TW201718031A - Gel composition for ultrasound procedure and related methods - Google Patents

Abstract

A gel composition for an ultrasound procedure comprises: (a) a vehicle; (b) a chelating agent; (c) an anti-inflammatory agent; (d) a thickening agent; (e) a skin-conditioning agent; (f) a humectant; (g) a preservative; and (h) a neutralizer. A method of preparing the gel composition and a method of applying the gel composition for an ultrasound procedure are also disclosed.

Description

Gel composition for ultrasonic procedures and related methods

The invention in general relates to a gel composition, and more particularly to a gel composition for an ultrasonic procedure and related methods.

The compositions are well known to those skilled in the art and have been used in many industries and end uses. A specific example of such end use applications is an ultrasonic program (such as ultrasonic scanning). During ultrasound imaging, a probe or transducer that emits acoustic waves is placed near the body of the subject, and the acoustic wave is utilized for a variety of purposes. For example, ultrasound imaging can be utilized to identify or map the internal view of the patient's body, such as muscles, tendons, organs, fetuses, and the like. Furthermore, ultrasound procedures are increasingly being utilized to treat skin disorders that are not related to ultrasound imaging. For example, ultrasound procedures can be used to reduce wrinkles, or to improve skin conditions, such as the subject's face and/or neck. Gel compositions are typically used as an interface between the probe or transducer and the skin.

Conventional gel compositions have a number of disadvantages. For example, some conventional gel compositions cause acoustic reflection due to poor acoustic properties, negatively affecting the finished image. Other conventional gel compositions that do not provide suitable lubricity, Or prematurely dry when exposed to ambient air, or have an unpleasant appearance or feel. Moreover, some conventional gel compositions, while providing the lubricity desired by us, have low viscosity and are therefore difficult to maintain in a localized area of the body, especially in the vertical position of the main system for ultrasonic processing. Time.

The present invention provides a gel composition for an ultrasonic procedure. The gel composition comprises: (a) a carrier in an amount of 70 to 95% by weight (wt%); (b) a chelating agent in an amount of more than 0 to 0.1% by weight; (c) an anti-inflammatory agent, content Is greater than 0 to 0.3 wt%; (d) a thickening agent, the content is greater than 0 to 1.0 wt%; (e) a skin conditioning agent, the content is greater than 0 to 25 wt%; (f) a humectant, the content is More than 0 to 25 wt%; (g) a preservative in an amount of more than 0 to 4 wt%; and (h) a neutralizer in an amount of more than 0 to 1 wt%, each of which is based on the total gel composition Redo as a basis for calculations.

The present invention also provides a method (preparation method) for preparing the gel composition. The preparation method comprises: combining at least the (a) carrier, (b) a chelating agent, (c) an anti-inflammatory agent, (d) a thickening agent, (e) a skin conditioning agent, (f) a moisturizing agent, (g) preservative And (h) a neutralizing agent to prepare the gel composition.

Further, the present invention provides a method (application method) for applying the gel composition to an ultrasonic program. The method of application comprises applying the gel composition to the skin of the subject.

A gel composition for an ultrasonic procedure is disclosed, along with methods for its preparation, and methods of use thereof on the subject's skin. The gel composition has excellent physical properties, including acoustic properties, and is therefore well suited for use in ultrasonic procedures. For example, the gel composition can be applied over the skin of the subject, at the interface between the skin and the probe or transducer. However, the gel composition is also suitable for other end uses that are separate from the ultrasonic procedure and is not limited to this end use or application.

The gel composition comprises (a) a carrier which is generally the main component of the gel composition. The (a) carrier is a carrier for the composition of the gel composition, and may be any carrier which can be used for carrying, or partially solubilized, or solubilized, or with the composition of the gel composition. Mix it. In a particular embodiment, the carrier comprises water. In addition to water, the gel composition may also comprise a carrier other than water, that is, a combination of different carriers. In other embodiments, the (a) carrier is water.

When the (a) carrier comprises water, the moisture of the gel composition (a) carrier can be obtained from any source and optionally purified. For example, the moisture can be from natural sources, tap water sources, and the like. Examples of the purification method include filtration, distillation, deionization, demineralization, reverse osmosis, and the like. Typically, the moisture of the gel composition is purified to remove perceptible contaminants therefrom.

The content of the (a) carrier in the gel composition is composed of the gel The total weight is calculated based on about 70 to 95, or 72 to 93, or 74 to 91, or 76 to 89, or 78 to 87, or 80 to 85 weight percent (wt%). The amount of (a) carrier in the gel composition can be varied based on the choice or relative amount of other ingredients (including optional ingredients) within the gel composition.

The gel composition further comprises (b) a chelating agent. Combinations of different chelating agents can also be used in combination as (b) chelating agents. The (b) chelating agent of the gel composition is not limited.

The (b) chelating agent generally isolates metal ions that may be present in the gel composition, such as (a) the nominal amount of the carrier, or the introduction of the other component, or the presence of the gel. The person in the surrounding environment when the object is molded. Specific examples of suitable chelating agents include alkali metal and/or alkaline earth metal salts such as salts of ethylenediaminetetraacetic acid and/or ethylene diamin tetraacetic acid and/or nitrilotria acetate. Specific species include sodium EDTA; disodium EDTA; tetrasodium EDTA; dilithium EDTA; EDTA®; disodium manganese EDTA; calcium disodium EDTA; sodium nitrilotriacetate; disodium nitrilotriacetate and the like. Combinations of different chelating agents can also be used together. In one embodiment, the (b) chelating agent comprises disodium EDTA.

The content of the (b) chelating agent in the gel composition is greater than 0 to 0.1, or 0.1 to 0.9, or 0.2 to 0.8, or 0.3 to 0.7, based on the total weight of the gel composition, or 0.4~0.6wt%. The amount of (b) chelating agent in the gel composition can be varied based on the choice or relative amount of other ingredients (including optional ingredients) within the gel composition.

