, then wash the saccharose crystals with water to form porous Material.

Susan L. Ishaug-Riley et al. (Biomaterial 19, P1405-1412, 1998) used a 75:25 poly(DL-lactic-co-glycolic acid) (PLGA) bioabsorbable polymer using the solvent-casting particulate-leaching method. A porous material is prepared.

Robert C. Thomson et al. (Biomaterial 20, P2007-2018, 1999) used 85:15?〇17(1)1^-13〇1:1〇:-(;〇-运1丫(:〇1化3 (:1〇1)(?1^8) Bioabsorbable polymer, prepared by solvent-casting and salt-leaching methods. 1248950

A method for the preparation of a Porous Bioresorbable Polyesters is disclosed in U.S. Patent 4,702,917. The technical content of this patent is to co-melt the bioabsorbable polymer material of polycaprolactone and po 1 yoxy propy 1 ene under heating, and then cool the formed molten mixture to form a solidified material. This cured material is then stripped of the pol yoxy propy 1 ene using solvent extraction to form a bioabsorbable porous polyester material.

A method of making an implantable porous film is disclosed in U.S. Patent No. 4,199,864. The technical content of this patent is to polymerize a polymer monomer by heating a polymer monomer with a soluble salt particle such as sodium chloride (NaC 1 ). Then, the salt particles are washed with water to prepare a porous film.

