TW201609168A - 抗口臭口腔護理組成物 - Google Patents
抗口臭口腔護理組成物 Download PDFInfo
- Publication number
- TW201609168A TW201609168A TW103141551A TW103141551A TW201609168A TW 201609168 A TW201609168 A TW 201609168A TW 103141551 A TW103141551 A TW 103141551A TW 103141551 A TW103141551 A TW 103141551A TW 201609168 A TW201609168 A TW 201609168A
- Authority
- TW
- Taiwan
- Prior art keywords
- zinc
- composition
- oral care
- arginine
- care composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 175
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000004475 Arginine Substances 0.000 claims abstract description 42
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 42
- 150000003839 salts Chemical group 0.000 claims abstract description 18
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 32
- 239000002324 mouth wash Substances 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- 229940051866 mouthwash Drugs 0.000 claims description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 15
- 150000001413 amino acids Chemical class 0.000 claims description 14
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 14
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 10
- 239000011746 zinc citrate Substances 0.000 claims description 10
- 235000006076 zinc citrate Nutrition 0.000 claims description 10
- 229940068475 zinc citrate Drugs 0.000 claims description 10
- 150000003752 zinc compounds Chemical class 0.000 claims description 9
- 239000011787 zinc oxide Substances 0.000 claims description 9
- 235000014692 zinc oxide Nutrition 0.000 claims description 9
- 206010006326 Breath odour Diseases 0.000 claims description 8
- 210000000214 mouth Anatomy 0.000 claims description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 7
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 7
- 239000000606 toothpaste Substances 0.000 claims description 7
- 229940034610 toothpaste Drugs 0.000 claims description 7
- 239000011592 zinc chloride Substances 0.000 claims description 7
- 235000005074 zinc chloride Nutrition 0.000 claims description 7
- 239000011576 zinc lactate Substances 0.000 claims description 7
- 235000000193 zinc lactate Nutrition 0.000 claims description 7
- 229940050168 zinc lactate Drugs 0.000 claims description 7
- 239000007937 lozenge Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 6
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 5
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 3
