TW202203890A - Body cleansing agent - Google Patents

Abstract

A body cleanser having antimicrobial activity against alkaliphilic microbes that are associated with bacterial contamination of liquid cleansers. The body cleanser comprises a liquid composition that contains (A) an anionic surfactant, at least 0.10 mass% of (B) a chelating agent, and water, the liquid composition being prepared so as to have a pH of at least 9.0.

Description

body cleanser

The present invention relates to a body cleanser for body cleansing when bathing, washing face, etc., and more specifically, to a liquid body cleanser having antibacterial properties against basophilic bacteria.

Usually, in the case of preservative design for preparations such as detergents or cosmetics, in addition to considering the self-preservative properties of the ingredients usually included in the preparation, it is also necessary to select the best ingredients with preservative effect as appropriate, and deploy an appropriate amount.

In particular, body cleanser compositions, which are bath products used in bathrooms and toilets such as shampoos and body washes, are liquids containing water, so they tend to deteriorate. The demand for products, etc. is also increasing, and the chance of contamination by bacteria during use or refilling also increases. Therefore, it is necessary to add a preservative design to the preparation of liquid detergents for hand-washing (Non-Patent Document 1).

Among them, it is believed that alkaline body washes have strong antiseptic properties due to the antibacterial properties of the ingredients usually prepared. Moreover, since there are fewer bacteria species growing in an alkaline environment, the alkaline body cleansers are the most common ones in alkaline body cleansers. The design basis for corrosion resistance is not yet clear.

In addition, since some examples of contamination by gram-negative bacilli, which are part of the alkalophilic species, have occurred, it is considered that it is necessary to ensure the antibacterial power against basophilic bacterial species in refilling cleaning agents such as body washes. For example, it is known that in commercially available shampoos or conditioners, acid-type preservatives mainly containing benzoic acid and its salts, or isothiazoline-based preservatives are formulated into detergents, but these preservatives are in On the alkaline side, it is difficult to obtain a stable effect (Non-Patent Document 2).

In order to prevent itching of the scalp or skin, it is preferable to adjust the pH value of a cleaning agent such as shampoo to a weakly acidic side. The cleaning composition which consists of a chelating agent (patent document 1). [Prior Art Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 2001-131592 [Non-patent literature]

[Non-patent literature] [Non-Patent Document 1] Furuta Taro, Fragrance Journal (Fragrance J.), 1993 issue, September issue, p.59-64 [Non-Patent Document 2] Kensuke Tanaka, Journal of the Japan Cosmetic Technologist, Published in 1997, Vol. 31, No. 3, p.245-253

[Problems to be Solved by Invention]

However, as described in Patent Document 1, a cleansing agent in which a chelating agent is added and a cationic surfactant or the like is formulated to enhance the efficacy of the antibacterial agent is only for the purpose of antipruritic, deodorant, and antidandruff effects on the scalp or body. Those who became weakly acidic did not consider the antibacterial properties related to bacterial contamination of detergents by alkalophilic bacteria as a technical issue.

The above-mentioned alkalophilic bacteria are bacteria that can grow under the conditions of pH value above 9, which are difficult for ordinary bacteria to grow. Alkaline microorganisms, and bacteria belonging to the genus Halomonas are absolutely basophilic microorganisms that can only grow under the conditions of pH 9 or higher, and have not yet obtained sufficient antibacterial properties against these alkalophilic microorganisms. Insights on body cleansers.

Therefore, an object of the present invention is to create a liquid body which has sufficient antibacterial properties against alkalophilic bacteria, has antibacterial properties against basophilic bacteria related to bacterial contamination of liquid detergents, and is excellent in antiseptic effect A cleaning agent, especially a liquid body cleaning agent that can prevent secondary pollution of alkalophilic bacteria during use and refilling. [Technical means to solve problems]

Based on the fact that anionic surfactants have a weak antiseptic effect on the alkaline side with a pH value of 9.0 or more, especially the antibacterial activity against alkalophilic bacteria is almost zero, the inventors of the present case have continuously conducted keen research and found that, By deploying a specific amount of chelating agent, the antibacterial power can also be improved on the alkaline side, especially the antibacterial power against basophilic bacteria can be improved, and if the antiseptic effect agent is used in combination, the antibacterial power is further improved, and The above problems can be solved.

