[go: up one dir, main page]

TW201801723A - 瑞米司他在亞洲患者中之醫療應用 - Google Patents

瑞米司他在亞洲患者中之醫療應用 Download PDF

Info

Publication number
TW201801723A
TW201801723A TW106112466A TW106112466A TW201801723A TW 201801723 A TW201801723 A TW 201801723A TW 106112466 A TW106112466 A TW 106112466A TW 106112466 A TW106112466 A TW 106112466A TW 201801723 A TW201801723 A TW 201801723A
Authority
TW
Taiwan
Prior art keywords
remistat
human subject
salt
sorafenib
cancer
Prior art date
Application number
TW106112466A
Other languages
English (en)
Chinese (zh)
Inventor
曼弗瑞 葛羅沛
Original Assignee
4Sc製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc製藥公司 filed Critical 4Sc製藥公司
Publication of TW201801723A publication Critical patent/TW201801723A/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW106112466A 2016-04-14 2017-04-14 瑞米司他在亞洲患者中之醫療應用 TW201801723A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
??16165258.1 2016-04-14
EP16165258 2016-04-14

Publications (1)

Publication Number Publication Date
TW201801723A true TW201801723A (zh) 2018-01-16

Family

ID=55754183

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106112466A TW201801723A (zh) 2016-04-14 2017-04-14 瑞米司他在亞洲患者中之醫療應用

Country Status (5)

Country Link
JP (1) JP2019511544A (fr)
KR (1) KR20180130565A (fr)
CN (1) CN109069647A (fr)
TW (1) TW201801723A (fr)
WO (1) WO2017178577A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113795260A (zh) 2019-08-20 2021-12-14 宫本有正 屁和/或大便的恶臭减少剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005087724A2 (fr) 2004-03-11 2005-09-22 Altana Pharma Ag Nouvelles hydroxy-6-phenylphenanthridines a substitution amido
BRPI0617167B8 (pt) 2005-09-21 2021-05-25 Nycomed Gmbh sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação
EP2100878A1 (fr) 2008-03-12 2009-09-16 4Sc Ag Nouveau procédé pour la production de sulphonylpyrroles en tant qu'inhibiteurs HDAC

Also Published As

Publication number Publication date
JP2019511544A (ja) 2019-04-25
WO2017178577A1 (fr) 2017-10-19
CN109069647A (zh) 2018-12-21
KR20180130565A (ko) 2018-12-07

Similar Documents

Publication Publication Date Title
US20250289794A1 (en) Compounds and methods for treating cancer
JP2021020957A (ja) 二官能性分子によって標的化タンパク質分解を誘導する方法
Sorrentino et al. Therapeutic targeting of notch signaling pathway in hematological malignancies
Yi et al. Triptolide induces cell killing in multidrug-resistant tumor cells via CDK7/RPB1 rather than XPB or p44
EP2818170B1 (fr) N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridine yl) oxy)phényl)-4-(4-méthyl-2-thiényl)-1-phthalazinamine à utiliser dans le traitement d'un cancer résistant aux agents antimitotiques
CN108101890A (zh) N-磺酰基吡咯衍生物
WO2006009765A2 (fr) Procedes d'identification et d'utilisation de composes adaptes au traitement de cellules cancereuses resistantes aux medicaments
TW200409775A (en) Novel pyrazolopyridines as cyclin dependent kinase inhibitors
Lu et al. Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma
Li et al. Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC
WO2021144302A1 (fr) Biomarqueurs pour déterminer la sensibilité à des dérivés d'oxopipérazine et leurs méthodes d'utilisation
CN114173878A (zh) 拟肽大环化合物及其用途
TW201801723A (zh) 瑞米司他在亞洲患者中之醫療應用
Li et al. A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle
US8987286B2 (en) Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway
CN120513097A (zh) 订书钉化肽及其方法
HK40002141A (zh) 瑞米司他(resminostat)在亚洲患者中的医疗应用
WO2018053472A1 (fr) Composition et méthodes de ciblage de cellules souches cancéreuses
US20220257592A1 (en) Methods of treating cancer
US20200016118A1 (en) Hdac inhibitor in combination with vegf/vegfr interaction for cancer therapy based on platelet count
Krauss et al. Hdac inhibitor in combination with vegf/vegfr interaction for cancer therapy based on platelet count
EP2279193A1 (fr) Nouveaux dérivés de triazole, leur préparation et leur application en thérapeutique
WO2025193649A1 (fr) Utilisation d'un agent de dégradation du p300/cbp utilisée pour le traitement du cancer
HK40069081A (en) Methods of treating cancer
CN117982498A (zh) 一种含蛋白降解剂或抑制剂的组合物及其用途