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 235000015218 chewing gum Nutrition 0.000 claims description 3
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 claims description 3
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 claims description 3
- 239000004246 zinc acetate Substances 0.000 claims description 3
- 235000013904 zinc acetate Nutrition 0.000 claims description 3
- 239000011667 zinc carbonate Substances 0.000 claims description 3
- 235000004416 zinc carbonate Nutrition 0.000 claims description 3
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 3
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 claims description 3
- 239000011670 zinc gluconate Substances 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- 229940032991 zinc picolinate Drugs 0.000 claims description 3
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 3
- 229940057977 zinc stearate Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- 229940118257 zinc undecylenate Drugs 0.000 claims description 3
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 3
- JNPQFTCBVDSMDO-UHFFFAOYSA-L zinc;2,3-dihydroxypropanoate Chemical compound [Zn+2].OCC(O)C([O-])=O.OCC(O)C([O-])=O JNPQFTCBVDSMDO-UHFFFAOYSA-L 0.000 claims description 3
- MCOGTQGPHPAUJN-UHFFFAOYSA-L zinc;2-hydroxyacetate Chemical compound [Zn+2].OCC([O-])=O.OCC([O-])=O MCOGTQGPHPAUJN-UHFFFAOYSA-L 0.000 claims description 3
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 claims description 3
- NHVUUBRKFZWXRN-UHFFFAOYSA-L zinc;pyridine-2-carboxylate Chemical compound C=1C=CC=NC=1C(=O)O[Zn]OC(=O)C1=CC=CC=N1 NHVUUBRKFZWXRN-UHFFFAOYSA-L 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 2
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 229960001939 zinc chloride Drugs 0.000 claims description 2
- 229960001296 zinc oxide Drugs 0.000 claims description 2
- 229940077935 zinc phosphate Drugs 0.000 claims description 2
- GAWWVVGZMLGEIW-GNNYBVKZSA-L zinc ricinoleate Chemical compound [Zn+2].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O GAWWVVGZMLGEIW-GNNYBVKZSA-L 0.000 claims description 2
- 229940100530 zinc ricinoleate Drugs 0.000 claims description 2
- 150000001483 arginine derivatives Chemical class 0.000 claims 1
- -1 Zn2+ ions Chemical class 0.000 description 19
- 235000001014 amino acid Nutrition 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 8
- 210000003296 saliva Anatomy 0.000 description 8