That is, in order to solve the above-mentioned problems, the present invention provides a body cleanser comprising a liquid composition containing (A) an anionic surfactant and (B) a chelating agent in an amount of 0.10% by mass or more, and Prepared to a pH value of 9.0 or higher.

The above-mentioned body cleanser of the present invention comprising the liquid composition contains (A) an anionic surfactant excellent in cleansing power to the skin and the like, and is prepared to have a pH value of 9.0 or higher, so that (B) the chelating agent can be more effective It exerts its antibacterial effect on alkalophilic bacteria. Alkaliophilic bacteria have the ability to form chemical osmotic pressure due to their protein and biofilm lipids that will not be modified under strong alkaline conditions. Therefore, under alkaline conditions, the metal blocking effect of chelating agents can easily reach the cell membrane. Inside.

According to the results of the following examples, it can also be considered that 0.10% by mass or more of the chelating agent contained in the body cleanser and the metal ions contained in the cell walls of the basophilic bacteria form mision ions, which play a role in metal sealing with high addition efficiency. The inhibitory effect can inhibit the production of enzymes required for the habitat or proliferation of the above-mentioned bacteria, and exert excellent antibacterial effect.

Furthermore, the above-mentioned liquid composition contains (C) an antiseptic agent as an additive component in addition to the above-mentioned chelating agent, whereby, even under a wider variety of bacterial species or use conditions including alkalophilic bacterial species, it is possible to improve the Antibacterial and antiseptic properties of body cleansers.

If the above-mentioned (A) anionic surfactant is used, it is preferably selected from higher fatty acids, N-acylglutamic acid, N-acylglycine, N-acylsarcosine, N-acyl-β- Alanine, N-Acyl-N-Methyl-β-Alanine, N-Acyl Aspartic Acid, N-Acyl-N-Methyl Taurine, Alkyl Sulfuric Acid, Polyoxyethylene Alkyl Sulfuric Acid , α-olefin sulfonic acid, alkyl phosphoric acid, or at least one or two or more of these neutralized salts, a body cleanser with stable quality that exerts the above-mentioned effects can be obtained.

In addition, in order to stably exert the antibacterial properties obtained by the metal blocking effect on alkalophilic bacteria, the above-mentioned (B) chelating agent is preferably selected from ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, Or at least one or two or more of these salts.

Furthermore, in order to improve the antibacterial properties and antiseptic properties of the body cleansing agent, as the above-mentioned (C) antiseptic effect agent, it is preferable to use a compound selected from the group consisting of phenoxyethanol, ethylhexylglycerol, caprylic acid glyceride, hexylglycerol, and cyclohexylglycerol. At least one or two or more of glycerol, iodopropynyl butylcarbamate, and silver oxide.

Then, the above-mentioned liquid composition may contain additional components as needed, for example, may contain one or more selected from the group consisting of (D) amphoteric surfactant, (E) nonionic surfactant, and (F) cellulose based tackifier. . [Effect of invention]

The present invention makes a body cleanser comprising the following liquid composition, the liquid composition contains an anionic surfactant and a specific amount of chelating agent, and is prepared to have a pH value of 9.0 or higher, so the body cleanser becomes a high The alkalophilic bacteria are efficiently subjected to the action of the chelating agent to have sufficient antibacterial properties, and the antiseptic effect is excellent. In addition, there is also the advantage that the preservative design of the body cleanser in the form of a formulation can be realized, so that it can withstand secondary pollution in the environment of use and refill.

A body cleanser according to an embodiment of the present invention is a liquid composition containing an anionic surfactant, a specific amount of a chelating agent, and water, and each component is prepared to have a pH value of 9.0 or more. The adjustment of the pH value can be carried out according to the usual practice, for example, an alkali agent such as potassium hydroxide can be added to adjust the pH value to 9.0 or higher.

