TW201404316A - Tobacco composition for oral using - Google Patents

Abstract

The present invention provides a tobacco composition for oral using, in which the blend ratio of the tobacco material is larger than 0.5 wt% and less than 6.0 wt%, the particulate object of tobacco material constituting the said tobacco composition for oral using, having a particle diameter larger than 0.212mm by applying sieve classification.

Description

Oral tobacco composition

The present invention relates to an oral tobacco composition containing a tobacco material and a gum base.

Conventionally, a chewable oral tobacco composition containing a tobacco material and a gum base has been known (for example, refer to Patent Document 1 and Patent Document 2).

In the oral tobacco composition described in Patent Document 1, the blending ratio of the tobacco raw material is 10% by weight or more and 40% by weight or less, so that the amount of nicotine dissolved during chewing is excessive, and the stimulation to the user when chewing is too strong. The problem that makes it difficult for the user to continue chewing.

Advanced technical literature

Patent Document 1: Japanese Patent Publication No. 05-039586

Patent Document 2: U.S. Patent No. 4,802,498

The first feature of the present invention is an oral tobacco composition containing a tobacco material and a gum base, wherein the blending ratio of the tobacco material is more than 0.5% by weight and less than 6.0% by weight, and the powder material constituting the tobacco material is formed. It is a sieved sieve having a particle size of 0.212 mm or more.

In the first feature, the granules constituting the tobacco raw material may be granules having a sieve size of less than 0.5 mm. In the first feature, the tobacco material may be composed of burley leaf tobacco having a 5% nicotine content.

Fig. 1 is a graph showing an example of the particle size distribution of the tobacco raw material contained in the oral tobacco composition of the embodiment.

Fig. 2 is a view showing the results of Experiment 1-1.

Figure 3 is a graph showing the results of Experiment 1-2.

Fig. 4 (a) and Fig. 4 (b) are diagrams showing the results of Experiment 2-1.

Fig. 5 is a view showing the results of Experiment 3.

(one embodiment)

Hereinafter, an oral tobacco composition according to an embodiment will be described with reference to Fig. 1 . Here, the oral tobacco composition of the present embodiment is a chewable oral tobacco composition (so-called tobacco gum) containing a tobacco raw material and a gum base.

In general, in the composition for oral tobacco, the amount of nicotine dissolved during chewing is appropriately adjusted so as not to impair the fragrance imparted to the user at the time of chewing (taste of tobacco), and to avoid excessive stimulation to the user during chewing. It is important.

That is, for the user, the nicotine contained in the tobacco material is a cause of stimulation in addition to the fragrance.

Therefore, in the composition for oral tobacco of the present embodiment, the average amount of nicotine elution per unit time from the start of chewing to a predetermined period (for example, 5 minutes) is 7 μg or more and 85 μg or less.

Further, in the composition for oral tobacco of the present embodiment, the average amount of nicotine elution per unit time from the start of chewing to a predetermined period (for example, 5 minutes) is preferably 14 μg or more and 70 μg or less, more preferably 30 μg or more and 55 μg or less.

Here, if the average amount of nicotine dissolved per unit time during the start of chewing is less than 7 μg from the start of chewing, the tobacco taste (flavor) imparted to the user at the time of chewing is too weak, so the user cannot distinguish between The satisfaction of being a composition for oral tobacco cannot be obtained by the difference in the glue blended with the tobacco material.

On the other hand, if the average nicotine elution amount per unit time in the start of chewing is greater than 85 μg from the start of chewing, the irritation given to the user at the time of chewing becomes strong, and the user cannot continue chewing the oral tobacco composition.

Therefore, the composition for oral tobacco of the present embodiment is different from the nicotine gel which is configured such that the average amount of nicotine elution per unit time is fixed, and the average amount of nicotine per unit time after the start of chewing is 5 minutes, which is low. It consists of the average amount of nicotine dissolved per unit time from the start of chewing to 5 minutes.