- 235000003599 food sweetener Nutrition 0.000 description 7
- 239000003765 sweetening agent Substances 0.000 description 7
- 239000002562 thickening agent Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229920002125 Sokalan® Polymers 0.000 description 6
- 239000003082 abrasive agent Substances 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- 239000004471 Glycine Substances 0.000 description 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 5
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
- 239000004472 Lysine Substances 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 235000003704 aspartic acid Nutrition 0.000 description 5
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 5
- 235000014304 histidine Nutrition 0.000 description 5
- 239000003906 humectant Substances 0.000 description 5
- 235000018977 lysine Nutrition 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- 150000003464 sulfur compounds Chemical class 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 239000010455 vermiculite Substances 0.000 description 5
- 229910052902 vermiculite Inorganic materials 0.000 description 5
- 235000019354 vermiculite Nutrition 0.000 description 5
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000003086 colorant Substances 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 235000015424 sodium Nutrition 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 230000002272 anti-calculus Effects 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 239000011775 sodium fluoride Substances 0.000 description 3
- 235000013024 sodium fluoride Nutrition 0.000 description 3
- 229960000414 sodium fluoride Drugs 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
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- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
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- 239000005770 Eugenol Substances 0.000 description 2
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- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
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- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
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- 150000005215 alkyl ethers Chemical class 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
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- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Cosmetics (AREA)
Abstract
一種口腔護理組成物，其包含：呈游離或鹽形式之精胺酸以及鋅離子，其中該鋅離子係在該組成物中以0.0001莫耳/100克至0.0150莫耳/100克之濃度存在，其以該組成物之總重為基準。