Further, the gel composition includes (c) an anti-inflammatory agent. Combinations of different anti-inflammatory agents can also be used together as the (c) anti-inflammatory agent. Examples of anti-inflammatory agents suitable for use in the gel composition include: aloe vera, methylsulfonylmethane (MSM), emu oil, chondroitin, glucosamine , capsaicinoid, arnica extract, grape seed extract, coriander oil, marigold extract, nettle leaf extract Extract), Roman chamomile oil, blue-bottle extract, St. John's wort, willow bark extract, witch hazel extract Witch hazel extract), feverfew extract, barley grass, black cohosh, black snakeroot, bugbane, squawroot , Boswellia, borage, bromelain, burdock, calendula, cayenne, dandelion, devil's claw root, dehydrogenation table Androsterone (DHEA, dehydroepiandroste Rone), Echinacea, elderflower, evening primrose oil, flaxseed, ginko, ginger, gingseng, Hawthorne ), kaempferol, licorice (such as licorice extract), life root, golden Senecio, squaw weed, golden groundsel , cocash weed, coughweed, ragwort, golden ragwort, grundy swallow, linden, marj oram , meadow sweet, n-dihydroguaiac acid (NDGA), neem, nep 28, Padma 28, quercetin, shea butter, turmeric, Wild yam, wormwood, yucca, bisabolol, sucralfate, lipo-glycine (LIPACIDE), guaiazulene, Essential fatty acids, plant seed oils and other vegetable-derived polyunsaturated fatty acid derivatives, or any other anti-inflammatory agent. Essential fatty acids (EFAs) may comprise omega-3 and omega-6 fatty acids, such as linolenic acid alpha linolenic acid. Further, any weeds or various agents known to contain EFAs may be contained in the gel composition as the (c) anti-inflammatory agent. Examples of such weeds include flaxseed and evening primrose oil.

In a particular embodiment, the (c) anti-inflammatory agent of the gel composition comprises a licorice extract. As used herein, "licorice extract" refers to any compound, or mixture of compounds, of the genus Glycyrrhiza glabra, comprising licorice, glycerrhetic acid (also known as enoxolon, ural licorice). (uralenic acid), glycyrrhizic acid (also known as glycyrrhizin acid, glycyrrhetinic acid, and glycerrhtic acid glycoside), derivatives thereof, and combinations thereof. Specific examples of the licorice extract derivatives include salts (such as metal salts, ammonium salts, and the like) and esters (such as saturated fatty acid esters, unsaturated fatty acid esters, diacid half esters, acid esters, and Similar classes, etc.).

In certain embodiments, the (c) anti-inflammatory agent comprises a licorice extract ester derivative, such as a saturated and/or unsaturated glycyrrhetic acid and an ester of glycyrrhizic acid. A representative licorice extract ester derivative for use in a gel composition, comprising monoammonium glycyrrhizinate, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, 1- 1-beta-glycyrrhetic acid, stearyl glycyrrhetinate, 3-stearyloxy-glycrrhetinic acid, 3-dodecyloxy Disodium 3-succinyloxy-beta-glycryyhetinate and combinations thereof. In one embodiment, the (c) anti-inflammatory agent comprises dipotassium glycyrrhizinate.

The (c) anti-inflammatory agent is contained in the gel composition in an amount of more than 0 to 0.3% by weight, or 0.01 to 0.3% by weight based on the total weight of the gel composition. Similar to the other ingredients, the amount of (c) anti-inflammatory agent in the gel composition can be varied based on a variety of factors, including its choice, and the presence or absence of a variety of optional ingredients.

The gel composition further comprises (d) a thickening agent. Combinations of different thickeners can be used together as (d) thickener. The (d) thickening agent causes the gel composition to produce a viscosity, or other modified rheological property, which is desired, such that the gel composition is a colloid. In certain embodiments, the (d) thickening agent is also referred to as a thixotroping agent.

The (d) thickener is not limited and is generally used to increase viscosity or to alter the rheological properties of the gel composition. The (d) thickening agent can be a polymer and/or a water absorbent material. An example of a thickening agent suitable for use in a gel composition is an acrylic acid polymer. For example, the (d) thickener may comprise a polymer of acrylic acid which may be crosslinked, for example, allyl ether. Examples of thickening agent available on the specific business include trade name Carbomer ^TM persons, which is available from the city of Covington, Kentucky Ashland company. In one embodiment, the (D) a thickening agent comprising Carbomer ^TM 980, commercially available from Ashland City, Covington, Kentucky company.

Examples of additional thickeners include acrylamide copolymers, ácrylate copolymers and salts thereof (such as sodium polyacrylate), xanthan gum and its derivatives, and fibers. Gum (cellulose gum) and cellulose derivatives (such as methyl cellulose, methyl hydroxypropyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, polypropyl hydroxyethyl cellulose), starch and starch derived (such as hydroxymethyl amylose and amylase), polyethylene oxide, carbomer, sodium alginate (alginates, such as sodium alginate), gum arabic, cassia gum, locust bean gum, hard Dextran gum, gellan gum, murine gum, karaya gum, carrageenan, guar gum and guar gum derivatives, cocoamine amines (including cocoamidopropyl betaine) Cocamidopropy betaine", cocoamide MIPA"), and mixtures thereof.

In many embodiments, the (d) thickener of the gel composition The content is greater than 0 to 1, or 0.05 to 1, or 0.2 to 0.9, or 0.4 to 0.8, or 0.6 to 0.7 wt%, based on the total weight of the gel composition. Like other ingredients, the relative amount of the (d) thickener in the gel composition can vary based on a variety of factors. When the gel composition further comprises (h) a neutralizing agent to neutralize the (d) thickening agent (as described below), the amount is such that the gel composition is before or before the reaction. Based on calculations.