In addition, the predetermined period mentioned above assumes that the user smokes In the present specification, an example in which the predetermined period is defined as 5 minutes is described in the present specification. However, the present invention is not limited to this example, and an example in which the predetermined period is set to a time other than 5 minutes may be applied. .

Further, the blending ratio of the tobacco raw material contained in the oral tobacco composition of the present embodiment is configured to be more than 0.5% by weight and less than 6.0% by weight.

Further, the blending ratio of the tobacco raw material contained in the oral tobacco composition is preferably 1.0% by weight or more and 5.0% by weight or less, more preferably 2.0% by weight or more and 4.0% by weight or less.

Here, by setting the blending ratio of the tobacco raw material in the oral tobacco composition of the present embodiment to a value within the above range, the average amount of nicotine elution per unit time from the start of chewing to 5 minutes can be easily 7 μg or more and 85 μg or less. The value within the range.

Here, the inventors of the present invention found that the larger the particle diameter of the tobacco raw material contained in the composition for oral tobacco, the greater the effect of increasing the amount of nicotine dissolved in the initial stage of chewing.

Therefore, by making the particle diameter of the tobacco raw material in the oral tobacco composition of the present embodiment large, the blending ratio of the tobacco raw material contained in the oral tobacco composition is higher than that of the existing oral tobacco composition. When the blending ratio of the tobacco raw material is small, the nicotine elution amount in the initial stage of chewing can be made appropriate, and the fragrance imparted to the user at the time of chewing can be prevented from being damaged.

Specifically, the granules of the tobacco raw material constituting the oral tobacco composition of the present embodiment are granules having a mesh size of 0.212 mm or more. For example, from the granules that make up the tobacco material The granules having a particle diameter of less than 0.212 mm are removed by sieve to obtain a granule having a particle diameter of 0.212 mm or more.

Here, when the granules having a particle size of less than 0.212 mm which have been subjected to sieve classification are used as the tobacco raw material of the oral tobacco composition of the present embodiment, the amount of nicotine eluted at the initial stage of chewing is insufficient.

In other words, according to the above configuration, the nicotine elution amount at the initial stage of chewing can be appropriately adjusted by adjusting the particle size of the powder or granules constituting the tobacco raw material contained in the composition for oral tobacco.

Further, the granules constituting the tobacco raw material contained in the oral tobacco composition of the present embodiment are preferably granules having a particle size of less than 0.5 mm which are sieved and classified, and more preferably have a particle size which has been sieved and classified. Up to 0.35mm of powder and granules.

Here, the powder or granules having a particle diameter of less than 0.5 mm are obtained by removing the granules having a particle diameter of 0.5 mm or more from the granules constituting the tobacco raw material by sieve. Similarly, the powder or granules having a particle diameter of less than 0.35 mm are obtained by removing the powder or granules having a particle diameter of 0.35 mm or more from the granules constituting the tobacco material.

Here, when the granules having a particle size of 0.5 mm or more which have been sieved and classified are used as the tobacco raw material contained in the oral tobacco composition of the present embodiment, there is a feeling of foreign body sensation or damage to the user during chewing. The beauty of the products.

In addition, as the tobacco raw material contained in the oral tobacco composition of the present embodiment, for example, a tobacco raw material of a raw material species widely used in general tobacco products such as burley or yellow is used. Also note the following In the illustrated embodiment, the tobacco material is a tobacco material comprising burley leaf tobacco having a nicotine content of about 5% per dry weight of the tobacco material. In addition, "about 5%" means that there is a slight error, for example, a range of 4% or more and 6% or less.

Further, the oral tobacco composition of the present embodiment may contain various flavors or sweeteners for use in tobacco products or chewing gums.

Example

Experiments 1 to 3 were carried out using the chewing tester and artificial saliva shown below.