Description
一種口腔護理組成物，其包含：呈游離或鹽形式之精胺酸以及鋅離子，其中該鋅離子係在該組成物中以0.0001莫耳/100克至0.0150莫耳/100克之濃度存在，其以該組成物之總重為基準。
在口腔中主要造成口臭因素中之一係存在於軟及硬口腔組織之細菌。手動刷牙及沖洗幫助移除細菌，但其終究於一段時間週期內再群聚。
鋅離子係藉由結合細菌以及降低成長相之速度，導致細胞分裂與再群聚更慢而作為抑菌劑。口腔護理產品中之鋅鹽已知與在壞口氣中發現之硫化合物反應。例如，氧化鋅與硫化氫之反應製造了無臭的硫化鋅。
然而，在先前技藝中仍有一個對於口腔護理組成物之需求，該組成物具有在降低口腔臭味之效率甚至大於先前含鋅離子之組成物。
本發明之第一觀點係提供一種口腔護理組成物，其包含：呈游離或鹽形式之精胺酸；以及鋅離子，其中該鋅離子係在該組成物中以0.0001莫耳/100克至0.015莫耳/100克之濃度存在，其以該組成物之總重為基準。
視情況地，該鋅離子係在該組成物中以0.00025莫耳/100克至0.005莫耳/100克之濃度存在，其以該組成物之總重為基準。
視情況地，該鋅離子係在該組成物中以0.0004莫耳/100克至0.0015莫耳/100克之濃度存在，其以該組成物之總重為基準。
視情況地，該鋅離子係在該組成物中以0.0005莫耳/100克至0.001莫耳/100克之濃度存在，其以該組成物之總重為基準。
視情況地，該鋅離子係在該組成物中以0.00052莫耳/100克至0.00062莫耳/100克之濃度而存在，其以該組成物之總重為基準。
視情況地，該精胺酸係在該組成物中以0.1重量%至1重量%之濃度而存在，其以該組成物之總重為基準。
視情況地，該精胺酸係在該組成物中以0.5重量%至0.8重量%之濃度而存在，其以該組成物之總重為基準。
視情況地，該鋅離子係藉由但不限於氧化鋅、乳酸鋅、氯化鋅、檸檬酸鋅、乙酸鋅、硼酸鋅、丁酸鋅、碳酸鋅、甲酸鋅、葡萄糖酸鋅、甘油酸鋅、羥乙酸鋅、磷酸鋅、吡啶甲酸鋅(zinc picolinate)、丙酸鋅(zinc proprionate)、水楊酸鋅、矽酸鋅、硬脂酸鋅、酒石酸鋅、十一烯酸鋅、蓖麻油酸鋅、硝酸鋅、硫酸鋅或其混合物而提供。
視情況地，該鋅離子係藉由氧化鋅而提供。
視情況地，該鋅離子係藉由乳酸鋅而提供。
視情況地，該鋅離子係藉由氯化鋅而提供。
視情況地，該鋅離子係藉由檸檬酸鋅而提供。
視情況地，該精胺酸係作為游離精胺酸而存在。
視情況地，該精胺酸係作為精胺酸重碳酸鹽而存在。
視情況地，該精胺酸係作為一具有2-4個胺基酸單元之胜肽中至少一個為精胺酸而存在。
視情況地，該組成物進一步包含一或多種選自研磨劑、稀釋劑、加成重碳酸鹽、pH改質劑、界面活性劑、泡沫調節劑、增稠劑、保溼劑、甜味劑、風味劑、顏料、抗菌劑、抗齲齒劑、抗結石劑或牙石控制劑、美白劑及其混合物之藥劑。
視情況地，該組成物係牙膏、凝膠、漱口水、漱口劑(mouthrinse)、喉錠(lozenge)、噴霧劑、口香糖、錠劑或薄膜。
視情況地，該組成物係漱口水。
視情況地，該組成物係牙膏。
在第二觀點中，本發明係提供一種在患者口腔中降低口臭之方法，該方法包含施加本發明之口腔護理組成物至該口腔中。
在第三觀點中，本發明係提供一種在口腔護理組成物中呈游離或鹽形式之精胺酸與鋅離子之組合於降低口臭之用途，其中該鋅離子係在該組成物中以0.0001莫耳/100克至0.015莫耳/100克之濃度而存在，其以該組成物之總重為基準。
以下較佳具體實例之詳述本質上僅為例示的，且決不是意欲限制本發明、其應用或用途。
作為貫穿全文之使用，範圍係使用於作為描述在該範圍中之各個及每個數值的簡寫。可選擇在該範圍中之任一數值作為該範圍之端點。引用之全部參考文獻係藉此藉由全文參照併入本文中。在本揭示內容中之定義與所引用參考文獻之定義衝突情形下，以本揭示內容為準。
除非另有指示，否則本文提及之所有組成的百分比係總組成之重量比。除非另有指示，否則本文提及之“ppm”(每百萬之份數，parts per million)係指重量比之ppm。除非另有指示，否則本文提及之所有比率係指重量比。
本發明已發現包含鋅離子與精胺酸組合之口腔護理組成物顯示在揮發性硫化合物(VSCs)的減少程度中令人驚訝地高效率，其係與單獨含有鋅離子或者精胺酸之組成物相比。
本發明係提供一種口腔護理組成物，其包含：呈游離或鹽形式之精胺酸；以及鋅離子(Zn2+離子)，其中該鋅離子係在該組成物中以0.0001莫耳/100克至0.015莫耳/100克之濃度存在，其以該組成物之總重為基準。
在某些具體實例中，鋅離子係在該組成物中以選自由0.00025莫耳/100克至0.005莫耳/100克、0.0004莫耳/100克至0.0015莫耳/100克、0.0005莫耳/100克至0.001莫耳/100克以及0.00052莫耳/100克至0.00062莫耳/100克所組成之群組的濃度存在，其以該組成物之總重為基準。
在某些具體實例中，鋅離子係藉由包含但不限於氧化鋅、乳酸鋅、氯化鋅、檸檬酸鋅、乙酸鋅、硼酸鋅、丁酸鋅、碳酸鋅、甲酸鋅、葡萄糖酸鋅、甘油酸鋅、羥乙酸鋅、磷酸鋅、吡啶甲酸鋅、丙酸鋅、水楊酸鋅、矽酸鋅、硬脂酸鋅、酒石酸鋅、十一烯酸鋅、磷酸鋅、蓖麻油酸鋅、硝酸鋅、硫酸鋅或其混合物之鋅化合物而提供。
在某些具體實例中，鋅離子係藉由氧化鋅、乳酸鋅、氯化鋅、檸檬酸鋅或其混合物而提供。
在某些具體實例中，鋅離子係藉由氧化鋅而提供。在某些具體實例中，鋅離子係藉由乳酸鋅而提供。在某些具體實例中，鋅離子係藉由氯化鋅而提供。在某些具體實例中，鋅離子係藉由檸檬酸鋅而提供。
在某些具體實例中，精胺酸係在組成物中以0.1重量%至1重量%或0.5重量%至0.8重量%之濃度而存在，其以該組成物之總重為基準。