As a specific example of the said (A) anionic surfactant, the following can be illustrated, and the thing other than these can also be employ|adopted according to the required cleaning power. For example, higher fatty acids such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, behenic acid, coconut oil fatty acid, palm kernel oil fatty acid, etc. can be exemplified; or N-lauroglutamic acid, N-cocoglutamic acid, N-lauroglycine, N-cocoglycine, N-laurosarcosine, N-cocosarcosine , N-lauroyl-beta-alanine, N-cocoyl-beta-alanine, N-lauroyl-N-methyl-beta-alanine, N-cocoyl-N-methyl N-alanine, N-lauro-aspartic acid, N-coco-aspartic acid, etc.; or N-lauro-N-methyl taurine, N- -N-acyl-N-methyl taurine such as cocoyl-N-methyl taurine; or at least one or more of lauryl sulfuric acid, polyoxyethylene lauryl sulfuric acid, and lauryl phosphoric acid .

Moreover, at least 1 type or 2 or more types selected from the salt of the said anionic surfactant and a neutralizing agent can be mentioned. Above-mentioned neutralization salt is selected from sodium, potassium, ammonium, triethanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, 2- At least one or two or more of amino-2-hydroxymethyl-1,3-propanediol, arginine, etc., but not limited to these.

The above-mentioned (B) chelating agent is not particularly limited, and specific examples can be exemplified: selected from the group consisting of disodium EDTA, trisodium EDTA, tetrasodium EDTA-4Na (EDTA-4Na), ethylenediaminetetraacetate Dipotassium amine tetraacetate, tetrapotassium ethylenediaminetetraacetate, trisodium hydroxyethylethylenediaminetriacetate, trisodium nitrotriacetate, pentasodium diethylenetriaminepentaacetate (pentasodium pentetate), At least one or two or more of hydroxyethanediphosphonic acid, disodium hydroxyethanediphosphonate, tetrasodium 3-hydroxy-2,2'-iminodisuccinate, and octylhydroxamic acid.

Moreover, by making the compounding quantity of these into 0.10 mass % or more, the antibacterial power with respect to an alkalophilic strain can be improved extremely. In addition, the upper limit of the compounding quantity should just be in the range which does not impair the quality stability and safety|security of a liquid composition. For example, it is 1.0 mass % or less, and in the following examples, better results can be obtained by blending 0.4 mass % or less.

The above-mentioned (C) antiseptic effect agent is not particularly limited, and known components with antiseptic effect can be used, and specific examples include: phenoxyethanol, ethylhexylglycerol, caprylic acid glyceride, hexylglycerol, cyclohexylglycerol , at least one or two or more of isopropylmethylphenol, iodopropynyl butylcarbamate, silver oxide, etc. The blending amount varies depending on the selected components, but in order to fully exert the antiseptic effect, it is preferably 0.001% or more, and an appropriate amount can be blended within a range that takes into consideration safety such as irritation or quality stability.

In addition to the above components (A), (B), and (C), in order to improve the usability or usability of the body cleanser, (D) amphoteric surfactants and (E) nonionic surfactants can be formulated in addition to moisture. Surfactant, (F) Cellulose based tackifier.

(D) The amphoteric surfactant is not particularly limited, and specific examples include: more preferably, it is selected from the group consisting of sodium cocoamphoacetate, sodium lauroamphoacetate, betaine lauryl dimethylaminoacetate, nutmeg Dimethylaminoacetic acid betaine, cocoalkyldimethylaminoacetic acid betaine, laurylaminopropyl dimethylaminoacetic acid betaine, myristamidopropyl dimethylaminoacetic acid betaine, coconut oil Fatty Amidopropyl Dimethylamino Acetate Betaine, Palm Kernel Oil Fatty Amidopropyl Dimethyl Amino Acetate Betaine, Lauryl Dimethyl Amino Hydroxy Sulfobetaine, Myristyl Dimethyl Amino Hydroxy Sulfonate Betaine, Cocoalkyl Dimethyl Amino Hydroxy Sultaine, Lauryl Amidopropyl Dimethyl Amino Hydroxy Sultaine, Myristyl Amidopropyl Dimethyl Amino Hydroxy Sultaine, Coconut Oil Fat Amidopropyl Dimethyl Amino Hydroxy Sultaine, Palm Kernel Oil Fat Amidopropyl Dimethyl Amino Hydroxy Sultaine, Lauryl Dimethyl Amine Oxide, Myristyl Dimethyl Ammonium Oxide , Coco Alkyl Dimethyl Amine Oxide, Lauryl Aminopropyl Dimethyl Ammonium Oxide, Myristyl Aminopropyl Dimethyl Ammonium Oxide, Coconut Fatty Aminopropyl Dimethyl Ammonium Oxide, Palm Kernel Oil At least one or two or more of fatty amide propyl dimethyl amine oxide and the like.

