201036541 六、發明說明： 【發明所屬之技術領域】 本發明係關於一種農藥藥劑，其含有可為保護農作物 之藥劑而免於由蟲害以及病害之有害於農作物，更詳言 之，係關於控制有效成份的溶出性，不僅在插秧前，且在 . 從移栽後至出穗期以後之可防蟲害之農藥製劑以及使用該 等藥劑之水稻病蟲害的防治方法者。 【先前技術】 〇 農藥係使用於以農作物為對象使免於雜草、蟲害、病 害等為保護目的，製劑的種類以及該處理時期係因應於有 效成份之特徵及使用目的而有各式各樣者。 近年來，由於農作者的減少或高齡化的問題，希望在 喷灑農藥上可省力化。而該情況的根源係由於在病蟲害防 治的領域上，因應代表育苗箱處理之插秧前處理的藥劑已 關發不少，其結果，需要花費眾多勞力之稻田散佈的情形 已比以前銳減不少。然而，最近以東曰本為中心，因椿象 ° 而使出穗期後之水稻受害增多，另一方面，因市售製劑無 法防治於插秧前處理之該害蟲，所以儘管已在插秧前進行 藥劑處理之水田也不得不在生長後期之稻田喷灑適當的藥 劑以預防椿象蟲害係為實況。 【發明内容】 (發明所欲解決之技術問題） 本發明之課題係為提供一種可抑制對水稻之病蟲害有 防治效果之農藥活性成份之溶出性控制，可防治連既有的 4 314623D01 201036541 市售製劑都棘手之出穗期以後之蟲害者，在插秧前的一次 藥劑處理便可防治在水稻栽種期間之主要病蟲害的藥劑。 (解決問題之技術手段） 本發明人等針對有關多數之溶出控制型農藥製劑，對 該溶出性以及防治效果專心致志研究後之結果，發現將含 • 有效成份之心材以難溶水性之膜包覆成型之農藥製劑，係 可解決上述之課題者，遂達成本發明。 亦即，本發明係關於（1)含農藥活性成份之心材以不溶 ® 水性或難溶水性之膜包覆所得之持續釋放化包覆製劑，以 及使用該製劑於水稻育苗培土混合處理，播種時之處理或 從幼苗期至插秧期間之育苗箱處理中，以防治從水田初期 至出穗後期間所發生的水稻病蟲害之方法、（2)對防治從水 田初期至中期的蟲害，加上出穗期以後的椿象類害蟲的有 效之如（1)所記載之持續釋放化包覆製劑以及使用該劑之 病蟲害防治方法者。 Q 而且，本發明係有關持續釋放化包覆製劑以及使用該 製劑之病蟲害防治方法，其特徵係包含：使用橡膠以及蠟 為包覆膜之成份，在包覆膜内調配以在25°C之水溶解度為 lOppm以上之化合物作為農藥活性成份，更在包覆膜内調 配有式1 : [式1]201036541 VI. Description of the Invention: [Technical Field] The present invention relates to a pesticide agent which is useful for protecting crops from pests and diseases and is harmful to crops, and more particularly to control The dissolution property of the ingredients is not only before the transplanting, but also the pesticidal pesticide preparations after the transplanting to the heading period, and the methods for controlling the rice pests and diseases using the medicines. [Prior Art] 〇Pesticide is used for the protection of weeds, insect pests, diseases, etc. for crops. The type of preparation and the treatment period are various depending on the characteristics of the active ingredients and the purpose of use. By. In recent years, due to the reduction of agricultural authors or the problem of aging, it is hoped that labor can be saved by spraying pesticides. The root cause of this situation is that in the field of pest control, the pre-implantation treatments that have been treated on behalf of the nursery box have been shut down a lot. As a result, the situation of rice fields that need to spend a lot of labor has been reduced a lot. . However, recently, the sputum has been used as the center, and the rice after the earing stage has been damaged due to the °[°]. On the other hand, since the commercially available preparation cannot control the pest before the transplanting, the medicinal agent has been administered before the transplanting. The treated paddy fields also had to spray appropriate pesticides in the late growth paddy fields to prevent the mites pests from being live. SUMMARY OF THE INVENTION (Technical Problem to be Solved by the Invention) The object of the present invention is to provide a dissolution control of an active ingredient of a pesticide which can inhibit the control of pests and diseases of rice, and can be controlled and controlled by the existing 4 314623D01 201036541. In the case of insects that are difficult to produce after the earing stage, a chemical treatment before the transplanting can control the main pests and diseases during rice planting. (Technical means for solving the problem) The inventors of the present invention have found that