<Chewing Test Machine>

In Experiments 1 to 3, the chewing tester used an automatic mortar (manufactured by Nitto Co., Ltd.: ANM-150).

Here, with respect to the mortar and the pestle used in the chewing tester, a groove for simulating teeth (width 1 mm, depth 1 mm) is formed at regular intervals on the basis of the center position of the mortar and the pestle. .

Further, the chewing tester was placed in a constant temperature dryer (manufactured by Tokyo Chemical Industry Co., Ltd.: NDO-710W) to fix the temperature at the time of measurement. In addition, in order to stabilize the chewing action of the chewing tester, a stainless steel ball of Φ 11 mm was added to the mortar.

Further, in the above-mentioned chewing tester, when 20 ml of warm water and one of the commercially available rubber were added to the above-mentioned mortar, the chewing action was performed at a ratio of 60 to 80 times per minute.

<artificial saliva>

In addition, the artificial saliva used in the experiments 1 to 3 is as follows Way to make.

First, a mixed solution containing various reagents shown in Table 1 and 100 ml of ultrapure water was prepared.

Second, 6 ml of a citric acid (25 mM) solution was added to the above mixed solution.

Third, 100 ml of a potassium chloride (15 mM) solution was added to the above mixed solution.

Fourth, ultrapure water was added to make the above mixed solution 1L.

<Experiment 1-1 and 1-2>

According to Experiments 1-1 and 1-2, the suitability of the experiment using the above chewing tester and artificial saliva was examined. Here, the test samples of the oral tobacco compositions used in Experiments 1-1 and 1-2 were produced in the following manner.

First, about 25 g of a gum base (CL-NTM7 manufactured by Fuji Chemical Co., Ltd.) was placed in a disposable 100 ml disposable cup and capped, and then heated in an oven at 80 ° C for 5 minutes.

Second, the heated gum base was subjected to a kneading treatment for 2 minutes using a planetary mixer (AR-100 manufactured by Thinky Co., Ltd.).

Thirdly, a predetermined amount of the filament tobacco raw material was placed on the above-mentioned gum base, and then subjected to a kneading treatment for 7 minutes using a planetary mixer, thereby obtaining a test sample.

Further, when the kneading state was uneven, the mixture was gently stirred with a medicine spoon, and then kneaded by a planetary mixer for 3 minutes.

Further, in Experiments 1-1 and 1-2, when the test sample was chewed by the chewing tester, the amount of nicotine dissolved in the artificial saliva was measured in the following manner.

First, 25 ml of artificial saliva was transferred to a spiral tube (No. 6).

Second, the spiral tube (No. 6), the mortar and pestle, and the test sample (in the state of Nitoflonfilm) were placed in an oven (45 ° C) for 30 minutes.

Third, 5 ml of a mixed solution of 1000 ml of ethanol and 0.04 ml of 1,3-butanediol was placed in a spiral tube (No. 5).

Fourth, a mortar and pestle was installed in the chewing test machine, and 20 ml of artificial saliva was added.

Fifth, the chewing tester was started and the test sample was put into use.

Sixth, after a predetermined period of time, the chewing tester was closed, and 500 ml of the eluate obtained by the chewing tester was placed in a spiral tube (No. 5), and then covered with a sealing film and shielded with aluminum foil.

The seventh, after shaking for 30 minutes, put it into the sample bottle and supply it. Gas Chromatography Mass Spectrometer (GCMS).

Further, in Experiments 1-1 and 1-2, when the test sample was chewed with 1 g of the test sample, the amount of nicotine remaining in the test sample was measured in the following manner.

First, 20 ml of a mixed solution of 1000 ml of n-hexane and 500 mg of n-pentadecane was placed in a centrifugal sedimentation tube having a capacity of 50 ml.

Second, the test sample after chewing was placed in the above-mentioned centrifugal sedimentation tube, and the aluminum foil was shielded by light and shaken for 2 hours.