The above-mentioned (E) nonionic surfactant is not particularly limited, and specific examples are preferably selected from the group consisting of coconut oil fatty acid monoethanolamide, lauric acid monoethanolamide, lauric acid diethanolamide, and myristate diethanolamide Amine, Coconut Fatty Acid Diethanolamide, Palm Kernel Fatty Acid Diethanolamide, Coconut Fatty Acid N-Methyl Monoethanolamide, Polyoxyethylene Lauric Acid Monoethanolamide, Polyoxyethylene Coconut Fatty Acid Monoethanolamide At least one of amine, polyoxypropylene laurate monoethanolamide, polyoxypropylene coconut fatty acid monoethanolamide, lauryl glycol hydroxypropyl ether, (lauryl/myristyl) glycol hydroxypropyl ether, etc. one or both.

The above-mentioned (F) cellulose-based tackifier is not particularly limited, and specific examples are selected from the group consisting of carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose gum, At least one or two or more of carboxymethyl hydroxyethyl cellulose, hydroxypropyl methyl cellulose stearyl ether, and the like.

Furthermore, in the range which does not impair the effect of this invention, a well-known base agent or a carrier added to a body cleanser can be mixed and used. In addition, for example, other surfactants, oils, alcohols, humectants, preservatives, antioxidants, pH adjusters, stabilizers, dispersants, fragrances, colorants, pigments, pearlescent imparting agents, blood circulation can also be formulated Boosting ingredients, ultraviolet absorbing ingredients, ultraviolet scattering ingredients, astringent ingredients, peptides, amino acids, keratolytic ingredients, cell activating ingredients, solubilizers, water, etc. Additives may be used alone or in combination of two or more.

As the above-mentioned alcohols, those selected from the group consisting of ethanol, isopropanol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 2-methyl-1,3-butanediol, One or more of propylene glycol, polypropylene glycol, polyethylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, glycerol, and diglycerol. [Example]

[Example 1-4, Comparative Example 1-19] Hereinafter, an Example and a comparative example are shown, and this invention is demonstrated more concretely. The "%" shown in the following examples and the following tables are all "mass %".

The compound names of the chelating agent and the antiseptic effect agent as specific components in the body cleanser whose composition is shown in Table 1 and the component amounts (mass %) in the above-mentioned compositions are shown in Table 2, Table 3, and Table 4. The above-mentioned body cleanser is prepared by stirring and mixing the raw materials at the mixing ratio shown in the above table according to a conventional method, so that the remainder of the ingredients is water so as to be 100% by mass to prepare a liquid composition.

< Preservative Power Determination Test > According to the Japanese Pharmacopoeia 17th Edition antiseptic efficacy test method, the compositions of the examples and comparative examples prepared in the above manner were tested. Inoculated with a mixture of Echerichia coli, Pseudomonas aeruginosa, Staphylococcus aureus (hereinafter referred to as "the three mixtures"), and Halomonas meridiana (hereinafter It is abbreviated as "HM bacteria") to make the bacteria concentration of 10 ⁶ CFU/g level in the composition, and the presence or absence of the bacteria number after inoculation was observed 14 days.

In addition, the test results with respect to three kinds of mixed bacteria and HM bacteria are shown in Table 2, Table 3, and Table 4. The abbreviation N.D. shown in these tables means "no bacteria detected", the mark + means "bacteria detected", and the mark - means "not formulated". In addition, the cocoamide DEA (Diethanolamine, diethanolamine) in the table represents the coconut oil fatty acid diethanolamide, and the cocoamide MEA (Monoethanolamide, monoethanolamide) is the abbreviation of the coconut oil fatty acid monoethanolamide.