在某些具體實例中，精胺酸係作為游離精胺酸而存在。在某些具體實例中，精胺酸係作為鹽而存在。
在某些具體實例中，當精胺酸係呈鹽形式，其可能為包括但不限於精胺酸重碳酸鹽、精胺酸氫氧化物、精胺酸碳酸鹽、精胺酸磷酸鹽及其混合物之鹽。
由於呈游離或鹽形式之精胺酸與鋅離子之組合於減少揮發性硫化合物(VSCs)之令人驚訝地能力本質，本發明之另一具體實例係一口腔護理組成物，其實質上係由精胺酸與鋅離子之組合所組成。
該組成物亦可含有一口腔可接受載劑。可使用任何習慣的載劑，其係典型地用於製造口腔護理組成物。在某些具體實例中，該口腔護理組成物係牙膏、凝膠、漱口水、漱口劑(mouthrinse)、喉錠(其可為可溶或可嚼的)、噴霧劑、口香糖、錠劑或薄膜(其可全部或部份地可溶或不可溶的)。
在某些具體實例中，該口腔護理組成物係漱口水。在某些具體實例中，該口腔護理組成物係牙膏。
在某些具體實例中，該口腔護理組成物進一步可包含一或多種選自研磨劑、稀釋劑、額外之碳酸氫鹽、pH改質劑、界面活性劑、泡沫調節劑、增稠劑、保溼劑、甜味劑、風味劑、顏料、抗菌劑、抗齲齒劑、抗結石或牙石控制劑及其混合物之用劑。
在某些具體實例中，特別是(但不限於)那些其中該口腔護理組成物係牙膏的具體實例，本發明之組成物可進一步包含一研磨劑。
可使用之研磨劑包含矽石研磨劑，像是沉澱或水合矽石，其具有高至約20微米之平均粒度，像是Zeodent 105及Zeodent 114銷售自J.M.Huber Chemicals Division，Havre de Grace，Md.21078；或者Sylodent 783銷售自W.R.Grace & Company之Davison Chemical Division。亦可包含研磨劑，像是Sorbosil AC 43來自PQ Corporation。其他有用之牙粉研磨劑包含氧化鋁、矽酸鋁、鍛燒氧化鋁、皂土或其他矽質材料、不溶性磷酸鹽及其混合物。
研磨劑可以5至30重量%(以該組成物之重量為基準)之量，視情況地10至20重量%(以該組成物之重量為基準)之量存在。
在某些具體實例中，特別是(但不限於)那些其中該口腔護理組成物係漱口水或漱口劑(mouthrinse)的具體實例，該組成物可為無研磨劑。
在某些具體實例中，本發明之口腔護理組成物可包含至少一額外之碳酸氫鹽(亦即除了在某些具體實例中可存在之任何精胺酸碳酸氫鹽之外)，其有用於例如賦予牙齒及齒齦“清潔感”，因為二氧化碳的起泡與釋放。可使用任何的口腔可接受碳酸氫鹽，其包含但不限於鹼金屬碳酸氫鹽，如碳酸氫鈉及碳酸氫鉀、碳酸氫銨及其類似物。一或多種額外之碳酸氫鹽係視情況地以總量的約0.1重量%至約50重量%(例如約1重量%至20重量%)之該組成物的總重存在。
在某些具體實例中，本發明之組成物可包含至少一pH改質劑。這樣的用劑包含降低pH之酸化劑、提高pH之鹼化劑以及控制pH於所欲範圍之間的緩衝劑。例如，可包含一或多種選自酸化、鹼化及緩衝劑之化合物以提供pH2至10，或者在不同的說明性具體實例中，2至8、3至9、4至8、5至7、6至10、7至9等等。可使用之任何口腔可接受pH改質劑，包括但不限於羧酸、磷酸及磺酸、酸鹽(例如，檸檬酸一鈉、檸檬酸二鈉、蘋果酸一鈉等等)、鹼金屬氫氧化物像是氫氧化鈉、碳酸鹽像是碳酸鈉、重碳酸鹽(除了可能存在於某些具體實例中之任何精胺酸重碳酸鹽外)、二碳酸氫酸鹽、硼酸鹽、矽酸鹽、磷酸鹽(例如，磷酸一鈉、磷酸三鈉)、咪唑及其類似物。一或多種pH改質劑係視情況地以有效維持組成物於口腔可接受pH範圍中之總量而存在。
在還要進一步之具體實例中，本發明之組成物可包含至少一界面活性劑。可使用任何口腔可接受界面活性劑，其中大部分係陰離子、
非離子或兩性的。合適的陰離子界面活性劑包含但不限於C8-20烷基硫酸鹽之水溶性鹽類、C8-20脂肪酸之磺酸化單甘油酯、肌胺酸鹽、牛磺酸鹽及其類似物。此些或其他種類之說明性實例包含月桂基硫酸鈉、椰子單甘油酯磺酸鈉、月桂基肌胺酸鈉、月桂基羥乙磺酸鈉(sodium lauryl isoethionate)、月桂醇聚氧乙烯醚羧酸鈉(sodium laureth carboxylate)及十二基苯磺酸鈉。合適的非離子界面活性劑包含但不限於泊洛沙姆(poloxamers)、聚氧乙烯山梨糖醇酯、脂肪醇乙氧化物、烷基酚乙氧化物、三級胺氧化物、三級膦氧化物、二烷基亞碸及其類似物。合適的兩性界面活性劑包含但不限於C8-20脂族二級及三級胺之衍生物，其具有陰離子基，像是羧酸根、硫酸根、磺酸根、磷酸根或膦酸根。亦可使用甜菜鹼，其合適的實例係椰子醯胺丙基甜菜鹼(cocoamidopropyl betaine)。一或多種界面活性劑係視情況地以總量之約0.01重量%至約10重量%，例如約0.05重量%至約5重量%或約0.1重量%至約2重量%之組成物總重存在。
在某些具體實例中，本發明之組成物可包含至少一泡沫調節劑，其有用例如於增加攪拌中組成物產生泡沫之數量、厚度或穩定度。可使用任何口腔可接受泡沫調節劑，其包含但不限於聚乙二醇(PEGs)，亦已知為聚氧乙烯。高分子量PEG係合適的，其包含那些具有200,000至7,000,000，例如500,000至5,000,000或者1,000,000至2,500,000之平均分子量者。一或多種PEG係視情況地以總量之約0.1重量%至約10重量%，例如約0.2重量%至約5重量%或者約0.25重量%至約2重量%之組成物的總重存在。
在某些具體實例中，特別是(不限於)那些其中口腔護理組成物係漱口水或漱口劑之具體實例，該組成物可不含泡沫調節劑。
在某些具體實例中，本發明之組成物可包含至少一增稠劑，其有用例如於賦予組成物所欲之稠度及/或口感。可使用任何口腔可接受增稠劑，包含但不限於卡波姆(carbomers)(亦已知為羧基乙烯基聚合物)，角叉