The gel composition further comprises (e) a skin conditioning agent. Combinations of different skin conditioning agents are also used in combination as the (e) skin conditioning agent. The (e) skin conditioning agent provides a number of functions in the gel composition, including providing a soothing property when the gel composition is applied to the subject's skin. Further, depending on the selection of the (e) skin conditioning agent, the (e) skin conditioning agent may also have properties similar to humectants and softeners.

The (e) skin conditioning agent can also produce or retain moisture on the skin. Increased skin moisture can make the skin softer and supple. Skin conditioning agents can be used to mimic the activity of normal skin secretions in maintaining suppleness in the skin and to provide a barrier to evaporation. Conventional skin conditioning agents generally comprise two broad types of use: occlusives and humectants. The occlusive wetting agent forms a layer on the skin which reduces the rate of evaporation. Humectants are non-occlusive, hygroscopic substances that retain moisture and allow moisture to be applied to the skin. Humectants can also function by improving skin lubricity.

The (e) skin conditioning agent may comprise a single moisturizing ingredient, or may It includes a number of ingredients that are included for a variety of purposes, such as softeners, emulsifiers, ester-like compounds, surfactants, thickeners, and preservatives. Further, the (e) skin conditioning agent can have both occlusive properties and softening properties. Moisture can occur along with the ingredients that are retained in the skin conditioning agent. The concentration of the skin conditioning agent incorporated into the gel composition and the choice of its type have no negative effect on its stability and properties at the time of use.

Suitable skin conditioning agents include long chain C12-C22 aliphatic acids, liquid water soluble polyols glycerin, propylene glycol, sorbital, polyethylene glycol. Ethoxylated/propoxylated ethers of methylglucose, ethers of ethoxylated/propoxylated lanolin alcohols (ethoxylated/propoxylated ethers) Of lanolin alcohol), coconut fatty acid, tallow fatty acid, non-occlusive liquid water-soluble polyol, concentrated aloe vera gel, freeze-dried powder of aloe vera, aloe vera oil extract, amine Natural plant extract (avocadin), calcium protein complex, cashew oil, chia oil, chitin, acid, amniotic fluid, pear crocodile solvent Chitin, chitosan, chitosan PCA, cholesteric esters, chondroitin sulfate, collagen, collagen amino acids (collagen) Amino acids) Copper-protein complex (copper protein complex), dioctyl maleate (dioctyl maleate), pentaerythritol fatty acid Dipentaerythritol fatty acid ester, elastin, ethyl panthenol, evening primrose oil, glycereth-12, glycosphingo lipids, hyaluronic acid, Hybrid safflower oil, hydrogenated polyisobutene, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed fibronectin, hydrolyzed mucopolysaccharides, hydrolysis Hydrolyzed silk, hydrolyzed wheat protein, jojoba esters, keratin amino acids, kiwi fruit extract, chytrid MEA Lactamide MEA), lecithins, live yeast cell derivative liposome, marine polyaminosaccharide, mineral oil, mink oil ethyl ether , mucopolysaccharides, mucopolysaccharides, palmetto extract, Leontopodiumalpinum extract (Edelweiss), pantethine, paraffin, polyethylene glycol-4 (PEG-4), PEG-6, PEG-8, PEG- 12. PEG-100 stearate, perfluoropolymethyl-isopropyl ether, petrolatum, petroleum wax, pistachio oil , placenta extract, plankton extract, polyamine Polyamino sugar condensate, polybutene, polyglyceryl methacrylate, polypentaerythrity ltetralaurate, polypropylene glycol-10 butanediol ), PPG-20 methyl glucose ether distearate, royal jelly extract, saccharide isomerate, selenium protein Complex), serum albumin, sodium hyaluronate dimethylsilanol, sodium lactate methylsilonol, sodium mannuronatemethylsilanol, Water soluble collagen, super oxide dismutase, super oxide dismutase liposome, tissue extract, linoleate vitamin E (tocopheryl) Linoleate), lipophylic moisturizers, such as lysolecithin, lecithin, gallbladder Sterols, sitosterol, cholesterol esters, sphingolipids, or ceramides, low molecular weight wetting agents such as serine, glutamine ), sorbitol, mannitol, glycerol, sodium pyrrolidone-carboxylate, butanediol, propylene glycol, lactic acid, or lactate, high molecular weight wetting agents, such as hyaluronic acid, sodium hyaluronate ), elastin, alginic acid, mucopolysaccharide, polyaster Polyaspartic acid salts, or water-soluble chitin, hydrocarbon oils, hydrocarbon waxes, silicones (dimethicone), double PEG- Bis-PEG-18 methyl ether dimethyl silane wax, fatty acid derivatives, cholesterol, cholesterol derivatives, di-and tri-glycerides, vegetable oils, vegetable oils Combinations of liquid nondigestible oils, combinations of liquid digestible or nondigestible oils with solid polyol polyesters, acetyl glycerol Acetylglyceride esters, alkyl esters, alkenyl esters, lanolin and its derivatives, milk tri-glycerides, wax esters, Glycerides and derivatives thereof (eg, PEG-7 glycerol cocoate), beeswax derivatives, sterols, phospholipids, or any other skin conditioning agent.