A method of preparing polymer membranes having a three dimensional structure is disclosed in U.S. Patent No. 5,514,378. The technical content of this patent is that the polymer is dissolved in a solvent to form a polymer solution, and the salt particles (dip 11: particles) are added to the polymer solution and stirred uniformly, and then poured into a mold. Further, φ of the polymer solution containing the salt particles is heated to remove the solvent to form a polymer film containing the salt particles. The polymer film is then placed in water or other solvent which can dissolve the salt particles. After a suitable time, the salt particles are washed out to obtain a three-dimensional structure prepared by preparing a three-dimensional structure. SUMMARY OF THE INVENTION It is an object of the present invention to provide a novel method of making a porous material having interconnected pores. 1248950 A method of making a porous material having alternating interconnected pores of the present invention comprises the steps described below. One or more bioresorbable polymers and a low molecular weight polymer ("iigomer") are dissolved in an organic solvent to form a bioabsorbable polymer solution. The molecular weight of the polymer is between 200 and 10,000. Then, the bioabsorbable polymer solution is formed into a preform. Then, drying is carried out to partially or completely remove the organic solvent on the surface of the preform. The preform is then contacted with a coagulant to form a porous material. The low molecular weight polymer is soluble in the coagulating liquid, and the bioabsorbable polymer is insoluble in the coagulating liquid. A first feature of the present invention is that a low-powder polymer is added to the bioabsorbable polymer solution as a pore-forming agent (P〇re f 〇rmer). During the solidification of the bioabsorbable polymer solution, the low molecular weight oligopolymer diffuses into the coagulating liquid at a slower rate, and the bioabsorbable polymer forms a porous material having interconnected pores. A second feature of the present invention is that after the preform is formed, it is dried before being brought into contact with the coagulating liquid. In this way, the surface of the preform can be solidified, ensuring a more fixed shape of the preform, and having better film forming properties, so that the preform does not spread out in the coagulating liquid when placed in the coagulating liquid. . Φ A third feature of the present invention is that two or more kinds of bioabsorbable polymers having different decomposing speeds can be used. Thus, the purpose of controlling the degradation rate of the resulting porous material can be achieved by adjusting the ratio of different bioabsorbable ruthenium molecules. [Embodiment] The present invention provides a novel method for preparing a material having alternating interconnected holes. The method consists of firstly dissolving one or more bioresorbable p〇iymer and a low molecular weight oligo 1284950 (oligomer) in an organic solvent to form a bioabsorbable polymer. Solution. Then, the bioabsorbable polymer solution is applied to a surface of a mold or poured into a container to form the bioabsorbable polymer solution into a preform having a fixed shape, for example, forming a thickness of about 0. · Films from 1 mm to 5 mm. Then, drying is carried out to partially or completely remove the organic solvent on the surface of the preform. For example, a flat mold having a surface covering the bioabsorbable preform or a container containing the bioabsorbable preform is allowed to stand in the air for about 5 minutes to partially evaporate the solvent on the surface and solidify the preform. Then, a flat mold covering the bioabsorbable preform or a container containing the bioabsorbable preform is placed in a coagulant to contact the coagulating liquid to form a porous polymer material. The preform is preferably contacted with the coagulating liquid at a temperature of from 5 ° C to 60 ° C, more preferably at a temperature of from 10 ° C to 50 ° C in contact with the coagulating liquid. The material of the mold or container used above is not particularly limited and may be high molecular weight, inorganic ceramic, or metal. The present invention uses one or more bioabsorbable polymer materials, and the bioabsorbable polymer used may have a molecular weight of 20,000 or more, preferably between 20,000 and 1,500,000. The molecular weight of the low molecular weight oligo polymer is between 00 and 10,000, preferably between 200 and 5,000. According to the present invention, the bioabsorbable polymer suitable for use may be PCL (polycaprolactone; polycaprolactone), PLA (polylactic acid; polylactic acid), PLLA [(Poly-L-lactide); poly-L-lactic-lactic acid], PGA (polyglycol ic acid; polyglycolic acid), PLGA copolymer (poly-lactic-co-glycolic acid copolymer), PCL-PLA copolymer (polycaprolactone-polylactic acid copolymer) Polycaprolactone- 11 1248950 polylactic acid copolymer), PCL-PEG copolymer (polycapro lac tone-polyethylene glycol copolymer; polycaprolactone-polyethylene glycol copolymer), or a mixture thereof. Suitable low molecular weight oligopolymers may be bioabsorbable or non-bioabsorbable, and may be PCLTL (polycaprolactone triol; polycaprolactone triol) having a molecular weight of less than 10,000, PCLDL (polycaprolactone diol; polycaprolactone diol) , PCL (polycaprolactone), polylactic acid, PEG (polyethylene glycol), PPG (polypropylene glycol mixture. According to the present invention, the above organic solvent for dissolving the bioabsorbable polymer and the low molecular weight oligopolymer may be N,N-dimethy 1 formamide (DMF; N,N-dimercaptocarbamide), N,N- Dimethyl acetamide (DMAcN, N-dimethylacetamide), Tetr ahydro fur an (THF; tetrahydrofurfuran), alcohols, Chloroform (chloroform), Dichloromethane (DCM; dimethyl carbamide), 1, 4 -dioxane (1,4-dioxane), or a mixture thereof. The bioabsorbable polymer in the bioabsorbable solution may have a weight fraction of from 5 to 70%, preferably from 10 to 50%. The amount of the low molecular weight oligopolymer in the bioabsorbable solution may be from 10 to 80% by weight of the non-solvent portion of the solution. According to the present invention, the coagulating liquid may be water, an organic solvent, a mixed organic solvent, or a mixture of water and an organic solvent. Preferably, the coagulating liquid comprises water and an organic solvent, and the weight fraction of the organic solvent in the coagulating liquid is preferably from 5 to 90%. The organic solvent in the coagulating liquid may be an amide, a ketone, an alcohol, or a mixture thereof. The organic solvent in the coagulating liquid preferably includes ketones and alcohols. Specific examples of the organic solvent in the coagulating liquid include N,N-dimethy1formamide (DMF) j N, N-dimethylacetamide 12 93⁄43⁄4 1248950 (DMAc), Tetrahydrofuran (THF; tetrahydrofuran), acetone (acetone) and methyl ethyl ketone (methyl ethyl ketone). , MEK) and other ketone solvents, or alcohol solvents such as methanol, ethanol, propanol, isopropanol and butanol. In the method of the present invention, the organic solvent used for preparing the bioabsorbable polymer solution is a good solvent for the bioabsorbable polymer. The organic solvent in the bioabsorbable polymer solution exchanges with the polymer insoluble solvent (bad sol vent) in the coagulation liquid, and the polymer material is gradually precipitated, gradually forming a certain foaming ( A substrate that is foaming. This is the so-called phase separation method. In the general case, a material formed only by exchange of a good solvent and a poor solvent, usually has a low porosity and a non-uni form, and exhibits a non-interconnected closed pore (closed). Cell) type. However, in the present invention, the phase separation method is not simply used. According to the first feature of the present invention, a low molecular weight oligomer is added to the bioabsorbable polymer solution. Since the oligopolymer has a certain degree of molecular weight, these low molecular weight oligopolymers diffuse into the coagulating liquid at a slow rate during solidification of the bioabsorbable polymer solution, and can form a porous body with a uniform interactive structure. Sexual material. Therefore, in the present invention, the low molecular weight oligopolymer plays a role as a pore former. The porosity and pore size of the finally formed porous material can be adjusted by selecting the type, molecular weight, and content of the low molecular weight oligopolymer in the solution forming the bioabsorbable polymer. According to the present invention, after the bioabsorbable polymer solution is formed into a preform having a fixed shape, it is dried to partially or completely remove the organic solvent on the surface of the preform. The preform is then brought into contact with the coagulating liquid. The imid liquid im 13 1248950 functions to allow the organic solvent remaining in the bioabsorbable polymer solution and the low molecular weight f polymer to be uniformly and uniformly displaced, and diffused and dissolved in the coagulation liquid. As for the bioabsorbable polymer of a molecular weight, it does not dissolve in the coagulating liquid, but forms a porous material having mutually interconnected pores. The first feature of this month is that after the preform is formed, it is dried before it comes into contact with the coagulating liquid. In this way, the surface of the preform can be cured, 'ensuring that the preform has a more fixed shape and better film forming properties, so that the preform does not spread out in the coagulating liquid when it is placed in the coagulating liquid. . / - The drying method suitable for the present invention is not limited as long as the organic solvent on the surface of the preform can be partially or completely removed. Preferably, the dry <drying causes the preform to form a gel surface or a non-sticky (f), surface. Suitable drying methods are, for example, direct drying in air at room temperature, drying, drying in a drying phase, drying under reduced pressure, radiation drying, and the like. A third feature of the present invention is that two or more bioabsorbable polymers having different degradation rates can be used, and are dissolved in an organic solvent in an appropriate ratio with a low molecular weight polymer, and the above method of the present invention is carried out. A porous material having interconnected pores is obtained. Thus, the rate of degradation of the resulting porous material can be controlled by adjusting the ratio of different bioabsorbable south molecules. After the bioabsorbable polymer solution is brought into contact with the coagulating liquid, it is preferred that the resulting porous material is placed in a washing liquid for washing. The cleaning solution may be water, an organic bath, or a mixture thereof, and the organic solvent may be a ketone, an alcohol, or a mixture thereof. Specific examples of the organic solvent as the cleaning liquid include ketone solvents such as acetonitrile, methyl ethyl ketone (MEK), or methanol, ethanol, and propanol. (pr〇pan〇1), isopropanol 1248950 (isopropanol), butanol (butanol) and other alcohol solvents. In the following, the present invention is intended to illustrate the method, features, and advantages of the present invention, but is not intended to limit the scope of the present invention. Example 1 15 g of a PCL (Polycaprolactone) bioabsorbable polymer material having a molecular weight of about 80,000, and 15 g of a PEG (Polyethylene glycol) having a molecular weight of 1000 were added to 70 g of a THF organic solvent. Stir at room temperature to form a PCL solution containing PEG oligomeric polymer. The solution was then coated onto a flat mold (MoId) having a thickness of about 〇·5 mm. Next, a flat mold having a surface covering the pcl solution was placed in a coagulating liquid at 25 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 1), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed for 2 hours, and finally washed with clean water, and dried to obtain a flat film-like porous PCL material. In order to test whether the flat membrane porous PCL material has an interactive communication pore structure, the flat membrane porous PCL material 1 is covered on a water-filled glass measuring drum 2, and the measuring barrel 2 is sealed, for example, by a fixing rope. 3 Fix the PCL material 1 on the glass measuring drum 2 as shown in Fig. 1A. The glass barrel is then reversed as shown in Figure 1B. After a few seconds, the water in the glass drum gradually penetrates the porous PCL material 1. The water penetration test confirmed that the produced PCL flat film was a material having an interconnected pore structure. Samples #1A, #1B, #1C, #1D were observed by SEM, and it was confirmed that the PCL flat film produced in the present embodiment was a material having an interconnected pore structure. 15 ifxf 1248950 Table 1 Sample No. Coagulating Liquid Type Solidification Time (hours) Porous Substrate Hole Type SEM Photo 1A 40 wt% Acetone 4 Interconnected 2A Figure 1B 40 wt% Ethanol 4 Interactively Connected 2B Figure 1C 60 wt % Ethanol 4 Interactively connected 2C Figure 1D 20 wt% DMF 4 Interactively connected Figure 2D Example 2 Take 15g of PCL polymer material with a molecular weight of about 80,000, and 15g of polymerized PPG (Polypropylene glycol) with a molecular weight of 1000 The solution was uniformly stirred in a 70 g portion of THF organic solvent at room temperature to form a PCL solution. The solution is then applied to the surface of a flat mold having a thickness of about 0.5 mm. Next, a flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 25 ° C (the solidifying liquid composition and solidification forming time are as shown in Table 2), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone and immersed for 2 hours, and finally washed with clean water and dried to obtain a porous PCL material. The flat membrane-like porous PCL material produced in this example was subjected to a water penetration test, and it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 2 Sample No. Coagulating Liquid Type Setting Time (hours) Porous Substrate Hole Type 2A 40 wt% Acetone 3 Interconnected 2B 40 wt% Ethanol 3 Interactively Connected 2C 60 wt% Ethanol 3 Interactively Connected 2D 20 wt% DMF 3 Interacting 16 1248950 Example 3 15 g of PCL polymer material with a molecular weight of about 80,000, and 15 g of PTMG (Poly tetrame thy lene glycol) having a molecular weight of 1000 were added to 70' g of THF organic solvent at room temperature. The conditions were stirred to form a PCL solution. The solution was applied to the surface of a flat mold, and the thickness of the coating was about 〇5 mm. Then, a flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 25 ° C (the composition of the condensate and the solidification forming time are as shown in Table 3), and solidified to form a porous PCL material. Then, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed and washed for 2 hours, and finally cleaned with a clean water | washed and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 3 Sample No. Coagulating Liquid Type Solidification Time (hours) Porous Substrate Hole Type 3A 40 wt% Acetone 2 Interconnected 3B 40 wt% Ethanol 2 Interactively Connected 3C 60 wt% Ethanol 2 Interactively Connected 3D 20 wt°/〇 DMF 2 interactive connection