the heart material containing the active ingredient is coated with a film which is hardly soluble in water, and the result of the research on the dissolution and the control effect of the majority of the dissolution-controlled pesticide preparations. The molded pesticide preparation can solve the above problems and achieve the present invention. That is, the present invention relates to (1) a sustained-release coating preparation obtained by coating a heart material containing a pesticidal active ingredient with an insoluble/aqueous or poorly water-soluble film, and using the preparation in a rice seedling soil mixing treatment, when planting For the treatment of rice seedlings from the seedling stage to the transplanting period, to control the rice pests and diseases that occur from the early stage of the paddy field to the period after the earing, and (2) to control the pests from the early to the middle of the paddy field, plus the ear The herbaceous pests after the period are effective as the sustained release coating preparation described in (1) and the pest control method using the same. Further, the present invention relates to a sustained release coating preparation and a pest control method using the same, characterized in that it comprises: using a rubber and a wax as a coating film, and blending in a coating film at 25 ° C A compound having a water solubility of 10 ppm or more is used as an active ingredient of a pesticide, and is further formulated in a coating film: [Formula 1]
/C=X—Y R1-CH2—N 5 314623D01 201036541 [式中，X表示CH或N; Y表示硝基或氰基；Rl表示可以南 素取代之3-吡啶基、可以鹵素取代之5_噻唑基、或可以甲 基取代之3-四氫咬嚼基；R2表示氫原子或Cl_4烷基；R3表 示NR R、SR、0R或R所表之基（在此之R4係表示氯原子 或C〗-4烷基、R、R、R7以及R8係表示Ci 4烷基）；或者是 R2與R5、R6、R7或R8併為伸乙撐基、三亞f基、CH2〇CH2所 表之基、或CH2N(R )CH2所表之基（在此之^9係表示Ci 4烷基）] 所示（新於驗劑）之化合物。/C=X—Y R1-CH2—N 5 314623D01 201036541 [wherein, X represents CH or N; Y represents a nitro group or a cyano group; and R1 represents a 3-pyridyl group which may be substituted by a south, and may be substituted by a halogen 5_ a thiazolyl group or a 3-tetrahydrocinch group which may be substituted with a methyl group; R 2 represents a hydrogen atom or a Cl 4 alkyl group; and R 3 represents a group represented by NR R, SR, OR or R (wherein R 4 represents a chlorine atom or C -4-alkyl, R, R, R 7 and R 8 are represented by Ci 4 alkyl); or R 2 and R 5 , R 6 , R 7 or R 8 are in the form of an extended ethylene group, a triphenyl group, and a CH 2 〇 CH 2 group. A compound represented by a group or a group represented by CH2N(R)CH2 (wherein the group 9 represents a Ci 4 alkyl group)] (newly tested).
[式中’ Z1以及Z2表示相同或相異之氫原子、鈉、鉀、氰基、 可以1至2個Ch烷基取代之胺基甲醯基、可以Ci_3烷基取 代之苯磺醯基、磺基（S〇3H)、S〇3M所表之基（M表示納或 ❹鉀）、亞磺基（S〇2H)、或S〇2M表示之基（M表與上述者同義） 所示之基；或者將Z1與Z2 一起鍵結或以s表示；或者zl 以0表示，此時之Z2係表示和與z〗鍵結之硫原子鍵結]所 示（沙蠶毒素劑）之化合物或其鹽作為農藥活性成份者。 【實施方式】 本發明係，一種持續釋放化包覆製劑，其特徵係將含 農藥活性成份之心材包覆在以對水之親和性低之材料為主 成份之皮膜内，以及以該製劑在插秧前處理以防治從水田 初期至出穗後所發生病蟲害之方法。 314623D01 6 201036541 初期至出穗後所發生病蟲害之方法。 本發明之製劑之基本構造Ml圖所示。本發明之製 d係以含有效成份為心材，以對水親和性低之材料為 、 份之皮膜包覆者，調整皮膜的組成以及量可實現以防二成 蟲害為目的之適當的溶出性者。 病 Ο ❹ 在本發明中所使用的皮膜並無特別限制，只要是— 可使用於醫藥、農藥、食品、化粧品等領域上即可疋：: 效果、、成本、製造時之操作性等方面看來，錢用橡= 鼠者為理想。橡膠可為天然橡膠亦可為合成橡膠，以人、 橡膠為佳，又以合成乳膠為更佳，更以後述之丁二稀:成 體之合成乳膠為最佳。而且，蠛以壤乳為更佳。在使用= 成乳谬以及壤乳時，以使用固體成份重量比為對合成乳二 8之至少為1以上之比例者為佳。 