TW202106322A - Essential oil composition for sleep, and use thereof - Google Patents
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Abstract
Description
本發明係關於一種舒眠精油組合物，特別關於一種舒眠精油組合物。本發明另關於該舒眠精油組合物的用途。The present invention relates to a sleep-relieving essential oil composition, and particularly relates to a sleep-relieving essential oil composition. The present invention also relates to the use of the sleep-relieving essential oil composition.
芳香療法（aromatherapy）是指以植物所萃取出的精油（essential oil）作為媒介，經由按摩（massage）、泡澡（bath）、薰香（aerial dissusion）等方式，經由呼吸道或皮膚吸收進入體內，來達到舒緩精神壓力的自然療法。舉例而言，薰衣草精油可以用於減輕焦慮（anxiety）、治療失眠症（insomnia）等睡眠障礙（sleep disturbance）。Aromatherapy refers to the use of essential oils extracted from plants as a medium, which is absorbed into the body through the respiratory tract or skin through massage, bath, and aerial dissusion. To achieve natural remedies to relieve mental stress. For example, lavender essential oil can be used to relieve anxiety and treat sleep disturbances such as insomnia.
然而，單純使用薰衣草精油來改善睡眠品質（sleep quality）的效果仍有待改善的空間，若是能夠佐以他種不同的精油，藉此提升其效果，確實有助於提升國人的睡眠健康。However, the effect of simply using lavender essential oil to improve sleep quality still has room for improvement. If it can be supplemented with other kinds of essential oils to enhance its effect, it will indeed help improve the sleep health of Chinese people.
為解決上述問題，本發明的目的係提供一種舒眠精油組合物，其具有優於薰衣草精油單方的效果者。In order to solve the above-mentioned problems, the object of the present invention is to provide a sleep-relieving essential oil composition, which has a better effect than the single lavender essential oil.
本發明的另一目的係提供一種舒眠精油組合物的用途，係以前述的舒眠精油組合物來製備改善睡眠品質的製劑者。Another object of the present invention is to provide a use of the sleep-relieving essential oil composition, which is to prepare a preparation for improving sleep quality by using the aforementioned sleep-relieving essential oil composition.
本發明的舒眠精油組合物，可以包含：以重量百分比計為10～20%之一薰衣草精油、5～15%之一岩蘭草精油、10～20%之一苦橙葉精油、5～15%之一馬鬱蘭精油、5～15%之一伊蘭伊蘭精油及30～60%之一薄荷精油。The sleep-relieving essential oil composition of the present invention may include: 10-20% lavender essential oil, 5-15% vetiver essential oil, 10-20% petitgrain essential oil, 5-15% by weight. % One marjoram essential oil, 5-15% ylang ylang essential oil, and 30-60% peppermint essential oil.
據此，本發明之舒眠精油組合物，藉由該薰衣草精油、該岩蘭草精油、該苦橙葉精油、該馬鬱蘭精油、該伊蘭伊蘭精油及該薄荷精油的加乘作用，有助於安定精神、抑制壓力、促進睡眠，使該舒眠精油組合物可以應用於製備改善睡眠品質的製劑，且其改善睡眠品質的效果顯著優於單方薰衣草精油，為本發明之功效。Accordingly, the sleep-relieving essential oil composition of the present invention, through the additive effect of the lavender essential oil, the vetiver essential oil, the petitgrain essential oil, the marjoram essential oil, the ylang ylang essential oil, and the peppermint essential oil, helps In order to stabilize the spirit, inhibit stress, and promote sleep, the sleep-relieving essential oil composition can be used to prepare preparations for improving sleep quality, and its effect of improving sleep quality is significantly better than that of single lavender essential oil, which is the effect of the present invention.