Example 4 15 g of a PCL polymer material having a molecular weight of about 80,000, and 15 g of an oligomeric polymer having a molecular weight of 300, PCLTL (Polycaprolactone triol), were added to 70 g of an organic solvent of THF, and stirred at room temperature to form a PCL solution. The solution is then applied to the surface of a flat mold having a thickness of about 0.5 mm. Next, a flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 25 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 4), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, soaked for 17 hours, washed for 2 hours, and finally washed with clean water, and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interactive communication hole structure. Table 4 Sample No. Coagulating Liquid Type Setting Time (hours) Porous Substrate Hole Type 4A 40 wt% Acetone 4 Interconnected 4B 40 wt% Ethanol 4 Interconnected 4C 60 wt% Ethanol 4 Interactively Connected 4D 20 wt% DMF 4 Interactive connection

Example 5 15 g of a PCL polymer material having a molecular weight of about 80,000 and 15 g of a polymer PEG (Polyethyl ene glycol) having a molecular weight of 1000 were added to 70 g of a DMF organic solvent, and stirred at room temperature to form a PCL solution. 5毫米。 The thickness of the coating is about 0. 5mm. Next, a flat mold having a surface covered with a PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 5), and solidified to form a porous PCL material. Subsequently, the porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed for cleaning, and finally washed with clean water and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Samples #5A, #5B, #5C, #5D were observed by SEM, and it was confirmed that the PCL flat film produced in the present embodiment was a material having an interconnected pore structure. Table 5 Sample No. Coagulating Liquid Type Solidification Time (Hour) Porous Ten SEM Photo Hole Type 18 1248950 5Α 40 wt% Acetaie 3 Cross Sittong 3A Figure 5Β 40 wt% Ethanol 3 Pay Money 3B Figure 5C 60 wi % Ethanol 3 3D Figure 5D 20 wt^ JW 3 Crossword 3D Figure 6 Take 15 grams of PCL polymer material with a molecular weight of about 80,000, and 15 grams of oligopolymer PPG (Polypropylene glycol) It was added to 70 g of DMF organic solvent and stirred at room temperature to form a PCL solution. 5毫米。 The thickness of the coating is about 0. 5mm. Next, a flat mold having a surface covered with a PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 6), and solidified to form a porous PCL material. The porous PCL material to be formed is then placed at 50 wt ° /. Iso soak in Acetone's cleaning solution for 2 hours, then clean it with clean water and dry to obtain porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 6 言^}^Number Coagulating liquid type setting time (hours) Porous ten-hole type 6A 40 wt% Acetaie 2 交钱通6B 40 wt% Ethanol 2 交 Sit通 6C 60 wt% Ethanol 2 交钱通6D 20 Wt% JM 2 交钱通 t Example 7 19 1248950 Take 15g of PCL polymer material with a molecular weight of about 80,000, and 15g of PTMG (Polytetramethylene glycol) with a molecular weight of 1000 added to 70g of DMF organic solvent. Stir at room temperature to form a PCL solution. The solution is then applied to the surface of a flat mold having a thickness of about 0.4 mm. Next, the flat mold which covered the surface and covered with the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the setting time of the solidification are shown in Table 7), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed for 2 hours, and finally washed with clean water, and dried to obtain a porous PCL material. The flat membrane porous PCL material was subjected to water penetration test, and it was confirmed that the produced PCL flat g was a material having an interconnected pore structure. Table 7: Robbery No. Coagulating Liquid _ Coagulating Time (Hour) Multi-L-Based Substrate Hole Type 7A 40 wt% Acetone 4 Traffic 7B 40 wt% Ethanol 4 Traffic 7C 60 wt% Ethanol 4 Newton 7D 20 wt% Example 4: Take 15g of PCL polymer material with a molecular weight of about 80,000, and 15g of polymerized PCLTL (Polycaprolactone triol) with a molecular weight of 300 added to 70g of DMF organic solvent, and mix evenly at room temperature. A PCL solution was formed. 2毫米。 The thickness of the coating is about 0. 2mm. Next, a flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 8), and solidified to form a porous PCL material. Then, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed and washed for 2 hours, and finally washed with clean water, and dried to obtain a porous PCL material.