Third, after confirming that the test sample was dissolved, 15 ml of an 11% aqueous sodium hydroxide solution was added, followed by shaking for 1 hour.

Fourth, the centrifuge was centrifuged at 3,500 rpm for 5 minutes in a centrifuge.

Fifth, take the liquid to the gas chromatography mass spectrometer (GCMS).

Figure 2 shows the results of Experiment 1-1. Specifically, the amount of nicotine dissolved in artificial saliva and the amount of nicotine remaining in the test sample after 10 minutes and 20 minutes after the experiment 1-1 were measured.

As shown in Fig. 2, according to the results of Experiment 1-1, the total amount of nicotine dissolved in artificial saliva after 10 minutes and 20 minutes and the amount of nicotine remaining in the test sample were almost matched with the test. The nicotine content of the filaments of the sample was equal.

Figure 3 shows the results of Experiment 1-2. Specifically, in the measurement experiment 1-2, the amount of nicotine remaining in the test sample after the user performs free chewing for 10 minutes, and chewing by the chewing test machine for 10 minutes The amount of nicotine remaining in the sample after the test.

As shown in Fig. 3, according to the results of Experiment 1-1, it was found that the amount of nicotine remaining in the test sample after 10 minutes of free chewing by the user and the test sample remaining after chewing for 10 minutes by the chewing tester The amount of nicotine is almost equal.

Therefore, from the results of Experiments 1-1 and 1-2, it was found that various experiments were carried out using the above chewing tester and artificial saliva.

<Experiment 2>

Experiments 2-1 and 2-2 were conducted to investigate the relationship between the blending ratio of tobacco raw materials in the composition for oral tobacco and the flavor and irritation imparted to the user.

In Experiment 2-1, the relationship between the amount of nicotine eluted at the time of chewing and the blending ratio of the tobacco raw material in the composition for oral tobacco was measured.

For the test samples, 1.5% by weight (Example 1), 3.0% by weight (Example 2), and 6.0% by weight (Example 3) were blended in 1 g of a gum base (CL-NTM7 manufactured by Fuji Chemical Co., Ltd.). Tobacco powder granules were prepared by the method of Experiment 1. In addition, the tobacco material uses a variety containing about 5% nicotine per dry weight.

Figure 4 (a) and (b) show the results of Experiment 2-1. Fig. 4(a) shows the change in the average amount of nicotine dissolved per unit time during chewing with time, and Fig. 4(b) shows the average amount of nicotine dissolved per unit time from the start of chewing to 5 minutes.

In addition, the average amount of nicotine dissolved per unit time was calculated by the following formula.

(Nicotine dissolution per unit time) = (Nicotine in the scheduled chewing time) Total dissolved amount) / (predetermined chewing time)

Further, in Experiment 2-2, in order to investigate the relationship between the blending ratio of the tobacco raw material in the oral tobacco composition and the flavor and irritation imparted to the user, a sensory evaluation test was performed.

Specifically, in Experiment 2-2, the upper limit value of the blending rate of the tobacco material that can be chewed by the user is investigated (the upper limit value of the blending ratio of the tobacco raw material which is not excessively provoked by the user), And the lower limit of the blending rate of the tobacco raw material in which the user can feel the taste (flavor) of the tobacco.

The functional evaluation method for investigating the upper limit of the blending rate of the tobacco material which can be chewed by the user is as follows.

First, each user was allowed to chew test samples 1 and 2. Here, the tobacco raw material blending ratio of the test sample 1 was 3.0% by weight, and the tobacco raw material blending ratio of the test sample 2 was 6.0% by weight.

Both the test sample 1 and the test sample 2 were blended with a predetermined amount of tobacco powder granules in 1 g of a gum base (CL-NTM7 manufactured by Fuji Chemical Co., Ltd.), and were produced in the same manner as in Experiment 1. In addition, the tobacco material uses a variety containing about 5% nicotine per dry weight.