菜膠(亦已知為愛爾蘭苔且更特別是-角叉菜膠)，纖維素聚合物像是羥乙基纖維素、羧甲基纖維素(CMC)及其鹽類(例如CMC鈉)，天然膠像是刺梧桐膠、三仙膠、阿拉伯膠及黃蓍膠、膠體狀之矽酸鎂鋁、矽酸膠極其類似物。較佳增稠或膠化劑種類包含與新戊四醇的烷基醚或蔗糖的烷基醚交聯之丙烯酸的均聚物，或者卡波姆之種類。卡波姆係可商購獲自B.F.Goodrich，為Carbopol®系列。特佳之卡波姆包含Carbopol 934、940、941、956、974P及其混合物。亦可使用矽石增稠劑，像是Hi-Sil®DT 267(來自PPG Industries)。一或多種增稠劑係視情況地以總量之約0.01重量%至15重量%，例如約0.1重量%至約10重量%或約0.2重量%至約5重量%之該組成物的總重存在。
在某些具體實例中，本發明之組成物可包含至少一黏度改質劑，其有用例如於幫助抑制組份的沉降或分離，或者在液體組成物的攪拌過程中促進再分散性。可使用任何口腔可接受黏度改質劑，其包含但不限於礦物油、石蠟脂、黏土與有機改質黏土、矽石及其類似物。一或多種黏度改質劑係視情況地以總量之約0.01重量%至約10重量%，例如約0.1重量%至約5重量%之該組成物的總重存在。
在某些具體實例中，本發明之組成物可包含至少一保溼劑。可使用任何口腔可接受保溼劑，其包含但不限於多元醇像是甘油、山梨醇(視情況地為70重量%在水中之溶液)、木糖醇或低分子量聚乙二醇(PEGs)。最多的保溼劑亦作用為甜味劑。一或多種保溼劑係視情況地以總量之約1重量%至約70重量%，例如約1重量%至約50重量%、約2重量%至約25重量%或約5重量%至約15重量%之該組成物的總重存在。
在某些具體實例中，本發明之組成物可包含至少一甜味劑，其有用例如於提高該組成物的味道。可使用任何口腔可接受天然或人工甜味劑，其包含但不限於葡萄糖、蔗糖、麥芽糖、糊精、乾轉化糖(dried invert
sugar)、甘露糖、木糖、核糖、果糖(fructose)、果糖(levulose)、半乳糖、玉米糖漿(其包含高果糖玉米糖漿及玉米糖漿固體)、部分水解澱粉、氫化澱粉水解產物、山梨醇、甘露醇、木糖醇、麥芽糖醇、異麥芽酮糖醇(isomalt)、阿斯巴甜、紐甜(neotame)、糖精及其鹽(像是糖精鈉)、以二胜肽為基質之強烈甜味劑、賽克拉美(cyclamates)及其類似物。一或多種甜味劑係視情況地以強烈取決於所選擇之特別甜味劑的總量，且典型為0.005重量%至5重量%之該組成物的總重、視情況地0.005重量%至0.2重量%、進一步視情況地0.05重量%至0.1重量%之該組成物的總重存在。
在某些具體實例中，本發明之組成物可包含至少一風味劑，其有用例如於增進該組成物之味道。可使用任何口腔可接受天然或合成風味劑，其包含但不限於茶味(tea flavours)(像是Cool Jasmine Tea Flavour)、香草醛、鼠尾草、馬鬱蘭、洋芹油、綠薄荷油、桂皮油、冬青油(甲基水楊酸酯)、薄荷油、丁香油、月桂油、大茴香油、桉油、橘皮油、果油及包含那些取自檸檬、橙、酸橙、葡萄柚、杏桃、香蕉、葡萄、蘋果、草莓、櫻桃、鳳梨等等之精油、豆和坚果衍生的香料(像是咖啡、可可、可樂果(cola)、落花生、杏仁等等)、經吸附及包覆之風味劑及其類似物。亦包含於此處風味劑之中的為提供嘴中香味及/或包含降溫或暖熱效果的其他知覺效果之組份。這樣的組份說明性地包含薄荷醇、乙酸薄荷酯、乳酸薄荷酯、樟腦、桉油、桉油醇、茴香腦、丁香酚、桂皮、噁酮(oxanone)、α-紫羅蘭酮、丙烯基乙基愈創木酚(propenyl guaiethol)、百里酚、沈香醇、苯甲醛、桂皮醛、N-乙基-p-薄荷烷-3-甲醯胺(N ethyl-p-menthan-3-carboxamine)、N,2,3-三甲基-2-異丙基丁醯胺、3-(1-薄荷氧基)丙-1,2-二醇、桂皮醛甘油縮醛(cinnamaldehyde glycerol acetal，CGA)、薄荷酮甘油縮醛(menthone glycerol acetal，MGA)及其混合物。一或多種風味劑係視情況地以總量之約0.01重量%至約5重量%，例如約0.03重量%至約2.5重量%、視情況地約0.05重量%至
約1.5重量%、進一步視情況地約0.1重量%至約0.3重量%之該組成物的總重存在。
本發明之組成物可包含至少一著色劑。此處著色劑包含顏料、染料、色澱及賦予特別光澤或反射性之用劑，像是珠光劑。可使用任何口腔可接受著色劑，其包含但不限於滑石、雲母、碳酸鎂、碳酸鈣、矽酸鎂、矽酸鎂鋁、矽石、二氧化鈦、氧化鋅、紅色、黃色、棕色及黑色氧化鐵、亞鐵氰化鐵銨、錳紫、群青、雲母鈦(titaniated mica)、氧氯化鉍(III)及其類似物。一或多種著色劑係視情況地以總量之約0.001重量%至約20重量%，例如約0.01重量%至約10重量%或約0.1重量%至約5重量%之該組成物的總量存在。
本發明之組成物視情況地包含一抗菌或防腐劑，像是洛赫西定(hlorhexidine)、三氯沙、四級銨化合物(例如氯化苄烷銨)、對羥苯甲酸酯類像是對羥苯甲酸甲酯、對羥苯甲酸丙酯；或者一漂白劑，像是過氧化物及氧化還原酶酵素。一或多種抗菌或防腐劑係視情況地在組成物中以總量之約0.01重量%至約0.5重量%、視情況地約0.05重量%至約0.1重量%之該組成物的總重存在。
在某些具體實例中，組成物可包含一氯化物離子源。氯化物離子源包含但不限於：氟化亞錫、氟化鈉、氟化鉀、單氟磷酸鉀、單氟磷酸鈉、單氟磷酸銨、氟矽酸鈉、氟矽酸銨、氟化胺像是奥拉氟(olaflur)(N'-十八基三亞甲基二胺-N,N,N'-參(2-乙醇)-二氫氟化物)、氟化銨及其組合物。在某些具體實例中，氟化物離子源包含氟化亞錫、氟化鈉、氟化胺、單氟磷酸鈉和其混合物。在某些具體實例中，本發明之口腔護理組成物亦可含有一氟化物離子或提供氟之組份的來源，其以足以供應約50至約5000ppm氟化物離子，例如約100至約1000、約200至約500或約250ppm氟化物離子之量。氟化物離子源可以約0.001重量%至約10重量%、例如約0.003重量%至約5重