20 1248950 material. The flat membrane porous PCL material was confirmed by a water penetration test to be a material having an interconnected pore structure. Table 8 Word strategy number Coagulation liquid type Solidification time (hours) Porosity turn · Hole type 8A 40 wt% Acetone 1 Cross Sitton 8B 40 wt% Ethanol 1 Crossing mystery 8C 60 wt% Ethanol 1 Paying money 8D 20 Wt% wins 1 traffic

Example 9 15 g of PCL bioabsorbable polymer material having a molecular weight of about 80,000, and 15 g of a molecular weight of 1250 oligopolymer PCLDL (Polycaprolactone diol) were added to 70 g of DMF organic solvent, and stirred at room temperature to form PCL. Solution. 4毫米。 The thickness of the coating is about 0. 4mm. Next, a flat mold having a surface covered with a PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the condensed liquid and the solidification forming time are as shown in Table 9), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetonj and immersed for 2 hours, and finally washed with clean water and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 9 Words Coding Liquid _ Coagulating Time (Hour) Multi-T-W-Base # Hole Type 9A 40 wt% Acetone 4 Cross-Newton 9B 40 wt% Ethanol 4 Traffic 9C 60 wt% Ethanol 4 Cross-link 21 1248950 9D 20 wt% DMF 4 Transportation example ίο 15 g of PCL polymer material with a molecular weight of about 80,000, and 15 g of a molecular weight PC50L (Polycaprolactone diol) with a molecular weight of 1250· added to 70 g of THF: organic solvent, in the room Stir under temperature conditions to form a PCL solution. 5毫米。 The thickness of the coating is about 0. 5mm. Next, a flat mold having a surface covered with a PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 10), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone and immersed in 0 for 4 hours, and finally washed with clean water and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 10: Package No. Coagulating Solution _ Coagulating Time (Hour) Multi-T-W-Base # Hole Type 10A 40 wt% Acetone 24 Traffic 10B 40 wt% Ethanol 24 Money Link 10C 20 wt% HF 24 Money Delivery Example 11 15 g of PCL polymer material having a molecular weight of about 80,000, and 15 g of PEG (Polyethylene glycol) having a molecular weight of 1250 were added to 70 g of an organic solvent of THF, and stirred at room temperature to form a PCL solution. 4毫米。 The thickness of the coating is about 0. 4mm. Next, a flat mold having a surface covered with a PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 11), and solidified to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone and immersed for 4 22 7 0 ^ 1248950 hours, and finally washed with clean water and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 11 Recording number coagulating liquid _ solidification time (hours) more? W raw base # hole type 11A 40 wt% Ethanol 24 money miscellaneous example 12 take molecular weight of about 80,000 PCL bioabsorbable polymer material 15 grams, 7 A polymer of PCLTL (Polycaprolactone triol) and 8 g of PEG (Poly ye thy lene glycol) having a molecular weight of 300 were added to 55 g of DMF organic solvent to form a PCL solution. 4毫米。 The thickness of the coating is about 0. 4mm. Next, a flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are shown in Table 12) to form a porous PCL material. The formed porous PCL material was then placed in a cleaning solution containing 50 wt% Acetone for 4 hours, and finally washed with clean water and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. ® Table 12 Words Coagulation Solution _ Coagulating Time (Hour) Multi-L-Based Substrate Hole Type 12A 40 wt% Acetone 3 Cross-New Zealand 12B 40 wt% Ethanol 3 Cross Sii Pass 12C 20 wt% IMF 3 Traffic Implementation Example 13 23 1248950 Take 15 g of PCL bioabsorbable polymer material with a molecular weight of about 80,000, 15 g of molecular weight 300 oligopolymer PCLTL (Polycaprolactone triol), add to 35 g of DMF and 35 g of THF organic solvent and stir to form PCL. Solution. : The solution is then applied to the surface of a flat mold having a thickness of about 0.4 mm.揍: A flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 13) to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed for 4 hours, and finally washed with clean water, and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interactive g-pass structure. Table 13 Words 篆 Number Coagulating liquid type Solidification time (hours) Porous singularity Hole type 13A 40 wt% Acetone 4 交钱通 13B 40 wt% Ethanol 4 交通通 13C 20 wt% IMF 4 交钱通 Example 14