Secondly, in each user, when it is difficult to continue chewing by giving too much stimulation to the user, the evaluation is interrupted.

Third, the ratio of users who can continue chewing from the start of chewing for more than 5 minutes is determined. The total number of users is 10.

The results of this experiment are shown in Table 2.

According to the results of the experiment, it is known that the upper limit of the blending rate of the tobacco material which can be chewed by the user is less than 6.0% by weight (the nicotine content per gel is about 3.0 mg). That is, the tobacco raw material contains a nicotine content of about 5%.

On the other hand, the sensory evaluation method for investigating the lower limit of the blending ratio of the tobacco raw material in which the user can feel the taste of tobacco is as follows.

First, each user was allowed to chew the test sample containing no tobacco raw material, and the test samples 3 and 4 for 10 minutes each. Here, the tobacco raw material blending ratio of the test sample 3 was 0.5% by weight, and the tobacco raw material blending ratio of the test sample 4 was 1.5% by weight.

Both the test sample 3 and the test sample 4 were prepared by blending a predetermined amount of tobacco granules with 1 g of a gum base (CL-NTM7 manufactured by Fuji Chemical Co., Ltd.) and carrying out the method of Experiment 1. In addition, the tobacco material uses a variety containing about 5% nicotine per dry weight.

Secondly, each user was asked whether or not the taste (flavor) difference was felt between the test sample containing no tobacco raw material and the test sample 3 or 4.

Third, the measurement was evaluated as the difference in taste (flavor) between the test sample containing no tobacco raw material and the test sample 3 or 4. The ratio of users. The total number of users is 10.

The results of this experiment are shown in Table 3.

According to the results of the experiment, it is understood that the lower limit of the blending ratio of the tobacco material which the user can feel the taste of tobacco is 0.5% by weight (the nicotine content per gel is about 0.25 mg). That is, the tobacco raw material contains a nicotine content of about 5%.

Therefore, according to the results of Experiment 2, when the tobacco raw material blending ratio of the oral tobacco composition is more than 0.5% by weight and less than 6.0% by weight, the user can obtain a moderate tobacco taste without feeling excessively strong.

<Experiment 3>

Experiment 3 is an experiment to investigate the relationship between the particle size of the tobacco material in the composition of the oral tobacco and the average amount of nicotine dissolved per unit time.

In the experiment 3, the test sample A used an oral tobacco composition containing a tobacco raw material composed of a sieved particle size of less than 0.212 mm, and the test sample B used a sieve-containing particle. The oral tobacco composition of the tobacco raw material having a diameter of 0.212 mm or more and 0.36 or less is used, and the test sample C is composed of a powder or granule containing a sieve-graded particle diameter of 0.50 mm or more and 0.71 or less. The oral tobacco composition of the tobacco raw material, the test sample D is an oral tobacco composition containing a tobacco raw material composed of a sieved particle size of 1.10 mm or more and 1.18 or less, and the test sample E is used. An oral tobacco composition comprising a tobacco material comprising a sieved particle size of 1.4 mm or more and 2.0 or less.

Each of the test samples was prepared by blending 30 mg of tobacco granules with 1 g of a gum base (CL-NTM7 manufactured by Fuji Chemical Co., Ltd.) and the method of Experiment 1. Here, the particle size distribution of the tobacco raw materials for each test sample is a stainless steel sieve based on JIS Z 8801, and the pulverized tobacco powder granules are used according to a screening test method based on JIS Z 8815. Screening is graded for adjustment. Specifically, a sieve having a plurality of types of meshes (0.212 mm, 0.36 mm, 050 mm, 0.71 mm, 1.10 mm, 1.4 mm, 2.0 mm) was used, and shaking was continued for 20 minutes in a dry and mechanical oscillation method. Classification of pulverized tobacco granules. In addition, the particle size obtained by sieving classification may contain an error (about 5% or less). For example, even if a sieve having a mesh size of 0.212 mm is used for sieving and grading a tobacco material having a particle diameter of 0.212 mm or more, the tobacco raw material after sieving and grading is somewhat inaccurate (about 5% or less), and may have a particle diameter of Tobacco raw materials of 0.212 mm or less are also acceptable.

