TW201920668A - 核酸複合體 - Google Patents

核酸複合體 Download PDF

Info

Publication number: TW201920668A
Authority: TW; Taiwan
Prior art keywords: compound; nucleic acid; reference example; mmol; equation
Prior art date: 2017-08-02

Application number

TW107126968A

Other languages

English (en)

Chinese (zh)

Inventor

山田陽史

岩井宏徒

上原啓嗣

鈴木康裕

福田裕一

木內達人

Original Assignee

日商協和醱酵麒麟有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-08-02

Filing date

2018-08-02

Publication date

2019-06-01

2018-08-02 Application filed by 日商協和醱酵麒麟有限公司 filed Critical 日商協和醱酵麒麟有限公司

2019-06-01 Publication of TW201920668A publication Critical patent/TW201920668A/zh

Links

108020004707 nucleic acids Proteins 0.000 title claims abstract description 273
102000039446 nucleic acids Human genes 0.000 title claims abstract description 273
150000007523 nucleic acids Chemical class 0.000 title claims abstract description 272
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235000000346 sugar Nutrition 0.000 claims abstract description 69
230000000692 anti-sense effect Effects 0.000 claims abstract description 58
108020004999 messenger RNA Proteins 0.000 claims abstract description 52
239000002773 nucleotide Substances 0.000 claims abstract description 48
239000003446 ligand Substances 0.000 claims abstract description 36
230000000295 complement effect Effects 0.000 claims abstract description 35
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108091081021 Sense strand Proteins 0.000 claims abstract description 24
238000000034 method Methods 0.000 claims description 197
125000004432 carbon atom Chemical group C* 0.000 claims description 33
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
201000010099 disease Diseases 0.000 claims description 30
108090000623 proteins and genes Proteins 0.000 claims description 27
239000003814 drug Substances 0.000 claims description 21
239000008194 pharmaceutical composition Substances 0.000 claims description 20
125000005647 linker group Chemical group 0.000 claims description 12
241000124008 Mammalia Species 0.000 claims description 7
230000002401 inhibitory effect Effects 0.000 claims description 6
238000001990 intravenous administration Methods 0.000 claims description 4
238000007920 subcutaneous administration Methods 0.000 claims description 4
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239000000126 substance Substances 0.000 description 143
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108020004414 DNA Proteins 0.000 description 10
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BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 10
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
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Organic Chemistry (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
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Biotechnology (AREA)
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Endocrinology (AREA)
Reproductive Health (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW107126968A 2017-08-02 2018-08-02 核酸複合體 TW201920668A (zh)

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EP3888663A1 (en) *	2018-11-30	2021-10-06	Kyowa Kirin Co., Ltd.	Nucleic acid complex
JP7636333B2 (ja)	2019-09-10	2025-02-26	第一三共株式会社	肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法

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WO2009082607A2 (en) *	2007-12-04	2009-07-02	Alnylam Pharmaceuticals, Inc.	Targeting lipids
AU2012340159B2 (en) *	2011-11-18	2017-09-07	Alnylam Pharmaceuticals, Inc.	RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
BR112015027322A8 (pt) *	2013-05-01	2018-01-02	Isis Pharmaceuticals Inc	Compostos antissenso conjugados e sua utilização
EP4039278A1 (en) *	2013-07-11	2022-08-10	Alnylam Pharmaceuticals, Inc.	Oligonucleotide-ligand conjugates and process for their preparation
WO2015105083A1 (ja) *	2014-01-07	2015-07-16	塩野義製薬株式会社	アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド
JP2018150239A (ja) *	2015-07-15	2018-09-27	協和発酵キリン株式会社	β２ＧＰＩ遺伝子発現抑制ＲＮＡｉ医薬組成物
EP3323893A4 (en) *	2015-07-16	2019-03-27	Kyowa Hakko Kirin Co., Ltd.	BETA2GPI GENE EXPRESSION-INHIBITING NUCLEIC ACID COMPLEX
EP3409780B1 (en) *	2016-01-29	2021-01-20	Kyowa Kirin Co., Ltd.	Nucleic acid complex
US12251446B2 (en) *	2016-06-30	2025-03-18	Kyowa Kirin Co., Ltd.	Nucleic acid conjugate

2018
- 2018-08-02 WO PCT/JP2018/029079 patent/WO2019027009A1/ja not_active Ceased
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Also Published As

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WO2019027009A1 (ja)	2019-02-07

Publication	Publication Date	Title
JP6853193B2 (ja)	2021-03-31	核酸複合体
AU2018394875B2 (en)	2023-08-03	Conjugates and preparation and use thereof
TW201909925A (zh)	2019-03-16	核酸複合體
CA2917161C (en)	2023-12-12	Oligonucleotide-ligand conjugates and process for their preparation
CN109415401B (zh)	2023-02-03	核酸复合物
JPWO2017010575A1 (ja)	2018-04-26	β２ＧＰＩ遺伝子発現抑制核酸複合体
EP3888663A1 (en)	2021-10-06	Nucleic acid complex
TW201920668A (zh)	2019-06-01	核酸複合體
JP2019024444A (ja)	2019-02-21	核酸複合体
JP2024528270A (ja)	2024-07-26	治療活性剤の送達のためのリガンド共役体
HK40059056A (en)	2022-04-29	Nucleic acid complex
TW202142260A (zh)	2021-11-16	核酸複合體及包含其之醫藥組合物
CA3029508C (en)	2025-09-09	Nucleic acid conjugate