15 g of PCL bioabsorbable polymer material with a molecular weight of about 80,000, and 15 g of a polyether polymer PCLTL (Polycaprolactone triol) having a molecular weight of 300 were added to 55 g of DMF and 15 g of Ethanol organic solvent to form a PCL solution. The solution is then applied to the surface of a flat mold having a thickness of about 4 mm. Next, a flat mold having a surface covered with the PCL solution was placed in a coagulating liquid at 20 ° C (the solid solution composition and solidification forming time are as shown in Table 14) to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed for 4 hours, and finally washed with clean water, and dried to obtain a porous 1248950 PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material having an interconnected pore structure. Table 14 Although the number of the coagulation liquid _ solidification time (hours) more iW Shengji # hole type 14A 40 M Acetone 4 pay money 14B 40 wt% Ethanol 4 pay money 1C 20 wt% DMF 4

Example 15 15 g of PCL material having a molecular weight of about 80,000 and 10 g of a polymer having a molecular weight of 300 were added. PCLTL (Polycaprolactone triol) was added to 75 g of THF in an organic solvent to form a PCL solution, No. 15A. 15 g of PCL material having a molecular weight of about 80,000, and 20 g of polymerized PCLTL having a molecular weight of 300 were added to 65 g of THF organic solvent to form a PCL solution, No. 15B. 15 g of PCL material having a molecular weight of about 80,000, and 30 g of an oligomeric polymer PCLTL having a molecular weight of 300 were added to 45 g of an organic solvent of THF to form a PCL solution, No. 15C. Each PCL solution was applied to the surface of a flat mold, and the thickness of the coating was about 3 mm. Next, a flat mold having a surface covered with the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 15) to form a porous PCL material. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone, immersed for 4 hours, and finally washed with clean water, and dried to obtain a porous PCL material. The above-mentioned No. 15A, 15B, 15C porous PCL material was confirmed by a water penetration test to confirm that the produced PCL flat film was a material having an interconnected pore structure. Sample #15B, #15C was observed by SEM, and it was confirmed that the PCL flat film produced in the present example was a material having an interconnected pore structure. 1248950 Table 15 Sample number coagulating liquid _ Solidification time (hours) Multi-substrate pore type SEM 15A 40 wt% Acetcxie 12 Cross Sittong - 15B 40 wt% Acetaie 12 Cross Sittong 4A Figure 15C 40 wt% Acetaie 12 Qiantong 4B Figure 16 Take 15 grams of PCL material with a molecular weight of about 80,000, and 30 grams of molecular weight 300. Polymer PCLTL (Polycaprolactone triol) is added to 45 grams of DMF organic solvent and stirred to form a PCL solution. The PCL solution was applied to the surface of a flat mold to a thickness of about 2 mm. Next, a flat mold having a surface covering the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are shown in Table 16) to form a porous PCL material of Nos. 16A, 16B, and 16C. The formed porous PCL material was then placed in a cleaning solution containing 50 wt% Acetone for 4 hours, and finally washed with clean water and dried to obtain a porous PCL material. The above-mentioned No. 16A, 16B, and 16C porous PCL materials were subjected to a water penetration test to confirm that the PCL flat film was a material having an interconnected pore structure. ® Table 16 Words 篆 Number Coagulating liquid type Solidification time (hours) Porous Shishengji # Hole type 16A 40 wt% Acetone 6 Cross-link 16B 40 wt% Ethanol 6 交通通16C 20 wt% HF 6 Cross-link Example 17 26 1248950 15 g of PCL material having a molecular weight of about 80,000, and 30 g of an oligomeric polymer PCLTL (Polycaprolactone triol) having a molecular weight of 300 were added to 45 g of THF organic solvent and stirred to form a PCL solution. The PCL solution was applied to the surface of a flat mold 1 to a thickness of about 2 mm. Next, a flat plate-shaped mold having a surface covering the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are shown in Table 17) to form a porous PCL material No. 17A, 17B, 17C. Subsequently, the formed porous PCL material was placed in a cleaning solution containing 50 wt% Acetone for 4 hours, and finally washed with clean water and dried to obtain a porous PCL material. The above-mentioned No. 17A, 17B, and 17C porous PCL materials were subjected to a water penetration test to confirm that the produced PCL% film was a material having an interconnected pore structure. Table 17 Word Policy Number Coagulating Liquid Type Solidification Time (Hour) Porous Ten Health ^# Hole Type 17A 40 wt% Acetone 6 Money Pass 17B 40 wt% Ethanol 6 Traffic 17C 20 wt% IMF 6

Example 18 A PCLTL (Polycaprolactone triol) having a molecular weight of about 30,000 PCL bioabsorbable polymer material and 15 g of a molecular weight 300 oligopolymer was added, and stirred in a 55 g DMF organic solvent to form a PCL solution. The solution is then applied to the surface of a flat mold having a thickness of about 2 mm. Next, a flat mold having a surface covered with the PCL solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 14) to form a porous PCL material. The formed porous PCL material was then placed in a cleaning solution containing 50 wt% Acetone for 4 hours, and finally washed with clean water and dried to obtain a porous PCL material. Through the water penetration test, it was confirmed that the produced PCL flat film was a material with an interconnecting pore structure of 27 974 1248950. Table 18 Following number coagulating liquid _ solidification time (hours) porous substrate pore type 18A 40 wt% Acetone 8 pay money 18B 40 wt% Ethanol 8 cross puzzle 18C 20 wt% DMF 8 cross puzzle 75/25 Biosorbable polymer material of PCL-PLA copolymer (Polycaprolactone-Polylactic acid copolymer) 30g, and 15g