In addition, Table 2 shows the pH dependence of growth of HM bacteria, which were prepared to pH 7 to 10.5 by adding potassium hydroxide to the body cleanser of Table 1 to adjust pH.

According to the results in Table 2, HM bacteria will not grow under the conditions of pH 8.0 or lower in Comparative Examples 1 and 2, while HM bacteria will grow under the conditions of pH 9.0 or higher in Comparative Examples 3 to 5. Based on the test results, Comparative Examples 6 to 17 shown in Table 3, Examples 1 to 4 shown in Table 4, and Comparative Examples 18 and 19 were carried out under the condition that the pH value was adjusted to 9.0 or more.

[Table 1] composition % myristic acid 4.0 Lauric acid 4.0 Palmitic acid 2.0 Cocamidopropyl Betaine 4.0 Lauroaminopropyl Betaine 4.0 Sodium Olefin (C14-16) Sulfonate 2.5 Cocoamide DEA 1.0 Cocoamide MEA 1.0 spices Moderate Potassium hydroxide Moderate chelating agent ※1 Antiseptic effect agent ※2 water The remaining part (*1 and *2 in the table represent the amount recorded in Table 2 or Table 3)

[Table 2] type Compound name Comparative example 1 2 3 4 5 chelating agent Pentasodium pentarate - - - - - EDTA-4Na - - - - - Antiseptic effect agent Phenoxyethanol - - - - - 1,2-Pentanediol - - - - - 1,2-Hexanediol - - - - - 1,2-Octanediol - - - - - Ethylhexylglycerin - - - - - Glyceryl Caprylate - - - - - Hexylglycerol - - - - - Cyclohexylglycerol - - - - - Cetylpyridinium Chloride - - - - - [Table 1] Preparation pH of the composition 7.0 8.0 9.0 10.0 10.5 Detection after 14 days of HM inoculation ND ND + + +

[table 3] type Compound name Comparative example 6 7 8 9 10 11 chelating agent Pentasodium pentarate 0.08 0.08 0.08 0.08 0.08 0.08 EDTA-4Na - - - - - - Antiseptic effect agent Phenoxyethanol - 1 - - - - 1,2-Pentanediol - - 2 2 2 2 1,2-Hexanediol - - - - - - 1,2-Octanediol - - - - - - Ethylhexylglycerin - - - 1 - - Glyceryl Caprylate - - - - 1 - Hexylglycerol - - - - - - Cyclohexylglycerol - - - - - - Cetylpyridinium Chloride - - - - - 1 [Table 1] Preparation pH of the composition 9.7 9.8 9.8 9.8 9.9 9.8 Detection after 14 days of inoculation of the three mixed bacteria ND ND ND ND ND ND Detection after 14 days of HM inoculation + + + + + + type Compound name Comparative example 12 13 14 15 16 17 chelating agent Pentasodium pentarate 0.08 0.08 0.08 0.08 0.08 0.08 EDTA-4Na - - - - - - Antiseptic effect agent Phenoxyethanol - - - - - - 1,2-Pentanediol - - - - - - 1,2-Hexanediol - - - - - - 1,2-Octanediol 0.5 - - - - - Ethylhexylglycerin - 1 - - - - Glyceryl Caprylate - - 1 - - - Hexylglycerol - - - 1 - - Cyclohexylglycerol - - - - 2 - Cetylpyridinium Chloride - - - - - 1 [Table 1] Preparation pH of the composition 9.7 9.9 9.8 9.9 9.8 10.0 Detection after 14 days of inoculation of the three mixed bacteria ND ND ND ND ND ND Detection after 14 days of HM inoculation + + + + + +

From the results shown in Table 3, it can be seen that the cleaning agents of Comparative Examples 6-17 were prepared with 0.08% by mass of pentasodium pentaacid, and no antiseptic effect agent or various antiseptic effect agents were prepared, although three kinds of mixed The antibacterial properties of all the bacteria were killed, but the HM bacteria were not killed, so the sufficient antibacterial properties could not be obtained.