成錄 本發月中所使用之合成乳膠係可使用任何的乳取 代苯表乙之:Γ如:苯乙稀-丁二綱、甲基甲基丙雄酸酸 本乙烯丁一烯乳膠、乙丙乳膠、丁二烯乳膠、 乳膠、料1膠等，此等可單獨或混合2種以上使用、。― “本發明中所使用之壤乳係來自於動植物或石油樹q =的乳化物，可例舉如:石·、微晶犧乳、聚埽_ 適用於調配在内膜内之本發明之農祕益 別限制，_译如：可^(⑽㈣_、吼蟲胺 (mtenpyram)、賽速安（thi繼&。細）、狄諾吱嗟 (dln〇iefUran)、益達胺（imidacloprid)、提錢 314623D01 7 201036541 (thiacloprid)、亞滅培（acetamiprid)、培丹（cartap)鹽 酸鹽、免速達（bensultap)、硫賜安（thiocyclam)、芬普尼 (fipronil)、乙塞普^(ethiprole)、亞西普羅 (acetoprole)、賜諾殺（spinosad)、派滅淨 . (pymetrozine)、免扶克（benfuracarb)、丁基加保扶 • (carbosulfan)、σ夫線威（furathiocarb)、大利松 (diazinon)、乙基硫滅松（ethylthiometon)、加護松 (propaphos)、PHC (partially halogenated CFC)等殺蟲 Ο 劑、歐立沙特賓（orysastrobin)、亞托敏（azoxystrobin)、 苯氧菌胺（met⑽inostrobin)、α塞大尼（thiadinil)、加普 胺（carpropamid)、紋枯病殺菌劑二氯西美（diclocymet) 芬諾沙尼（fenoxanil)、亞西苯左拉· S ·曱酯 (acibenzolar-S-methyl)、撲殺熱（probenazole)、三賽唑 (tricyclazole)、百快隆（pyroquilon)、亞賜圃 (isoprothiolane)、福拉比（furametpyr)、賽氟滅 ❹ （thifluzamide)、石夕氟唾（simeconazole)等之殺菌劑。其 中亦以在25°C下之溶解度為l〇ppm以上之化合物為佳。尤 以可尼可、°比轰胺、塞速安、狄諾吱鳴、益達胺、硫克羅 立等之新菸鹼劑為更佳，該等可以單獨或2種以上同時使 用。尤其，本發明之持續釋放化包覆製劑因應此防治目的 亦可調配與膜内相同或相異之農藥活性成份於膜外，亦可 調配無農藥活性之各種助劑。可調配於上述皮膜内中之化 合物係可調配於膜外使用，可增強對水田初期所發生之病 蟲害的防治效果。並可調配於膜内以及膜外之成份亦可使 314623D01 8 201036541 用具汰草龍（dymron)等減輕藥害作用之化合物，在育苗期 間之病害防治亦可使用調配於膜外之春雷黴素 (kasugamycin)等。 本發明之持繽釋放化包覆製劑使用於插秩前，可防治 • 由水稻水象鼻蟲XLissorhoptrus oryzophilus)、稻象鼻轰 (Echinocnemus squameus)、稻氨泥^XOulema oryzae) ^ 之鞘翅目（Coleoptera)害蟲；稻小潛葉蠅 貧riseoia)、稻潛葉绳（如ro/z/yza oryzae)、稻桿繩 g% XChlorops oryzae)、稻心織Cffydreiljia sasakii)、等之 雙翅目（Diptera)害蟲；偽黑尾葉蟬 ci/iiiceps)、電光葉蟬(i?eci"a dorsa/is)、白背飛蝨 (Sogatella furcifera)、斑散鉍 QLaodelphax striatellus)、褐飛蝨（Nilaparvata lugens)、稻 M、棒象 (Scoti/JopAara iuricfa)等之半翅目（Hemiptera)害蟲；瘤 野填CCnaphalocrocis medinalis)、二化塔蟲XChilo Q SL/ppressaiis)、三化螟（Γ_πφ〇γτζ3 i/7certL?ias)、稻弄蝶 (Parnara guttata)、稻螟蛉（Naranga contaminata)、稻 大填（Sesamia inferens)、粟夜織（Pseudaletia separata)、鱗翅夜蛾（Piusia /esiucae)等之鱗翅目 (Lepidoptera)害蟲；稻薊馬（5aiio仇rips 等之 缨翅目（Thysanoptera)害蟲；稻埴（(9xya j^zoe/jsis)、曰 本稻蝗（toya_/apo/2ica)等之直翅目（Orthoptera)害蟲；福 壽螺（尸o/z/acea ca/]aiicuiaia)等之從水田初期至中其所發 生之蟲害以及稻熱病（由葉稻熱菌#a^72aport/7e f isea引 9 314623D01 201036541 起）、水稻紋枯病（由瓜亡草菌77?a/3a iepAorus ct/ci//Herj· s 引起）、水稻胡麻葉斑病（由水稻旋孢菌Cbc/2iioZ?o2i7S /»iyabea/2L/s·引起）、水稻白葉枯病（由水稻潰瘍病原菌 Xanthomonas campestris pv. oryzae 弓| 起)等之水稻病 害，尤其是以持續釋放製劑可防治在出穗其後所產生問題 之斑點米椿象（r i ce ear bugs)，因而可防治在水稻栽種期 間的主要病蟲害。以斑點米捲象為目標者可例舉如：黑盲 捲（Adelphocoris sutural is)、斑黑賓捲（Adelphocoris 〇 triannulatus)、綠 t 棒（Apolygus lucorm)、斑 t 棒（Lygus saunders i) ^-(Lygus rugul ipennis) - # {Stenotus rubrovittatus)、右賓棒（Stenodema calcaratum)、江管噶祷CStenodema rubrinerve)、長右育 椿（Ste/3〇iie/na sibiricmo)、赤鬚細綠盲椿 caeJesiriahuffl)等之盲椿象科（Miridae);豆突眼長椿 (C/iaiiii叩s /aUax)等之突眼長椿象科（malcidae);姬平 長椿象（Cy肌/s aurescence)、紋白長椿象（Panaoriis[wherein Z1 and Z2 represent the same or different hydrogen atom, sodium, potassium, cyano group, aminomethylmercapto group which may be substituted with 1 to 2 Ch alkyl groups, phenylsulfonyl group which may be substituted with Ci_3 alkyl group, a group represented by a sulfo group (S〇3H) or S〇3M (M represents sodium or potassium), a sulfinyl group (S〇2H), or a group represented by S〇2M (the M table is synonymous with the above) a group; or Z1 and Z2 are bonded together or represented by s; or zl is represented by 0, in which case Z2 is a compound represented by a sulfur atom bonded to z] (the silkworm toxin agent) Or its salt as a pesticide active ingredient. [Embodiment] The present invention relates to a sustained release coating preparation characterized in that a heart material containing a pesticidal active ingredient is coated in a film mainly composed of a material having low affinity for water, and the preparation is Pre-insertion treatment to control the occurrence of pests and diseases from the early stage of paddy field to after emergence. 