TW201718876A - Methods for making diagnosis and/or prognosis of neoplasm - Google Patents

Abstract

Disclosed herein are various methods for assessing the presence of gynecologic neoplasm or the malignancy of the gynecologic neoplasm, based on the hypermethylation of one or more marker genes.

Description

Method for diagnosing and pre-diagnosing tumors

The present disclosure relates to the diagnosis and prognosis of cancer. In particular, the present disclosure is a method for performing cancer diagnosis and prognosis evaluation based on the methylation status of a particular gene signature.

Gynecological cancer refers to the uncontrolled growth of abnormal cells that originate in the female reproductive organs. The main types of gynecological cancer include cervical cancer, ovarian cancer, endometrial cancer/uterine cancer (hereinafter referred to as endometrial cancer), vaginal cancer and vaginal cancer; in addition, gestational trophoblastic disease (GTD) It is a rare gynecological cancer with primary peritoneal cancer.

According to the Centers for Disease Control and Prevention (CDC), approximately 71,500 women in the United States are diagnosed with gynecological cancer each year.

Endometrial cancer is the leading gynaecological cancer in the United States, with approximately 35,000 confirmed cases each year. Most patients with endometrial cancer are menopausal women. However, for patients who have not yet shown symptoms, there is currently no convenient and reliable method of detection. For women with a higher risk of symptoms or illness, endometrial spleen or vaginal ultrasound can be collected to diagnose or rule out endometrial cancer.

Ovarian cancer is a common gynecological cancer after endometrial cancer, but its mortality rate is the highest among gynecological cancers. The symptoms of ovarian cancer are usually not obvious at an early stage, so fewer cases of ovarian cancer are diagnosed early. At the time of diagnosis, it is usually more advanced, and the tumor often spreads out of the ovary. Specifically, approximately 90% of ovarian cancer cases are derived from epithelial cells, and up to 70% of epithelial ovarian cancer cases are diagnosed in Phase III or Phase IV.

The early cure rate for ovarian cancer is extremely high; for women diagnosed with stage I ovarian cancer, the 10-year survival rate is close to 90%. In comparison, the five-year or fourth-stage patients have a five-year survival rate of only 15%-20%. Therefore, the ability to diagnose ovarian cancer early will be of great help. Current methods for screening for ovarian cancer include: BRCA genetic testing, vaginal ultrasound, and serum cancer antigen (CA)-125 detection. However, BRCA genetic testing is primarily used to assess prognosis. On the other hand, vaginal ultrasound and CA-125 detect false positives (about 10%), which often leads to unnecessary ovarian removal surgery. For this reason, in 2012, the Preventive Service Task Force recommended not to screen for ovarian cancer such as CA-125 and vaginal ultrasound for asymptomatic, low-risk women because of these screenings. The harm may be higher than the benefits.

In view of this, there is a need in the related art to propose a method for diagnosing gynecological tumors.

SUMMARY OF THE INVENTION The Summary of the Disclosure is intended to provide a basic understanding of the present disclosure. This Summary is not an extensive overview of the disclosure, and is not intended to be an

A first aspect of the invention relates to a method for assessing whether a subject has a benign or malignant gynecological tumor.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein the at least one target gene is selected from the group consisting of The following groups: ADAMTS16 (sequence number: 1), APBB1IP (sequence number: 4), CBLN4 (sequence number: 7), CCDC140 (sequence number: 10), CELF4 (sequence number: 11), CNTNAP5 (sequence No.: 14), EFS (sequence number: 17), EMILIN1 (sequence number: 18), FERD3L (sequence number: 23), FEZF2 (sequence number: 24), GALNTL6 (sequence number: 28), GRIA4 (sequence number: 30), NEFL (sequence number: 44), PARP15 (sequence number: 49), PAX6 (sequence number: 50), PRLHR (sequence number: 56), SSTR1 (sequence number: 64), ST8SIA5 (sequence number: 65) , VWC2 (sequence number: 73), ZNF300 (sequence number: 77), ZNF334 (sequence number: 78), ZNF662 (sequence number: 79), CCDC105 (sequence number: 9), CYP26C1 (sequence number: 16), HORMAD2 (sequence number: 32), IFFO1 (sequence number: 33), LOC100130872 ( Sequence number: 39), NKAPL (sequence number: 45), PCDHGA11 (sequence number: 52), SLC25A2 (sequence number: 63), TCTEX1D1 (sequence number: 68), TMEM101 (sequence number: 70), TRIM61 (sequence number) :71), WDR69 (sequence number: 74), AOX1 (sequence number: 2), CACNA2D4 (sequence number: 6), COL6A3 (sequence number: 81), CPEB1 (sequence number: 82), FAM101A (sequence number: 19) ), FAM115A (sequence number: 20), FBXL22 (sequence number: 22), FIGLA (sequence number: 25), FLJ32255 (sequence number: 26), FOXB2 (sequence number: 27), GIGYF1 (sequence number: 29), GSX1 (sequence number: 21), KIAA1731NL (sequence number: 34), LBX2 (sequence number: 35), LINC00925 (sequence number: 36), LINC01210 (sequence number: 37), LINC01475 (sequence number: 38), LOC283692 ( SEQ ID NO: 40), LOC440982 (sequence number: 41), MIR124-2HG (sequence number: 42), MKX (sequence number: 43), NRN1 (sequence number: 47), PFN3 (sequence number: 53), PHOX2A ( Sequence number: 54), PIP4K2A (sequence number: 55), PYGO1 (sequence number: 57), SKOR1 ( Sequence number: 61), SKOR2 (sequence number: 62), TBX15 (sequence number: 66), TBX5-AS1 (sequence number: 67), UCKL1 (sequence number: 72), WDR86 (sequence number: 75), ZDHHC19 ( SEQ ID NO: 76), APBA1 (sequence number: 3), CACNA1A (sequence number: 5), CBS (sequence number: 8), CIDEB (sequence number: 12), CKB (sequence number: 13), COLQ (sequence number) :15), FAM49B (sequence number: 21), NR5A2 (sequence number: 46), OSBPL2 (sequence number: 48), PCDH17 (sequence number: 51), RYK (sequence number: 58), SDPR (sequence number: 59) ), SKIL (SEQ ID NO: 60), TEAD1 (SEQ ID NO: 69), and ZNF669 (SEQ ID NO: 80); (c) determining whether the at least one target gene is highly methylated; and (d) based on step (c) The results assess whether the individual has a gynecological tumor, wherein a high degree of methylation of at least one target gene represents the individual's gynecological tumor.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of ADAMTS16, APBB1IP, CBLN4, CCDC140, CELF4, CNTNAP5, EMILIN1, FERD3L, FEZF2, GALNTL6, GRIA4, NEFL, PAX6 , PRLHR, SSTR1, ST8SIA5, VWC2, ZNF300, ZNF334, ZNF662, CCDC105, CYP26C1, HORMAD2, IFFO1, LOC100130872, NKAPL, PCDHGA11, SLC25A2, TCTEX1D1, TMEM101, TRIM61 and WDR69.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of AOX1, CACNA2D4, CBLN4, CCDC140, CYP26C1, EMILIN1, FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2, GIGYF1 , GSX1, KIAA1731NL, LBX2, LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, NRN1, PCDHGA11, PFN3, PHOX2A, PIP4K2A, PRLHR, PYGO1, SKOR1, SKOR2, TBX5-AS1, UCKL1, WDR86, ZDHHC19 , APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669.

According to various embodiments of the present disclosure, the sample is a sample taken from a body (preferably a human body) or a sample originally present in an individual (preferably a human body); the sample includes tissue, tissue sample or Cell samples (eg, tissue sections, eg, aspiration biopsy, brush biopsy, surface biopsy, needle biopsy, punch biopsy, resectable Excision biopsy, open biopsy, incision biopsy, endoscopic biopsy, cervical scraping cells, uterus scraping cells Or vaginal lavage, tumor, tumor sample or biological fluid (eg, peritoneal fluid, blood (containing plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from an individual's ovarian tissue, a cell sample (eg, a cervical scraping cell), and a body fluid (eg, serum and plasma).

A second aspect of the invention relates to a method for assessing whether a subject has malignant endometrial cancer.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein the at least one target gene is selected from the group consisting of The following groups: ADAMTS16, APBB1IP, CBLN4, CCDC140, CELF4, CNTNAP5, EFS, EMILIN1, FERD3L, FEZF2, GALNTL6, GRIA4, NEFL, PARP15, PAX6, PRLHR, SSTR1, ST8SIA5, VWC2, ZNF300, ZNF334, ZNF662 , CCDC105, CYP26C1, HORMAD2, IFFO1, LOC100130872, NKAPL, PCDHGA11, SLC25A2, TCTEX1D1, TMEM101, TRIM61 and WDR69; (c) determining whether the at least one target gene is highly methylated; and (d) based on step (c) As a result, it was evaluated whether the individual had malignant endometrial cancer, and at least one target gene was highly methylated to represent the individual suffering from malignant endometrial cancer.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of APBB1IP, CELF4, EFS, FEZF2, GRIA4, NEFL, PAX6, FERD3L, SSTR1, ZNF300, ZNF334, and ZNF662.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of CELF4, FERD3L, FEZF2, EFS, PARP15, ZNF300, ZNF334, and ZNF662.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of ZNF300, ZNF334, and ZNF662.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of EFS, FEZF2, and ZNF300.

According to some embodiments of the present disclosure, in step (b), the methylation status of two or three target genes in EFS, FEZF2 and ZNF300 is determined.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of CELF4, EFS, ZNF334, and ZNF662.

According to certain embodiments of the present disclosure, in step (b), the methylation status of two, three or all of the target genes in CELF4, EFS, ZNF334 and ZNF662 is determined.

According to various embodiments of the present disclosure, the sample is a sample taken from a body (preferably a human body) or a sample originally present in an individual (preferably a human body); the sample includes tissue, tissue sample or Cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excision, open, incision, endoscopic, cervical scraping , uterus scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (including plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from an individual's ovarian tissue, a cell sample (eg, a cervical scraping cell), and a body fluid (eg, serum and plasma).

A third aspect of the present disclosure relates to a method for assessing whether a subject has an ovarian tumor.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein at least one target gene is selected from the group consisting of Groups composed: AOX1, CACNA2D4, CBLN4, CCDC140, COL6A3, CPEB1, CYP26C1, EMILIN1, FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2, GIGYF1, GSX1, KIAA1731NL, LBX2, LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, NRN1, PCDHGA11, PFN3, PHOX2A, PIP4K2A, PRLHR, PYGO1, SKOR1, SKOR2, TBX15, TBX5-AS1, UCKL1, WDR86, ZDHHC19, APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669; (c) determining whether the at least one target gene is highly methylated; and (d) evaluating whether the individual has an ovary based on the result of step (c) A tumor in which at least one target gene is highly methylated represents an individual suffering from an ovarian tumor.

According to some embodiments of the present disclosure, the hypermethylation of the at least one target gene represents that the ovarian tumor is malignant, and wherein at least one target gene is selected from the group consisting of AOX1, CACNA2D4, CBLN4, CCDC140 , COL6A3, CPEB1, CYP26C1, EMILIN1, FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2, GIGYF1, GSX1, KIAA1731NL, LBX2, LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, PCDHGA11, PFN3, PHOX2A , PIP4K2A, PRLHR, PYGO1, SKOR1, SKOR2, TBX5-AS1, UCKL1, WDR86, ZDHHC19, APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669 .

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of AOX1, FAM115A, NRN1, PCDHGA11, PHOX2A, PYGO1, TBX15, UCKL1, and WDR86.

According to some embodiments of the present disclosure, the at least one target gene is NRN1, TBX15 or both.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of FEZF2, PAX6, and ZNF662.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of AOX1, CACNA2D4, COL6A3, CPEB1, FAM115A, NRN1, TBX15, PCDHGA11, PHOX2A, UCKL1, and WDR86.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of NRN1, AOX1, TBX15, and COL6A3.

According to various embodiments of the present disclosure, the sample is a sample taken from a body (preferably a human body) or a sample originally present in an individual (preferably a human body); the sample includes tissue, tissue sample or Cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excision, open, incision, endoscopic, cervical scraping , uterus scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (including plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from an individual's ovarian tissue, a cell sample (eg, a cervical scraping cell), and a body fluid (eg, serum and plasma).

A fourth aspect of the invention relates to a method for assessing whether a subject has an ovarian tumor and its degree of malignancy. According to an embodiment of the present invention, the method comprises the steps of: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein at least one target gene is selected from the following a group consisting of: NRN1, AOX1, TBX15, COL6A3, and WDR86; (c) determining whether the at least one target gene is highly methylated; and (d) evaluating whether the individual has an ovarian tumor based on the result of step (c) The degree of malignancy in which at least one target gene is highly methylated represents that the individual has an ovarian tumor, and a hypermethylation of AOX1, WDR86, or both indicates that the ovarian tumor is malignant.

According to various embodiments of the present disclosure, the sample is a sample taken from a body (preferably a human body) or a sample originally present in an individual (preferably a human body); the sample includes tissue, tissue sample or Cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excision, open, incision, endoscopic, cervical scraping , uterus scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (including plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from an individual's ovarian tissue, a cell sample (eg, a cervical scraping cell), and a body fluid (eg, serum and plasma).

In an embodiment that is carried out as needed, the step of determining the methylation status of the gene described in any aspect/embodiment of the present disclosure may be performed by the following technique: methylation specificity polymerase chain reaction (methylation- Specific polymerase chain reaction; MSP), quantitative methylation-specific polymerase chain reaction (qMSP), sulfite sequencing (BS), sulfite pyrophosphate sequencing ( Bisulfite pyrosequencing), microarrays, mass spectrometry, denaturing high-performance liquid chromatography (DHPLC), pyrosequencing, methylated DNA immunoprecipitation Methylated DNA immunoprecipitation (MeDIP or mDIP) coupled with quantitative polymerase chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing (nanopore sequencing).

A fifth aspect of the present disclosure relates to a method for assessing whether a body has a colon tumor.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein at least one target gene is selected from the group consisting of a group consisting of: PAX6, TBX15, and ZNF334; (c) determining whether the at least one target gene is highly methylated; and (d) evaluating whether the individual has a colon tumor based on the result of step (c), wherein at least one target High methylation of the gene indicates that the individual has a colon tumor.

According to various embodiments of the present disclosure, the sample is a sample taken from a body (preferably a human body) or a sample originally present in an individual (preferably a human body); the sample includes tissue, tissue sample or Cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excision, open, incision, endoscopic, cervical scraping , uterus scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (including plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from an individual's ovarian tissue, a cell sample (eg, a cervical scraping cell), and a body fluid (eg, serum and plasma).

In an embodiment that is carried out as needed, the following steps can be performed to determine the methylation status of the gene as described in any aspect/embodiment of the present disclosure: methylation specificity polymerase chain reaction (MSP) , quantitative methylation specificity polymerase chain reaction (qMSP), sulfite sequencing (BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), coke Phosphoryl sequencing, methylated DNA immunoprecipitation and quantitative polymerase chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing.

The basic spirit and other objects of the present invention, as well as the technical means and implementations of the present invention, will be readily apparent to those skilled in the art of the invention.

The description of the embodiments of the present invention is intended to be illustrative and not restrictive. The features of various specific embodiments, as well as the method steps and sequences thereof, are constructed and manipulated in the embodiments. However, other specific embodiments may be utilized to achieve the same or equivalent function and sequence of steps.

The scientific and technical terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the invention pertains, unless otherwise defined herein.

In addition, the singular noun used in this specification covers the plural of the noun in the case of no conflict with the context; the plural noun of the noun is also included in the plural noun used. In particular, the singular <RTI ID=0.0>" </ RTI> </ RTI> <RTIgt; In addition, in the scope of the present specification and the patent application, the expressions "at least one" and "one or more" have the same meaning, and both represent one, two, three or more. What is more, in the scope of this specification and the patent application, "at least one of A, B and C", "at least one of A, B or C" and at least one of "A, B and / or C" It refers to only A, only B, only C, A and B, B and C, A and C, and A, B and C.

Although numerical ranges and parameters are used to define a broad range of values for the present invention, the relevant values in the specific embodiments have been presented as precisely as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. As used herein, "about" generally means that the actual value is within plus or minus 10%, 5%, 1%, or 0.5% of a particular value or range. Alternatively, the term "about" means that the actual value falls within the acceptable standard error of the average, depending on the considerations of those of ordinary skill in the art to which the invention pertains. Except for the experimental examples, or unless otherwise explicitly stated, all ranges, quantities, values, and percentages used herein are understood (eg, to describe the amount of material used, the length of time, the temperature, the operating conditions, the quantity ratio, and the like. Are all modified by "about". Therefore, unless otherwise indicated to the contrary, the numerical parameters disclosed in the specification and the appended claims are intended to be At a minimum, these numerical parameters should be understood as the number of significant digits indicated and the values obtained by applying the general carry method. Ranges of values are expressed herein as being from one endpoint to another or between two endpoints; unless otherwise stated, the numerical ranges recited herein are inclusive.

In the present disclosure, the term "assessing" refers to the process of determining the health of a body. The health status of an individual can refer to a diagnosis, prognosis, or a higher risk of gynecological tumor rickets to the individual.

The term "diagnosis" as used herein refers to the identification of pathological conditions, diseases or symptoms, such as tumors of different gynecological origin, including the cervix, ovary, endometrium/uterus, vagina, vulva, uterus and lining. The peritoneum of the uterus. In some instances, the term "diagnosis" refers to the identification of malignant and benign tumors. In other instances, the term diagnostic refers to the identification of malignant tumors and normal tissues.

The term "prognosis" refers to predicting the death or cancer progression caused by cancer, including: recurrence rate and metastatic spread of a neoplastic disease, and recurrence-free survival of tumor patients. Recurrence-free survival time, progression-free time, or overall survival time. According to a particular embodiment of the present disclosure, the "prognosis" refers to recurrence-free survival (RFS), progression-free survival (PFS), or overall survival (overall survival; OS). Furthermore, the term "poor prognosis" refers to an individual whose expected prognosis for a poor prognosis is significantly lower than the methylation of one or more target genes. In other embodiments, an individual's "RFS poor" means that the individual's RFS period is less than 12 or 24 months. Similarly, "poor overall survival" or "poor progression without disease progression" means that the individual has less than 12 or 24 months of OS or PFS. Alternatively, poor RFS or PFS may mean that the probability of recurrence or worsening of an individual with a poor RFS or PFS is higher in a particular period than in a control individual.

In the present disclosure, the term "tumor, neoplasm or neoplasm" refers to abnormally new cells or abnormally growing cells that grow faster than normal cells. Tumors produce benign or malignant unstructured masses (lumps). The term "benign" refers to a non-cancerous tumor or tumor, for example, cells do not invade surrounding tissues or metastasize to distant places; and "malignant" refers to metastatic tumors or tumors that can invade surrounding tissues. And is not controlled by normal cell growth.

As used herein, the term "cancer" refers to all types of cancer or malignant tumor or tumor in an animal. In accordance with various embodiments of the present disclosure, the methods disclosed herein are directed to the diagnosis and/or prognosis of one or more malignancies derived from gynecological organs/tissues. The term "carcinoma" refers to a malignant tumor or cancer derived from epithelial cells. For example, gynecological cancers as shown in various embodiments of the present disclosure include, but are not limited to, ovarian cancer, cervical cancer, endometrial cancer, vaginal cancer, genital cancer, and primary peritoneal cancer.

When the C5 position of the cytosine in the CpG dinucleotide located in the core promoter region of the gene is covalently bonded to the methyl group, it is called "methylation". The "methylation state" refers to the presence or absence of 5-methyl-cytosine (5-mCyt) on one or more CpG dinucleotides within a gene or a nucleic acid sequence of interest. As used herein, "methylation level" refers to the amount of methylation in one or more copies of a gene or nucleic acid sequence. The degree of methylation of the gene or nucleic acid sequence of interest can be expressed as an absolute value. Furthermore, the concept of "relative methylation level" can also be used, in which the amount of methylated DNA is expressed relative to the total amount of DNA, or a copy of a gene or nucleic acid sequence indicating methylation. The number of copies relative to the total number of copies of the gene or nucleic acid sequence. In addition, "methylation level" refers to the percentage of methylated CpG sites in the DNA fragment of interest.

As used herein, "methylation profile" refers to a set of data on the degree of methylation of one or more target genes in a sample. In certain embodiments, the methylation profile is a map compared to a methylated reference map taken from an unknown type of sample, such as a cancerous sample or a non-cancerous sample or a different cancer stage Sample.

Here, "differential methylation" refers to the degree of methylation of one or more target genes in a sample or population and the degree of methylation of one or more target genes in other samples or populations. There are differences. Differential methylation can be distinguished by an increased degree of methylation (hypermethylation) or a decrease in the degree of methylation (hypomethylation). Here, "highly methylated" means that the degree of methylation of the target gene in the test sample is increased by at least 10% compared to the average methylation degree of the target gene in the reference sample. According to various embodiments of the present disclosure, the increased degree of methylation means an increase of at least 15, 20, 25, 30, 35, 40, 45 or 50%.

When conceivably, all of the genes or polynucleotide sequences described in the present disclosure each comprise variants thereof which have at least 75% nucleotide sequence similarity to the gene or polynucleotide sequence. Furthermore, the gene or polynucleotide sequence of the present disclosure may be replaced by the term "polynucleotide having at least 75% nucleotide sequence similarity", unless otherwise indicated. Thus, unless otherwise stated to the contrary, a gene or polynucleotide sequence as described herein is understood to encompass "the sulfite conversion sequence thereof and at least 75% of the nucleosides associated with the gene or the sulfite conversion sequence. A polynucleotide sequence of acid sequence similarity".

The "percent (%) sequence identity" as used herein for a nucleotide sequence means that the nucleotide residue of a candidate sequence is identical to the nucleotide residue of a reference polynucleotide sequence. Percentage. When performing the above alignment, the candidate sequence may be side by side with the reference polynucleotide sequence, and a gap may be introduced as necessary to form the highest sequence similarity of the two sequences, and when calculating the similarity, Conservative substitutions are considered to be the same nucleotide. A variety of methods are available for the above-described side-by-side, such as publicly available software such as BLAST, BLAST-2, ALIGN or Megalign (DNASTAR). Those skilled in the art to which the present invention pertains may select appropriate parameters and calculation methods when performing side-by-side to obtain an optimal arrangement. The nucleotide sequence similarity of a candidate polynucleotide sequence A compared to a reference polynucleotide sequence B (also referred to herein as sequence A and sequence B have a specific percentage (%) of nucleotide sequence similarity Degree) is calculated as follows: % where X is the identical nucleotide match obtained by arranging sequences A and B using the Blastp or Blastn analysis database, and Y is the shorter nucleotide of the A and B sequences. The total number of residues.

In the present specification, the words "individual" or "patient" are used interchangeably and refer to an animal, including a human, which can be diagnosed and/or prognosed by the method of the present invention. Thus, an "individual" or "patient" includes any mammal that can benefit from the treatment of this disclosure. Examples of such "individual" or "patient" include, but are not limited to, humans, rats, mice, guinea pigs, monkeys, pigs, goats, cows, horses, dogs, cats, birds, and birds. In an example, the patient is a human. The mammals encompass all members of the mammalian class, including humans, primates, livestock and farm animals (such as rabbits, pigs, sheep and cattle), zoo or competition animals, pets, and rodents (eg, Mouse and rat). The term "non-human mammals" covers all mammalian members except humans.

The term "sample" as used herein includes any sample taken from an individual or patient. In accordance with the methods of the present disclosure, the sample comprises a DNA molecule that is capable of determining the degree of methylation. For example, the sample taken from an individual or a patient includes, but is not limited to, blood, smears, sputum, urine, feces, body fluids, bile, gastrointestinal secretions, lymph, osteosarcoma bone marrow, organ extraction And or tissue sections. These samples taken from an individual or patient can be determined using techniques well known to those of ordinary skill in the art. Furthermore, it is well known in the art that DNA can be isolated from the sample using known methods and reagents, such as extraction of DNA using phenol/chloroform or in a commercial kit.

At least a portion of the present disclosure is based on the discovery of the degree of differential methylation (especially hypermethylation) of one or more target genes in an individual as a function of tumor progression and tumorigenesis. Thus, these target genes can be used alone or in combination as biomarkers for predicting the risk or susceptibility of an individual to have a tumor or tumor, determining the degree of malignancy of the tumor and/or assessing the prognosis of the tumor patient. Furthermore, individualized treatment guidelines can be tailored based on the degree of methylation of related genes in the patient. For example, for patients with one or more highly methylated target genes, a demethylating agent or other epigenetic drug can be administered to treat the tumor.

In view of this, the present disclosure provides various diagnostic and/or prognostic methods, which are listed below, respectively. For example, all methods herein encompass the determination of the methylation status or degree of methylation of at least one target gene. Therefore, the common steps in most (or all) of the requested methods are explained below.

In accordance with various aspects and/or embodiments of the present disclosure, the method involves a living body, and the steps common to the method comprise: sampling step (a), obtaining a biological sample from the individual; at least one methylation The measuring step (b) determines the methylation status of at least one target gene in the sample; and at least one determining step (c) determines whether at least one target gene is highly methylated. The method according to some embodiments of the present invention directly uses a biological sample, such as a tissue section sample, a cervical scraping cell, and a body fluid sample (e.g., blood or urine); at this time, the sampling step (a) may be omitted. Next, the resulting methylation profile is used to diagnose and/or assess prognosis, as described below with reference to various aspects of the disclosure and representative embodiments.

According to various embodiments of the present disclosure, the sample is a sample taken from a body (preferably a human body) or a sample originally present in an individual (preferably a human body); the sample includes tissue, tissue sample or Cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excision, open, incision, endoscopic, cervical scraping , uterus scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (including plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from an individual's ovarian tissue, a cell sample (eg, a cervical scraping cell), and a body fluid (eg, serum and plasma).

Regarding the step (b), in the experimental examples presented below, methylation is determined by qMSP or sulfite pyrophosphate sequencing, but it is conceivable that the method of the present invention is not limited thereto: The scope encompasses an equal method that quantitatively determines the methylation status or extent of a particular gene. Moreover, the above methods and their equalization techniques are also applicable to the embodiments described below; therefore, for the sake of brevity, the methods applicable to determining the methylation status or extent are not repeated in the aspects/embodiments described below.

In the present disclosure, the present disclosure proposes a method for assessing whether a body has a gynecological tumor, the method comprising the above-described common steps (a), (b) and (c), and an evaluation step (d); In this step, based on the result of step (c), it is determined whether the individual has a gynecological tumor. In particular, the hypermethylation of at least one of the above-described target genes represents that the individual has a gynecological tumor. According to some embodiments of the present disclosure, the absence of hypermethylation of the at least one target gene indicates that the individual is not benign with a gynecologic tumor or a gynecological tumor thereof.

According to various embodiments of the present disclosure, the at least one target gene is selected from the group consisting of ADAMTS16, APBB1IP, CBLN4, CCDC140, CELF4, CNTNAP5, EFS, EMILIN1, FERD3L, FEZF2, GALNTL6, GRIA4, NEFL , PARP15, PAX6, PRLHR, SSTR1, ST8SIA5, VWC2, ZNF300, ZNF334, ZNF662, CCDC105, CYP26C1, HORMAD2, IFFO1, LOC100130872, NKAPL, PCDHGA11, SLC25A2, TCTEX1D1, TMEM101, TRIM61, WDR69, AOX1, CACNA2D4, COL6A3, CPEB1 , FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2, GIGYF1, GSX1, KIAA1731NL, LBX2, LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, NRN1, PFN3, PHOX2A, PIP4K2A, PYGO1, SKOR1, SKOR2 TBX15, TBX5-AS1, UCKL1, WDR86, ZDHHC19, APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669.

In an equally optional embodiment, the at least one target gene is selected from the group consisting of ADAMTS16, APBB1IP, CBLN4, CCDC140, CELF4, CNTNAP5, EMILIN1, FERD3L, FEZF2, GALNTL6, GRIA4, NEFL, PAX6 , PRLHR, SSTR1, ST8SIA5, VWC2, ZNF300, ZNF334, ZNF662, CCDC105, CYP26C1, HORMAD2, IFFO1, LOC100130872, NKAPL, PCDHGA11, SLC25A2, TCTEX1D1, TMEM101, TRIM61 and WDR69.

Alternatively, the at least one target gene is selected from the group consisting of AOX1, CACNA2D4, CBLN4, CCDC140, CYP26C1, EMILIN1, FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2, GIGYF1, GSX1, KIAA1731NL, LBX2. LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, NRN1, PCDHGA11, PFN3, PHOX2A, PIP4K2A, PRLHR, PYGO1, SKOR1, SKOR2, TBX5-AS1, UCKL1, WDR86, ZDHHC19, APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669.

A second example of the present disclosure relates to a method for assessing whether an individual has malignant endometrial cancer. The method also comprises the above common steps (a), (b) and (c), and an evaluation step (d); in this step, based on the result of the step (c), determining whether the individual has a malignant endometrium cancer. In particular, hypermethylation of at least one of the above-described target genes indicates that the individual has malignant endometrial cancer. According to some embodiments of the present disclosure, the absence of hypermethylation of the at least one target gene indicates that the individual is not suffering from an endometrial tumor or an endometrial tumor thereof.

According to various embodiments of the present disclosure, the at least one target gene is selected from the group consisting of ADAMTS16, APBB1IP, CBLN4, CCDC140, CELF4, CNTNAP5, EFS, EMILIN1, FERD3L, FEZF2, GALNTL6, GRIA4, NEFL , PARP15, PAX6, PRLHR, SSTR1, ST8SIA5, VWC2, ZNF300, ZNF334, ZNF662, CCDC105, CYP26C1, HORMAD2, IFFO1, LOC100130872, NKAPL, PCDHGA11, SLC25A2, TCTEX1D1, TMEM101, TRIM61 and WDR69.

According to various embodiments, the at least one target gene is selected from the group consisting of APBB1IP, CELF4, EFS, FEZF2, GRIA4, NEFL, PAX6, FERD3L, SSTR1, ZNF300, ZNF334, and ZNF662.

According to various embodiments, the at least one target gene is selected from the group consisting of CELF4, FERD3L, FEZF2, EFS, PARP15, ZNF300, ZNF334, and ZNF662.

In an alternative embodiment, the at least one target gene is selected from the group consisting of ZNF300, ZNF334, and ZNF662.

Still alternatively, the at least one target gene is selected from the group consisting of EFS, FEZF2, and ZNF300.

According to some embodiments of the present disclosure, in step (b), the methylation status of two, three or all of the genes in EFS, FEZF2 and ZNF300 is determined.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of CELF4, EFS, ZNF334, and ZNF662.

According to certain embodiments of the present disclosure, in step (b), the methylation status of two, three or all of the genes in CELF4, EFS, ZNF334 and ZNF662 is determined.

A third aspect of the present disclosure relates to a method for assessing whether a subject has an ovarian tumor. According to various embodiments of the present disclosure, the presence or absence of an ovarian tumor is determined based on the result of step (c). More specifically, hypermethylation of at least one of the above-described target genes indicates that the individual has an ovarian tumor.

According to various embodiments, the at least one target gene is selected from the group consisting of AOX1, CACNA2D4, CBLN4, CCDC140, COL6A3, CPEB1, CYP26C1, EMILIN1, FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2, GIGYF1 GSX1, KIAA1731NL, LBX2, LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, NRN1, PCDHGA11, PFN3, PHOX2A, PIP4K2A, PRLHR, PYGO1, SKOR1, SKOR2, TBX15, TBX5-AS1, UCKL1, WDR86, ZDHHC19, APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669.

In certain embodiments, the at least one target gene is selected from the group consisting of AOX1, CACNA2D4, CBLN4, CCDC140, COL6A3, CPEB1, CYP26C1, EMILIN1, FAM101A, FAM115A, FBXL22, FIGLA, FLJ32255, FOXB2 GIGYF1, GSX1, KIAA1731NL, LBX2, LINC00925, LINC01210, LINC01475, LOC283692, LOC440982, MIR124-2HG, MKX, PCDHGA11, PFN3, PHOX2A, PIP4K2A, PRLHR, PYGO1, SKOR1, SKOR2, TBX5-AS1, UCKL1, WDR86, ZDHHC19, APBA1, CACNA1A, CBS, CIDEB, CKB, COLQ, FAM49B, NR5A2, OSBPL2, PCDH17, RYK, SDPR, SKIL, TEAD1 and ZNF669.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of AOX1, FAM115A, NRN1, PCDHGA11, PHOX2A, PYGO1, TBX15, UCKL1, and WDR86.

According to some embodiments of the present disclosure, the at least one target gene is NRN1, TBX15 or both.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of FEZF2, PAX6, and ZNF662.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of AOX1, CACNA2D4, COL6A3, CPEB1, FAM115A, NRN1, TBX15, PCDHGA11, PHOX2A, UCKL1, and WDR86.

According to some embodiments of the present disclosure, the at least one target gene is selected from the group consisting of NRN1, AOX1, TBX15, and COL6A3.

A fourth aspect of the present disclosure relates to a method for assessing whether a body has an ovarian tumor and whether the ovarian tumor is malignant; in the method, based on the height of at least one target gene determined in step (c) The result of the basicization is used to make the above judgment.

According to various embodiments, the at least one target gene is selected from the group consisting of NRN1, AOX1, TBX15, COL6A3, and WDR86.

According to embodiments of the present disclosure as desired, the method further comprises evaluating step (d); in this step, hypermethylation of at least one target gene indicates that the individual has an ovarian tumor, and AOX1, WDR86 or The high methylation of both indicates that the ovarian tumor is malignant.

A fifth aspect of the present disclosure relates to a method for assessing whether a body has a colon tumor.

According to some embodiments of the present disclosure, the method comprises the steps of:

(a) obtain the same copy from the individual;

(b) determining the methylation status of at least one target gene in the sample, wherein at least one target gene is selected from the group consisting of PAX6, TBX15 and ZNF334;

(c) determining whether the at least one target gene is highly methylated;

(d) Assessing whether the individual has a colon tumor based on the result of step (c), wherein hypermethylation of at least one target gene indicates that the individual has a colon tumor.

As can be appreciated, in step (c), the methylation profile of one or more target genes can be determined using the manner described above for other aspects/embodiments of the present disclosure.

According to various embodiments of the present disclosure, the sample is a sample taken from an individual; for example, from a colon tissue of an individual.

In the following, a plurality of experimental examples are set forth to illustrate certain aspects of the present invention, and the present invention is not limited by the scope of the present invention. It is believed that the skilled artisan, after reading the description set forth herein, may fully utilize and practice the invention without undue interpretation. All publications cited herein are hereby incorporated by reference in their entirety.

Materials and Methods

Tissue sample

All tissue samples were from the Taipei Medical University's Shuanghe Hospital (New Taipei City, Taiwan). A total of 233 adult tissue samples were collected; the samples were obtained with the written consent of the patient and approved by the Human Health Committee of the Shuanghe Hospital of Taipei Medical University.

Immediately after surgery, ovarian or tumor samples were taken and frozen in liquid nitrogen and stored at -80 °C for subsequent use. A tissue test was performed by a gynecologist and pathologist to perform a pathological diagnosis of each sample. The ovarian epithelial cells of the uterine fibroids were scraped to obtain normal epithelial ovarian tissue samples.

Sampling of endometrial tumor samples and normal endometrial tissue

In order to study the target genes of cervical tumors, cervical scraping cells were obtained from patients diagnosed with benign ovarian tumors or malignant tumors and female patients without ovarian and cervical diseases at the sampling site. For endometrial tumors, cervical scraping cells are obtained from a female patient diagnosed with uterine fibroids or malignant endometrial tumors and without ovarian and cervical disease at the sampling site. The procedure for collecting endocervical scraping cells is as follows. Extend the new internal cervical sampling brush into the inner cervical canal, then gently rotate the sampling brush three to five times to ensure that the sampling is true. Thereafter, the sampling brush was immersed in a centrifuge tube (15 ml) containing 2 ml of RNA later ® (Ambion; Life technologies; USA), and then the centrifuge tube was capped. The inner cervical scraping cell sample was stored at 4 °C. After mixing for 10 seconds with an oscillator, the samples containing the scraped cells were evenly distributed into three centrifuge tubes (1 ml per tube) and stored at -80 °C until use.

In the discovery cohort, there were 75 malignant ovarian tumor samples, 20 benign ovarian tumor samples, and 6 normal ovarian tissue samples, all of which were from different patients. These samples were used for wild-type whole-genome body armor. The study of the basic map. In addition, for endometrial tumors, published data from the Cancer Genome Atlas (TCGA) (including 371 malignant endometrial tumor tissues and 46 normal endometrial tissues) and from Em-MethylCap-seq (publicly available data on 80 malignant endometrial tumor tissues and 10 endometrial tissues).

The validation cohort used 20 malignant ovarian tumor samples, 5 normal ovarian tissue samples, 15 cervical scraping samples taken from individuals with malignant ovarian tumors, and 15 cervical scraping samples taken from 15 normal ovaries. These samples were taken from different patients and used here to validate differential methylation profiles of ovarian tumors. In addition, 24 malignant endometrial tumor samples, 20 normal endometrial tissue samples, and 31, 40, and 56 were taken from patients with malignant endometrial tumors and uterine fibroids, as well as normal endometrial individuals. Cervical scraping samples were taken from different patients and used here to validate differential methylation profiles of ovarian tumors.

To validate the methylation biomarkers of abnormal cervical scraping samples, 5 samples from each of the following groups were used: normal, cervical intraepithelial neoplasia 1 (CIN1), CIN2, CIN3/cervical Carcinoma in situ (CIS) or squamous cell carcinoma of the cervix (SCC).

To validate methylation biomarkers for benign tumors, including endometrial hyperplasia, benign ovarian tumors, and uterine fibroids, the following samples were used: 10 uterine fibroid tumor tissues, 10 benign ovarian tumors, and 6 uterine muscles. Cervical scraping samples of tumor patients, 11 cervical scraping samples taken from patients with benign ovarian tumors, and 5 cervical scraping samples taken from patients with endometrial hyperplasia.

2. Whole genome DNA methylation analysis

2.1. MethylCap sequencing

Two micrograms of genomic DNA was processed using the MethylMiner methylated DNA delta kit (Invitrogen, Carlsbad, CA) and according to the manufacturer's instruction manual to obtain methylated DNA. Briefly, genomic DNA was ultrasonicated to approximately 200-bp, captured as MBD protein, and precipitated using 1 M salt buffer. Sequence libraries are generated for sequencing using a methylated DNA-rich sequence according to the standard protocol provided by Illumina (San Diego, CA). The MethylCap-seq sequence library was sequenced using the Illumina Genome Analyzer IIx System. Image analysis and base determination using the standardized Illumina pipeline. The unique reading (up to 36-bp reading) and the human reference genome (hg18) were mapped using the ELAND algorithm and allowed pairing errors of up to two base pairs.

The unique paired readings were used for further normalization and differential methylation analysis. The degree of methylation is calculated by accumulating the number of readings according to the following formula 1 and formula 2. (Formula 1) N_(Read, i) is the number of normalized readings at the i-th basket (bin); U_(Read, i) is the number of readings that are uniquely paired at the i-th basket; and N_U Is the total number of unique pairs of readings. "INT" is the closest integer component to the negative infinite direction; and "^" is the power operator. The average degree of methylation is used to represent the extent of methylation. When comparing groups A and B (G = Aor B), calculate the average methylation degree of two groups in a specified region R (the frame size is m and the start frame is the sth) (AVG) _{R, G} ). The number of samples for group A is S_A, and the number of samples for group B is S_B. (Formula 2)

AVG _{R, G} represents the average degree of methylation of group G in the R region. M _R,G is the degree of methylation of each sample in group G in the R region. The two-tailed and Mann–Whitney U test was used to confirm the statistical significance of the different arbitrage in the R region (P ≤ 0.001). Analyze the differential methylation locus between the individual sample and the control sample.

2.2. 450K methylated bead array

The TCGA database uses a 450K methylated wafer array to analyze tissue samples, and the database includes data sets from 417 endometrial tissues. In these data sets, this study selected 371 cancer cases with neoplastic cellularity greater than 40%. Non-parametric experiments were used to investigate differential methylation of CpG sites between individual samples and control samples. A differentially methylated (top 5%) probe with P < 0.001 and a higher beta value was initially selected. Thereafter, a significant probe located within the range of -1000 to +1000 at the transcription initiation site of the coding gene was identified. The highly methylated selected for this study carries at least five probes identified using the methods described above.

2.3. Preparation of genomic DNA and sulfite conversion

Genomic DNA was extracted from the samples using the QIAmp DNA Mini Kit extraction kit (QIAGEN GmbH, Hilden, Germany). Genomic DNA (1 μg) was sulfite modified and dissolved in 70 μL of nuclease-free water using the EZ DNA Methylation Kit kit (ZYMO RESEARCH, CA, USA) and following the manufacturer's recommendations. DNA methylation analysis was carried out using the above sulfite DNA as a template.

3. Quantitative DNA methylation polymerase chain reaction

3.1. Quantification of methylation-specificity polymerase chain reaction (qMSP)

In quantitative methylation-specificity PCR (qMSP), this experiment used a specificity probe and primer (Table 2) to identify the DNA methylation of the 3-8CpG position relative to the unmethylated (COL2A1) total input DNA. Degree. If the Cp value of COL2A1 is greater than 36, it is determined that the sample DNA is an unqualified sample.

Quantitative methylation-specificity PCR (qMSP) was performed using specific probes and primers to confirm the relative degree of DNA methylation with reference to the total input DNA of unmethylated (COL2A1).

3.2. Sulfite Pyrophosphate Sequencing

The degree of DNA methylation is quantified by sulfite pyrophosphate sequencing, and the degree of methylation is expressed as a percentage of the degree of methylation at each CpG position in the pyrophosphate sequenced amplification (eg, 0% to 100%). ).

4. Statistical analysis

4.1. Differential methylation analysis

Non-parametric experiments between different groups and percentile ranking of the differentiated median. The Mann-Hui U test is used to analyze whether the average values of the two unpaired groups are equal or unequal. Paired samples between the two groups were compared using the Wilcoxon signed-rank test.

4.2. Area under the curve (AUC)

In the independent cohort, the true operating rate (ie, sensitivity) and the false positive rate (1 minus the difference in specificity) were plotted to obtain the receiver operating characteristic curve (ROC). ). To assess the best accuracy, the area under the curve (AUC) was used to confirm the optimization threshold to distinguish between the two samples from the different groups. Bootstrapping was performed 100 times and the cloes.left method using the pROC kit R (version 3.1.1) was used to find the best accuracy and threshold.

Experimental example 1

Identification of highly methylated genes associated with malignant endometrial cancer

In the discovery group, data sets from Em-Methy Cap-seq and TCGA methylated bead wafers were used to identify highly methylated genes in endometrial cancer. A differential methylation region (DMR) within ±1 kb of the transcription initiation site (TSS) of each gene was identified. In the first analysis phase, the degree of methylation of the gene between the tumor and the normal sample was compared in the Em-MethyCap-seq data set, thus identifying 400 genes. In addition, the degree of methylation of genes between tumors and normal samples was compared in the TCGA data set to identify candidate genes. From endometrial tumors (n = 372) to normal tissues (n = 46) and between the same individual (n = 33) tumors and normal samples, 466 genes with consistently high methylation levels were identified. From the data of these two sets of whole genomes, 176 genes showing consistent hypermethylation were identified. After screening in the selection categories proposed in this case, 56 genes were selected. In the second phase of analysis, between type I endometrial tumors (n = 271) and normal samples (n = 40) and type II endometrial tumors (n = 82) and normal samples (n = 18) In the meantime, 70 genes showing consistent high methylation were identified. After screening in the selection category proposed in this case, 59 genes were selected. A total of 109 candidate genes were selected from the first and second analysis stages; 35 of them (see Table 1), and there was no previous literature reporting the relationship between hypermethylation and malignant endometrial cancer. Specifically, the accuracy of these 35 genes in identifying malignant and non-malignant endometrial tissues is between about 75% and 99.04%.

Further validation revealed that 35 candidate genes were selected from the group, and the mixed DNA from normal endometrial tissue (N, n = 20) and malignant endometrial cancer tissues (T, n = 24) was subjected to sulfite pyrophosphate. sequence. The results of the analysis (Figure 1) show that 12 of the candidate genes are highly methylated in malignant endometrial cancer tissues. The 12 genes are: APBB1IP, CELF4, EFS, FEZF2, GRIA4, NEFL, PAX6, FERD3L, SSTR1, ZNF300, ZNF334 and ZNF662. Table 1 *The best accuracy is calculated using the Em-MethyCap-seq data. The threshold is the optimal threshold value calculated using the close.left method of the pROC set. Using data from the TCGA 450K methylation array, those with a methylation level above the threshold were positive and below the threshold were negative to calculate sensitivity, specificity, and accuracy.

In addition, a cervical scraping sample from a patient diagnosed with a malignant endometrial tumor (Tswab, n = 15) and a normal endometrial tissue (Nswab, n = 10) was used to mix the DNA for sulfurous acid. Salt pyrophosphate is sequenced for further use to validate candidate genes. The results of the analysis (Fig. 2) show that the above 12 genes can also be used to identify individuals with malignant tumors and normal endometrial tissue by cervical scraping.

The methylation profiles of the above 12 candidate genes were further analyzed. The analysis in Figure 3 shows that for CELF4, EFS, ZNF334, and ZNF662, the methylation profile is in normal individuals (N, n = 56), uterine fibroids (M, n = 40), and malignant endometrial cancer tissues. There was a difference between patients (T, n = 31).

These four genes (ie, CELF4, EFS, ZNF334, and ZNF662) were used in subsequent independent groups to determine the best accuracy of their diagnostic and/or prognostic clustering abilities.

Experimental example 2

Identifying the best accuracy of patients with benign endometrial tumors and patients with malignant endometrial tumors

In the independent group, the ROC map was drawn; in addition, the thresholds, AUC, and 95% confidence intervals of the four genes identified in Example 1 and ZNF200 were measured, and the results are shown in Table 2. Table 2

The data in Table 2 show that these five genes (CELF4, EFS, ZNF330, ZNF334, and ZNF662) show considerable accuracy when identifying normal individuals with endometrial tissue (N) and patients with malignant endometrial tumors (T). Degree (71% to 80.2%). In addition, the AUC of these five genes is quite close to 1, indicating that this is the preferred collection. Four of the more accurate genes (ie, CELF4, EFS, ZNF334, and ZNF662) were selected for subsequent analysis to confirm the performance of each gene combination.

Experimental example 3

Identify the best combination of genes in patients with benign endometrial tumors and patients with malignant endometrial tumors

The pROC kit was used to confirm the optimal threshold for each gene. Those with a degree of methylation above the threshold are positive, while those with a degree of methylation below the threshold are negative. The results of the analysis of Figure 4 show that some combinations of 3-genes yield at least 90% of the area under the curve (AUC). Specifically, a 3-gene combination (ie, CELF4/ZNF662/EFS combination or CELF4/ZNF662/ZNF334 combination) can also be used to identify patients with malignant endometrial tumors (EC, n = 31) and patients with non-malignant endometrial tumors. (Includes normal patients (N, n = 56) and uterine fibroids (Myo, n = 40)) with an AUC of 0.95. The ability to discriminate between the above 3-gene combinations is superior to any single gene.

Experimental example 4

Identification of highly methylated genes associated with ovarian cancer

In the discovery group, data sets from Ov-Methy Cap-seq were used to identify highly methylated genes in ovarian cancer. Identify DMRs within ±1 kb of each gene TSS. In the first analysis phase, the degree of methylation of genes between tumor (n = 75) and normal (n = 10) samples was compared in the Ov-MethyCap-seq data set, thus identifying 964 genes. After screening in the selection categories proposed in this case, 66 genes were selected. There are four major subtypes of ovarian tumors, namely, serous, endometrioid, mucinous, and clear cell types. Thus, in the second analysis phase, 124 genes that exhibit consistent hypermethylation in either of the two subtypes are identified. After screening in the selection categories proposed in this case, 52 genes were selected. A total of 130 candidate genes were selected; 51 of them (see Table 3). There was no previous literature reporting the relationship between hypermethylation and malignant ovarian cancer. Specifically, the accuracy of these 51 genes in identifying malignant and non-malignant ovarian tissue is between about 71% and 95.12%.

Further, 51 candidate genes selected in the group were found to be subjected to sulfite pyrophosphate sequencing from a mixed DNA of normal ovarian tissue (N, n = 5) and malignant ovarian cancer tissue (T, n = 20). The results of the analysis (Figure 5) show that 9 candidate genes can be used to identify malignant ovarian tumors and normal ovarian tissue. The nine genes are: AXO1, FAM115A, NRN1, PCDHGA11, PHOX2A, PYGO1, TBX15, UCKL1 and WDR86.

In addition, cervical scraping samples from patients diagnosed with malignant ovarian tumors (Tswab, n = 15) and normal ovarian tissue (Nswab, n = 15) were used to mix the DNA for sulfite pyrophosphate sequencing. To further validate candidate genes. The results of the analysis (Fig. 6) show that the above 9 genes can also be used to identify individuals with malignant ovarian tumors and normal ovarian tissue by cervical scraping. table 3 *The threshold is the optimal threshold calculated using the close.left method of the pROC set. Using data from Ov-MethyCap-seq, those with a methylation level above the threshold were positive and below the threshold were negative to calculate sensitivity, specificity, and accuracy.

The methylation profiles of the above 9 genes were further analyzed. The analysis of Figure 7 shows that the methylation profiles of NRN1 and TBX15 in tissue samples were between normal individuals (n = 56), uterine fibroids (n = 10), and malignant ovarian cancer patients (n = 20). There are differences. What's more, in the cervical scraping sample, the methylation profiles of NRN1 and TBX15 were in normal individuals (n = 15), patients with uterine fibroids (n = 10), and patients with benign ovarian tumors (n = 10). There were also differences between patients with malignant ovarian cancer (n = 15).

Experimental example 5

Interactive test of candidate genes with other gynecological cancers

Further investigation of the ability of FEZF2, PAX6 and ZNF662 in the identification of abnormal gynecological diseases, the results are summarized in Figure 8 (each symbol represents mixed DNA from 5 people). In ovarian tissue samples, FEZF2 and PAX6 have higher degrees of methylation in malignant ovarian tumors, respectively (compared to their degree of methylation in normal ovarian tissue). In cervical scraping samples, FEZF2 and PAX6 also have higher methylation levels in malignant ovarian tumors, cervical intraepithelial neoplasia (CIN3) or cervical squamous cell carcinoma (SCC). Its degree of methylation in normal ovarian tissue or cervical intraepithelial neoplasia (CIN1)).

Experimental example 6

Decision threshold

The optimal threshold is calculated using the close.left method of the pROC set to determine if the target base is over-methylated. When the methylation degree of the target gene is higher than the threshold, the target gene is considered to be highly methylated; and when the methylation degree of a gene is lower than the threshold, the gene is not highly methylated. The sensitivity, specificity and accuracy of certain target genes were calculated using data from Ov Methy Cap-seq. The results are summarized in Table 4 below. Table 4

Using the M-index data from aMSP, the ROC method is used to calculate the threshold (ie, the optimal threshold) for identifying the target gene or target gene combination of the cancerous sample (n = 21) and the normal sample (n = 23), and The sensitivity and specificity were calculated; the results are summarized in Table 5 and Figures 9A to 9D. table 5

Using the M-index data from qMSP to calculate the threshold (ie, the optimal threshold) that can identify the target gene or target gene combination of the tumor sample (n = 29) and the normal sample (n = 23), and calculate the sensitivity Degrees and specificity; summary of results are summarized in Table 6 and Figures 10A through 10D. Table 6

Using the M-index data from qMSP to calculate the threshold (ie, the optimal threshold) that can be used to identify the target gene or target gene combination of a benign tumor sample (n = 10) and a malignant tumor sample (n = 19), and calculate Its sensitivity and specificity; the results are summarized in Table 7 and Figures 11A to 11D. Table 7

Experimental example 7

Diagnosis of ovarian tumors

In this experimental example, a sample from the cervical examination was used and diagnosed. First, when at least one of NRN1, AOX, TBX15 and COL6A3 is highly methylated, the sample is classified as a positive sample (ie, with ovarian tumors); and when NRN1, AOX, TBX15, and COL6A3 are not highly methylated When the sample was classified as a negative sample (sensitivity 88.5%; specificity 95%). Thereafter, when one or both of WDR86 or AOX1 are highly methylated, the positive sample is further classified as a malignant ovarian tumor sample; and when the positive sample of WDR86 and/or AOX1 is not hypermethylated, Classified as a benign ovarian tumor sample (sensitivity 90%; specificity 81.8%).

Experimental Example 8

Diagnosis of colon tumor

Paired samples were obtained from colon tumors (colon T) from 18 patients and normal colon tissue tumors (colon N) at adjacent tumors. The methylation profiles of PAX6, ZNF334 and TBX15 in normal and tumor samples were established using the methods and data described in the experimental examples above, as shown in FIG. The results of the analysis indicate that the above genes can be used to identify normal colon tissue and colon tumors (whether benign or malignant). All P values < 0.001; two-tailed Man-Hui U test.