[Table 4] type Compound name Comparative example Example 18 19 1 2 3 4 chelating agent Pentasodium pentarate - - 0.2 0.2 - - EDTA-4Na 0.08 0.08 - - 0.4 0.4 Antiseptic effect agent Phenoxyethanol - 1 - 0.2 - 0.2 1,2-Pentanediol - - - - - - 1,2-Hexanediol - - - - - - 1,2-Octanediol - - - - - - Ethylhexylglycerin - - - - - - Glyceryl Caprylate - - - - - - Hexylglycerol - - - - - - Cyclohexylglycerol - - - - - - Cetylpyridinium Chloride - - - - - - [Table 1] Preparation pH of the composition 9.9 9.8 10.0 9.8 9.8 9.9 Detection after 14 days of inoculation of the three mixed bacteria ND ND ND ND ND ND Detection after 14 days of HM inoculation + + ND ND ND ND

In addition, from the results shown in Table 4, it can be seen that in Comparative Example 18 and Comparative Example 19 in which 0.08% by mass of tetrasodium EDTA was prepared, as in Comparative Examples 6-17, all the three kinds of mixed bacteria were killed, but no effect was observed. Can kill HM bacteria.

On the other hand, in Examples 1-4 in which pentasodium pentaate or tetrasodium EDTA was prepared in an amount exceeding 0.08% by mass, the HM bacteria and the three kinds of mixed bacteria were all killed, and it was considered that they had sufficient resistance to alkali-resistant bacteria. of antibacterial power.

From the above results, when the amount of the chelating agent was less than 0.1% by mass, it was confirmed that the antibacterial activity against alkali-resistant bacteria (Halomonas meridiana) was relatively poor, and when the amount of the chelating agent was more than 0.1% by mass, it was confirmed that the antibacterial activity was sufficient. Formulation examples of the body cleanser of the present invention are shown below. Furthermore, DPG in the table is an abbreviation for dipropylene glycol, PPG is an abbreviation for propylene glycol, BG is an abbreviation for butanediol, and PCA is an abbreviation for pyrrolidone carboxylic acid.

(Formulation example 1) Body wash (whole body cleanser) [Table 5] composition % Pentasodium pentarate 0.2 Phenoxyethanol 0.2 myristic acid 4.0 Lauric acid 4.0 Cocamidopropyl Betaine 4.0 Lauroaminopropyl Betaine 4.0 Sodium Olefin (C14-16) Sulfonate 2.5 Potassium hydroxide 2.5 Palmitic acid 2.0 DPG 1.0 Cocoamide DEA 1.0 Cocoamide MEA 1.0 Polyquaternary ammonium salt-50 0.2 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned antiseptic power test on Formulation Example 1, it was confirmed that the antiseptic power was sufficient for both the HM bacteria and the three kinds of mixed bacteria.

(Formulation example 2) Body wash (whole body cleanser) [Table 6] composition % Pentasodium pentarate 0.2 Phenoxyethanol 0.2 Lauric acid 7.5 myristic acid 4.0 Potassium hydroxide 4.0 DPG 3.0 Palmitic acid 1.5 Sodium Laureth Sulfate 1.5 Cocamidopropyl Betaine 1.0 glycerin 1.0 Cocoamide methyl MEA 1.0 Hydroxypropylmethylcellulose 1.0 Laurylaminopropylamine oxide 1.0 Cocoamide MEA 0.5 Potassium Cocoglycinate 0.5 ε-aminocaproic acid 0.1 Stearyl Glycyrrhetinate 0.05 purified water The remaining part total 100.0