314623D01 6 201036541 The method of pests and diseases that occur from the initial stage to the earing. The basic structure M1 of the preparation of the present invention is shown. The d-form of the present invention is such that the active ingredient is used as the core material, and the material having a low water affinity is coated with the film, and the composition and amount of the film are adjusted to achieve appropriate dissolution for the purpose of preventing the second insect. By. Diseases ❹ The film used in the present invention is not particularly limited as long as it can be used in medicine, agrochemicals, foods, cosmetics, and the like: effects, cost, and manufacturability at the time of manufacture. Come, money is ideal with oak = rat. The rubber may be a natural rubber or a synthetic rubber, preferably a person or a rubber, and a synthetic latex is preferable, and a synthetic latex which is described later is preferably an adult synthetic latex. Moreover, it is better to use lochia. In the case of using = milk mash and loam, it is preferred to use a solid component weight ratio of at least 1 or more of the synthetic milk. The synthetic latex used in the month of the book can be used to replace the benzene table B with any milk: for example: styrene-butadiene, methylmethylpropyl maleic acid, vinyl butadiene latex, ethylene propylene latex And butadiene latex, latex, material 1, and the like, and these may be used alone or in combination of two or more. ― "The lobe milk used in the present invention is derived from an animal or plant or oil tree q = an emulsion, and may, for example, be a stone, a microcrystal, or a sputum, which is suitable for use in the inner membrane of the present invention. Restrictions on the benefits of peasant secrets, _ translation such as: can ^ ((10) (four) _, mtenpyram (mtenpyram), Sai Su An (thi followed by & fine), Dino〇 (dln〇iefUran), idedaamine (imidacloprid) , money 314623D01 7 201036541 (thiacloprid), acetamiprid, cartap hydrochloride, bensultap, thiocyclam, fipronil, ethep ^ (ethiprole), acetoprole, spinosad, pymetrozine, benfuracarb, carbosulfan, furathiocarb , diazinon, ethylthiometon, propaphos, particly halogenated CFC, insecticides, oresastrobin, azoxystrobin, benzene Oxystrobin (met(10)inostrobin), alpha thiadinil, carpropamid, striate Bactericidal fungicide diclocymet fenoxanil, acibenzolar-S-methyl, probenazole, tricyclazole, A fungicide such as pyroquilon, isoprothiolane, furametpyr, thifluzamide, simeconazole, etc., also at 25 ° C A compound having a solubility of 1 〇 ppm or more is preferred, and a neonicotinoid such as konico, phloem, acesulfan, dioxin, edetamine or thioglycol is preferred. And the like may be used alone or in combination of two or more. In particular, the sustained release