Although the embodiments of the present invention are disclosed in the above embodiments, the present invention is not intended to limit the invention, and the present invention may be practiced without departing from the spirit and scope of the invention. Various changes and modifications may be made thereto, and the scope of the invention is defined by the scope of the appended claims.

no

The above and other objects, features, advantages and embodiments of the present invention will become more <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; Degree of methylation of candidate genes; Figure 2 summarizes the degree of methylation of 12 candidate genes in a cervical scraping sample according to an embodiment of the present disclosure; Figure 3 summarizes an embodiment in accordance with the present disclosure Using DNA methylation of individual cervical smears to detect endometrial cancer; Figure 4 is a graph showing the combination of three genes when using a cervical smear to detect endometrial cancer according to an embodiment of the present disclosure. Area under curve (AUC); FIG. 5 summarizes the degree of methylation of nine candidate genes in an ovarian tissue sample according to an embodiment of the present disclosure; FIG. 6 summarizes an embodiment according to the present disclosure, Degree of DNA methylation from cervical smears diagnosed with malignant ovarian tumors and normal ovarian patients; Figure 7 summarizes an embodiment of the present disclosure in the uterus In samples of fibroids, benign and malignant ovarian tumors, NRN1 and TBX15 are highly methylated; Figure 8 summarizes the interactive testing of candidate genes in other gynecological cancers according to an embodiment of the present disclosure; Figure 9A through Figure 11D Specificity and rush of certain target genes in diagnosing ovarian tumors; and Figure 12 summarizes DNA methylation from colon samples from patients diagnosed with colon tumors and normal colons in accordance with an embodiment of the present disclosure degree.

