TW201705965A - β2GPI基因表現抑制RNAi醫藥組合物 - Google Patents

β2GPI基因表現抑制RNAi醫藥組合物 Download PDF

Info

Publication number: TW201705965A
Authority: TW; Taiwan
Prior art keywords: group; compound; alkenyl; carbon atoms; double
Prior art date: 2015-07-15

Application number

TW105122521A

Other languages

English (en)

Chinese (zh)

Inventor

Kazutaka Nagatomo

Kazuhiro Masuda

Minako Kanda

Yoji Yamada

Hiroto Iwai

Tomoyuki Naoi

Original Assignee

Kyowa Hakko Kirin Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-07-15

Filing date

2016-07-15

Publication date

2017-02-16

2016-07-15 Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd

2017-02-16 Publication of TW201705965A publication Critical patent/TW201705965A/zh

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dispersion Chemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

TW105122521A 2015-07-15 2016-07-15 β2GPI基因表現抑制RNAi醫藥組合物 TW201705965A (zh)

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EP3323893A4 (en) *	2015-07-16	2019-03-27	Kyowa Hakko Kirin Co., Ltd.	BETA2GPI GENE EXPRESSION-INHIBITING NUCLEIC ACID COMPLEX
CA2998810A1 (en)	2015-09-17	2017-03-23	Modernatx, Inc.	Compounds and compositions for intracellular delivery of therapeutic agents
SMT202200252T1 (it) *	2015-12-22	2022-07-21	Modernatx Inc	Composti e composizioni per il rilascio intracellulare di agenti
WO2019027009A1 (ja) *	2017-08-02	2019-02-07	協和発酵キリン株式会社	核酸複合体
US11066355B2 (en)	2019-09-19	2021-07-20	Modernatx, Inc.	Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
CN117263882B (zh) *	2023-11-21	2024-02-23	深圳瑞吉生物科技有限公司	一种阳离子脂质化合物、包含其的组合物及应用

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WO2017010573A1 (ja)	2017-01-19

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