本發明的舒眠精油組合物，其中，較佳可以包含以重量百分比計為14.3%之薰衣草精油、9.5%之岩蘭草精油、14.3%之苦橙葉精油、9.5%之馬鬱蘭精油、9.5%之伊蘭伊蘭精油及42.9%之薄荷精油。如此，使該舒眠精油組合物具有較佳的改善睡眠品質效果。The sleep-relieving essential oil composition of the present invention may preferably comprise 14.3% lavender essential oil, 9.5% vetiver essential oil, 14.3% petitgrain essential oil, 9.5% marjoram essential oil, and 9.5% by weight. Ylang Ylang essential oil and 42.9% peppermint essential oil. In this way, the sleep-relieving essential oil composition has a better effect of improving sleep quality.
本發明的舒眠精油組合物的用途，係用以製備改善睡眠品質的製劑，該舒眠精油組合物係可以投予一所需個體，以改善該所需個體的睡眠品質。The use of the sleep-relieving essential oil composition of the present invention is to prepare a preparation for improving sleep quality. The sleep-relieving essential oil composition can be administered to a desired individual to improve the sleep quality of the desired individual.
據此，該舒眠精油組合物的用途係藉由該薰衣草精油、該岩蘭草精油、該苦橙葉精油、該馬鬱蘭精油、該伊蘭伊蘭精油及該薄荷精油的加乘作用，可以用於改善該所需個體的睡眠品質，並可以減少失眠症等的睡眠障礙的發生，減少該所需個體由於睡眠品質不佳所導致的精神不佳、易怒、抑鬱等症狀，更可以提升該所需個體的注意力及工作、學習效果，為本發明之功效。Accordingly, the use of the sleep-relieving essential oil composition is based on the additive effect of the lavender essential oil, the vetiver essential oil, the petitgrain essential oil, the marjoram essential oil, the ylang ylang essential oil and the peppermint essential oil. In order to improve the sleep quality of the individual in need, it can reduce the occurrence of sleep disorders such as insomnia, and reduce the symptoms of poor mentality, irritability, depression and other symptoms of the individual in need due to poor sleep quality, and can also improve the The individual's attention and work and learning effects are the effects of the present invention.
本發明的舒眠精油組合物的用途，該舒眠精油組合物係能夠以吸入性投予或經皮吸收的方式投予該所需個體。如此，由於該舒眠精油組合物的高滲透分子能夠經由皮脂腺或皮脂膜吸收，並經由血管及淋巴管快速循環至各組織器官，可以避免口服投予可能發生的肝首過效應（first pass effect），更可以延長作用時間並減少投予次數，不僅能夠提升治療效果、減少副作用發生的可能性，更可以增加該所需個體的用藥順從性（compliance）。The use of the sleep-relieving essential oil composition of the present invention can be administered to the desired individual in the form of inhalation administration or transdermal absorption. As such, since the high-permeability molecules of the sleep-relieving essential oil composition can be absorbed through the sebaceous glands or sebaceous membranes, and quickly circulate to various tissues and organs through blood vessels and lymphatic vessels, the possible first pass effect of oral administration can be avoided. ), it can prolong the action time and reduce the number of administrations, which can not only improve the therapeutic effect and reduce the possibility of side effects, but also increase the medication compliance of the required individual.
為讓本發明之上述及其他目的、特徵及優點能更明顯易懂，下文特舉本發明之較佳實施例，並配合所附圖式，作詳細說明如下：In order to make the above and other objectives, features and advantages of the present invention more comprehensible, the preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings:
本發明所述之「製劑」係指將一活性成分加工調製，製成特定劑型，且包含一定劑量之藥品及化妝品，而本發明所述之「改善睡眠品質的製劑」則可以縮減入睡前的等待時間，及提升睡眠持續時間，此為本發明所屬技術領域中具有通常知識者可以理解，於此不再贅述。The "preparation" described in the present invention refers to the processing and preparation of an active ingredient into a specific dosage form and containing a certain dose of medicines and cosmetics, while the "preparation for improving sleep quality" described in the present invention can reduce the amount of sleep before going to bed. The waiting time and the increased sleep duration are understood by those with ordinary knowledge in the technical field to which the present invention pertains, and will not be repeated here.