Example 19 A polymer of PCLTL (Polycaproiact〇ne triol) was placed in a mixture of 55 g of THF organic solvent to form a pCL-PLA solution. Subsequently, the PCL-PLA solution was applied to the surface of a flat mold, and the thickness of the coating was about 0.4 mm. Next, a flat mold having a surface covered with a PCL-PLA solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 19) to form a porous PCL-PLA material. The formed porous PCL material was then placed in a cleaning solution containing 50 wt% Acetone for 4 hours, and finally washed with clean water and dried to obtain a porous _PCL-PLA material. Through the water penetration test, it was confirmed that the produced PCL-PLA flat film was a material having an interactive communication hole structure. Table 19 Sample number Coagulating liquid type Solidification time (hours) Polyterpene base #孔洞型19A 40 wt% Acetone 12 交钱通19B 40 wt% Ethanol 12 交Sii通 19C 20 wf/〇DMF 12 Traffic 28 1248950 Implementation Example 20: 10 g of PLA bioabsorbable polymer material having a molecular weight of about 1 million, and 5 g of an oligomeric polymer 'PCLTL (Polycaprolactone triol) having a molecular weight of 300, added to an organic solvent of 85 g of a gas-burning organic solvent Stir well to form a PLA solution. The PLA solution was then applied to the surface of a flat mold to a thickness of about 3 mm. Then, the flat-plate-shaped mold covered with PLA was allowed to stand in air at 25 ± 2 ° C for 5 minutes to volatilize the solvent on the surface, and then the flat mold covering the PLA solution was placed in a coagulating solution at 20 ° C. (The composition of the coagulating liquid and the solidification forming time are as shown in Table 20) to form a porous PLA material. The porous PLA material formed was placed in a cleaning solution containing 50 wt% Acetone and immersed for 4 hours, and finally washed with clean water and dried to obtain a porous PLA material. Through the water penetration test, it was confirmed that the produced PLA flat film was a material having an interconnected pore structure. Table 20 Words 篆 Number Coagulating liquid type Solidification time (hours) Multi-L property: 3⁄4 material hole type 20A 40 wt% Acetone 12 交钱通20B 40 wt% Ethanol 12 交钱通20C 20 wt% EMF 12 交 Sit Example 21 15 g of a PLGA bioabsorbable polymer material and 15 g of a molecular weight of 300 oligopolymer PCLTL (Polycaprolactone triol) were added and stirred in a 70 g THF organic solvent to form a PLGA solution. The PLGA solution was then applied to the surface of a flat mold having a thickness of about 2 mm. Next, a flat mold having a surface covering the PLGA solution was placed in a coagulating liquid at 20 ° C (the composition of the coagulating liquid and the solidification forming time are as shown in Table 21) to form a porous PLGA material. The resulting porous material 29 1248950 PLGA material was placed in a cleaning solution containing 50 wt% Acetone and immersed for 4 hours, and finally washed with clean water and dried to obtain a porous PLGA material. Through the water penetration test, it is confirmed that the prepared PLGA flat film is a kind of material with interactive communication pore structure number Coagulating liquid type solidification time (hour) Porous substrate pore type 21A 40 wt% Acetone 12 Jiaotongtong 21B 40 wt% Ethanol 12 Pay Money 21C 20 wt% EMF 12

Example 22

A molecular weight (Molecular weight) of about 80,000 pcL (Polycaprolactone) and a molecular weight of about 500,000 (p〇ly lactide) two kinds of bioabsorbable high-substance materials 'PCL and pla are mixed with each other to form a poly blend in different ratios ( After Polymer Blend), it was dissolved in a two-gas calcination (pCL-PLA mixing ratio is shown in Table 22), and then a low molecular weight oligo polymer PEG (Polyethylene glycol) was added, and the molecular weight was about a blend solution. 300, evenly formed after stirring

Then, the solution is coated on the surface of a flat mold (Mold), the thickness of the coating is about 2 mm, and then the flat mold covering the surface of the PCL and the PLA solution is allowed to stand in the air at 25 ± 2 ° C. Dry to volatilize the solvent on the surface. Refer to the ASTM C697-87 (1997) standard test method for Tack Free time test, and perform the Tack f ree ti me test on the surface of the blend solution. The test results are as follows. Table 23 shows. 30 1248950 Table 22

Table 23

31 1248950 Example 2 3 Two kinds of bioabsorbable high-substance materials with a molecular weight of about 80,000 PCL (Polycaprolactone) and a molecular weight of about 500,000 (Poly lactide), which are mixed with PCL and PLA in different proportions - After polymerizing the blend, it is dissolved in di-methane, (the mixing ratio of PCL to PLA is shown in Table 24), and then the low molecular weight oligo PEG (Polyethylene glycol) is added, and the molecular weight is about 300. A homogeneous mixed solution is formed. Subsequently, the solution was applied to the surface of a flat mold, and the thickness of the coating was about 3 mm, and then the flat mold of the surface covering the PCL and the PLA solution was applied at 25 ± 2 φ ° C under different curing conditions (surface curing conditions). As shown in Table 25, the solvent of the surface was volatilized and solidified. Next, it was placed in a 40 wt% Acetone coagulating solution at 20 ° C for a solidification time of 4 hours to solidify to form a porous material.

Finally, the formed porous material was placed in a cleaning solution containing 50 wt% Acetone and immersed for 4 hours, and then washed and washed with clean water to obtain a flat membrane-like porous PCL/PLA (Polymer Blend) material. Through the water penetration test, it was confirmed that the produced PCL/PLA flat film was a material having an interconnecting via structure. Sample #23A is a sample that has not undergone a surface curing procedure and cannot be solidified into a film, as shown in Fig. 5A. Samples #23B, #23C, #23D, #23E were surface-cured and observed by SEM. As shown in Figures 5B and 5C, it was confirmed that the PCL/PLA mixed film produced in this example was The material that interacts with the pore structure. 32 1248950

Table 25 PCL, PLA / oligomer / solvent 15 / 15 / 70 Result surface cure time (min) SEM photo sample number 0 5A Figure 23A 2 - 23B 5 5B Figure 23C 10 - 23D 15 (solvent completely removed 5C Figure 23E Example 24