<110> Lai Hongzhen <120> Method for diagnosing and predicting tumors <130> P2971-TW <150> US62244116 <151> 2015-10-20 <160> 82 <170> BiSSAP 1. 3     <210>   1   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ADAMTS16     <400>   1   Cgtgtactcg   Cgcacacgca   Gtcaggtgtg   Gatgtacacc   Cgcgcacacc   Caggcacatg   60     Tacacccgcg   Cgctcacaca   Ccccatccag   Ctacagcaga   Attctggcca   Ggctgttgac   120     Cgcacacctg   Ctgcctcctt   Ggccaccctg   Tccacacagt   Agcccgatcg   Acccccgtgg   180     Cggccgagac   Ccaggcccat   Ccgcagccct   Gagacctccc   Tagggattgc   Acccagcagc   240     Cagtcaccgg   Cctccgcggc   Ctggccagtt   Gagggtggcc   Gtgaccgcgg   Ggccaggagc   300     Gccgccacat   Ctcggggcaa   Atggcgcggg   Ggaagagttt   Cctcctcagc   Ctccccgtct   360     Ccgatcgctc   Cgcaaactcc   Agagcgaggc   Acgcgccttt   Aaaggcaggt   Ccgcggctct   420     Cccacgtcct   Ggcgcccggt   Tttccgcacc   Cagtgtcccc   Acagctgtgc   Ccgggcacag   480     Aggcgcggcc   Agacgcact   Ccgcgggctg   Caggtgtccc   Ggcctctggc   Ggcgccggtg   540     Cggcccggag   Gtgggagccc   Gcggagccac   Tgcagtagct   Ggagtcccgc   Cgagtcccca   600     Gccccaaggc   Agggcaggag   Cgcgcaccgg   Ccggaggtcc   Atgctgagca   Tcgcccgcgc   660     Cggtgcccgg   Cagcctctcc   Aactgtgtgg   Tccccgcgcg   Ggcagagagg   Cacggactgc   720     Aggccgtggg   Cagctccatc   Ttcccgcgtc   Ctcctcctct   Ggcgctgccc   Gctgtctccc   780     Gccttccctc   Tgctccccgc   Tcgcctccgc   Ctcagcgccc   Cgctgacctc   Gcctcctccc   840     Ctctgctctt   Tgtccctgca   Ctctcccctc   Ctcggtcctc   Tgaccccccc   Gccctcacct   900     Cctcccctcc   Tctctcccct   Gcccgccccg   Cgctctccca   Ccgctcccgc   Cgcccccgcc   960     Gccgcggctg   Ccactccgcc   Ccccgcgccg   Cacggagctt   Cagtaataac   Cccggcgcgg   1020     Cggcggagtc   Gctgtgggga   Atcctcccgc   Gctctgcctg   Ggtcgggtcc   Tccctgcccg   1080     Ctcgcacgct   Gccggccggg   Gaccctccgg   Tggcccctag   Cccctcggag   Cgctcctgga   1140     Tgaagccccg   Cgcgcgcgga   Tggcggggct   Tggcggcgct   Gtggatgctg   Ttggcgcagg   1200     Tggccgagca   Ggtgagtccc   Gggcgctccc   Accagcgcgg   Aaaccgcggg   Tccggacagc   1260     Tggaggcgag   Tcccccgcgg   Ctcctctccc   Gcggaccccg   Ccgtctcacc   Gcgatgtcgc   1320     Cgctgttttc   Cgcaggcacc   Tgcgtgcgcc   Atgggacccg   Cagcggcagc   Gcctgggagc   1380     Ccgagcgtcc   Cgcgtcctcc   Tccacccgcg   Gagggggggg   Gctggatgga   Aaagggcggt   1440     Aagtccgtga   Ggtgggggct   Tctaatcctt   Gccatttagc   Agctcgtaat   Ctccgtgccg   1500     Ctggtttatt   Aggtgctgtg   Aatgttcacg   Actctgtgga   Accctacttt   Taagatgctg   1560     Ttgtgaactt   Tttttttttt   Taactgtatg   Agcgagcccc   Gatgagtgga   Tttccaccaa   1620     Tatttacatt   Tttatccctg   Gcaaaacggt   Ttgccagagt   Tattgatata   Acattaggaa   1680     Aaaggtgagg   Aagttcattt   Tattttattc   Taaagagctt   Aggaagaatc   Taaagctatt   1740     Aatgtatgca   Tcaaagccgt   Cataagagc   Aaattacttt   Cttttccgtc   Cccttctaca   1800     Tcctcggatc   Ctccttcccg   Tccccaacct   Ttcctccttc   Tcctccttta   Tagattaaaa   1860     Tattcctcta   Tcgttgctta   Ttctcagtga   Aggagataaa   Agaagcgctt   Agcatctcaa   1920     Taccaaagtt   Aatgctccaa   Caatcagggc   Gtacttcaaa   Catatatagg   Cctgaaatgg   1980     Ctaatcagct   Gattgtgaca   2000       <210>   2   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   AOX1     <400>   2   Aaaacgttga   Ccattgttaa   Agctcagtga   Agggcaggta   Gatgccaatt   Gcactcttca   60     Cttttatgtg   Caaagtttgg   Aaaatttcac   Aataaaattt   Ttgtgtttac   Ataaatgaaa   120     Taacatggga   Aaatgttcta   Aggtatggca   Agtgaaaaaa   Gcctggaaaa   Taactagttt   180     Gtcccactta   Agtttttaaa   Ggtgttaaaa   Gtacatgttt   Caaaaagtaa   Ggatagacta   240     Aaaaagtgaa   Cggtggtaag   Ttctaagttg   Tgggcttaca   Ggtgttcttt   Atttttatgc   300     Tttgctgtat   Tttccaagtt   Ttttttttta   Agttttccaa   Gatgttttac   Atctctgttc   360     Tttattacca   Gataaacttt   Gtggttagtt   Actggataaa   Ctgtaaatag   Tgataaaatt   420     Tttaagttta   Tatcaagata   Gcacttcatt   Ttaaaaccag   Taattattag   Gttggtgcaa   480     Aattaattgc   Agttgttgcc   Attggaagtg   Atggtaaaaa   Ccgcaattac   Ttttgcacca   540     Accttatatt   Tctaaaagat   Caagttgtaa   Acctatttgt   Tttccctaag   Atccgctctt   600     Gcagagttgg   Aataaatatg   Attgtttaca   Cttaagagtc   Caggactaca   Gcaggcctgg   660     Ttggagggga   Gttactaatg   Ttcccagact   Taaatccagc   Tggaacacca   Ctataaaatat   720     Gcagtaacat   Aagaccatca   Aaagcaatgt   Cccaggactt   Acaatgtttg   Ctaagacgca   780     Agagggtgtg   Acacagacgc   Taagcgccac   Tggcgaggag   Atgaaggggt   Cgtcttcatc   840     Ttcgccggat   Gatttccgcc   Cacatagagg   Gcgccagtga   Cgcccacaca   Cgtgctggtg   900     Tcccgggaag   Agttcctggc   Aaagagctca   Ggaacgttgg   Atcttaatca   Aggctttctc   960     Cgtcggggtg   Gatgggttgg   Actttaggct   Ccagcaagcc   Ccgccccact   Cggcgggtcg   1020     Gtgccgccgg   Gtcccaggtg   Cccgctactt   Cccagaacct   Ccgcctcccg   Ctccgggccc   1080     Tcgaaccagc   Gcggacacca   Caatggaccg   Ggcgtccgag   Ctgctcttct   Acgtgaacgg   1140     Ccgcaaggtg   Agcgcccgcg   Ggcttcctct   Gcccccagac   Ctgcggccag   Ggccggggca   1200     Gagaggagcc   Cctgccgttc   Gtcccatcct   Ttcgtgcccg   Ccgtttaagg   Cactcaggca   1260     Cggactggct   Ttctcccgta   Acagcggctt   Tgccttcgca   Ttcccacccc   Tgcctccggg   1320     Gcagctaaag   Gctgcgtttt   Cagggactgt   Cctggatctt   Tgggccccca   Ccttccttat   1380     Gttccccttt   Cctctccttc   Caaggctcac   Aagctgattt   Ccaaccacac   Gccctcccta   1440     Aacagtaaga   Taaaaagtat   Tcttgcccat   Caggggtcag   Cactcccaga   Tcttcgttcc   1500     Ctcaatccca   Gccgataacg   Ggaacgtccc   Cagtacactg   Agagcagcct   Acagaaatgg   1560     Ctgagcctca   Gctcgcgggg   Tgcgtttgga   Agcgcagaga   Gcaacttaga   Ttcgggacaa   1620     Gaccgtagag   Acgaacacat   Tcaaaccacc   Cccatcgttt   Ctcagatgaa   Gaaatcgtta   1680     Ctttccaaag   Tcacagctag   Ttcctggcag   Agctgaaccc   Aagtcaggct   Ctgggggctc   1740     Caaggtcctc   Acgggttcca   Ctgctgggtg   Cgggctctgt   Cgcctcagaa   Gctgggctcg   1800     Ctctgcgcaa   Cccgagggac   Agttccaggc   Agtgtccgat   Gtttgggaga   Agcaaagccc   1860     Cctgggcatc   Ctttaaaaca   Cccccttatta   Tgtgagcatc   Aactctgctc   Actcttaatg   1920     Ttccagtttc   Attgacatta   Ctctgaagga   Ggaaactgag   Gcaggaaggt   Taaggagctc   1980     Ccttgagagc   Tgtggctcac   2000       <210>   3   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   APBA1     <400>   3   Cggttatcct   Atttccctgc   Catgtgcctc   Aaagcaacat   Gctcacttcc   Acatccccat   60     Gtcatgaggc   Cagaggaagg   Ggaagcgaga   Atccctacac   Tgggccatcc   Acacgcagga   120     Gcagaacaga   Cactgtgctc   Agaggtgcag   Ggtcaaaata   Acaaacactg   Tcccacagtc   180     Ttagccggtg   Acatcaagta   Agggcagcgg   Cagatctctg   Gatttggggc   Gcagtttggg   240     Gaacgtggat   Gcaaccacac   Gcgtacacac   Acatatacag   Gattttacaa   Accggcccct   300     Atcccactgc   Ctccctccac   Acttcacaca   Ccaagtgcat   Cctgcccacc   Tcaccgtttc   360     Catcatcaca   Ttctttctcc   Aggagagtca   Gccgagagat   Gagggggtcc   Tagcggggat   420     Tcctggaaat   Gtcacccccc   Aacacctccg   Tccgccaccc   Catcccctct   Gctgtacctt   480     Ttacacacac   Actctcacac   Actcactcct   Gccatgactg   Tcatcaggcc   Cgcctgctgc   540     Gcccgaagcc   Cggcatctca   Gcgggcaccg   Gaccccaggc   Gtctcgctcg   Caacgccgcc   600     Ttcccccgcc   Tcgctagctg   Atggttccag   Gcactgcctc   Ctggatgtcg   Cctgctgcct   660     Ccgctcctcc   Gcactattgt   Tccaggcagc   Ccctctcgcg   Tccgggggcg   Ccctttggcg   720     Aggaccccgg   Ctccgtcggg   Ggccgcatca   Gcgccgggca   Ccccttctca   Cccacccctc   780     Cctggctgtg   Gtaccttgcc   Tgacagctgg   Gtccgcgggc   Ccgcgggagc   Aggcggcgct   840     Agtgacagcg   Ctggtgccaa   Gcctgggaat   Aaagctccgc   Tccagccgct   Gctgcctcca   900     Gcgccaccat   Cttctcccgc   Cgcagctgcc   Gccgccgccg   Ccgccgccgg   Gaccgcagcc   960     Gccctcgccc   Agctccggct   Ccgcagccgc   Tgctcggacc   Cctccggtct   Cgcggcccca   1020     Ccccctttcc   Ccaccctccc   Tcccgccctc   Cagctagctc   Gctggcccct   Cgtgacgcgc   1080     Gctggggccg   Ggcgggcctg   Cgagggaggg   Cgcgggggag   Cgcgcgcgcg   Cacgccgcct   1140     Gctagtagcg   Cccctgcctc   Cctcgcccac   Tcgcgtgcgc   Gcgcggcccg   Cgagcccgcg   1200     Gcggcggcgg   Cggcaccgct   Gatgtcctcc   Gtgggccgcc   Ggctgcagcg   Cccctgcccc   1260     Ggcgccggtg   Ggcgtgcggc   Acacccgcgc   Ctctcgcctt   Ccctcgcgtc   Cgggttccga   1320     Agggcccgcc   Ctgcctttcg   Gaatgggttc   Cacagcccca   Tcctctggct   Cccggccgga   1380     Cgcaaggagg   Ggaaaatgca   Gctgcatccc   Cgaggggact   Gacgggggcc   Tccaccctcc   1440     Tcggtggcaa   Cccaggtggt   Ccccagtttc   Ctagccagca   Gctgtggcca   Acctctgcgc   1500     Gaagcaacgg   Gccacgctgc   Aggaccacga   Agccaggcag   Ccgcgtcgac   Tcctgcaggg   1560     Tgttctctcc   Ggagtgactc   Ccgagctttc   Ccgcttccca   Ggccccttag   Atatcgcctg   1620     Cgcttcaaat   Tcggagattg   Acggcgtctc   Cggaatgcgt   Cgcagtcctg   Cgagttctcc   1680     Gccaggggga   Gagccgcgcg   Ggcttgggcc   Tgagcgaaga   Cagccgggct   Gcagccctcc   1740     Aggggaactg   Ccgagtcccg   Ccggggacag   Cggagagcct   Gcggattgtg   Aagccgagga   1800     Aggctcggct   Tggttttcct   Acccgctcct   Cagttctggt   Tgatcggaac   Ttaagtgtct   1860     Ttgagcctag   Cacaggccat   Ccgccctaga   Tatggctcct   Aactcgagag   Gccaccctttt   1920     Gcggcaggga   Ccaggtggca   Agtgctgtgc   Atatatgaaa   Agctgtgggc   Tagacaggcc   1980     Ccgggaggcc   Tgggctctgg   2000       <210>   4   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   APBB1IP     <400>   4   Aatatatttt   Ctatttattt   Atcgtttatt   Taccctaatt   Aatacagcaa   Ccccatcccc   60     Atgcccatca   Ctctctatcc   Ctcacctttt   Aacttccttc   Aaaactagtt   Acattccttg   120     Acatgttaaa   Tattaatttg   Tttattgtct   Gctttctacc   Aactagaatg   Caccatgcat   180     Gagagcagaa   Attgtttcct   Ctaactattt   Tcattgttct   Tagaagtgtt   Ggtgcttacg   240     Aatagtttct   Cattaaataa   Atgacagaac   Tatttgaaat   Tgcctaatta   Acacatgcac   300     Ctaatttctg   Tctttatgtc   Ttcaccacct   Tccctgacat   Ataagccttt   Gaagacacag   360     Ctgtagagga   Gaaggggagg   Gttattcaac   Cgcatttaca   Aatcataact   Gattttaact   420     Tctgtatttt   Cagacctccc   Cagcgacttt   Ctctcaggaa   Actccactcc   Caactgacag   480     Gtgctatttc   Cagccagtcc   Tatgctgttg   Caaatagtga   Gtccatgaat   Gccctctgcc   540     Gtgtgcatta   Cttattttca   Tcagcagatc   Ttcgtaacac   Actcctggaa   Gtgggatgac   600     Ggggtcaaaa   Ggcgaatcca   Tacataagtt   Aaatagatat   Tgctcaattc   Tcttccacgg   660     Ggttcagacc   Attttggatt   Tctacgagca   Atgaagacag   Tgctattcct   Ctacaccctg   720     Gccggccaac   Tgagcgtggt   Taaacgtggg   Gagggaggag   Ggtgaggtta   Ccaacctgat   780     Ggttgagaaa   Gggcctccgc   Ccaggccgcc   Cttcctccac   Ccccaccccga   Gagacagctg   840     Aactccggcc   Gggacgcgcg   Tgttgccagt   Ccagccctgc   Accgcgtccc   Ctgagggcgg   900     Gctgcaggcg   Gccgggaagc   Cttgcacaac   Cggcccaaaa   Gaggaagccc   Agaaagtgct   960     Gaagtaaaca   Ctttgggaga   Ccgttgcaac   Ataaagcggc   Ctctcagtct   Ttggtggaac   1020     Catcactagg   Ccccaatccc   Ttagtccctc   Ttgcgtcgag   Gctgcaaaat   Ggttccattc   1080     Gccaggagac   Gctcctgaga   Gaagggcgcg   Cgcggcacag   Gtagggggag   Gcgcaacgtt   1140     Tcccagaatt   Aaaataaaat   Aaaataaaat   Aaaataaaaa   Tcccttcaag   Gtggttgtgt   1200     Agtaggggtg   Ggatggggga   Gagaaaatca   Ggcgcagact   Cgatgagttg   Gagaaagcag   1260     Cccctacact   Ggagtccttt   Acgcatatgt   Ttgtctgtcc   Cactgtctct   Aaccaggggc   1320     Cttccttgca   Cctcggagca   Aagcagctcg   Gatagcgcca   Cacgtctgcg   Cgctgcgtgg   1380     Gaagggcagg   Gctgacagca   Cttcctcccc   Ggggcagcga   Cctggagccc   Gggtgcggca   1440     Gtctgcaccg   Cgcgtcgctt   Tcccggccgg   Agtctcgccg   Ccttcccgcg   Ccccgcagcg   1500     Ccccgcagag   Cagtcgaggt   Aagtggcgct   Cccagtcccg   Ggagccctgg   Gagcgccagc   1560     Acgggcccct   Cggggctgtc   Aggaacccgt   Ttgtcaagcc   Cgtcgggtcc   Gacgccgggg   1620     Gcagctccag   Gatctggcct   Cgtgaacgcg   Tgcccccagg   Cgtggccctc   Gagcgcagcg   1680     Ggtccccagg   Gtcccctccg   Ctgatctcca   Ctctggaccc   Ggctcgcgag   Ggtgggggtg   1740     Tgagggtttg   Gggttcgggt   Ttgctttttc   Ccgagctatt   Gcaacagatt   Tgacagattt   1800     Cctgcccagg   Aaattgctgc   Aaggtcaaac   Ggggaactgc   Tatgaaccct   Tgcacgtcca   1860     Gcaggtcagc   Aggtcagcag   Gtcagcaggt   Ccgggagccc   Cagtctcccg   Gaacctggag   1920     Ggattcttga   Ggggccaaga   Ttagatgtgg   Attaatgcc   Agccgtgtga   Gaatttgagt   1980     Gtggctcgca   Gtctgatgca   2000       <210>   5   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CACNA1A     <400>   5   Gctgtccagc   Ttccccggg   Tggactccag   Tgagcgacgg   Ccaagaaaac   Ccaaccaagg   60     Cccccatagt   Tcccctgccc   Tggccagaag   Cgcccaggcc   Cgagcccgct   Ccaagctcac   120     Tccgtagaac   Tccaaaccct   Ccggacttgg   Ctcgaaagcc   Cccaccaagg   Ctcctgcacg   180     Accccaggcc   Ccagatctca   Ttctagagtc   Ggtccttggg   Aaggatccac   Tctccgctgc   240     Cccacccccca   Gccccccaca   Aacccattcc   Caagcctcca   Gggtagctca   Acccagctcg   300     Gggtggagag   Attctttcac   Actcctcccg   Gtgccccctc   Tcccagcccc   Tggaagaccc   360     Ccctcctccc   Cacctcccat   Caacccccgg   Gtctctctcc   Cagcctggaa   Gaggggaggc   420     Ggagggagga   Gggggaggcg   Cagctgctgc   Tggggttcgg   Gcaaaaggat   Atggccattc   480     Ggtgatcttt   Ttggcgtatt   Ttctcaccac   Gttgtcttcg   Ctgaagagga   Agagagacg   540     Gttaaccgtg   Aggcagttct   Gtcggacggg   Gatggggttg   Tagagtgcca   Tggtccgcgc   600     Tctctgcgcc   Attgactgct   Tgtacatcct   Ttgcgccccg   Ggctgcccgc   Cctgccggct   660     Gcccccggct   Cctcgcccgc   Ctccgctgcc   Cacgaccacc   Ccggcggctg   Cccgggagcc   720     Tcctcccccg   Tagcgggccg   Gcatctcgtc   Tccgaagcgg   Gccattctgc   Aaagagcaaa   780     Gggctccggg   Ttacgctgcg   Gcgaacgatg   Cggaagacgc   Cgccgccgcc   Gccgccgccg   840     Ctgatgctga   Ggctgccggg   Gctgggagcg   Cggcggctgg   Agctacgact   Gcggagacgc   900     Tccacggccc   Agcccatcgg   Gcggcggcgg   Ctcggcgcct   Cgggtcgggg   Gctcagaagg   960     Cggctgcccg   Ggccgagccg   Gggatagcag   Ctcgggacat   Cttcctggct   Gaccccggag   1020     Aaggaggggc   Gggaggaggg   Tgcgggggcg   Gggcgcgggg   Gcccggggag   Gaggggggag   1080     Gggagagaga   Agcgaggcaa   Aaaataaccg   Aggaaggaat   Ccaggcaatc   Cccagtccac   1140     Ccactccgga   Aaaaaaaaaa   Aagagacagt   Taaaaaaaaa   Aaatccaccc   Aacgcacacc   1200     Ccctttaaga   Cgcgaacggt   Ttgcaaagga   Cgcccccccc   Gggacgcagt   Ggaagcttca   1260     Aattcctccg   Aggtccgggt   Caggctggca   Tcttgcaaaa   Ggagtgcgct   Cggcccatta   1320     Aaaaaaaata   Aaaaataaaa   Aataaaaaaa   Tatatatata   Tttaaaaata   Aagaaagacg   1380     Aaacccaggt   Ctgggtgggg   Agggcaaaaa   Aaaaaaaaaa   Aaaaattaag   Tgcccttctg   1440     Ttttgctgga   Gttcctagac   Cttaaaaatg   Ctgaaagatc   Tgtagctcca   Aaaataaaat   1500     Aaaataaaaa   Caaagaagat   Gaaagggaag   Ggaaagagga   Gggaagggga   Gtaagacgct   1560     Ccagagggt   Cctaaggagt   Cttcacaccg   Cagggtccag   Gtttaaaaaa   Aaaaaaaaaa   1620     Attttttttc   Ttcctgaatc   Accaacggct   Gcctcttctg   Ctcccggagg   Aagtgtgagt   1680     Gtgtatgtgc   Gcacagcgtt   Tcgctcaatg   Gtgcctcatc   Ttggggttaa   Attgcagcag   1740     Tgaaatcctg   Aaaattccca   Acagggggaa   Aagagagaga   Gagagaggta   Tgcgccctcc   1800     Gcttagccac   Tcaatagctg   Cccctggatg   Cggcaatgcc   Tctccaccct   Ccaaatccct   1860     Ccaccctcctc   Cttctctagg   Ttttgctaaa   Ataagactgg   Tgtggagggt   Tgcgggtaga   1920     Gaagaggtaaa   Gaggaaaaaa   Aaatgggcgc   Aaaggtctga   Accactggcc   Agcaaacgga   1980     Aaaggggagc   Aattgatgag   2000       <210>   6   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CACNA2D4     <400>   6   Aaaggtgtag   Aaagggaaga   Ctgcggccac   Caaaatccat   Ttttttcccc   Agttcctgga   60     Caagccacct   Cctgtgcgca   Tgagacgttc   Tgtgggttca   Gaactgcttc   Ccctttttgg   120     Aatgtcaaaa   Tacgcatttc   Ctgccaaatg   Cttcggggag   Ctgcgatgct   Gagataaccc   180     Ggctcctcca   Ggctgcctca   Tctcagcgat   Tatcctgaag   Gagcacccgc   Ccttcaggtg   240     Tcccagaagc   Tgcttgtcag   Gccaggaaga   Cagcagccct   Gatgatcagt   Tcttcctaaa   300     Gccatccggc   Tcctggggag   Aggcaggtgg   Gactccagaa   Ctcacagagc   Ttttgggagg   360     Gagaagagga   Ggccggagaa   Gcaaagggct   Ttacagcaag   Agaggtgtca   Gtcgcagcca   420     Ctggggaaaa   Gcccagaggg   Agggcagggg   Cgggaggagt   Gggcagagga   Tggaggccca   480     Gcccgggaag   Aaagtgggaa   Agggtgaccg   Ggtttttggg   Gtggggttga   Acgtgatgct   540     Tacgtttcca   Gaggaatctt   Ggcctgtccc   Cacgcagggg   Acagggaggt   Gcctagaagc   600     Agcagccaca   Ggagggccga   Ggtcttctgc   Acaaaggccc   Aggccacggg   Cattggctgg   660     Aggggaatcc   Agcggctgct   Ggagctgggg   Tttgcgagga   Agttgggagt   Tgcaggcatg   720     Gtgggcctgg   Ggttggggag   Gggaaggagg   Gcagagcagc   Cacagaccat   Gagctctgtc   780     Tgccttcctc   Ccagacccca   Ggacgcccca   Ggcctttgtc   Ttccgtgcct   Tggcgagcct   840     Ggggtctcca   Gcctctcagt   Cctgggtggg   Gagggcttct   Ctctgcccca   Cagctgcagc   900     Tcacagaaga   Gtcgccccac   Ctagcaagca   Ggcctcggag   Acagggactg   Ggggagaggc   960     Tgtggcaaca   Tgaaaccctt   Taatccgctg   Gcctctcctc   Taatcctctc   Ctgacagcag   1020     Ggagggggtg   Gcagggggtg   Gggagctgcc   Tcccaagatt   Accacaactg   Cagctggttc   1080     Cctcagggct   Atagtgcacc   Cctctgcttt   Aaagaggcag   Ccccgttcct   Gtggaaccac   1140     Cttctggacc   Caggaagggc   Ttgctgtgac   Tatggccaga   Ggacagcagc   Tgagtttgca   1200     Cagtactctg   Attgacccac   Aaatctcttg   Ttgaccctga   Ggtgggggtg   Tgtcctcatc   1260     Cctgcttggc   Agaggctctt   Gaggcccggg   Gagtcccagg   Ggcagagctg   Ggactctggc   1320     Tggtgtttcc   Aggcctggtg   Cctttgggac   Aggtcatagg   Tcataggtga   Agtcagtgga   1380     Cccacgcctc   Cacatctcag   Ctgctcgtgg   Gcggggctgg   Ggacgcattt   Gctgtgcaac   1440     Tgatgaagct   Tcaggacccc   Tgaatccaca   Gactcccccc   Tttcccggag   Aggccctagc   1500     Aatgtgttcc   Tgtggccaaa   Tgtttttgta   Aaatatgcaa   Aagttgagat   Agtttaacca   1560     Taaccggttg   Agactgtctg   Tctctttcca   Tcccaacttc   Tcttccgtct   Gagggactct   1620     Tagttggatg   Atgtttgggt   Ggctgagggc   Acttggggga   Tccagttaag   Aggaaagtga   1680     Gctggggaaa   Cacttaatct   Gggcttagtg   Ggatatgctg   Acatggttca   Cagtgacttc   1740     Tttgtacaga   Gaagttacct   Ccagctgagt   Gtaggcaggg   Cttccaggaa   Cactcatccc   1800     Acaggacatc   Ccaccagcag   Atgcagcaag   Agaggctggg   Ccgtgatgtg   Agcgcacgct   1860     Gtcacaccca   Ccctggccat   Gtgtggtggg   Gagggcaaag   Taacagtcag   Gagctcatct   1920     Gcagaaaatc   Tacaaaaagc   Cacacaggta   Acatcgttgg   Tggaggattt   Ggttctcacc   1980     Aaggcctggc   Caggacagaa   2000       <210>   7   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CBLN4     <400>   7   Ctagacatct   Gaaagtcatc   Aaaccctcac   Attcacacct   Caaggcaaaa   Aataataata   60     Ataataaatt   Ctcaccccaa   Actcaagcac   Caccagctaa   Accacggagc   Aggaacaaaa   120     Agaggggact   Caaagagaag   Ccacaagggt   Ggcgggtgcc   Cagcggcgcg   Ggtgccagtc   180     Ctgtctggct   Tgcggcaggg   Acgagttaca   Gaggcagaag   Gtccttccca   Ggctgagaag   240     Aacgcgaggc   Tgtgttcatg   Gccaggacgc   Cagcgactcc   Cactttcgcc   Tggtcaaaaa   300     Aatcccccaa   Acctggtgtc   Acccagaggt   Agggagggag   Gcagcggcta   Gccaggtccc   360     Tcgcaccgaa   Agcgcggatt   Cgcaggatca   Ggtccagggc   Gccgggcgca   Gcgttcaggg   420     Cggctggtcc   Ggcggggtcc   Tctcctgcct   Ggccgcccgc   Ccccagtccc   Tgcgcacaac   480     Tttctcgtcc   Ctcgtgcagc   Ccggagagcg   Cgaagcgggc   Acacgcgctc   Tatttatagg   540     Agcgcagcgt   Ccggctgggt   Tggcttatcg   Cgcaacccgc   Gggctccgag   Aaaaggggga   600     Gaaggcgtct   Ggtgacccca   Tctgagcagc   Tctctcctga   Cgtttaacgc   Accccaaagc   660     Aagcggggcg   Cacagcactg   Gtgattggca   Aggttcgagg   Cccctcagcc   Cctgaaagcc   720     Cgtggcgtaa   Agtaggcgtg   Cccagagagg   Agcccacggc   Cctgcgctgg   Ccccagctcc   780     Gcgcccactc   Tctcctgctc   Gatctgagtc   Cgcagaggag   Gcggctggtc   Ccctcacccc   840     Tcccagcgcg   Gaactctgcc   Gccgagtgcc   Ctccaagcgg   Agcgcggcgc   Tgccaggccg   900     Ggtcgcgaaa   Aaggataagc   Cgccgcggac   Ccgcgctgcg   Cgctgccccg   Aacctgggga   960     Ccggcgggcg   Tcccgaccgc   Gcctggccgg   Gaggcccccc   Cacacagccc   Tggggcctgg   1020     Cgagctcagg   Gaagccttgg   Ggcggaccag   Agcccgtggg   Ggcggctggg   Aggaggtgcc   1080     Tgattccttc   Cttccgctcc   Gggaagatga   Gcctcagaag   Ccgcaggggc   Gcgccttccc   1140     Cccacaccgc   Gaatcctccc   Caggcatggc   Caaaaaaaag   Agtgggagag   Ggagttaact   1200     Cagcaagaat   Aagtcctccg   Aaaccgtgcc   Aacaacaata   Aaaaaataaa   Aataaaaata   1260     Aaaataaaag   Acaatcccac   Tcctaggaat   Acagcatttt   Tctccccttt   Gtaggcgctt   1320     Tccgcccccg   Tgccactcca   Ctgctatctt   Ggcctctgat   Ttgcaagagt   Tcccttcctc   1380     Ttctgcagct   Accacgggga   Agggaggttt   Gtctctgtct   Ggacccggct   Gcgtgaactt   1440     Ggccgagtca   Ctaaccctct   Ctgagagggg   Ggcgcggcgt   Taactaaggt   Cctccccacc   1500     Cccatcccgc   Cagctttcca   Attctgtgat   Gctgtggggt   Catggcgccc   Cttccccaat   1560     Ttcttctaca   Cttccagctg   Cgagagggca   Gacacgtatg   Gtatctttaa   Ccaaaacagt   1620     Atcccccca   Ggcattcgga   Gctcctaaaa   Tggcattggc   Tagttatgaa   Tggaagggat   1680     Gtttattgag   Ggaggtcctt   Gggatggacg   Gctcccattc   Cttcctgagt   Gaaggacgcc   1740     Ctcatgagcg   Tggcattcga   Gccctccaca   Aaacaaggtg   Aacctcgtct   Ccagcctttt   1800     Tcccttcctt   Cagaagggcc   Gggcattgag   Ctatagagca   Cagctccaac   Tgttaaaatt   1860     Gaagacacta   Cgaggaatcc   Cctaacccctc   Acctccctat   Aatctctcaa   Ctaaagtgtt   1920     Aatacttggt   Gccacagggg   Ccttcagatt   Ctgctccagt   Ggggccagta   Tcaggtgttt   1980     Tgactttatg   Attttatttt   2000       <210>   8   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CBS     <400>   8   Gtttaccgcc   Accccacacg   Gtccgccaaa   Aagggcgatt   Tgcaaacagc   Catttcccat   60     Ccacaatgca   Gcgaactcaa   Tgctgggcac   Cgaaacgtgc   Atctcccccg   Gattcccacc   120     Ccgcgtccct   Gctccacgct   Ccaggactcg   Ccgccagtgg   Ggtccactcc   Gccggcgcgg   180     Gggctggggt   Gggagcccgg   Ggccacgtgc   Acggccagcc   Cccatcttct   Gggcggtcaa   240     Gaccgcaggc   Gtgggcgccg   Gtggggcggg   Ggtcttggga   Gaccctgtct   Cgccgccttt   300     Cggtgcagat   Gatgcaactc   Tgggcggagg   Cgcggagagg   Gaaaccggga   Cccagttgag   360     Atcctctgtc   Cagagagggg   Agcgagtctc   Ggtggggccg   Gatctcacct   Ggacggatac   420     Atggaaaaga   Ggggcgagcg   Gctgccccga   Ctgcggcgag   Gcggagacgg   Cgaccccggg   480     Gtggcggcct   Cgcggggacc   Cacggcgagg   Ggagcaggcg   Ggcggtgatt   Ggcggagagg   540     Cgggggcgga   Ggccggcgcc   Ggccaatgtc   Tcgtggcaga   Gcacccgccc   Ccccagcccc   600     Tcctccaccc   Cacccagccc   Gggcccctcc   Cccccacccc   Ttccccaccc   Cgccgcagcc   660     Tgggaccctc   Cggcctgccc   Gacccccccc   Ctccccggga   Cccgggcatg   Cccccacccc   720     Agtccgcccg   Ccccattccc   Acgccctgtt   Gattcaaccg   Cagacccggg   Tcgccgcccc   780     Ctcccccgcc   Ttcctcttcg   Cctgagcccg   Cccgccccgg   Gttccagcca   Cccccacccg   840     Cggaccccgg   Tggtgtcttc   Tacctggtgt   Tccgatgctg   Ttttacttgg   Ttaacttctt   900     Gcccttcggg   Aatttaagga   Acctttactg   Atgagcttga   Aacgtgcgtc   Ctggtgggtg   960     Gggggccctg   Cgcgtcctcg   Aggaccgacc   Cggagggcgt   Gtgtcgcggg   Cccgggaggg   1020     Ggcgccgcgc   Cggggcggga   Ctcgatggcc   Gcgctctgtg   Gccgccggac   Gccgtgcgca   1080     Gcgccccgcg   Tgaccgcgcc   Cagagccggg   Tccgaacccc   Gagccgaggc   Gcagaacagt   1140     Cgccttgcgc   Ggctccggtg   Cggcccacgg   Ccaggggctg   Ccgggcgctc   Tcggggacgg   1200     Ggccgactcc   Gcgcagggtg   Gtagcagggg   Cgccccgcgg   Ggctccttcg   Ccaggtcccg   1260     Gaggccgcgg   Gcggggccgt   Ttcccaaaca   Tcgtgctctg   Gactttcaga   Ggctgaacct   1320     Gatccccccg   Ccctatggct   Aaatggggga   Tcccaggccc   Ccgagtctcc   Cccgggacct   1380     Gcagcgaaag   Acacggacg   Tgcccatcag   Ctctgggcag   Aggaacgtgc   Tgcgcctccg   1440     Cagcgtcccc   Ggctcaggtc   Agagcgatgc   Tccgcagcct   Cctccggccc   Gcgcagctcc   1500     Gccgcggtct   Ctgccacgtg   Gggctcacag   Taggggaggg   Agtgagacgt   Gaattagaat   1560     Taaatgtcca   Ctggcaggaa   Ctgacacgaa   Gaacaataaa   Gccggcgatg   Tggggagggg   1620     Acagggtagg   Agttacatca   Tgaaggctct   Ggaaggtggc   Attggaggcc   Gggatcgcgc   1680     Cactgtcctc   Cagcctgtgc   Gactgagcga   Gactgtctcc   Agaaaaaaaa   Aaaaaaaaaa   1740     Aaaaaaaaaa   Aaaaatcctg   Tccagtcttt   Atagagag   Agacgtggac   Acagacacgc   1800     Ggagagaaaa   Aggccatgtg   Gagatggcgg   Cagagatgag   Atgtgctgcc   Accagacgag   1860     Aaatggcagg   Gatggctggc   Ggcctccaca   Gggctgggaa   Aggtggccag   Ggcctccctc   1920     Agagccttca   Gccagcctgc   Gggagagaaa   Gatgataaac   Ggtgttgttt   Ttgttgttgt   1980     Tgtttgagac   Agaggtctgt   2000       <210>   9   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CCDC105     <400>   9   Cccaaatcca   Taaaaataaa   Ttttttttaa   Aggctcttaa   Ttcttctagg   Gcaggtgaga   60     Gatgcccaaa   Agttaaaaag   Taaaccaata   Aatgaataag   Ataatttcag   Atagcggtga   120     Gtgctatgaa   Gacacgaaag   Aaaatgtaag   Actaagccag   Gcgtggtggc   Tcacgcctgt   180     Aatgccagca   Ctttgggagg   Ccgaggcagg   Agaatcacga   Ggtcaggagt   Tcgagaccag   240     Cctggccaac   Atggcgaaac   Cccgtctcta   Ctaaaaaaaa   Aaaatgcaaa   Aaattagctg   300     Ggcatggtgg   Tgggcgcctg   Taagcccagc   Tactcaggag   Actgaggcag   Gagaatctct   360     Tgaacccgag   Aggtgaagat   Tgcagtgagc   Ccagctcgca   Ccactgcact   Ccaggccaga   420     Cgacagtgca   Agactctatg   Aaaaaaaaaa   Aaaagaaaga   Aagaaaaaag   Aaagagagag   480     Agagaaaaga   Aaagaaaaga   Aaacgtaaga   Ctaaaaaagc   Tacttttggg   Tagtcaagga   540     Caccaagaac   Ccaggcagca   Aaaatctgaa   Gactgcaaag   Tggccagcca   Tgggagtatt   600     Ctacctgtgg   Gaacagcaag   Tcccaagctt   Ccaagtgtga   Aggcgcttcg   Gacaccctga   660     Agctgaaaga   Agggccatgt   Gctggaaggt   Aacggcgaga   Ggaatgcctg   Gtgagaagcc   720     Tggcccttct   Tccatgctta   Ccgacatgcg   Acagagtgtg   Acctggacag   Ctggaagcgc   780     Ttaggacatc   Ctaaagctgg   Aagaagggcc   Atgttgctgg   Aagcaacggc   Gagaaggatg   840     Ctagatgggc   Tctttctcaa   Ggagtcagga   Tgccagtgca   Cttaggccaa   Gttccaaagc   900     Aaagactcca   Tcctactcct   Cccccccact   Ctggaattcc   Acctcccttg   Ttgcgcccat   960     Cgctatggtg   Acgggcgctc   Tcagtacact   Gtctctacag   Gccaggaaag   Agttgtgtgt   1020     Ctttggggtc   Ccttccgctc   Cgcctagggt   Tcccggccag   Gccgagagac   Caagcaggga   1080     Ccatgcgcgt   Gttggtaccc   Ccggctgagc   Gcagccagga   Cacacgcgtt   Ggggccccag   1140     Catggcgcga   Ggcagctcag   Gccatggcga   Ggaccgcgca   Cattctgacc   Gatcgctgcg   1200     Ggcaggaggc   Ggtgaccatg   Tggcagccca   Aggacaggct   Gctggacccg   Aacgtggccc   1260     Accacctcgg   Ccgcgccgcc   Tacatccagc   Cctggcgctt   Ccgcgtggag   Atgatcaaag   1320     Gcggcggcac   Cttggagaag   Ccgccgccag   Gcgagggcgt   Cacgctgtgg   Aagggcaaga   1380     Tgaagccgcc   Cgcctggtac   Gcccgcctgc   Cgctaccctt   Gcaccgcaaa   Gcgcgcgccc   1440     Tgcagaccac   Cgaggtggtg   Cacgcgcacg   Cgcgtggagc   Gcgcctcacc   Gccgcccgcc   1500     Tcggccgcgc   Gcagcaccag   Attaacgggc   Gggtgcgaca   Gctgctgcgc   Cagcgcgagg   1560     Tcaccgacca   Caggctcagc   Gaagtgcgca   Agggtctgct   Tattaaccag   Cagagcgtca   1620     Agctgcgggg   Ctacaggccc   Aagtctgaga   Aggtgggacc   Ctcccccacg   Cccaacccca   1680     Gcctaactgc   Aaagactgag   Gcctccgcta   Tgcggtgtcc   Agccccggg   Aaatcctttc   1740     Catactttgg   Gaggccaagg   Ctggttgatc   Acctgaggtc   Aggaattcga   Gaccagcctg   1800     Accaacatgg   Tgaaaccccc   Gtctctacta   Aaaatacaaa   Attagccggg   Cctggtggcg   1860     Catgcctgta   Atctcagcta   Cttgggaggc   Tgaggcagga   Gaatcacttg   Aacccgggag   1920     Gcagaggttg   Cagtgagccg   Agatcgtgcc   Attgcactcc   Agcctgggca   Acaagagcaa   1980     Aactccatct   Caaaaaaaaa   2000       <210>   10   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CCDC140     <400>   10   Cagcggcctg   Ccgttgataa   Aaacaccgcc   Gagctggttg   Acgcggccct   Ggccgagggg   60     Agtggacact   Gtgggaaggt   Gaaaaagaga   Agcaagggaa   Aagccactgg   Aggaaaataa   120     Aaagcaaaga   Acagcagcac   Gtaatttcgc   Agtcttctgt   Cctatcctca   Tgttacagca   180     Ccgacgctga   Aactgctcga   Catcggactc   Ccagacccag   Acctcctttc   Aatcacattt   240     Gttcaaatta   Ttcagcaata   Tagcgcatgt   Aatcttgtgt   Aaagacagca   Aatggggcaa   300     Aataattctc   Cccagagaaa   Gcgtcttccc   Cttcgggccc   Ggggagtggc   Aacttaggag   360     Accctgcagc   Tggtagagag   Tctagcttgc   Tctagaaaca   Gcctcctggc   Gaagagaagt   420     Tcacccagga   Gctggccttg   Atgaactctg   Ctcccaccga   Tccctgtcca   Attgggatct   480     Ctccctttct   Aagggacttg   Ggccagctga   Tagcccttgg   Ggtttctagc   Caaaagtgca   540     Gcagccaagg   Gtcaaagagg   Gtccagaaag   Gaggcccaag   Cagcagtgcc   Tgtgtcacct   600     Gttacatctt   Gggacagaga   Ccacagcagc   Ggcagggctg   Ttcctgggcc   Cccagccccc   660     Attcttgctc   Tgggtgttac   Attctactct   Aggctgggtg   Tgaagggagt   Gggtggcggg   720     Ggcgatgagc   Atctctgctg   Gggcgcccta   Acctggaaaa   Ccattgaaaa   Cggctcaggc   780     Ttgcaagact   Tcctgcctcc   Ccgggattcc   Cagaatcttc   Aagtggacgg   Aaaggcgatt   840     Cctaaacaag   Ttatagaaac   Ttctagatgc   Tatttgagat   Acatagaatt   Ctaatttatt   900     Taattattct   Aaaaattcca   Atcacaatgg   Cgcggcgtta   Gccaccacaa   Ctttgcaggg   960     Caaaaaaaaa   Aaaatacttc   Ctgaactaac   Atatgtttca   Caagtgtggg   Cgcagccggg   1020     Acaatttcga   Gacaacttcg   Agacaatttc   Gaatggacaa   Attgcggaga   Agttgcttct   1080     Gccgctcaga   Agccggttca   Cctccttctc   Caccgcggca   Tttccaaaac   Aacagggaca   1140     Agtctccccg   Gctcgccgca   Ggcctgaccg   Cccagctccg   Ccaggatttg   Cagagagcag   1200     Cgcgctccat   Ttgcagaaag   Gaaatcgagt   Aggtcctcgc   Ccccgactgg   Tgcttcttgg   1260     Ggtgtggggt   Gcccagggaa   Tgggcttcct   Ggaagcacca   Aaggagcctg   Cggagcctgg   1320     Gtagggggtg   Aggcagccgg   Tcccaggccc   Tgggatccag   Gcggcgcgct   Gaggccctcc   1380     Cttaccttcc   Agcgggaacc   Cgctacgcgg   Gtagttctgc   Cccgggcccg   Gccgcatcat   1440     Cctgggcaca   Gcgccggcca   Gcgtggtcat   Cctgggggca   Gcttcgctcg   Gaaattatat   1500     Ccaggtgaag   Gcgaaacgga   Aaggcgagtg   Cggcgcggat   Gaccctcggg   Aactatccgg   1560     Agcgtggaga   Gcccctcccc   Aaaacggctg   Gagagagagg   Gagggacgcg   Gggagggggg   1620     Ctgtcggttc   Ctagtccaga   Ggccggagct   Ggaacccggg   Aaaggggagg   Acggggaggc   1680     Cccggagtcc   Agtagcccga   Gcccagggcg   Gaaaagtttg   Gtacgagtct   Gggcaaatgt   1740     Tccagcgact   Ggggtccctg   Aaaagggggc   Tcagagagcc   Acggcgagcc   Ggggagcctg   1800     Gtgaggctgg   Agcgcggcct   Gcctgagtct   Cctcctgtgg   Tgacaccgag   Tgcggggatc   1860     Cgggctcggg   Agcatttatt   Agttctttta   Cccaaagctt   Ggtcaggagc   Cctgagctgc   1920     Gattggccga   Cgggtagacc   Gtcccgggtg   Gcggagacac   Gcgctgattg   Ggcaacagcg   1980     Accactttct   Cttcccatct   2000       <210>   11   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CELF4     <400>   11   Atccccatct   Ttcaggtcgc   Tgtacccaaa   Aatccaagcc   Ccgtctcctc   Gatcccctct   60     Ctctttctct   Tcatcggcgc   Ccgctgctct   Ctccatggca   Tcgttcctat   Cagcacctcg   120     Cccaaaaccc   Agtctgccc   Cagcgaacag   Ctccccacgc   Accccagctc   Tggtctccgc   180     Tgcccgagcg   Cctccctcca   Ccgcgcccgc   Ccgaggcttc   Ctctcgctta   Gtccgccgct   240     Cgtcagtcgc   Cggccggccg   Gtcggcccgc   Cagcccgctc   Ctgctccccg   Gcaaagttgg   300     Gagggaaagg   Tgtactcacc   Tttgtgcatg   Cctgtgaacc   Tgtccttcag   Aaccgtaagc   360     Tcgtagattt   Tgccaaactc   Ctcgaagagg   Ggcttgaggt   Ccttctcatc   Caggttgcgg   420     Gggatctgcc   Caatgaacag   Cttgatggca   Tcgtggtcct   Tcatgggaat   Ggtcgacggg   480     Ttccccgggc   Tgtggcttaa   Tccgttcatg   Tgcccggcac   Tgcccgggct   Gctgccgagc   540     Ccgttggtac   Tgaggcttgc   Gttgtcagcc   Tgtccgtttg   Ctaacgtggc   Catctttata   600     Tacatagaga   Aaatcttctt   Tccttttatt   Ctttctcgct   Cacactctct   Cgctcctctc   660     Tctcgctcgc   Tcgcgctcac   Acacgcacac   Gcatacacac   Actcgggttc   Tctccccctc   720     Ggtttctcta   Cacctcgctc   Tccgctcgct   Ctctgctctc   Tctctttctc   Ctcttctctc   780     Gctcgctcgc   Gctcgcgctc   Tctctctgct   Ctccccccc   Tctctctccc   Tccctccctc   840     Tcctctctct   Ctccctctct   Ctctccctct   Ctctctccct   Ctctcctctc   Tctctcggtc   900     Tgatctgatt   Ttttttttct   Ttttttcttt   Tttttttttt   Tttttttttt   Tttacattga   960     Acagacagga   Tctctgtcct   Ttccgtttaa   Acaggctgga   Ccggttcaag   Ttcccagcca   1020     Gaccaggggt   Gggggtggcg   Agtgtgcgcg   Cgcggaggag   Ggcgcggggg   Gccgggaatg   1080     Ggcgcgctgt   Gggggcccgc   Gccacggcgg   Gcggcggccg   Ggggcagggc   Ggcgtggggc   1140     Ggcggccacc   Gcgcctcccc   Cgtcggcggc   Cccgcgccgt   Ggcgatggta   Cagtccgaga   1200     Cggcccccgg   Ctataaatag   Cgccaggcgc   Atggctcttc   Gggaggcgct   Gagattccgg   1260     Gcccggcggc   Cgcggggagc   Gggtgtccgt   Gaggagccgg   Gcagccggcc   Tcctctcttt   1320     Gccttttggg   Ggttcttttt   Gtaatagcag   Caggtgcaac   Tttttgtatt   Ttaaaaatag   1380     Tgatttttat   Tttcgtgtgg   Gtatgtaggg   Gggctttatc   Caccaagcta   Tgctctatta   1440     Gggcgccagg   Cgggcgaagc   Aaaggcaggg   Atggcgggcg   Gggcggcggc   Ggaggtggaa   1500     Tgggcgcttt   Tttcttccat   Ctggctttat   Tttattatttt   Agactagaaa   Agcgagccgg   1560     Cttggaggga   Gtccgcccgg   Ggatccgagc   Gcgcattcat   Cagtgtcgag   Gaagaaaaag   1620     Ctacataaat   Atatattatg   Tggataaatc   Tatagacaag   Agctctctcg   Cgcgcgctct   1680     Ctccctgtct   Ctctgtgtgt   Gtctttctct   Gttttttttt   Cctcctcgca   Cccccaacct   1740     Gccagagcag   Ccccacatct   Tcctcccgcc   Cggcatctac   Cgccacccaa   Gccacctgcc   1800     Agtaggggg   Tgggagctgt   Cgggccgcgc   Cggggggcag   Agggacgggg   Agtagagact   1860     Cggggtccga   Cccccgcccc   Aacccgcttc   Cgaaggcgga   Aggtgggggt   Ccccgtcccg   1920     Ggcggcctcc   Cccgccccgg   Agagcgcggc   Tggtcccccg   Gtggctggcg   Ggaggaaggt   1980     Aggagtcggg   Cgcccctgcc   2000       <210>   12   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CIDEB     <400>   12   Agtgacagcc   Tggggtgatg   Actttatgcc   Tgtttaccac   Tgagctctgg   Gaaggaggcc   60     Aggagtgggg   Caggtcaact   Gactgggagc   Aggggatctg   Ggttccaaga   Aggagttgtg   120     Tttgaggtgg   Ggtctgggtc   Ctcgtggaag   Tcaggactcc   Caggcagaaa   Agaggcaggc   180     Tgcagggaag   Taaggaggag   Gcatggcacc   Ttctcatcgg   Gcatcacagg   Tggggttttg   240     Ccccacccct   Gaacgccctc   Tgtggcgcct   Tccacccacc   Tgtaggccca   Gaaggatgtc   300     Ggtctgctac   Cgtcccccag   Ggaacgagac   Actgctgagc   Tggaagactt   Cgcgggccac   360     Aggcacagcc   Ttcctgctgc   Tggcggcgct   Gctggggctg   Cctggcaacg   Gcttcgtggt   420     Gtggagcttg   Gcgggctggc   Ggcctgcacg   Ggggcgaccg   Ctggcggcca   Cgcttgtgct   480     Gcacctggcg   Ctggccgacg   Gcgcggtgct   Gctgctcacg   Ccgctctttg   Tggccttcct   540     Gaccgggcag   Gcctggccgc   Tgggccaggc   Gggctgcaag   Gcggtgtact   Acgtgtgcgc   600     Gctcagcatg   Tacgccagcg   Tgctgctcac   Cggcctgctc   Agcctgcagc   Gctgcctcgc   660     Agtcacccgc   Cccttcctgg   Cgcctcggct   Gcgcagcccg   Gccctggccc   Gccgcctgct   720     Gctggcggtc   Tggctggccg   Ccctgttgct   Cgccgtcccg   Gccgccgtct   Accgccacct   780     Gtggagggac   Cgcgtatgcc   Agctgtgcca   Cccgtcgccg   Gtccacgccg   Ccgcccacct   840     Gaggctggag   Actctgaccg   Ctttcgtgct   Tcctttcggg   Ctgatgctcg   Gctgctacag   900     Cgtgacgctg   Gcacggctgc   Ggggcgcccg   Ctggggctcc   Gggcggcacg   Gggcgcgggt   960     Gggccggctg   Gtgagcgcca   Tcgtgcttgc   Cttcggcttg   Ctctgggccc   Cccacccacc   1020     Agtcaacctt   Ctgcaggcgg   Tcgcagcgct   Ggctccaccg   Gaaggggcct   Tggcgaagct   1080     Gggcggagcc   Ggccaggcgg   Cgcgagcggg   Aactacggcc   Ttggccttct   Tcagttctag   1140     Cgtcaacccg   Gtgctctacg   Tcttcaccgc   Tggagatctg   Ctgccccggg   Caggtccccg   1200     Tttcctcacg   Cggctcttcg   Aaggctctgg   Ggaggcccga   Gggggcggcc   Gctctaggga   1260     Agggaccatg   Gagctccgaa   Ctacccctca   Gctgaaagtg   Gtggggcagg   Gccgcggcaa   1320     Tggagacccg   Gggggtggga   Tggagaagga   Cggtccggaa   Tgggaccttt   Gacagcagac   1380     Cctacaacct   Gctgcccttc   Cctgtccctt   Tccacccccc   Acccaccctc   Cagaggtcag   1440     Tgttctggga   Catttgggga   Cccttctttg   Actagagttt   Ggatctggct   Gggtaggatt   1500     Actatacact   Tggggcaggc   Ccaggctcct   Ccaaactgag   Ggattatgag   Ggtggtgatg   1560     Gtccctgtta   Aggactattg   Tgtgcttgca   Agttggcatg   Tacccatgtg   Ccagcattgc   1620     Ttacttgttg   Ccaatagctg   Tttatgtgaa   Atacactggg   Aagccattag   Atgatgactt   1680     Aagtgtgctt   Cccctggtgg   Ttcttcatgc   Ctgagttgta   Ctgaagccac   Ctagttccct   1740     Gctgggtcaa   Gccaggctgg   Gcagtgccag   Ccttcagtgg   Catcttgacc   Tgccctcctc   1800     Agcccaggtg   Ccctggttcc   Acaggccaac   Ccatagaacc   Actctggaaa   Taaaggagaa   1860     Aatggaagga   Gaggtatggg   Agcttggatg   Aggggtagga   Atgggatcca   Ttctctgagg   1920     Cttataaaag   Cctctgagga   Ggaaatggct   Ctgaagggga   Aaatgaatct   Gtggggtttg   1980     Aaaaggaagt   Tttcctgcct   2000       <210>   13   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CKB     <400>   13   Ctgcagtgcg   Gggggaggca   Gaagccacg   Atgctgcggc   Ccgtgcgcac   Ccgcgagctc   60     Agcacgtagt   Tggggtccag   Gtcgtcgccg   Ccctgggagg   Cgagacggga   Gtgagcgccc   120     Gaagaccccg   Gccccgcccg   Cccggcccgc   Ccgcagcccc   Gcacctgcag   Gttgtcgggg   180     Ttgaggtcgg   Tcttgtgctc   Atcgctgggc   Ttgtagccgc   Cgtgccggtc   Ctcgatgatg   240     Gggtcgaaga   Gatccttgaa   Cacttcgtag   Gactcctcgt   Cgcccgccac   Gcagcccacg   300     Gtcatgatgt   Acgggtggcc   Tgggggaggg   Ggcgcgggac   Ggggacagtg   Acgtcactgc   360     Cgggcccgag   Cgcgctgctg   Aggaccctgc   Ggctgcgcgg   Ggggaggggg   Ggccgggacc   420     Ccggccccga   Ggggtcgcgt   Acccgggttg   Tccacgcctg   Tctggatgac   Gtcgtccagc   480     Gtgaagccgc   Tcggcgtgct   Cttggcgcgc   Agctccgcgt   Acagctcggg   Ggtcagcacc   540     Ttggccatgt   Ggttgttgtg   Ggcgctcagg   Tcggggaact   Cgtcctcggc   Cgggaagcgc   600     Agcttcagtg   Cgttgtggct   Gttggagaag   Ggcatggcgg   Cggcgggctg   Cggggagacg   660     Cggggtcaga   Ggggaccggc   Acgccggggt   Tcccgggctc   Ccgcgtacca   Ctcaggcccc   720     Cgccgccggg   Ccccccggcg   Ccccccggga   Cgcggccaag   Gtcagcgggg   Tccgcagcgc   780     Gcgcggggag   Cgccatcatc   Gccggggacc   Cccggccggt   Ccggcgcgcg   Ctccaggcga   840     Cgcgccccct   Ttgcacgcag   Cgcccctagc   Ccgggcgcgg   Acgcccccgg   Cccccgggcc   900     Cactcaccgg   Gcggccgggc   Gggggcgggg   Gcgctccgtc   Cgtcggcagc   Tcccggagcg   960     Acgcaggcga   Acagcggccg   Ctccgcgctc   Ccgcggctct   Taaggggcac   Aacgcgggcc   1020     Gcccattggc   Ggctatttat   Agcccattca   Ttccattggc   Ccgcgccgcg   Gggtggtgcc   1080     Gccgctttgt   Ccgccgcccg   Cagcccccaa   Caccctggcc   Gcccacccga   Gctgtcccct   1140     Cgctgggacc   Ccgcgcagcc   Tgcccagtcc   Cccgcccaag   Acctcgaggc   Cgaaacctca   1200     Ggtccttgga   Tatctggatc   Ccctcgcacg   Cccttgcctc   Tgggcgggaa   Actgaggcgg   1260     Agagcctccg   Ggcactcgag   Gacgcttggg   Ttcatccgca   Tcctcgagcc   Tgcccgccta   1320     Gtccagccag   Cccccgcggc   Ggcggcgagg   Ggccgggcga   Aagctttcgg   Ggcttccgca   1380     Gcaggtacgg   Cccccgcccc   Acccccggcc   Agtgcgagct   Ggcccggagc   Cgccgacctt   1440     Cctcaaggtg   Cccgcaggcg   Tttcctgggc   Gatcctggtg   Caaagcgaag   Gcgcgcggga   1500     Agcgcagtct   Ggctgcggcc   Cagcccgggg   Gcacccgcgg   Tgccctgacc   Ttggacaagt   1560     Cctgggtctc   Ggggggctgc   Gagccagaaa   Ccagggggac   Gctgtggcct   Taagaggccg   1620     Ctggcaagtg   Cagcctcgga   Gtttccagac   Cccaaccctg   Ggccctcttc   Gcaggggaca   1680     Agtttacccg   Acccccaaag   Gcagtccccg   Gagacttcag   Gcaaagatgg   Gaggaaacgc   1740     Taataaacaa   Taagcataag   Tgcgattaaa   Aaaaaaaact   Gatctcacga   Ataaccagaa   1800     Tcatgcaaat   Taagcagtga   Ctccacctgc   Ccctaccccc   Aacactccca   Gatcgacccc   1860     Agccattgct   Ggctttgagc   Tggaatgcgg   Gaagacaggc   Gtccacacgc   Tgcctgcaac   1920     Ttaaattgct   Gcatgctttt   Tgcaagataa   Tttggcagaa   Tctattaacg   Ttaacaatgt   1980     Tcgaactccg   Tgacccagca   2000       <210>   14   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CNTNAP5     <400>   14   Taattgtaag   Cttcaaatag   Gataaatcat   Tatggtccct   Cattttgtta   Aggtttgaca   60     Gctttctgac   Agcttccaat   Aaaaacaaaa   Taagttgatt   Tatgataaag   Caggagagtt   120     Tccagatata   Tactagaagc   Caaaaacaga   Aacaaaattt   Gtaagcgggg   Gtgtctagaa   180     Agaaaccaaa   Atcattcttt   Ccctttttca   Aaattcaaat   Ccctccagca   Gagcccttat   240     Attttggatt   Cttacgagct   Aacccgggct   Tccaccctga   Ctctcatcac   Taccacaccc   300     Atgtgtcttt   Cctctctccg   Tctccctgag   Acgccagtga   Accacctggg   Cttggaatcc   360     Agagccccgg   Aacaccttgc   Agtacttgcc   Cgaagcaacg   Cgccaacagc   Gggagggaga   420     Cgcagacgcg   Aagaccggcg   Agaggatgtg   Cggtgggagt   Agctgcgggg   Tctgcaagca   480     Ggggagcgcg   Cacaacgtta   Aaccttgaaa   Cgagaaatcc   Cgatcctatc   Gagacccatc   540     Agcttttccc   Atttgggaac   Gagcgcaggg   Gaaattaaat   Gcgtaattca   Agctctgttt   600     Tcccctcccc   Tccaaaggtg   Aggtggggga   Acgcgtctcg   Ttagctcatt   Acaaagcttt   660     Ccgtgggaaa   Ttccctcttc   Ctaatgcgtc   Tgtcttgcaa   Ctcctattag   Catccttcga   720     Cagcggcctt   Tgaaaatctc   Ctttaaattt   Caatacctct   Actcgtttcc   Caaatggggg   780     Gaagggaaga   Gaaagccggg   Gggtagagag   Aatttccttc   Ccctttccct   Cccaggtagc   840     Caaagcgcac   Cgcagcggct   Tggcttcctg   Gaggaaaagc   Gcccgagcgg   Ggcaaagacc   900     Cgcccaggct   Gctcttatag   Gcgagcgcgg   Ggcgggcctg   Gctgggggcg   Gtgccgcgcg   960     Gccccgctcg   Cctataagga   Gctgtccgcc   Acccgggtgc   Tgattccagc   Tctcgcgccc   1020     Gacgaggtgg   Atttggctgt   Ccaccgagct   Ccggcgcctg   Tcgttctaat   Tgggtttgga   1080     Tttgcaccgt   Taaggagggg   Ggaagagaag   Gaagaggcgg   Gcgaggaagg   Cgagtccagc   1140     Tagcggctgt   Tgcggggacc   Gtagccccag   Ctgcagctcc   Gaagaatccc   Ccgccacggt   1200     Ttcggtggag   Cgtctgggca   Cgggatggag   Tgaaagagcg   Agtgcctctc   Caagcggggg   1260     Tgggaggggg   Tcaggctgtg   Cagaggagag   Agacagcgag   Aagaagccgc   Ggctggctac   1320     Tgcgaatttg   Ggattcgatt   Gggagggacc   Gctcactcgg   Gggaaatgga   Ttctttacca   1380     Cggctgacca   Gcgttttgac   Tttgctgttc   Tctggcttgt   Ggcatttagg   Attacaggc   1440     Acaaactgtg   Agtacgagga   Gctgggggcg   Ggaaggtgag   Gtggaaaacg   Atcgcattca   1500     Gaaagacaat   Caactatcta   Agcgtactcg   Attgtgtctg   Ctttgggcaa   Aggaaacgga   1560     Aaaaaaatgc   Tgatcagtgt   Ggttccatca   Ctccaaccat   Cccaaaagtt   Agtagagctc   1620     Aaatgagcca   Accgtgctgg   Atttcctccc   Ttcttccgtt   Atcgcaaagt   Tcaagggata   1680     Aggaaaggtt   Tctcttccct   Taacctcctg   Ctagctccgc   Gttccatgcc   Tgcctgatct   1740     Cagccagtgc   Tttttccgga   Gaagggcccc   Tggttcagac   Agaatgcact   Gggagctgag   1800     Cttcctggga   Tggagatgct   Cccagccacc   Gtgctcggtg   Acagtggctc   Atctctgaat   1860     Gcagtgcctc   Ggatttgcag   Tataccaagc   Accccacgat   Acgtggctct   Gcgttctgcc   1920     Ctaggcagaa   Ggctccagtt   Ggggtatctt   Gcaaccaatg   Ggcaccggtt   Taacaggatt   1980     Gggagttttg   Gcctaagagt   2000       <210>   15   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   COLQ     <400>   15   Ccctacaatt   Ttccttcaat   Ccccacaaca   Aaccttgaaa   Gacaaattct   Gatcctaaaa   60     Gttgcacgta   Atttgaactt   Ctctgaaaga   Acatggtaga   Gtttgccttc   Tgctgtatgt   120     Ccctgagcag   Gcaaggatac   Aacctacaaa   Gaacaatttg   Tggtttggtg   Gctgtgcctc   180     Tgagccaaat   Tacccaaggc   Agtccactca   Agaggttaggg   Agactgtctc   Agccacccaa   240     Cgccagcggg   Ggcccagact   Acagaacacg   Attttacttc   Aaagccaagg   Taccagctgc   300     Cagccaaggt   Accagctgcc   Agcacaaggt   Acttgtgtca   Gtcaaggtca   Caagagggac   360     Acagacaagt   Gcacacaccc   Gttagcatgt   Atgccaggtc   Cccaccaact   Ctactgtgaa   420     Acccctttgc   Attgcaactt   Caacactggc   Tgagcagttt   Aaaatttaaa   Ggctttcaca   480     Atgagaaaca   Gccctgtgaa   Gagaaaactt   Aaaaagaaaa   Aaaatttaaa   Ggctgctaaa   540     Acctcctagt   Acagtctgct   Ttccaagagt   Cttttttcca   Aaacaatgca   Tgtgcatcca   600     Cacacacaca   Cacacgtgca   Cacacgcaca   Cacaactcac   Ccaagcagcc   Tgccgagtaa   660     Cagagcagtc   Ctgaaatgat   Gagcagatga   Gcgaggctga   Atgatgagcc   Cgtcattgtg   720     Aggcagggcc   Caaagcggac   Tggccaggga   Acactagccg   Gagacaggct   Gagattcgtc   780     Acgcctctga   Gtgctcccag   Tgcctggcct   Gtttggcatt   Aggggtggga   Gttggccaat   840     Ccctgctttg   Atgttgcttc   Tgctccagat   Gccaggggtc   Tggagccagt   Cctgagctcc   900     Tgggagtagc   Aatgggtagg   Cagccctgct   Ccagctgccc   Atgaacactg   Ctgtagggga   960     Ggcttggagg   Acaagagtgc   Cttcagccca   Ggggaggata   Tgaggttggg   Agcccaggga   1020     Tacttatccc   Cctgcaagcc   Aagaggaaat   Tgagagcaat   Caaacaggct   Gcttttcatt   1080     Tggctcaaaa   Accgacttga   Ctcaaaatac   Cacagcagta   Ttgactgctc   Tggtaagcct   1140     Caaagtcaac   Cccccaccga   Gaccgtccaa   Ggggagcctg   Ccctcctctg   Cttcagggaa   1200     Gaccttcatg   Gccaggggtc   Tcagctctaa   Tcctgtctgg   Gccaaagtgt   Tgctgacaaa   1260     Gctaaacgta   Actaaaacaa   Caacaacgaa   Accacaaaca   Aacaaaatat   Atagatttcc   1320     Aaagggcatg   Taggcaagtc   Tttttggatg   Aagcggcata   Taccagttac   Atgcttaaat   1380     Ctatctggta   Ctttataggc   Acacccagtg   Cacaagcatg   Gacacacaca   Atattttaga   1440     Ttataaaaga   Caagattatt   Attatactac   Ttagcaataa   Gcactgttgt   Tttgatcagc   1500     Ttagtaaaga   Ccataagcta   Tagcaggagt   Cagcaaactt   Ttgctataaa   Ggtcaacata   1560     Gtaaatattt   Aggctttgtg   Ggtcacatgg   Tctccgttac   Aacctcactt   Tgccattgta   1620     Caggacagca   Gccatagaca   Atacatgaag   Gaatgagatt   Ggtcatgttt   Tgtaaaagtt   1680     Tacacaaata   Taggaggcag   Gctggattcg   Gcccacaggc   Tgtagtttgc   Caagccctgc   1740     Actataacct   Tcaaaagaaa   Ggacacttat   Gttcattcat   Tcatttactg   Ttttattcat   1800     Tcagaaacac   Agtaagtacc   Aaattgtgca   Agacataatg   Actagacaca   Gttcccgccc   1860     Ttggaatgtg   Tcgttcagtg   Tcacgggaag   Agtactggcc   Ctggagtcat   Ccaagttggg   1920     Cttaagtcct   Ggttttgcca   Cttagtagct   Gtgtgacctt   Gaggaagtta   Ttcattcttt   1980     Cggagtctaa   Gctttcttac   2000       <210>   16   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CYP26C1     <400>   16   Gagctgtcgg   Agaatctcgg   Ctgcgctatc   Cctcctgggc   Ttttgcgatg   Ccaacgcagg   60     Cgtcgacgac   Tgcagtttcc   Ctgaaatagt   Cggagcaaag   Gagagaaaag   Cccagttctt   120     Tcaccttgga   Gtggcgagag   Aaaggcacct   Agaagctcga   Gggcggggac   Ggcagaggga   180     Gccagcggcc   Gggggtgggc   Caggagcact   Gcggggcgca   Agcccgggtc   Agttctgcgc   240     Gttgggttcg   Cccactttct   Gagcgcctgc   Gaagagcggg   Gaagctctgg   Cgcgaacccg   300     Caggccccgc   Ccgaggacgc   Tcgcggggcg   Agcccccagc   Ccagctcgag   Ccgccccggc   360     Gcctgccact   Ccctactcag   Agcccccccc   Tgagcgcgcc   Gctgcccacc   Gcctccaatc   420     Accactctgc   Gtggagcgct   Ttaaatatgc   Aaagacacgt   Cacgttgtgt   Gaaccgggat   480     Cggtccgtag   Ggggggagcc   Aatatctata   Taaacgtgtc   Cagcgtgggc   Caagaagggt   540     Taaacgactg   Gaggagggac   Aggtggggcg   Ggggtctgca   Gaccaggttg   Gcaacactgg   600     Tgagttgctc   Ttctttcgcc   Ctccttccct   Tcttctatcc   Aaagggtgct   Gagcccggga   660     Ggaggtggga   Ggtgccccgc   Ggagccggga   Gtgagcgttc   Ccgaggcagc   Aggcaccttc   720     Gagagggact   Ggcatttggg   Cccaggagcc   Aggaaaaagt   Cctgagcgtg   Ccggcctcga   780     Ggaaggcacg   Ttccctaagg   Gcgcacggtc   Actgcagtct   Ttcaccgtcc   Gtctgttttt   840     Agaacagagt   Tctggcctga   Gcttataaat   Ctcgggcttt   Gcccccaaac   Cccaggcctt   900     Ttgcggacgg   Aacaggtgag   Cactgcgcac   Tgctcgcgcc   Ccggttcttg   Cgtcccctgc   960     Tctccctgcg   Ctctgagcgg   Cctggccccc   Gcgggctcat   Catgttccct   Tgggggctga   1020     Gctgcctgtc   Agtgctgggg   Gcggcgggca   Ctgctctcct   Gtgcgcgggc   Ctgctgctca   1080     Gcctggccca   Gcacctctgg   Accctccgct   Ggatgctgag   Ccgggaccgg   Gcctccaccc   1140     Tgcctctgcc   Caagggctcc   Atggggtggc   Ccttcttcgg   Cgaaacgctg   Cactggttag   1200     Ttcaggtgag   Cagtccttcg   Accccgagcg   Ctaatacggt   Cccttcttcc   Cccggctccc   1260     Actggaccct   Cctcagtctc   Aatgcccatg   Ggatttgtag   Ccagtccctg   Cccatcgccc   1320     Acgaccccgg   Gaagcgcgca   Caactctcgc   Ctttacctag   Atactccgtt   Ccctcgaagg   1380     Gacctcaagt   Cactggaatt   Ccccccagag   Caactcccag   Acacaacgca   Gggggtaaac   1440     Ataaggggtt   Ttaggaaggg   Gtctgaggag   Cacgtcctgc   Aagggtagaa   Aaggagcctg   1500     Gagcttggcc   Cagctgtgag   Cccttgggcc   Ctcacttctt   Cactctgagt   Ctgtttcctc   1560     Atctcaccaa   Taggaacagg   Agcatgtaca   Ttcccgtaga   Gtagatacca   Ggcccactgg   1620     Ggatcttgtt   Ttgtaaacgc   Gccagccagg   Gacaggaagt   Tgtgatcaaa   Aggcagctgg   1680     Aaggtctggg   Tcagatccca   Gcccaggccc   Agaagttcca   Gctctccacc   Ctccgcctcg   1740     Cccgcagggc   Tcgcgcttcc   Acaggtctcg   Ccgagagcgc   Tatgggacag   Tgttcaagac   1800     Gcacctgctg   Ggcaggccag   Tgatccgcgt   Gagggggccg   Gagaacgtgc   Gcaccatcct   1860     Gctgggcgag   Caccgcctgg   Tgcgcagcca   Gtggccgcag   Agtgcgcaca   Tcctgctggg   1920     Ctcgcacaca   Ctgctaggtg   Cggtcggcga   Gccgcaccgg   Cggcggcgca   Aggtgagtgg   1980     Aaacgggaat   Ggaccgtaga   2000       <210>   17   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   EFS     <400>   17   Ccccctccaa   Accttttact   Tgcctcccaa   Ccacaagcct   Ctgccaacca   Ccagtggcca   60     Tctgttcccg   Cccaaaagga   Gcagatagga   Ctcgggctac   Gcttgcccct   Tcccctccat   120     Tcaggcgcag   Cctctaggaa   Gaaaaaggag   Aatggggagg   Gggcggggaa   Gaggggcgag   180     Cccggagcca   Ggaggagcag   Gggatgagga   Gtgagaggga   Gaagggaaac   Aaaagtgaga   240     Ggagggggac   Acagccctcc   Ggagaagaaa   Gggaccaagg   Agagagacaa   Agagagggca   300     Gaaataaagt   Gacaggagcg   Cagggcaggc   Cgtggaggtc   Tctccccggc   Agcctccact   360     Ccctggtgga   Ctcaccgacg   Tggcaatggc   Catggctttg   Gcctcccgcg   Cagcctgcct   420     Caggccaggc   Tcggttttgc   Tgacttcagc   Ggtggctgcc   Ccgcaccatg   Gtccgcggcc   480     Tctagccccc   Agctgtggcg   Cctgagtcgt   Ggcctccgcc   Aaggttggag   Gaggagaaag   540     Aaaacccaca   Aaacttccca   Aatgagaggc   Aggctagcca   Ggcaggagga   Ggagcggggc   600     Gggccggggc   Gtcgctgcgg   Gacggcatcc   Aagggcgcgc   Gctgcgtgct   Gtccccgcgg   660     Cctcccgggc   Gccaccggct   Cggccaggcc   Ccgggagctg   Cccgccctag   Gccgcggggg   720     Cgccccgggc   