量%、0.01重量%至約1重量%，或約0.05重量%之程度添加至本發明之組成物中。然而，可理解提供適當程度之氟化物離子的氟化物鹽重量將基於鹽中相反離子的重量而明顯不同，以及本發明所屬技術領域中具有通常知識者可容易地決定這樣的數量。較佳的氟化物鹽可為氟化鈉。
本發明之組成物視情況地包含唾液刺激劑，其有用例如於改善口腔乾燥。可使用任何口腔可接受唾液刺激劑，其包含但不限於食物酸類，像是檸檬酸、乳酸、蘋果酸、琥珀酸、抗壞血酸、己二酸、富馬酸和酒石酸，及其混合物。一或多種唾液刺激劑視情況地以刺激唾液的有效總量而存在。
本發明之組成物視情況地併入一或多種進一步之抗敏感劑，例如鉀鹽類，像是硝酸鉀、碳酸氫鉀、氯化鉀、檸檬酸鉀及草酸鉀；辣椒鹼；丁香酚；鍶鹽；氯化物鹽及其組合。這樣的用劑可以有效量例如約1重量%至約20重量%(以該組成物之總重為基準)加入，其取決於所選之用劑。本發明之組成物亦可在施加至牙齒時藉由阻斷牙本質小管(dentin tubules)而使用於治療過敏。
在某些具體實例中，本發明之組成物進一步包含一抗氧化劑。可使用任何口腔可接受抗氧化劑，其包含丁基羥基甲氧苯(BHA)、二丁基羥基甲苯(BHT)、維生素A、類胡蘿蔔素、維生素E、類黃酮類、多紛類、抗壞血酸、草本抗氧化劑、葉綠素、褪黑激素及其混合物。
本發明之組成物可額外視情況地包含一牙石控制(抗結石劑)劑如下而提供。本文有用的那些牙石控制劑包含特定藥劑之鹽類，其包含鹼金屬和銨鹽。該等藥劑包含：磷酸鹽和聚磷酸鹽，聚胺基丙烷磺酸(AMPS)，聚烯烴磺酸鹽，聚烯烴磷酸鹽，二膦酸鹽像是氮雜環烷-2,2-二磷酸鹽(例如氮雜環庚烷_2,2-二膦酸)、N-甲基氮雜環戊烷-2,3-二膦酸、乙烷-1-羥基-1,1-二膦酸鹽(EHDP)及乙烷-1-胺基-1,1-二膦酸鹽，以及膦燒
烴羧酸(phosphonoalkane carboxylic acids)。有用的無機磷酸鹽和聚磷酸鹽包括單鹼價(monobasic)、二鹼價(dibasic)和三鹼價(tribasic)磷酸鈉，三聚磷酸鈉，四聚磷酸鈉，三偏磷酸鈉，六偏磷酸鈉，及其混合物。其他有用之牙石控制劑包含聚羧酸鹽聚合物以及聚乙烯基甲基醚/順丁烯二酐(PVM/MA)共聚物，像是GANTREZ®。
在某些具體實例中，本發明之組成物進一步包含一營養素。合適的營養素包括維生素，礦物質，胺基酸，及其混合物。維生素包括維生素C和D、硫胺素、核黃素、泛酸鈣、菸鹼酸、葉酸、菸鹼醯胺、吡哆醇、氰鈷胺、對胺基苯甲酸、生物類黃酮、及其混合物。營養補充劑包括胺基酸(像是L-色胺酸、L-離胺酸、甲硫胺酸、羥丁胺酸、左卡尼汀(levocarnitine)和L-肉鹼)，親脂劑(像是膽鹼、肌醇，甜菜鹼和亞麻油酸)，及其混合物。
本發明亦提供一種在患者口腔中降低口臭之方法，該方法包含施加一本發明之口腔護理組成物至該口腔中。
本發明係提供一種在口腔護理組成物中呈游離或鹽形式之精胺酸與鋅離子之組合於降低口臭之用途，其中該鋅離子係在該組成物中以0.00010莫耳/100克至0.0150莫耳/100克之濃度存在，其以該組成物之總重為基準。
在此處所描述之實驗中，揮發性硫化合物(VSCs)係藉由將全部唾液(85%)、去離子水(10%)及氫硫乙酸鹽(thioglicallate)流體(5%)介質在37℃下培養過夜(至少16小時)而產生。
為比較不同活性物在VSCs程度之功效，在調查中之活性物
係在37℃培養過夜之前添加至唾液/水/氫硫乙酸鹽流體介質混合物。
在以下實例中，在調查中0.1毫升之含有活性物(或活性物之組合物)的漱口水調配物係在一容器中與3毫升之全部唾液/水/氫硫乙酸鹽流體(FTG)介質混合物(如上述)混合，以及允許該混合物在37℃下培養過夜(至少16小時)。
藉由不同混合物製造之揮發性硫化合物的數量係使用氣相層析法與硫偵測器藉由量測在該混合物上面之頂部空間中的VSCs濃度而測定。VSCs之下降百分比係藉由量測在含有唾液/水/FTG與活性物之混合物的小瓶子頂部空間中之VSCs，以及比較此結果與單獨的唾液/水/FTG之混合物(控制組)而計算。(該結果係顯示於實例1至5中)
在以下各個實例中，漱口水調配物含有不同鋅化合物，其呈如表1中所示之濃度。表1A提供安慰劑組成物。各測試變體係藉由添加活性物以及調整水以達到所欲濃度而製備。
其中存在精胺酸(或另一胺基酸)，胺基酸在漱口水調配物中之濃度係0.8重量%。
為了比較，亦評估不含精胺酸或鋅之安慰劑漱口水調配物之減少VSCs功效。此些比較調配物亦以0.1毫升之數量而使用。
在此實例中，含有不同鋅化合物、具有及無精胺酸之漱口水調配物係使用如上述之實驗方案而評估。該結果係顯示於以下表2中。
由此些結果可見添加精胺酸至含有鋅離子之漱口水調配物顯著地增加該漱口水調配物之VSC減少特性。
有不同種類之胺基酸，其基於極性與pH。例如，天門冬酸係酸性極性胺基酸以及甘胺酸係中性非極性胺基酸。精胺酸、組胺酸及離胺酸係鹼性極性胺基酸。測試組胺酸及離胺酸以測定如上顯示之包含精胺酸與鋅離子組合之組成物的功效是否包含鋅離子與其他鹼性極性胺基酸組合之組成物亦顯示(參見以下實例2及3)。測試天門冬酸及甘胺酸係為測定是否上述影響亦會見於鋅離子與除了“鹼性極性”胺基酸以外之種類的胺基酸之組合(參見以下實例4及5)。
在此實例中，含有不同鋅化合物、含有及不含組胺酸之漱口水調配物係使用如上述之實驗方案而評估。該結果係顯示於以下表3中。