coating preparation of the present invention may also be formulated with the same or different pesticide active ingredients in the film for the purpose of prevention and control, and may also be formulated without pesticide activity. Various additives. The compound which can be blended in the above film can be adjusted to be used outside the film to enhance the control effect on the pests and diseases in the early stage of the paddy field. The components which can be adjusted in the film and outside the film can also make 314623D01 8 201036541 dymron, etc. For compounds that are lightly toxic, the disease control during the seedling period can also be carried out by adding kasugamycin to the outside of the membrane. The present invention can be used for the prevention and treatment of the genus Coleoptera (Xinusorhoptrus oryzophilus), Echinocnemus squameus, and XOulema oryzae. Coleoptera) pests; rice leaf miner leanoia), rice leaf rope (such as ro/z/yza oryzae), rice rope rope g% XChlorops oryzae), rice heart weave Cffydreiljia sasakii), etc. Diptera ) pests; pseudo-black-tailed pheasant ci/iiiceps), electro-optic leaf mites (i?eci"a dorsa/is), white-backed locust (Sogatella furcifera), variegated genus QLaodelphax striatellus, brown planthopper (Nilaparvata lugens), rice M, rodent (Scoti/JopAara iuricfa) and other Hemiptera pests; CCnaphalocrocis medinalis, XChilo Q SL/ppressaiis, and mites (Γ_πφ〇γτζ3 i/7certL?ias) ), Lepidoptera pests such as Parnara guttata, Naranga contaminata, Sesamia inferens, Pseudaletia separata, Piusia / esiucae; Rice 蓟 horse (5aiio hatred rips Thysanoptera pests; Orthoptera pests such as rice blast ((9xya j^zoe/jsis), 蝗本稻蝗(toya_/apo/2ica); snails (corporate o/z/acea) Ca/]aiicuiaia), etc. from the early stage of the paddy field to the pests and rice fever (from the leaf rice heat bacteria #a^72aport/7e f isea cited 9 314623D01 201036541), rice sheath blight (from the dead grass Bacteria 77?a/3a iepAorus ct/ci//Herj·s caused), rice flax leaf spot (caused by C. cerevisiae Cbc/2iioZ?o2i7S /»iyabea/2L/s·), rice bacterial blight ( Rice diseases such as the rice canker pathogen Xanthomonas campestris pv. oryzae bow | especially the sustained release preparation can control the ri ce ear bugs caused by the problem after the emergence of the ear, and thus can be controlled in rice The main pests and diseases during planting. The target of the spotted rice roll can be exemplified by: Adelphocoris sutural is, Adelphocoris 〇triannulatus, Apolygus lucorm, Lygus saunders i ^- (Lygus rugul ipennis) - # {Stenotus rubrovittatus), Stenodema calcaratum, CStenodema rubrinerve, Ste/3〇iie/na sibiricmo, Chiss fine green 椿 caeJesiriahuffl ), such as Miridae; maldidae, such as C/iaiiii叩s /aUax; Cyping/s aurescence, long white Panaoriis