本發明所述之「睡眠品質」為判定睡眠好壞的重要指標，依據美國國家睡眠基金會（National Sleep Foundation）所發表的定義，良好的睡眠品質應同時包含：入睡前的等待時間＜30分鐘、半夜醒來（醒來時間≧5分鐘）的次數≦1次、半夜醒來的時間＜20分鐘，且睡眠效率（睡眠時間/躺床時間的百分比）≧85%。The "sleep quality" mentioned in the present invention is an important indicator for judging the quality of sleep. According to the definition published by the National Sleep Foundation (National Sleep Foundation), good sleep quality should also include: waiting time before going to bed <30 minutes , The number of waking up in the middle of the night (wake up time ≧ 5 minutes) ≦ 1 time, the time of waking up in the middle of the night <20 minutes, and the sleep efficiency (percentage of sleep time / bed time) ≧ 85%.
本發明所述之「睡眠障礙」，依據美國精神醫學學會（American Psychiatric Association）DSM-IV指南（Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition）的定義包含睡眠障礙的連續時間長達一個月以上，且睡眠障礙的程度已足以造成臨床上顯著的社會性、職業上或其他重要領域的痛苦或損害。一般常見的睡眠障礙包含：失眠症、嗜睡症（hypersomnia）及睡眠清醒周期失調（sleep-wake schedule disorder）等。The "sleep disorder" mentioned in the present invention, according to the American Psychiatric Association (American Psychiatric Association) DSM-IV guide (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), includes the continuous duration of sleep disorder for more than one month. And the degree of sleep disturbance is enough to cause clinically significant social, occupational or other important areas of pain or damage. Common sleep disorders include: insomnia, hypersomnia and sleep-wake schedule disorder.
本發明之一實施例的舒眠精油組合物可以包含一薰衣草精油、一岩蘭草精油、一苦橙葉精油、一馬鬱蘭精油、一伊蘭伊蘭精油及一薄荷精油，藉由該薰衣草精油、該岩蘭草精油、該苦橙葉精油、該馬鬱蘭精油、該伊蘭伊蘭精油及該薄荷精油的加乘作用，有助於安定精神、抑制壓力、促進睡眠，使該舒眠精油組合物可以應用於製備改善睡眠品質的製劑，且其改善睡眠品質的效果顯著優於單一精油（即，該薰衣草精油）。The sleep-relieving essential oil composition of an embodiment of the present invention may include one lavender essential oil, one vetiver essential oil, one petitgrass essential oil, one marjoram essential oil, one ylang ylang essential oil and one peppermint essential oil, by means of the lavender essential oil, The additive effect of the vetiver essential oil, the petitgrain essential oil, the marjoram essential oil, the ylang ylang essential oil and the peppermint essential oil helps to stabilize the spirit, inhibit stress, and promote sleep, so that the sleep-relieving essential oil composition can It is applied to the preparation of a preparation for improving sleep quality, and its effect of improving sleep quality is significantly better than that of a single essential oil (ie, the lavender essential oil).
詳而言之，該舒眠精油組合物可以包含以重量百分比計為10～20%之薰衣草精油（lavender essential oil），較佳可以包含以重量百分比計為14.3%的薰衣草精油，該薰衣草精油可以取自狹葉薰衣草（Lavandula angustifolia ），於本實施例中，係將一狹葉薰衣草樣品（例如，狹葉薰衣草的花等）於60～100℃之溫度下，進行蒸餾40～120分鐘所獲得。該薰衣草精油具有鎮痛、鎮靜、助眠、抗憂鬱及抗菌等效能。In detail, the sleep-relieving essential oil composition may contain 10-20% by weight of lavender essential oil (lavender essential oil), preferably may contain 14.3% by weight of lavender essential oil, and the lavender essential oil may Taken from Lavandula angustifolia . In this embodiment, a sample of Lavandula angustifolia (for example, the flower of Lavender angustifolia) is distilled at a temperature of 60-100°C for 40-120 minutes. . The lavender essential oil has analgesic, calming, sleep aid, anti-depression and antibacterial effects.