Examples of other suitable skin conditioning agents, such as occlusive skin conditioning agents, include petrolatum, paraffin, waxes, oils, mineral oils, beeswax, lanolin and oil-soluble lanolin derivatives, saturated and unsaturated fatty alcohols, For example, behenyl alcohol, squalene, various animal and vegetable oils, such as almond oil, apricot oil, apricot pit oil, avocado oil ( Avocado oil), cade oil, castor oil, cinnamon oil, corn oil, cottonseed oil, evening primrose oil, grape oil, grape Grape seed oil, hazelnut oil, jojoba oil, linseed oil, liver oil, macadamia nut oil, mink oil, Neetsfoot oil, olive oil, palm kernel oil, palm nut oil, palm oil, peach pit oil, peanut oil (peanut oil), pine oil, pistachio nut oil, poppyseed oil, rapeseed oil, rice bran oil, rice germ oil Oil), safflower oil, sasanqua oil, sesame oil, sesame seed oil, soybean oil, sunflower oil, sunflower oil Sunflower seed oil), tsubaki oil, walnut oil, wheat germ oil, wheat germ oil, teaseed oil, triglyceride Triglycerine), glycerinetrioctanate, glycerinetriisopalmitate, cocoa butter (cacao f At), beef tallow, sheep fat, hog fat, horse fat, hydrogenated oil, hydrogenated castor oil, Japanese wax Japanese wax), shea butter, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, tree wax Wax), spermaceti, montan wax, bran wax, lanolin, reduced lanolin, hard lanolin, kapok wax Wax), sugarcane wax, jojoba wax, shellac wax, or any other skin conditioning agent that exhibits occlusive properties.

The (e) skin conditioning agent may comprise an agent that mimics the natural ingredients and functions of the plant, including vitamins, hydroxy acids, and retinoids. The vitamin may comprise vitamin A, retinol, retinol palmitate, inositol, pyridoxine chlorate, benzyl nicotinate, Nicotinamide, dlα-tocopheryl nicotine, magnesium ascorbyl phosphate, tetrahexyldecyl ascorbate, ergocalciferol, dlα-tocopherol (dlα-tocopherol), dl-α-tocopherol-2-L-ascorbic acid-potassium dipotassium (potassium dl-α-tocopherol-2-L-ascorbic diester), dl-α-tocoenyl-acetate (dl-α-tocopheryl acetate), pantothenic acid, biotin, or any other vitamin. Some severely dry skin may be reduced based ingredients (α - hydroxy acids (alpha hydroxy acids "AHA") β- and hydroxy acids (beta hydroxy acids "BHA") , and salts thereof comprising the retinoid-based hydroxy acids. It is classified according to the number of carboxyl groups in its structure. Monocarboxylic acids are glycolic acid, lactic acid and mandelic acid. Dicarboxylic acids include maleic acid and tartaric acid. The citric acid found in citrus fruits is implemented. BHAs cover most salicylic acids and their derivatives. AHAs have been shown to exfoliate. Therefore, they are in hyperkeratotic conditions (hyperkeratotic) Useful under conditions. The other ingredients of skin conditioning agents may include elastin, lecithin, sodium hyaluronate, sodium passive cutaneous anaphylaxis, ceramides, natural skin lipids and sterols. , synthetic or natural oils, humectants, softeners, emulsifiers, preservatives, lubricants, greases, natural wetting factors (natural mois Turing factors "NMF"), containing low molecular weight materials such as ammonia, amino acids, glucosamine, creatinine, citrate and ionic solutions ), such as sodium, potassium, chloride, phosphate, calcium and magnesium, sodium pyrrolidone carboxylic acid, adipic acid, lactic acid, oleic acid, stearic acid, isostearic acid, myristic acid And hexadecyl, tetradecyl, isodecyl or isodecyl, or isopropyl esters of adipic, lactic, oleic, stearic, isostearic, myristic and linoleic acids Its corresponding alcohol ester, sodium isostearoyl-2-lactylate and sodium capryllactylate, glycerin, polyethylene glycol, polypropylene glycol (propylene glycol) ), sorbitol, methyl glycol and polyethylene glycol and propylene glycol ethers of methyl glucose, lanolin alcohol, lactic acid, L-valine and other free fatty acids And polyethylene glycol and propylene glycol ethers of lanolin alcohol, lactic acid, L-proline, and other free fatty acids, cocoic acid, tallow acid, naturally occurring non-occlusive liquid water soluble on the skin. Polyols and essential amino acid compounds, as well as stearic acid and lauric acid.

The content of the (e) skin conditioning agent is greater than 0 to 25 wt%, or 5 to 20 wt%, based on the total weight of the gel composition. Like other ingredients, the relative amount of the (e) skin conditioning agent in the gel composition can vary based on a variety of factors.

In a particular embodiment, the (e) skin conditioning agent comprises a combination of skin conditioning agents. In this particular embodiment, the (e) skin conditioning agent comprises at least two (alternatively at least three, or at least four) different skin conditioning agents. For example, the (e) skin conditioning agent can include a combination of butylene glycol, cosmetic wax, glyceride, and polysaccharide.

The cosmetic wax can be any suitable cosmetic wax. In certain embodiments, the cosmetic wax is at least partially water soluble or dispersible, or alternatively, completely water soluble or dispersible. Alternatively, the cosmetic wax may be used in combination with other carrier carriers other than water which may be at least partially dissolved or dispersed in the cosmetic wax. The cosmetic wax may be organic and may additionally comprise an inorganic portion, such as a saline portion. A specific example of an exemplary cosmetic wax suitable for use in the gel component is bis-PEG-18 methyl ether dimethyl silane wax.

The glyceride can be, for example, PEG-7 glycerol cocoate (PEG-7) Glyceryl cocoate).

The polysaccharide can be derived from any source, for example, fermentation of carbohydrates such as sorbitol, glucose, and the like. An example of a suitable polysaccharide is biosaccharide gum-1.

In these embodiments, the amount of butanediol in the gel composition is from 1 to 15, or from 1 to 10, or from 2 to 6 wt%, based on the total weight of the gel composition. The content of the cosmetic wax in the gel composition is 1 to 10, or 1 to 7, or 2 to 4% by weight based on the total weight of the gel composition. The content of the glyceride in the gel composition is greater than 0 to 10, greater than 0 to 5, or 0.5 to 2.5 wt%, based on the total weight of the gel composition. The content of the polysaccharide in the gel composition is 1 to 20, or 1 to 15, or 1 to 10% by weight based on the total weight of the gel composition.