U albomculatus)、a 冬長格 $XPanaorus japonicus)、愛 白緣 ~k赛象（Panaorus csikii)、茶 l秦 KNeolethaeus da]iasi)、姬長椿象（iVysius p]ebeii/s)、南細長椿象 (Paromius piratoides)、黑足細長祷象（Paromius 棒象（Pachybrachius luridus)、銹長捲象（Pamerarma rustica)、鬚長椿象（PacAj^ro/itfta anteimaia)、湯長椿 象（Eucosmetus pallicornis)、微長棒象（Lygaeus 10 314623D01 201036541 egues tris)、琥珀長椿象（Togo Zze/Bipiertys)等之長椿象科 (Lygaeidae);蓋紋椿象（PyrjrAocoris siMrict/s)等之星 椿科（Pyrrhocoridae);小豆緣椿象（丑o/Hoeocert/s /nar^'iiij’yeniris)、長肩棘緣椿象（C7eti/s 、針 緣椿象（deti/s rt/siicus)、細針緣椿象（C/eii/s pimctiger)、一點同緣棒象（Homoeocerus unipunctatus) 等之緣椿象科（Coreidae);姬雲蛛緣椿象（尸arapiesii/s Li/n’coior)、中國禾葉椿象（Zepiocorisa cMfleiisis)、彎 〇 體雲蛛緣椿象（Leptocorisa oratorius)、豆椿象 cJaFaius)等之蛛緣椿象科（Alydidae);紅姬 緣椿象（Aeschynteles)、斑鬚椿象（StictopJeurt/s pw3ciat〇i2er7〇si/s)等之姬緣椿象科（Rhopalidae);褐盾椿 象（五Lurgaster iestiid!-£2aria)等之盾椿象科 (Scute 11 erida6);蝦黑椿象（Gonopsi’s af/inis)、鶴椿象 (Ze!ia Aeheri)、稻刺椿（Car^ia /iu/neriger)、稻紫椿 〇 (Carpocoris purpureipermis)、斑肖择象（Dolycoris /?accari/ffl)、鼻高椿象（/)冲⑽sicyia retj，ci/Jaia)、白點刺 捲象（Eysarcoris annamita)、二 K 椿象（Eysarcoris 即亡tiger)、大刺白星椿象（Eysarcoris _/etn·si)、刺白星 椿象aei^eus)、白星椿象（£ySarco_ris ventralis)、茶翅椿象（Halyoinorphr picus)、稻捲象 (La^yfloto/nus e/a^ah/s)、端白椿象（ffieudia WoJacea)、 花角椿象Oezara ai3ieMata)、南方綠椿象（Wezara W Wdda)、蝦綠椿象（Pa Jo/Hena osa)、一 字椿象 11 314623D01 201036541 (尸iezMor阳、橘茶翅綠椿象（巧如仏㈣ stali)、江疼 $XPygomenida bangalensis) ^ (Scoti/iopAara iwricia)等，可抑制該椿象类員 (Pentatomidae)之吸液所產生的斑點米。 又’在插秧前之藥劑處理亦可防治育苗期間所發生的 稻熱病等。 在插秧前之處理，其具體例可舉如：育苗培土混合處 理、播種期處理以及從幼苗期至插秧期為止之間的育苗箱 〇.處理專。該專之各處理法所處理之持續釋放化包覆製劑的 量並無特別限定’但以一般之稻育苗箱（約30cmx60cm)約 30至150g者為佳。本發明之持續釋放化包覆製劑不論育 苗培土之種類、稻品種以及該稻之遺傳基因是否重組皆可 使用，為防治稻傳染性病害以及從育苗培土所感染的病 害，可組合種稻處理或育苗期處理，以及其它製劑之稻田 處理或生物的防治、物理的防治等之其他方法的防治。並 Q且，在栽種水稻中，一般以除草劑來進行雜草防治或施肥 等組合，通常的水稻栽種時使用本發明物並無任何問題。 在製造本發明之持續釋放化包覆製劑時，除了橡膠、 蠟以及農藥活性成份以外，可添加使用一般農藥製劑所使 用的各種助劑（例如：載體、界面活性劑、黏合劑、流動助 劑、安定劑等）。載體可例舉如··植物性粉末（例如大豆粉、 木粉等）、鑛物性粉末（例如：高嶺土、皂土、酸性白土等 之黏土類、滑石粉、葉蠟石粉等之滑石類、矽藻土、雲母 粉等之二氧化矽類尊）、硫酸銨、後酸氫鈉等之水溶性載 314623D01 12 201036541 體、碳酸鈣、活性碳等。上述載體可單獨或同時2種以上 使用。界面活性劑可例舉如：聚氧乙撐聚氧丙撐嵌段聚合 物、木質磺酸鹽、炫基苯磺酸鹽、烧基萘續酸鹽等，黏合 劑可例舉如：α -澱粉、聚乙烯醇、羧甲基纖維素等，流動 助_劑可例舉如：白碳等。 本發明之持續釋放化包覆製劑係以橡膠及蠟以一般之 方法包覆含農藥活性成份之心材而製造的，尤其是製造預 先含活性成份之粒狀組成物，以該組成物為核係適用於以 f) 橡膠及蠟之混合物包覆之方法。 關於製劑形狀可得各式各樣的形態。可例舉如：球狀、 圓筒狀、顆粒型、長方體型、圓盤型、繩狀之型等各式各 樣之形態。在構造上，只要是具有以橡膠及蠟包覆著含農 藥活性成份之心材者即可。 上述粒狀組成物可以一般方法製造。可例舉如：混合 各種助劑與農藥活性成份，加入適量的水，在混合、擾合 ❹之後，經篩目擠壓之方法（擠壓造粒法）；旋轉粉體同時喷 灑霧狀黏合劑溶液之造粒方法（旋轉造粒法）、使用攪拌翼 等施予原料粉體的流動，再以噴灑霧狀之黏合劑溶液之造 粒方法（攪拌造粒法）等。 在包覆著粒狀組成物之橡膠及石蠟之混合物中，因應 必要可調配與粒狀組成物中之相同或相異之農藥活性成 份，亦可調配不具活性之各種助劑之農藥。此時，可在橡 膠及石蠟之混合物上添加農藥活性成份或助劑、以均勻的 懸浮液包覆上述粒狀組成物之製造方法是為方便。 13 314623D01 201036541 狀二亦可因應必要而調配與粒 、、錄夕^ 農#活性成份，亦可調配不具 ' 助劑之農藥。此時’在包覆製劑上喷灑霧狀 該等成份之遇合懸浮液而乾燥之方法;在該等=: 或黏合劑溶液而_著在包覆製劑 本發明之持續釋放化包覆製劑，從該技術可提供：可U albomculatus), a winter long-distance ($XPanaorus japonicus), love white-kal (Panaorus csikii), tea l Qin KNeolethaeus da]iasi), Ji Changyi (iVysius p]ebeii/s), south slender elephant ( Paromius piratoides), Paromibrachius luridus, Pamerarma rustica, PacAj^ro/itfta anteimaia, Eucosmetus pallicornis, micro-long rod (Lygaeus 10 314623D01 201036541 egues tris), Aga scorpion (Togo Zze/Bipiertys), etc. Lygaeidae; PyrjrAocoris siMrict/s, etc. Pyrrhocoridae; o/Hoeocert/s /nar^'iiij'yeniris), long shouldered scorpion scorpion (C7eti/s, deti/s rt/siicus, fine needle rim (C/eii/s pimctiger), a little The homologous rod (Homoeocerus unipunctatus) and the like (Coreidae); the genus arapiesii/s Li/n'coior, the Chinese phylum (Zepiocorisa cMfleiisis), the scorpion scorpion (Leptocorisa oratorius), cardamom cJaFa (Alydidae); Aeschynteles, A. chrysalis (StictopJeurt/s pw3ciat〇i2er7〇si/s), etc. Rhodalidae; Lurgaster iestiid!