Specifically, the pulverized tobacco raw material is passed through a 0.212 mm sieve and only the tobacco raw material A is obtained by passing through the sieve. Similarly, the comminuted tobacco material was passed through a 0.36 mm sieve, and then passed through a 0.212 mm sieve and only the tobacco material B was obtained without passing through the sieve. Similarly, the pulverized tobacco material was passed through a 0.71 mm sieve, and then passed through a 0.50 mm sieve and only the tobacco material C was obtained without passing through the sieve. same The pulverized tobacco material was passed through a 1.18 mm sieve, and then passed through a 1.10 mm sieve and only the tobacco material D was obtained without passing through the sieve. Similarly, the comminuted tobacco material was passed through a 2.0 mm sieve, and then passed through a 1.4 mm sieve and only the tobacco material E was obtained without passing through the sieve.

The mode diameters of the tobacco raw materials A to E obtained as described above are respectively within the range of 0.212 mm, 0.212 mm to 0.36 mm, 0.50 mm to 0.71 mm, and 1.10 to 1.18 mm, and 1.4 mm to Within the range of 1.18mm.

As a result of the experiment 3, as shown in Fig. 5, in the test samples B to E having a sieve-graded particle diameter of 0.212 mm or more, the average amount of nicotine elution per unit time in the initial stage of chewing was particularly increased.

It can also be seen that in the test samples B to E, as shown in Fig. 5, the average difference in the amount of nicotine per unit time after the start of chewing for 5 minutes and the average amount of nicotine per unit time after 10 minutes from the start of chewing is the largest. The difference in the average amount of nicotine dissolved per unit time is then reduced.

On the other hand, it can be seen that the difference between the average amount of nicotine dissolved per unit time after the start of chewing and the average amount of nicotine per unit time after 10 minutes of chewing is 5 minutes after the sieve classification, the average amount of nicotine dissolution per unit time after the start of chewing is 5 minutes after the start of chewing. Compared with other test samples B to E, it is significantly smaller.

Therefore, according to the result of Experiment 3, when the sieved granules having a particle diameter of 0.212 mm or more are used as the granules of the tobacco raw material constituting the composition for oral tobacco, even if the composition for oral tobacco is used The blending rate of the tobacco raw material is suppressed to a low level, and the amount of nicotine eluted in the early stage of chewing can also be increased, and the user can be given a moderate tobacco taste.

The present invention has been described in detail above using the embodiments described above, but it is obvious to those skilled in the art that the present invention is not limited to the embodiments described in the present specification. Modifications and variations can be made without departing from the spirit and scope of the inventions. Therefore, the description of the present specification is intended to be illustrative, and not to limit the invention.

In addition, the entire contents of Japanese Patent Application No. 2012-133285 (when June 12, 2012) are referred to and used in the present specification.

[Industrial availability]

According to the present invention, it is possible to provide an oral tobacco composition which can avoid excessive stimulation to the user during chewing and which can impart a sufficient fragrance to the user in the initial stage of chewing.

Claims (3)

An oral tobacco composition comprising a tobacco raw material and a gum base, wherein the tobacco raw material blending ratio of the oral tobacco composition is more than 0.5% by weight and less than 6.0% by weight, and the powder material system constituting the tobacco raw material is formed. A sieve having a sieve classification having a particle diameter of 0.212 mm or more. The oral tobacco composition according to claim 1, wherein the powder system constituting the tobacco material is subjected to sieve classification and has a particle size of less than 0.5 mm. The oral tobacco composition according to claim 1 or 2, wherein the tobacco raw material is composed of burley leaf tobacco having a 5% nicotine content.