The gel composition further includes (f) a humectant. Combinations of different humectants are also commonly used as (f) humectants. The humectant of the gel composition is not limited. The (f) humectant is different from (e) a skin conditioner and can be distinguished therefrom.

Examples of suitable humectants include, but are not limited to: glycerin, hyaluronic acid, sorbitol, urea (urea), α-hydroxy acids (alpha hydroxy acids), sucrose (Sugars), lactic acid, propylene glycol, triacetin (glyceryl Polyacetate such as triacetate, lithium chloride, sorbitol, xylitol, and maltitol, polydextrose of polymeric polyols, Natural extracts of adipic acid, lactic acid, oleic acid, stearic acid, isostearic acid, myristic acid and linoleic acid saponin, hexadecyl ester, tetradecyl ester, isodecyl ester and isopropyl ester ( Quillaia, hexadecyl, myristyl, isodecyl and isopropyl esters of adipic, lactic, oleic, stearic, isostearic, myristic and linoleic acids) and many of its corresponding alcohol esters (eg sodium decyl-2-lactate) "sodium isostearoyl-2-lactylate", "sodium capryllactylate", hydrolyzed protein and other collagen-derived proteins, aloe vera gel, acetaminophen MEA, naturally occurring compounds on the stratum corneum of the skin, such as pyrrolidone Sodium pyrrolidone carboxylic acid, lactic acid, urea, L-valine, guanidine and pyrrolidone, acetamido MEA, acetamido propyl trimonium chloride, Calcium stearoyllactylate, chitosan pyrrolidone carboxylic acid (PCA), diglycerol lactate, ethyl ester of hydrolyzed silk, Fatty quaternary amine chloride complex, glycerrene-7, glycerol-12, glycerol-26, glycerol-4.5 lactate ), glycerin, diglycerin, polyglycerin, hydrolyzed fibronectin, lactamide MEA, lactam-N-(2-hydroxyethyl) (lactamide N-(2-hydroxyetheryl)), mannitol, methylgluceth-10, methyl glucose-20, methylsilanol PCA, panthenol, PCA, poly Ethylene glycol (PEG), PEG-4, PEG-8, polyamine Polyamino sugar condensate, quaternium-22, sea salts, sodium capryllactylate, sodium hyaluronate, isostearyl Sodium isostearoyllactylate, sodium lactate, sodium laurolaclate, sodium PCA, sodium polyglutamate, sodium stearoyllactylate, soluble collagen, sorbitan laurel Sorbitan laurate, sorbitanoleate, sorbitansesquiisostearate, sorbitan stearate, sorbitol, Sphingolipids, TEA-PCA, ethylene glycol, diethylene glycol, triethylene glycol, and other polyethylene glycols, propylene glycol, dipropylene glycol And other propylene glycols, 1,3-butylene glycol, 1,4-butylene glycol and other butanediols, glycerol, diglycerol And other polyglycerols ( Polyglycerols), mannitol, xylitol, maltitol and other sugar alcohols, ethoxylated (EO) and propoxylated (PO) glycerol adducts (EO) Propylene oxide (PO)adducts), sucrose alcohol EO and PO adducts, adducts of EO and PO with monosaccharides (such as galactose and fructose), adducts of EO or PO with polysaccharides (such as maltose and lactose) , sodium pyrrolidonecarboxylate, polyoxyethylene methyl glycoside, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3- 1,3-butylene glycol, hexylene glycol, xylitol, maltitol, D-mannitol, gluten, glucose, fructose, lactose, cartilage Sodium chondroitin sulfate, sodium hyalonate, sodium adenosine phosphate, gallates, pyrrolidone carbonates, glucosamine, cyclodextrin Cyclodextrin, alpha hydroxy acid (alp Ha hydroxy acids), 2-methyl-1,3-propane diol, or a combination thereof.

The (f) humectant content may be greater than 0 to 25, or 1 to 15, and 1 to 10% by weight based on the total weight of the gel composition. Similar to the other ingredients, the relative amount of the (f) humectant in the gel composition can be varied based on several factors.

In a specific embodiment, the (f) humectant of the gel composition comprises a first humectant and a second humectant. Even in these embodiments, the (f) humectant may include a humectant other than the first and second humectants. In these embodiments, the first humectant comprises glycerin, and the second humectant comprises sodium hyaluronate. The first humectant is typically used in an amount greater than the second humectant. For example, the content of the first humectant in the gel composition is 1 to 15% by weight based on the total weight of the gel composition, and the content of the second humectant is greater than 0 to 1, or 0.01 to 1% by weight. . When the second humectant includes transparency In the case of sodium sulphate, the second humectant can be combined with water prior to incorporation into the gel composition, as described below.

The gel composition also includes (g) a preservative. Combinations of different preservatives can also be used together as the (g) preservative. The (g) preservative of the gel composition is not limited.

Examples of suitable preservatives include grape seed extract, methylparaben, propylparaben, diazolindinyl urea, sorbic acid, benzene. Phenoylethanol, ethylparaben, butylparaben, sodium butylparaben, caprylyl glycol, dehydroacetic acid (dehydroacetic acid), chlorphenesin, or any preservative. Combinations of different preservatives are also used.

In a particular embodiment, the (g) preservative of the gel composition is obtained as a preservative premix. The preservative premix comprises a combination of two or more preservatives in a carrier. One such example is a composition comprising chlorophenyl glyceryl ether and methyl paraben in a vehicle (each of which is 7.5 in the preservative premix) based on the total weight of the preservative premix. Wt%), the vehicle comprises a composition of glycerin and butylene glycol (each of which is present in the preservative premix in an amount of 42.5 wt% based on the total weight of the preservative premix).