Tcgcaggatc   Cgaaaattcc   Cttcccgggc   Cggggcgggt   Gagcaggcgg   780     Gcgctgggct   Gcgctcgacg   Cctctccagg   Ccgctcagga   Gaggctcgag   Ggctgggaga   840     Agccgccggg   Gcggttgggc   Tggacgagcg   Agttagggg   Ccaaccgtct   Ccaccccccg   900     Gccgcgctgc   Agagcggtgc   Tcccagggct   Ggggtctgcg   Gcgaccccgc   Tgggaggaag   960     Ggagagcgag   Aactgagacg   Cttgccccaa   Gttgcctgga   Gccaaaggcc   Cccgagagcg   1020     Tggccgtggg   Gctgggtcgc   Tggagtggcc   Gcttcggccc   Agacactcgc   Acccccggcg   1080     Gtgcggcggt   Tttcacgcgc   Gcactcactc   Agcgcgcccg   Ggggtctgag   Gtcgccgcta   1140     Cggcgcctcg   Ccccgggcag   Cagcaaccag   Cacgcaggca   Cccctggaac   Aggcgggact   1200     Gccttcccga   Cgcgcggcct   Gcgcccaggc   Ggcggagggg   Cccagccccc   Ttccagtcct   1260     Cggctccagg   Gcgcagggcc   Acgagctccc   Gctcccaccc   Tcggcccctg   Gcacccggcg   1320     Ccggctccgc   Cgccctctct   Cacacgcacc   Cttggcaggg   Ccccgcgggg   Cgccccaaag   1380     Cttgggggca   Gctcccaggt   Gtctctggga   Agggaaagaa   Aggccacaaa   Gcaaaagaag   1440     Gagcaaagag   Aaggcgaggg   Aggaggaggg   Gcccgggtcc   Tgtggactcg   Cctgggctgg   1500     Gagtggggac   Actgagaggg   Ctgcgaaggc   Tccgggggtc   Gcgcgtggcc   Cgcaggctca   1560     Cccctggccc   Gcggctgccc   Ttccctcccc   Ttcctgggct   Cctggcccct   Ctcagtgctg   1620     Ttcctttctc   Ctcccctcag   Gccctctcct   Ctcccgcgca   Gggctccgtc   Ctggggatta   1680     Agagaaagga   Gggaggggaa   Aggggagggg   Aagggaaggg   Gcggaggaga   Aagagggacg   1740     Atccttccaa   Aggcgggtgt   Tgagtttcag   Ctcaggaccc   Tcgggtccaa   Ctgcctgtgg   1800     Taccccccac   Accccccacc   Cccgtcccgc   Cctggccctg   Ccccagtccc   Cggcgccttc   1860     Ctcctccgga   Ctccgctgca   Tgcctcgctt   Gcggtggtcc   Gatcggcttt   Ctccgggagc   1920     Tttcctctcc   Ccgccacgcc   Cccgtctccc   Cggccgtccc   Cgcgcctctc   Ggcctccctt   1980     Tcattagccc   Cacatctgtc   2000       <210>   18   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   EMILIN1     <400>   18   Taagaaaggt   Tctttctctt   Cctgcccacg   Tgccctctac   Cgcttgacag   Aagcctgctc   60     Cccattgcca   Ggtgcttttc   Ttcctcctcc   Tcttcttctt   Tttttttttt   Gagacagagt   120     Ctcgctctgc   Cgcccaggct   Ggagtgcagt   Ggtgtgatct   Tggctcactg   Caacctcctc   180     Ctcccgggtt   Caagcgatta   Tcctgcctca   Gcctcctgag   Tagctgggat   Tacaggcgtg   240     Tgccaacatg   Cctggctaat   Ttttgtattt   Ttagtagaga   Tggggtttca   Ccatgttggt   300     Caggctggtc   Tcgaactcct   Gaccttgtga   Tctgcccacc   Tcagcctccc   Aaagagctgg   360     Gattacaggc   Gtgagccacc   Acacaaggcc   Ctttcttcct   Cttctgtcat   Ctgtggattt   420     Cccatctgcc   Tcagtggagt   Ccttgacctt   Ttcctccctg   Gcccagcagc   Acattctcct   480     Ctcctccttt   Ctcccaagtc   Actgacctag   Tatttagtgt   Gtgttctcag   Cctcaccatt   540     Gacttgctgt   Gttaccttgg   Acaagtcact   Ctcccactct   Gacctcaatt   Ttcacatctc   600     Taaaaggaga   Ctgctagact   Agacggtgag   Tgaagtcctg   Ctgagccctc   Cgagttcatt   660     Ctcccttgtc   Cagtcagtcc   Ttccctccca   Ccctcccctc   Tgggctccct   Ctctggggcc   720     Ctctccccca   Ggggaggcct   Gctccagccc   Caggggagct   Gcggccctgg   Ctcctgttcc   780     Cagtcggagt   Gaccagccct   Gggcctcctt   Cccagcttcg   Gccctggctc   Catgtggccc   840     Atctgagagg   Ctggcctcaa   Gcccggcggc   Aactccacat   Ttctgttttt   Cctttttttt   900     Ccctctttcc   Cggagttaac   Aagaagcaga   Tgtggcgcac   Gatggttgga   Gaggtggggg   960     Gaggaagggg   Gaggccggac   Cgccagccag   Acagggggga   Agggagggga   Gccagcaggg   1020     Aggaggaggg   Cagggcccgc   Cccacagcca   Ctctcgcgcc   Tccgaacagc   Cacaggggca   1080     Aagccctgtc   Acccccagga   Tccggtcatc   Agggaaagag   Gacagggaga   Cgagaagagg   1140     Gccagctggg   Acgagggggc   Ggacgcccag   Gaggcaactt   Ctgagacgca   Gctcctgaga   1200     Ggggcaggga   Ccaggcgcgg   Gaggccagag   Ggggcacaga   Gaacaaaccc   Cctcagaagt   1260     Gaagaggaga   Gcggaaggaa   Ccgagagggg   Acggacagga   Gctgaggagg   Aaagaggagg   1320     Ggagaggggt   Caggccaggc   Agccaaggag   Aagacgtgtg   Gccgggggct   Atcagaagga   1380     Aactgggacg   Gacgggccgg   Gctcgggctg   Tcctgtggag   Cagcagcatc   Cccggggccg   1440     Gcagaggcgc   Cagtggctgg   Gcgggatgag   Tctctgaggg   Ccactgtgga   Gcgccccgcc   1500     Atggcccccc   Gcaccctctg   Gagctgctac   Ctctgctgcc   Tgctgacggc   Agctgcaggg   1560     Gccgccagct   Accctcctcg   Aggtttcagc   Ctctacacag   Gttccagtgg   Ggccctcagc   1620     Cccggggggc   Cccaggccca   Gattgccccc   Cggccagcca   Gccgccacag   Gtaagagtct   1680     Ggatcccagc   Ccgaggcttg   Ggtggtgagg   Aaggggtcag   Aatgccacct   Ctgcctggct   1740     Ctctgctgtg   Tccgctaatg   Cagggcagag   Ggggagtgag   Aagcccatcc   Atcaggtggc   1800     Tcctcacatg   Cccaccttcc   Cacggggcct   Tttccaggac   Cccctgaaca   Catatgttcc   1860     Ttgggtcacc   Tagggggtcc   Gctcccacat   Gccccaggga   Agctgccctg   Aggggagcgg   1920     Gccaggcctt   Cctgccagct   Gccctctgta   Tcctagcccc   Agagcctcag   Ggagaacttt   1980     Tgtccccttc   Tagggctccc   2000       <210>   19   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FAM101A     <400>   19   Tgccacagtc   Tcacagactc   Aagcagaaga   Cacaagactc   Ctgggtcaga   Galacaaggat   60     Gttattactc   Acaataatca   Cagaagccag   Ggggtcagca   Tgttcttgag   Ccagttcccc   120     Agctctggtt   Tccacagggc   Cactagaagg   Ggcccaggtg   Acccttgcac   Atgcagctgt   180     Ttgcacgaca   Ggggagaaat   Ccagagtgta   Gggaacccga   Atctttcaca   Gtgggtaata   240     Agcctgcctg   Aacttttctc   Cagagggaac   Cattattttt   Attacagtgg   Acaggaagca   300     Tgcctatcct   Ttgatttgaa   Gagagacgct   Atctctacct   Ttcaaaactg   Ttctccctac   360     Aaacgttatt   Gaaatgatag   Cccagaatga   Agggcggcca   Aggcctctgt   Ttgcaagatg   420     Ggaataaaca   Cgggagactc   Atgaagaatt   Gtctcctaat   Agtgacaacg   Aaatgcaatg   480     Tgtgtgatcg   Cttctctgcc   Ttttggctaa   Gatcaagtga   Aatgcaacgt   Gtgtttgagc   540     Cctgggttga   Gaaagaaaac   Agctttaaag   Gacattgttg   Ggaaaattgg   Ggacattttg   600     Atatggaata   Taggttatat   Aattgtatca   Acgttaaatt   Ccctcagtat   Gatcgcggta   660     Ttgtggttcc   Atatcatctt   Tcttcttagg   Aggtgccgtt   Gaagagtttt   Ggggcaaagg   720     Ggcatgatgt   Ttccaccaa   Tttttacata   Gtttagcaaa   Acacaaaaca   Aaataaacag   780     Tacacacaca   Catacgagag   Agagagagag   Agagagagag   Agagagagag   Agagatccga   840     Tatgtcaaca   Ccacaacaaac   Ccaaatggta   Cttgggtttt   Cattacatta   Ttcttgcaaa   900     Aattcagggg   Gacccagctt   Cccccaagaa   Cacacagctg   Gctcttggcc   Aagcctggcc   960     Gggagcgacc   Ttcttctgac   Tttacggagt   Gtgttttcac   Tacactcagt   Ctctgatttt   1020     Atccctgccc   Tggcttaatt   Aagtgctctg   Aagacataaa   Taggtttttt   Gtttactcaa   1080     Gcttgggaga   Agctggcaga   Aaaggccttt   Tcagctaaaa   Gctccttaca   Gccggaaggt   1140     Gtgaagcggc   Aagtttccag   Ccgggaagaa   Gcctctcagc   Cgtaggcgtc   Tttgcccgga   1200     Gctgtgaggt   Gagtccagca   Gccccactgt   Ggagtgggaa   Cgggaggggc   Tgcgggaaag   1260     Ccaagccagg   Acgctgggtg   Gcagaccgtt   Agaacagctt   Tcattactca   Ctgaaagcac   1320     Tgggaatctg   Gaggctgtcc   Tggacacgca   Catacaaatg   Gcagcagaac   Gtatgcccag   1380     Gtcaaaggca   Ctttgaattc   Attttgtccc   Cgcttccctg   Tcttagtagg   Gcaggtggtc   1440     Aagagctggt   Tttatgagtg   Gacacccagg   Gcatgggccc   Tgacccccag   Acagctgccc   1500     Agcaaaggcg   Ggctgcaggc   Tccgagagga   Cacgggctaa   Aaatgaagag   Gtgagtcact   1560     Gctggagctc   Tgtccaggcg   Tggacatctg   Tggtacagct   Ggggactgag   Caagggcact   1620     Gcggaaaagt   Ccctcgggtg   Agacaggcca   Ccggggaaca   Tgcgactccc   Cggggcaggg   1680     Aggcatccct   Gggccaggca   Ctaggacctg   Gcctgctgag   Gatgcagagt   Cccaggtctc   1740     Acggttgtac   Agtcaccggg   Accttcactc   Tgaaacattt   Gaccacatgc   Ccggctggac   1800     Agctcagaca   Gggcctgtaa   Ggagcgtgtg   Atcaagaagc   Cactcttctt   Gcctctgttc   1860     Tcgccgcccc   Tttgaactcc   Tccacttcaa   Cttcttctgt   Ggctactttc   Aaaccctcag   1920     Ggatgttcag   Tgttacttct   Gcattcccta   Aaaataggca   Agagcccggg   Gctctcccta   1980     Ggaaagacaa   Agatttcgct   2000       <210>   20   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FAM115A     <400>   20   Gggagagaaa   Tcaagagaac   Ctgaattcaa   Gattctgcca   Agtcaaggcc   Cacctgagag   60     Acagtgagca   Catcttttat   Cttctccagt   Gttcagattt   Ttcagctaaa   Tgaagcgggc   120     Tagtgactgg   Cactcactaa   Gtcccttccg   Ggtctgcaat   Gtcaggacta   Acagcaccgc   180     Aagttaaaac   Cctgtaatac   Tgaatctcgt   Gcaaaaattt   Taaattcaga   Acaaaaacgc   240     Atacctaaaa   Ataaacatta   Ataataaagg   Acaaaatata   Caaggtaagg   Gatgcaagct   300     Aacttacctc   Tcaggatggg   Ggcatgagat   Ttggtggggg   Gaaggggttt   Ttaagtgttt   360     Tatttcttag   Aaagaaaggg   Gggtggagga   Agagagggag   Cgctgaagca   Aaggtgataa   420     Aatgtcagca   Tataataaat   Ctgtcatatt   Atctcctgcg   Cgtagctttg   Aaatatattt   480     Catatataaa   Taaaatatgt   Tgctggttat   Gttcctggag   Aagaaatgca   Gtatgaaaga   540     Aataagagac   Tggtagaaag   Aagctgaaat   Agaaacagca   Atggagaaag   Cgcaggcaac   600     Cctttttgaa   Agacatctac   Ctccctggac   Ccaaaaccca   Agggggtccc   Aggccaaaaa   660     Cgcgaccact   Ttggcagccc   Cgcgtgcgcc   Cccctcggcc   Gcgctcccca   Aggaccccga   720     Cccagtgcct   Ccttctccca   Cccgcacctc   Agcggactgc   Atcgggagcc   Gcccctgaat   780     Tggtccgtgt   Gcccgggcct   Ggtctggtcc   Ccgaaaccag   Ctttggacga   Gactcaccct   840     Ttcgtccagc   Aatttccaca   Ccaggctact   Ttggagtggg   Gagtcttcca   Cagagatgtg   900     Ggaaggcgct   Ggggcagacg   Cctgtggaat   Ttgcaaattg   Gtagtgaagt   Ggctaggagg   960     Aggcgtgtgg   Ggggaggtgg   Gctgcagtgc   Agacggttgg   Gggttggggc   Gtccccggga   1020     Gctgattggc   Tgccgcgggt   Ggaggcggag   Cttggccgcc   Gcccccggac   Cgcagaggcc   1080     Cggctttgtg   Tcagtttcta   Ccccaagatg   Ccgccccaga   Tccgggatgg   Agaccagac   1140     Gcccgccctc   Agaggcagc   Aggaggattt   Gtttcaaagt   Aaatcgttga   Gactgttcat   1200     Taacaaggga   Gcgatggata   Aataatgatg   Atctctgtgt   Aaaataatat   Acaactattt   1260     Ccaaggatgg   Gttaaatcta   Cttatataaa   Tctacttata   Tattgcctct   Atctatatat   1320     Ttatatatta   Tttttaaaat   Aaacatctaa   Catagtaaaa   Aacgttccat   Tttgtgtaaa   1380     Aaaaacttca   Aaactgttca   Tatgtactta   Tataaacaca   Gaaattgtat   Ggaagataaa   1440     Ctattagaac   Cagttacttc   Agacaggaaa   Gtggattact   Tgttattttt   Ttcttgatac   1500     Acctcattag   Cgtttcaata   Gtcacacgca   Tttattgtgta   Ataaaaataa   Atttaatcaa   1560     Ctaaaaaact   Acataaaata   Tcctcaccca   Agcagctggc   Agcggcttct   Ctacaaatat   1620     Gatttctccc   Tgtggagaac   Tttgttgcta   Gttctgatcc   Atgttatttg   Agtggaacac   1680     Gagacttgac   Catggagcag   Gaactggctt   Tatgcctgac   Caggtcctgc   Actcgcatct   1740     Actcatctaa   Cctggagagc   Tcaactgtaa   Aacctggagg   Aaccactcat   Ctctttttat   1800     Ggctggtccc   Cagggcccca   Gggagatttg   Catggcccct   Gtcctgtctc   Cagattcctc   1860     Acccctcact   Gccctggccc   Ctgtttgctg   Ggtacctaag   Gaagggttgt   Cctgggacca   1920     Aactgttctc   Tggaagagac   Catcacaaag   Ctttctccct   Tactacaaaa   Gtgtagtgtc   1980     Cagagtggac   Cttccagggg   2000       <210>   twenty one   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FAM49B     <400>   twenty one   Caggacacac   Gtttcaaagg   Acacacaggt   Ttttcccaac   Cccagtgtgt   Gtgtacacag   60     Ccccaggaaa   Gccctgcagg   Ctgcaagggc   Acccacccgc   Taacactgaa   Cttccattta   120     Aaaagaaaga   Taatgaaaag   Ataaaaggcg   Aagaggaagt   Gctctttaaa   Cacaggcggg   180     Tggctacccc   Aggaggaagt   Cttgaggcca   Gtggagattt   Tgttcacccc   Ctctagttcc   240     Tcaaatccaa   Tgcgactggt   Cttccaagcc   Cctgatggga   Ggtggccggg   Ggccagcgct   300     Gctcccgggg   Tcagtccccg   Caccgacacc   Cggctcgcag   Gaagggtctg   Ccagggacca   360     Gccaccccga   Cccgagcgcc   Ccctgcctcg   Aggcgcacaa   Ggcgccggct   Ccgcagctgg   420     Ggtgacccgg   Gcggcggccc   Cgctgcgcgc   Tcccctcgcg   Tccgcccgcc   Gccccccgcg   480     Cactcgaggc   Gcctcccccg   Ggacccccgc   Gcccgccggc   Ccggacgccc   Ccaccacggc   540     Ggcgccccct   Gtccacccgc   Cgcagcgccc   Ggcccggcgg   Cccggatggt   Acctccgcct   600     Ctccccgcac   Ccatcacgcg   Cgcgccccgc   Accccgcgcc   Ctctccgggg   Gcaaatcgga   660     Tccaggggcg   Cgcgcgcggg   Ccggccgggc   Ggcggcgcct   Tcagagcccc   Ggcacgtacc   720     Tggcggcccg   Ggcgggcgag   Gggagcgcgg   Cgcgggagcg   Caggagcctc   Ggagcctccg   780     Gtgccgccgc   Cgccgccgtt   Tccgggttgg   Cggggctcac   Gtcaccgcca   Caggtttgcg   840     Agctgccccc   Gccgcggcgg   Cagcagcagc   Agcagcagca   Gcccgggcga   Gtgccaggcg   900     Gagaataact   Ataaaaggaa   Gaggcgcggc   Gaggaggaag   Aggaagcgct   Gtttaccttc   960     Gagaagccga   Gccgccggcg   Ctcgcacaaa   Aggaggacgc   Tcgcctcgcg   Acgcgcctcc   1020     Ccccgcgccc   Agtccccgcc   Gcatcgcggg   Gccccggcgt   Cagcgcgcgc   Cgcgccccgg   1080     Gaccgccccg   Cgccggcccc   Caccccagaa   Ccccgcgccc   Gcctggcccg   Tgtcctcccg   1140     Agccggggcg   Ccacgggccc   Gggacggtgg   Tgaccttggg   Caagtcaccg   Cggggcgcgc   1200     Tgcgattggg   Ggtcatcgcc   Ctcattgtgc   Gaggaggaaa   Cccggctccg   Agaggcgcaa   1260     Gagtgacccc   Caaggtcact   Gcctgtcagg   Cagggcttgg   Gctcgaaccc   Cggtctccag   1320     Accttcaggc   Cggccaggtt   Cccatccctg   Ggtcgcttcc   Ccctcacctg   Gacttcagga   1380     Atggtgacag   Cccctgcctg   Gctcacctcg   Cagcggggtc   Agtgagagga   Atgctgtcca   1440     Cgcacccatt   Cagccctccc   Gcagatactt   Actgggccta   Ctaagtgccc   Gggctgttct   1500     Aggccctgga   Gctgcagctg   Cgaaccaaaa   Caaaatccct   Gcccgggagg   Ggcagcgggg   1560     Acaggccgta   Aatatctgat   Gggtcctatg   Gtgctaagtg   Ctgtgccaga   Ggaaaaataa   1620     Agcggggtga   Ggggacggtg   Cgggctgtcg   Gtgctaccct   Aagcggttct   Ccaaggactt   1680     Taaatttagt   Acagaaattc   Ccacataaaa   Agctcctcgc   Cataattcca   Gtttcaggta   1740     Tttagggaga   Cctcatcttt   Cccctgatct   Agaatggaaa   Atactgtgtt   Tttctccctg   1800     Taacaggaca   Tgcctaggaa   Actgatactc   Tccttccctc   Tgccttgctc   Ccctggccca   1860     Gaagcccatc   Ctatcattat   Cttgacattc   Aaccagaaat   Ttctcgggaa   Galatagaac   1920     Attctctcaa   Gtatctttct   Gctgtcctct   Agcagggtat   Caaaagggtt   Acatcaaagg   1980     Cttccattgt   Ctttccacct   2000       <210>   twenty two   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FBXL22     <400>   twenty two   Ttgagtcaga   Gagggcaggg   Gtggcccact   Ggcttctcca   Agagggaacg   Gaggggactc   60     Atagaatgga   Tggtgtgtgg   Tcaacttaaa   Ggcaaagatg   Gactaaaata   Ctgaacttaa   120     Aattgtttca   Agcagtttca   Cattaagagc   Tacctcatcc   Atcctgacat   Tttgggaagt   180     Acaggttata   Catagtacaa   Ggccttatca   Gtgagaaaat   Gtaaagccaa   Gtaaatttaa   240     Atttaaaaca   Cagaaagtac   Tgcttgacca   Aaactacaaa   Aacaacaaca   Acaacaacaa   300     Agcaccaata   Aaacataaaa   Cacagacaca   Caactttgga   Aagcagctac   Ttcagtaaaa   360     Ttcttttatg   Aaacaactca   Gggtaaaaat   Ctagctgttg   Gggaggccca   Ggaaaatccc   420     Cctgcctagt   Ggcaggcagc   Agggcttgaa   Ggccaaccag   Cctagcctgg   Agacaattac   480     Tctatggcac   Aaaaataaca   Ggaatgaggc   Agcagccatg   Gactctgctc   Acaactcaca   540     Accgtcaccc   Ttagctctcc   Acacgcaaca   Ggtttcttcc   Tagtaagggt   Ggagcaaaag   600     Attcacactg   Atgtactaga   Aaatcaaaac   Agttaacatt   Tacaattaca   Ctccttcccc   660     Ctaagtacag   Actgcaaagc   Cagacagagc   Tggcctggcc   Gccaccactg   Ccaatgaaaa   720     Cgccttggga   Aaagccaaaa   Gtgctcactg   Ctaaacacca   Ttgtcagcta   Aagggaaaaa   780     Aaaaatccct   Tttaaggaaa   Gtaacttcaa   Taggctcctt   Ttctgccagg   Acctccaatc   840     Cctctgaaca   Taagccgaac   Cacagactgc   Cgcacatgtg   Tctgggtcct   Ggcttttctt   900     Ccctcacccc   Tccgcagagc   Ttcagcacca   Gttgttagcc   Aaaaataaac   Accattcctc   960     Aaccatatat   Gtccaccggc   Ccagagtcgg   Ggaggaggag   Aggaggcagg   Tcagccgtcc   1020     Cccggctgca   Gctgcactca   Catgtggcca   Ctgctcacca   Tgcacataac   Ccagctcaac   1080     Cgggagtgcc   Tgctgcacct   Cttctccttc   Ctagacaagg   Acagcaggaa   Gagccttgcc   1140     Aggaccctg   Cccagctcca   Cgacgtgttt   Gaggaccccg   Cactctggtc   Cctgctgcac   1200     Ttccgttccc   Tcactgaact   Ccagaaggac   Aacttcctcc   Tgggcccggc   Actccgcagc   1260     Ctctccatct   Gctggcactc   Cagccgcgtg   Caggtgtgca   Gcattgagga   Ctggctcaag   1320     Agtgccttcc   Agagaagcat   Ctgcagccgg   Cacgagagcc   Tggtcaatga   Tttcctcctc   1380     Cgggtgtgcg   Acaggtaggc   Caccttgcct   Cctgagcagt   Gctggccccg   Ctagctctgg   1440     Cttccctctt   Ggggggcagg   Gaagagcaaa   Ttacgagacc   Aagatggctc   Caccttcggg   1500     Gcgcctcaaa   Ctaggcccaa   Ggcagacatc   Cagaccgccc   Aaagcagggt   Ccccaggaga   1560     Caataaaatc   Atgagggaaa   Caattgctaa   Tcctcctctt   Agcctcacag   Gtcctgggct   1620     Gcttcatgca   Aacaccaaga   Aggtggccct   Ccgtactggt   Agtcattaag   Tgctgggtgg   1680     Gtccagctgg   Gcctggattt   Tcaaggtcag   Gctctgggaa   Aaggcttcca   Gatgcagcaa   1740     Tcagctcacc   Cctccattag   Gcctagcaag   Cagccctcaa   Ggcctgggaa   Actacggagg   1800     Aaagagaggg   Tggggagcca   Gaggtggaga   Agccagggtg   Ctcaggtcag   Ctgagccaaa   1860     Ccagactcca   Ggagtagatg   Aattactgat   Ttacacagta   Ttcctaagga   Gggtggctta   1920     Gcctaatttt   Tcaaattagc   Aaactgatgc   Tccacgaggt   Ggtatgattt   Gcccagtcta   1980     Gggttgccag   Attttagcaa   2000       <210>   twenty three   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FERD3L     <400>   twenty three   Gtaccacccga   Cccttcaggc   Tttttaaaaa   Cgtaagaatt   Tctactttat   Tatctctatg   60     Aaaaaaaaaa   Tgtaaagaag   Agaggttaga   Ttttatagaa   Gctccaaagt   Ctgccatttg   120     Cgaggagggt   Tcacttccca   Cccacccagc   Ccacggaagc   Tcttaggagc   Agcctgaacg   180     Gccccgactc   Agcctcacgc   Tctctgactt   Ccccgctcgc   Ccctgacccc   Gacttcactt   240     Agggcggtcg   Cgtagatatg   Aactctacag   Cagccactct   Gctcagcgca   Tgtggggatc   300     Ttacaatctc   Gaccccgacc   Tccagaagac   Cagacgttct   Gtcttggggc   Ctccctcccg   360     Gccctttagc   Ctcacccagt   Gcccggtcct   Gacacacccc   Agcactacca   Gacgaggaag   420     Ggcagactct   Ccacaccagg   Ctcagccgct   Ttccttcttc   Tcacagctct   Ccaagagctc   480     Ggtcatgaag   Gagatataga   Cgatggccag   Gcggagggtc   Tcgatccggg   Acagcctttt   540     Ctcgtaagca   Aacgtgggca   Ccttcctccg   Cagctggtca   Aaggcctcgt   Tgaggttgaa   600     Catccgcttc   Ctttcgcgga   Tgttggcggc   Ctggcgctgg   Gcgtaggtga   Tcaccctttt   660     Cctcttgggg   Cggcctaata   Gggagacacc   Tcttccgcgc   Tcctcttcct   Cctcctcttc   720     Tccgtccccc   Tggtccactt   Cgcactcctc   Ttcttctggg   Tccccctctt   Caaaccgcgc   780     Catcctcctg   Ggtcttccct   Ctcggagcgc   Aagggctggg   Tcccccaagg   Agacccggg   840     Tgcgaagtcg   Cagaggagag   Ggcgtctcgg   Ggaggccagg   Gacaggtctg   Cgacgaagtc   900     Cagcaccgta   Gtgtccacgc   Agctctccgg   Ataggccgcc   Atcgcttcgg   Cttggccctg   960     Cctctcatcg   Gttttccgca   Gggaggggcg   Aggttgctgg   Tggggattct   Taacagcctt   1020     Gaatctgatg   Gggcaccatc   Accgaaaggc   Cagggaacat   Taaatattta   Taaccaagct   1080     Gataacagga   Ttagtcgcac   Cgataaggaa   Tgctctgaca   Acgtcccttc   Tctcgaagct   1140     Tatggaagat   Gacaagcttg   Agcacgcatg   Gaagactcaa   Agggacaggg   Ctccagttct   1200     Gagatccttt   Tctctgcgcc   Acccgggaca   Gttccttgtt   Ggcaacaacc   Cccagctctt   1260     Acctgctgtg   Ctttttgtgt   Ctgtcttcac   Ccctgcagcc   Aactaatgtt   Ctccaggctc   1320     Cttatctcgt   Gtagttcttt   Aatttcgtgt   Tggattttca   Aagcgaggat   Gttttccacc   1380     Gcgatggctt   Ctccttgact   Tcagggtagg   Agtcttgaat   Cttgccacca   Tctgccaatg   1440     Gatgtggagc   Aagtgcatgt   Gcttttaatg   Atgtcctgaa   Gaggggccct   Gcctgcctgg   1500     Catcaagggg   Agctgtttgt   Ctggtatccc   Agtgcagcgg   Ctgctgaaag   Gcaagacctt   1560     Caattagctt   Aagtaagcat   Ggcaggggga   Ccgagagtgc   Attccccaga   Gtcgctgttg   1620     Gaaccggctt   Tcttttcttt   Ccagggcatc   Gcaaacagct   Ctcctgccac   Gttacaaacc   1680     Ctgacttcta   Aagtctgttt   Ggatgcaatc   Agcgtaacaa   Ttgagatact   Tgactttcct   1740     Ttccctacct   Ttccctccta   Ctcatataaa   Atagaggatt   Tttatccaag   Aggaaaagtt   1800     Atgatggcaa   Taaaatgaga   Aatttaagct   Caggatattt   Tctatgctcg   Ggctttgctg   1860     Tatacttttc   Agtgtggggg   Acaaagcaaa   Ctctcctcac   Aaacaaaacc   Acttcaagct   1920     Cttttcagaa   Atgcgatttg   Cccttgataa   Gccaaagagt   Caatcagctc   Accctctgct   1980     Gaggagtctt   Cggactttta   2000       <210>   twenty four   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FEZF2     <400>   twenty four   Ggcccccccg   Ccgccgccgc   Cgccaccgcc   Gccgccgcct   Ccgccgccgc   Ccgcccggag   60     Gctgcttttc   Cagagctccg   Agtaactgag   Cagtgtcttt   Gacggcacct   Cgtagcctag   120     Gggctggagg   Gggatcatac   Agggcagcgg   Cgagcagagg   Ttgagcagtt   Tcttgccctg   180     Gctgccgtcc   Gcctctagcg   Ctccaggccg   Gggctcaaag   Ggcgcacggg   Gctccgacgt   240     Cttggccatg   Atgcgctcga   Tggaaaaggc   Cagtgtcttg   Gaagtggccg   Gcgacgctcc   300     Ggcgcgcggg   Caggccgggg   Gcaccatggt   Ctccagggaa   Gccgagcttg   Ccatggcgcg   360     Cggagctgag   Ccgagccagg   Ctgggccagg   Gcgcagcctc   Tctcctctaa   Gtctgcattc   420     Cggaaaaggc   Aggggggaaa   Actgcaattt   Aataagcacc   Tagtcgggcc   Cgggtcaccc   480     Atttgcattc   Aaatgaacag   Gggcaaaaca   Aagtgcaccc   Aagggtacca   Aattaccgcc   540     Cattaacccg   Gcgcgcaaag   Gaacccacca   Gcccctgccc   Tgggactttg   Aaagggggaa   600     Gaagggggag   Ggtttacaaa   Agaaaagggg   Gggggcggtg   Gagaaagagt   Ctcaaattaa   660     Cccccctgag   Cccttccctg   Gaccggggcc   Tctgccacgc   Gtgctgggag   Ctggacagtg   720     Aaggggcaaa   Gttaaagagg   Accggagagc   Cacctcgcat   Ttcctcttt   Cccccaccac   780     Caaggagatg   Cgttccgagc   Catgcagcgt   Gtctcttctg   Tcacattttg   Atggcaaaca   840     Tcttcccctc   Cgcgtgagat   Cactgtcttt   Tacattcagc   Tgacatcaca   Tgaagtcact   900     Tgaagtggaa   Tgacatgggc   Ggcggcgcgg   Ctcccgtagc   Ggcccctgtg   Ttcccccgcg   960     Cctgccggcc   Gccgccacca   Ccgcccctca   Aactttaaaa   Ggaggcaact   Ggcgcccgcg   1020     Ctcctctcgg   Gaaagtgcga   Gcggtttgcg   Aatagggaaa   Gagggaagag   Acgggagggg   1080     Gagggggagg   Aatcgtgatg   Gttttgccgg   Tggaaggaaa   Gggggggggg   Gacccaaacc   1140     Caaacctagg   Cagagttccg   Tgcgtgattc   Acaactttgg   Aggcctgcag   Gtttggggga   1200     Cgcggggagg   Gcggagggtc   Ccggacgcgg   Cgcccccaaa   Gggcccctgg   Gtatcagtct   1260     Agtagccgaa   Gtatccctta   Gccctccgca   Gccgagctgg   Gcatcgtgct   Aataaactgc   1320     Catttaccca   Cggaaccggc   Gccagccccg   Aacacgcgca   Aatgataatt   Acctcattag   1380     Gatgtggcgc   Atggacgcgg   Gcgccgcgtt   Tggagggggg   Aacttgttaa   Tggggaaata   1440     Ttaatttatg   Caaaagcaat   Gagctcgcct   Tggctggcgt   Cggaggtcgg   Gagaaagctc   1500     Ccactgacta   Aggaggcccc   Cgaagcgtca   Cggagagcaa   Ggccgctcgc   Cggcatctcg   1560     Ggggcctcgg   Cgccgcgcag   Gtgcgcctcc   Agctttatgg   Ccagctctgg   Gtctgaggct   1620     Gggggagact   Aaaccgagag   Ctggaagact   Ttcggagatc   Ctaatagatc   Gaaattgttg   1680     Atttatgatc   Gggtttctga   Ggcaaagccg   Agttctgctt   Ctggtttagg   Gctgcgtgcg   1740     Gggaggattc   Ggagggcagc   Tctcccagct   Gatgggtact   Tactgtttgt   Ataattgaga   1800     Aggtcccatc   Tccacctgtt   Taaggagcag   Attgaaacag   Cagaacctcc   Ccctggatcc   1860     Tattaaaacg   Tttttcctcc   Taaggccatt   Cagtcgaacc   Aattttccga   Agtgattcat   1920     Agagctgaat   Tctgccaagg   Cagctctttc   Acttttagcc   Actaaagcac   Cgcgtggaac   1980     Cgggttttgt   Gtttttctaa   2000       <210>   25   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FIGLA     <400>   25   Tcttctaccc   Ctcacccttc   Tctctcctgg   Attcgcctct   Gctgcaacca   Aacccgtaga   60     Ctgcaaacgc   Taggaaggag   Accatgtctc   Ccaagtttgg   Ggctgagttt   Cgttagatag   120     Taaaatctac   Cagcaggtgc   Cgctccaacc   Acggcccaca   Ggacccttcc   Cgtttgcgag   180     Ttgctgcggc   Tcgactggga   Aacactcact   Tttacttgac   Agaggtgagt   Gggagtcttg   240     Ggtgcacact   Gggacgtcgt   Gtttcgttac   Tttaaaaaag   Aaaagcact   Tccgtcaggc   300     Ccccctttct   Cctcaccctc   Gtgtgtgctt   Cgaggccgag   Atgcagagag   Caagaaaaag   360     Gagcgaaggg   Gatccctgcg   Cgtcccaagc   Acccaccagc   Gcctacggtg   Tgagatgaag   420     Gcgcaccccc   Tgggcgcgaa   Gcttttaaag   Cacctgccca   Gggagacatt   Tttgaagttg   480     Tcagggcccc   Tcctctgtcc   Cctcccagac   Ccgggtcctg   Cacaaatcct   Ggagggttag   540     Cgggcgaggc   Ggccaccgca   Gcggccgcca   Acgagcagct   Gcacggaggt   Gcagaagaag   600     Gaggccactg   Ccattctcct   Gacaagctgg   Gggcgtggga   Ggcctcggga   Gctcgaagtc   660     Gcctcgagcg   Ggggtgggcg   Gtgagcggac   Cccggggtgt   Tgaccaggtg   Tttggtggta   720     Gagcagggaa   Ggggggaacg   Gacgtcgacc   Ctagggatcc   Ctcacccgct   Cacgctcctt   780     Ggcgttggcc   Acacgccgcc   Gctccagcac   Caactggagg   Ttttcagtgg   Acgagtagcc   840     Gcccgagggc   Agccgcttga   Gccggcagac   Agcggccagc   Tggggcagcg   Gcccgaactg   900     Ctcccgcaac   Acgtcctcca   Gcacctcggc   Ttgcggggtg   Cccaggagcg   Cgggcggcgc   960     Ggcgcgggga   Tctaggacgc   Cgggcgcggg   Gtccatggca   Gggccgaggc   Cgctgaggcc   1020     Gggctttcac   Ctgcgcaccc   Ggggccgcac   Gaggcccggg   Cgggggcggg   Gcgggggcgg   1080     Gagctggacc   Acctgcaacc   Attccccggc   Tgcgtattcc   Aatcccggcc   Tcctctctgg   1140     Aggctgcgtc   Caggcatcgc   Gttgaataag   Ccgcacaggt   Gtgactcggg   Agcgctggag   1200     Cgcagccccg   Gctgcacacc   Tggaaccgcc   Gggagcgtgg   Tagtggtgtt   Tttctcaatc   1260     Cacatgccac   Ggttccagtc   Ccccaaattc   Ccatttaatc   Aatctgtctt   Ggggcctgag   1320     Cttctggcta   Tgtgtataca   Gaaaaatgtg   Atggatatcc   Acaaaacttt   Tttaagaatt   1380     Cgttttgaaa   Taaaagttgc   Ggggaaaatg   Gcaagaagag   Tttctaagag   Ctcctgtacc   1440     Cccttcgcca   Cgctctctac   Ttgctaagtt   Ttcacgtttg   Ctccgttgcc   Ctctttctcg   1500     Ctgtgaatat   Tctcattttc   Attattcttt   Ttccattcta   Tttgaactat   Tttctttttt   1560     Cgcgagtggg   Gggatacatc   Gctttattca   Ttttccccct   Tttccacaca   Gacctttatt   1620     Gtcaacacag   Ccaaacacag   Ttgttacttc   Agaaaatgtg   Ctggaaaata   Gcgatcccaa   1680     Acttgtttaa   Tagtagagta   Caatttagta   Ctctagaaat   Aattaactac   Atcttctgtt   1740     Ttgagtagat   Tactcatgag   Agtttgtttc   Tctggaggtt   Atcaatataa   Ctggaacatt   1800     Ctgatcttgc   Acctgaaaat   Cagacatgtt   Tctggaagcc   Ctctgtaaaa   Tcattccttc   1860     Caagcataga   Aatacatttt   Tttttctttg   Gtctgagaaa   Atattttttc   Tacgcttttg   1920     Tttcaggttc   Aggggtatat   Gtgcaggttt   Gttaagtggg   Taaattgtgt   Gttgctgagg   1980     Tttggtgtac   Gaatgatccc   2000       <210>   26   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FLJ32255     <400>   26   Tcgttagctc   Tttcaccagc   Ggcgcggagc   Gggcggtttt   Gctgtcacgg   Cacatgtggc   60     Acggagtttc   Tcggtggccg   Aaaccctctt   Ttttctcaga   Gtccagtttc   Ttggtgacag   120     Cgctgttggt   Tgcgccataa   Ggaatgttgt   Ccttgacaac   Ccgccggccg   Cagtcattcg   180     Caagctccag   Gcaccgacat   Ttcgcagaac   Tgaggtctct   Cggtctcagc   Acagctcgtt   240     Gctcgatgcc   Tccattttct   Cggggcgaca   Gcactcaggt   Cgccgatctg   Agggattcgg   300     Agcttcccca   Gctggggtga   Gcctggcgtt   Cccgggcggc   Ggcggcggcg   Ctgggctagg   360     Ggagcccgcc   Gctcctccaa   Gccggtgaca   Ggggagctgc   Ccgggcgccg   Tctcttccca   420     Gcgccgccgc   Agaacccgca   Gaacagctcg   Acctccagaa   Ccctgtgctg   Tggcggcggg   480     Gctggcgtgt   Ctgtcgcagg   Accccgcaga   Ttcgtctgtc   Gttggcttgt   Tggtcctaac   540     Aagtttcgat   Ttcagggtgc   Ctgcgtttct   Ttttcttttc   Tcttcttttc   Cttttgtttt   600     Gttttgagac   Agaggtcgc   Cgtgtcgccc   Agcctggagt   Gcagtggcgc   Gatcttggct   660     Cactgcaacc   Tccgcacccc   Aggttcaagg   Gattctactg   Cctcagcctc   Ctgagtagct   720     Gggattacag   Gcgctcgcca   Ccacgcccgg   Ataatttttg   Tatttttact   Agaggcggtg   780     Tttcatcata   Ttgaccaggc   Tggtctcgaa   Ctcctaacct   Caataatctg   Cccgcctcgg   840     Cctcccaaac   Tgccaggatt   Acagcatgag   Ccgctgcgcc   Cagccggtga   Ctacgatttc   900     Tatcccctgg   Ttcaagtcgg   Ggaatagcca   Aaatgtgatt   Tctcaaccca   Agcaagtacc   960     Cacttaggac   Aaacaccagc   Ctagccctgg   Cggcgatttc   Taggtcgtag   Gaagtcgatg   1020     Tttcgccaca   Gaaaggctga   Gtgaccctgt   Gactcatttc   Ccagcaactc   Cgggtttcct   1080     Gtagcctaat   Cataacaaac   Gcagagttag   Ccctgcctca   Agtttctttt   Ttctttttct   1140     Tttttttttt   Tttttttttt   Ttttttttga   Gacagagttt   Ctttcgtcca   Ggctagaatg   1200     Cagtggcgcc   Atctcggcga   Tctcggctca   Ctgcaacctc   Cacctcccgg   Gttcaagtga   1260     Ttctcctgcc   Tcagcctccc   Aaatagctgg   Gattataggc   Gcccgccacc   Acacccggct   1320     Aatttttgta   Tttttagtag   Agacggggtt   Ttgccacatt   Agccagactg   Gtctcaaact   1380     Cccgacctca   Gatgatccac   Ccgccttggc   Ctcccaaagc   Ctcaagtttc   Taagtcgtgg   1440     Caagttccgg   Cttcctacta   Gtaccggttg   Ctttagctgc   Gcaggagatg   Ttcaactcct   1500     Gtagaaatct   Gtgtaccagc   Gaatgcgatt   Catttaggtt   Tagcgatgac   Cagtttagca   1560     Gtgcctggga   Gctcttacac   Caaggctagc   Tgcgcaacat   Caagtcccgc   Cttagctatg   1620     Ttggtgtttt   Ttaaactccc   Atggaagtca   Ggaaatgccg   Gcaaaagcga   Tttctggttt   1680     Acgaagctcg   Gtttgacgat   Agcaatttcc   Gccgaacgcg   Actttttcct   Cttgtggacc   1740     Aagtcgggat   Atatcagcta   Ctacgatttt   Ttagtcgtaa   Acaggtttaa   Ccatgactgg   1800     Gttttgttgg   Tttcttgttg   Ttgttgttgt   Ttgtttttgt   Ttttgtccta   Agaaatgtag   1860     Acttaggtgt   Aacatgtacc   Ggtttagatc   Taacagggat   Atcctaatca   Cagaattgct   1920     Tcttttggca   Atacttgtaa   Tttctgcttt   Gtagggttgg   Ttctctctaa   Tttttgctta   1980     Tttttaaatg   Ctctttttgt   2000       <210>   27   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   FOXB2     <400>   27   Tcggtcatgt   Gatagtctcg   Aagcgctagc   Tgcgggggtc   Tcggcgtctc   Ggggaccatt   60     Acaaaacgca   Gccaggagag   Cgcgtcgctg   Ccactgccgt   Cgcctctcct   Cctcaagaca   120     Agcccgggag   Aaaggcggca   Gctgcggcgc   Ggacggctga   Gcctccccgg   Ccaggactca   180     Cccagcattc   Gcagacgccc   Tctccagccc   Gccgctcgct   Cccagagtcc   Tgcgccccac   240     Actcctcagc   Agaacctgcg   Ggcgctgccg   Cttcagaaac   Caccaaagtt   Ttttctcctc   300     Agcgacagcc   Tagggctgcg   Cgtctcttct   Aaccccggcg   Acgctgcgag   Cctcggagaa   360     Aagagaggcg   Ccctagaagc   Caatcttctc   Tctccttacc   Ctgatttttc   Actccaggaa   420     Aaggagaact   Ccaggccggt   Ctggctaagt   Gcctggccag   Gggcctgcgt   Ccagggcact   480     Ggaagtcctg   Ctgtcactgg   Cctccaggac   Agcaggcgca   Aactcagatt   Taaagggcca   540     Gagtctctac   Tgcccagacc   Ttcctcccag   Ccatcttggt   Ctgggtttcc   Ctcggaccta   600     Gaaaaagcaa   Agaggccggg   Aggaaacacg   Gccccttgcc   Actctcctct   Gcagccagct   660     Ccaggactca   Gtctttggcc   Acccggggga   Agacgcagag   Aaggcggcgg   Taaacctggt   720     Gcactccgcc   Cgcgactgtg   Cgcgccagtc   Ggcaaccgtc   Ggggccagaa   Gttgccagct   780     Tccgagagct   Gagtaggccc   Gaaaggccaa   Ggtcggagac   Accaggcaat   Tcggagaagg   840     Caggagagag   Aagcagagag   Ggcctggagg   Gcgagagggc   Aaagtggcgg   Gactggaggg   900     Gccgagtggg   Aattagtggg   Ggcagccagg   Ccccaggaac   Ggagtgcgga   Gagattctgt   960     Ggtccagtgc   Gggccggagg   Gcggtggagg   Agccgggggc   Gatgccgcgg   Ccggggaaga   1020     Gctcgtacag   Cgaccaaaaa   Ccgccctact   Cttacatctc   Gctgaccgcc   Atggcaatcc   1080     Agcactcggc   Cgagaagatg   Ctgccgctga   Gcgacatcta   Caagttcatc   Atggagcgct   1140     Tcccctacta   Ccgcgagcac   Acacagcgct   Ggcagaacag   Cctgcgccac   Aacctctcct   1200     Tcaacgactg   Cttcatcaag   Attccgcgga   Ggcccgacca   Gcctggcaag   Ggtagcttct   1260     Gggcgctgca   Ccccgactgc   Ggggacatgt   Tcgagaacgg   Cagcttcctg   Cggcgtcgca   1320     Agcgcttcaa   Ggtgctgcgc   Gccgaccata   Ctcacttgca   Cgcgggaagc   Accaagagcg   1380     Cgccgggcgc   Cggtccggga   Gggcaccttc   Acccccatca   Ccaccacccac   Ccccaccacc   1440     Accatcatca   Ccacgctgcc   Gcacaccacc   Accatcacca   Ccaccccacc   Cagccgccgc   1500     Cgccgccgcc   Cccgccgccg   Ccgcacatgg   Tacactattt   Ccatcagcaa   Ccgcctactg   1560     Ctccgcagcc   Gcctccgcac   Ctcccgtcac   Agcccccgca   Gcaaccgccc   Cagcagtcgc   1620     Agcctcagca   Gccgtctcac   Cccggcaaga   Tgcaggaggc   Ggcggccgtg   Gcggcggcgg   1680     Cggcggcggc   Cgcggcagcc   Gcggtgggca   Gcgtgggacg   Cctgtctcag   Ttcccaccct   1740     Acgggctggg   Ctcggccgcc   Gccgctgccg   Ccgcggccgc   Ggcgtccacg   Tcaggcttca   1800     Agcacccctt   Tgccattgag   Aacattattg   Gccgggacta   Caagggcgtg   Ctgcaggctg   1860     Gagggctgcc   Cttggcgtcc   Gtcatgcacc   Acctgggcta   Ccccgtgccc   Ggccagcttg   1920     Gcaacgtcgt   Cagctccgtg   Tggccgcacg   Ttggcgtcat   Ggattcggtg   Gccgccgccg   1980     Cggccgccgc   Agccgcagcc   2000       <210>   28   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   GALNTL6     <400>   28   Ggcatcatat   Ccaggttgta   Acaaagaggt   Gaccatggcg   Tttatttttg   Gctccagaca   60     Ggcggattca   Gcctgcattg   Catgcatgca   Tgtctgtcac   Ctcatctaag   Tccccattcc   120     Ttccggagtt   Gtgagctcca   Gatccaagag   Tgcccagtgc   Acggtgctgg   Gcacgctgtc   180     Cctgtgcgag   Gctgccacag   Gttcctgagt   Gtgcggtcag   Gggcgttggt   Gcattgatac   240     Gttaggcgga   Gggaggagta   Ccatctgcca   Gagtcttatc   Tcgagtccca   Cgttttctgg   300     Ccatcgcgga   Ggagtgtgcg   Aggacapgta   Gccctcgcag   Tgacaaggcg   Cgcggagtgc   360     Ggtcgtgcaa   Ggcgggggag   Gaggggggtg   Gccctgccga   Atcttaaccg   Gggccccggg   420     Tgtttgcaga   Cccaaataaa   Gccgccttgg   Gtctccacgg   Tgtcctccag   Aagctgctgc   480     Ctgagaactc   Tgagcctcag   Ctctgtcttg   Cttcgggatc   Ctcttcctcc   Tccttcccca   540     Ccccctacct   Ggcctgaacg   Gcggaacgcg   Cggctcgggg   Gatcccctct   Ccctgggacc   600     Ggccctgtcc   Cgggtcgcct   Ccaccctcccg   Cagccgccgc   Gccccggctc   Gccgcgctcc   660     Cgccggcacc   Atggaggaat   Tcctgggaca   Accgcctgca   Gccggcgact   Tttccccagg   720     Aatctctggc   Ctggcgccct   Ttgggtgaga   Tgacggggtg   Ctggcatccc   Tgtcggtccc   780     Agattacccg   Gaaaagccct   Ggcaggtaaa   Gagaggaccc   Gcgcaggctg   Ggagctccca   840     Ctcctcctcc   Agcgtcacgc   Tcgccctccg   Ccgctgcctc   Gcgtccgggt   Ctgtttatat   900     Agcgtctgga   Ggccgggagg   Cattgcccac   Ccccgccagg   Cggcccgccc   Tcccctcctg   960     Ggctccgggc   Tgccgcacgt   Ggcagacacc   Agcgacgtct   Ccgcggaagg   Caggcgccgg   1020     Ggagtggggc   Gcgggcgacc   Gtgtgcagcc   Gcggcgcatc   Tccgccttcc   Gctcctcctc   1080     Gcagcgccct   Cgtccgcttc   Caagcccagc   Acagacttcg   Gtttctccgc   Ctccatcccc   1140     Tttacgagaa   Gaggagatca   Aaaaatattg   Ccctttaggt   Gctcgtgatg   Gtcctgtggg   1200     Ttcgttcagt   Tgccagaaaa   Gaatggtaac   Atgaacagcg   Gagcgtgaga   Gcgtcaccgg   1260     Gggaagggac   Gagattgatg   Ggcagagcgc   Tcacttctca   Gaggatcgca   Ttccgaggac   1320     Cgcgcgagga   Agggacgtcg   Cggcgccacc   Acttcctggc   Tggactccgc   Tgacatctgt   1380     Agcctccttt   Ccaccaggtt   Cccggggctc   Ccagccgctg   Cctgcagagg   Agcgtgtaga   1440     Cagcgcgcga   Gggtccggca   Cttcgtggac   Ctccatccga   Accggagttc   Tgcccggatc   1500     Ccgagtccct   Gtagcccggt   Ggagcccgcc   Ggcaagctgg   Ctccggaggg   Agttgaactt   1560     Gagttcaggt   Gggttatccc   Aaggggagca   Caggaaaaga   Tgttcaggga   Agacgaagaa   1620     Ggtgacgctg   Ttccaatgtc   Aaaagcggac   Acttttcttc   Ctgacacttg   Aaggggtga   1680     Gccagttcct   Ctcagttctg   Tctcctaacc   Cgctccaccc   Cgacccagcc   Ctcccacact   1740     Aaggaggtgg   Ggggcgaaca   Acaacaacag   Caacaaaaac   Tcccagttac   Ctaagtatct   1800     Agcaggctgt   Tgactttttt   Ataacttacc   Tttagtcaat   Gaaacgacca   Tatttactct   1860     Attgctttat   Attataggag   Gtcaatgggc   Tatagtattt   Ctttagtcaa   Gtcatttatt   1920     Tctaagccaa   Tagataatgc   Cttcgtcata   Gttttctggg   Gggaaagtaa   Ctgtgcgttt   1980     Gttctgcaga   Tggccaactc   2000       <210>   29   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   GIGYF1     <400>   29   Tgggcgtgtt   Tgagaggccg   Ggggtgggga   Ggaggggacc   Tggcgttcac   Tgtccaaaca   60     Cctgtggggg   Aacaggggcc   Atgaagaaca   Gcacacgaag   Gagaacttta   Aagcgcaggg   120     Aggacapcat   Gggggacatc   Ctagtgggca   Caacaatggg   Cccgggacta   Gctggtgggt   180     Cacctggggt   Ctaaaaggac   Tcacctgagc   Cagccacgtg   Gccactcaca   Ccatgagtta   240     Cccagagatg   Agtccagacg   Gtgaaagacc   Tgggggaggc   Gaggagatgg   Gaagctcgag   300     Tcctttcggc   Ctcagcaggg   Caaccaccct   Tggcccgggg   Ctcacctggc   Agcctggccc   360     Gggaagaagg   Agggcagggg   Ctggtgctgg   Agtgaacgag   Ggtacccaag   Ccactgggaa   420     Ttggtctgac   Ctcagtagag   Cctgggaggg   Accttcacat   Ctgggaaaga   Cccttaagga   480     Gagcaggggg   Gaggagggag   Ggttcaggac   Atggctctgc   Cggcagccct   Gccctgcccc   540     Gcatgacagg   Agaggtccat   Tcgccggatg   Gtgtctctgg   Gcatcagcac   Cctcgccacc   600     Ctctctggga   Ggctgagaca   Ggaggtgtag   Tgaagaactc   Ggggagggag   Gcagccgagg   660     Ccaggatgga   Cgttcagggc   Aaagataaaa   Caaaaacaag   Caagcaaaca   Aaaacccact   720     Agagccacaa   Atagcttaca   Gagaaaaggt   Cagttacgga   Gaaaaggatt   Agaaataaat   780     Ctaggagcaa   Aattctttcc   Ctcatgaaaa   Aaatcagttg   Gctgctcaga   Agctcaaatc   840     Caggggcttg   Gtctggggag   Aaacccagtg   Aaaaggagca   Ggaggtgact   Ctagggccac   900     Agacgggtac   Acgacaagga   Ctccaggcag   Gcaagcctga   Gccaaggcac   Ctcgggctgg   960     Tttcccccac   Aggaatcaca   Cccagaccac   Cgcccccaat   Caataatgga   Ggcttaaaca   1020     Accaagccac   Caagggaacg   Agtagctcag   Gataccagct   Gggaagcagc   Ctctggcacc   1080     Atcaggtgga   Aataaggtca   Gggcaatgga   Ggctgatggg   Ggcgcggcgg   Cagcctgttc   1140     Ctctaaggga   Ggatggaggg   Gactttcagg   Aggaggcgca   Tccctggggc   Cccaggcaga   1200     Ggactcaagc   Gggtgggcgg   Ggtccaggtg   Ctgcggtgtt   Gtcactggct   Gggagggagg   1260     Ctggcccggc   Ttggtgctgc   Agctcccatc   Aactccagga   Cgccacagtc   Tgggaaagaa   1320     Gaggaagcgg   Gttcaaccag   Ggtgctgagg   Aggaaaggcc   Atcagcccca   Gctgagccag   1380     Cagcccatga   Caagccgagg   Cctgctcaga   Gtccaggcac   Tccaggggga   Aacaccgggc   1440     Tcagaggcaa   Cccaaggcca   Ggctggcctc   Ccctgggacc   Tctccttcct   Ctgcctcggc   1500     Tggatgctcc   Agtggtggtg   Tgttccatga   Catgaaaagc   Caccagcctg   Tcactgactg   1560     Caggtggcca   Ctagagacaa   Tctggggact   Ggatgagcct   Tgaggacatc   Acgctaagag   1620     Aaacacacca   Gccaaaaaag   Gagagctacc   Ccttacttct   Ctttcatgag   Gtctctagag   1680     Cagtcactca   Ttgagggagg   Aaggtagaag   Ggcagccacc   Aggggctgag   Gggacaggga   1740     Gctgttgctg   Aagggtccag   Agcctcaact   Gaggagggga   Tcctggggcc   Gctggtggtc   1800     Atggccgcac   Accaatgtga   Gtgtacttag   Taacacagaa   Tggcacaatt   Agagacagtt   1860     Aaagtctcca   Aattttgttg   Tatattttac   Cacaataatc   Atttttttaa   Aaaagcttta   1920     Gggaacaaaa   Ggtatctgga   Gataaccacc   Gcatacctaa   Gttttcccca   Ctccaagaaa   1980     Aacaccccac   Attccttcaa   2000       <210>   30   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   GRIA4     <400>   30   Cgcagttctt   Attcctatcc   Ctgcttcatg   Cctttccaag   Agaatgttag   Aggcctcttt   60     Caattttcat   Ttctcagtct   Tttccccatc   Ccgttcagta   Ccctaaactt   Cgtcagttat   120     Ttaaaataac   Cttttacccc   Ctcctcccct   Tcccaggatg   Tttcaacttc   Tctggctctc   180     Ttccccatcc   Ttccctcctc   Caattctttc   Atcctggtcc   Tggcctctta   Aacccgccag   240     Gggctgccct   Ttgcctgtct   Tttctcctcc   Catccctctc   Tgaacccttt   Cacctcatcc   300     Attcccttgt   Caggctctcc   Agattcccgg   Gctgtttgct   Ggtgagaaat   Ctttgctgca   360     Gcgaggaccg   Gagtcccccg   Cgcgcagccc   Agtggcagaa   Gagggctagg   Ctgagaggga   420     Agccaggact   Gtaggagagg   Gaggcagccc   Gtcctcctca   Cgaacctgca   Agtaggcggc   480     Agggggctgg   Gggcatgggg   Aggtactaac   Cccccggagc   Ccccgattgg   Ggcttgcaga   540     Cctggcccgt   Gggcggattt   Tctgcctagc   Gcagccgaga   Agcagaggtg   Ccaggaaaac   600     Caagagaggg   Gcgctggggg   Tgcccatccc   Cagagtcggt   Ccctctgcga   Accgaggaag   660     Aaaagaggag   Ggagtcagcg   Agtggtcaga   Agggaaaacc   Tgacaccaga   Ctggctccgg   720     Agcgtccggg   Agactggggc   Gctccggtga   Gcacccaggg   Ggtgaagcca   Gccgagcggt   780     Gggcgagggg   Cgtgcggagg   Gagtgcgcgc   Tcgaggaggg   Gacgccagga   Gggcagcgat   840     Gctccgggct   Ggtgcaggct   Tgctggggga   Tgtcggctga   Tgcgagctgg   Agagcgcgtg   900     Tggcggccgc   Ggcgccagtg   Tttgtgtgta   Tgtgagaaag   Caaggggcga   Gcgcgagtgc   960     Gagtgaggca   Aagatagagc   Gcatgtctca   Tccctgcgag   Cagccactag   Acgctccacc   1020     Accatctttt   Gcatgtgcaa   Catttgcagc   Cggacagaaa   Acctctccca   Gggctatgga   1080     Gactgcggga   Aaaatctggc   Ggctcgcgat   Ggattgctaa   Ggagaactag   Tcataatctt   1140     Aaaccaccga   Aacctctttc   Cttttttttc   Tttcttttct   Ttcttttctt   Tttttttttt   1200     Tttttttggt   Tgattttaat   Tttagcgcca   Tcgtcttcaa   Tgcttctctg   Aacagccttt   1260     Aggaagagtg   Cgagagaaag   Agagagagcg   Cgcgccaggg   Agaggagaaa   Agaagatgag   1320     Gattatttcc   Agacagattg   Tcttgttatt   Ttctggattt   Tggggactcg   Ccatgggagc   1380     Ctttccgagc   Agcgtgcaaa   Taggtaaggt   Gtgctccgat   Ggggtgtgca   Tgtggctggt   1440     Tgtagcagat   Atccgaaagt   Gagttaaatg   Agttgctgat   Aagcaattca   Gggaaacctt   1500     Cagcagttcc   Cttcccctct   Gtttccctcc   Tcttcctttc   Tctcctttgc   Aaaaagactt   1560     Cctctttagt   Gcaggttccg   Ttggaataca   Cccagggcag   Cccacccatg   Cgttctcagc   1620     Ccatagccct   Atttccacct   Ttcctatag   Tcgcttaagt   Aggattgaaa   Taagttgggg   1680     Gaaagtcttc   Ggggaatttg   Gttgtatttt   Atatgatatt   Tatttccatc   Cctttctcta   1740     Aagcataaag   Tgatgtcgag   Tttgtttaaa   Aaagaaaaaa   Aaaatccact   Tcttcccatt   1800     Ctggacgccg   Cagctttctt   Gctattacag   Aaagacactg   Tttgaggaaa   Aagacatttc   1860     Cacccgcacg   Ccctgccgtt   Tcttgctacc   Agttagcaga   Ttccaaagtt   Agatcccttt   1920     Cctggaagct   Tctccccttt   Tattttgttt   Tcttcttgaa   Gcttttgccc   Tttattctct   1980     Acctcgactc   Tgtttccagg   2000       <210>   31   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   GSX1     <400>   31   Catctcggct   Ttcattcccc   Attccctgtc   Tctgttcgta   Acgctcagag   Actgtttttc   60     Ctcttttaca   Tccacggccc   Tgtcatttga   Aggaaagggc   Tggttggcca   Gcatctaccg   120     Aacaaagact   Gggcgtcgta   Ggcagcacca   Aaattaagac   Tatttgagaa   Acttagagaa   180     Aaccgaggga   Cagcgatggg   Tctagggctg   Gataaggaat   Aatgagccct   Tctcctccct   240     Ccccacapac   Gcctccttca   Cgcgggaacc   Cggtcctcct   Tcttccgacg   Cagagagaga   300     Agcgattcca   Caggtggaaa   Atctgagacc   Ggctggaggg   Aggttcgggg   Gtgcacggca   360     Ctgagctgac   Agggctgact   Ggagacagca   Tacttttggg   Gtgtaagggc   Gataatagaa   420     Gaagagggac   Caggaccaag   Tggacagagg   Atatgagggt   Gtgcgcccat   Ggggatctgt   480     Agaagagagg   Ccgcgggggt   Gcaaaatcag   Taaggtgaac   Gggctgatgg   Ccaatgcaaa   540     Gccaaagggg   Agtaagaaat   Aaagagaaag   Gaaagaatat   Taaatcgcgg   Gagaatgaga   600     Aaataaaccc   Gcaaaaggga   Gaggaggggg   Cgagggcgcc   Tgttacggcg   Tgggtggggt   660     Tgacaagaat   Agagtacatt   Atgcagttca   Tttagttaac   Aagtgaaata   Atgaggaagc   720     Gtgcagagtg   Aatgccaaga   Gaaaaggcac   Aaaaacccta   Ttgagaggcc   Ccggccgctc   780     Ctggcgtagt   Ccatcacatg   Gcaatagtcc   Tatttaagcc   Gcgccgccgg   Cgcctttcag   840     Caccactagc   Gctggccagc   Accccgcgct   Ctttgggcgg   Tgcccacggc   Agcagaggct   900     Actgtttcag   Cctaggtctc   Agccgcgcgt   Tcagcctcct   Gggcagaggc   Agctgcggga   960     Taccgcggcc   Agggaaagcg   Cgtggagagc   Cgaaaggtgc   Ggtgggcgca   Gagggcgggc   1020     Tggctgcggg   Gcgaccgcgc   Gccggggcca   Tgccgcgctc   Cttcctggtg   Gactcgctag   1080     Tgctgcgcga   Ggcgggcgag   Aagaaggcgc   Ccgagggcag   Cccgccgccg   Ctcttcccct   1140     Acgctgtgcc   Cccgccgcac   Gcgctgcacg   Gtctctcgcc   Tggcgcctgc   Cacgcgcgca   1200     Aggctgggct   Gctgtgcgtg   Tgcccgctct   Gcgtcaccgc   Ctcgcagctg   Catgggcccc   1260     Ccgggccgcc   Cgcgctgcct   Ctactcaagg   Cttccttccc   Acccttcggc   Tcgcagtact   1320     Gccacgcgcc   Cctgggccgc   Cagcactctg   Ctgtgtcgcc   Cggggtcgct   Cacggcccgg   1380     Ccgccgctgc   Tgctgccgcc   Gcgctctacc   Agacctccta   Cccgctgcct   Gaccccaggc   1440     Agttccactg   Catctctgtg   Ggtaagcggg   Gccgccgcgc   Agagggaccg   Ggcagaggtg   1500     Atccgaagca   Ggatggagag   Cgagagatgg   Aggaagaggg   Accctgggct   Ttctgggggc   1560     Ggtgagggtc   Atgtcgggga   Ctaagggggg   Cgcttggggt   Ggagtgagga   Tagagggccg   1620     Ggacacaacg   Ccaggaggcg   Gatgagggca   Gacgtccagg   Tcctggagtg   Tgggccgggg   1680     Taagtgaggg   Ctgggatcca   Aggctctcca   Tgaaggggaa   Ggggttccag   Ggctgcatga   1740     Ctccgggaga   Atcaggatct   Cggagctgga   Caaggagcgc   Tcactgtagc   Tctgctgtgg   1800     Attgtgttgg   Ggcgaagaga   Tgggtaagag   Gtcaaagtcg   Taggattctg   Gcgaccgcct   1860     Accaagggat   Tgggtccaca   Gcacagaggt   Ctgatcgctt   Ccttctctgc   Tctgccacct   1920     Ccagacagca   Gctctaacca   Gctgcccagc   Agcaagagga   Tgcgcacggc   Tttcaccagc   1980     Acgcagctgc   Tagagctgga   2000       <210>   32   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   HORMAD2     <400>   32   Ggaaagctct   Ggccttctgg   Ccttatgtct   Tttttctttc   Ttttcttttt   Ttttattttt   60     Gagacagggt   Ctccctctgt   Tgcccaggct   Ggagtgcaat   Ggtacgatct   Tggctcactg   120     Caacctcaaa   Ctccccggt   Caagcgatcc   Tcctacctca   Gcctcccgag   Cagctgggac   180     Tacaggcgca   Cgtcaggtgg   Cccagctaat   Ttttgtactt   Tttaaaattt   Ttttgagacg   240     Gagtctcgct   Ctgtcgccca   Ggctggagtg   Caatggcgga   Atctcggctc   Actgcaacct   300     Cagcctcctg   Ggctcaagcg   Attctcgtgc   Ctcagcttcc   Caagtagctg   Ggactacagg   360     Cgcgcgccac   Cacgcccagc   Taatttttgt   Attttttgta   Gagacgggtt   Ttcaacatgt   420     Tggccaggct   Ggtctcgaat   Tcctgacctc   Aagtgacgcg   Cccgcctcag   Cctcccagag   480     Tgctgggatc   Ccaggtggag   Ccaccgcgcc   Gcacttctcg   Ggccttcttc   Taactcgggt   540     Ccctgggccc   Cccaggctct   Cgcttccctc   Ccctacgccg   Ccccgcgccc   Gcctcagacc   600     Tctctgggac   Ccgccggcct   Ggcgtcctgg   Cccgcccgag   Ccccaccgtc   Cctcgggtcc   660     Taacctcggc   Ggggcaggca   Cctcctcagg   Aagccccgga   Gcaggctgtc   Gttgtatagg   720     Tggcccaggc   Tggcggcccc   Tgaccgaagg   Tcgcgtcggg   Tcagtgtgca   Gcccgtggct   780     Gagaggcggc   Tgctgagggg   Ccgggcgggc   Taggggccgg   Ctagccgccg   Ttcgcccctg   840     Ctttgcatat   Tcatgaagtc   Tagcgaggcc   Ggtcgcccag   Gctagccgtg   Gacgggtcat   900     Gaattattca   Tgaggaaacc   Tctggtcccg   Cccagaaagg   Cctcgttgac   Tattcatgag   960     Ccgaggagcg   Ggtttgggcc   Ggaaaaggcc   Gttgaccccc   Ggtgggaggg   Aagcgtcgac   1020     Gagctgaggt   Gagggctgtt   Gagacgcgag   Gtctcggccc   Agagagggca   Ctcgggcgtt   1080     Gttagttctg   Tctttatgtc   Aaaaaacaat   Ttttttttct   Tttcttatta   Cttaaggctt   1140     Taagttggat   Ttgaaagtat   Catatttcgt   Gaggggctaa   Agtactgtga   Agagaatcgg   1200     Gagggcaggg   Ggctgaggag   Gaaggcaaaa   Gggaggcgat   Ttcccccaga   Actggacaga   1260     Gagcacccag   Gtagttttga   Aattcagatt   Tttctggaca   Tgaaatcaaa   Cttgctgagc   1320     Aagcagcagc   Cataatagagc   Catgatgagg   Ctggcagggc   Agacgatgtc   Tgtgcccgac   1380     Attggagggg   Gccgtgtgtg   Gtggagcttt   Ggggaagttt   Atcttacctg   Ggtcagattc   1440     Tccccagcca   Ttgaggtttt   Ctgccaggat   Cgatgcctgg   Tacaggccaa   Gaggtgagag   1500     Aggtggggac   Aagacacccc   Gccccccttg   Acctcagctc   Ccctttcact   Ttgtgagga   1560     Tttgccaatt   Aatccctatg   Gactttagtt   Ccctaaacag   Agggagagag   Tcttgaacct   1620     Caggattagc   Caatcgccaa   Aatgtgtccg   Agtacgcagg   Gcactggaca   Ggctgtgcag   1680     Tacatcgtgt   Actcagctgg   Tagaaatgag   Gggtggttct   Ggcccctaaa   Ggggttttta   1740     Atctcagcag   Gatcataatc   Taatttctcc   Tccattggac   Catcaatctg   Ttgaggtagg   1800     Aacagtattt   Tacatctcgt   Aatcctgcat   Gttgttgcct   Ggcacattgt   Agttgcctcg   1860     Tagatgttga   Atgaatgaat   Aattgaaata   Gcatgaaaaa   Gatattaaaa   Agtcaaaaga   1920     Gcatgaacaa   Atactcaatt   Aatatagtgg   Aagccatttt   Ctctgaatga   Gcacaggtag   1980     Gggaattacc   Agggccaaat   2000       <210>   33   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   IFFO1     <400>   33   Cattctctgc   Ggattctagt   Ctccctgcat   Ccaattgctt   Ccaagctcct   Cattacacag   60     Cacaaacttt   Actctcattc   Ttttcacccc   Tgattcttcg   Gaacccacac   Caactcgcgg   120     Cccgttgtga   Gtggtatgac   Acagagagac   Ctgtccccct   Ttcccaatcc   Ctacctccgc   180     Ttgtactcgt   Cccgctcccg   Cttcactttg   Gccagcacgt   Tgtagagagc   Gcggatctcg   240     Ggcgtgatgg   Tgtcgatctg   Gacgcccacc   Ccatccgggt   Gcacccacga   Caagccaggc   300     Cctgtcacca   Gagtgggctc   Cagtcccggc   Ccgagccggc   Gggcgtgcga   Gaacgaccag   360     Atggtgccgg   Gcatgaagcg   Ggccgacgag   Gaataggtgg   Tggaggtgga   Ggtggaggac   420     Gacgagaggc   Tggccgcgga   Gggcgcgagg   Gggccggccg   Gggagcgcgc   Gggcgagccc   480     Agcacgcgcg   Ccgaagggct   Gcagacagcg   Gccggccggg   Cgcccagctg   Cagccccagg   540     Ggccggtagg   Ggctgacgaa   Gccggtctgc   Actgcctggt   Cgcgacgacc   Caggccccgc   600     Cggccctgct   Taccctcctc   Cagcgcttgc   Tgcagttgct   Tctccaacag   Ccggttccgg   660     Cgctccagct   Catgcacctt   Ggccaggaag   Cagcggaacc   Ggaggttcag   Ggtcttgagc   720     Acgttgatgt   Tggagcccag   Gtcattgcgg   Agggccatgg   Cggcaggcgg   Ggccgggccc   780     Ggcccgggcg   Gcgagtaggc   Agcagggccg   Gccggcgaga   Gaggcgccgg   Gggcaagtct   840     Cctcccccgg   Cgaagtggtc   Gcctcccagt   Gagtccccca   Gtggcccggc   Caggccctgc   900     Tgctcctgct   Gcaggaggaa   Gaggttgggg   Ccgaataacg   Gattcatggc   Tgcgccttct   960     Gctgggagat   Gcagaccggt   Gcaggagcag   Ggatggaagg   Cgagccagaa   Gagccaatgc   1020     Ggcgccggcg   Ggacagagcc   Gaccaatcag   Gcggctcggc   Agcggggcag   Aggtcagggg   1080     Gcgggccgag   Gggaagccaa   Tgacaggctc   Caattggagg   Ccggaccctg   Gacctttccg   1140     Ggtctgaggc   Cgagccctgt   Gatgagggga   Gccaccgcct   Ggactccagc   Cggggtggcg   1200     Taaagcccag   Gacctccagt   Accccatggg   Ttctggtggc   Aagcccatct   Cccctacacg   1260     Actttttttt   Tttttgagac   Cgagtctcac   Tgtcgcccgg   Gctggagtgc   Agtggcgcga   1320     Tcttggctca   Ctgcaacctc   Agcctcccag   Gttcaagcga   Ttctcctgct   Tcagtctccc   1380     Gagtagctgg   Gattacaggc   Acccgccacc   Acacccggct   Gattttttgt   Atttttagta   1440     Gagacgaggt   Ttcgccatgt   Tagccaggct   Ggtctcgaac   Acctgacctc   Aggtgatcca   1500     Cccgccttgg   Cctcccagaa   Agtgctggga   Ttacaggcat   Gagctagtgt   