該舒眠精油組合物可以包含以重量百分比計為5～15%之岩蘭草精油（vetiver essential oil），較佳可以包含以重量百分比計為9.5%的岩蘭草精油，該岩蘭草精油可以取自岩蘭草（Chrysopogon zizanioides (Vetiveriazizanioides )），於本實施例中，係將一岩蘭草樣品（例如，岩蘭草的根等）於60～100℃之溫度下，進行蒸餾40～120分鐘所獲得。該岩蘭草精油具有鎮靜、抗憂鬱、安定精神及舒緩焦慮等效能。The sleep-relieving essential oil composition may contain 5-15% by weight of vetiver essential oil (vetiver essential oil), preferably may contain 9.5% by weight of vetiver essential oil, and the vetiver essential oil may be obtained from Vetiver ( Chrysopogon zizanioides ( Vetiveriazizanioides )), in this embodiment, is obtained by distilling a sample of vetiver (for example, the root of vetiver) at a temperature of 60-100°C for 40-120 minutes. The vetiver essential oil has sedative, anti-depressant, calming and anxiety-relieving effects.
該舒眠精油組合物可以包含以重量百分比計為10～20%之苦橙葉精油（petitgrain essential oil），較佳可以包含以重量百分比計為14.3%的苦橙葉精油，該苦橙葉精油可以取自苦橙（Citrus aurantiumamara ），於本實施例中，係將一苦橙樣品（例如，苦橙樹的葉等）於60～100℃之溫度下，進行蒸餾40～120分鐘所獲得。該苦橙葉精油具有促進睡眠、抗憂鬱及安定精神等效能。The sleep-relieving essential oil composition may comprise 10 to 20% by weight of petitgrain essential oil, preferably 14.3% by weight of petitgrain essential oil, the petitgrain essential oil It can be obtained from bitter orange ( Citrus aurantiumamara ). In this embodiment, a bitter orange sample (for example, leaves of bitter orange tree, etc.) is distilled at a temperature of 60-100° C. for 40-120 minutes. The bitter orange leaf essential oil has the effects of promoting sleep, anti-depression and calming spirits.
該舒眠精油組合物可以包含以重量百分比計為5～15%之馬鬱蘭精油（marjoram essential oil），較佳可以包含以重量百分比計為9.5%的馬鬱蘭精油，該馬鬱蘭精油可以取自馬鬱蘭（Thymus mastichina ），於本實施例中，係將一馬鬱蘭樣品（例如，馬鬱蘭的葉或花等）於60～100℃之溫度下，進行蒸餾40～120分鐘所獲得。該馬鬱蘭精油具有鎮靜、安定精神、抗菌及助眠等效能。The sleep-relieving essential oil composition may contain 5-15% by weight of marjoram essential oil, preferably 9.5% by weight of marjoram essential oil, and the marjoram essential oil may be obtained from marjoram ( Thymus mastichina ). In this embodiment, a sample of marjoram (for example, marjoram leaves or flowers, etc.) is distilled at a temperature of 60-100° C. for 40-120 minutes. The marjoram essential oil has sedative, calming spirit, antibacterial and sleep aid effects.