In a specific example, the (g) preservative is present in the gel composition in an amount of more than 0 to 4, or 1 to 4% by weight based on the total weight of the gel composition. The amount of the (g) preservative in the gel composition is varied based on the relative amount and selection of other ingredients (including optional ingredients) in the gel composition. When the preservative premix is used as the (g) preservative, the weight of the carrier is typically included within the relative amount of the (g) preservative within the gel composition. Also, when the preservative premix is used as the (g) preservative, the preservative premix is formed on site in the gel composition or may be provided or incorporated as a preservative premix. Typically, the gel composition is formed with a pre-preservative premix which is itself a separate component, as opposed to being formed on the spot.

The gel composition further includes (h) a neutralizing agent. The (h) neutralizing agent is generally used to neutralize the (d) thickening agent, especially when the (d) thickening agent is an acid, for example, an acrylic polymer. Alternatively, the neutralizing agent can be a buffer or alternatively utilized to modify the pH of the gel composition.

The (h) neutralizing agent can be any compound suitable for neutralizing acids. An example of a suitable (h) neutralizing agent is a trialcoholamine such as triethanolamine. Other suitable neutralizing agent examples include basic compounds such as alkali metal hydroxides such as potassium hydroxide (KOH), sodium hydroxide (NaOH), and ammonium hydroxide (NH ₄ OH). As described below in relation to the method, the (h) neutralizing agent may be placed or added to other components after the (d) thickening agent, in order to prevent premature formation. Neutralization.

In many embodiments, the amount of the (h) neutralizing agent in the gel composition is a catalyst amount, for example, greater than 0 to 1, or 0.05 to 1 based on the total weight of the gel composition. , or 0.2~0.9, 0.3~0.9wt%. The amount of (h) neutralizing agent in the gel composition can be varied based on the choice or relative amount of other ingredients, including optional ingredients. If (h) the neutralizing agent is reacted with (d) the thickening agent, as described above, these amounts are based on the pre- or pre-neutralization of the gel composition.

Alternatively, the gel composition may comprise one or more additional ingredients, such as additives. Suitable additives are generally known to those skilled in the art, including but not limited to: oils, extracts, skin protectants, disinfectants, bactericides, pharmaceutical and pharmaceutical substances, analgesics, antioxidants, sunscreens, flooding agents Insecticides, exfoliants, fragrances, dyes, fillers, solvents, vehicles, other types of additives known to those skilled in the art, and combinations thereof. Such additives can be used alone or in combination. The gel composition typically has a viscosity that varies with the relative amount of ingredients in the gel composition or its choice.

In certain embodiments, the gel composition has a viscosity of at least 10,000, alternatively at least 20,000, at least 30,000, at least 40,000 centipoise at 25 °C. For example, the gel composition has a viscosity at 25 ° C of 20,000 to 150,000, or 30,000 to 120,000, or 40,000 to 80,000 centipoise. The gel composition typically has a density greater than water, such as a specific gravity greater than one. The The gel composition typically has a pH range of 5-7, or 5.7-6.6. The pH can be modified by incorporating optional ingredients and modified by modifying, for example, (h) the relative amount of neutralizing agent.

Modification of the relative amounts of the components within the gel composition results in the resulting physical properties of the gel composition and, therefore, the gel composition can advantageously be modified or optimized.

The gel composition has excellent physical properties and is well suited for a variety of end uses and applications, especially ultrasonic procedures. The gel composition is non-runny and can be applied to the subject's skin without flowing or dripping when the primary system stands vertically or on a horizontal substrate. As such, the gel composition is particularly suitable for ultrasonic procedures, regardless of whether the body is in a horizontal (lying flat) or vertical position, as described below. The gel composition also has excellent acoustic properties that do not interfere with sound waves during ultrasonic operation. Furthermore, the gel composition has excellent lubricating properties and thus can serve as the interface we desire between the subject skin and the instrument (such as an ultrasonic probe or transducer). However, the gel composition is not so limited and can also be used in end applications other than ultrasonic procedures. For example, the gel composition can be wiped onto and/or onto the skin independently of the ultrasonic procedure.

The present invention also provides a method for preparing a gel composition (preparation method). The preparation method comprises: combining the (a) carrier, (b) a chelating agent, (c) an anti-inflammatory agent, (d) a thickening agent, (e) a skin conditioning agent, (f) a moisturizing agent, (g) a preservative And (h) a neutralizing agent to prepare the gel composition.

The ingredients may be combined in any order in the preparation process, optionally in the presence of shearing forces or agitation. The individual ingredients are optionally combined with another ingredient to form a plurality of "premix" ingredients prior to forming the gel composition. When preparing the gel composition, the carrier can be added in an incremental manner. The conditions attached to the preparation method can be modified as desired, for example, in relation to temperature, relative humidity, and the like. As will be appreciated by those skilled in the art, the parameters (including temperature, time) attached to the method can be varied based on manufacturing volume and other factors, increasing or decreasing in size under a number of methods.

In a specific embodiment of the method of preparation, a portion of the (a) carrier is first disposed in a container, and (b) a chelating agent and (c) an anti-inflammatory agent are mixed to form a mixture, and d) A thickening agent is incrementally placed into the mixture to form a thickened mixture. In general, the (d) thickening agent is added to the mixture at a rate that is gradually added to avoid agglomeration or agglomeration. The amount of the (a) carrier used in the mixture is varied, but is typically less than half of the total amount of the carrier (a) in the gel composition. When the (d) thickening agent is incrementally added to the mixture, the (d) thickening agent can absorb a portion of the (a) carrier in the mixture, and when (d) the thickening agent is incrementally placed The mixture is sheared or stirred until the (a) carrier is hydrated. Both the mixture and the thickened mixture are typically mixed such that the mixture and the thickened mixture are homogeneous (although the mixture and the thickened mixture are optionally and independently heterogeneous.