Gccccgcctt   1560     Cccctacact   Tctattgccc   Tcctctcccc   Ggagttcaat   Cacccctagc   Tctgactcca   1620     Gggctttccc   Ttcctgggaa   Aacccaagga   Tgcaggagcc   Taaaactgac   Cttatttctc   1680     Agtagcaccc   Aaccatcccc   Tctcctcaga   Agatcccagt   Cccacctccc   Atctttaccc   1740     Ttaaagcggc   Aaaggcagca   Cccagttccc   Tcaaaaatac   Tcagtggcca   Gaggttttaa   1800     Aatgtgtatt   Aaatttcatg   Ggtatgcaca   Gtagagaagg   Catcctcaca   Gaggcaagag   1860     Ttccaacctg   Gtgacaatgg   Cagtgagcca   Cccgtctagt   Tttcaaccat   Ctaagatagc   1920     Agcagctggc   Tgttgcccct   Ggactgagat   Ttcttcctct   Ttgctggtgg   Ggggcggctg   1980     Gaacggatgg   Gagacacagt   2000       <210>   34   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   KIAA1731NL     <400>   34   Ctgtctcagc   Cttcccaagt   Agctgggact   Acaggcgcac   Gccaccacac   Ccaggtaatt   60     Tttgtatttt   Tagtagagac   Ggggattcac   Catattggtc   Agactggtta   Caaactcctg   120     Acctcaggtg   Atccactcgc   Ctcggcctcc   Caaagtgctg   Ggattccagg   Catgagccac   180     Catgcccagc   Ctgcactggg   Ttttggactg   Gctgtgttag   Catcacctgg   Ggcaggggtg   240     Ggtcacgtta   Gaatgagtcc   Tggctaggcc   Cacagcaggc   Ttttccaccc   Gaatactggg   300     Gccacagctc   Atgaatctgt   Gtgtatccat   Atcctgggct   Gggtcagctc   Tccagggtgg   360     Agatggttgg   Gcaggcagcc   Tctgggggca   Agctcgggct   Caggcctccc   Cttgaccagc   420     Ttcacagaga   Cagacactga   Ggcagactga   Cctccaaact   Cccagctgag   Acgccagctc   480     Cccacgtggg   Gggcttacag   Ctgatgcaac   Cggtggctca   Ctaaacatac   Ctcgacagcg   540     Tccattaccg   Cttccctgca   Aacctcaaga   Tcctaagcac   Ccagcctagg   Tcaggggtcc   600     Ccaatcccag   Caggtgttcc   Tgcttcctga   Agacccccca   Gcccaactcc   Tccaacaacc   660     Atattcatct   Ccaacccagt   Cccaccagct   Tccctcactc   Tccttcccat   Cacactgcct   720     Gtggggagcc   Ccgtggtgca   Gggactttgc   Cgctggcctt   Gcgaacccac   Ggcttggagc   780     Ccctccttgg   Cccactctcc   Ggggccctct   Tgggagcctc   Gctaaacagc   Tgggcatgga   840     Aagaacccca   Ccctcaccac   Agatgggaac   Agacacagag   Agcctcagcc   Ccgcagtggt   900     Ctcaggggcc   Cactgaccaa   Aggtggccgg   Aatcgcttcc   Ccgcctccac   Ctgcagcccg   960     Gcctctgccc   Tggctggcta   Ctcatagcag   Gctgttgcca   Tgggaacagc   Agagctgttg   1020     Agctgtgaca   Tcatggcagg   Ggtgaggtca   Gggacagctg   Tgagccagcc   Agggggcaag   1080     Cgtgtaggtt   Aggggatcaa   Tcataaagat   Ttggctcaag   Cagccgggag   Ccatgggggc   1140     Acctgaaggc   Actgtttaag   Gaggtgtggg   Tgaacaagga   Cagtgcaatg   Tacaaatgct   1200     Cgtggccata   Ccaggcagag   Gacatctttt   Tgtccccagc   Tggctgcatg   Gagacctccc   1260     Agggtgtcat   Tctctctgag   Ctgtcaggcc   Attatagagg   Tacacttcaa   Ggtcagggtt   1320     Cctgacaacg   Cctgccatcc   Cttctcctgt   Agggacagca   Tctgttcacg   Cttctaaaca   1380     Gctccagaaa   Gccatcgtta   Aactgaaacc   Cactggaggc   Gggggaagaa   Agaatcccgt   1440     Caaccacctg   Cccacacagg   Aggagaagcc   Acacgtactt   Ggcctcgttt   Gaggggtagt   1500     Tccccacaga   Cagtttgatc   Gaagaggatgg   Gcgagggaag   Ctggcagggc   Gaggctgggg   1560     Atgaacatgg   Gacactgggg   Gagtctggcc   Ggtgcagggg   Gtttccagga   Agcaggagta   1620     Gctgctggaa   Atgggggccc   Ctgacctagt   Ctgggtggtt   Ggcatcttaa   Ggtctgtggt   1680     Aaagtgatga   Ctggcattgt   Caagatatgt   Tttttgtttg   Ttttttagac   Agtctgcctc   1740     Tgttgcccag   Gctggagtac   Ggtggcgcaa   Tctcggctca   Ctgcaacctc   Tgcctcccgg   1800     Gttcagggat   Tctagtgcct   Cagctttctg   Agtagctggg   Actacaggtg   Catgccacca   1860     Tgcccagcta   Atttatgtgt   Ggtgtgtgt   Gttttagcag   Agacggggtt   Ttaccatgtt   1920     Ggctaggcgg   Gtcttgaact   Cctgacctca   Agcgattccc   Ctgcctcgac   Ctcccaaagt   1980     Gctaggatta   Taggcacgag   2000       <210>   35   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LBX2     <400>   35   Ggcaaggaag   Tgaaggaagg   Gagggatgat   Tcagaggtgc   Agggtcaaac   Cttctggggt   60     Ggagcctttg   Aggcttttag   Gagcctcagg   Ctgagcaggc   Tataagttga   Gggtgacatc   120     Agaggcgagt   Aagagtcagg   Gcagccgacc   Cagcgtggtg   Gtggtaacag   Gacttagatc   180     Atgcccttcc   Atggatcggg   Tcgggcattc   Ggtttacagt   Tccttagtga   Caccagagcc   240     Cgctcctccg   Gccccaaagg   Gagataatga   Ggtacagaga   Gcgagaaaag   Gcagagtgcg   300     Gaatcccgcg   Cccagtgctg   Cgccaagggc   Tttctgctcc   Ttgactcccc   Tcgagaagag   360     Agtggcttgg   Agcggagctt   Ggtcacccgg   Aaagactcga   Ctctccagcg   Ctttctgtgc   420     Cgcctttgca   Ggctcactcg   Tttaccgcct   Gcggctgaag   Ccttttgtct   Ctttctctcc   480     Tgcctttctc   Tatcgcgatt   Gccccgccta   Caaggaacag   Agcaacaggt   Cgctcagttg   540     Gcgacggtct   Gcccttttcc   Cttggcactg   Gcggccttcc   Ggagccgccg   Cggaacctag   600     Ggactaacgg   Aggagaggtg   Gaagagtcgca   Ggtgcgagtc   Ctggcacgtg   Ggctgaggac   660     Aggggaggat   Tagggtgggt   Ggcctgggct   Gggacaaagg   Tttgagacgg   Ggaaccagga   720     Ggagagaggt   Gaggaaaagg   Ctaagtcaga   Gtccgcgacc   Ttgccggctc   Tataccttca   780     Gagggctgca   Gagcgcgcgc   Gtcaagtccg   Cggaaagttt   Tactagtcag   Ctcctccagc   840     Gcgcacagcg   Gcgacgttgg   Acccggaccc   Gactctggaa   Gctgcggcgc   Agagggtgct   900     Cgggggacca   Tgcgcggggc   Taggatgtct   Gcgatgctta   Agaggtccc   Gggtgttcgg   960     Ggctcgcgtc   Ccgagttcat   Ggtcggccgg   Gctggggcgg   Tccggctgtc   Cgttgcgcta   1020     Ggctccgcaa   Acgcctgggc   Cccagtgctc   Ggctcccaat   Ccgggccccc   Agcctcggac   1080     Ccgcccccgg   Ctctgggccc   Gagtcccgtg   Tgcccctcct   Cctgcgcccc   Cacctctcca   1140     Ccccgggccg   Cggtggatct   Ggagctccta   Gatgtccggg   Gagggtattt   Ctacaggctg   1200     Gggcaggcgc   Ggagagcaga   Agccgaccaa   Actacccacc   Agagcagggc   Cacggggctg   1260     Ctccgcgctg   Cggggcgctg   Caccgtgcac   Agtcaggccg   Ggccatacct   Ccagacgctg   1320     Tatgccgccg   Actccccgcc   Tagccgccgc   Tccggctcat   Aaactagtag   Acgataaaat   1380     Tgccttctct   Ggccccagcg   Gctggggatt   Tgcaaagttc   Tgaggaaggc   Tatcagggct   1440     Gactgtgctg   Ggatctctga   Tcccagctag   Gacctcagtc   Tcctaacctg   Gctccctctt   1500     Ccccaccccca   Cccctgagaa   Acgttgtttc   Tggtcctgac   Ggctggaagt   Gattagtgct   1560     Gcatgggtcg   Ggggcgcaac   Acttgggagg   Acctggcctg   Gcggagcgac   Tgcaactggg   1620     Aatagtgggg   Atgccacgaa   Gaagcaagca   Caggtgaatg   Gacccgaggc   Tgccccacct   1680     Gacgaaatca   Gaacacacag   Agaagctgcc   Gggagacccg   Ggccgcagga   Gagaagaccc   1740     Agggaactcc   Cagctggtgc   Aactgcccag   Gaggggtctt   Tgtcagtgag   Gactggcaaa   1800     Atcagtcgat   Tttgtctgtc   Tttatcttct   Ttttattaag   Ctcccatagt   Tcaggtatgt   1860     Atggtttccc   Cagcctgcag   Aggctcagaa   Actgccaagg   Ggagcaaggt   Gccctgacca   1920     Gagaggggtc   Actccccata   Gaagagagac   Ttgaagggca   Gacttcacgg   Acccagctgg   1980     Atcttgggac   Attcctgaca   2000       <210>   36   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LINC00925     <400>   36   Atacctccaa   Gggttatgtg   Agaattaagt   Aaaatatgca   Aataaagtgc   Ctggcataca   60     Gtaggcactg   Agcaaacggt   Agctcttttt   Tccaggctgg   Ggcaagggat   Gcatataaat   120     Gtctggatct   Gaagtttgaa   Attccacctg   Ctggagacag   Tgaacacccc   Agtagatacc   180     Ccaaatcaca   Cagaaggacg   Gatgaccagc   Tgccttcttc   Ccccagggca   Tgccatacac   240     Actgggcctg   Aagtgggaga   Atcgggaccc   Caaaaaaacg   Gcttgtggag   Cggggttgca   300     Catgggtgta   Aagttcccag   Cttggctgcc   Tggggagggg   Gagcatgtaa   Atgtctttag   360     Agatttgaag   Ggaccaggat   Ctggactgat   Ttgcgttgcc   Cagggggctg   Gggctgggag   420     Ccaagggggt   Gctgccggga   Ggcccaggtt   Agcttggggt   Atggcatttc   Taacagttgg   480     Cgcctgcgga   Aaatggcctg   Gggttccagc   Tctggaaggt   Tccgaatctc   Agtattcacg   540     Agcggcgctg   Tccggagcag   Ccagggttgt   Cccttggtgg   Tctcgggcag   Gttctccgcg   600     Atgcgcttgc   Tgggtcgcag   Gtgagaacct   Cacggttctc   Catttccgga   Gatccagctc   660     Tgagcaggca   Gagggtcgct   Cccgtcgcct   Gcccctgcgg   Tagccaagcg   Ggtggctgga   720     Agcgtggcta   Gctggcaggt   Aaggagctcc   Aggtgagacg   Gaacacgacc   Cccaaccccc   780     Ttagccggtg   Ccccaccccga   Tttctctcct   Gcgtcctggg   Agggcatggt   Tgaggcgcca   840     Ccggtgccca   Gcaacctccc   Caggctgtgg   Ttgtgacctg   Aggaggcgtg   Tgtccccgcc   900     Ctcaggccac   Cgctacgcga   Ccctgagtgc   Accttcaaga   Aggccgggca   Cgtttctggg   960     Cgggcgtggg   Gggtgcctga   Tatctccgct   Ctattttaca   Gttactcccc   Tgctggtgcc   1020     Tccctccttg   Gcgcgcttcc   Cacctgcgat   Cggcgccctc   Ttcgcagtca   Cgaactcgcc   1080     Agcagctagc   Agcactgact   Agtaggaggg   Cccgccggag   Gagaggtgag   Cgaccagagc   1140     Cagggagtgg   Gtggaggagc   Tggctgcccg   Cacccgcact   Ccgctccaga   Tgtctcagag   1200     Agtggactgc   Gggttgggag   Gttgggaaat   Tccaggatca   Ggttggtagt   Gcgcctgtgt   1260     Ttttacctgg   Gtcaccagca   Agacgactcc   Cctcctccct   Aggcccggat   Ccaatgtcat   1320     Ccctcaccct   Caacctgtga   Aatggcttta   Accatacacc   Tgctggcttg   Ttgtgctctg   1380     Tgacataatt   Tggcagaaca   Cggcgtgtag   Cacacagtgg   Gcgcaaagta   Aatggcggct   1440     Ctggcggttc   Tagcaccgga   Ggcggcttct   Tggacacccg   Gcgttcgcgg   Gagcctgagg   1500     Cgctcggttg   Ctagagcctt   Agctgggagt   Ggcgcggctg   Cttcccgccc   Gcgcaggatc   1560     Aggccggccc   Ccgcgggcct   Ggagctggat   Cgagagctag   Ggaaactgga   Aaaacaggca   1620     Caaactcgga   Agccgcggta   Cggcaagagc   Ctaagcaaag   Aatcctttcc   Aagattcaca   1680     Cctcgtctac   Accagggcac   Cgcctgggcc   Tacggccttc   Cgaacccgaa   Gcgcccgcag   1740     Cccagagctg   Gcatcaggcc   Atcaggccgg   Gaaggtcgtc   Gcaggcccca   Gagtgcgggc   1800     Gcggggggcg   Cgcgcccaca   Ggacgcccgg   Ggttgggtag   Gcaggagaga   Agggcgccag   1860     Caggcccgcg   Gctgtttccc   Ctcggtccgc   Acagcgggcc   Cgggaggcca   Ttttgagagc   1920     Gcgaagaggg   Gcggcaagat   Ggctgcgtgg   Gcacccggaa   Ggtcgccgcg   Ccaagggccc   1980     Gctgagcccc   Tcctcccatt   2000       <210>   37   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LINC01210     <400>   37   Caggcctctg   Tcgcccgagc   Tcaggctctc   Ctaggtgctt   Cagggccggg   Ctgcactcga   60     Gccccgagga   Ggccctgcta   Gcgctagcgc   Ggcggtgata   Accgagggag   Gtgggtgaga   120     Ggtgcggctg   Tcgaggcaaa   Cgcagagcac   Ccgcccagtc   Ctccaagggc   Cgagagccgg   180     Gagtcccgaa   Cgccgcttaa   Gcagctcctt   Gcttcccgca   Gcccgtccac   Atccctgcgg   240     Gatttctgga   Cgccccgccc   Ggggacctag   Ggaggaggga   Gagaggaggg   Agggagtggg   300     Cagcctgggc   Gcacgccacc   Ggtccccgta   Cgcccggcac   Cccccgtggc   Gcggcgagtc   360     Aatgggattt   Gcacactcga   Ggtgtaacag   Cattactgca   Ttaattacca   Tttccatttc   420     Acgtccagat   Tgtttactta   Tctgcgggaa   Acatatgtcg   Ggagaagttc   Acattccgga   480     Ttctgctccg   Ctgcccaagg   Tgcaattccg   Gggaggcggc   Gaggggggag   Gggagggctt   540     Cagatttttt   Attacaccct   Ctagccttat   Ctgccgctgt   Aaattatgag   Gatcctccat   600     Tgagcggcat   Atggagatta   Tatacttttt   Tgaatatcgt   Ttcccaaagc   Ctgcagattt   660     Tcactttgaa   Atgaaacaat   Cctccgctgg   Ttcccccggg   Gacaggcgtc   Tcctgcgttc   720     Ccccgcgcgg   Cctgggggac   Ccttctcgca   Gagcaggcgc   Gcaccccaat   Gccgtggccg   780     Gcgcccagtg   Gagacttctt   Tcacagggtc   Tagaataatc   Ttccgcggaa   Cacccatcca   840     Tatgcagtgt   Ttgagaacta   Aggcagctcc   Cttgctctgt   Tttcctgcgc   Ctagcccccg   900     Gacttttgtg   Ccgtttgcag   Ctctttttca   Tttcgaatac   Ccgcatagac   Gcgagcccac   960     Ttctgccctc   Ttcctacgct   Gggcggctcc   Aaacccgccg   Cgagggctga   Ggtgttcaca   1020     Cctgcccacg   Gcagcctgcc   Tcgccctcaa   Gcgcctcaaa   Gcttcctaag   Cgcttacatt   1080     Ggtcttggga   Cagccgactt   Tggcttcttt   Gtttgtttga   Gggaccgcgg   Aagtggcggg   1140     Gaatgtgccc   Ccgcttgaga   Ccgcttattg   Tgagccctca   Acggaaatcc   Tgcacggaag   1200     Gcaaccgcct   Ccccgctcgc   Ggtaagcagg   Atccacccga   Gtagcgggga   Ccgaatccca   1260     Tctttcttat   Ctctcgaaga   Ctcctttcag   Gctgagatca   Gagagggagg   Gaaaaagaag   1320     Agagaatcat   Tgttcttctt   Tttttaattt   Aatataccaa   Gccaccagct   Caggtcattt   1380     Atatgcttaa   Tttagtgata   Aaagtcaata   Agcggaatca   Cagggttctt   Ccctctttct   1440     Atttcttttg   Accacatttt   Tctacagtaa   Ttgggaaaac   Cgtaaaatat   Atacacccgc   1500     Tttccgcctt   Caatgctttg   Tctgcaatgc   Gattataata   Agtgtatttt   Attatagtaa   1560     Tttgtttgct   Tttttgaagg   Atgcaaggga   Aaatgtgcct   Tttaggagat   Ttttttccat   1620     Cttatctggg   Ttcagtttgc   Agaattacac   Atactctgtg   Tgtacacact   Caccctcaaa   1680     Agccaaactc   Agaaatttcc   Ttgaaatgcc   Cgtttttatg   Attcagaaat   Atcccgtggg   1740     Aaacctattg   Tgatgttata   Ccaggaacaa   Ttaaatggac   Caaagcaatg   Caattaaggc   1800     Agagaagaaa   Taagatggaa   Aatggggaga   Aataaacaga   Ttcttttcca   Ttaagtattg   1860     Ttttgagatt   Tctaattttt   Tcaggacctc   Taagaaaatt   Gtgaggtgtc   Acttctctct   1920     Tctgggtcta   Tctgtaattg   Aatctaggtc   Actattctaa   Ggcaagaaaa   Gtctgctttc   1980     Cactttccta   Catcaggctg   2000       <210>   38   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LINC01475     <400>   38   Aaactcagat   Caaccttagg   Gatgcggtag   Cggatagagg   Ttttccgcag   Gctggaacag   60     Cactacactg   Ggctgggtat   Gaggaaagga   Agcggcgata   Aggtctaggc   Gccgcccgct   120     Aggccccttc   Gcctggaagt   Cctcacaggc   Cctggtggcc   Tactgaggag   Caacctgccc   180     Agggtcctca   Agagacaacc   Gcttaggcct   Ggcgcaaggt   Acctggcccg   Ggagcggctg   240     Gggcggcgga   Atttggggta   Gaggggcacc   Cgtgggccgg   Ctggtgggga   Ggagacagcc   300     Ccctgcatga   Gctcacagag   Gcgccctggt   Gggctccggc   Ggctgcagag   Cgtctgtggg   360     Cgtgtattgg   Cgatcaggcg   Ctggaggggc   Gctttgtcct   Ggtcgcagtt   Ttaagacctg   420     Gattgttggg   Ctagatttat   Gaaaggccta   Ggagcgaagc   Gagatgggaa   Gcaagggaat   480     Gtaacaagga   Gaaatgcagg   Cttcggttgg   Aaactgggga   Gagagagatt   Gtttcgatag   540     Cctttctcct   Tttctttttc   Cagaatcatg   Aaatcaccga   Ggagaagaaa   Actggggact   600     Agaagagagc   Agaaacattt   Cccctgagac   Agttttgccc   Cggaggtggg   Gtggggaagt   660     Ggcgctggag   Ctcagcttcc   Tgcttttatg   Ctcggcggcc   Accgtgatgc   Acacacactc   720     Gaggtccgcc   Accccgcagt   Gccgtgcacc   Cctctgcccc   Cacctcggaa   Tttttgtgcc   780     Cgagcgctcg   Gtagcccagg   Caaaaccagg   Cacattcctc   Cctctgcaga   Ctcaccgcct   840     Ggtttgtaga   Cactggtctc   Cgcctggggc   Gtcaatagtt   Tcaggattta   Aagcagaaag   900     Acaccgggcg   Cccctgtggc   Tgaggaatgg   Cggttccagc   Acaagaccct   Gcccacagag   960     Ggtctctccc   Tactgcctgc   Gggccgccgc   Taccctaagt   Actccggggc   Gcacgtggcc   1020     Cgcgcggcat   Cccagctccc   Cgggcggacc   Caggggctgc   Ctctccacaa   Cagttccgct   1080     Cccttctgca   Gagccccgcc   Tctcccacct   Cccgacaggc   Tgttctttct   Cccttcaacc   1140     Ttgggcaccc   Actcctgtcg   Ccgttgcggg   Acccgcgtgg   Cagccctcca   Ccctcgtacc   1200     Cactcccagc   Cggtgtctta   Tgccgctcgg   Aggcaatgtc   Caccgtccct   Gcacctttca   1260     Cctgcccctt   Ccaggtgaga   Cgggtctctt   Tcagctccgc   Catcctgacc   Gccaaaaaat   1320     Gcttggattg   Gctggggccg   Gatgaggaca   Gccacggttg   Agctggaacc   Gttccctatt   1380     Tttttaaggc   Cagcgctgca   Cacgggtctt   Tctgtggccc   Tcaaagcagc   Gcccgctgct   1440     Cctcactggg   Ctaggcctgg   Tagcgagcaa   Atgcctattg   Tgggagaaga   Tggtcccaga   1500     Gtttccagct   Cagagtttcc   Agaatctgtg   Ggggactgta   Tagactcccc   Cagaaaacaa   1560     Ccaggggctc   Atgaaggtgc   Cagaaggcgt   Gtaggtagag   Aaattttaaa   Agcctgtcgg   1620     Agaggcaagg   Cctacattca   Ggctcctgat   Ttcaataggt   Ggaaaagaag   Gctgccaagg   1680     Ctgggtcacc   Tcccttgtga   Ggacagatcc   Tgctctcagt   Atgtgccaca   Ctccagccac   1740     Gcaccaccaa   Tgcagtcaac   Aaacactgct   Tgacctccca   Tacagaaaag   Cagtcgttga   1800     Cacgtactga   Gcgcttaaca   Cgcgtgaggc   Cgtgcactaa   Gattctggca   Tgttttgcct   1860     Cattcaaccc   Tagcaacaac   Caaaaaaggt   Attactgcct   Tcgttttata   Gacgagaaaa   1920     Cagacttaga   Aacgccgaag   Atcacacact   Gactaggcca   Agcaagagct   Gtcgaatacc   1980     Aaagtttagt   Cataactcta   2000       <210>   39   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LOC100130872     <400>   39   Ggagcgggtc   Aggccgcgag   Aggcccaggg   Ccaggctggg   Gagcagagct   Gctcagcggg   60     Gcagaggtcc   Tcctccgggc   Gccgggctca   Gggcccagtg   Gccagatggt   Tttctttgct   120     Gcagggagtg   Ccggctgcgg   Gggtaggcct   Gggagggctc   Atgcagctgc   Tcttgggttt   180     Ctctgctgtt   Gttttttgct   Ggaaaatcaa   Tcctgcaagt   Ccagctgggc   Tctggctgag   240     Agcagctagg   Ggtggggatg   Gtgggtgctt   Cccggccccc   Acggggcaag   Ttctgggccc   300     Acagtgggga   Gagaaggcag   Gatggggtgc   Agggccagcc   Tggggtgggg   Ccccgaagag   360     Cctggctccc   Tgccctgtgc   Cctgcttggg   Ccaccccaga   Gggactgtcc   Cgaccctccc   420     Aacttcctgc   Caaggccccc   Ggagctgcct   Gcagcctccc   Cttgctcccg   Tgcccggggc   480     Ggaagtctac   Aggagaccag   Agcccgggtg   Ttcatcagca   Gccgcaggag   Agttccccac   540     Caaggcgcag   Tagcctgagg   Tgctggggct   Gcccgaccct   Ccccagctcc   Acccctcttg   600     Cctctgagcc   Ctacccaagg   Cctggagaat   Caccgcttcc   Tcctgctcca   Ggggttccag   660     Cagggccctt   Ggaggatgtg   Cctgccgcgt   Tctcagccct   Ctctgccgac   Ctttcttgaa   720     Cggactctgg   Ccacggtgcc   Aacgcgtcaa   Cggtctgtcc   Gtctgctgtc   Cgagctcagg   780     Ggccgtccat   Gcctccacgg   Ctggcataca   Gtagctctgg   Ttttacccat   Gagggggaag   840     Cccagcaccc   Gtgccctcga   Tcacatcgcc   Agttcacaaa   Cacacatgcg   Cacacgcaca   900     Cgccgcccgc   Ccaccaggca   Gacacccaca   Cacctgtgca   Cgcacgcgca   Cgccaagcca   960     Gcgggccctg   Cccctgcccc   Ggagccctca   Gtgtcagaac   Caggctgctg   Tggctgtttc   1020     Ctctttaatt   Cgcctgagtt   Tttaggccc   Aaattcatag   Acctttgttg   Ctgcatataa   1080     Acttgaggat   Aaacttgttg   Aatttgttca   Acgtaagcag   Ctgaaattct   Gcgtggggtg   1140     Gtgatgaacg   Gctctagcac   Tcggtaaaag   Gttatttaaag   Cgcatgtagt   Ttacaacact   1200     Aacagcccgc   Cgcccgcgag   Cacagcccgt   Ctggtcatcc   Ggcggcctca   Ccgttcacca   1260     Cggttggcgg   Ccctggtcac   Tcccacggtc   Tttaccagcc   Gggtgccagt   Ggctgggacc   1320     Aggttctgac   Cactgtgccc   Actcactgtg   Gaatcgcgtg   Agcaggccag   Accctgcgtc   1380     Gtaaggacag   Agcaggacac   Gtcctgtcat   Ggggcacccg   Ctgtctgcga   Ctttgtttcc   1440     Gtttgtttcc   Gcctcagctt   Gggggagaca   Gttggcaggc   Accagaggcg   Ctcctgtgag   1500     Gtcacctggc   Cagtctcagg   Attagctgca   Ggctttggct   Gattttcttg   Ggtcttgtac   1560     Acagatgctt   Gtcagcaaat   Accagagact   Tatctcttcc   Cttccaacat   Gcaaaccttc   1620     Cttcatgttc   Ttgtcttaag   Cgttttggca   Caacctccag   Cctaatacca   Gcctctaggg   1680     Agataaacag   Tgctgccgat   Ttcacaggcc   Aggaaaccga   Ggctgagggc   Cccccaccca   1740     Cctcctgcta   Ccccgcaccc   Ctcctggggc   Cttgctgggc   Ggggtgactc   Cccggaggcg   1800     Gcaccaaggg   Gaggttcgtt   Tcgaggctca   Gagcactttt   Ctgacagctt   Tctgtccctt   1860     Acatcccaga   Ctcagttaca   Cttcagcgtc   Ccggctccct   Ggccgccagg   Ctcacaccac   1920     Agacagccct   Tggaggcatt   Ccattcctgc   Cccgaccctt   Caacttggaa   Acatggaaac   1980     Aatgaggcca   Gctgagtggg   2000       <210>   40   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LOC283692     <400>   40   Gacatgaaaa   Agcctcgggg   Aatgacgccg   Ggtgggacac   Cccaaggtga   Ggaccccttt   60     Gtgggtgagt   Ccccccacac   Tcaggtgact   Ccaggcgggc   Acaggcccgc   Ccaaccgctc   120     Gtcatcacgg   Ggggcgactc   Gtccagggcc   Ccagccgctg   Ctccgccaaa   Cctgaggccg   180     Cccctgagtc   Tgggcacctg   Gcctcgtccg   Gcactgagga   Gaatgaccag   Aacgccaggc   240     Cacatgcacc   Cactcgccag   Gctgagggtc   Cgaacagcac   Agcccagagt   Gggctcgggt   300     Cgctccccgc   Ctacgccacc   Tccgcggcct   Gcaagcctaa   Ccctctcccg   Cccatgacca   360     Ggacccacct   Caatgccgcc   Agcccggcgg   Gtctcccggg   Cacgaagccc   Cgccagtctt   420     Ccgccctcgc   Gccacactac   Ctggccagcc   Ccgcccccga   Gactccctct   Ccggcgccaa   480     Gcgaaggtgt   Gaagccacgt   Gacctgccca   Ggattgggaa   Gccgcacgag   Gggcttgagc   540     Cctccacctt   Aaaggtgccg   Cgaccgccgc   Cgtcgtgggg   Ctctccacag   Agcacggggt   600     Ctacgccgtc   Agcagccccg   Ccccgtcccg   Cccgggcgcc   Cccaccgcgc   Gccgggtgct   660     Aaagagaccc   Gcagggggcg   Tgagcttcca   Gcgccagcgg   Cttcgggtct   Cccgtgcgac   720     Ggcagtgtga   Gaaagaaacg   Ttccgggcgc   Cggtgctcct   Tttagtccgg   Tcagctcccg   780     Tctggacaga   Cgctcgaggc   Cgcctggagg   Ccgcagtgcg   Gctcggaggc   Cccaccggcc   840     Gcccccgcag   Ggctgcggcg   Cctttaagcc   Caaaggccct   Gagtcacgag   Gaggctccct   900     Gcccccctcg   Ccctccaccc   Ctccacgagg   Ccccacccccc   Gcgggcacgt   Gaccgcgccc   960     Cgcccgggac   Tcgcccgcac   Ggggcggggg   Atgggggtac   Cgcggcgccg   Gacccggctg   1020     Cgcgcggacc   Gttagctact   Gcggccggga   Cgcggccccg   Cccaggcgag   Cggcgggtgg   1080     Ctcttaccag   Cgggaacgcc   Atggggccgg   Tgtggccctg   Cggggctgac   Gggctgaccg   1140     Gccagccggc   Gggcgagaga   Cgcgcacgca   Cgtgggcact   Atttttgcag   Cgggccgcgc   1200     Gcagccccgc   Accccggcag   Cttatgaagc   Tcctacgagc   Cgctcctcgg   Agccgccccc   1260     Cggccggatg   Cggagcacct   Gtgtcggccc   Cgcccgggcc   Ctcgcctccg   Ccccctcgcg   1320     Ccccgcccct   Cctagcaggc   Cgagccgagg   Agggctccgc   Cgcccacccg   Gaacccggcg   1380     Gggactgccg   Ccgctgctag   Ccacagctgc   Cccctggggg   Gccagagacc   Taagcctgag   1440     Cgcgccatca   Cctaagtgac   Ccttgccgag   Tcactgtctg   Ccctgggcct   Cagtttccct   1500     Cttaacgaaa   Gagggcacga   Tttacaagcc   Cctgcgagcg   Gcggcgatcg   Cttcgtcagt   1560     Agagcctcgt   Gtccgcgctc   Cttctcttcc   Agtgatctct   Ccagggcgag   Agcctgccct   1620     Ggcatccttg   Gtcggaactg   Tagcccctgg   Gctccaggag   Gcgcactcac   Tttagaccct   1680     Ctgctccgtg   Cgctgcagag   Ggggccgcga   Gagtcaggaa   Gttccagaaa   Gttccaaaga   1740     Catcactggt   Cctctttgga   Ccggagttct   Ccggagaaac   Cgcttccggc   Gctcctgaca   1800     Cactgagata   Gaaagtttca   Cagaaatagg   Gcaagggata   Gggcgagggc   Tccagggcag   1860     Gcgtcctagg   Gcacctggcg   Caggggcgga   Ccggaaaccc   Caggcaaacg   Cagagtcgga   1920     Gatggcattc   Caggcggaag   Atcaagcaaa   Ggcagagagg   Gaggacggca   Ccgagcggct   1980     Ccctctgacc   Aggactgagg   2000       <210>   41   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   LOC440982     <400>   41   Agtggttgcc   Gacagattcc   Aatcctactc   Tagattttta   Ctttcatttg   Aacaggtaga   60     Cccactttgt   Ggagcttatc   Atttcatttc   Cctcactggg   Aacaggatgc   Ctaggtcagt   120     Gccgggctca   Cactgcagtc   Tatcccaggg   Ccagttccat   Ctgtgccagt   Tttggaatac   180     Cgggaccaca   Gtatcagttc   Acccgacaac   Taccactccc   Caagccttca   Gcgtggaacc   240     Tgaggacgca   Gggagggagg   Ctttggaaat   Gttcctgcca   Ggacagtgcc   Ttttttccta   300     Cccaaactcc   Cgagtctccg   Agctcaataa   Cgcaaggatg   Gctgaagagc   Gtctgctcca   360     Tgtctctttg   Ccggactcaa   Cgaccctcac   Ccactgccac   Cgagtgctag   Gcccacagag   420     Gcctggcaga   Agccactcac   Ccctcactac   Tcatgactag   Gaagaaagtg   Gccggggcat   480     Gagggttcga   Gttctgtcct   Aggtcccgga   Agccagggct   Cccagcgtct   Agtcaggggc   540     Gcagaaaccc   Tcgttcctcc   Aaacccccgc   Cacagggacc   Actccagaag   Aaacccattc   600     Gtgatttggg   Tccctttgtg   Tttgagtatt   Gtggggagtg   Ggctatctag   Actctaagga   660     Ctccaagcta   Acgatgacct   Gtgtgggcct   Tgctctgaac   Agaaaactca   Aactcagcgt   720     Gggttcccgc   Gtcttcccca   Aaaggccaag   Gcccaaagaa   Cccttttcat   Ttggcgaggg   780     Gcttgaggaa   Gggaggggct   Ggggcgggag   Agggtcgggg   Tctgcaagcc   Agcggcccgg   840     Cgcagcggac   Ttgtccggct   Gctcagcttg   Gcagctagcg   Tccgtgccgg   Caacgctgtt   900     Accctctcct   Gggctggaga   Gtggggacat   Cccttccccg   Cccctaggcg   Tccctggggt   960     Cggcgccaga   Gcccgggagc   Gccggaggct   Ctggctggat   Ggcggcgagg   Agggctctga   1020     Gtcctctccc   Ggccaggccg   Agcttagtat   Gtggaggcgg   Cggcgggagt   Gcgggcatgg   1080     Accaagggaa   Gggggacacc   Caaaccgcat   Tggtgccttc   Ctttccctcc   Actcgcgccg   1140     Tagacctccc   Caaattgccc   Gtctccggta   Tgactgaatc   Tgtctgctgg   Cctctcagct   1200     Accaactctg   Cccgaaatct   Agatcccaga   Cctggtaagt   Cgcgttcctc   Ccctaccccg   1260     Ccccgccacc   Ttactagcgg   Actctgcccg   Cgacagcgtg   Cgcgcgcgtg   Gcctgaggcg   1320     Cgcgctgaga   Agttgggctg   Atttggaact   Gctgcgctag   Ttcggcctct   Gccgctgggg   1380     Tgtatacgtt   Tatacgccgt   Acgctccagg   Gtagtcagga   Atgtcgcggg   Gctccccagt   1440     Gaggcgggag   Cgaaaagagt   Gcaggcccac   Tcttctggat   Cctcttggcc   Ctgttgacac   1500     Caaagccatc   Ttttaagaat   Aagctttctg   Ctggtctcta   Aaaggggaaa   Ggggcagcgg   1560     Gggaagagaa   Ttgtcccttt   Ccctaagcag   Tttctaatca   Ctaaggtctt   Caacaaagtt   1620     Tactgggcgg   Tttccatttg   Aatgctgtga   Aattgttatt   Attactattt   Taagttaagg   1680     Tttctaagag   Tcacagcttc   Tcaaatatac   Gtgcctcttg   Agtaggcttc   Gacaattacc   1740     Ttgtccacta   Actgcacttc   Cttcccactg   Gaaaaaataa   Acttaatttt   Tcagtagttg   1800     Ccttaggtca   Cgtcgtttac   Atgtcactaa   Tgtgaagaaa   Gaagtaaata   Aagaaaaaca   1860     Accttggcat   Ttctagttgg   Agctccgtgc   Gctttattat   Tgaaatgtga   Aagatggatt   1920     Ttggggtggg   Agggggaggt   Agggccctgg   Aagagggctt   Ttgaaccacg   Gtgccctgtt   1980     Gcaaggggct   Gacctttggc   2000       <210>   42   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   MIR124-2HG     <400>   42   Aaattacatc   Atttaaaagg   Accttggagt   Ttataaataa   Attaatttttt   Gatctttatt   60     Catcagattt   Ggctataaaa   Tgaaactgca   Gttctttgaa   Tgtgcaggtt   Gctggaatta   120     Gatgctacat   Atattttgaa   Cacacatact   Tattttaata   Ttttagtttt   Agacaacgta   180     Ttcaaagtac   Ttgagaagaa   Tatgcaatga   Cattttttcc   Gtgtcctaat   Caggaccatg   240     Gtgaggtccc   Cgtggttcac   Cgagtggtgg   Tccagggctc   Tggttgggac   Gctgagttag   300     Gttggcaaag   Cgtcattgtt   Ttgaaaggca   Cattcgtccg   Gaatggcatt   Cgtgataaga   360     Ttaaacataa   Acctaaacct   Tggcctcggg   Ggaaggcagg   Ctgcggggtt   Gagaagagga   420     Gatgcagatt   Agctctgctt   Ttgctgcttg   Cgcacataat   Taagaggcgg   Tccctcagct   480     Ggagcgtggg   Ctgtgtccgg   Cctaaggtgc   Ttattttcct   Gttacttggc   Caaccgagtg   540     Tgagtgaaca   Ggagcccgag   Agcttaaatg   Tgggatctag   Ataaggtgtc   Gactgggttg   600     Tgggcgtttg   Tctccatgtt   Agggagaggc   Aactgagaac   Ggtgactttg   Gcttgttttg   660     Agagagcctg   Ggttttgaca   Gcaggacggc   Gaagggagcg   Cttggagagg   Ctggaagctc   720     Gacgtcttag   Ggagctgcct   Gcgggcactg   Ggttgacgcc   Aagaggttgt   Cggcaagggc   780     Agggctcttg   Ccctctgctg   Tacctaggct   Ctgcaactgg   Gggctgcgag   Ccttctgcgg   840     Ctctttggtt   Tcaaggacac   Agcgagctgc   Tcaggacttt   Gggagccaac   Atctgtctga   900     Ctggtgacgt   Cagcagcccg   Tgtaatcctc   Ttgtgctgaa   Ggcagatgcc   Tttattgttt   960     Ggctggagcg   Agccattaat   Ccctaattct   Ggatcagcaa   Gcgaggggga   Aagaccggac   1020     Cgctccgacc   Caccccctcc   Ctacccccac   Ctcccacctt   Aaagcacctt   Ataccacgga   1080     Aggctctcag   Cctcttcttt   Cctctgcgaa   Cgcgctgagc   Agcgattgaa   Aacgttttgg   1140     Tcctctgcag   Gtttgaacag   Ggctagcagg   Tctctctccg   Gatttctagg   Gctatgggta   1200     Tatgtaattc   Tttctctcat   Cgatcgtttc   Gattctcttg   Ccggtcttgc   Agtttgcagg   1260     Gtcctaaacg   Aagaggggtg   Gagattcgag   Agtgcgggtc   Tggcgtgtgg   Tccaagggag   1320     Ggggtgaggc   Tgggaaaggg   Ggtgcagaat   Gcgggaacgg   Ctgggactgc   Acagaaggac   1380     Catctgcgga   Ctcgttttca   Ctgctccagc   Tcccgaaatc   Gtttctctgg   Acgcggcagt   1440     Atccgcagcg   Catgcaccct   Cctctggact   Tccgcagccc   Agacctgcgc   Ttacagtcat   1500     Cgcgccaccc   Cctccccccg   Ggctgcgggc   Cccgcgctcc   Gtgggctcag   Ggtcccctcc   1560     Gcgtccccct   Gaagcctggg   Gagggaggtc   Gcgaccggcc   Gactggggtc   Ctgtcctctt   1620     Gtcaccttgt   Atccctcgca   Tgctccctcc   Cgcctcgtgt   Ccctctcccc   Accctccccc   1680     Tcctctctcc   Cgcctcccta   Acactgcgct   Ttgattctgt   Ttttcagggg   Cgcattctgg   1740     Ggtctctgcg   Caagaccagc   Tctcagctct   Ctctcctttc   Ctcggactct   Ggagcgggag   1800     Cgggcctttc   Cctcgggtcg   Accacgccgt   Aggggacgcc   Gtgaaaagag   Ccgtcgcgcc   1860     Cgctgcctcc   Tgcccgctgc   Gcagagggct   Ccgcccgtag   Aggtcaactt   Ccctcaccct   1920     Tttctctctc   Ctgcttgccc   Tccctccgcc   Cggcccaggc   Gcttccagcc   Ccagactgtg   1980     Gccactggct   Gaggagtgcg   2000       <210>   43   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   MKX     <400>   43   Cgatcaaacg   Acggctacgg   Tctgtgttcg   Tagggaagtg   Aagtcagacc   Tctgctggat   60     Gtcgtgtgtc   Ccctaggact   Gcgtcctccc   Gcgcagacag   Gtacgtgcct   Ggggtgtgca   120     Catagcctcg   Gtgataagtg   Tcaaagagaa   Ttttcgtgct   Tgcagcccct   Gttctacagt   180     Caagactcgc   Gttggtgttt   Tcttttaaaa   Tcatgccctt   Agggatgtgt   Gttcatgctg   240     Ctttatttgt   Acaagacacc   Cttccccggc   Ccggccttct   Ccgagccacc   Ccaggccgtc   300     Ctcctagatg   Cgacgacgtg   Tttttcctag   Cgaagtcatc   Acgaggttag   Ccacctcgga   360     Cacttccccg   Gcagccccaa   Gcccacgcag   Agatcgcaga   Cacagacacc   Cggcgcgctg   420     Taggtctgca   Ggcagcaggc   Tcagaggcaa   Gcgatggcaa   Aggtccgagc   Gctgtcctgt   480     Cgcaaggggt   Ccgggggcgt   Gtgaaccaca   Cttgctgacc   Ctcccaggac   Tcccgcgcgc   540     Ggccacccgc   Gcctcttctc   Aaatcactta   Ccccgattca   Ctccagactg   Tggccgggga   600     Ggtcactccc   Tgcagaagtg   Tccccctccc   Ccaacgccgg   Cgaataattt   Taaagcaaag   660     Gaggcgcggc   Caggtgggct   Cccaagctcc   Gcgcagaccc   Ttgggccagc   Cttggccgct   720     Acccgagcgc   Ctctccacca   Gaccttggag   Ggaagttggg   Ggaagggcgg   Gagagcaccg   780     Gcgcccaggg   Cgcaggggcc   Agagcgagcc   Tggcgttccg   Ccgcagccgg   Ctgagactcg   840     Gcgacgcggg   Ggctgtacct   Gtggctgcgg   Ggccgacggc   Cggctgcagg   Gcggctggct   900     Ctcccgcctc   Gagactaggc   Gcactcccat   Ccccgccgca   Tgttctccac   Gcgggctcca   960     Gcgcgctcac   Caccgccacc   Gccgtcgtct   Cggctttatt   Tacccagccc   Ggcgcgcgcc   1020     Gcccgggaac   Aggaatagcg   Aggccttctc   Atgtttcctg   Actgccggtc   Ccaggccggg   1080     Aacatcctgc   Gggcgcggta   Tccacgttcc   Cgggcgggtg   Gagaggaagc   Gtccgcgccc   1140     Gcccggccgc   Gggggctgct   Gttaacccct   Agcagaggag   Ccgctgccgg   Ggagccccgg   1200     Gcccgccgag   Tcctccggag   Ccgggcgcgg   Ctcccagatc   Cgccggcctt   Gcagtcgtgg   1260     Agcagacggg   Gcttttccct   Tcgcacttta   Ggagagaaat   Tggagaagct   Gccgggagcg   1320     Ctcggctccg   Gctccagaag   Ctgagaggct   Gcggtgcaaa   Tcccgtgtct   Tagctggccc   1380     Gattgccgga   Aatttcactg   Cgcgtggcta   Ggcgggagag   Gccactgtga   Cgcgccctgt   1440     Attttcctct   Cgattagctg   Gagggaagtt   Agagctccgt   Tttgcaccta   Cagccctgga   1500     Gcgtattgcg   Ggaagtgcta   Gtgcccagga   Gcctcttttc   Tgatgtcact   Gggcttctgg   1560     Ggtcctagtt   Gtctcagtca   Aagccaggca   Cacattcacc   Tccggggcaa   Gggctggtga   1620     Ggctgccctc   Gccgctgggt   Atagggatgg   Gggaaagcaa   Gtaggggatg   Agttcagccc   1680     Aggtggccaa   Cccgcggtgg   Cccaagtgca   Gaagaggaag   Cgcgcccaaa   Gccaaggatc   1740     Tgcacgcagc   Aaaggagatg   Gaacttagaa   Gaatcacaag   Ctgggacaca   Gggcaaagag   1800     Agagaatggc   Taccagattc   Tctgattgat   Gatactttgc   Ttcctaacat   Taccgcaaat   1860     Atagagtagc   Aaagcggcgg   Tttaggtgca   Actgcaagct   Cagagcttct   Ggcagcccag   1920     Aagatcccca   Aggtgccaac   Acgaagctgc   Ctgcgctctc   Gccgaaggcc   Ctgtggtcct   1980     Agcgaacttt   Cgcccttttt   2000       <210>   44   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   NEFL     <400>   44   Aagctgtcga   Tgcgcttctc   Gagctcggcg   Cgagcgagcg   Ccgcctcgtc   Ggcgcctttg   60     Cgcgcttcca   Tcagccggcc   Ctcggcgtcc   Tcgcggctca   Gcacctcctc   Ttcatagcgc   120     Gcctgcaggt   Tgcgcagggt   Ctcctccagc   Ccttcgcgct   Cgccctggag   Cgcctgcttc   180     Tcgttggtgg   Catcttccgc   Cgccaggcgc   Aggtcgcgga   Tctcctgctc   Gtacaggccc   240     Cggaagcggg   Atggctcgga   Gtgcttctgg   Cgcagcacca   Gcagctcggc   Ttccaggacc   300     Ttgttctgct   Gctccagctc   Gtgcacgcgc   Tcgatgaagc   Tggcgaagcg   Gtcattgagg   360     Tcctggagct   Gcgccttctc   Ctgcgtgcgg   Atggacttga   Ggtcgttgct   Gatggcggct   420     Acctggctca   Ggtcgaggtt   Ctccagactg   Ggcatcaacg   Atccagagct   Ggaggagtag   480     Ctgcggcgca   Cggacagcga   Ggaagacacc   Ggcgccgagt   Agctggagta   Agctgagcgt   540     Gcggtgctgt   Agccgctgcg   Cacgctggag   Atgtgcaccc   Ggggcgtctc   Cacgtagcgc   600     Cgcttgtagg   Aggtcgagta   Gtaccgctcg   Tagctgaagg   Aactcatggt   Ggcggccggt   660     Ggctccccgg   Cccgcggcgg   Cggtgggagc   Ccggagagag   Aggacapggg   Agagagggaa   720     Gggggaggat   Ggatggctgt   Gtgcggctcg   Gcgccgttct   Gccaccccta   Tttatacgcc   780     Gggaggctcc   Tgacgcagcc   Tgcgatcgat   Cacggcacgc   Cggccagtgg   Gggcagcgcg   840     Ctgctgcagc   Caaggcgagg   Attctgcgca   Aaagggaagg   Cggggtcgag   Ctacggcccg   900     Aggagctgcg   Gcggtcgtcc   Tttccacttt   Gctcagaggg   Ccctgatttt   Ctctgagatc   960     Ccatgccccc   Tcactcattt   Cccttctgta   Ctcactcacg   Cagcccctcc   Cgtcctgcat   1020     Tgcccagacc   Ccgtgacact   Tggatcctta   Agttgccccc   Aaaacaggtt   Cttgctccct   1080     Tttgacaccc   Tagttttctg   Tatcccgtca   Cctcgcagac   Accctgtccc   Cccaactcgc   1140     Ccttttccca   Ccaggaacct   Ccttaatttt   Ttcccttggt   Gtttacggtg   Atggtgcggc   1200     Tagggaattt   Tagatacaaa   Taaataggct   Aggttatgtg   Tatgcagtat   Gtatggagaa   1260     Gagttttaat   Ttctttctag   Ctttctggca   Ctttctgcaa   Ttcatcttcc   Tttctcctga   1320     Ttatttttct   Ttttctttaa   Tgagctgctt   Aacacatagg   Gaatgtgcgc   Gcgagtgcgc   1380     Gcgcgcgcgc   Gcacacacac   Acacacacac   Acacacactc   Gtgaaactgc   Ggcactactg   1440     Caggtattgg   Tttagcattt   Ttaaaccttt   Acagcagtta   Atccgcctgt   Tagtgtttct   1500     Agattttcac   Atttcttaac   Tgagaatgaa   Gccgcagatg   Gctttaacgt   Gttgcagtgt   1560     Gtgggtggtg   Gagggcagag   Aaagagttgg   Aaacacagag   Actgacttgc   Tgaggcagcc   1620     Gcgcgctccg   Cagccgggag   Cttcaagctg   Cctggatcct   Caccaagcta   Aattcctgct   1680     Tgctaccacc   Aaccgcagca   Catttaaagt   Ccgctttcct   Ctttttacac   Atgtgtagca   1740     Cacgacctga   Tgatttcgat   Aagccttgca   Gttggctgat   Tttcagggaa   Gccgctgcgg   1800     Ccagccctga   Gcgctgggtg   Tggtctctgg   Ggaggagaac   Tcggcaccca   Ggcttcttca   1860     Ggaacggata   Gaaaatagcc   Atagccgcgt   Gactcttccc   Cggatacaat   Gtaataaccc   1920     Gaaaacagat   Gcagtcagga   Atgcatggat   Ttccttcagg   Aagcacccag   Atgcttgaaa   1980     Ctggcgcacg   Cggtagcgca   2000       <210>   45   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   NKAPL     <400>   45   Taaatgatct   Tgcataaaac   Gtttatcatt   Tctgagagtg   Agatctaatg   Tgtatcgaga   60     Aagtggtttc   Caaactacaa   Agtttctgaa   Gaagtctccc   Tagatagaaa   Gacatctgtc   120     Tacaagatcg   Agtgggatgc   Ttctgtgtgt   Ttctagggtg   Gaaaagtctg   Tgaatttaat   180     Aattaaaatc   Atgactctgg   Gccgggcatg   Gtggctcaca   Cctgtaattc   Cagcactttg   240     Taaggctgag   Gtgggaggat   Cgcttgaacc   Caggagtttg   Agacagact   Cagaaacaaa   300     Gtgacaacgg   Tctctacaaa   Taattattaa   Aaaaatcaac   Ctggcgtggt   Ggtgggcacc   360     Tgcagtccca   Gctcctcggg   Agtagctct   Gaacctagga   Agtcaagtcg   Gccctgagcc   420     Atgatcgtgc   Cactgcaccc   Caacctgggc   Gacagagtga   Gatcctgtct   Ccaaaaaaaa   480     Aaaaaaaaag   Tacgactttg   Gccttcacct   Agcttagagg   Gtgagctcaa   Actgattcca   540     Aaagaagttt   Tggttcttgc   Ttccagtggt   Aacaaggggg   Gttgggaagt   Gattaattaa   600     Acatatttcc   Tccacgaaga   Gggtggacaa   Gttccttttt   Taggaaggaa   Aaaaggagga   660     Gcgttggtag   Tagggatctt   Ccacagaggg   Gtaaagttaa   Ggaggtggaa   Atgaaaggga   720     Agaacaaagg   Gtgagaagca   Aaatggtaaa   Agcgaaatcg   Aaaaagagaa   Gtgggtgttc   780     Caacagtaga   Ggggatcatt   Gacgcaaatt   Cgtcctttta   Tgttcccaca   Cggctcaagt   840     Tggggaatat   Aagtcctaaa   Aacaggcgca   Ccctaatcct   Acctacttcc   Cacaagaagc   900     Cttcacgcag   Ccaaggcccg   Ccccacatag   Cacacgcgcg   Gattcgtttt   Ccgtttggta   960     Actgacagga   Agcggaagcc   Gtgcgtggga   Ggccgattct   Agtgcgcctg   Cgtggccgcg   1020     Aatcaccagc   Cagcctctgg   Gtctgtagca   Accgcccagc   Gttgaggcgc   Ggctcatgcc   1080     Cccagtatcc   Cggtccagct   Attccgagga   Catcgtgggc   Tctcggagaa   Ggcgacgcag   1140     Ctcctcgggg   Agcccaccat   Ccccgcagag   Cagatgttcc   Tcttgggatg   Gctgttcccg   1200     Ctctcactcc   Cgcggccgtg   Agggcctcag   Gcctccttgg   Agtgagttgg   Acgtgggcgc   1260     Tctttacccc   Tttagtcgct   Ctgggtcgcg   Agggcggctc   Ccaagattcc   Gcaactacgc   1320     Cttcgcgtcc   Tcctggtcga   Cctcgtatag   Tggatatcgc   Taccatcgtc   Actgctatgc   1380     Agaagaacgg   Cagtcagcgg   Aagactacga   Gaaggaagag   Agccatcggc   Agaggaggct   1440     Gaaggagaga   Gagaggattg   Gggaattggg   Agcgcctgaa   Gtgtgggggc   Cgtctccaaa   1500     Gttccctcag   Ctagattctg   Acgaacatac   Cccagttgag   Gatgaagaag   Aggtaacgca   1560     Tcagaaaagc   Agcagttcag   Attccaactc   Ggaagaacat   Aggaaaaaga   Agaccagtcg   1620     Ttcaagaaac   Aagaaaaaaa   Gaaagaataa   Gtcgtctaaa   Gagaagcata   Ggaaatattc   1680     Tgatagtgac   Agtaactcag   Agtctgacac   Aaattctgac   Tctgatgatg   Ataaaaagag   1740     Agttaaagcc   Aagaagaaaa   Agaagaaaaa   Gaaacacaaa   Acaaagaaaa   Agaagaataa   1800     Gaaaaccaaa   Aaagaatcca   Gtgactcaag   Ctgtaaagac   Tcagaagagg   Acttgtcaga   1860     Agctacctgg   Atggagcagc   Caaatgtggc   Agatactatg   Gatttaatag   Ggccagaagc   1920     Acctataata   Catacctctc   Aagatgaaaa   Acctttgaag   Tatggccatg   Ctttgcttcc   1980     Cggtgaaggt   Gcagctatgg   2000       <210>   46   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   NR5A2     <400>   46   Ttcttcgatg   Tcgggtcccc   Gaggtaggca   Cggagtccct   Ctgaaagcag   Ttgcctatct   60     Gtgccccttt   Ggtgtaaagt   Tagagtttac   Tttgttgggg   Gaaggggagg   Tagaaaagat   120     Cacagttggg   Aaagtgcgct   Tttcgccttg   Ttcctaaaac   Atgcctcaag   Actgtcatcg   180     Cgattgttag   Gagagctatc   Aacgtctagg   Ggctataaag   Gaatttctga   Accctcggcc   240     Cttcccaaac   Ccccaggttc   Ctaaaaccct   Agtgggggt   Tcttggggct   Gggattcagg   300     Ctggcaccgc   Tgggaggacc   Tcgcctagca   Tccctttatt   Aatatttcac   Gaaggcaggc   360     Tcctgccttc   Tctggagcct   Cttttctcgg   Aatgttccca   Aactctggct   Aactcactcc   420     Cctgtgagcc   Atcctagggc   Tctgtggccc   Gggaagagac   Gcgtcaactc   Cgcgggtctg   480     Cgcgcagtcc   Ttagccgcaa   Agtgctgcaa   Gtgacccccc   Tgacggccct   Ttccgaccga   540     Agagctcggg   Aaccaaagag   Aaaaaaaata   Actttatttt   Caaaagaaca   Agtcatcact   600     Gcggcgatac   Tgtggcggag   Gactttggcg   Atggggtggg   Ggctatttct   Ctttcctttt   660     Tggtaaacaa   Atcagaggaa   Acttctgccc   Ggccgtggct   Ttccatcccc   Cacctgcccc   720     Accccctgca   Aacgccactg   Attacttaa   Aacaaactcg   Gctgcgtgtt   Tgtgcgccgt   780     Tgggtagcag   Gaggtagagc   Ctaggcgaga   Gcctggtgcg   Cccacgggtt   Tcgccgaaga   840     Gtgcccgggg   Gagtgcgggc   Agggtcccgg   Ctgcgcagac   Ctgcgggtgc   Ccgcccaccc   900     Gcgccccgcg   Ctcccatact   Tgacctgtgt   Ggatgtggag   Tctccgggaa   Ataccggatc   960     Aggcacttcc   Tggggtctcc   Tggtcactgc   Ccttcctgtg   Catagtttgt   Catcttttta   1020     Gctgcgaaga   Cgccttcgtg   Ggtctgcgtc   Cggagcaagg   Cggttacccg   Atcccggcag   1080     Tgagccgcgc   Cgcgcgtcgt   Ggcggcctga   Tttctgttta   Actttaatag   Ggcgatctcg   1140     Aggtgtttat   Attttgctat   Gatgatcgga   Aacatgtgag   Gttcattaca   Gggcttcaat   1200     Actttgaaac   Caaaaccctt   Ctgtgtgtct   Tttactcttc   Tggtattttt   Ccccgtacgg   1260     Gcgtcctcta   Ttttcttttt   Ccttcttttt   Attttcacag   Attttcaaac   Gtaaggagat   1320     Gaaagtatcc   Agaatagaaa   Agtactgtca   Atacggaact   Gaatgtttcg   Attattacac   1380     Agatctgaaa   Gttgggagcc   Tcaggctgtt   Tagttaaagt   Gggctgctgc   Tgagaagcgg   1440     Gtttctgggg   Cttcagtttc   Tctgtcggac   Agaggttgca   Aattggtgct   Gctgtccctg   1500     Taagcaaggt   Gcacttgcag   Caaaccactt   Caagagggag   Ggaataaagc   Ctgcgcttgt   1560     Ttctctacct   Taggcgaagg   Tgacattttg   Gaatttaact   Tcatagggat   Ttaaaagaaa   1620     Ttctaaactg   Tcaccttatg   Caattcatgt   Ctctatttgt   Tgctttgtgg   Agttatgaga   1680     Cttgtgttta   Aaagcggtca   Gtttaaaatg   Ttaacaaaag   Aagttggaat   Tgtttgtggc   1740     Acatggaatt   Atatgaggtc   Catgcttatt   Gatgacaaaa   Gatgttttac   Ttgtaaaaat   1800     Agttcagtaa   Gaccttgcta   Aaaattgttt   Tttattttata   Ttttaccatg   Tgatatttgc   1860     Ccagcaatca   Ccaaaatgct   Ttttgttgca   Ggattaacac   Ctacatgtaa   Attattgaa   1920     Tatgtgtata   Catttctctt   Tttgtttcag   Tgtctcaatt   Taaaatggtg   Aattactcct   1980     Atgatgaaga   Tctggaagag   2000       <210>   47   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   NRN1     <400>   47   Aggcttggcg   Ctctgtcctt   Ggtgggcgct   Cagcaaacac   Tgctgaatga   Atgaacgaat   60     Atagtccctg   Gaagccacca   Gcagttaccg   Aaatggattg   Tttcattata   Aaaccgattg   120     Cccaccgtgg   Actctgtatt   Ccgagtgaga   Ccctcggatg   Caccctctcc   Cgccccgctg   180     Gaaagagggc   Agcctggacg   Tcctgagacc   Tggcgcggat   Gatgagtggt   Ctggagagga   240     Gaaggccaga   Ggccgggcgg   Ggtcacggat   Gagtctgcct   Gggtcacctc   Cgcaaaggcc   300     Aaatccacga   Acctcgggcc   Tctttctctc   Ctcctcccct   Gtccgccact   Cggctcccca   360     Gacaccctta   Acaacccacc   Cgcccgccaa   Aaagcccgcc   Tacactccgg   Acggcagcgg   420     Ggagaggctg   Ttcttctcca   Ggtgccagcc   Ctgctgctga   Aagtgagctc   Gccgcggccc   480     Ggggctcctg   Gccccagctc   Aggactccct   Gcagagagca   Ggcagggata   Aaagctgagc   540     Ggcgggagga   Ggaggaggag   Gaggaaacac   Aggccgcacg   Aaggtccaag   Ccccaagccc   600     Ccaagccccc   Ggcctctgga   Cggccaaacc   Ccgaggcgcg   Ggactggaag   Gacaggtacc   660     Aggctgcggg   Cgcgcggctg   Tggccatctc   Tttccgccct   Gaggccgacg   Aacccggctg   720     Gaagctgagt   Gcctagcggc   Ccaaagcagc   Ccgggcgccg   Ggagggcgcc   Agagaagcac   780     Agcgttaggg   Cggggaagaa   Agggtgaatc   Tcagaatcga   Aatccgcact   Ggcgcccacg   840     Accctgggcg   Ccggcctggt   Cctcggcagc   Tttctggcgg   Ctgcgcttgt   Gtgtgaatgt   900     Gtcccgggag   Gaccggacac   Ctcaatcccc   Cggcccccaa   Cgcgggcgcc   Tgtccgcgag   960     Cgccgggcca   Gacgccgaag   Aggaaggtga   Ccgaacccgt   Agcagcttcc   Gagagcgtac   1020     Ccgtttgcaa   Attgctgcag   Gaagagcgag   Gcgggccttg   Cgctttttaa   Tccggaacgg   1080     Gaagcactgg   Ggaagggacc   Gaggttaact   Tcgacctccg   Ctggggcaga   Tacgtaaacc   1140     Ttctcaaacc   Tccgagttca   Ccttacagcg   Aacattaaat   Acccttgcga   Ctacaatact   1200     Aacaaatcga   Acactgacgt   Aaaatcttaa   Gaataaacga   Atctttgttc   Tgatagagct   1260     Cgttcaaaat   Ggaaatacac   Tccacacatc   Ttcctctata   Acgcatgtca   Caaatacagc   1320     Tttgcagaga   Agaaacgaaa   Taaaataaag   Tccaatctcc   Ccgtccacgt   Ctctccccac   1380     Cccttgccta   Cacccccaaa   Actcagtggc   Gaaagaagcc   Cctaaaatgc   Attgacattt   1440     Tttaagggga   Attggggctc   Gccgggggcg   Ggaggcctct   Tgtcacgtta   Tcttcccagg   1500     Cgctgctgga   Gaagaccctg   Cacaccgcgc   Atgtgtgagt   Gtgtgctgtg   Taaaataagt   1560     Cgtgaacatt   Tctgtctttt   Aaaactgtga   Ctccttggac   Tctagccttc   Tctgggaggc   1620     Cgggaggctg   Cgcgcgggac   Ggattttgca   Ggcgcacgcg   Tcccagcagg   Tcgcagcccg   1680     Tgggtccctc   Gctgtccttc   Ctgaaccccg   Cttaggcgag   Actctagcgg   Gtgaccctgg   1740     Ctccttccct   Gtcctctctg   Ccgtcccctt   Cttgtgcggt   Ttccatccgt   Tcattcattc   1800     Gttcgacctc   Tcattcattc   Cgaacttcct   Cctgctgcgt   Cttctttcgt   Gttcaccaca   1860     Ctcttctacc   Tccccgcccc   Tcccaacccc   Cacttttctt   Gccaaatgtc   Aatgatttgg   1920     Gacagctccc   Agccgtgaat   Taataaagac   Cgaggttctg   Ttgcaggaaa   Gggcagacat   1980     Tagggaacaa   Atacgttcaa   2000       <210>   48   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   OSBPL2     <400>   48   Cagccctgtt   Ctcgggtagt   Gagatgtgga   Agactggccc   Cttccctctc   Tcacctaacc   60     Cagctctgga   Gaggtctgtg   Ggcagatggg   Agagcattt   Gacttcagcc   Tcccctccgg   120     Tctgaactct   Gaccctacag   Caaaagtccc   Aggactgagc   Ctctttggct   Agaactgggt   180     Cacaggctga   Cccttaaacc   Aactgctgtg   Actatgtagc   Cagcctggtt   Tatgccactc   240     Cactcacctc   Aaaccagacc   Catgacttca   Atgagatgtt   Gacaggggaa   Ccctggtttg   300     Cagatgaaac   Tgagtgatca   Cageccaga   Gaggttaatt   Aatttgtcca   Aatccacaca   360     Gctggtaaag   Aatgcaagct   Ccaggtctga   Ttccagaact   Tctgggctta   Accctggagc   420     Cactgtaggt   Cagtgggagt   Ccaaagggtt   Ttaagtatgg   Tggtgaaacg   Gtcggggatg   480     Cagctggagg   Ggtaaattgg   Cgctggattt   Tggttggcgg   Tgaatggcat   Gcaaaggagg   540     Tggacgatat   Tcaggatttg   Gtaggacagt   Ggaagcagct   Acgccccagc   Tatcgcacgg   600     Tccccagcat   Ttgtaggaaa   Aagcccccag   Ggctttgggt   Agcctcgcag   Gcccgcactg   660     Ccgccaggac   Gcagtgcacc   Tgagggcgga   Gcacccacgc   Cccgggccac   Ctgactcact   720     Gtttgtcaac   Tctgctctct   Gcagccacgc   Cctttcctcc   Ttgcctccct   Ccccttttgg   780     Ctcaggggcg   Gcataacccc   Gcctctctcc   Tgctgtgact   Ggctgtcctt   Gccgtcactc   840     Cgctgcgtgg   Gcggggctct   Gagggggcac   Aggtagaggc   Ccttcgcgaa   Gggattagca   900     Tagtcccacc   Ccccggcgcg   Agcctcgggc   Cgggcgctga   Ttgggcaggc   Agcggccgac   960     Gcggcggcgc   Cgggcgcagc   Gagtggcggg   Cgcgggctgt   Cagtcggcga   Ggcggcgggc   1020     Cgcacttccg   Cctcggtgtc   Agtgggtcgc   Gggcctacgg   Ggcgggggcg   Gggcggcagt   1080     Gagctcggcc   Ggcaaccgag   Ggacccgcgt   Ccaggtgagt   Ggcccccgcc   Gccgccacgc   1140     Gaaggcccgg   Gaccccggcg   Agctgcgggg   Cctgggccgc   Gggctggggc   Tggagccggg   1200     Gcggggaggg   Gagggcgggc   Cgggcaggac   Ccgggtccgc   Aggccgcctc   Cagccccggc   1260     Cccggccccg   Gcctcgaccc   Ccactgggag   Gcgcgcccgg   Ctagagccgc   Agcctggcgc   1320     Cccggggaaa   Ctttgggagg   Aaagttccgg   Ccgggcgtgg   Ggcctgggcc   Tgggtcccgc   1380     Ggcccccgca   Cccttccccc   Tgcggtcgcc   Cggcaactgc   Gatcccggga   Cccccggccc   1440     Ggcccccccg   Agatccccag   Cccccctgct   Gccccgctga   Gcaggaagtg   Gggacgggcg   1500     Cacctgctcg   Cggcctcgcc   Ctctctcacc   Acctcaccgg   Gaacagggaa   Ggatttcgtg   1560     Cgcatttagg   Gcgatcctgt   Aggtgaggag   Ggcgagttcc   Gccgggaaga   Agggcaggga   1620     Gacgcagtcc   Cactccgacc   Ctggccttct   Tgtcccgcag   Gcctgtgtgc   Acgtcgtccc   1680     Ggggagggtg   Cccgcgagcc   Cttgtccgtt   Cccctgggct   Ctgtttttgt   Ttttaattta   1740     Taaatcttag   Cagactacac   Acggttgaga   Acttgctacc   Taaaacctat   Ctttggtaat   1800     Gtaattttaa   Gaggttcctt   Ctttcgccag   Tttattttg   Gtactcagaa   Gaatacgtct   1860     Ttagactttc   Caagtttata   Agcccagacc   Aagactgtta   Ggtcgtcaca   Gcacctcagc   1920     Ctccccgctt   Catgggagga   Ccggcgacga   Ggcagtgggt   Gtcggggtgt   Tgcaggctct   1980     Cctggggtga   Gggtcacctc   2000       <210>   49   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PARP15     <400>   49   Actttatatg   Tatctcaatg   Caaatacgat   Accaaaacct   Tttaccctgc   Tctctgcctt   60     Ggaggtggta   Ctgagggctg   Acctctaagt   Accacatcag   Ctccattctc   Tgattactca   120     Ttgggttctg   Cagtgggagg   Taccagcacg   Agattggaag   Gcacacggag   Agagtacttg   180     Ggatgcttat   Actcccctgg   Ctgtcttccg   Aaagcagtca   Tgggttctac   Ctgctggcac   240     Ttggtatagc   Tcttaccaag   Ttcaggagat   Gccccctccc   Ttgccccttc   Agcctagatg   300     Gtaaggggag   Gaggctactt   Caccatctct   Caatggtttc   Cttaaccctt   Tgcccacacc   360     Tgtgtaaata   Atttctttat   Taaattatct   Tcaattatta   Attttgagta   Taccatctgt   420     Atactgccag   Gacttttcgt   Gatacaccag   Gtaacagtat   Taatctatgt   Tttatttctc   480     Cacctcctac   Ttcacccctc   Actccaaaga   Gaggggatct   Gtgtctaatt   Catctttata   540     Atcttaacac   Agtgccaggc   Atatcaaagg   Ccttcaatac   Gcgttgattg   Aattaaataa   600     Tgccctgttg   Ggccagaggg   Gaacctgact   Ccagccctgg   Cttagggagc   Acaggagaga   660     Acccagtgta   Tttttctaaa   Tatgggtgtg   Tagggagaat   Tggggggaaa   Ggagtgggat   720     Gcccaacaga   Aaaggaaagg   Aatactgatt   Cctgtgtttt   Aatgtgccag   Gcattctaca   780     Gactttatct   Catttaatct   Tcattataat   Aacatgaaat   Agttatggct   Gtgcccactg   840     Tacagatgct   Attgactgag   Gctacataac   Taataaaatt   Gcagacctca   Ggattttgac   900     Ccaggatttg   Tctggcagta   Acgtctgtcc   Caaagggcga   Cacaatcctg   Aggcagctgt   960     Tcgcaaactc   Gaggcctcaa   Tctttgacgg   Aagcggtttt   Cagagaaaag   Aagttcgagg   1020     Cacaagcctg   Ttgggtgggg   Cgcaactgca   Gtcccagcga   Gctgaggatg   Gctgcgccag   1080     Gcccccttcc   Tgccgctgct   Ctgagtccag   Gggctccgac   Ccccagagaa   Cttatgcacg   1140     Gagttgcagg   Tgttacttcc   Agagccggac   Gagatcggga   Ggcggggagc   Gtgctgccgg   1200     Ccgggaaccg   Tggggcgcgg   Aaggcctccc   Ggcgctcttc   Ctcccggagt   Atggtgagga   1260     Gcgcggggga   Cgggtgcggg   Aaggggacag   Cagggctgag   Cctggggccc   Gcaagaccca   1320     Gcagcccgag   Cgggcgcaga   Gaccccacgc   Cacgcacaac   Cctctcttct   Agggggcgcc   1380     Gactacactg   Acttccctgt   Tccggaagag   Ggggatgcgt   Gctgcttctt   Tttccttagc   1440     Atttctggtg   Gttttttttt   Tttttccctt   Aaaatttaaa   Agttctttat   Aaagtttgaa   1500     Agtagatgag   Tcctttattc   Gtgatatgtg   Tttagaatat   Gtcctcccaa   Tttatttttt   1560     Gttttttgag   Tttgcttatg   Gggggctttt   Gtttctcttt   Gccatgcaaa   Tattttaaat   1620     Tttgtgtggc   Aagacttacc   Agtcttttat   Tttatgacgt   Ctagactttt   Agtcatattt   1680     Taatatatga   Cttttagtca   Tactcttccc   Taaccccaag   Ttatagaaga   Gttcactcat   1740     Gcttgcttct   Agtacttgaa   Ctgatgtatt   Ttttacattt   Agatctataa   Tacatttgga   1800     Gtgtgttatt   Gtgtgtggtt   Tgaggagtga   Atctaattat   Tttttttcaa   Atgggtatca   1860     Agtgtcccaa   Caccatttat   Tataaaggtc   Gtcactgtcc   Cagtaacttg   Agataccagc   1920     Tttatcatgt   Actagacttt   Catatgtggt   Tcgggtattt   Ctggaccttc   Tattttcatc   1980     Cattgacccg   Tttattcatc   2000       <210>   50   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PAX6     <400>   50   Tagtctaagt   Ttgggtcgtc   Ccttccctga   Ctcactaagg   Ggacacttcc   Gggccccggc   60     Tctggccctc   Caagggccgc   Agggtggtgg   Gcgcttctct   Ttcccgggct   Tggcggcccg   120     Gctcccatgg   Cgcccgcgcg   Cttcccgccg   Aggcagccag   Cgcagcgccc   Gcagtaaccg   180     Gagcccgcgt   Tctagctcag   Tgagaatcgc   Taattattag   Gtcttccgaa   Gtgaagctca   240     Aatcacacgc   Tgggagcttt   Acgcgctgcc   Cagctctgtc   Ggccgcattc   Tttcgtactc   300     Cgcgtctttc   Tgagaaacga   Accccatctc   