TW258735B - - Google Patents
Info
- Publication number
- TW258735B TW258735B TW082106610A TW82106610A TW258735B TW 258735 B TW258735 B TW 258735B TW 082106610 A TW082106610 A TW 082106610A TW 82106610 A TW82106610 A TW 82106610A TW 258735 B TW258735 B TW 258735B
- Authority
- TW
- Taiwan
- Prior art keywords
- represent
- lower haloalkyl
- hydrogen
- benzopyran
- epilepsy
- Prior art date
Links
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000005130 benzoxazines Chemical class 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21797592 | 1992-08-17 | ||
| JP8846293 | 1993-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW258735B true TW258735B (zh) | 1995-10-01 |
Family
ID=26429828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW082106610A TW258735B (zh) | 1992-08-17 | 1993-08-17 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5614633A (zh) |
| EP (1) | EP0655448B1 (zh) |
| KR (1) | KR100231634B1 (zh) |
| CN (1) | CN1044605C (zh) |
| AT (1) | ATE191716T1 (zh) |
| AU (1) | AU4761693A (zh) |
| CA (1) | CA2142471A1 (zh) |
| DE (1) | DE69328366T2 (zh) |
| ES (1) | ES2145129T3 (zh) |
| TW (1) | TW258735B (zh) |
| WO (1) | WO1994004521A1 (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9309716D0 (en) * | 1993-05-12 | 1993-06-23 | Zeneca Ltd | Heterocyclic derivatives |
| JP2649610B2 (ja) * | 1993-11-10 | 1997-09-03 | 日本たばこ産業株式会社 | クロマン誘導体及びその医薬用途 |
| NZ329200A (en) * | 1996-12-16 | 1999-05-28 | Hoechst Ag | Sulphonamide substituted quinazoline, isoquinoline, quinoline or benzo[1,3-]oxazine derivatives and medicaments |
| TW533073B (en) * | 1997-03-03 | 2003-05-21 | Chugai Pharmaceutical Co Ltd | Therapeutic agents for peripheral vascular disease |
| US7161001B2 (en) * | 2000-05-23 | 2007-01-09 | Syngenta Crop Protection, Inc. | Method for making acylamides by synthesizing and acylating benzoxazines |
| WO2001090088A1 (en) * | 2000-05-23 | 2001-11-29 | Syngenta Participations Ag | Method for making acylamides by synthesizing and acylating benzoxazines |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| NZ550441A (en) * | 2004-05-05 | 2009-07-31 | Hoffmann La Roche | Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both |
| WO2006002470A1 (en) * | 2004-06-30 | 2006-01-12 | Monash University | Chiral ligands for asymmetric catalysis |
| KR100889185B1 (ko) * | 2004-12-21 | 2009-03-16 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도 |
| BRPI0515835A (pt) * | 2004-12-21 | 2008-08-12 | Hoffmann La Roche | derivados de tetralina e de indano e seus usos |
| DK1831159T3 (da) * | 2004-12-21 | 2010-03-22 | Hoffmann La Roche | Tetralin og indanderivater samt anvendelser deraf |
| BRPI0515830A (pt) | 2004-12-21 | 2008-08-05 | F Hoffmann La Roche | derivados de cromano e usos dos mesmos no tratamento de distúrbios do sistema nervoso central |
| AU2005318596B2 (en) * | 2004-12-21 | 2010-12-23 | F. Hoffmann-La Roche Ag | Chroman derivatives and their use as 5-HT receptor ligands |
| CA2620846A1 (en) | 2005-09-01 | 2007-03-08 | Janssen Pharmaceutica N.V. | Benzopyran and pyranopyridine derivatives as potassium channel openers |
| ATE499355T1 (de) * | 2005-11-03 | 2011-03-15 | Hoffmann La Roche | Arylsulfonylchromane als 5-ht6-inhibitoren |
| CA2653758A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| KR101064001B1 (ko) * | 2006-06-20 | 2011-09-08 | 에프. 호프만-라 로슈 아게 | 아릴설폰아미딜 테트랄린 유도체 및 이의 용도 |
| WO2007147763A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046300A (en) * | 1960-10-21 | 1962-07-24 | Merck & Co Inc | alpha-trifluoromethyloxyphenylalanines |
| CH674984A5 (zh) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
| IL86798A (en) * | 1987-06-23 | 1992-12-01 | Sanofi Sa | 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them |
| US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
| IL88035A0 (en) * | 1987-10-27 | 1989-06-30 | American Home Prod | Benzopyran derivatives,their preparation and pharmaceutical compositions containing them |