In a specific embodiment of these methods of preparation, an additional amount of (a) a carrier and (e) a skin conditioning agent are placed in the thickened mixture to form a first composition. As described above, the (e) skin conditioning agent can include a plurality of matching skin conditioning agents, and such a plurality of skin conditioning agents, typically collectively (or sequentially) when formed into the first composition. Place in the thickened mixture. For example, each skin conditioning agent can be independently placed into the thickened mixture, or each skin conditioning agent can be combined with an additional amount of (a) carrier such that the additional amount of (a) carrier and (e) Skin conditioning agents are commonly placed in the thickened mixture.

Further, in these embodiments of the preparation method, the first composition is heated to a rising temperature for a period of time. The elevated temperature is typically less than (a) the boiling point of the support and the first composition. Typically, the elevated temperature is 50 to 100, or 60 to 90, and 75 to 80 °C. When the (e) skin conditioning agent includes, for example, a cosmetic wax (which may have an elevated melting point temperature), the elevated temperature is often utilized. This period of time is typically greater than 0 to 60, or 5 to 20, or 10 to 15 minutes. After heating the first component to the elevated temperature for a period of time, the first component is typically cooled to a temperature less than the elevated temperature, such as 30 to 60, or 40 to 45 °C. The first composition can be actively cooled to this temperature, or the heating should be suspended so that the first composition reaches this temperature under natural cooling of ambient conditions.

Further, in a specific embodiment of the preparation method, the (g) preservative and the (h) neutralizing agent are placed in the first composition to form the gel composition. Things. The first composition, when the (h) neutralizing agent is placed therein, is typically thickened. Typically, the first component is mixed during the (h) neutralizer addition without any excess air being combined. This mixing can be carried out under inert gas conditions or under vacuum.

In certain embodiments, when (f) the humectant comprises sodium gluconate, either alone or in combination with other humectants, the sodium gluconate is combined with other ingredients to form a gel composition. Previously, it was combined with some (a) carriers.

Further, the present invention provides a method (application method) of applying the gel composition to an ultrasonic program. The method of application includes applying the gel composition to the subject's skin. The gel composition can be applied or wiped onto the skin by any means, and can be rubbed off the skin or applied to/on the skin outside the ultrasonic procedure.

Applying a gel composition to the skin can be performed by any technique. For example, the gel composition can be applied to the skin by the body or applied by others. The gel composition can be dispensed, sprinkled and/or applied to the skin, optionally with the application of an external force to spread or apply the gel composition. In certain embodiments, the substrate can also be in the form of an article to carry or transport the gel composition onto the skin of the subject. These steps can be repeated as many times as desired to achieve the desired benefit.

The gel composition has excellent ultrasonic and lubricating properties, and Especially suitable for ultrasonic programs. In such procedures, the gel composition is applied to an interface between the skin and an ultrasonic probe or transducer and applied to the subject's skin. Sound waves are delivered via the gel composition and can be utilized, for example, for imaging or mapping, or for treating skin conditions. In a particular embodiment, the gel composition can be utilized in an ultrasonic procedure to reduce wrinkles or to improve skin conditions of the subject, for example, the face and/or neck.

Based on the excellent physical properties of the gel composition, the gel composition can be applied while the body is standing or sitting without undesired flow or separation. In contrast, many conventional ultrasonic gels are applied while the subject is lying down horizontally to prevent gravity from causing the conventional ultrasonic gel to produce unwanted flows. Furthermore, the gel composition, based on, is beneficial to the skin.

The following examples are intended to illustrate the present embodiments and are not to be considered as limiting the scope of the embodiments.

example

Example 1: Gel composition

A gel composition was prepared in accordance with the prior embodiments. Table 1 below lists the ingredients used to prepare the gel composition and their relative amounts.

The carrier (first, second and third) is water.

The chelating agent includes sodium EDTA.

Anti-inflammatory agents include dipotassium glycyrrhizinate.

The thickener comprises an acrylic polymer.

Skin Conditioning Agent 1 comprises butylene glycol.

Humectant 1 includes glycerin.

Skin Conditioning Agent 2 comprises a diPEG-18-methyl ether dimethyl decane wax.

Skin Conditioner 3 includes polyethylene glycol (7) glyceryl cocoate.

The preservative comprises a preservative premix of chlorophenyl glyceryl ether/methylparaben in a vehicle comprising a mixture of glycerol and butanol.

The neutralizing agent is triethanolamine.

Skin Conditioner 4 includes Biosaccharide-1.

Humectant 2 includes sodium sodium carboxylate.

In this method, the carrier, chelating agent, and anti-inflammatory agent are combined in a container under agitation. The thickening agent is gradually added to the container until it is hydrated. The carrier (second part), skin conditioning agent 1, moisturizer 1, skin conditioning agent 2, and the skin conditioning agent 3 are placed in the container. While stirring the contents of the container, the container is heated to an elevated temperature of 75 to 80 ° C for about 10 to 15 minutes. The contents of the container are then cooled to about 40 to 45 °C. At this temperature, preservatives and neutralizers are mixed into the contents of the container. Do not incorporate air into it. The carrier (third portion) is combined with the humectant 2 to form a premix, and the premix is placed in the container with agitation together with the skin conditioner 4 to form the gel composition. .

The gel composition had a viscosity of 53,504 centipoise (i.e., 25 ° C), a specific gravity of 1.019, and a pH of 6.30.

The word "including cormprising" or "comprises" is used in its broadest sense to mean and encompass "including"," Contains the concept of "include", "consisting essentially of "consist (ing) essentially of", and "consisting of "consist(ing)". Use "for example", "eg eg", "such as The terms "as" and "including" are used to list the illustrative examples and are not limited to the examples listed. Therefore, "for example" or "such as such as" means "for example, but not limited. The word "or" is used, for example, but not limited to, and encompasses similar or equivalent examples. The word "about" as used herein is used to reasonably encompass or describe by instrumental analysis or sample processing. A small variation of the measured value. Such a small variant may be in the order of ±0~10, ±0~5, or ±0~2.5% of the value. Again, the word "about", Applicable to numerical values with a range of values. Furthermore, the word "about" can also be applied to numerical values without being explicitly stated.