-£2aria), etc. (Scute 11 erida6); Gonopsi's af/inis, Ze!ia Aeheri, and rice locust (Car^ia /iu/neriger), Carpocoris purpureipermis, Dolycoris /?accari/ffl, Nasal scorpion (10) sicyia retj, ci/Jaia), Eysarcoris annamita, two K 椿Eysarcoris is a tiger), a large white star (Eysarcoris _/etn·si), a white star aei^eus, a white star (£ySarco_ris ventralis), a tea-winged elephant (Halyoinorphr picus), a rice-rolled elephant (La^yfloto) /nus e/a^ah/s), ffieudia WoJacea, Oezara ai3ieMata), Wezara W Wdda, Pa Jo/Hena osa, a word 11 314623D01 201036541 (The corpse iezMor yang, orange tea wing green 椿 ( (巧巧仏 (4) stali), 江痛$XPygomenida b Angalensis) ^ (Scoti/iopAara iwricia), etc., can inhibit the speckle produced by the aspiration of the Pentatomidae. In addition, the treatment of the drug before the transplanting can also control the rice fever that occurs during the nursery. In the treatment before the transplanting, specific examples thereof include: mixing treatment of seedlings, soiling, and seedling boxes between the seedling stage and the transplanting stage. The amount of the sustained release coating preparation to be treated by each of the specific treatment methods is not particularly limited, but it is preferably about 30 to 150 g in a general rice seedling box (about 30 cm x 60 cm). The sustained release coating preparation of the present invention can be used regardless of the type of the seedling culture soil, the rice variety, and whether the genetic gene of the rice is recombined, and can be combined with the rice treatment for controlling the infectious diseases of rice and the diseases infected from the seedling cultivation soil. Prevention and treatment of seedling treatment, and other methods such as paddy field treatment or biological control, physical control, and the like. Further, in the planting of rice, a combination of weed control or fertilization is generally carried out with a herbicide, and there is no problem in using the present invention in normal rice planting. In the manufacture of the sustained release coating preparation of the present invention, in addition to rubber, wax and agrochemical active ingredients, various additives (for example, carriers, surfactants, binders, flow aids) used in general pesticide preparations may be added. , stabilizers, etc.). The carrier may, for example, be a vegetable powder (for example, soybean powder or wood flour) or a mineral powder (for example, clay such as kaolin, bentonite or acid white clay, talc such as talc powder, pyrophyllite powder, or the like). Water-soluble load of diatomaceous earth, mica powder, etc., ammonium sulfate, sodium hydrogenate, etc. 314623D01 12 201036541 Body, calcium carbonate, activated carbon, and the like. These carriers may be used alone or in combination of two or more. The surfactant may, for example, be a polyoxyethylene polyoxypropylene block polymer, a lignosulfonate, a leucine benzene sulfonate or a naphthyl naphthate, and the binder may be exemplified by α- The starch, polyvinyl alcohol, carboxymethyl cellulose, etc., and the flow aid can be exemplified by white carbon or the like. The sustained release coating preparation of the present invention is produced by coating a heart material containing a pesticidal active ingredient in a general manner with rubber and wax, in particular, a granular composition