Take PCL (Polycaprolactone) with a molecular weight of about 80,000 and PLA (Poly lactide) with two molecular weights of about 500,000. Biolsorbable polymers are mixed with PCL and 33 1248950 PLA in different proportions. After polymer blending (Polymer Blend), it is dissolved in di-methane, (PCL and PLA mixing ratio is shown in Table 26), and then low molecular weight polymer PEG (Polyethylene glycol) is added, and the molecular weight is about 300. After stirring, a homogeneous mixed solution is formed. · The solution is applied to the surface of a flat mold, and the thickness of the coating is about 3 mm. Then, the flat mold covering the PCL and PLA solution is allowed to stand in air at 30 ± 2 ° C for about 5 minutes to make the surface. The solvent evaporates and solidifies. Next, it was placed in a 40 wt% Acetone coagulating solution at 20 ° C for a solidification time of 4 hours to solidify to form a porous material. φ Finally, the formed porous material was placed in a cleaning solution containing 50 wt% Acetone and immersed for 4 hours, and then washed and dried with clean water to obtain a flat membrane-like porous PCL/PLA mixed (Polymer Blend) material. Through the water penetration test, it was confirmed that the produced PCL/PLA flat film was a material having an interconnecting via structure. Samples #24A, #24D, #24E were observed by SEM as shown in Fig. 6A, Fig. 6B and Fig. 6C, and it was confirmed that the PCL/PLA mixed film produced in the present example was an interconnected pore structure. Material.

34 1248950 Table 26

PCL, PLA / Concentrate / Solvent 15 / 15 / 70 Ingredients Mixing Ratio 彳 PCL PLA PEG300 Dichlorometha ne SEM Photo No. 90/10 13.5% 1.5% 15% 70% Figure 6A Figure 24A 80/20 12% 3% 15% 70% — 24B 70/30 10. 5% 4. 5% 15% 70% - 24C 60/40 9°/〇6% 15% 70% Figure 6B Figure 24D 50/50 7. 5°/〇4 . 5°/〇15% 70% Figure 6C Figure 24E

Example 25 A molecular weight (Molecular weight) of about 80,000 PCL (Polycaprolactone) and a molecular weight of about 150,000 PLGA (poly-lactic-co-glycolic acid) two bioabsorbable high-substance materials, PCL and PLGA After mixing into a poly blend in different proportions, it is dissolved in dioxane (the mixing ratio of PCL to PLGA is shown in Table 27), and then the molecular weight of PEG (Polyethylene glycol) is about 300. After stirring, a homogeneous mixed solution is formed. Then, the solution is applied to the surface of a flat mold, and the thickness of the coating is about 3 mm. Then, the flat mold covering the surface of the PCL and the PLGA solution is allowed to stand in the air at 15±2 ° C for about 5 minutes to make the surface. The solvent evaporates and solidifies. Next, it was placed in a 40 wt% Acetone coagulating solution at 20 ° C for a solidification time of 4 hours to solidify to form a porous material. Finally, the formed porous material was placed in a cleaning solution containing 50 wt% Acetone and immersed for 4 hours, and then washed and washed with clean water to obtain a flat membrane-like porous PCL/PLGA hybrid (Polymer Blend) material. Through the water penetration test, it was confirmed that the produced PCL/PLGA flat film was a material having an interconnecting via structure. Sample #25A was observed by SEM, and as shown in Fig. 7, it was confirmed that the PCL/PLGA mixed film produced in the present embodiment was a material having an interconnected pore structure. Table 27

PCL, PLGA / Polymer/Solvent 15 / 15 / 70 Ingredients PCL PLGA PEG300 Dioxethane SEM Photo Sample Mixing Ratio No. 70/30 10.5% 4. 5% 15% 70% Figure 7 25A 50/50 7 5% 4. 5% 15% 70°/〇一25B

While the present invention has been described in its preferred embodiments, the present invention is not intended to limit the invention, and the invention may be modified and retouched without departing from the spirit and scope of the invention. The scope of protection is subject to the definition of the scope of the patent application attached. 36 1248950 BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1A is a view showing a water penetrating test of an embodiment of the present invention, in which the glass measuring cylinder is upright. Fig. 1B is a view showing the water penetration test of the embodiment of the present invention, in which the glass cylinder is inverted. 2A to 2D are SEM photographs showing the porous PCL material obtained in Example 1 of the present invention, in which the magnification of the 2A to 2C graph is 2000X, and the magnification of the 2D graph is 1500X. 3A to 3D are SEM photographs showing the porous PCL material obtained in Example 5 of the present invention, wherein the magnification of the 3A drawing is 5000X, the magnification of the 3B drawing is 1500X, and the magnification of the 3C drawing is 2000X, and the 3D figure is 3D. The magnification is 1500X. 4A and 4B are SEM photographs of the porous PCL material obtained in Example 15 of the present invention, the magnification of Fig. 4A is 350X, and the magnification of Fig. 4B is 500X. 5A to 5C are SEM photographs of the porous PCL/PLA mixed material obtained in Example 23 of the present invention, and FIG. 5A is a photograph which cannot be solidified in the coagulating liquid without the surface curing treatment procedure, and the magnification of the 5B graph is shown in FIG. 800X, the magnification of the 5C figure is 1200X. 6A to 6C are photographs showing the SEM photograph of the porous PCL/PLA mixed material obtained in Example 24 of the present invention. The magnification of Fig. 6A is 1500X, the magnification of Fig. 6B is 3000X, and the magnification of Fig. 6C is 950X. Fig. 7 is a SEM photograph showing a porous PCL/PLGA mixed material obtained in Example 25 of the present invention, and the magnification of Fig. 7 is 1500X. Symbol Description: None. 37 7 ri

Claims (1)