Tagactttgt   Tgcggtccag   Ccatctgcac   360     Tttgcaaccg   Cgggaaactt   Ctgctgcacc   Tcgcccgacc   Cgcggcaggg   Tgtctttaag   420     Cgctccaggc   Gcgggtacgg   Actttcccaa   Gcgtggatgt   Cgtgaactgc   Gatgcagagg   480     Aggtctggat   Gcaaagtgcg   Tccccacctc   Ctgcattttt   Cgcggtcgcg   Agtggcttta   540     Gcagacagca   Gcagcagact   Cccgccccct   Actcccagct   Cagggccgga   Ctggaagtcc   600     Actcttagga   Gtggaacatt   Ttgctacttt   Tgcagaagag   Cacactcggc   Aaagacaagt   660     Ccctcctcca   Ccccccttcc   Tatccctccc   Tcagtaactc   Gcttccatct   Ttgtatgcct   720     Ccttttaaaa   Gcaaaaatca   Agccccggg   Ccacttgggg   Cgggctttga   Tttggggaca   780     Gcagtcgctg   Gcagcggaga   Ggccccgcgg   Gccccgagcc   Gggccggggc   Cggagcccgg   840     Gcggttacct   Gggagcggag   Ggcggggagg   Caggtgagcc   Tggcagcgcc   Ggttcccaca   900     Cttctcaccg   Ccgctcggca   Ggggaagtgg   Cagatctgac   Agccgcgttc   Tacgcgagga   960     Cctgccccag   Agtttaaatg   Tcaatgataa   Gaaaagaggg   Tgctcaggca   Ggcgctaact   1020     Ttccttaata   Tccacgccag   Cgccgtcctc   Attggctgcc   Cggcccgcgt   Gacgtcatgg   1080     Cggctagagt   Tgggcacagc   Tctgcgccga   Ctagttttcc   Ggccgggcgg   Gaggctgctt   1140     Ctccccaccc   Agggtccggc   Cggctccaac   Ccctgctttg   Gccttccttg   Gcccggcctg   1200     Tgactgctct   Agcccggccc   Ggtccagcct   Gggccgccgt   Cctgtatggc   Gtagagtcga   1260     Tccccaggaa   Actagtcttg   Ccgagtgcgc   Tcctccgcac   Cttcgggcac   Tagggcccca   1320     Agatctctgc   Ccttaggctg   Gccagctacc   Tctctgggta   Atcaccctgt   Cccctcctcc   1380     Gatccccaag   Ggagtccctt   Catcggagag   Acccgaaggc   Cgcgccggga   Tggagaggcg   1440     Cttttggcag   Gaatcatttt   Taggaggagt   Tcgaggctcg   Atgagtaccc   Tcaacctggc   1500     Cctcgagccc   Gcaagtcact   Agctgggcac   Agacgggggc   Tccgggaaga   Ggacatgcga   1560     Cccctttttc   Agggcctagg   Ccaaaggtct   Ctccaggcct   Gctgggttct   Caagagggaa   1620     Gccctaaagg   Gggcctaccc   Gggcttccct   Cgccctctgg   Ctgaaaggct   Ccaaccacat   1680     Tagaaaatgt   Aggtgattgt   Atttatcttt   Gactttgaat   Taactgttga   Ctttgtgact   1740     Tagaggagga   Aaacaggaaa   Atcccagatt   Ctgaagtcaa   Tactcataga   Aattggggcg   1800     Gggtctgcag   Gacactgact   Tgctggtctg   Tgcctgtttt   Tccctcacac   Cttctgtgga   1860     Ctgcgagatg   Gcttagcgga   Gctaggcctg   Gctatcttgg   Aatggagatt   Tagaccctcg   1920     Ttgtcattcc   Cgtccctcat   Ccctcaaaac   Aggaagcttc   Tcaactcctt   Cccctatgct   1980     Tccatctggc   Tctccaattt   2000       <210>   51   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PCDH17     <400>   51   Gtaaaagtgc   Tgctagattc   Agcttcacct   Tcttccctcc   Atccttttct   Cttgcatttt   60     Ctttttcccc   Aaaaacatga   Atctggtttt   Tctttctata   Gactgagtca   Gagaaagcgt   120     Taggaagaag   Ccgcaactaa   Tgtctgtgaa   Gggaggacca   Tgaggcgaga   Gtgaatacga   180     Ttcgttccgc   Tgcttctgac   Tcatccggca   Gatcggaaca   Cctgcatttc   Tggatgtgtc   240     Attcccgtat   Gtcgaggcgc   Ctccagaacc   Cgaaataatg   Tgtagacaga   Cctgtgtcta   300     Acatcccctc   Ggagggagct   Cccgggggta   Ggagcccctg   Gctggaccgc   Cgcggccgca   360     Gctctgcacc   Ccctgccctc   Cctgagtcgc   Ccagaaaaac   Tgaaagagag   Actgcagaat   420     Gcatcacgcc   Aaaccttgat   Gtgttgcttt   Catccagccc   Actcctccta   Ctataagaga   480     Aaattgaagg   Aaaaaaaaaa   Acacgtactt   Tatttgcttc   Aaatattcat   Cacttttatt   540     Cctcgccaag   Gttttctttt   Ctagatgaag   Aggactggga   Ggcagggcta   Ttggaaggag   600     Atgctgaata   Gaaagaaaag   Aggcacttga   Cagcccagcc   Ctgtgaatgc   Agagactgtt   660     Tcccttctag   Cgagagacag   Ggagagtgtg   Tgtgcaagga   Ctgggaggga   Ggctccccct   720     Tcctttttat   Tcggcctccc   Ccctcctcct   Ttaaatgtgc   Acgtccaacc   Atgagttgcc   780     Tgttgatttc   Ccttcgcctg   Ggaagaaaag   Caaactggaa   Ttaaactgct   Tggagagaag   840     Tccttgctcg   Cggggagagg   Atgggatggt   Agcggaggct   Actggcttgg   Cgtagagaaa   900     Tcagagagtg   Tgttctacga   Acagaggcga   Agatttatct   Ctctacttcc   Cccctcccaa   960     Tagactcaca   Cagcaaatgc   Tgatcaggct   Gtggctttct   Tgatttcggg   Ggagagcctt   1020     Ttccgaggaa   Gagagggagg   Agcctggtgg   Ggagaggaaa   Ctacaaatcg   Ggacactagt   1080     Tctttacgct   Gcatttcctc   Ccctcccttt   Ggctgctcgg   Aaaggagaga   Gaggaaaaaa   1140     Aaaatacgct   Tggctggtag   Atgcagtccg   Ccgccgccgc   Tgcctcagcc   Agcaatgcaa   1200     Gattagatct   Ctaaatgcag   Caaaacactg   Cctgaaaaca   Gaccggcccg   Cgcagcaagc   1260     Agacatttca   Cggtgcgctg   Gggaagcttc   Aaaatatatc   Tgtgactctg   Tcttcgttgc   1320     Tcttcatccc   Catcaatttc   Atcacgggag   Gcgagcagca   Agtaagaatt   Tcactttcgg   1380     Atctgcctag   Agacacacct   Ccctgctccc   Tcccccactc   Gatgtgaaga   Gttatccgga   1440     Gtctccgggc   Gggagtagat   Ttgcagcacc   Ctagcgggag   Cgaggaaaac   Ctactgattc   1500     Tttagctcat   Tatcatctct   Cccagacgag   Atttccttct   Tatcgcctgc   Ctcatcgctc   1560     Aagtttgagc   Ctcccgaagt   Ccgggcggga   Gagacgaaac   Ccctggctca   Cccccagccg   1620     Caggaagcca   Ccgccttgct   Ccaagcccct   Gcagctctgc   Tgcaccgcag   Cttctcaccc   1680     Agtgcggatg   Ctgtagatca   Acaggttcag   Ggaacttgag   Cagaataagg   Agagaccacc   1740     Gggtgccgca   Gctcgggtgc   Agagggaaaa   Aaggacccat   Agacttgtgg   Ctcgcgtcgc   1800     Gcgcgcacgc   Tgcgccaggg   Ccccaggctg   Gcgcgcactc   Cctctctggc   Tcctccagtc   1860     Cgattgctcc   Tgcccccacc   Ttacaggtct   Gggatgtacc   Tttccatctg   Ttgctgcttt   1920     Cttctatggg   Cccctgccct   Cactctcaag   Aacctcaact   Actccgtgcc   Ggaggagcaa   1980     Ggggccggca   Cggtgatcgg   2000       <210>   52   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PCDHGA11     <400>   52   Ctcctcgcgg   Tgattctagc   Tattgctcta   Cgcctgcgac   Agtctttcag   Ccctactgca   60     Ggagactgct   Ttgagtcagt   Tctctgctcc   Aagtccggac   Ctgtgggtcc   Ccccaactac   120     Agtgagggaa   Cgttgcccta   Tgcctataat   Ttttgtgtgc   Ctggggatca   Aatgaatcca   180     Gaatttaatt   Ttttcacatc   Tgttgatcat   Tgtccagcca   Cacaagataa   Cctcaacaaa   240     Galagcatgc   Tactggctag   Cattttaact   Cccagcgttg   Aagcagataa   Gaagattctt   300     Aaacaggtaa   Gtatttaaaa   Atgtatttaa   Tcctttttat   Attacaatat   Gccaatatat   360     Tccaatatag   Tggtattatt   Ttaagattct   Agataacttc   Ttcatagagt   Tcgcaaaata   420     Taggtcaaat   Tttaggttat   Cattattaaa   Acaaaagttt   Aaattaaatg   Cctcagtctt   480     Cctactattc   Aaagacattt   Taaagcaaac   Tacatgggta   Atctccggtg   Acatttttat   540     Gaagtaaaat   Acctttcggt   Taaaaatata   Aaatacaggt   Atatttttac   Ggcatggtat   600     Tttaattgaa   Accctgatgc   Tactcaattt   Ttctcaagta   Tttcatcttc   Atttactcaa   660     Taaaggaacc   Ttgtaagaat   Tatagttagg   Catcctacct   Gatgatttta   Tcgggaccgt   720     Attatttcca   Cttccagaaa   Tgtcgttcct   Ttcagtcggt   Taaaatcaat   Tggaaccaac   780     Tacaacctac   Aagttttcag   Ctccagtaat   Attttgaaaa   Ctttttaaaa   Attatagaag   840     Cccttttaat   Aattactcct   Ttcgcaggtg   Ttcttggtaa   Agttttaacg   Tcacataatg   900     Taagtattgt   Gtatcatcgt   Ttttaagctc   Tacaaatacg   Tgtgattcac   Aaaggtgagc   960     Gtaatcattt   Cttctggaat   Ttcttagtcg   Ttgcaataat   Aagaatgggc   Tctaggcgcc   1020     Gctgctcacc   Aatcagggaa   Tgggaagctg   Cgcgccattg   Agtccctccc   Tcccccgcct   1080     Ctaccacaca   Aagcggaatg   Agatggatac   Tcacagatcc   Tgacactgga   Gacttagaag   1140     Tattttcctt   Cgctttctga   Tatattttgg   Atgtagtcgg   Ctagagactt   Catagataca   1200     Taagccgatt   Cacaaccaac   Cagctcgaga   Aaccgcggaa   Tatcggctta   Gagcctgcca   1260     Tggcgaatcg   Gctacagcgc   Ggggaccgca   Gtcggctgct   Gctgctgctg   Tgcattttcc   1320     Tggggacgct   Gcgggggttc   Cgggccaggc   Agatccgata   Ttcggtgcca   Gaagagaccg   1380     Aaaagggctc   Cttcgtgggc   Aatatctcca   Aggaccgtggg   Gctggagccc   Cgggagctgg   1440     Cgaagcgcgg   Agtccgcatc   Gtctccagag   Ggaagacaca   Gcttttcgct   Gtgaatccgc   1500     Gaagcggcag   Cttgatcacg   Gcaggcagga   Tagaccggga   Ggagctctgt   Gagacggtgt   1560     Cctcctgttt   Tttaaatatg   Gaacttctcg   Tggaagacac   Cttgaagatt   Tacggagtgg   1620     Aggtggaaat   Aatagatatt   Aatgataacg   Cccccagctt   Ccaggaggac   Gaagtggaga   1680     Taaaagtcag   Tgagcacgca   Attcctgggg   Cgcgatttgc   Tcttcctaat   Gctagggatc   1740     Cagatgtggg   Cgtgaactcc   Ctccagagct   Accagctcag   Ccctaataat   Tacttttcct   1800     Tgcaactgcg   Gggcagaacg   Gatggggcca   Agaatccaga   Gctagtactg   Gagggaagcc   1860     Tggaccgaga   Gaaagaggct   Gctcacctgc   Tcctcctcac   Agctttagat   Ggaggcgatc   1920     Ccatccgaaa   Gggcgcagtt   Cccattcgtg   Tggtggtcct   Cgatgtaaat   Gatcacatcc   1980     Caatgtttac   Acagtccgta   2000       <210>   53   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>, PFN3     <400>   53   Cctgtgagcc   Ccagaactgc   Tttacaagcc   Accaagccca   Tcctgtcacc   Cactcacaac   60     Ttgctagtgc   Ttgaggtatg   Agtggagggg   Ggaggagcaa   Attggcctcc   Agcctgacac   120     Cctgatgggg   Agaggtgttc   Gcgggatggg   Gagggggctc   Cctttacttg   Tcctgcctaa   180     Tgtgtgggaa   Tatctctgag   Aaaggacgct   Aaggctgaaa   Cagectttga   Gaagccccca   240     Cccttggact   Cttcctcagc   Tgcggagtcc   Ctaggaccct   Gggaacgcgc   Caaggagcag   300     Cagtcaggcc   Aggaggctct   Gcaaggcgtc   Catgggagag   Cagggtgtag   Ggcacagggg   360     Cctggcagcc   Tctagactca   Aaatcccggc   Tccaccaggt   Aaccgtcttg   Caaagaccag   420     Tttccttatt   Tacaactccc   Cccaccgcgc   Aagtggagga   Ggagccagcc   Gcgcccaggt   480     Cacagtttat   Ttggcccgcg   Ctaccagtgg   Gcggcctggc   Tggccggcta   Ggcgccctgc   540     Atgcgcagcc   Cgcgtatgag   Ttcgtgcacc   Gtcttgttga   Ggatgccccc   Atgtacgccg   600     Cgtcggccca   Ttagcaccag   Gagcgcgcgc   Ggcgcacggc   Ccacccacac   Ggcgcgcgcg   660     Tccagcccct   Tggtgcgtgc   Gtccagcacg   Ccgtcaccct   Cggccagcag   Gtggtcgcgg   720     Atgacgcagc   Agcggcggcc   Ccccaccctct   Aggcccgcct   Gcaggaaggt   Gtgcctgtcc   780     Ggccccgtga   Gcacgcccac   Ctcctgcggc   Gagatggccg   Ccagcaggcc   Cccgggccgc   840     Gaagcccaca   Cgcagctgtt   Gtccgcatgg   Cccacgatgg   Ccacgtcgtc   Gatgcgctgg   900     Tcccgcagca   Ctgcactgat   Gtagaccttc   Cagtcgccca   Tcgcgctccg   Agtgcgccca   960     Gccgcctcgc   Acctctcggg   Gaaatataga   Ggcgccacgc   Ggggaaggcc   Tgcggcgctg   1020     Tgaggcaggc   Tgggcggggc   Tgtgacgtca   Cacaaggcgc   Cgtcccggag   Cgaccaccca   1080     Ggctggggca   Cgtggggcgt   Gggcgtttag   Tgctgtcgca   Gttctaaggt   Tatcctgtag   1140     Gatgggtttg   Gcagagcgca   Gcggctcact   Cctgtaatcc   Cagcgctttg   Ggaggccgag   1200     Gcgggcggat   Cgcttgaact   Cagtagcgag   Attatataa   Actattatag   Gatcgtgtcg   1260     Ctgcacgcca   Gcctgagcca   Cagagcgagg   Ccccgtctct   Aaaaaagcaa   Aaacaaattt   1320     Taattaaaaa   Aaattttttt   Gagatgaggt   Ctcactatgt   Tgcccaggcg   Ggtcaggaag   1380     Tcttgagctc   Aaacaatcct   Cccgcctcag   Cctctcaaag   Tgacgagatt   Acaggcgtga   1440     Accaccgcat   Ctggccaatc   Tatttttaat   Tttaaaaagc   Tggttttgtg   Aaaaaaggat   1500     Gttgtgtctg   Gacagccaga   Ccttcacttg   Taagggaacc   Aaccattcaa   Cccccagatt   1560     Gtggttctta   Agcatgagag   Aacatcagaa   Tcccccgcaa   Ggctgttaaa   Cagattgctg   1620     Ggccccaccc   Cagectttct   Gttcagcagt   Ataaagtgta   Gcccgagaat   Ttgttatgtg   1680     Taacaagttc   Cctggtgatg   Gtactgctag   Ccaagggact   Ctcagaccca   Ctacactagt   1740     Gcgtgttggg   Gtggggacaa   Cgatatgtca   Cccagccctt   Agggtccacg   Ccacagtcaa   1800     Tgctcttttt   Ttctattttc   Ttttttcttt   Tctttctgtc   Tctctctttc   Cctccctctg   1860     Ttccttcctt   Ccttccttcc   Tgccggttca   Agtgattctc   Ctgcctcagc   Ctcctgagta   1920     Gctgggacta   Caggcgcacg   Ccgccgtgcc   Cggctaattt   Cttgtatttt   Agtagagacg   1980     Gggtttcatc   Gtgttgccca   2000       <210>   54   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PHOX2A     <400>   54   Tgggggaatg   Gggaaataca   Agtggcttaa   Aaacccgggc   Ccctttattg   Cgggctacgg   60     Gatctggttt   Tggtggctac   Gaagaggttac   Ggtcccaggc   Agcgtgggtc   Caagacaggg   120     Caggaggggc   Ctgatggcca   Cgcgagctct   Aggaagcttc   Ccgtctgggc   Agctcagctg   180     Cctggagagg   Tccttgctgg   Gggtcatgca   Tctcgtgggg   Cagcggtgat   Ggggtggggt   240     Gataagtggt   Gatagggctg   Ggctgggagc   Ctttttcaaa   Gatccagcgc   Ttgtagaggt   300     Ttgtggtca   Gtctttgcag   Gtggtgaggg   Gaaggcctgg   Taaggggccc   Agagctggat   360     Ggggatatat   Ttccttgacc   Tgaagggcac   Gagacagaga   Tttggcaacg   Gaagaaagga   420     Acaggagaga   Tgagagggtg   Aggctcattc   Ctgcggagga   Gaacctcgta   Ttctgggggt   480     Ctctcggggc   Attggagggt   Ctggccaagg   Caggaatggg   Ggcggctgag   Ggggacagtc   540     Gcattcactt   Ggcgagcggg   Cccagggatt   Ctgcaggaat   Tggagggagg   Gttgggccgg   600     Ggctgcgctc   Acctgccgag   Tagggcgcgg   Gctggtggtc   Gcgtagggcg   Ccaagtgcgc   660     Agttggagga   Gccgagcgcg   Gggcagggcg   Gccctgccgc   Ggggaaagcg   Ggccgcaggg   720     Ggctgtattg   Gaagccgccg   Ggctggctgc   Aggcgccaaa   Gtcgccgtag   Gcggacgcct   780     Ccatggccgc   Cacgcacgag   Tcgtacgaat   Tgaggtagga   Gtagtccatc   Ggcccggggg   840     Gcgggggcgg   Gggccgggcc   Aggccgggtc   Ggggtcgggg   Tccgggtgga   Ggtcggaagg   900     Gaggttcgag   Cgccaggctc   Cgaggacccg   Aggccagctc   Tgagcgcccg   Agagcccccc   960     Cgccccgtcg   Cggccgcact   Cagcccgggt   Gcaacgcaag   Tgcagccagc   Ccggcccgcg   1020     Cgccttttaa   Cgcgcaggac   Cccgcggagg   Ggggcggggc   Ggggcgagct   Ccgaaggggc   1080     Ggggcctagg   Aggcccagac   Accgcccaaa   Gccgccccga   Cccccacccc   Gaagggtccc   1140     Cgccgccgtc   Ttagggctca   Gaggtgtgga   Gctgggatgc   Gcgggaccct   Atccccggag   1200     Tccctatcct   Gccccaatcc   Ggaccagacc   Ttcggtctct   Acacagcgtc   Cgaggccaga   1260     Gggtcccgac   Ccttttcccg   Ggcctcccca   Cctgcggccc   Cgcggaaggg   Aggggaggca   1320     Ggcctggcgg   Cgctcgtgtg   Aagaagttaa   Ttcaattcgc   Tctgataacc   Gagtttatcc   1380     Gatctggccc   Ctcagccccg   Cccccagcga   Ggtcccatcc   Cggcggagac   Tgcggaggcg   1440     Gcccaggaag   Ggggtaggag   Accgggaaga   Gagggaggct   Gggatgggga   Cagggaaggg   1500     Acgtggatag   Acagaggaaa   Cagagaccgg   Gagagaaagg   Ggcagaaaca   Gtgatggaga   1560     Cagggacaag   Agatacaggt   Acacagaggg   Agacaaggac   Ggaacataca   Cagcgaaaga   1620     Caggatggag   Cggggacagg   Gcagagacag   Gagatgaggg   Taagagagag   Acaggatgga   1680     Gcggggacag   Ggcagagaca   Ggagatgagg   Ttaagagaga   Gacaagagga   Gacagggaga   1740     Cagggggacg   Gagaagagag   Tgagggaggc   Atggagacag   Aaggggtcgg   Gatgagacat   1800     Ggacggcaac   Caggactgcg   Gtggagagca   Agggagggat   Gagacaaaac   Agaggcagga   1860     Atcgtgagac   Agacacatat   Gcccagggac   Agtctgagag   Agacaggcc   Agggacagcc   1920     Acaagcgcgg   Gagcagaggc   Tgagagcgga   Gagaaaacgc   Ctccggggag   Cttagacacg   1980     Agggctggag   Cgcagagggg   2000       <210>   55   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PIP4K2A     <400>   55   Tgccaaaaag   Ccgacttgtg   Cccagtaata   Ttgcctttaa   Aggaaaaaga   Aaggacctaa   60     Gcactaaagc   Tgctgcccca   Aatctgctcg   Cgctccggta   Tcctcgcccc   Agtgccccag   120     Tgggaggctc   Gcacgcgccc   Agcccgggac   Aggtacacct   Gcccgcaagc   Ggaagacgcg   180     Ggcgccgcgc   Ggcccccaca   Ccgggtagcg   Gtcgcccgga   Cccggccccc   Agcagctccc   240     Gccggggctg   Acagccgagg   Cgccgtgccc   Cgcacaaact   Tcctacctcc   Caggctgcgg   300     Ggaccgacct   Gcgggcgggc   Gggcggaccg   Ggggcggcac   Tggcacccac   Cgtgagactc   360     Acatgcacac   Gggacccccg   Acccgcaccg   Ggccatagat   Ctaaagggga   Cgcaagtggt   420     Ggtgcctggg   Cggcccagag   Ggctgggggc   Acgcgccgcg   Gggctggggg   Cttcgaggcg   480     Ggcgagcagc   Cggaggtcca   Gggctgactc   Cggctccccg   Ccccgcagca   Gctgcagccg   540     Gaggaggagg   Ggaacgagga   Ggaagaggag   Gaggaggaag   Gggaccgcgc   Gccgcagctg   600     Agcccttacc   Gagtggttta   Ccccccacat   Gaggacgctg   Agcagcgggt   Cgctggcccg   660     Aaacagcttc   Actttctgcg   Ctacgaagtg   Cttcttcttg   Gtcttggtct   Tgctcgccag   720     Gacagaggac   Cctaggttgc   Cgggggtcgc   Catggccgcc   Tcctatgtcc   Cctccaccgc   780     Cgtgctcccg   Aggccgggga   Cccgccctct   Ctacaccccg   Gcccggggag   Gcagccgcat   840     Ccccccggcg   Gcggccccgg   Cgcgccgcgc   Tccgctccgc   Ccgccgccgc   Cggcgcgctc   900     Agccccactc   Ggctcgctcc   Gcccgctcgg   Cccggcagac   Tgcgctcggc   Tcgcgccccg   960     Gcccgtatcc   Tgcgcccgcc   Gcggatccgc   Gctcagcccg   Cggctggacc   Cggcgcgcgg   1020     Cgagcggctt   Ccgcgttggg   Cgccggcgtc   Atgacgcagg   Gggcgggcgg   Gcaggcggga   1080     Ggcggctgcg   Gcgccgcggg   Cggggcactg   Ggtgcggggc   Gcggggcgcg   Gcagctggac   1140     Cgttaggctg   Cgccttcccg   Ccccggctcc   Gctgcagccg   Ggccgccccc   Tgtgcgcggg   1200     Cgacctccgg   Gcgttcgctc   Cctgcccgcg   Gaggaggccg   Tgggttgcga   Gcgggagcct   1260     Ggggaccccg   Gctaggcgtc   Ccctgccgct   Ccccaaggag   Ggagaggaca   Gagtgggcag   1320     Agtgaggagg   Ttggggagag   Gagcccccag   Gcgtcgatca   Ggcgaaggag   Ggaggctcat   1380     Gcactcaccc   Acgccacgag   Tcaggagacc   Cagccaggtg   Tgaaatgctg   Cagggagacc   1440     Agggcttccc   Agcaccgagg   Ggaaggaccc   Gggcacattg   Cggggtcagt   Ccctgaaatg   1500     Aacttaatac   Ttttgtgcgg   Ataaccgtct   Ggcctttcag   Accctcgata   Tgggcctcct   1560     Ggagccattc   Aagagggaga   Ctcccacgta   Ataggctggg   Ctgtcactgc   Caacccactc   1620     Cgtgcccggg   Gcaggaacct   Cggacctcat   Cgagagccct   Tggcttaacc   Agtagaatca   1680     Tgccccaaag   Tgcaccttct   Tccaatccat   Cactatggta   Cttgccatcc   Ctgcctgttt   1740     Tccagtgcac   Tcaccgtccg   Tggaaatctg   Ttcaccgtct   Tcctccagat   Acacctaaat   1800     Gtagccctta   Tttagctgag   Aatacttggc   Ctacctcagg   Aagctgccat   Tccaagtatg   1860     Tctaaaaccc   Tgctgccccc   Atatcgtcct   Tgcagtcgtc   Atcctgtgct   Atttactctg   1920     Acccagctca   Ccagtcctca   Cggagtaggt   Tcttggaaac   Tgtcacctta   Agcaaaacaa   1980     Catataacaa   Aaccaaattt   2000       <210>   56   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PRLHR     <400>   56   Ataggtgtgc   Acggcggcgg   Gcagcgccag   Caccgcggac   Agcgcccaga   Tggccagcac   60     Agcgtaggcg   Ctgaggcgca   Gcgagatgcg   Ccgcctcagc   Gggtgcacca   Gcacgacgta   120     Gcggtccact   Gcgatggtgg   Tgagcgtgaa   Caccgacaca   Tagacggtga   Ccggctgcag   180     Gaagaagacc   Aggtggcaca   Ggccgccgcc   Gaacacccag   Ccgcgtggct   Cgaaggcata   240     Ggccagcgtg   Agcggcacgc   Aggcggtgca   Catgagcacg   Tcggacaagg   Ccaggttgcc   300     Gatgaggaag   Ttcgtcacgt   Tgtgcagccg   Gcgcacccgc   Gcgatcacca   Gcaccagcag   360     Gcagttgccc   Accagcccca   Cgaccaccac   Gacgctgtag   Agcagcacga   Tcagcccctt   420     Cagctgatgc   Accagctgca   Ggctctggaa   Gggcgtgacg   Gctggagcgt   Ccgcgccagc   480     Caccgacccg   Ttgcccgccg   Aggcctctgc   Gctctggttg   Gcgggagttg   Tgaccgccgg   540     Cggcagccca   Gaaaataagt   Cagaaaccct   Ggggccccga   Gtggtcgatg   Aggccatggc   600     Cacctgttca   Aaggtaatca   Aagtccgtca   Cttcccttgc   Catactccat   Ccgacctcct   660     Acaccagccg   Cgcccctccc   Ccatcgcctg   Agtcctccct   Tgggaataac   Cggccacaga   720     Acaacagcaa   Aagtagcaaa   Aagtgttgtc   Ctctcacctc   Tgtaaaataa   Acctaagcac   780     Ggttagaaca   Tacggtttat   Ttaaacgctt   Ccgcctctat   Ttacggtcct   Cgcagtccac   840     Gcaggcagac   Tcaggagcgc   Gatcctacct   Gggagtgggg   Tttggagagc   Gggaaagcac   900     Tcgcgggaag   Aaggggcaga   Atttctgctg   Gccctcggta   Gtcctctgcc   Cacgtcggtg   960     Atccggtctc   Gcttctccgc   Gggagctgaa   Cggatccaaa   Tgtttcccag   Tgggctagca   1020     Gcttcttaga   Gggactggga   Gcgcctcccc   Tcagctccgc   Cccccactcc   Agctcccatg   1080     Tatggaaaat   Aggggtggag   Cgcgctctgc   Catgctcggt   Gcttagagaa   Ctagtgaaga   1140     Ggacagtgtg   Gggaggatgg   Aatccgaaac   Gggaggaggg   Gccggcaaac   Ctggccagag   1200     Cagcgaagag   Gacgaatctc   Tactgcagga   Gcttgcacgg   Cccctggagg   Gtcagggtcc   1260     Ggaggagcgc   Acaggggagg   Agggcggagg   Agaggcgcga   Agcgtcaggc   Tatcgggagg   1320     Agccggtgca   Gtcttaggag   Ggaaggagcg   Gggaaggaag   Tagcggtggg   Agattgcaat   1380     Gcagctgggg   Gcttgagaga   Ggcacgactg   Acccgttctt   Aaaggctgga   Tcctgcctag   1440     Cggccaggtt   Gcggagggca   Gagacgctag   Agggctcggg   Ctgggattta   Acagcagagc   1500     Ctggagctgg   Tcgcggacct   Gaggaccctc   Accctcccgt   Ggccccgcca   Cacgagcccc   1560     Ctgcttggct   Gcagcgcgct   Cagcgggcag   Cgggtccggc   Caagccaaag   Gcaggagtca   1620     Gcaccacgga   Cagcttccgc   Tggatctgcc   Gcccctcggg   Cggatgatgt   Ggggaggagc   1680     Aggggaaaat   Gactagggaa   Ttcctgcccc   Tctctggatc   Cgggtgtttg   Gggaaggaac   1740     Ctggtccggt   Tcaaagacct   Gcctcgctgc   Ctgctttctg   Ggctggggct   Gagaagagta   1800     Gggtggagtg   Gaggcagctg   Agccgggggc   Ctgggggtcg   Gagactcatg   Acttttgctc   1860     Ctcttggtgg   Tcaccgcact   Cagtgccaag   Gacggcgtcg   Tcttttacct   Cccggggtca   1920     Gaaaatgcag   Ctctcctgcc   Agttattcta   Cacaggcaca   Cttcagtctg   Gcccagcgac   1980     Tccccggctc   Accctttctc   2000       <210>   57   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   PYGO1     <400>   57   Gaaatgggat   Ccttctcctg   Ttctgctgac   Attacagacc   Gcaaagcatg   Actccccccc   60     Aggccgcggg   Aattcggtct   Ctttgatgct   Gcggcggcgg   Ctcctcctcc   Tcgcggggcc   120     Gctgcggctg   Cgaggcaagc   Ctcggagccg   Aggcacggcc   Gagggcggtg   Gggacgcggg   180     Ccgactttgc   Aaagtttggg   Aggaggacga   Ggcctcgggg   Cggcggggcg   Gcggggcggc   240     Gtgcgggcac   Cggcggggct   Cagcggcggt   Ggccgggagc   Gcggcctggg   Ggcggccccc   300     Cacccggggc   Cggcatgtgc   Tgagggcgag   Tgcgccgccg   Ccgccgccgc   Ctcctcccac   360     Tccttcttct   Tcgccgccgc   Ctcaggagcc   Gctgacaggg   Gaagcaggag   Gctcgcggcc   420     Cggccctggc   Ggcacactca   Cagcgccctc   Tgaggaggag   Gtctgctctc   Tcgccgctcc   480     Cgagtcgcag   Acacaaaagc   Ccccagactg   Gagccgcctg   Taaaacccgc   Tctggggcgg   540     Gcgagggacg   Tggcgcggcc   Ccgcggcttc   Cccgccctga   Gctccccagc   Cccgcgcggg   600     Gacgggcttc   Ggggggcggg   Ggccgctgcc   Tcgtcccgcg   Gcgcctcccg   Ccaccgccgc   660     Cgcctcgcgc   Tccgcctcgg   Cccagccccc   Acggcccgcg   Cgcgcctctt   Gctccaagcc   720     Ggggctcgcg   Ggcccgcggc   Tcttgcagcc   Cgggtgggca   Gcgcgcgcct   Aggggccgcc   780     Ccgccccgcg   Cccggcgctc   Cctcgccgac   Cgccaggccc   Gagaacgccc   Gaccccgcgg   840     Ccgacgctac   Cgggcccagc   Tttcgcaagg   Aaagggcatc   Tccgaacttc   Gtcggaggcc   900     Acagcagcag   Gcgtctcggc   Ctcgcagcta   Gggatcggaa   Agatgaacgt   Accatgcgag   960     Gaaactttgt   Aagcgggagc   Tggagagttc   Tcggcgggca   Tgtggggatc   Cagetcccc   1020     Gactccgtgt   Ccgcgtggcc   Gtggtgtgga   Cacctgtctg   Tagaatgcct   Ccacttggta   1080     Ttttaacgac   Ttgactcttc   Aagaaagagc   Gacgtagaat   Aaataccaga   Aaggacggtg   1140     Ggcgggggag   Gggggagcgt   Gggtagaagc   Ggtgacgcgg   Ctggatctca   Tttagacgtt   1200     Aaattttagg   Aggaacaccc   Ccagtgtgat   Tgtaaattag   Atgtgatcac   Cggtccacat   1260     Tcttcagttg   Ggctgtgtga   Ccggaggcga   Cttaggtaac   Ctctctgggt   Ctcagttttc   1320     Ttgtctataa   Aaggcagtgg   Ggctacatct   Cgaaggtctc   Ttctagctcc   Gacattgttt   1380     Aacgcacttc   Tacgaaattg   Ttttccctgg   Tttttgtttt   Ttgttttttg   Tttttgtttt   1440     Tgttttgcta   Ggttttctgg   Tttaccactg   Ggcttatttt   Gatgtaagaa   Tcaccgaaaa   1500     Gcactcatga   Agcgtgggag   Gacacagaac   Tagctacaga   Caggagtctc   Gtccttccgg   1560     Agacagacac   Ccaactcatt   Cagctgcaca   Gtgtcacaga   Gaacagatgt   Taacatgaag   1620     Ccaatgtaca   Gcctcaacag   Ctgcatacca   Gacaatcgcc   Acagcggctg   Atcgtcgtta   1680     Agacatagcg   Tggccggagg   Caaatgttac   Cctttatcta   Ataagggtgg   Tctggaatta   1740     Tggaattcct   Gattagaaga   Gtcagactag   Gacaggctaa   Ggaaaatatt   Cttacaggaa   1800     Gcactctgag   Gagaaggttc   Ctcctaacta   Gaatgtaagc   Gccatgcagg   Caggaatttt   1860     Gactggctca   Ctgctgtatc   Ctctggtacc   Taatactgag   Taacacatag   Taagtgttcg   1920     Ggaaaatatt   Cattgatgta   Tgaataaaga   Gatttgaagt   Ggccctggga   Cgactggggt   1980     Ggcagggctt   Tggtaagtgt   2000       <210>   58   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   RYK     <400>   58   Aacacaccca   Atgcaaaaac   Caaaaaggta   Ttgaaactaa   Aaaggtctgc   Tacctggcga   60     Ttcattcact   Aaaaatatgc   Ttagaatcta   Agcatatgct   Ccaaatctac   Gtcccaagag   120     Ttggaggctg   Ccacgaacat   Ttggtgccct   Tataacctcc   Ccttctttct   Ctctcgtttt   180     Tttttttttt   Tttttttttt   Ttgtaaaagg   Gtaagcacag   Agcgtggcct   Ctactggagc   240     Atcaaaacca   Cagcaaaggg   Tttgcaagtt   Cagtctaaaa   Cgtgaatttc   Gagatattca   300     Aaatcgaggg   Ccctagagtg   Acacacatag   Aaagcgtcaa   Aaaaacttcg   Tgcagcaagg   360     Aaaaaaagtt   Gtaagggtga   Ctgactcttc   Tagggagaag   Ggctaaggag   Gcagtgagga   420     Gtaggggatg   Gggtgaatct   Gggtctatcg   Cggcggggca   Gcgagggcgg   Cacgaaggct   480     Gacccagagc   Tggggaccgg   Gcagggacca   Cacctcccag   Ccagcacggc   Aggcagagac   540     Cgggccgcga   Ggcgaatccg   Ggcgcggggg   Gcggggaggg   Tactcgcccg   Aggtccacgg   600     Ctcgcagact   Gatccgccgg   Cggccggaag   Ctgccccagc   Cggcccgacc   Tgcccgcccc   660     Ggcctcggcg   Gccccactca   Ccgatcagcc   Ggcgcacctc   Gtcctcgctc   Aggtagagac   720     Tcacgctggg   Ccccgcggaa   Gccgactgca   Gctccggggg   Ccgcggggcg   Ggggcggcgg   780     Cagcgccagg   Cgcgggcagc   Agcggcaaca   Gcgcaagcag   Aagcagcagc   Ggcggcggcg   840     Gcggggccct   Cagccgcggg   Cccccgggag   Gcaactccgg   Cccggccgcc   Ccaggccgcc   900     Cgcccacgca   Tggccgccgc   Cgccgccgcc   Gaagaggagc   Gtcggccgcc   Cgccgcaccg   960     Ccgcccaccc   Ccggccccga   Gccgctcaca   Gccccgagcc   Gggggcggct   Gcccagctca   1020     Tcgcaccgcc   Ggcccgtggc   Agccagcagt   Ggcttcagac   Ctccggagcg   Cgccgccgcc   1080     Gccgcctcct   Cgctgcatcg   Tccggagttg   Ggggctgccc   Gcgggacgcg   Cccgtgcgcg   1140     Ccgccgcctc   Cccgggagcg   Cgcacgcacc   Tttcgctctg   Ggcgggccgg   Cctgggcaac   1200     Gcgctggggt   Tttaaagtgc   Ctcggcgggc   Gaagggctcg   Ggtcaccctc   Tccgcaagag   1260     Ccggtccccg   Ccccaccggg   Tcactgcgtc   Taatgtttgc   Ttgtctattg   Tctgtaaccc   1320     Tcctttcccg   Acggacgggc   Caggctggag   Ccaccggccg   Cgcctgcagc   Tcagtgggcg   1380     Ccccaggtcc   Ccggaaacgc   Ctggatgcgg   Ccgttctggt   Tgcgaaaaag   Cagcatgctt   1440     Tcctgtttag   Tgggaaaact   Caaataaata   Gaaatcatcc   Tttatcttac   Catcggtgat   1500     Caactttatc   Gtttccgtat   Ctattattag   Aatttatact   Acatatattt   Gttttccaga   1560     Aagatcttag   Cacgctttac   Taaccctatt   Tttacgttac   Aaaattttat   Tttattttatt   1620     Atttttattt   Atttattttg   Agacgaagtc   Ttgctccgtc   Acccaagctg   Gagtgcactg   1680     Gcacgatctc   Ggctcactgc   Aacctctgcc   Tcctaggttc   Aagccattct   Cctgcctcag   1740     Cctcccgagt   Agctgggatt   Acaggcgccc   Gcaaccatgc   Ccgactaatt   Tttttgtatt   1800     Tttagtagag   Acggggtttc   Accatgttgg   Ccgggttggt   Ctcgaactcc   Tgacctcacg   1860     Tgatcaactg   Acctcggcct   Cccaaagtgc   Tgggattaca   Ggtgtaagcc   Accgcgccct   1920     Gccaaattgt   Tatttttttt   Ataatcgttc   Tgcatcacta   Taatcaacct   Gcctttgggg   1980     Ttgttaatct   Gtggtccata   2000       <210>   59   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   SDPR     <400>   59   Atttcacatt   Tgctttccgc   Aggcagacag   Gggacagtgc   Cttgtatgtg   Tgatccctga   60     Caggcaggac   Aaatgtaaaa   Atggctgtga   Gagccaggat   Gagcgagatc   Aagaatgata   120     Aggagttcca   Gcccgcctgt   Aaggaggcat   Agggggaact   Gacctggaag   Atgagcactt   180     Tgaaatggtt   Gcgtcggagg   Agctgggcgt   Ggttgttctc   Cagccgcttc   Acctgtgcgc   240     Actgcctatc   Catgcgctct   Ttgaccgcgc   Gcgtgtgggc   Gctgaccttg   Cgggacttct   300     Ccagcagctt   Gctcaccgtg   Ttgctggtgg   Aggcctggta   Cttggagagc   Ttggtgaggt   360     Cattctggat   Gcccttcacg   Gagccctcca   Aactgatctg   Tcgctgctcc   Atcttgtgct   420     Ggttctcctg   Cacagcgtct   Agcatgttca   Ccagcttgtc   Caggagcgtg   Agcaccgtga   480     Ctgcgttcac   Ctgtgagttg   Tcccggatgg   Cctcctctgt   Gttccctagg   Ttcaggctgg   540     Ggcttggtgt   Ggaggaaggc   Atcgggctgg   Ggctcgaggg   Cttttcctgc   Cgcatgtcag   600     Acccagggtg   Ctggaacttt   Tcggcctgtg   Cagcgtcctc   Tcccatggct   Aggcaggtgg   660     Gaacgttctt   Tctctctggg   Agctgcttct   Tgctcgggtg   Agaagttgcg   Gtggtgaggg   720     Tgtaggatga   Ggcccgctgg   Ttggagctca   Gggcaccagt   Ctccaggact   Ggcagaggtt   780     Cagacaggca   Acaactggct   Acgctgatca   Ggggaactgc   Attccagctg   Ctcttaaagg   840     Ccctactcca   Cccagtggga   Ggagaagttt   Acagaactga   Gaaccattta   Gggttcagac   900     Gtatgcacac   Acttcctaac   Cgcgttctgg   Gcacaggaca   Ctttgttgca   Ggtttagctt   960     Ttctttcctg   Ttccccttcc   Ctttcaatgt   Catatttcaa   Tcatgacttc   Atctagaggc   1020     Ggagaaaaac   Atgctaactt   Ggcccagctc   Cacagcttcc   Aattggctaa   Agctggtaaa   1080     Cttttctctg   Gctgctatgc   Tgcagatgca   Acagggtgcc   Tgtttctttt   Tcctggatac   1140     Aagttattgt   Aacggaaagt   Attgtttgca   Tttgccctag   Aactgactga   Tgggttgcag   1200     Aacaccgggt   Gtcctactgg   Gaggcataga   Gtttaaaggg   Tactgcagcc   Aagtttgtat   1260     Tattagtttc   Tcatttgcaa   Aggaatggga   Ctaactctga   Taatgataag   Gaaaacagct   1320     Cagttcttat   Tactcttgca   Gttgcagata   Caaaataagt   Taaaagagat   Tgaacttcag   1380     Ggatatttaa   Aaaaagtaat   Actgctgtta   Tgactgttat   Gtaatatatg   Gaaacttttt   1440     Gaatgaccac   Atttaaaaaa   Atgattgttt   Ttttcaagaa   Gtgagactga   Ggaaaaataa   1500     Aatgtggtct   Ttttaagaac   Ctaccgtgat   Gatttgtttt   Aactaacttt   Gagttggtga   1560     Ggagagactt   Tctcaaatgc   Ccatctctgc   Aaggcattta   Ttgacacgtg   Cccagaagtg   1620     Tctgttggca   Ggctgagttg   Gagtttctca   Agtggttcta   Atgtttgaca   Ttttaaaatt   1680     Cctgctcagt   Gaagtggcac   Acctgttctc   Aaatgtggcc   Ctcctcagct   Gaaccttggg   1740     Atgtggggct   Tattttccta   Aaatggcttt   Acatgcttga   Gttgatttta   Aacgtatcca   1800     Gcctttgaaa   Gtgctttcag   Caggaagttt   Gtaataggcc   Ttctatgaac   Aattttgaga   1860     Cgaacaaatg   Ccagctcata   Ccaggtcagg   Gattgataat   Ggaacaatgc   Cattcgtcaa   1920     Tagtaacacc   Tacatgtaag   Ccaatcaatc   Agcaggccat   Tggttatcac   Gttggttgaa   1980     Tctctgcctt   Ctgctatatg   2000       <210>   60   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   SKIL     <400>   60   Ttaatccttt   Gggtctgttt   Taaggtaaag   Tgctgagagt   Ttgggaagca   Aaaatttcta   60     Tttattggat   Ttcttttggc   Ttttctctca   Agaaggaagt   Ggaaaaagag   Tcttttcttt   120     Ttccctcttc   Ctccatttgc   Attctttgtg   Aggtttgtct   Gccttgtgct   Ttttgtcccg   180     Gattagtctt   Gttgaaggat   Ggagattccc   Aggcgtggag   Tctatagctt   Ttggcttcca   240     Ttaagtaaaa   Tcgctaacct   Ttttttaaga   Gaaagttaat   Ttttgcctgc   Agtcattcca   300     Gaaaaatagt   Gtacagggac   Tagctgaatt   Aatccactta   Aaattgtaac   Ttagttacat   360     Atggtagata   Tgttaactcc   Tatctgattt   Ttttggatga   Aactgttgtt   Ttgtttttaa   420     Ataggagatg   Aagtaatgga   Tttttttccc   Tcccttaaaa   Tggcatagct   Gagaaagccc   480     Cggtactact   Aattgagatg   Atctgcttaa   Gagtcttcat   Attctgaact   Cgaaaggcct   540     Tttatgttat   Attattgctc   Gctttacgca   Actccaaatt   Gctttcctat   Ttaaatgaat   600     Gttcttctag   Taaactggtg   Ttagatttaa   Agaaatcact   Caagcttcac   Cttggtaaac   660     Tgaactcagt   Ttaagattaa   Gaaactgatt   Tcggccgggt   Gcggtggctc   Acgcctgtaa   720     Ttccagcact   Ttgggaggcc   Cgggcgggcg   Gatcacctga   Ggtcaggagt   Tcaagaccag   780     Cctgactaat   Atggtgaaac   Cccgtttcta   Ctaaaaatac   Aaaaaaatta   Gccgggtgtc   840     Gtggcttgtg   Cctgtagtcc   Cagctactcc   Ggagtctgag   Acaggaaaat   Tgcttgaacc   900     Cgggaggcgg   Aggttgcagt   Atgccgagat   Cgctgcactt   Cagcctgggc   Gacagagcga   960     Gactccgtaa   Aaaaaagaaa   Aaaaaaaaaa   Taaaagaaac   Tggtttcaaa   Ttggcccttt   1020     Ggcctctgga   Gcaaattcaa   Atgtaactct   Tccccaaccc   Cccttctctt   Cttccagatt   1080     Aattaaaaga   Agaatgaact   Ataatccttg   Aagataactg   Ggcaattttt   Taagtcggag   1140     Gctgttctta   Ctggtgtgag   Gatttacaca   Cgtcttcagt   Ttttcagcac   Agaccagcag   1200     Accatcattt   Ttagaggaaa   Tactccctct   Gccctccttt   Ttggtttcct   Tggtggtaaa   1260     Gattaaattt   Ggttgcatca   Ttttgacttg   Tgtttgagtc   Tagattttat   Ggcacaagga   1320     Atggcataaa   Cttttcatgt   Gttttggtta   Aaacaaacca   Gaccattgca   Ttgaccctgg   1380     Acatctttaa   Ttgagaaatt   Ggtaacttta   Ttttaatatg   Tatatctgaa   Gaattcaaga   1440     Aaacaaaggc   Atcctcagag   Gtgtgcctct   Tttctttatt   Attagaggca   Aaacgaacaa   1500     Ttttatagga   Tttgtagtga   Aattatacca   Gattataagg   Agaaccaaaa   Ctaagtcgca   1560     Aaatttatta   Atttaagggg   Ctctcgcttt   Gaaagtttga   Gagtaagtta   Cgataggcat   1620     Ttgtatccat   Tcattacttt   Cctcttttca   Aataagcaac   Taaatagaaa   Tgctaatctc   1680     Agacttaatt   Atttaacaga   Agaggttacc   Atggaaaacc   Tccagacaaa   Tttctccttg   1740     Gttcagggct   Caactaaaaa   Actgaatggg   Atgggagatg   Atggcagccc   Cccagcgaaa   1800     Aaaatgataa   Cggacattca   Tgcaaatgga   Aaaacgataa   Acaaggtgcc   Aacagttaag   1860     Aaggaacact   Tggatgacta   Tggagaagca   Ccagtggaaa   Ctgatggaga   Gcatgttaag   1920     Cgaacctgta   Cttctgttcc   Tgaaactttg   Catttaaatc   Ccagtttgaa   Acacacattg   1980     Gcacaattcc   Atttaagtag   2000       <210>   61   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   SKOR1     <400>   61   Acacagtctc   Ccccatgctg   Agagaacctt   Ggaaagaggc   Tgtggctaag   Ctgaagctga   60     Taggagggga   Gcccctcacc   Cctgggacca   Gccaggatgc   Aggcagggac   Ccaagcttga   120     Gattcgggag   Gaagaggatac   Tcatgggaaa   Acctggggcc   Agctggagat   Gctcagccac   180     Cctcttttac   Tttaaaagat   Tttttttcta   Caggcaggca   Gggtctcctt   Ctcttgccta   240     Ggctggagtg   Cagtggtgca   Atcatagctc   Actgcagcct   Ccctctcctg   Ggctcaagtg   300     Atcctcctgc   Ctcagtctcc   Caagtagctg   Gggccacagc   Tgagcaccac   Catgccccag   360     Ctcactctct   Ctttctctct   Ctctctctct   Ctctctctct   Ctctctctct   Ctctatatat   420     Atatatatat   Atatatatat   Atatatatat   Atataatttt   Ttttttttgg   Tagagatggg   480     Atctatgttg   Ccccagctct   Tcttttccta   Atacctctgc   Tcaggcctgg   Gaggcttctc   540     Tgtctggttg   Gagcaaagaa   Ggctggtcca   Gggttccctc   Cttagtgtct   Gccagcctaa   600     Cttgcatccc   Caggtgcaag   Agagcctcag   Gagggcagag   Cccggcccca   Agacttcaa   660     Accattccca   Aggcctcctg   Gctctccctc   Tccccagaag   Cttaagcgtc   Ctaacctaag   720     Tagggccacc   Aagctctacc   Catcttcagg   Actctagaag   Agaggtgttc   Atgagcccct   780     Ggactctgga   Tcaatccttc   Actcgccttc   Actcctgcaa   Agtgggggt   Catgtgccca   840     Tcctacagat   Gcagatatgc   Aggcccaggc   Aaagtccatg   Gcccttcctg   Gagtcagcag   900     Cggaaccggg   Tctgggccca   Ccaggaccgc   Aattgttctc   Cctccttttg   Atgttcccga   960     Gaacagggag   Tcccctgccg   Tgaggagcgc   Tggtctcacc   Tatgatccca   Aagagcctgg   1020     Tccaggcagc   Ggaaacccag   Agggtacggc   Ctcccaccaa   Atccggaccc   Tctccagcct   1080     Cagtctctgg   Tccgcaacag   Gagtgaggtg   Ggcccggagc   Tctgagcacc   Ttctcaccgg   1140     Ctccaaggcc   Cccgccttct   Cctcactttt   Ggtctcgggt   Tggggcccgg   Caggccccgc   1200     Ccaggctcct   Tcacttcctt   Gggccagggc   Cgccgccgcg   Ccgggctctg   Ccctatgtgg   1260     Ccgttggatt   Aatatccaga   Tattaagtaa   Acactaaatt   Agcaaaacta   Caagaaaatt   1320     Ttacagccct   Ttgcatttgg   Caatcattga   Gtgttaatta   Gaaattcatt   Acaattaaaa   1380     Ccctgcctaa   Acagggcctg   Cgcgccttaa   Ttacatctga   Tttttaattc   Agatacgtg   1440     Tttacacagt   Aagcgctacg   Taccccgtga   Tttaccccaa   Tcctctttat   Actgtactaa   1500     Ttatgtaaat   Taaacctaat   Taactgacga   Aaactgccgt   Taattcaact   Agtaaaagat   1560     Atgtgcttgc   Ggaggaggcg   Cgtccgcgca   Gcctcagccc   Aagccggagc   Ccaaatggac   1620     Gccaaacccg   Gggcacggag   Gcagcgcggg   Ctcggccagt   Gggaggagaa   Gcgcgcaagg   1680     Cgcagctcgc   Atccagagtc   Cggctttccg   Acccctggtg   Ccaccgggaa   Gcggataaaa   1740     Gagagagaat   Cttcaataat   Gggggtcagg   Aaggccaagg   Gcagcgacgc   Ctgcccgctc   1800     Tggacagggc   Ctcaggaccc   Agagccccca   Ctgaggaaga   Ggagtcccgc   Ccatcccttc   1860     Ggagcctggg   Ttgcggtccc   Agctctgcca   Ctcactgcct   Gcctgaacct   Gagcaagtgc   1920     Cctggctgtg   Ccaggccttc   Ctcctctaca   Tcgtctaatg   Agggcgatac   Tgaaacgcag   1980     Cactgcgccc   Tccttaccgt   2000       <210>   62   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   SKOR2     <400>   62   Gcggctgcgg   Ccgagaggct   Ggcggcggcc   Actacggcgg   Cctcctgcaa   Ggagtcgtcg   60     Tcgtcgtcga   Agcgcggccg   Cttgtgatgg   Gcgtgcgggg   Caccagccag   Ctctgccaag   120     Ggcggcggtg   Gcggcggcgg   Cggcgggggc   Gcacccagca   Ggtgggggcc   Cagcagaccc   180     Ccgcctccgg   Ccaccgcggc   Cgcggcggcc   Acggcggccg   Ccttcacaga   Gctgagcggg   240     Tggcaggcgg   Ggtgcgcgcc   Cggctggggc   Agtgcgcgct   Tgcggctgcc   Gccgttgaac   300     Atggccttga   Cgtcctccca   Ggcgaagacc   Agctcgtcct   Ggggactctt   Gtcggtgagc   360     Ttgagatgac   Ggcgccacga   Gttgaagttg   Gctgcgtctg   Gctgagtgta   Cttggcgtcg   420     Ggcgtgcggt   Gggagtggaa   Aatgaacttg   Ttgggcgaga   Agtacatgtt   Gcagtagctg   480     Catttgatgc   Acttggcgcg   Cgagctgttg   Tagcgcgcgg   Gaatgaagct   Gccgcggcag   540     Ccccaggcgc   Actcgtgtga   Cacgtcgaag   Gcgaaattgt   Ctggcagctt   Gggcggcctg   600     Ttttcgccca   Ggaacgactt   Gcacagacgc   Tcggcctcgc   Gtttggtgat   Catgccgcag   660     Cggcgcgatg   Agatgggcat   Ggccccggca   Cgccgcagga   Tctccagttg   Caccggcgtg   720     Cactgcacac   Acgtgatgcc   Cagtgccacg   Cgacggttgt   Ggatctcgtt   Gtagctgaag   780     Ttcttgagca   Gagtgttgga   Gatctgcgcc   Aggcacaggc   Gctcttgccc   Gtcgatcacc   840     Aacgacacga   Tgggaatgcc   Gtagagatagc   Acctggccca   Cctggttggg   Tttgaggttg   900     Gcgtgccctg   Gccgcggctg   Gctcagcgtg   Tcgggctgga   Aggcgctcga   Cggcgacgcc   960     Agcaggatgt   Cgttgggccc   Tggcagcgga   Ctggaagcca   Tctccgccgc   Agaaccccgg   1020     Gccgagccct   Acaggtctgc   Cttggacact   Ggaagggaaa   Ggagaaagcg   Ttgacttgag   1080     Cctttcaga   Ctaaaacaga   Ggggtgggat   Gaatcgctaa   Ccaaagaatt   Agaataactt   1140     Tcttgctttg   Gttaagacac   Gattattact   Ggaaaaagtg   Accaagtttt   Gaacacaaga   1200     Aagtcatctc   Ttaattccct   Tcaaggccat   Cctttagaaa   Tgcaggaatt   Tgcacttctt   1260     Aacatttaaa   Gtgaattaac   Tatgtatttt   Cctcaaaagc   Agtgaattcc   Taagaaacct   1320     Aagaccttat   Cccggattta   Taggagccgt   Tggaataaaa   Tggcttgctt   Ctagaaatta   1380     Aatagtaacg   Atagttgtaa   Ctagtacaga   Taataaaagt   Tacggaaaac   Tggggcttgg   1440     Ccattgaaac   Ccaaatttaa   Agagctgtca   Ttctcatttg   Cttggagata   Gattgatttt   1500     Ggttaaaaag   Taacccccaa   Aaccctttaa   Aaagtgattt   Tcttggtgtc   Tatggtttcc   1560     Ttggggaaat   Tcattattgg   Ttgaaacaca   Ggtcattaaa   Gcaaaacgaa   Atcagccttc   1620     Tccctcaccc   Ttgccattag   Atattttgtt   Actgtaatta   Gaattatttt   Tttgaaaagg   1680     Tgaaaaatgt   Acaaagtcat   Atacaccgtt   Gcaccaaaat   Agaatgtttc   Agtttttaaa   1740     Aaacctactt   Gctgaactga   Gtggttctgg   Tctcagatgg   Ttaggtagct   Taaaaacatg   1800     Aagttgaaga   Tggtagtcat   Ttaaaaactg   Ttttactgtc   Atttccatga   Cgataagaaa   1860     Gtaagtagag   Gcaagggtgt   Taaacccaga   Aacagtacac   Aggaatgaac   Aattcttggg   1920     Gatcttcatt   Ggcagacttc   Aaaaggcaaa   Ttttttagct   Tgatgtgaac   Caccttctgt   1980     Gactcttttc   Ccctaattta   2000       <210>   63   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   SLC25A2     <400>   63   Atcatagtag   Ctttcagtcc   Agaatataag   Gctactattc   Cttcatttct   Cacaacactt   60     Aagagggtac   Caataaatcc   Tgcctgtttc   Ccatacatgg   Aaagaacttg   Aattctggat   120     Tatacatacat   Ccactgggaa   Cacgacaagc   Cacaggcaaa   Ttccagcaac   Tccaccactt   180     Aacatcaaat   Ggacagggcc   Tagttcatct   Tttgatctcc   Ctgacgcaaa   Aaacgatcgg   240     Ctcagttcat   Agccaccaaa   Gaaaaagaaa   Taacccggta   Cttcttgaag   Tagagtactc   300     Gagagtccat   Ggtagaagcc   Caaggggcca   Tcctttttaa   Ggataccctt   Cacgacagac   360     Caaattgtat   Tatggctttt   Tgctatcttc   Cctgacatct   Ccatttcata   Catggtctgt   420     Agccggcact   Tcacaagctc   Agtggggcag   Agagccagtg   Cagcaaatgc   Agaggcgaag   480     Gaccccgcgg   Ctgcagtctg   Gagatcactc   Agctttgcct   Gcttgtccat   Tccagccact   540     Ttcctgacaa   Actgctggca   Gaacccgtag   Cacatgaaga   Ggaccgagtt   Ttcggcgacg   600     Taggccataa   Gtgccgggcc   Ggtgcccttg   Tagaagcccc   Ggagacccac   Ttgggcgtat   660     Gtcttcagga   Agcagtcggt   Gaggcccttg   Tacaggtcag   Ggaacgtctg   Catcttcact   720     Tttattgtgt   Cgaagggctg   Cccagtcagt   Acacacgctg   Tcccccctgc   Ggcccccgct   780     Gtgaggtcga   Tggcggcttg   Gatgccagga   Ccggacttca   Tgttcgctca   Ctcgtctgag   840     Ggtcccagtg   Gaaggcgact   Aactccccag   Agcgtgagac   Cggcttttca   Cgtccagccg   900     Cagcgagcgc   Ggggaatgga   Gttgggggtg   Gtggggtggc   Tctaccgcct   Gttctgggct   960     Ctcaccccag   Tgcgggggaa   Gccgctcaac   Cctacgctcc   Gccgcgggcc   Gccccctccc   1020     Cgcgcactaa   Aataaccccc   Tgctgccggc   Ccaggccgcg   Gctcactagc   Gttcctgcgg   1080     Ctcctggcgc   Actggccggg   Cccccagccg   Cctccagcct   Ggagccgcca   Tccctgcacc   1140     Cgcaggcggg   Ggacgcggac   Cgaataaata   Cttttagtgt   Actgcgactg   Ggcgcggtgg   1200     Ctcactcctg   Tatcccagca   Ctttgggagg   Ccgaggcggg   Agtagcgctt   Gagcccagga   1260     Gatcgagacc   Agcctgggca   Atatggcaag   Actccatttc   Tacaaaaacg   Aaaaaatacc   1320     Cgggcgcgat   Ggcgcgcgcc   Tgtggtccca   Gcaattcagg   Agaatgaagc   Gaggatcgct   1380     Tgaacccggg   Aggtcgatgc   Tgcagtgagc   Tatgatcgca   Cactgcactc   Cagggtgggc   1440     Gaaagggtga   Ggctctgtct   Caaaacaaaa   Ccaaaaccaa   Gaaaacatgt   Aaagcttttc   1500     Gataaattct   Tgcaattatg   Gccgggaact   Ctagacgccg   Cagttcagct   Ggcggcaaaa   1560     Gaaatgctgt   Cctaatcagt   Cagccctgct   Tcttttcttt   Tctctctttt   Tttttttttt   1620     Gacttagggt   Ctcactcggc   Cgcctaagct   Ggagttcagt   Ggcgcgatcc   Tggctcactg   1680     Cagccccaat   Ctcctggcct   Caggcgatcc   Tctcacctca   Gcctcctgag   Tagctgagac   1740     Tagagggact   Acaggcgcaa   Gccaccacat   Ctggctaaat   Tttgtattgt   Acagacgggg   1800     Tttcgccatg   Ttgcccaggc   Ttagctcgaa   Ctcctgaact   Caagcaatcc   Acccactggc   1860     Ctcccaaagt   Gttggggctt   Acaagcatga   Accaccacac   Ccggcctatc   Ccacgcttct   1920     Taccatgcaa   Aaaacaaaaa   Caaacaaccc   Gaaaagaaga   Tgccctcact   Tgaatagacc   1980     Ctgaattcag   Agggtcaatc   2000       <210>   64   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   SSTR1     <400>   64   Acaataccca   Ctctcttttc   Ttttaactta   Atgaacattt   Attttctctc   Catatgtgct   60     Ggtttgtaa   Aggaaaaata   Aatataacta   Aacaccaatt   Gtacattcca   Ctttaaagaa   120     Ggcaatttgt   Tcaggtaaaa   Taatgggtta   Aaacagtttc   Agccgtatga   Aatttcaaat   180     Tccatcctag   Cacattcctc   Atatataatt   Gcacacattc   Ctatgaaagt   Ctgtcattta   240     Ttttagtctt   Tgattgctat   Catcaacaca   Ctacagaagt   Tattctttcc   Tgttcaagac   300     Aattagtttt   Gggaactaaa   Acacatgcag   Tatatgtaag   Tgattacctg   Gataaagcaa   360     Cagggcatta   Ggaaatatac   Ttttttgttt   Ttaatttctg   Catccatttc   Ttcattctgg   420     Accggtacag   Atagcctcca   Tgaggagttt   Agcctctcct   Tggagtaaac   Tctactgaga   480     Ggaggaaaac   Tgagacttac   Agtacagcgg   Gcacagcctg   Gttgaggaga   Aggagaaact   540     Aaggaaaaac   Tggagacagc   Aaagcttgaa   Ggaggcagag   Cactaagctg   Ctgcgggtca   600     Ctcttcctgt   Gaacaggcta   Gtttcaaata   Aaggcttgca   Gggatcttac   Cgagcaaagc   660     Aacgtttatg   Aaaaggaaca   Gggaagttgc   Atggagtgtg   Attcttcctt   Ccacaggaac   720     Agttggaaag   Ccaaagagac   Ctagagataa   Gaatggtggt   Aagtcccagg   Gttcgtttaa   780     Aatcctgata   Acggaacata   Cattctttct   Tacgggaaaa   Ccgttttgat   Tcttaaatga   840     Agtcagtgag   Cttcaggctt   Gcctacattg   Atatctccta   Atggtttggg   Cacgtgaccc   900     Agagccagct   Cacaaatcaa   Gcctcagaaa   Gagctgacat   Cctagctctt   Cccggaaaaa   960     Ctcgaatgtc   Gccctgccgt   Tcctggggtt   Ggtgacaggt   Ctggtcatcg   Cacggcggca   1020     Gctcctcacc   Tggatttaga   Agagctggcg   Tccccgcccg   Cccaagcctt   Taaactctcg   1080     Tctgccagaa   Cccgccaact   Ctccagggta   Caaagtacag   Cagggacgcg   Ggtggagccc   1140     Ttccaagcgg   Cgcagcctta   Tctttcccga   Gtgaacacct   Aggtggattc   Ccaacaccgc   1200     Gcctggcacg   Tttctggagg   Gagtctcaag   Ctcctccaga   Gctcccagct   Gcgcgtcctc   1260     Gtttctgcag   Tcgatattcc   Tgtgggagac   Acggggggct   Ctgagcgcta   Cgagctttat   1320     Taagagattt   Gcgaatggtt   Cactcaggtc   Cctgaacact   Cccaatagcc   Taagctgcct   1380     Gctgtgttat   Agcgcagaag   Cccttaacgc   Acggtggttg   Tcctttcttc   Tcataacgct   1440     Cgcagcttag   Ggccagtttc   Cgcgattcta   Agagtaattg   Cgtgggcacc   Tgtgctgggg   1500     Ccaggcgcaa   Gaagagggagt   Tggtctgcgc   Gaagatcgtc   Aacctgctaa   Cagaccgcac   1560     Atgcactttg   Caccgaccat   Ctacgtctca   Gtctggaggt   Tgcgcacttt   Gggtaaggag   1620     Ggcccggaac   Ttccctggcg   Ggtctgagct   Gcaaggcaag   Cgagggtggg   Aagagggaat   1680     Ttagggttct   Ggactgcggg   Acgggagaga   Agctggggtc   Tccagagaaa   Agggcagcaa   1740     Tggagggaaa   Ctgagatgaa   Ctccagacat   Ccatgttcat   Ggatccgttt   Gagtctttgc   1800     Tttgggtagg   Agaggagtgg   Aatgagacag   Aatctatacc   Tttggttccc   Acccgccctc   1860     Cagtaaggcc   Gaggaactct   Cttggttcct   Ctgagagcaa   Gaggcagatg   Gtgctgcgag   1920     Ggaaccccgg   Aaggagccac   Taaagttgag   Cagagtgcag   Gactgggaag   Gaaaaaaatg   1980     Gggggcgggg   Gggacaagcc   2000       <210>   65   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ST8SIA5     <400>   65   Tgcggtctct   Ccgggtatta   Aatggattta   Tcgtcagcct   Ggttgcttgg   Aattctattc   60     Tgtccttcat   Ttttcacagc   Ggaacaaagt   Tgtctggacc   Ctccagccag   Cgctgggcag   120     Aagcaagcaa   Ggatgctctt   Ggaaacgcgg   Tggcccaagc   Ctaagcggcc   Atgctcgggg   180     Ctaggagcgg   Accccacggc   Cactcacccc   Ggggcgctgc   Gaccgaagct   Gccgcggcca   240     Ctgccacccg   Ggggctcgcc   Ggccggctcc   Gcgcatcccg   Ccctctcaat   Ggactttctt   300     Acctcttaat   Gtagttcctg   Ccatacagga   Tctgttgcag   Caaggtcacc   Aaggcaaagg   360     Cgcagatgaa   Gatgaagagc   Aaagttcggc   Tccccaacaa   Atcccggttg   Gccgaggggt   420     Ccgcgtagcg   Catcctggct   Accgggcgcc   Gcgggcgcgg   Ggtacggggc   Ggccaggcaa   480     Tgactcgcgg   Ggttccgggg   Cccggggggg   Cgcgcggccg   Acttggcgcc   Tcacggtgcg   540     Gtcaggcagg   Cgggggactt   Cgaggggcaa   Agtttctggt   Tggcgcggcc   Ggagctgggg   600     Gcatccaagc   Gtcgcaggcg   Ctggggcggc   Aagcaggaca   Gggccggtgg   Cagggagctc   660     Tgccgcggcc   Aggggccttc   Cccacccccg   Ggtaccttta   Cctccaggcg   Ccggtgccgg   720     Gtagccgccg   Atttccccgc   Ggaggggaga   Cgccaggtgc   Cacgagccgg   Aggcggcccc   780     Tcccgccgag   Gtggcggcca   Atggggagca   Agacccgggc   Tccgtcccct   Gtgcgcccca   840     Gcgcgccgcg   Catcgacccc   Tccagtccgg   Cgccggatcg   Cggttgccca   Gcgcgctgtg   900     Ccctgccggg   Ggcgggccac   Gtttgatctc   Cgggcccgca   Gcaagggatc   Gcgaaggttg   960     Gcctccggtt   Ctgccgatag   Ggacgggggg   Agggggcgta   Caaaacaccc   Gcgcagtctg   1020     Gctaatgata   Ggcgggccgt   Ggggaggggg   Aggggcggag   Cgcaaaacgc   Cgggtttgaa   1080     Tcttggaatt   Aaaaagaggg   Caggggctgg   Gcgcggtggc   Tcactcctgt   Aatcccagca   1140     Ctttgggagg   Ccgaggcggg   Cggatcacaa   Ggtcaggagt   Tcaagaccag   Cctggccaat   1200     Atggcgaaaa   Cccgtatcta   Ctaaaaatac   Aaaaaacaaa   Attagccagg   Cgtggtggca   1260     Cgcgcctgta   Gtcccagcta   Cttgggagac   Tgaggcagaa   Gaatcgcttg   Aacctgggag   1320     Gcggaggttg   Cagtgagccg   Ggatcgcgcc   Actgcactcc   Agcctgggcg   Acagagcgag   1380     Actccgtctc   Aaaaagaaaa   Aaaaagaaaa   Aaaagagggc   Aggaagagga   Aacaacagtt   1440     Gcggagctgg   Acttgatgga   Agggagcatt   Tgcgtgcggc   Gcgcagggca   Ctgagtcacc   1500     Atcgtggccg   Cgtcctcgcg   Ctctcctagc   Gatttctccg   Gagaaagcgg   Agcaaggtca   1560     Gccgggcagc   Ccttcaagga   Cggcgcgccg   Ctcctgcatg   Ctgatggcct   Gcggggctgc   1620     Ctgcccgtgc   Cccggcgccc   Aactcctaca   Aggaagaaat   Tcaggggctc   Cccgcccccg   1680     Ccacagtcct   Cttccccctc   Cccagctgca   Actcggcagc   Cgttcgtcaa   Agacctgtt   1740     Gtcaccgaga   Cactgggacc   Ttgtctcatc   Cttggaacca   Ctcgtaaatc   Ttaggtcagg   1800     Cagccggcag   Ccttcgggga   Ccacagtccc   Cccaaagctt   Taggaagcca   Gttactacat   1860     Ccggaaagat   Tcgtgcttca   Gaacgcaagc   Cagggagaat   Aatcacagaa   Acgcaatgcg   1920     Aatgtcgtgc   Ctctcagaaa   Ttcttagcct   Gaaataccgt   Ccccaccccc   Caacccggcc   1980     Aggcgacagt   Cctgtcatcc   2000       <210>   66   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   TBX15     <400>   66   Acaggtgaaa   Gttgaggtct   Gatctgcgcc   Tttacaaact   Cctgcaaatc   Ccaaatccat   60     Acgtttttct   Tccagatctg   Ctggtctcat   Agacgctgca   Agtccagagt   Cactttagtt   120     Gcagatctgg   Aattttgggg   Ctctgacaaa   Atgttaacct   Gtccaaaatg   Ccagaaaacg   180     Attctgataa   Tttcgcgtca   Gcccctaggt   Gctttagaat   Attctggttc   Ctcctggatt   240     Tcgccacaca   Ggttttaatg   Ttcctactga   Acgttttcta   Agcaaatctg   Ggtaaggcaa   300     Aaggaaacaa   Acaaacaagc   Aaacagaaag   Ccctgttact   Aaccagggtc   Ttgtaactga   360     Aaattcaaag   Accgcttcct   Ccttccagct   Ctacctggtg   Gagaaggaga   Cacaggcgcc   420     Ttgagagcaa   Ggggcgggcg   Gcggagcgcg   Gggtttaggg   Cgagctcctc   Aggcgtattc   480     Cagctgggcc   Ccctcacgcc   Gcaaatactc   Tctttcccta   Cggcccgaac   Gctgggctgc   540     Gcttcgcctg   Ttccgggctc   Ttgttgcaga   Gaacctatgg   Agaggtgaca   Ggcaagaaca   600     Gctaggaact   Ttaacagaag   Agaaggagct   Ttttcaaaat   Tccctgcaaa   Tcccgttacc   660     Tcaagaccat   Ggctttcccg   Gccagctgat   Ctccccccg   Gccgccccct   Gccttttgcg   720     Atctctaagg   Actgcattca   Acatggattt   Ctaaggaatt   Aaaaaatcca   Acgctcctgg   780     Ccattcttaa   Ttcccacacc   Tcttcccaag   Ttacgccacc   Ggtcgaggac   Ggcaggagac   840     Ccccgagtgc   Agagaaagct   Caaaccggca   Gcgaagtcgg   Tcctagccaa   Gctgaaaaaa   900     Cgtctcggat   Ttcgcggaca   Gcggcctaga   Cacagcccga   Tcttccagtc   Ctagtgccct   960     Ggtcgagacg   Gttctatcct   Tttgcaaaga   Agccggaaag   Agctgggtcc   Cgggggcggg   1020     Ggacagactg   Agaggccaag   Caggccagtc   Gtgacgacag   Ccaggccctt   Agaagtctcc   1080     Aaacctgaaa   Gtttaggtta   Gggggcccac   Agcctgttaa   Gatttcttgt   Tgttgttttc   1140     Gcgaggcccg   Ggagaatcag   Ctctcccacc   Ttgcggcaag   Aaaagatgac   Ttgtcaggcc   