該舒眠精油組合物可以包含以重量百分比計為5～15%之伊蘭伊蘭精油（ylang ylang essential oil），較佳可以包含以重量百分比計為9.5%的伊蘭伊蘭精油，該伊蘭伊蘭精油可以取自伊蘭伊蘭（Cananga odorata ），於本實施例中，係將一伊蘭伊蘭樣品（例如，伊蘭伊蘭的花等）於60～100℃之溫度下，進行蒸餾40～120分鐘所獲得。該伊蘭伊蘭精油具有抑制壓力、催情、抗憂鬱、緩和過快心跳及降血壓等效能。The sleep-relieving essential oil composition may contain 5-15% by weight of ylang ylang essential oil (ylang ylang essential oil), and preferably may contain 9.5% by weight of ylang ylang essential oil. Ylang Ylang essential oil can be obtained from Cananga odorata . In this embodiment, a sample of Ylang Ylang (for example, the flower of Ylang Ylang, etc.) is placed at a temperature of 60-100°C. Obtained by distillation for 40 to 120 minutes. The ylang ylang essential oil has the effects of suppressing stress, aphrodisiac, anti-depression, easing excessive heartbeat and lowering blood pressure.
該舒眠精油組合物可以包含以重量百分比計為30～60%之薄荷精油（peppermint essential oil），較佳可以包含以重量百分比計為42.9%的薄荷精油，該薄荷精油可以取自歐薄荷（Mentha piperita ），於本實施例中，係將一歐薄荷樣品（例如，歐薄荷的葉等）於60～100℃之溫度下，進行蒸餾40～120分鐘所獲得。該薄荷精油具有提神醒腦、鎮痛及抗菌等效能。The sleep-relieving essential oil composition may contain 30-60% peppermint essential oil by weight percentage, preferably 42.9% by weight peppermint essential oil, and the peppermint essential oil may be obtained from peppermint ( Mentha piperita ), in this embodiment, is obtained by distilling a peppermint sample (for example, the leaves of peppermint, etc.) at a temperature of 60-100° C. for 40-120 minutes. The peppermint essential oil has refreshing, analgesic and antibacterial effects.
值得注意的是，該舒眠精油組合物係可以將前述之薰衣草精油、岩蘭草精油、苦橙葉精油、馬鬱蘭精油、伊蘭伊蘭精油及薄荷精油直接混合而成，亦可以將該狹葉薰衣草樣品、該岩蘭草樣品、該苦橙樣品、該馬鬱蘭樣品、該伊蘭伊蘭樣品及該歐薄荷樣品混合後，共同進行蒸餾所獲得，此為本發明所屬技術領域中具有通常知識者可以瞭解，於此不再贅述。It is worth noting that the sleep-relieving essential oil composition can be directly mixed with the aforementioned lavender essential oil, vetiver essential oil, petitgrain essential oil, marjoram essential oil, ylang ylang essential oil, and peppermint essential oil. It can also be prepared by directly mixing the aforementioned lavender essential oil, vetiver essential oil, petitgrain essential oil, marjoram essential oil, ylang ylang essential oil, and peppermint essential oil. The lavender sample, the vetiver sample, the bitter orange sample, the marjoram sample, the ylang ylang sample and the peppermint sample are mixed together and then distilled together. This can be obtained by those with ordinary knowledge in the technical field of the present invention. Understand, I won't repeat it here.
該舒眠精油組合物可以與至少一醫藥學上可接受之載體共同組成該改善睡眠品質的製劑，或是於該改善睡眠品質的製劑中額外添加他種具有助眠等效能之活性成分，例如可以共同形成液狀的改善睡眠品質的製劑，進而提升投予一所需個體的便利性。舉例而言，形成液狀的改善睡眠品質的製劑可以直接塗抹（或噴灑）於該所需個體的皮膚上，或者噴灑於房間中（或以擴香器使形成液狀的改善睡眠品質的製劑分布於房間中），較佳能夠於每平方公分之皮膚之表面面積上塗抹（或噴灑）0.05～0.1公克之舒眠精油組合物，或是使每立方公尺之房間中分布有0.15～0.2公克之舒眠精油組合物，使該舒眠精油組合物能夠藉由吸入性投予（nebulization administration）或經皮吸收（transdermal administration）的方式投予該所需個體。The sleep-relieving essential oil composition can be combined with at least one pharmaceutically acceptable carrier to form the preparation for improving sleep quality, or the preparation for improving sleep quality can be additionally added with other active ingredients with sleep-aiding properties, such as It can jointly form a liquid preparation for improving sleep quality, thereby improving the convenience of administering to a desired individual. For example, a liquid formulation for improving sleep quality can be directly applied (or sprayed) on the skin of the individual, or sprayed in the room (or a liquid diffuser can be used to form a liquid formulation for improving sleep quality. Distributed in the room), it is better to be able to apply (or spray) 0.05-0.1 grams of the sleep-relieving essential oil composition per square centimeter of the skin surface area, or make 0.15-0.2 per cubic meter of the room Gong Ke’s sleep-relieving essential oil composition enables the sleep-relieving essential oil composition to be administered to the desired individual by means of nebulization administration or transdermal administration.