1248 said y&y number reading; Lizwei repairing shackles, "repaired households called Π Π 缚}} this period: · / • 卜 拾, apply for patent _ 1 · a porous with interactive holes The method for preparing a material comprises the steps of: dissolving one or more bioresorbable polymers and a low molecular weight oligomer in an organic solvent to form a bioabsorbable polymer; a solution, wherein the low molecular weight oligopolymer has a molecular weight of between 200 and 5000; the bioabsorbable polymer solution is formed into a preform and then dried to partially or completely remove the organic solvent on the surface of the preform; And contacting the preform with a coagulant to form the porous material, wherein the low molecular weight oligopolymer is soluble in the coagulating liquid, and the bioabsorbable polymer is insoluble in the coagulating liquid. 2. The method for preparing a porous material having interconnected pores as described in claim 1, wherein the bioabsorbable polymer mixed solution is formed into a preform The method includes the step of applying the solution to a surface of a mold. 3. The method for preparing a porous material having interconnected pores according to claim 1, wherein the bioabsorbable polymer mixed solution is formed into a preform. The step of pouring the solution into a container. 4. The method for preparing a porous material having interconnected pores according to claim 1, wherein the drying step forms the preform into a gel form ( a surface or a tack-free surface. 5. A method of preparing a porous material having interconnected pores as described in claim 1, wherein the drying step is air at room temperature Drying naturally, heating and drying, drying in an oven, drying under reduced pressure, or radiant drying. 6. The method for preparing a porous material having alternating pores as described in claim 1, wherein the biological absorption The molecular weight of the polymer is between 20,000 and 1,500,000. 0648-9954TWF1(N1); 139200003; hsuhuche 38 1248950 7. As described in claim 1 A method for preparing a porous material having mutually interconnected pores, wherein the bioabsorbable polymer is PCL (polycaprolactone; polycaprolactone), PLA (polylactic acid; polylactic acid), PLLA [(Poly-L-lactide); - L-lactic acid], PGA (polyglycolic acid), PLGA (poly-lactic-co-glycolic acid copolymer), PCL-PLA copolymer (polycaprolactone-polylactic acid copolymer; polycaprolactone-polylactic acid copolymer), PCL-PEG copolymer (polycaprolactone_polyethylene glycol copolymer; polycaprolactone-polyethylene glycol copolymer), or a mixture thereof. 8. A method of producing a porous material having mutually interconnected pores as described in claim 1, wherein the bioabsorbable polymer is a mixture of PCL and PLA. 9. A method of producing a porous material having interconnected pores as described in claim 1, wherein the bioabsorbable polymer is a mixture of PCL and PLGA. 10. The method for preparing a porous material having mutually interconnected pores according to claim 1, wherein the low molecular weight oligopolymer is PCLTL (polycaprolactone triol; polycaprolactone triol), PCLDL (polycaprolactone diol) ; polycaprolactone), PCL (polycaprolactone; polycaprolactone), PLA (polylactic acid), PEG (polyethylene glycol; polyethylene glycol), PPG (polypropylene glycol; polypropylene glycol), PTMG (polytetramethylene glycol; Polytetramethylene glycol), or a mixture thereof. 11. The method for preparing a porous material having interconnected pores according to claim 1, wherein the organic solvent for dissolving the bioabsorbable polymer and the low molecular weight oligopolymer is N,N-dimethylformamide ( DMF; Ν,Ν·dimercaptocarboxamide), N,N-dimethylacetamide (DMAcN, N-dimethyl 0648-9954TWF1 (N1 ); 139200003; hsuhuche 39 1248950 acetam), Tetrahydrofuran (THF; tetrahydrogen)咲 )), alcohol, Chloroform (chloroform), Dichloromethane (DCM; methylene chloride), l, 4-dioxane (1,4-dioxane), or a mixture thereof. 12. The method for preparing a porous material having mutually interconnected pores according to claim 1, wherein the bioabsorbable polymer in the solution has a weight fraction of 5-70% 〇13 The method for preparing a porous material having mutually connected pores according to claim 12, wherein the bioabsorbable polymer in the solution has a weight fraction of 10-50%. 14. The method for preparing a porous material having interconnected pores according to claim 1, wherein the amount of the low molecular weight oligopolymer in the solution is 10% of the non-solvent portion of the solution. 80%. 15. A method of producing a porous material having interconnected pores as described in claim 1, wherein the coagulating liquid is water, an organic solvent or a mixture thereof. 16. The method for preparing a porous material having mutually interconnected pores according to claim 15, wherein when the coagulating liquid is a mixture of water and an organic solvent, wherein the weight fraction of the organic solvent is 5- 90%. 17. The method for preparing a porous material having mutually interconnected pores according to claim 16, wherein the organic solvent in the coagulating liquid is selected from the group consisting of amides, ketones, alcohols, and In the group consisting of the mixture. 18. A method of producing a porous material having mutually interconnected pores as described in claim 17, wherein the organic solvent in the coagulating liquid comprises ketones and alcohols. 19. A method of producing a porous material having interconnected pores as described in claim 1, wherein the preform is contacted with the coagulating liquid at a temperature of 5 ° C to 60 ° C. 0648-9954 TWF1 (N1); 139200003; hsuhuche 40 1248950 20. A method of preparing a porous twin material having interconnected pores as described in claim 5, wherein the preform is at a temperature of 10 ° C to 50 ° C Contact with the coagulating liquid at °C. The method for preparing a porous material having interconnected pores as described in claim 1, wherein after the preform is brought into contact with the coagulating liquid, the step of cleaning is: placing the porous material Person - cleaning in the cleaning solution. The preparation method of the dangerous material, wherein the cleaning product, the 嗲 right 擤, the 々 ^ dry h month / the first liquid is water, an organic solvent or a mixture thereof. The organic bath is a ketone, an alcohol, or a mixture thereof. 0648-9954TWF1 (N1); 139200003; hsuhuch 丨 41