In general, the connection symbol "-" or "dash" __" used in the numerical range herein refers to "to" or "until"; ">" means "above" or "greater than"; "≧" is at least "or" greater than or equal to; "<" is lower than "or less than"; "≦" is "maximum" or "less than or equal to". Each of the aforementioned applications for "patent" or "patent application disclosure" is hereby incorporated by reference in its entirety in its entirety in its entirety in its entirety in its entirety in its entirety in its entirety herein

It is to be understood that the scope of the appended claims is not to be construed as limited or There are changes. Different from the specific features or viewpoints used to describe the embodiments herein. The Markusi group of special, and/or unexpected results, obtained from each of the numbers in each of the Markusi groups, is independent of all other Markusi numbers. Each number of the Markusi group can be used independently or in combination, and it provides sufficient support for the specific embodiments within the scope of the appended claims.

Further, any range and sub-range are singularly or collectively describing a plurality of embodiments of the present embodiments within the scope of the appended claims, and are understood as describing or considering the inclusion of the body and/or partial values. The full range, although such values are not clearly written in the text. It is readily recognized by those skilled in the art that the numerical ranges and sub-ranges are sufficient to describe and enable the various embodiments of the present invention, and such ranges and sub-ranges are further divided into related half and three points. One, one quarter, one fifth, and so on. For example (for demonstration purposes), the range of "0.1~0.9" can be further divided into a smaller one, ie 0.1~0.3, the middle third, ie 0.4-0.6, and more three One or more, that is, 0.7 to 0.9, which are individually or collectively within the scope of the following claims, and which may be individually or collectively attached, and provide sufficient for specific embodiments within the scope of the appended claims. support. In addition, with respect to some words used to define or modify a range, such as "at least", "greater than", "less than", "not more than", and the like, it is to be understood that such words include Sub-range and/or higher or smaller limits. As another example, the range of "at least 10" includes a range of at least 10 to 35 times, a range of 10 to 25 times, a range of 25 to 35 times, etc., and each Each of the sub-ranges is dependent on the individual or collectively and provides sufficient support for the specific embodiments within the scope of the appended claims. Finally, individual numbers within the scope of the disclosure are attached and sufficient support is provided for the specific embodiments within the scope of the appended claims. For example, a range of 1-9, including a number of individual integers, such as 3, and individual numbers containing decimal points (or fractions), such as 4.1, may provide sufficient for specific embodiments within the scope of the appended claims. stand by.

The present invention has been described in an illustrative manner, and it is understood that the naming method used is intended to be within the spirit of the description and not to be construed as limiting. Many modifications and variations of the present invention are possible based on the foregoing teachings. Existing implementations can be implemented in addition to those specifically set forth in the appended claims. The independent subject matter of the scope of rights and the entire combination of the dependent items, whether single or multiple, are clearly understood in this document.

Claims (16)

A gel composition for an ultrasonic program comprising: (a) a carrier in an amount of 70 to 95% by weight (wt%); and (b) a chelating agent in an amount of more than 0 to 0.1% by weight; c) a primary anti-inflammatory agent in an amount greater than 0 to 0.3% by weight; (d) a thickening agent in an amount greater than 0 to 1.0% by weight; (e) a skin conditioning agent in an amount greater than 0 to 25 % by weight; f) a humectant, the content is more than 0 to 25 wt%; (g) a preservative, the content is greater than 0 to 4 wt%; and (h) a neutralizer, the content is greater than 0 to 1 wt%, each of the above contents It is calculated based on the total weight of the gel composition. The gel composition according to claim 1, wherein the (a) carrier is contained in an amount of from 80 to 95% by weight based on the total weight of the gel composition. The gel composition according to claim 1 or 2, wherein the (a) carrier is water. The gel composition of claim 1 or 2, wherein the (f) humectant comprises a first humectant and a second humectant different from the first humectant. The gel composition of claim 4, wherein the first humectant comprises glycerin and the second humectant comprises sodium hyaluronate. The gel composition according to claim 1 or 2, wherein the (g) prevention The humic agent includes a composition of chlorophenesin and methylparaben present in a carrier. The gel composition of claim 1 or 2, wherein the (d) thickening agent comprises an acrylic acid polymer. The gel composition of claim 1 or 2, wherein the (c) anti-inflammatory agent comprises dipotassium glycyrrhizate. The gel composition according to claim 1 or 2, wherein the viscosity at 25 ° C is 30,000 to 120,000 cps. The gel composition according to claim 1 or 2, wherein the pH is 5.7 to 6.6. A method of preparing a gel composition according to claim 1 of the patent application, the method comprising: combining the (a) carrier, (b) a chelating agent, (c) an anti-inflammatory agent, (d) a thickening agent, (e) a skin conditioning agent, (f) a humectant, (g) a preservative; and (h) a neutralizing agent to prepare the gel composition. The method of claim 11, wherein the portion (a) of the carrier is first placed in a container together with (b) a chelating agent and (c) an anti-inflammatory agent to form a mixture under agitation. And the (d) thickener is incrementally placed in the mixture to form a thickened mixture. The method of claim 12, wherein an additional amount of (a) a carrier, and (e) a skin conditioning agent are placed in the thickened mixture to form a first mixture, and wherein the first A composition is heated to an elevated temperature. The method of claim 13, wherein the (g) preservative and the (h) neutralizing agent are placed in the first composition to form the gel composition. A method of applying a gel composition to an ultrasonic procedure comprising applying a gel composition of the first aspect of the patent application to the skin of a subject. The method of claim 15, wherein the main system is standing or sitting.