又，該載體也可以為貼布基劑（patch base），藉此能夠共同形成貼布狀的改善睡眠品質的製劑，此時，該貼布基劑較佳可以包含樹脂等成分。舉例而言，形成貼布狀的改善睡眠品質的製劑可以貼附於該所需個體的皮膚（或穴位）上，較佳能夠使每平方公分之皮膚之表面面積上貼附有0.05～0.1公克之舒眠精油組合物，使該舒眠精油組合物能夠藉由經皮吸收（transdermal administration）的方式投予該所需個體。此外，將形成貼布狀的改善睡眠品質的製劑貼附於該所需個體的皮膚上之後，亦可以搭配穴位刺激（例如刺激印堂穴、安眠穴或太陽穴），更能夠提升其舒眠的效果。惟，前述僅為舉例而已，本發明所屬技術領域中具有通常知識者仍可以依據其使用需求調整其施用方式及施用劑量，於此不加以限定。In addition, the carrier may also be a patch base, whereby a patch-like preparation for improving sleep quality can be formed together. In this case, the patch base may preferably contain components such as resin. For example, a patch-shaped preparation for improving sleep quality can be attached to the skin (or acupuncture point) of the desired individual, preferably capable of attaching 0.05 to 0.1 grams per square centimeter of the skin surface area The sleep-relieving essential oil composition enables the sleep-relieving essential oil composition to be administered to the desired individual by means of transdermal administration. In addition, after attaching a patch-shaped preparation for improving sleep quality to the skin of the individual, it can also be combined with acupoint stimulation (such as stimulating Yintang, Anmian, or Temple) to improve its sleep-relieving effect. . However, the foregoing is only an example, and those with ordinary knowledge in the technical field of the present invention can still adjust the application method and dosage according to their use requirements, which is not limited here.
為證實本發明之舒眠精油組合物確實具有優於薰衣草精油的改善睡眠品質的效果，遂使第A1組的使用者使用形成貼布狀的本發明之舒眠精油組合物，測試使用者的入睡前的等待時間及熟睡狀況，依使用者自我評估的結果顯示，第A1組的使用者僅需約10～15分鐘的時間即能夠入睡，而熟睡狀況可以長達8～12小時。另使第A0組的使用者使用形成貼布狀的單方薰衣草精油，依使用者自我評估的結果顯示，第A0組的使用者約需20～30分鐘的時間才能夠入睡，而熟睡狀況則僅只有1～2小時。In order to verify that the sleep-relieving essential oil composition of the present invention does have better sleep quality improvement effects than lavender essential oil, users in group A1 were asked to use the sleep-relieving essential oil composition of the present invention formed into a patch to test the user’s According to the self-assessment results of the user’s self-assessment of the waiting time before going to bed and the state of deep sleep, users in group A1 only need about 10-15 minutes to fall asleep, while the state of deep sleep can be as long as 8-12 hours. In addition, users in group A0 were asked to use a patch-like unilateral lavender essential oil. According to the user’s self-assessment results, it took about 20-30 minutes for users in group A0 to fall asleep. Only 1 to 2 hours.