在此實例中，含有不同鋅化合物、含有及不含離胺酸之漱口水調配物係使用如上述之實驗方案而評估。該結果係顯示於以下表4中。
在此實例中，含有不同鋅化合物、具有及無天門冬酸之漱口水調配物係使用如上述之實驗方案而評估。該結果係顯示於以下表5中。
在此實例中，含有不同鋅化合物、含有及不含甘胺酸之漱口水調配物係使用如上述之實驗方案而評估。該結果係顯示於以下表6中。
自上述實例2至5可驚訝地見到精胺酸與鋅離子之組合物的高效率不會為鋅離子與任一胺基酸(組胺酸、離胺酸、天門冬酸或甘胺酸)之組合物所分享。
Claims (18)
- 一種口腔護理組成物，其包含：a.呈游離或鹽形式之精胺酸；以及b.鋅離子，其中該鋅離子係在該組成物中以選自由0.0001莫耳/100克至0.015莫耳/100克、0.00025莫耳/100克至0.005莫耳/100克、0.0004莫耳/100克至0.0015莫耳/100克、0.0005莫耳/100克至0.001莫耳/100克以及0.00052莫耳/100克至0.00062莫耳/100克所組成之群組的濃度存在，其以該組成物之總重為基準。
- 如申請專利範圍第1項之口腔護理組成物，其中該鋅離子係在該組成物中以0.00025莫耳/100克至0.005莫耳/100克之濃度存在，其以該組成物之總重為基準。
- 如申請專利範圍第1或2項之口腔護理組成物，其中該鋅離子係在該組成物中以0.0004莫耳/100克至0.0015莫耳/100克之濃度存在，其以該組成物之總重為基準。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該鋅離子係在該組成物中以0.0005莫耳/100克至0.001莫耳/100克之濃度存在，其以該組成物之總重為基準。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該鋅離子係在該組成物中以0.00052莫耳/100克至0.00062莫耳/100克之濃度存在，其以該組成物之總重為基準。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該精胺酸係在該組成物中以0.1重量%至1重量%之濃度存在，其以該組成物之總重為基準。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該精胺酸係在該組成物中以0.5重量%至0.8重量%之濃度而存在，其以該組成物之總重為基準。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該鋅離子係藉由至少一選自氧化鋅、乳酸鋅、氯化鋅、檸檬酸鋅、乙酸鋅、硼酸鋅、丁酸鋅、碳酸鋅、甲酸鋅、葡萄糖酸鋅、甘油酸鋅、羥乙酸鋅、磷酸鋅、吡啶甲酸鋅(zinc picolinate)、丙酸鋅(zinc proprionate)、水楊酸鋅、矽酸鋅、硬脂酸鋅、酒石酸鋅、十一烯酸鋅、磷酸鋅、蓖麻油酸鋅、硝酸鋅及硫酸鋅之鋅化合物提供。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該鋅離子係藉由一選自由氧化鋅、乳酸鋅、氯化鋅及檸檬酸鋅所組成之群組的鋅化合物提供。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該精胺酸係作為游離精胺酸而存在。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該精胺酸係作為一選自由精胺酸碳酸氫鹽、精胺酸氫氧化物、精胺酸碳酸鹽、精胺酸磷酸鹽及其混合物所組成之群組的精胺酸鹽而存在。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該精胺酸係存在於2-4個胺基酸胜肽中。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該組成物進一步包含一口腔可接受載劑.
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該組成物係牙膏、凝膠、漱口水、漱口劑(mouthrinse)、喉錠(lozenge)、噴霧劑、口香糖、錠劑或薄膜。
- 如上述申請專利範圍中任一項之口腔護理組成物，其中該組成物係漱口水。
- 如申請專利範圍第1-14項中任一項之口腔護理組成物，其中該組成物係牙膏。
- 一種在個體口腔中降低口臭之方法，該方法包含施加如申請專利範圍第1-16項中任一項之口腔護理組成物至該口腔中。
- 一種如申請專利範圍第1-16項中任一項之口腔護理組成物之用途，其係製造用於降低口臭之藥劑。
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| CN109122687B (zh) * | 2018-08-25 | 2022-01-18 | 浙江工业大学 | 乙醇酸盐配合物杀菌剂及其应用 |
| CN113226478A (zh) | 2018-12-21 | 2021-08-06 | 高露洁-棕榄公司 | 锌-精氨酸-卤化物络合物 |
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| CN112675260A (zh) * | 2020-12-30 | 2021-04-20 | 江西省科学院应用化学研究所 | 一种抑制口臭的平卧菊三七含片及其制备方法 |
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| CA2927619A1 (en) | 2015-06-25 |
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