As a result of carrying out the above-described preservative determination test for Formulation Example 2, it was confirmed that the preservatives were sufficient for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 3) Body wash (whole body cleanser) [Table 7] composition % EDTA-2Na 0.2 silver oxide 0.001 Potassium soap green 15.0 Lauroaminopropyl Betaine 5.0 Cocoamide methyl MEA 3.0 Ethylene glycol distearate 3.0 glycerin 1.5 Palmitic acid 1.0 PPG-9 0.5 Potassium hydroxide 0.1 DPG 1.0 Silicon spirit 100,000 cps 1.0 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 3, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 4) Body wash (whole body cleanser) [Table 8] composition % Pentasodium pentarate 0.2 silver oxide 0.001 Potassium soap green 15.0 Lauroaminopropyl Betaine 5.0 Cocoamide methyl MEA 3.0 Ethylene glycol distearate 3.0 glycerin 1.5 Palmitic acid 1.0 PPG-9 0.5 Potassium hydroxide 0.1 DPG 1.0 Silicon spirit 100,000 cpS 1.0 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 4, it was confirmed that the preservatives were sufficient for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 5) Body wash (whole body cleanser) [Table 9] composition % EDTA-4Na 0.2 Potassium soap embryo 20.0 glycerin 7.5 Cocoamide methyl MEA 3.5 Ethylene glycol distearate 3.0 Cocamidopropyl Betaine 2.0 Acrylate copolymer 1.0 Lauryl Hydroxy Sultaine 1.0 Menthol 0.5 (PCA/Isostearic Acid) PEG-40 Hydrogenated Castor Oil 0.5 1,2-Hexanediol 0.5 Glyceryl Caprylate 1.0 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 5, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 6) Body wash (whole body cleanser) [Table 10] composition % Pentasodium pentarate 0.2 Iodopropynyl Butylcarbamate 0.02 myristic acid 7.5 glycerin 6.0 Cocoamide DEA 6.0 Lauric acid 6.0 Potassium hydroxide 4.5 Sodium Cocoamphoacetate 4.5 disodium monolauryl phosphate 2.0 Laurylaminopropylamine oxide 2.0 BG 1.0 Methyl glucose 10 ethylene oxide 1.0 purified water The remaining part total 100.0

As a result of the above-mentioned preservative determination test for Formulation Example 6, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 7) Body wash (whole body cleanser) [Table 11] composition % Pentasodium pentarate 0.2 1,2-Pentanediol 2.0 myristic acid 4.0 Lauric acid 4.0 Cocamidopropyl Betaine 4.0 Lauroaminopropyl Betaine 4.0 Sodium Olefin (C14-16) Sulfonate 2.5 Potassium hydroxide 2.5 Palmitic acid 2.0 DPG 1.0 Cocoamide DEA 1.0 Cocoamide MEA 1.0 Polyquaternary ammonium salt-50 0.2 isopropyl methylphenol 0.1 Dipotassium Glycyrrhizinate 0.1 purified water The remaining part total 100.0

As a result of the above-mentioned preservative determination test for Formulation Example 7, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 8) Body wash (whole body cleanser) [Table 12] composition % Pentasodium pentarate 0.2 1,2-Hexanediol 1.0 Lauric acid 7.5 myristic acid 4.0 Potassium hydroxide 4.0 DPG 3.0 Palmitic acid 1.5 Sodium Laureth Sulfate 1.5 Cocamidopropyl Betaine 1.0 glycerin 1.0 Cocoamide methyl MEA 1.0 Hydroxypropylmethylcellulose 1.0 Laurylaminopropylamine oxide 1.0 Cocoamide MEA 0.5 Potassium Cocoglycinate 0.5 Glycyrrhetinic acid 0.1 Niacin 0.5 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 8, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 9) Body wash (whole body cleanser) [Table 13] composition % Pentasodium pentarate 0.2 1,2-Octanediol 0.5 Potassium soap green 15.0 Lauroaminopropyl Betaine 5.0 Cocoamide methyl MEA 3.0 Ethylene glycol distearate 3.0 glycerin 1.5 Palmitic acid 1.0 PPG-9 0.5 Potassium hydroxide 0.1 purified water The remaining part total 100.0

