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TW350838B - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
TW350838B
TW350838B TW084102060A TW84102060A TW350838B TW 350838 B TW350838 B TW 350838B TW 084102060 A TW084102060 A TW 084102060A TW 84102060 A TW84102060 A TW 84102060A TW 350838 B TW350838 B TW 350838B
Authority
TW
Taiwan
Prior art keywords
alkyl
alkoxy
hydrogen
heterocyclic group
quinoline derivatives
Prior art date
Application number
TW084102060A
Other languages
Chinese (zh)
Inventor
Masaaki Matsuo
Kiyoshi Tsuji
Glen W Spears
Takashi Ogino
Hiroaki Nishimura
Takashi Tojo
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of TW350838B publication Critical patent/TW350838B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A compound of the formula (I): wherein R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, mono (or di or tri) halo C1-6 alkoxy or heterocyclic group, R2 is hydroxy, R3 is C1-6 alkyl, -N (ring) is (II) (in which R4 is C1-6 alkyl, C2-6 alkenyl, alkoxy C1-6 alkyl, cycloC3-6 alkyl or C1-6 alkoxy C1-6 alkoxy C1-6 alkyl and R5 is aryl which may have suitable substituent(s) or heterocyclic group) or N-containing heterocyclic group, R7 is hydrogen or halogen, R8 is hydrogen or C1-6 alkyl or R3 and R8 are linked together to form a bivalent radical of the formula (III), and Z is O or S, and a pharmaceutically acceptable salt thereof.
TW084102060A 1994-03-07 1995-03-04 Quinoline derivatives TW350838B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9404378A GB9404378D0 (en) 1994-03-07 1994-03-07 Quinoline derivatives

Publications (1)

Publication Number Publication Date
TW350838B true TW350838B (en) 1999-01-21

Family

ID=10751426

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084102060A TW350838B (en) 1994-03-07 1995-03-04 Quinoline derivatives

Country Status (6)

Country Link
JP (1) JPH09509957A (en)
AU (1) AU1823595A (en)
CA (1) CA2214521A1 (en)
GB (1) GB9404378D0 (en)
TW (1) TW350838B (en)
WO (1) WO1995024395A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9815178A (en) * 1997-12-15 2000-10-10 Fujisawa Pharmaceutical Co Autoimmunosuppressive and / or enhancer mediated by the increase of nkt cells, compound and process for their production
US6133285A (en) 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
US6121287A (en) * 1998-07-15 2000-09-19 Active Biotech Ab Quinoline derivatives
SE9802550D0 (en) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
SE9802549D0 (en) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
CN100390148C (en) 1999-10-25 2008-05-28 活跃生物技术有限公司 Drugs Used to Treat Malignancies
RU2240313C2 (en) * 1999-10-25 2004-11-20 Эктив Байотек Аб Medicinal agents for treatment of malignant tumors
SE0002320D0 (en) * 1999-10-25 2000-06-21 Active Biotech Ab Malignant tumors
JP2007191495A (en) * 2001-10-22 2007-08-02 Santen Pharmaceut Co Ltd Pruritus treating agent
TWI250023B (en) * 2001-10-22 2006-03-01 Santen Pharmaceutical Co Ltd Pharmaceutical composition for itch treating agent
AUPS058102A0 (en) 2002-02-15 2002-03-14 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
SE8902076D0 (en) * 1989-06-09 1989-06-09 Pharmacia Ab DERIVATIVES OF QUINOLINE-3-CARBOXANILIDE
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
TW222276B (en) * 1992-01-27 1994-04-11 Fujisawa Pharmaceutical Co
GB9311562D0 (en) * 1993-06-04 1993-07-21 Fujisawa Pharmaceutical Co Heterocyclic derivatives

Also Published As

Publication number Publication date
AU1823595A (en) 1995-09-25
WO1995024395A1 (en) 1995-09-14
GB9404378D0 (en) 1994-04-20
CA2214521A1 (en) 1995-09-14
JPH09509957A (en) 1997-10-07

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