1200     Tctgaaacgc   Cgaattctct   Gccggactgc   Ggaggggccc   Agggaaatct   Agtctttatt   1260     Attacagttg   Gaagtgttct   Ggtgctgaag   Gcaaccacag   Tgttgtgaat   Tcaccttggg   1320     Cctctttgga   Caagaggcta   Cttttgcccc   Cttccttcac   Ccccgcccca   Aattaggatc   1380     Caaccaggat   Gtcaggaagc   Tagcatccca   Ggcgaatgca   Aaaagaacaa   Tggaaaagcc   1440     Accggatgag   Tgtgattcag   Ccaagcctga   Cctccccgga   Gcctgtgtct   Caggcttgga   1500     Ggtccccagg   Gagcacgaac   Atgaactctg   Gggagctgga   Agcagggtac   Tggtccccgc   1560     Ctcctgcagc   Tctgcccaga   Ggacttgggg   Agcccggtag   Gagaggcgca   Ggatctccca   1620     Cttcagtcag   Catttggcgt   Tgcttccagg   Agtcgtcgct   Gaaagtcagc   Gcgcattcac   1680     Tgctaccggg   Cttcagcaga   Gaagctggag   Acaaggcaga   Cgggaacccg   Caatttcctt   1740     Ccccagggggg   Tggggcctct   Ctctcacctc   Ccaactctgg   Tgtcgcccgg   Cgttttccgc   1800     Ctgcggctgg   Agcctgcccc   Taccaagctt   Ggtggggtag   Caatggggcc   Ggcctctaga   1860     Ctttcccagc   Tcttttctca   Tccccatagc   Cggtatctcc   Catctctctc   Tggcagcctt   1920     Ttgcctttca   Cagtttctca   Caggcctggt   Ttggactgag   Aagcgggtac   Accatatgcc   1980     Tcaccctctc   Tgagaccatg   2000       <210>   67   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   TBX5-AS1     <400>   67   Aatgtggggc   Aaccggggag   Aaagccagcc   Ctcctttgct   Atggtgctca   Ctccacctc   60     Caggtttgtt   Tgcaaacaga   Tattttccct   Ttgcccaggc   Gatgtattta   Tttgtgaaaa   120     Caccctcacc   Ctccaagtca   Gcttggaggc   Ctttaggctt   Gctggcaagg   Cgaccctagg   180     Ccgaagacac   Gaaaaacaaa   Catggcatcg   Gaagaaggct   Gaaccgctac   Atctccagta   240     Gagggaaagg   Gaaatccaga   Aagaccttcc   Caatcccttt   Aagttctcag   Agatttgggg   300     Ataaaattaa   Ttcccataaa   Taatcttcag   Gcccctccag   Agagagaaaaa   Tctggactct   360     Cccaggtaat   Agcccagcca   Gatttgctta   Gctcattgag   Cacagatggt   Ctgggccacc   420     Aagcaaaata   Gggattttca   Aacctttcga   Gagaatccat   Tcttgccagg   Tgacacacga   480     Agccattctt   Atttcgttca   Tgagaagtag   Cagcacagca   Agagaagatt   Cagcaagact   540     Aagacggggt   Gaaaagccaa   Ggagggccaa   Gtgcaaagag   Aaacctattt   Cccccctcag   600     Tcctccaggg   Tgaaactcac   Ctccaactat   Cccacctctt   Ctttggagcg   Caaaagccag   660     Gagtgcgcct   Cgctggagag   Cagggctcag   Gtgaagactt   Tgaaaaggac   Caccaaaaga   720     Gacctcttta   Ggccaggtct   Tcttccaacg   Tctgtcaaga   Agagcacgta   Cctcccagct   780     Caaggttggt   Ttgtggtctc   Cgacaaatta   Aatattactg   Tttattacca   Ggcatacccc   840     Agtaaaataa   Agaggcaacc   Aggcgatagc   Gactatctca   Ccagccgctg   Cacctatagg   900     Acttggagac   Gtcacgagtc   Acgcaaccgg   Cccgcgcgct   Gtcacgtttg   Gctggggggc   960     Agcggcggga   Ggtaaatttc   Tctccgtctt   Cgcctatcag   Tgccgggtct   Gcgcagccac   1020     Aggttccgga   Cgtcttggcc   Ccgggaataa   Ataaagacat   Aaaccaaccc   Ggctttctcc   1080     Ggaggaatga   Gggtgatgaa   Cataagacac   Aaatagagcc   Aagatcgact   Ttcttaggaa   1140     Gggggagagg   Agggaactct   Tcacgaaggg   Aggtgggagt   Ccacctcaga   Cctctattgg   1200     Aaggaaatcg   Agttgttccg   Ggggactgag   Gtctcttgca   Taaggcatgg   Gatccttatt   1260     Attattatta   Tttattttaga   Atcccccgcg   Gaggagctct   Gggcaaatga   Ataccgaggc   1320     Gccgctctag   Ctggttaggc   Ttgggatgcg   Ataactcagt   Gccctcttgc   Agacttgcat   1380     Gagaatatatt   Actgggttgt   Cgtggagggg   Acacgagaca   Gagggagttc   Tccgtaatgt   1440     Gccttgcgga   Gagaaaggtc   Caagaatgca   Attcgtccca   Gagtggcccg   Gcaggggcgg   1500     Ggtgcgagtg   Ggtggtggag   Taggggtggg   Agtggagaga   Ggtggtttct   Gtagagaata   1560     Attattgtac   Cagggcccgc   Cgaggcacga   Ggcactctat   Tttgttttgt   Aatcacgacg   1620     Actattattt   Ttagtctgat   Caatgggcac   Aatttctaag   Cagcgcagtg   Gtggatgctc   1680     Gcaaactttt   Gcgcaccgct   Ggaaacccac   Taggttgagt   Tgcaaaacgt   Accgcgtaga   1740     Cgcccctggt   Ggcgccgaga   Gaagagctag   Gcctgcccag   Cacagagccg   Gagagcgtcg   1800     Ggccttccgg   Aagggtaagt   Tctccgccaa   Ggggtcccga   Gggagctgga   Cgtctgaatc   1860     Tggacttgcc   Cccagcttcg   Gggttcgatt   Ctgggttttg   Cgcgtcccca   Acccccaggg   1920     Ctttccgaag   Catggcctgg   Ctccaggccc   Ggtcctgtaa   Ggactggaac   Ggcagcaaaa   1980     Tgtgcaggga   Ggcagtcggc   2000       <210>   68   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   TCTEX1D1     <400>   68   Tctgtgagta   Gagattggga   Tgggcaaaaa   Tatctatttc   Tcttcttcca   Acactatcct   60     Aacactgtgc   Tccaccggaa   Tcccaatgta   Ttactgtcag   Ctaatgctaa   Ttccagcagg   120     Accactcatca   Agagccatgc   Cctgtgctag   Atgcttggag   Gcatcttgtt   Tctgcttcca   180     Atgattgccc   Actacaggag   Ggtccctata   Gtgtttattt   Tgtttgcttt   Tggtttgggg   240     Aggcccaaac   Caggcttagg   Ctggggatag   Tcgctgaaga   Agaggaaaag   Cccattcata   300     Ccagcaggta   Ggtcctcaac   Cccaaacagc   Ctcatttcaa   Agcttcttag   Acattaacag   360     Gctcagaaga   Gtcttgttaa   Ggaaagcgaa   Ggaacccagc   Ccggtttgta   Acacattgga   420     Gttaagacca   Tgagtttcag   Gggccttggg   Catattattt   Aacattttag   Aatctcaatt   480     Ttccaaatcc   Tttaaaggga   Aaacattcct   Ttcttgacag   Agttattggg   Acgactaaat   540     Cccaatgttt   Gtcggtatct   Ggggtatctg   Gccaatgtaa   Gtgctcattt   Acctccacat   600     Tccaccgcct   Gtgccttgga   Gggggaacgt   Gcgaagcagc   Gttaggagcc   Gggaaaaggg   660     Cagggctact   Ttactttgtc   Tttgcgcttc   Ggatttcctg   Tgctaggaaa   Ccgcagcact   720     Tcccactcct   Gcccctgatg   Tctgcgggaa   Aaggaacttg   Atgaggggcc   Ctaggggtgc   780     Aaatgtcttt   Agtcccaaat   Gtcttcctcg   Ctacacaatg   Aaccagttcc   Cctccagctc   840     Gccgccaacc   Caggacgcag   Cccggctcag   Agtgaccccc   Agtgggcagt   Gaagatgaga   900     Tcctctacat   Ccttagggca   Gctcagaggg   Ccactcagcg   Gccaagtccg   Gccggggagg   960     Gccgagggct   Ctgtttgagg   Tcaccctgga   Gaccggcctc   Agagctcagg   Gagagtgcgc   1020     Gggcggccgc   Cggctgaatg   Aagcctggga   Cgcgggagcc   Gcgccgcgcg   Cagtgtctgc   1080     Agtgccggag   Gtctgggagg   Ctccgggcga   Agcctccctg   Ctgcaggtag   Ggtcgcctct   1140     Ctctgcagcg   Cgtctggacc   Ccaaaggaag   Gatagggggc   Aagggatcgg   Ccctttgttg   1200     Gagaatggcc   Ctacttggcc   Ccgatctctc   Cgccacctta   Ttcctcctct   Ccccaacaca   1260     Taagaaaaaa   Tgatcccaaa   Tttgggaact   Gaaagtcggt   Cccaacggtt   Cgtcccctgc   1320     Cccattgcat   Ggctgggggc   Tgggcttcaa   Gagtgatggc   Caacgcagag   Ccggccagca   1380     Aggtcatccc   Ctgacccggg   Gcggtcttcc   Tgtggctggc   Cgcacccatg   Aggaccdcca   1440     Ggtcccaact   Ctggcctttc   Ttggggaggg   Ggcggcctgc   Agggcagctt   Tggaaacagc   1500     Tgaggccgag   Atgggtctat   Gtggctttgc   Agcaaaacct   Gaatgaccca   Cctaatcagg   1560     Ctgtgtgtct   Ttccacactc   Ataaacacac   Tcaccttcgt   Acacacgaac   Acagacacac   1620     Ttatacacac   Aggcacctgc   Acacacagag   Atgcacactc   Acaggtacac   Actcaaggac   1680     Gctcacactc   Acgtgcacac   Acacaccacg   Ctgcctgcct   Cacccacaca   Cagcacctct   1740     Gctctgacat   Tgatgccact   Gggttttagg   Gtatgttctt   Gtgtgcccta   Cctactcaac   1800     Tgccagctcc   Ttgaaggcat   Ggattctctt   Ctatttttat   Gctttggtgt   Ctagcacagt   1860     Atttccttat   Cggggctctc   Acatttatag   Attattagaat   Aatttaaatg   Aatacttaaa   1920     Tttgtaggta   Gacaatgagg   Gcattattag   Agttatagtc   Caagttctgg   Gaagtccatt   1980     Gctactacca   Gctttttaac   2000       <210>   69   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   TEAD1     <400>   69   Taaataatta   Taacaatcac   Ccgaaacttt   Agacggttct   Gtccccagtg   Ggtcgatttt   60     Acccgttttc   Tgatttaccg   Actgcgtcta   Tgtcactttt   Gcgtcactac   Ctccaatggc   120     Aggtttaaaaa   Tgattccttt   Aataatgaaa   Tgaagtttct   Caataatgaa   Agggctaact   180     Taaagtcgcc   Ggatgcagca   Tttcaaagtt   Taggaagtta   Cttttgaaaa   Gtacaaccgg   240     Cagagatgag   Tgaacttagt   Tttttaactg   Acttggagaa   Gaccttgcta   Gcagggcagg   300     Tttattacga   Actctgtaat   Tatccttctt   Tgctaagcta   Aaggtttcc   Tttcccaacc   360     Gtaagacaga   Tttcgacttg   Agtgagagct   Gtgaactttt   Ataaaagtga   Aagggaagag   420     Aagaaatggc   Aggctgggaa   Tctggcccgg   Agacggcgtc   Caccgcgctc   Gagagcaaca   480     Atctgcatca   Ccagaaaggc   Aacttctcta   Ccctacactt   Gcagacttcc   Gcgagtccgg   540     Gagcactcaa   Cgcagtcacc   Cgcgcttccg   Cgtcccggac   Tagggaaact   Gaggcacggt   600     Aggcgcgtcg   Cgcgcaactc   Ccgcctcggc   Gcctgccccc   Tggaagaaac   Ccaggcttcc   660     Agaggtcttc   Gcgcgagcgc   Agggacttcc   Aagccgcgca   Gctcccgtcc   Gccccgcccc   720     Gccccgcccc   Ggctcgggac   Aaagcccgga   Gcccgcgccg   Ggagacggag   Ggcggctccc   780     Gcgcgagcca   Cgctcccccg   Tgggcgcgag   Actccgccca   Gctgccgaaa   Gcccgcgccc   840     Caacggcgaa   Gcagccgcgc   Cggtccgccc   Cgattcccca   Tgacgtcacc   Ggcggcggca   900     Ggccccgcct   Ccaggccccg   Gcggcaggcc   Gcatgacgtc   Accgaggccc   Cacccctccg   960     Gagcgagttc   Ggtcctggcg   Ttcatttcat   Tcctgtcctc   Attccgaaca   Ttcttagcat   1020     Cgctcgcgcc   Gcgccgcgcc   Gcctgagccg   Agccgagcct   Ctgctgccgc   Cgccgcggcc   1080     Ccgccgcccg   Ccgcgggcgc   Ccacacaagca   Ctttgcagac   Tcgcttccac   Cctgcgggcc   1140     Attccgcgcg   Gcggggcccg   Ggcccggggc   Ggccgcgtcc   Aggcacaggc   Catgcagtga   1200     Cgccccccca   Cccctccacc   Tttgcccgga   Gcgcgggcag   Cagcccagcg   Cgccagccgg   1260     Cccgggggca   Ggagcggtgc   Taggcagggg   Tggggtggcc   Gggcccaggg   Accgggagcc   1320     Ggggagggag   Ccgggcaccg   Agcagagggc   Gggggaagcg   Gcgccgaagt   Ttgcctcgga   1380     Ctcgccgggc   Gctgcggtgg   Ctccctgggc   Cgaggtaagt   Tggcgcgcgg   Ggcggatgct   1440     Ggggtgcggg   Gggcgcacgg   Ggcagcgggg   Ggccggcggc   Gcgtccctcg   Cgggccgctc   1500     Tttctttgcg   Ggctctgctt   Tgtgtgcgac   Ggcgggcggg   Cacgcggagg   Gccgcggccg   1560     Ggcccccaca   Cccgcctccc   Cgcgccccct   Cggaggtgag   Cggccgggcg   Ccgccgcgcg   1620     Acttgccagg   Acgccaagtt   Gggccgcgcg   Ctgggagccc   Gcgcggcaac   Aggcggcccc   1680     Cggccggccg   Cgccgcgccc   Cccgcgcgcc   Ccctctcccg   Ccgcctgcac   Gcgcacacac   1740     Gcacacaccc   Tcgggcgcct   Tggacggggt   Gcgctgggga   Gccagaagtt   Cggagcgagc   1800     Gcgggcgggc   Agagccgccg   Cctcggagcc   Cggagccggc   Ctgcaccccc   Ctgctttcgc   1860     Cgccgccccc   Cggcgccggg   Tacccccgag   Gccggcccgg   Gtctgcgcag   Acttgtgccg   1920     Ctggcggggg   Gttcgctcct   Tcttctcaaa   Gatgaaaaag   Ggcacggtcg   Tctttgccgc   1980     Ttctccagga   Ctgttgctgc   2000       <210>   70   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   TMEM101     <400>   70   Aaaatttatt   Tttagaaaac   Taggtactct   Ccaaggtcct   Ttgtacccca   Tgagtctgag   60     Attactaaac   Taacagttta   Aaagattctg   Ggaaccaggt   Gaccggggtt   Ctggtcccac   120     Cagtatcctg   Tattgtggct   Ttgggaaagt   Ctgtttccca   Tctctagacc   Tcagtttcca   180     Cactttgaag   Aggaaggttg   Tgtggtctct   Aagatccatt   Tctgcgctct   Gtaatctcca   240     Taagccaagg   Ggttcgaacc   Tcccaggctt   Cacactgtgc   Agctggccag   Caccattcat   300     Cgcccaccaa   Cagccctggg   Cattggcctc   Tgattccccg   Tcacccagag   Ggaagaccct   360     Tttggggccg   Aggcgctcac   Cttcagccag   Tccccgtagt   Ggacgtagcc   Cccgatgtag   420     Gcggcgtagg   Tgctaatggc   Caattggagt   Gcggccccca   Gcgcgaacca   Gcgccgcttc   480     Acgccaaagg   Acatgaaact   Agcgcacagc   Acggctgccc   Ccatgtcgaa   Atacaggtaa   540     Ggcactggga   Tgtcgggctt   Cctgcgagcc   Gggagtgggg   Aagcaacgag   Gacagaatga   600     Agcggtgggg   Gaagaagctt   Gagacccctt   Gagttcccac   Aggctccact   Gctcccccaa   660     Accagactcc   Cctcccatgg   Gcaggaccgc   Cctaccadat   Ttggtccgac   Acccagacca   720     Gaacccctcc   Cagggaggtc   Ccaattcctc   Ccagttcaag   Ggtcccgact   Tctagccccc   780     Aatttcttgc   Ccacatcacc   Gccccctgcc   Gcgtttagcg   Gctgcgtagg   Cctgctcacc   840     Ggcgtgcctc   Agccctctca   Gcgtacagca   Tgagctggct   Gaagcagccc   Caaaaggggc   900     Agcgtgtgag   Cagcaccgaa   Cccaactgca   Tgatcagctg   Caacatccac   Cgtctcgaac   960     Ctatcttcga   Cgccatcttg   Ggaaagggca   Gtccgctgcg   Gcctcacccc   Agtcagagaa   1020     Gcaggcgcgg   Ggatgggaca   Cgcagcttcc   Gggtcaagcg   Ctttttcttt   Ttcctcccgg   1080     Aaacaacggt   Gtcattctct   Agttccggat   Ctaaggtgac   Ccagttgcga   Agtccagcct   1140     Tctcgtctgc   Tcatggagcc   Ttcagggcca   Tatttgtccc   Tgcgaatttg   Aaaactagac   1200     Tagaggaagg   Aacagtgggt   Tcaggatagc   Agaagtcttg   Gaccgtagta   Tgatgtattg   1260     Aagcaaactg   Gtctttgaat   Gcagcccgat   Cagggcccta   Atcctgattc   Caaccctgtg   1320     Tgattctggg   Cacatcacct   Aaactttatg   Agactcatca   Tgaaatgggg   Ataattacac   1380     Ctacctcaga   Gttgtgaact   Ttttttttct   Tttttttttg   Ttttgttttg   Tttttgagac   1440     Ggagtctcac   Tctgtcgcct   Aggctggagt   Gcaatggcac   Gatcttggct   Cactgtaacc   1500     Tccgcaacct   Gggttcaagc   Gattctcctg   Cctcagcctc   Ctgagtagct   Gagactacag   1560     Gctctcgcca   Ccacgcccgg   Ctaatttttt   Gttattttag   Tagagacgga   Gtttcaccgt   1620     Cttagccagg   Atggtctcga   Tctcctgact   Tcgtgatccg   Cccgcctcgg   Cctcccaaag   1680     Tgctgggatt   Acaggcatga   Gccaccgcgc   Caggccagag   Ttgtgaactt   Taaatgtgac   1740     Aaggtcggtc   Ctagtacata   Gtagtggttc   Aataaatgat   Acacataacg   Caccagagga   1800     Aacccccgtt   Tctgttaaga   Tcaaagtaag   Gggtcctcct   Ggctcaaagt   Cacctctttg   1860     Ggtttgcctt   Ttgcctgtgc   Cctgagagaa   Aaaggagatc   Tgaacatctg   Ggacatctca   1920     Agtcagtcca   Tttctccagc   Tgccatgctc   Ccgctgtaac   Ccaaattgtc   Atactttgtc   1980     Agtttaattg   Cagcagacat   2000       <210>   71   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   TRIM61     <400>   71   Ggaagcaatt   Ctcaaatctt   Accttgcatt   Ataatcacct   Ggaggtcttg   Gtaaaagatt   60     Gcctgggcca   Catccccagt   Ttctgactca   Gtagggctgg   Ttttttccta   Agttcccaga   120     Tgatgctgct   Ggcctgcgga   Ctgtactttg   Tgaacctatg   Ctttaaggaa   Aacaaagcaa   180     Aaagatccat   Taagatctag   Tccaagtttt   Ttgcctagct   Cccatcatgt   Cacatatcac   240     Agttatgtga   Ttttacagct   Actctgcaat   Tctttaccta   Actgtaaaaa   Cccctcacca   300     Ggcagcaagc   Ttcttggtgg   Caatacgtct   Ctagcttgtt   Tgaggaataa   Ataaaacctg   360     Tggtagattc   Caagctctca   Gtttcaacca   Tcatcatact   Ggctgattct   Taacatgcct   420     Gcacctaaag   Cgcctcatct   Acaaagttga   Aatgataatt   Cgtacctgta   Agaccttgt   480     Gaggattaca   Ggatgcttac   Ataggtcgag   Ggtgcagacg   Acgtaggctg   Gtgggttctc   540     Aactggcagc   Taccacttcg   Ctcccttaac   Tccccaaccc   Ccactcccaa   Acacgtacat   600     Taactctttg   Aagataacat   Agccacttca   Taaaccctaa   Ttcagatcat   Aacatttaaa   660     Gcttaattga   Tacaggctca   Acacccccat   Tctaactcta   Caatcctgaa   Tttttcacaa   720     Gagctacgcc   Agacactaag   Gagatccagt   Cgtgggcagg   Cagcgacccg   Gaggtttagg   780     Cacagagaat   Gttcaagaag   Cccctgtcca   Gttaagcctc   Ctggcgaggc   Ccttctgggc   840     Ctttcctgcg   Gccttcccag   Ctcacctgga   Gcagacggat   Cagcaaatcc   Ggccaaagaa   900     Tactcaggac   Ccaccgagcc   Cccgcgagga   Aggactcata   Ccccaacccc   Accaagtggg   960     Ctgcttcctg   Cctggggctc   Agcctgcgcg   Gtggttggca   Gttgccccgg   Aagtgggcgg   1020     Gaaggacctg   Cgcatgctct   Gtgaccctgg   Gtgcagggat   Tgtgtgaaga   Ttgagagctg   1080     Ggggcgccct   Cttccgtgat   Cagggccccg   Ttggccccaa   Ctggcattta   Attcccctgg   1140     Ctgtcttttc   Ggattcttat   Cactttttat   Gtatatgagt   Aaacttgagg   Gtccaagtaa   1200     Gtctgcaagt   Tggttttaaa   Agcttcacca   Gcacagcgtc   Ccctcccaga   Tggtgaggga   1260     Gtggagagct   Ttgcagggtc   Aactgcttcc   Cgtagcctgg   Ggtcgcaggg   Tggagtcgtt   1320     Gagcactccc   Tatgcttgaa   Agaggaatag   Aagcccttt   Ggattagttt   Gcatctcagt   1380     Gggtgagtgg   Gtggatctct   Cccaccctgt   Gggattgtgc   Cccaccctta   Gaactcaggt   1440     Ttcctgagg   Aagtgacatt   Tcaggcggaa   Tttgagggat   Gaagaggcat   Tcgttggatc   1500     Aattccacgg   Tcaaagtctt   Caaggctgga   Agaagagcca   Atgtggagcc   Tctcaacttt   1560     Aaagaattta   Gtacaggccg   Ggcatagtgg   Ctcacacctg   Taatccaagc   Actttcagag   1620     Gcagaggtgg   Gaggatcgct   Tgaggccagg   Agttcaggac   Aagcctaggt   Aacattgcca   1680     Gaccctgcgt   Ctacaaaata   Ttttagaaat   Gatttttttt   Tcttttaata   Agagacggaa   1740     Tctctctttc   Gcccaggctg   Gagtgcagtg   Gcgcgatctt   Ggctctctgc   Aacctctgcc   1800     Tcccagtttc   Aagcaattct   Cctgcctctg   Tctcccgagt   Agctgggtct   Ataggcgcac   1860     Gccgccacgc   Ctggctaatt   Ttttgttgtt   Gttattttag   Tagagacggg   Gtttcatcgt   1920     Gttgcccagg   Ctggattcga   Actcctgaga   Tcaggcaatc   Cgcccgcctc   Ggcctcccaa   1980     Aagtgccagg   Attacaggcg   2000       <210>   72   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   UCKL1     <400>   72   Cggcgtcagg   Ctgagtctgc   Accgagccca   Gccccactac   Cttctccaaa   Gctggtctgt   60     Ctcagagcca   Aggacaaagc   Ctcaccccac   Ggttcacaag   Cagcacccct   Tgacaggaaa   120     Gttggccggg   Tgtggtggct   Carchccttga   Acagtccttt   Ggaggctgca   Gtgggaggac   180     Tgcttgaggt   Cagcagttcg   Tgaccagcct   Gggcaacatg   Gtgagacggt   Ctccacacaa   240     Aaaactttag   Aatattaaaa   Ataaataaaa   Acagaggaga   Aagttgcaca   Gcaaacctca   300     Cttcctgtgc   Acagatggac   Aggagtgctt   Ctggccacaa   Caacaaaagg   Ttaattccaa   360     Cccggagggt   Tccaagccgt   Aaccaacaca   Agagagacgc   Gcccagacca   Acagcctcaa   420     Gcaaaatggc   Accttcgacc   Ctgggctctg   Cccggtgccc   Gagagcacct   Gccagcctgt   480     Ttgattcctg   Atatccacag   Acatgcacca   Aacacaggtc   Tgagtggcca   Ggaccacagc   540     Acaagtgggt   Gcccctcacg   Gcagagacct   Ccagtcgaga   Ctcacctgcc   Ttctgctcca   600     Agggcccggc   Accctgagat   Cctgatgcca   Gggtaagctg   Gggggctgct   Catggtcgag   660     Gacacgggtg   Ggtgctcctg   Aacagcagag   Tggccccagg   Ggtggatgcg   Tgggggctca   720     Ggcgcaggca   Gccgtggggg   Acatcaccac   Ctcagaccca   Cagcagtccc   Ctagggcagc   780     Tcaggagctc   Cggccacctg   Aactggccct   Tccatgggca   Ggaccactcc   Tgtgggcagc   840     Acaggtggtg   Cagagccggg   Tggctggggt   Gagacccttg   Gctggcagaa   Gctgcctgcc   900     Aaatgtcagc   Agaggcacag   Cagctaggag   Gcccttgaag   Cctccaccgt   Actgagggaa   960     Cagcactcac   Tgccgtcctc   Agaggccaag   Gccacaggca   Taagaggatc   Acccagctgg   1020     Gggcttgtgt   Atgcctgata   Ttaatagcgc   Tggctttgcc   Tggtgtggcc   Ctgacaatcc   1080     Tcgggccagc   Cctcggtgtg   Aactgccccc   Tcctgtgtgt   Gggctggcac   Attcggccag   1140     Cctaggaccg   Caggcctgcg   Gaggaccact   Gtgcgccgtg   Tgcctgcacc   Cctcctggat   1200     Cccctggaaa   Aagctacagt   Accccggcct   Gcctggggct   Acagagtgaa   Ccccccgcag   1260     Caggacaagg   Atatctgagg   Cgcctcttgg   Ccaggtgtcc   Tgaacgtcag   Tgctgagctg   1320     Ggcaccccat   Ccctagcccc   Agaggtcttc   Cgacaggcat   Aaacaaatct   Gaaactccac   1380     Cctctggcac   Catctgaaaa   Taactgcctt   Gccctacccc   Cactcacggg   Ggatcctgca   1440     Gggacctgca   Gccacccagg   Gctcaccacc   Cagggctcag   Cagagcacag   Gggacacagc   1500     Cacctccccg   Cccagggctc   Agcagggcac   Aggggacaca   Gccacctccc   Cgcccagggc   1560     Tcagcagggc   Acaggggaca   Cagccacctc   Cccgcccagg   Gctcagcagg   Gcacagggga   1620     Cacagccacc   Tccccgccca   Cagaaacagg   Gtttcggccc   Caccctccgc   Agagtcagtc   1680     Aaggatgtgc   Acagagagat   Cctggcagcc   Ctaagctctc   Tcccaggggc   Agacaggtca   1740     Gccatgggtg   Tcagcttcct   Cctaccatgg   Gtttctcttg   Gagcttctag   Tactgaggca   1800     Ggggctgcca   Gaagctcagg   Gaaaagggaa   Gactccacat   Ggaggtcata   Ctcctcaata   1860     Gtaggccact   Cctgggagct   Gcctcagagg   Caggaccggc   Ccatctgtct   Gtgtccacag   1920     Gtgcttcctc   Tcctcattct   Gctcccagga   Ggcggctaca   Tccctcactt   Gggaagtggg   1980     Caggagacag   Cccagggtcg   2000       <210>   73   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   VWC2     <400>   73   Atcctccatc   Cagccctgtt   Ggttgtgtat   Gtgttggagg   Gggtggaggg   Gcagccttct   60     Caggctttca   Aggaggdcct   Cctagcacct   Cagctaagat   Ttgtttgtct   Atactattaa   120     Aagatagaca   Taactgtgtc   Ccaaaccagc   Ctccccagtt   Cccaccagcc   Agagcgcctg   180     Accttgcagg   Gaagcttatc   Tgtttaccgt   Ccgagcactt   Tcagggattc   Taaaatgccg   240     Tgagtgggaa   Ccactgccat   Gggccatttc   Catgaaaatt   Caatttcggg   Gattaatttg   300     Aacaggtact   Attgacgttt   Tctcgtttac   Acaagatcaa   Agagtaaaaa   Caaccgggcc   360     Tctgcttaac   Agttgaggat   Tctagcaaag   Ttaggaaaca   Ggtttctatt   Tgtagtagaa   420     Gagagagcag   Gcagaaagag   Gaagatggga   Gcggggagag   Attggcagag   Attcagaaag   480     Ttcgcgcttg   Agatttttac   Gtttcttact   Cgtaaacgtc   Tatttctctg   Ggtttctgaa   540     Tgcaaagacg   Gagaagtctc   Aacagtctgc   Taaactaaca   Cggccttcga   Atcccaatct   600     Gaacacagta   Gctgaaacaa   Gctgtccaca   Aagaggaaag   Cgagaggggg   Ccaattagga   660     Aggaagaaat   Taaagaaaag   Agaaaagcca   Agatgaaagg   Tccagcgcaa   Agtgaatgac   720     Tcgactggag   Aatggcagcc   Ctggcagggt   Ctgcggccgg   Ctgcggaggt   Ggggacgcgg   780     Ccgcgcggac   Gagtgacagg   Ttggtccggc   Gcagcaaagg   Gagggggtgc   Ggcggtaggg   840     Cctctccggg   Ggcagcgcga   Gggcctcccc   Cggggcagcg   Cgggccaagg   Cggggcctcc   900     Agagcggggg   Cagcagagga   Gggagcggaa   Cgggagccgg   Gcggaggcgg   Ctgcggcagg   960     Gggaggcggg   Aggcgggcgc   Gctagctccc   Atgctggcct   Cggtgccact   Cgcgcgccgg   1020     Ccgcgctccg   Ggcttctctt   Ttccctccga   Cgcgccacgg   Ctgcccagac   Attccggctg   1080     Cggggtctgg   Agagctcccc   Gaacccctcc   Gcggagagga   Gcgaggcggc   Gccagggtgg   1140     Cccccggggc   Gcgcttggtc   Tcggagaagc   Ggggacgagg   Ccggaggatg   Agcgactgag   1200     Ggcgacgcgg   Gcactgacgc   Gagttggggc   Cgcgactacc   Ggcagctgac   Agcgcgatga   1260     Gcgactcccc   Agagacgccc   Tagcccggtg   Tgcgcgccag   Gcggagcgcg   Caggtggggc   1320     Tgggctgtta   Gtggtccgcc   Ccacgcgggt   Cgccggccgg   Cccaggatgg   Gcgctggcaa   1380     Cccgggcccg   Cgcccgccgc   Tgctacccct   Gcgcccgctg   Cgagcccggc   Gtccggcccg   1440     Cgccctgcgc   Tcatgtatgt   Aggtttggcg   Ccggtcttca   Gggctgaggg   Tgcatgctgg   1500     Gtgtccccgc   Gcggccggac   Gcgctccagc   Tgggttcagc   Cgctcagctg   Ctccggagga   1560     Accccctccc   Ccgcccaagt   Ttgtgaatat   Gggcgcttcg   Cccagtgttg   Aggtcggcag   1620     Ggaccgggca   Gggggtcagc   Agggccgggc   Acgtccggag   Ccctcaggga   Ggagggctga   1680     Gggggagggg   Acagacgcac   Cggagtgcgc   Agaggtgggg   Cgttcgggga   Gtgaggcgga   1740     Gagaggctgg   Attgccggtg   Tcctgcggcg   Tctcgggctc   Tcccagcccc   Tttgggcggc   1800     Agaaactttg   Gaatccagaa   Aggctggccg   Ggatccagcg   Agtaggaggg   Tctcgcgccc   1860     Actctgcgcc   Ctggggcccc   Agcctcccgc   Actgcacacc   Ttggtgctgc   Ccgggcgctt   1920     Ctgctccgca   Gccaggacac   Tacaagactg   Agcgctgcgg   Ccggcgacct   Ggctcccaag   1980     Gctcggaggg   Gcgggccggc   2000       <210>   74   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   WDR69     <400>   74   Gctgtttact   Gaaaatttca   Tataatttta   Aatttagaaa   Taaaaacttc   Acagatggaa   60     Ttaaatttca   Tataattttc   Agtaaacagc   Cagtaactgt   Aaaagtaaag   Gtaattttta   120     Agattacatt   Ttactaagtg   Aagtaaaata   Agtgagtcaa   Tctagagaca   Ttttaagaac   180     Ttaaaactta   Ggtatggatc   Tctggaagag   Gtaaggagag   Atatggctca   Tagttgcgca   240     Gataacacag   Gaatgactca   Agtttgagaa   Attccagttg   Aggccaaatt   Ccttaaagga   300     Aattgacaag   Ctggttggct   Gactctgtct   Ctccgcaggc   Tttctcatgg   Aaacgtggca   360     Ggcaaacaac   Gatgctggca   Agaaattgga   Caagccgcat   Gaaggcctgg   Agaggtttaa   420     Gcccaggttg   Agagcacagg   Tgtaggcttt   Ctggtgtagg   Ttccgacgca   Cctgccttcc   480     Attcccgcct   Atccatttag   Gctgcgacct   Ctggtagttc   Tccactttct   Ctaattctga   540     Gttacttcat   Ccttaagaag   Tggtgcataa   Ctcacacctt   Gttaggattg   Tatgagtatg   600     Tgtgcataca   Ccgtttaaag   Caatgtaggg   Cacagagtca   Ggaaatgcaa   Aatattaagt   660     Tgaggtcatt   Tttcttttgg   Gaggacaagg   Acagggcacg   Ggctggggcc   Ctagagtagt   720     Aattagcgat   Gggcttttcc   Tcccagcctt   Ccttttggga   Aacgcagtgt   Gctaaaaaag   780     Tgcatgcagc   Ccaggctgtg   Gcctaggccg   Tcggttcccg   Gccatgccta   Gctcctctga   840     Ggtcgccctt   Agtgaggaca   Cgaggtgccc   Tcacctcttt   Cactctagac   Acctccagaa   900     Cactcgcccc   Ccgcgcgccg   Gagccccggg   Tcgccaccaa   Ccgcccgcgg   Agccagacct   960     Cccagctctg   Cgccccagga   Ccgcgcggtg   Caacctgcgc   Atgcgcaccc   Gcgtcccgct   1020     Gctgtttagc   Cgtttccaag   Gctacgaagc   Ccatcggccg   Gggataagag   Agcaagaaaa   1080     Tgaagctcaa   Gaggctcctg   Ctccggtatt   Acccgccagg   Tacgcaccag   Cccggccccg   1140     Tcatccccac   Gtgggaccct   Gggctcccag   Actgggaggg   Tttggggcgg   Aggagggggc   1200     Agccactgaa   Aggcggcggg   Gtccccaggt   Ggggcaggaa   Gtcgggcact   Tcccaacctg   1260     Tgcccctcat   Tccttcagat   Gctggactct   Tcctcaaaac   Attacaatt   Actcttttag   1320     Gaatttaaag   Agtttagctt   Gactgtgcat   Gtcagtctgt   Ctgcatttat   Tgagtgccta   1380     Ctgcgtacac   Gctttgtgct   Ctctgctatg   Gacctttaaa   Gaagttcata   Gtgcttgatt   1440     Tcaatgagtg   Aagtaattat   Gaaataaatt   Acttaactat   Tacttagtaa   Cataagcaat   1500     Acattaatta   Cctaatcctt   Gcctaactct   Aattttaggt   Gaggacatgg   Tcacctttaa   1560     Agaatatagg   Acacccattg   Atcacccagc   Ttcttaggga   Cagaaatagg   Agtgcaattc   1620     Ttgggttcta   Attcagaact   Cgtcttctga   Attagaaaca   Tctgcaaaaa   Aaaaaaaaaa   1680     Aagaaaaaaa   Gagaaaaaat   Ctgcaaaaca   Taccacaagg   Cagaagataa   Ccaaatacac   1740     Ttgcccaatg   Aagtttggat   Aggaagtgtc   Ataaagattt   Caaaggaggg   Taagatactt   1800     Tggaccggtt   Ttgttaagaa   Tagctttatg   Aggggtggga   Cttgaatttc   Aggttgaata   1860     Tctcactttt   Ccctgcaaca   Catccaactg   Cttggtcaac   Atcgccgatg   Aggtatcgca   1920     Tagagatctc   Atgatttctt   Ttttccagtc   Ccatcccaat   Cctgctgctt   Cctcaaactg   1980     Tgccctgcca   Gtagaaggca   2000       <210>   75   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   WDR86     <400>   75   Gcccgactcc   Tgcggaggca   Cgcggcgagg   Ggagggtgaa   Ggaccctagc   Tccccgctgc   60     Ctccagccctc   Tgggcccgcg   Aacccagggc   Gctgcggggg   Gcggcccact   Cgggacctcc   120     Gccctgggta   Gagtcctggg   Cgcgcgggca   Gagagaaccc   Ccttcccagc   Accgctcgga   180     Ggatccacac   Cccaccgggc   Gaacaaggca   Gctgcgtctc   Tggtgcacaa   Ggagcccccc   240     Gcctcctctc   Gcgcccacgg   Ggctggggcg   Gggagaggaa   Cacgggaagc   Cgagcgcccc   300     Gcgccctccc   Cggccgagcg   Cggaacaata   Cggtccagcc   Tggctcctcc   Tcagagacca   360     Cccctcaccc   Gatcccctcc   Cacttctcgg   Gctgcgcccc   Agcccccacc   Ccgcgcgcct   420     Gcagcctccc   Cccttcgtcg   Ctgtgcgggt   Ccgggggacg   Gctccacgtg   Cgaccctcct   480     Agctgcccgg   Gctgcgcctc   Tgggctctgg   Cctctgccac   Ctccgccgcc   Gccgcctggg   540     Tcccctgagc   Caagggccgg   Gacgagggag   Ggggaggcgg   Acaaagggtc   Ggggtcgggg   600     Agaatcgcgc   Gccgggaact   Catttggggc   Gcagctccac   Cgacccctcg   Gctactcgcc   660     Tccaccaggc   Aagccaggtc   Ctcccatgct   Ctgagcccta   Aggactctgc   Ccgaggggct   720     Ctcggggact   Tgggggcggt   Ccccacatagg   Agggtgcgac   Agggaaagcc   Ccgagtccgc   780     Cctccctggg   Aaatcacgcg   Cacacccagg   Attctacttt   Ggtctggccg   Gagtggggat   840     Gaggtgcgag   Ccgctgcggg   Gtcggtggag   Ccgggatgtc   Aagttcacct   Tccagccgcc   900     Gcgggctccc   Tcggcctggg   Gcgcctctaa   Tggaccccgg   Ggtcggcctg   Agccctcccg   960     Gaggccccgg   Cggctggttt   Ccattagggc   Agttccggcg   Ccgacttcgc   Tggggacggg   1020     Gaaggtgacc   Cccctactcg   Gatcccccag   Gtcctaaagg   Tagcaggatt   Tccagaacgc   1080     Tccagggctc   Tctcaggagc   Ctagggagaa   Gggcaaggaa   Ggggcgtctt   Tggcgagcta   1140     Gcccgcaatg   Ggacgaccag   Tactgcacgc   Tctgctctat   Ccagactcca   Aaagaaaacc   1200     Ccatcgtggg   Gtgtcccagg   Ccgttgggtc   Gtttataccc   Agagggccct   Aaccagagaa   1260     Atccgttctt   Ttccctcaaa   Acttgtaaag   Cagctggcgc   Ctcagcttaa   Ggagcgtggc   1320     Ccttccttag   Caggtggtgg   Agagaggggc   Agtggaggag   Cgttaggacg   Agatttgggg   1380     Tcatccagcc   Ggagagaggg   Aggccgaaag   Gagagacgtt   Ttcaggaggt   Ggaggcttca   1440     Gcatttggat   Gcctgcgagg   Cgggagaggc   Cggggagcct   Gtcttgtgct   Gagaggctgg   1500     Gtagactgtt   Ttgtccccta   Caggctgatc   Accagttcct   Cttaggaacc   Ggtgaacctc   1560     Agggggccca   Ttgcacatcc   Aggtgtgaaa   Ctgcggtgtg   Gcctccaggt   Gaggacagac   1620     Tcggtatagt   Ggggatcttg   Ggcaggccct   Gcggctgcag   Cccttgggga   Aggtgaatgt   1680     Gaggaccatg   Gaggctggga   Gggtttatcc   Ggagaagtgc   Cagaggaaac   Ccaaactttc   1740     Tgggcagagg   Ggccaaggag   Aaccaggcat   Cgactctttt   Ggaaactaag   Aggggagggg   1800     Tttgaaagca   Gtttgggagc   Tggggacaga   Tcgtaggttg   Ggcgagcttg   Cctggtcgtg   1860     Ggccagagga   Aagaaccacc   Aggagaaaag   Cttaactttc   Aaggaggtca   Cccaggattc   1920     Ctgagcaagg   Tggcacccat   Gcactctggt   Tcctctcctc   Tgcagccaac   Acaagccatc   1980     Agccccatgc   Tcagctccca   2000       <210>   76   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ZDHHC19     <400>   76   Gagaagagaa   Agaaagaaag   Aaaagagaag   Agaagaaaga   Gtgagcgagg   Gccagagcaa   60     Tgaagacgtg   Gggtgaaggg   Gtccagaggc   Tggaggaggg   Tcagtaggaa   Gagcacttta   120     Ggaatccccc   Ctgcaggttc   Ccagcccttg   Agtgacacct   Ccttttccca   Gggggctgat   180     Gcctcacctt   Gatgtaagat   Gccagggtct   Gagaagttga   Gtgaaacaag   Actgaagaag   240     Gtaaggacaa   Agagggagcc   Tgtgataaca   Ggaaaggccc   Actccccgtt   Ctgagccagc   300     Cacctgcaac   Tgagaccaga   Ggcaggctcg   Gtcctgagca   Ggggcagccc   Aaagcccccg   360     Gcccaaggcc   Tgtggcttgc   Tcaggtcagg   Acccacagac   Cttcaagcca   Gatctaaaaa   420     Tccaggctcc   Aaatacccag   Gcagactcat   Aatggctcca   Ccaaatgtca   Ccagcatgac   480     Cagccaccca   Aagctcccaa   Aatgcacagg   Cacccttgac   Ctctgcgcct   Ttgcacgtcg   540     Gttcctggaa   Cagaatatcc   Ccttttccct   Gcccgcaccc   Ttgacctctg   Cacctttgca   600     Cgtcggttcc   Ctcgaacaga   Atatcccctt   Ttccctgacc   Tctcccccgg   Tcttctgcac   660     Tcccctgcct   Ccatcctatc   Atcttctgtt   Tccctggctg   Tctctttgtg   Ggaaacctaa   720     Cggcttgcct   Ggaaaactca   Cgggaatgcg   Aagaagaggc   Cactgaaaaa   Gaccagcagc   780     Accacattga   Aggcagcaaa   Gaggctaggg   Aggaaccagg   Gacgtgggac   Cagaggcagg   840     Ggatggggct   Ccttcaccag   Cggcgtggca   Tccgttaaga   Gtgtcatggc   Tgggcctcct   900     Tcgcctccag   Gggaggtcag   Agccaccagg   Cttcctcccc   Cagcccagct   Tccagagctc   960     Catggccacg   Gcagcctcag   Agccgcagcc   Cagggtgaaa   Ggaaagaagg   Cccagtgtga   1020     Catcacagag   Gctgggggac   Ctcagcagaa   Ctgtctgcag   Ccctgctcta   Gctgcctccg   1080     Gtgacaggca   Cttccaacag   Caaaccccac   Ccccaccccg   Acatgtgctg   Gggaaccggg   1140     Agttcctgcc   Cctgagaggc   Tgatgttgtt   Ggagaaaata   Tgacctggag   Aaacacatgg   1200     Gaagaaagtt   Ggtaattttc   Agccggcgct   Gtaatccctg   Taatcccagc   Actgtgggag   1260     Accgaggcag   Gcagatcact   Cgaggtcagg   Agttcgagac   Cagcctggcc   Aacatggtga   1320     Aaccccatct   Ccactaaaca   Tacaaaacta   Gccaggagtg   Gtggtgcacg   Cctgtagtcc   1380     Cagctactca   Gaaggctgag   Gcaggagaat   Cacttgaacc   Tggaaggtgg   Acgttgcagc   1440     Gagccaagat   Cgcgccattg   Cactccaacc   Tgggtggcag   Agtaaactcc   Atctcaaaaa   1500     Aaaaaaaaaa   Aaaagaaaga   Aagttgctgg   Gtttttttgt   Tggtttgttt   Tgtttgtttg   1560     Tttgtttttg   Agatagtttc   Gctcttgttg   Cccaggctgg   Agtgtaatgg   Cgcaatctcg   1620     Gctcactgca   Acctctgcct   Cctgggttca   Agcggttctc   Ctgcctcagc   Ctcccaagta   1680     Gctgggatta   Caggcatgca   Tcaccatgcc   Cggctcattt   Tgtattttgt   Agtagagacg   1740     Gggtttagtc   Atgttggcca   Ggctggtctc   Gaactcctga   Ccacaggtga   Tccacccacc   1800     Tcagcctcct   Aaagtgctgg   Gattacaagc   Atgagccata   Ttaaacttcc   Tttataaaag   1860     Gcctcaaaaa   Gaagaaactg   Aggcagaaat   Ttaaaaataa   Atatgcattc   Attcactcca   1920     Agacagataa   Caagcaaggc   Aaaagttaaa   Aagaaaagaa   Caagttttcc   Tctgcccagc   1980     Aagctcactt   Caaggacagt   2000       <210>   77   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ZNF300     <400>   77   Aggaacacaa   Gagaacacat   Atactcatct   Ctggatatcc   Cgcagatgct   Caataaatgt   60     Ctcttgaata   Aaatataaaa   Tgatttaaat   Aaacttagaa   Agtggagaac   Tgaaatcaaa   120     Cttttaatta   Tgattttatc   Agttttgatt   Tgtttggtct   Tgttttaaaa   Tgaccatttg   180     Atgggggtac   Catcagaaat   Gcttagtggg   Caatggtaga   Ctaagaaaag   Atgtgaaaag   240     Gggttgacct   Ttaagaactc   Aaacagttgc   Ctatgacctg   Tggaaattta   Acgttaagta   300     Aaggccttcc   Ccagtaaaat   Gtggctgacc   Accatgacac   Cgtggcccca   Ttactgtccc   360     Catctaaatc   Tcggaattct   Caggcctagt   Aatcatatac   Cctactgaac   Tcccccatgt   420     Ccatcacatc   Actgaacaca   Tggacgcccc   Catcatttag   Tccatagcct   Cccatcactg   480     Attcctcaga   Gtcccctaaa   Tcactgaacc   Cagttaaacc   Caccagtcag   Tccacctgca   540     Agccattcct   Gacctaatag   Acaccccctc   Acctctcact   Tccctgttac   Taatcacatc   600     Tcggactccc   Acataaatcc   Aacattaatc   Ccaccctactt   Cccccaccag   Tgatttcata   660     Aacctcctac   Cactgaccct   Cacgggctcc   Tctcctccca   Ttaccaatcc   Cacagactca   720     Cccttcaccg   Cacacatccc   Gcctctgact   Cccagctcga   Tttacaggtc   Ccaaaaccac   780     Catcaccgct   Taatgggaac   Cgctgtcaca   Tccctattgg   Caaactctcc   Tgcttcctgt   840     Ccgcgagcac   Cacaccgggc   Tcccgaggct   Gcgccgttcc   Gtactgggcg   Gttttgcccg   900     Ttccgcatct   Tcagaggctt   Tgttcaggaa   Gcaacatggc   Tgctccctgg   Agctgtttcc   960     Gcatggggcc   Gccatcttga   Gagcccggtc   Gtcttcgtac   Tagcggagga   Ttcgcccagt   1020     Gctgagcccg   Agaatgggct   Gtaccacagc   Ggcagcgaag   Ggaggggaag   Gcgacggaaa   1080     Ggaggcctgc   Gaaaggagca   Ttaaggagca   Cacttttgca   Gaaagatttt   Acaaggggga   1140     Ttgaagagga   Agttggagtg   Aaccttcctc   Tattggaagc   Atgcttctga   Cgaaagggga   1200     Ggaattttag   Atggtaccat   Ggacgtgttt   Gtgaatggta   Cagccccatg   Ccgggagatt   1260     Cgactgctca   Gaggggaagc   Gtggaatggt   Gcggtcctct   Ccagggagat   Ttcactgtgg   1320     Gagagaggga   Caaaatctgg   Gggctgaaca   Atcattgtgt   Actgtaatta   Tgccaataac   1380     Aacggtaagg   Aatccttata   Agggaatttg   Atattgcagt   Aataagtaat   Aagaggtcga   1440     Ctgaaggaaa   Aagggaaatt   Aagagcaggg   Aagaggagac   Tgaggcacaa   Agagagggaa   1500     Gtgagaagca   Gagaatcaga   Gagaaaatgg   Gggaaatggg   Galacaaggag   Ccaggctaga   1560     Aaggaggaga   Gacgggagac   Tgaagagaaa   Aaaatagaca   Taggaataga   Aggtggpatc   1620     Taaggggtag   Agcgtggtag   Acagacagat   Tgagacagaa   Aagagacttg   Aaaattggaa   1680     Cagacataag   Ggagagactg   Agaaggttag   Atttcagaaa   Caacaacaac   Aacatgattt   1740     Tttaaaaatg   Aaccagccaa   Agagaatact   Aaaattgtta   Tcttaaccct   Tagaccttac   1800     Atcaagcttt   Aaaaaagcaa   Aatgcatgtt   Cacagaccaa   Tgtttcattt   Gtataaatga   1860     Atacaatttt   Gaatcataat   Tttcacacga   Gtcatgcttt   Ttgatatgtt   Atgaaatagg   1920     Cagcaatttt   Acatttagca   Atttatttct   Catgtcaaaa   Caaatgcact   Tagataagaa   1980     Gacaatgtat   Tcagaaagaa   2000       <210>   78   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ZNF334     <400>   78   Tttagccact   Tgagatgaca   Gaatccagag   Agaatgaatg   Aaagtgcttt   Aaggtgtttg   60     Tctttttgac   Agtttggttt   Cccttagctg   Cagtttcaca   Agaggacctt   Ttactaagaa   120     Acttcttgtg   Gtaggtaacg   Taaatgtggt   Agatgacaaa   Agccctgacc   Tggtactcaa   180     Aggaccagaa   Ttcagttatt   Ggatctgtca   Ctagcaaact   Gcattactga   Aaaaaatatt   240     Tactaagtcg   Taattttaat   Ataagataaa   Ttggttttta   Gtctttcctt   Tacccctatc   300     Gtgtagctct   Gtaaggggta   Aactcagtaa   Atcccaggtg   Aggtgatgaa   Catggttggt   360     Gcagctctga   Ataaacagag   Ggtggagatg   Gtagggaatg   Acatgtatgt   Gtttaggaag   420     Tgatgaagac   Atcatttcct   Tatttataac   Cagtactcct   Tccctccaac   Ccaggactct   480     Cgcagatacc   Tccagtgaag   Tgtcttttcc   Tgtcaaatct   Tgaccctgcc   Cattccagct   540     Cacatccttc   Ttccgaaagt   Tgaactgaac   Tttgctgagc   Tataataatc   Aatggctgca   600     Agactaagtg   Catcagcaga   Agttctggaa   Agaggttcta   Gctacttgga   Tgcgtaaacc   660     Tttcaccttc   Accaagcgcc   Ttcttcgggc   Aaatcagggc   Ctagagaga   Gctcgcccgt   720     Ggcctgcagg   Tcaggagccc   Aatcctgccc   Tggctgcctc   Gcctcccgac   Cacaggaaac   780     Cctccctcca   Aagacaggga   Gagcgcgcgt   Ccaccctccg   Cagacccgag   Gcccgctccg   840     Cccggcccca   Ccgttccctc   Cgacgcccga   Gtgctcagag   Ctcgccgcca   Gcccttccta   900     Taggttgtgg   Gtgcacccgc   Ttcgcctcca   Gttcgcacca   Ggtccaagtc   Tcggcgggac   960     Cagggattca   Cgggctgcag   Gaccctcacc   Cggaagagcc   Tggcgaaccg   Gaagggcgtc   1020     Caggtaaaaa   Acaggaacag   Cacatgcgca   Gaaaggcccc   Cgggccgcct   Ttcccggggc   1080     Tctcccgggc   Cccccgccgg   Ctttccggac   Cacagtcccc   Gaagaggcgt   Gcggccaccg   1140     Ccctaccctg   Agggatcttt   Gaggagcttc   Tgctttaact   Acagagttta   Ggtgactgct   1200     Gtgaatcatc   Aatacgaaaa   Gtaaagtttc   Atatccgttt   Caccgaagtc   Tatagatgag   1260     Aaaggaaaat   Tctgcgaaat   Gaaaatgact   Gctaaagata   Ttccagcaga   Atataatact   1320     Aacgacctgc   Agaaaattc   Tcccaaacag   Gatacaaaat   Cattgctggc   Tttcaatacg   1380     Tgaaggttga   Aaataaatca   Gaatatctct   Gaagaaaatg   Aactattagc   Cgtaacccca   1440     Attcccagag   Atatccgagt   Ttaacattag   Gtgcacattc   Ttctgacagc   Tttacaaaga   1500     Ggaactcata   Taggtctagt   Aatttgttat   Tttttaaatt   Agcaatatag   Ttaatatact   1560     Ttaataccac   Gaattatctc   Atatacattg   Tgagtaatat   Gaagaaatagt   Tttacatcca   1620     Caaggaaaat   Acatacaatc   Atgcatggtt   Taacgatggg   Gatacactct   Gagaaatgtg   1680     Tctttaggca   Atctcgtctt   Tgtgtgaaca   Tcatggaggg   Ttcttacaca   Aatctagaca   1740     Atatagtcta   Ctacacacct   Aggctgtatg   Gtatagccta   Tttctcctag   Gctacaggcc   1800     Tgtgtggcat   Gtcactgtcc   Tgaataccat   Atgcaatggt   Aacacaatgg   Tatttgtgta   1860     Tgtaaacata   Tctaaacata   Gggaaggtgc   Agtaaacgta   Cagtattgta   Atcttatgag   1920     Accacagttg   Tatatgcagt   Acatcgttga   Ctggaacatt   Cttatattat   Gcatgactgt   1980     Atatgaattg   Tatacatatt   2000       <210>   79   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ZNF662     <400>   79   Aatctttatt   Ttcacacttc   Ttaaaaaatt   Taatttcctg   Gcatgttgca   Taatgttagg   60     Taagccattt   Tctctctttg   Ggccttactt   Tcttcaactg   Aaaaactggt   Tcaacattta   120     Ttcattcttt   Tattccgtaa   Gccaaaaata   Aaattcaaag   Ccctctgacc   Atatgaatgg   180     Atctctcctc   Ttggctaagg   Gcattccaaa   Gttaacgtga   Aaaactggtt   Caggccataa   240     Tgggaaggag   Gagttggaca   Tggctcatta   Tgctccccta   Cctttgaaaa   Ttcaggacca   300     Gctgaccagc   Attacatca   Acacagacct   Taagactgat   Agaacagcct   Ctttaagtct   360     Cacagactat   Ccggtagtgt   Gataatgatg   Agaaacattt   Gcagtctatt   Ctctgaagcc   420     Tgctacaggc   Tccatctgca   Tgataaaact   Ttggtctcca   Caagccctta   Tcttaactga   480     Gacatccctt   Tctattgatt   Ctaagtcttt   Atacaataac   Ttaactcttt   Caaccaattg   540     Ccactcagaa   Aatctttgaa   Tccacctatg   Tcctgaaagc   Ctcctcttcc   Agttgtccca   600     Cctttccata   Ccgaaccaac   Gtacatctta   Catgtattaa   Ttgatgtctt   Atgtcttcct   660     Aaaatgtgta   Aaaccaagtt   Gtagcccgac   Cacgttgggc   Acatgttctc   Agpatctct   720     Ggggctgtgg   Cacgggccat   Ggtcactcat   Atttggctca   Ggataaatcc   Cttcaaatat   780     Tttacagttt   Gacttttcgt   Ggacaattct   Acaaatattc   Cttggcagtt   Aaagaaataa   840     Ctccccagga   Ggtgctagac   Atcgggcgca   Tgttagaggc   Acaaagatga   Gaatgttaaa   900     Agacataaaa   Tacaggtctg   Ctctgggaat   Gcaaaaactg   Gtaaaaggag   Agataaaaga   960     Gcaggtgcag   Tctagtgaag   Tacccgctac   Ctcctatcag   Caaatatctg   Tccacctagg   1020     Gtgcagcgag   Ctggagagga   Aggggtggcc   Tagagcgcag   Gggaaggatt   Cctccccagc   1080     Cgcctgcacc   Cccacccccg   Tagcggtccc   Tgggatcgtc   Cgtgtctcca   Ggagaaccgg   1140     Accgctctcc   Cctccctccc   Cgagcgagaa   Aggaggacca   Cagagatgcg   Gcgccctccg   1200     Ccgtcctaga   Gcaaccggag   Cggcccgagc   Cccggcctcc   Cggatgctgg   Ggcctggcgg   1260     Gtgtggagca   Cggggagtcg   Ggcgtggggc   Gggcagggag   Tggagtcggg   Gtcttactcc   1320     Ggtggctgca   Gggcgcaggg   Tagccgtgtc   Aggcctgccc   Aggtgcagag   Cgctcttccg   1380     Cgaccccaac   Agcctctggt   Ccggtctggc   Gcgccctcgc   Tttcccagag   Ggcgacctgg   1440     Gctatggcgg   Ccgtggcgct   Ggcgagcggg   Acacgcctcg   Gccttgtcct   Cgagctgctc   1500     Ccgggacagc   Ccgcgctgcc   Ccgggcgcgc   Cgggtgagtg   Cggggccgga   Gcctggaagc   1560     Agtcttggcc   Ctgccctggg   Ttctaggccc   Ggagacgggg   Tggtgcggcg   Gctgggaaat   1620     Gggggtacaa   Cccagagtga   Ggggcctcga   Gggacaggca   Gcacagcgga   Gtcgacaccc   1680     Ctggacctga   Gcctcaagga   Gagcagacgt   Gcagcggcac   Ggggttgagc   Cgactgctgg   1740     Ggcagagcgc   Acagagtgct   Gtcgggggcg   Atgaatggcc   Gaaatttcag   Agctgccttt   1800     Acagagctgg   Tttagtttga   Gctgggtatt   Aggttgaaaa   Ggaatttgca   Atgcaggagc   1860     Aggaaggaag   Aactggatat   Tcaggcaaga   Gtagccgcag   Gtgcaaggac   Acagaacagg   1920     Gtgaggaaag   Agtttggttt   Cccaatgcaa   Tggtgagagg   Atcggagatg   Agaggtgtgg   1980     Tggctgatga   Tcctggccag   2000       <210>   80   <211>   2000   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   ZNF669     <400>   80   Gcctgtaatc   Tcagcgcttt   Aggaggccga   Gacgggcgga   Tcacttaagg   Tcaggagttc   60     Gagaccaacc   Tagccaacat   Ggcgaaaccc   Tgtctctacc   Aaaaatacaa   Aaattagctg   120     Ggcgtggtgg   Cgggcgcctg   Taatcccaac   Tactcgggag   Gctgaggcag   Gagaatcgct   180     Tgaacccggg   Agtcagaggt   Tgcaatgagt   Gagactgcat   Cattgcactc   Cagcctggcg   240     Acagggcgag   Attccgtctc   Caaaaaaaaa   Aaaaaaaaaa   Aaaaaaaaga   Atatggtttg   300     Cttcctcatt   Aaccttatca   Aagcctctca   Tttacgcccc   Ttctgtggac   Cccaaaccac   360     Aaaccatgac   Tgcggtacct   Ggtttatgaa   Tcgccgtttg   Ctcaaacaca   Cggtttaacg   420     Ttttaacaaa   Gcctcggctt   Aattttaggg   Gaagaaaggt   Gggactggaa   Gccccatgaa   480     Ccacagctcc   Tcccatgctg   Gaaccccgca   Caccgagaca   Ccgagtcggg   Gctctcccgc   540     Atcaccctcc   Cgtggtcacc   Acactacctg   Gataggggag   Gcgaggggtt   Cccgacaggg   600     Ctccggccgg   Cggaagtggc   Gcccgcaggt   Acagacagga   Tgcaggggtt   Ccgctgcccg   660     Ccccgcccgg   Cccggccctg   Aacagaagag   Gactgagccc   Cggctacgcc   Acggcgactc   720     Ggtccgcagg   Ttccggagcc   Gatggcgtgg   Aggcccgagt   Cgcgccacag   Caggtttcaa   780     Ccagccctct   Tctccacttc   Gggaagccag   Gcgcagtcca   Ctcaccattc   Ctcggcttcc   840     Cgggtgtcct   Ggcgtcagct   Agggatgtcc   Caatactcgc   Aggtcacagg   Gtggcagagg   900     Ctgctgcaga   Gccacctggg   Cctcccagag   Ccaagaacta   Gcagcggaga   Ctaacaggaa   960     Gaggcggctc   Cggcgaagga   Gagacaaagc   Aaccgccagg   Cagatcccgg   Aagccgccct   1020     Ctcctttccg   Gcggcgcgcc   Tgattgaacg   Gtccccaccc   Cagcgcccct   Gattggatgg   1080     Ggcttcaggc   Cccgcccctc   Aggccctgag   Tgacaggaga   Ttgcgatctc   Acgtgaggct   1140     Ggatgaggtc   Agaatgaccg   Cttttggcct   Agcggtttgt   Aggcggtgcg   Tccttcctgc   1200     Gctgggatcc   Gaccatgcaa   Gaaggacatt   Cacatttaac   Ctgtatacaa   Gttatagcta   1260     Tttgtgcctt   Tttatatat   Atatatatat   Aaaattggaa   Gcaatataat   Gacagttctg   1320     Taactgccca   Gggagttcac   Cttgcccgct   Acctagacag   Agccgatttc   Tcaagacagg   1380     Ggaatagcaa   Tagagaaaga   Gtaattcacg   Cagtgtcctc   Tgtgcgggag   Accggagttt   1440     Ttttatttta   Ttttattttt   Ttgaaacaga   Atcttgctct   Gtctcccagg   Ctggagtgca   1500     Ggcttggagt   Tttatgatta   Ttcaaatcag   Tctccctgag   Catttggggt   Aagagtattt   1560     Gaagagttta   Ttttgccaag   Gttggggatg   Catatgcatg   Acacagcctc   Agtagktct   1620     Tgatgacatg   Tgcccaaggt   Ggtcagagca   Cagcttggtt   Ttgttggaga   Gaaatgctcg   1680     Gtgccgcaaa   Gtgaaaccag   Cactcaagcg   Aaagttttct   Cagcaacgca   Atttacttct   1740     Gcagaagcgt   Gctgctcgca   Tcaatcacga   Tcgcaagagc   Acactgaaca   Gaggaaagca   1800     Ggggttttta   Ttcctaacgc   Agtccctacc   Tctggcatgg   Gctggggtca   Gaccgcacga   1860     Tctaaactga   Cccggttggc   Tatttgtgaa   Tattttccca   Aataaggaag   Ggggaagggg   1920     Gatgtgagtt   Acaatggtgg   Gacttgcggt   Ttccaaggga   Gaaatgggtg   Cagagcaggt   1980     Aaccaaggga   Acagatgtga   2000       <210>   81   <211>   2002   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   COL6A3     <400>   81   Ccctgcagcc   Ccaggggccc   Tgccttagac   Actcagcatg   Ctgcccaaat   Gcccaattcc   60     Ttcttctcct   Ctgacccctg   Caactccttt   Aagcaacccc   Aagggacaaa   Gtctccaata   120     Gagacttcag   Gttcctggaa   Agacgaaagc   Ttgacggcaa   Tgactgagcg   Accctttact   180     Tggccctgat   Cctgagcacc   Agaggtactc   Caatcttgtg   Aaagcagcaa   Atgtgctcca   240     Ccaggacctt   Cccatgggcg   Gccctgggca   Gaaaacccat   Gcaggttgtt   Gcaccctgac   300     Ctagtgtcac   Cacccagaga   Gctcagagaa   Catctcccag   Cggagccgcc   Cggcagggag   360     Ctatgctagt   Cctcagcaaa   Gacgcttctg   Caaacaaagc   Ggatcccgaa   Tgggttttag   420     Aaggcggcag   Taacttaaat   Aaatcatggg   Ccgaaacaca   Ctgccgcccg   Gaatgcacag   480     Ggcgcgtgta   Gcagccacag   Acacgcggtg   Gaaaagtgct   Cacactctta   Ggcaatcatg   540     Accttaacca   Atttaaggaa   Atcccattgc   Cataaagtga   Gaaagaaaaa   Tcagcggaat   600     Cttccagaga   Cctaaaacat   Gtacagaaaa   Ctggcgatca   Gcatgaacgt   Aagagccact   660     Aacgctacct   Gaagaaggadc   Acttcaggtt   Aagagcattt   Cctttagcc   Ccaaacctgg   720     Aaaaacagaa   Gagaaatcac   Acttacccct   Gagcaaacct   Gaaggcgtgt   Gtccctgggc   780     Tcctcgattc   Aattaggttt   Gaataggatg   Catacttttc   Ccactcactg   Cgtctctttt   840     Tctttttgca   Gcctttctcc   Accaaaaaag   Tggagactca   Gagctgcgga   Ggaaaactct   900     Tgcagtcctt   Gcaggaggct   Ggagcccagg   Agaactgaac   Ggcctttggt   Ggaagactga   960     Gctccaaact   Ggactggggc   Cagggatacc   Agtcagggct   Tcctccagct   Cctcctcctc   1020     Ctcctcctcc   Ctcccggacc   Cctcctctcc   Ccctcctcac   Tgcagaactg   Acccaaaact   1080     Gtaaatgaaa   Ccagactcct   Ccactctgtt   Tcttctggcc   Cccgctcagg   Ctgatgtcac   1140     Cctctgaatt   Ctgtcttcac   Cctacaagcg   Tttagctgga   Ctcctgcaag   Ccccaactct   1200     Taaaaaaaaa   Aattgaccac   Tcctactcgt   Caccttttgg   Gctgggccct   Tggcgtcaaa   1260     Aagaataaat   Tttggaattt   Cttcgtgggt   Atccatggtt   Ttcctgcaat   Gttttccaac   1320     Accatctgaa   Aggaaaacag   Gaaatgcagt   Cccccgctta   Ccctcaccac   Accctcccat   1380     Ttcttcttga   Agtttctgaa   Ttgagacttc   Tactaataac   Ttcccccttc   Aaatagaaaa   1440     Accagcaatt   Aaaatcgcct   Tggttttctg   Ttaaccaaag   Ctctgttcac   Cggcaaaaaa   1500     Aaggaggcta   Catttctctt   Aatttctata   Tctaatgatt   Ctgattgtgg   Cgcttatagg   1560     Cccattctag   Gcacagacgg   Ggtaataaaa   Atggttatct   Tgccaaagct   Tcgggaaaat   1620     Acttgagtaa   Gaacttctgt   Ttctagaaag   Ctttgcacat   Ttcaaaacac   Ttcaatatac   1680     Attctctcct   Ttatcacaaa   Catcaacacc   Ctaagccctt   Ttaaatagaa   Agatgtcttc   1740     Ttttattagg   Tgaaattgtg   Gtcccatttt   Acagatgaaa   Gaaacaggct   Gggcacggtg   1800     Gcttatgcct   Gtaatctcag   Cacttcggga   Ggctaaggca   Ggcagatcac   Aaggtcagga   1860     Gttggagacc   Agcctggcca   Acatggtgaa   Acccctacta   Aatctctact   Aaaaatataa   1920     Aaattagcca   Ggcatggtgg   Caggcgcttg   Tagtcccagc   Tatttgggag   Gctgaggcag   1980     Gacaattgct   Tgaacccagg   Ag   2002       <210>   82   <211>   2002   <212>   DNA   <213>   Homo   Sapiens     <220>   <223>   CPEB1     <400>   82   Acccactcgc   Caggctgagg   Gtccgaacag   Cacagcccag   Agtgggctcg   Ggtcgctccc   60     Cgcctacgcc   Acctccgcgg   Cctgcaagcc   Taaccctctc   Ccgcccatga   Ccaggaccca   120     Cctcaatgcc   Gccagcccgg   Cgggtctccc   Gggcacgaag   Ccccgccagt   Cttccgccct   180     Cgcgccacac   Tacctggcca   Gccccgcccc   Cgagactccc   Tctccggcgc   Caagcgaagg   240     Tgtgaagcca   Cgtgacctgc   Ccaggattgg   Gaagccgcac   Gaggggcttg   Agccctccac   300     Cttaaaggtg   Ccgcgaccgc   Cgccgtcgtg   Gggctctcca   Cagagcacgg   Ggtctacgcc   360     Gtcagcagcc   Ccgccccgtc   Ccgcccgggc   Gcccccaccg   Cgcgccgggt   Gctaaagaga   420     Cccgcagggg   Gcgtgagctt   Ccaggcccag   Cggcttcggg   Tctcccgtgc   Gacggcagtg   480     Tgagaaagaa   Acgttccggg   Cgccggtgct   Cctttatgtc   Cggtcagctc   Ccgtctggac   540     Agacgctcga   Ggccgcctgg   Aggccgcagt   Gcggctcgga   Ggccccaccg   Gccgcccccg   600     Cagggctgcg   Gcgcctttaa   Gcccaaaggc   Cctgagtcac   Gaggaggctc   Cctgcccccc   660     Tcgccctcca   Cccctccacg   Aggccccacg   Cccgcgggca   Cgtgaccgcg   Ccccgcccgg   720     Gactcgcccg   Cacggggcgg   Gggatggggg   Taccgcggcg   Cgggacccgg   Ctgcgcgcgg   780     Accgttagct   Actgcggccg   Ggacgcggcc   Ccgcccaggc   Gaggggggggg   Tggctcttac   840     Cagcgggaac   Gccatggggc   Cggtgtggcc   Ctgcggggct   Gacgggctga   Ccggccagcc   900     Ggcgggcgag   Agacgcgcac   Gcacgtgggc   Actatttttg   Cagcgggccg   Cgcgcagccc   960     Cgcaccccgg   Cagcttatga   Agctcctacg   Agccgctcct   Cggagccgcc   Ccccggccgg   1020     Atgcggagca   Cctgtgtcgg   Ccccgcccgg   Gccctcgcct   Ccgccccctc   Gcgccccgcc   1080     Cctcctagca   Ggccgagccg   Aggaggdcct   Cgccgcccac   Ccggaacccg   Gcggggactg   1140     Ccgccgctgc   Tagccacagc   Tgccccctgg   Ggggccagag   Acctaagcct   Gagcgcgcca   1200     Tcacctaagt   Gacccttgcc   Gagtcactgt   Ctgccctggg   Cctcagtttc   Cctcttaacg   1260     Aaagagggca   Cgatttacaa   Gcccctgcga   Gcggcggcga   Tcgcttcgtc   Agtagagcct   1320     Cgtgtccgcg   Ctccttctct   Tccagtgatc   Tctccagggc   Gagagcctgc   Cctggcatcc   1380     Ttggtcggaa   Ctgtagcccc   Tgggctccag   Gaggcgcact   Cactttagac   Cctctgctcc   1440     Gtgcgctgca   Gagggggccg   Cgagagtcag   Gaagttccag   Aaagttccaa   Agacatcact   1500     Ggtcctcttt   Ggaccggagt   Tctccggaga   Aaccgcttcc   Ggcgctcctg   Acacactgag   1560     Atagaaagtt   Tcacagaaat   Agggcaaggg   Atagggcgag   Ggctccaggg   Caggcgtcct   1620     Agggcacctg   Gcgcaggggc   Ggaccggaaa   Ccccaggcaa   Acgcagagtc   Ggagatggca   1680     Ttccaggcgg   Aagatcaagc   Aaaggcagag   Agggaggacg   Gcaccgagcg   Gctccctctg   1740     Accaggactg   Agtaggatgc   Gacctgatac   Cgccggaggg   Aagcctgggc   Ccggtttgta   1800     Agggggcttt   Attctgcaga   Cagcaggaaa   Actattagag   Aattgtaaaa   Ggggttggca   1860     Gttgtcgggt   Ctgttttaag   Gtgttgctgg   Agacatagaa   Gaggttggac   Agaaaagggg   1920     Gaaaacaagg   Gactggagtg   Gggaggaaag   Ggaccagagt   Tttatgaaca   Ttgctaagtg   1980     Ttttacatgt   Gtcatgttat   Ca   2002