As a result of the above-mentioned preservative determination test for Formulation Example 9, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 10) Body wash (whole body cleanser) [Table 14] composition % EDTA-4Na 0.2 1,2-Pentanediol 2.0 Ethylhexylglycerin 1.0 Potassium soap embryo 20.0 glycerin 7.5 Cocoamide methyl MEA 3.5 Ethylene glycol distearate 3.0 Cocamidopropyl Betaine 2.0 Acrylate copolymer 1.0 Lauryl Hydroxy Sultaine 1.0 Menthol 0.5 (PCA/Isostearic Acid) PEG-40 Hydrogenated Castor Oil 0.5 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 10, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 11) Body wash (whole body cleanser) [Table 15] composition % EDTA-4Na 0.4 Octylhydroxamic acid 0.1 myristic acid 7.5 glycerin 6.0 Cocoamide DEA 6.0 Lauric acid 6.0 Potassium hydroxide 4.5 Sodium Cocoamphoacetate 4.5 Palmitic acid 2.0 Laurylaminopropylamine oxide 2.0 BG 1.0 Methyl glucose 10 ethylene oxide 1.0 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 11, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three mixed bacteria.

(Formulation example 12) Body wash (whole body cleanser) [Table 16] composition % EDTA-4Na 0.4 Cyclohexylglycerol 2.0 myristic acid 7.5 glycerin 6.0 Cocoamide DEA 6.0 Lauric acid 6.0 Potassium hydroxide 4.5 Sodium Cocoamphoacetate 4.5 Palmitic acid 2.0 Laurylaminopropylamine oxide 2.0 BG 1.0 Methyl glucose 10 ethylene oxide 1.0 purified water The remaining part total 100.0

As a result of carrying out the above-mentioned preservative determination test for Formulation Example 12, it was confirmed that the preservatives have sufficient preservatives for both the HM bacteria and the three types of mixed bacteria.

(Formulation example 13) Body wash (whole body cleanser) [Table 17] composition % EDTA-4Na 0.4 Hexylglycerol 2.0 myristic acid 7.5 glycerin 6.0 Cocoamide DEA 6.0 Lauric acid 6.0 Potassium hydroxide 4.5 Sodium Cocoamphoacetate 4.5 Palmitic acid 2.0 Laurylaminopropylamine oxide 1.0 BG 1.0 Methyl glucose 10 ethylene oxide 1.0 purified water The remaining part total 100.0

As a result of the above-described preservative determination test for Formulation Example 13, it was confirmed that the preservatives had sufficient preservatives for both the HM bacteria and the three mixed bacteria. [Industrial Availability]

The present invention relates to a body cleaning agent for body cleaning containing surfactant, for example, it can be used as shower gel (body cleaning agent), hand lotion (hand washing cleaning agent), shampoo (hair cleaning agent), and other liquid formulations, it is a general-purpose body cleanser that is used in other beauty fields related to cosmetics or in various industries such as life, health, and medical fields.

Claims (6)

A body cleanser comprising a liquid composition containing (A) an anionic surfactant and (B) a chelating agent of 0.10 mass % or more, and prepared to have a pH value of 9.0 or more. The body cleanser according to claim 1, wherein the (A) anionic surfactant is selected from higher fatty acids, N-acylglutamic acid, N-acylglycine, N-acylsarcosine, N -Acidyl-β-alanine, N-acyl-N-methyl-β-alanine, N-acyl-aspartic acid, N-acyl-N-methyl taurine, alkyl sulfuric acid, At least one or two or more of polyoxyethylene alkyl sulfuric acid, α-olefin sulfonic acid, alkyl phosphoric acid, or neutralized salts thereof. The body cleanser according to claim 1 or 2, wherein the (B) chelating agent is at least one or two or more selected from ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, or salts thereof. The body cleanser according to any one of claims 1 to 3, wherein the above-mentioned liquid composition contains (C) a preservative agent (excluding a chelating agent) as an additive component. The body cleanser according to claim 4, wherein the (C) antiseptic effect agent is selected from the group consisting of phenoxyethanol, ethylhexylglycerol, glyceryl caprylate, hexylglycerol, cyclohexylglycerol, iodopropyne butylcarbamate At least one or two or more of ester and silver oxide. The body cleanser according to any one of claims 1 to 4, wherein the above-mentioned liquid composition contains a compound selected from the group consisting of (D) amphoteric surfactants, (E) nonionic surfactants and (F) cellulose-based tackifiers One or more of the agents are used as additives.