| US5021432A (en) * | 1988-04-26 | 1991-06-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzopyran compound and its pharmaceutical use |
| DE68921972T2 (de) * | 1988-12-13 | 1995-11-16 | Beecham Group Plc | Benzopyran und verwandte Verbindungen. |
| FR2657872B2 (fr) * | 1989-11-06 | 1992-06-12 | Sanofi Sa | Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant. |
| DE4018552A1 (de) * | 1990-06-09 | 1991-12-12 | Sandoz Ag | Asthma-prophylaktische verwendung von k(pfeil hoch)+(pfeil hoch) kanal-activatoren |
| CN1060467A (zh) * | 1990-09-25 | 1992-04-22 | 武田药品工业株式会社 | 1，3-苯并嗪衍生物、其生产方法和用途 |
-
1993
- 1993-08-17 DE DE69328366T patent/DE69328366T2/de not_active Expired - Fee Related
- 1993-08-17 CN CN93109297A patent/CN1044605C/zh not_active Expired - Fee Related
- 1993-08-17 EP EP94908117A patent/EP0655448B1/en not_active Expired - Lifetime
- 1993-08-17 WO PCT/JP1993/001150 patent/WO1994004521A1/ja not_active Ceased
- 1993-08-17 CA CA002142471A patent/CA2142471A1/en not_active Abandoned
- 1993-08-17 TW TW082106610A patent/TW258735B/zh active
- 1993-08-17 AU AU47616/93A patent/AU4761693A/en not_active Abandoned
- 1993-08-17 KR KR1019950700620A patent/KR100231634B1/ko not_active Expired - Fee Related
- 1993-08-17 ES ES94908117T patent/ES2145129T3/es not_active Expired - Lifetime
- 1993-08-17 AT AT94908117T patent/ATE191716T1/de not_active IP Right Cessation
-
1995
- 1995-03-15 US US08/387,745 patent/US5614633A/en not_active Expired - Fee Related
-
1996
- 1996-06-27 US US08/673,207 patent/US5874446A/en not_active Expired - Fee Related
-
1998
- 1998-02-19 US US09/026,127 patent/US5977167A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5614633A (en) | 1997-03-25 |
| EP0655448A1 (en) | 1995-05-31 |
| DE69328366T2 (de) | 2000-08-10 |
| DE69328366D1 (de) | 2000-05-18 |
| EP0655448B1 (en) | 2000-04-12 |
| ATE191716T1 (de) | 2000-04-15 |
| US5977167A (en) | 1999-11-02 |
| WO1994004521A1 (fr) | 1994-03-03 |
| US5874446A (en) | 1999-02-23 |
| CA2142471A1 (en) | 1994-03-03 |
| AU4761693A (en) | 1994-03-15 |
| KR950702976A (ko) | 1995-08-23 |
| CN1086817A (zh) | 1994-05-18 |
| EP0655448A4 (zh) | 1995-06-07 |
| ES2145129T3 (es) | 2000-07-01 |
| CN1044605C (zh) | 1999-08-11 |
| KR100231634B1 (ko) | 1999-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW258735B (zh) | ||
| SG52734A1 (en) | Novel benzopyran derivatives | |
| HU9502512D0 (en) | Anthranilic acid derivative | |
| CY2488B1 (en) | New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for trea. | |
| NO931529D0 (no) | Cykliske fruktopyranosesulfitter og -sulfater med antikonvulsiv effekt | |
| MY138525A (en) | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | |
| ATE184194T1 (de) | Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton | |
| DE69533727D1 (en) | Anilin-derivate als stickstoffmonoxid synthase-inhibitoren | |
| TW271435B (zh) | ||
| ATE53585T1 (de) | Penemverbindungen, ihre herstellung und verwendung. | |
| KR0184608B1 (en) | Novel benzopyran derivative | |
| YU83993A (sh) | Novi derivati piridon organske kiseline | |
| DE3770359D1 (de) | 6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung. | |
| WO1993005048A3 (de) | Herbizide sulfonylharnstoffe, verfahren und zwischenprodukte zu ihrer herstellung | |
| DE69031730D1 (de) | Neues Antibiotikum, Deoxymulündocandin, Verfahren zu seiner Produktion und Verwendung als Medikament | |
| ATE201200T1 (de) | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazol- derivate, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als herzfrequenzsenkendes mittel | |
| ATE113047T1 (de) | 2-fluorneplanocin a und seine herstellung. | |
| DE69711506D1 (de) | Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung | |
| TH13639A (th) | เบนโซไพรานและแอนทาโกนิสของ ltb4 ที่สัมพันธ์กัน | |
| MX9704411A (es) | Compuestos triciclicos. |