依據上述實驗結果，顯示本發明之舒眠精油組合物確實具有優於單方薰衣草精油的改善睡眠品質的效果。Based on the above experimental results, it is shown that the sleep-relieving essential oil composition of the present invention does have better sleep quality improvement effects than single lavender essential oil.
綜合上述，本發明之舒眠精油組合物，藉由該薰衣草精油、該岩蘭草精油、該苦橙葉精油、該馬鬱蘭精油、該伊蘭伊蘭精油及該薄荷精油的加乘作用，有助於安定精神、抑制壓力、促進睡眠，使該舒眠精油組合物可以應用於製備改善睡眠品質的製劑，且其改善睡眠品質的效果顯著優於單方薰衣草精油，為本發明之功效。In summary, the sleep-relieving essential oil composition of the present invention, through the additive effect of the lavender essential oil, the vetiver essential oil, the petitgrain essential oil, the marjoram essential oil, the ylang ylang essential oil, and the peppermint essential oil, helps In order to stabilize the spirit, inhibit stress, and promote sleep, the sleep-relieving essential oil composition can be used to prepare preparations for improving sleep quality, and its effect of improving sleep quality is significantly better than that of single lavender essential oil, which is the effect of the present invention.
又，該舒眠精油組合物的用途係藉由該薰衣草精油、該岩蘭草精油、該苦橙葉精油、該馬鬱蘭精油、該伊蘭伊蘭精油及該薄荷精油的加乘作用，可以用於改善該所需個體的睡眠品質，並可以減少失眠症等的睡眠障礙的發生，減少該所需個體由於睡眠品質不佳所導致的精神不佳、易怒、抑鬱等症狀，更可以提升該所需個體的注意力及工作、學習效果，為本發明之功效。In addition, the use of the sleep-relieving essential oil composition is based on the additive effect of the lavender essential oil, the vetiver essential oil, the petitgrain essential oil, the marjoram essential oil, the ylang ylang essential oil, and the peppermint essential oil. It can improve the sleep quality of the individual in need, and can reduce the occurrence of sleep disorders such as insomnia, and reduce the symptoms of poor mentality, irritability, depression and other symptoms of the individual in need due to poor sleep quality, and can also improve the institution. It requires the individual's attention and the effect of work and study, which is the effect of the present invention.
此外，由於該舒眠精油組合物的高滲透分子能夠經由皮脂腺或皮脂膜吸收，並經由血管及淋巴管快速循環至各組織器官，可以避免口服投予可能發生的肝首過效應，更可以延長作用時間並減少投予次數，進而能夠達成提升治療效果、減少副作用發生的可能性，及增加該所需個體的用藥順從性等功效。In addition, because the high-permeability molecules of the sleep-relieving essential oil composition can be absorbed through the sebaceous glands or sebaceous membranes, and quickly circulate to various tissues and organs through blood vessels and lymphatics, the possible first-pass effect of the liver can be avoided by oral administration, and the effect can be prolonged. The action time and the reduction of the number of administrations can achieve the effects of improving the therapeutic effect, reducing the possibility of side effects, and increasing the medication compliance of the required individual.
雖然本發明已利用上述較佳實施例揭示，然其並非用以限定本發明，任何熟習此技藝者在不脫離本發明之精神和範圍之內，相對上述實施例進行各種更動與修改仍屬本發明所保護之技術範疇，因此本發明之保護範圍當視後附之申請專利範圍所界定者為準。Although the present invention has been disclosed using the above-mentioned preferred embodiments, it is not intended to limit the present invention. Anyone who is familiar with the art without departing from the spirit and scope of the present invention may make various changes and modifications relative to the above-mentioned embodiments. The technical scope of the invention is protected. Therefore, the scope of protection of the invention shall be subject to the scope of the attached patent application.
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