Claims (19)

A method for assessing whether a body has malignant endometrial cancer comprises at least the following steps: (a) obtaining the same copy from the individual; (b) determining the methylation status of at least one target gene in the sample, wherein At least one target gene is selected from the group consisting of CELF4, EFS, ZNF334 and ZNF662; (c) determining whether the at least one target gene is highly methylated; and (d) evaluating the individual based on the result of step (c) Whether or not suffering from malignant endometrial cancer, wherein the hypermethylation of the at least one target gene represents the individual suffering from malignant endometrial cancer. The method of claim 1, wherein in step (b), the methylation status of two, three or all of CELF4, EFS, ZNF334 and ZNF662 is determined. The method of claim 1, wherein the sample is a tissue, cell, tumor or biological fluid from the individual. The method of claim 3, wherein the sample is from serum or plasma. The method of claim 3, wherein the sample is from a cervical scraping cell. A method for assessing whether a body has an ovarian tumor comprises at least the following steps: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein the at least one target The gene is selected from the group consisting of AOX1, CACNA2D4, COL6A3, CPEB1, FAM115A, NRN1, TBX15, PCDHGA11, PHOX2A, UCKL1, and WDR86; (c) determining whether the at least one target gene is highly methylated; and (d) And assessing whether the individual has an ovarian tumor based on the result of step (c), wherein the hypermethylation of the at least one target gene represents the individual suffering from an ovarian tumor. The method of claim 6, wherein the at least one target gene is NRN1, TBX15 or both. The method of claim 6, wherein the at least one target gene is selected from the group consisting of NRN1, AOX1, TBX15, and COL6A3. The method of claim 6, wherein the sample is a tissue, cell, tumor or biological fluid from the individual. The method of claim 6, wherein the sample is from serum or plasma. The method of claim 6, wherein the sample is from a cervical scraping cell. A method for assessing whether a body has an ovarian tumor and its degree of malignancy comprises at least the following steps: (a) obtaining the same copy from the individual; (b) determining the methylation status of at least one target gene in the sample, wherein The at least one target gene is selected from the group consisting of: NRN1, AOX1, TBX15, COL6A3, and WDR86; and (c) determining whether the at least one target gene is highly methylated; (d) based on step (c) As a result, it is evaluated whether the individual has an ovarian tumor and a degree of malignancy thereof, wherein hypermethylation of the at least one target gene represents the individual suffering from an ovarian tumor, and hypermethylation of AOX1, WDR86 or both represents that the ovarian tumor is malignant. The method of claim 12, wherein the sample is a tissue, cell, tumor or biological fluid from the individual. . The method of claim 12, wherein the sample is from serum or plasma. The method of claim 12, wherein the sample is from a cervical scraping cell. A method for assessing whether a body has a colon tumor comprises at least the following steps: (a) obtaining the same copy from the individual; (b) determining a methylation status of at least one target gene in the sample, wherein the at least one target The gene is selected from the group consisting of PAX6, TBX15 and ZNF334; and (c) determining whether the at least one target gene is highly methylated; (d) assessing whether the individual has a colon tumor based on the result of step (c), Wherein the hypermethylation of the at least one target gene represents the individual suffering from a colon tumor. The method of claim 16, wherein the sample is a tissue, cell, tumor or biological fluid from the individual. . The method of claim 16, wherein the sample is from serum or plasma. The method of claim 12, wherein the sample is from colon tissue.