containing an active ingredient in advance, and the composition is a core system. Suitable for coating with f) a mixture of rubber and wax. A wide variety of forms are available for the shape of the formulation. For example, various forms such as a spherical shape, a cylindrical shape, a granular shape, a rectangular parallelepiped shape, a disk shape, and a rope shape can be exemplified. In terms of construction, any one having a heart material containing an active ingredient of a pesticide coated with rubber and wax may be used. The above granular composition can be produced by a general method. For example, mixing various auxiliaries and active ingredients of pesticides, adding an appropriate amount of water, after mixing and disturbing enthalpy, by means of mesh extrusion (extrusion granulation method); rotating powder while spraying mist The granulation method of the binder solution (rotary granulation method), the flow of the raw material powder by a stirring blade or the like, and the granulation method (stirring granulation method) of spraying the mist-like binder solution. In the mixture of rubber and paraffin coated with the granular composition, it is necessary to adjust the pesticide active ingredient which is the same or different from the granular composition, and it is also possible to prepare a pesticide which is not active. In this case, it is convenient to add a pesticidal active ingredient or an auxiliary agent to a mixture of rubber and paraffin, and to coat the above granular composition with a uniform suspension. 13 314623D01 201036541 Shape 2 can also be blended with granules, shanghai shanghai # active ingredients, and can also be formulated with pesticides without additives. At this time, a method of spraying a misted suspension of the components on the coated preparation to dry the solution; in the case of: = or a binder solution, in the coated preparation, the sustained release coating preparation of the present invention, Available from this technology:
有效控制在-般製射，由農藥活性成分之特性或製劑中 之含量等問題5丨發對稻之藥害的問題，㈣應插^ 之藥劑。 本發明之持續釋放化包覆製劑中，各成份之調配比例 以製劑整體為100重量份，該農藥活性成分為丨至5〇重量 份，以Ϊ至30重量份為佳，橡膠與蠟之混合物為5至 重量份，以5至30重量份為佳，載體為〇至94重量份， 以40至85重量份為佳。 上述式1所示之化合物[I]通常被認作為新菸鹼劑。化 合物[I]之記號中’鹵素係表示氟、氯、溴、碘、尤以氯為 佳。Cl-4烷基係表示甲基、乙基、正丙基、異丙基、正丁基、 異丁基、第二丁基、第三丁基、以曱基及乙基為佳，尤以 曱基更佳。 式1所示化合物[I]以可尼丁（Clothianidin)、°比蟲胺 (Nitenpyram)、賽速安（Thiamethoxiam)、狄諾扶喃 (Dinotefuran)、益達胺（Imidacloprid)、提録 (Thiacloprid)為佳。 314623D01 14 201036541 式2所示化合物[II]之記號中，Ch烷基係表示甲基、 乙基、正丙基、異丙基。 式2所示化合物[II]或其鹽通常被認作為培丹殺蟲 劑。化合物[II]以培丹（Cartap)、硫賜安（Thiocyclam)為 佳，其鹽之酸部份只要有形成化合物[II]與鹽者，並無特 別限定，而以鹽酸、硫酸、草酸等為佳。 (實施例） 接著舉出實施例與實驗例詳細說明本發明，惟本發明 — 並不僅限定於該實施例等。 實施例1 : 將可尼丁 5. 2份、聚羥乙烯·聚羥丙烯嵌段聚合物0. 8 份、α -澱粉3. 5份、黏土 90. 5份混合後，加入15份水攪 合，使用直徑孔0. 9mm之篩造粒。取造粒乾燥、過篩所得 之可尼丁核粒劑60份，使用複合型造粒包覆裝置葛拉溜 (GX20)，將苯乙烯-丁二烯橡膠乳膠與石蠟之固態成份比例 ❹為4: 1之混合物之固態成分9份包覆而得持續釋放性可尼 丁粒劑。 貫驗例1 . 在槽中育苗箱處理對椿象類之效果 實驗方法： 在紙槽中種植稻（日本晴種）2.5葉苗之株根土壤表面 撒布大量上述實施例1所示藥劑後移種。出穗約7天後以 金雀花覆蓋，其中放養赤鬚細綠椿象成蟲10隻。放養6天 後進行生死檢定，更進行收獲期斑點米的調查。 15 314623D01 « 201036541 實驗結果： 如表1所示，可知施用於育苗箱之該製劑呈示對此害 蟲有高的殺蟲活性，且可抑制由吸汁所致之斑點米的發生。 [表1 ] 育苗箱處理對斑點米椿象之藥效 處理量 放養6天後蟲死率 斑點米率 (mg a. i. /株） (%) (%) 可尼丁粒劑 2. 25 95 0. 7 無處理 — 5 9. 4 貫驗例2 ·’ 在圃場中之育苗箱處理對水稻水象鼻蟲之效果 實驗方法： 在一般的育苗箱所種之稻（HIN0HIKARI種）2.5葉苗之 根株土壤表面撒布大量上述實施例1所示製劑後移種。移 種水田後，處理稻約45株以塑膠板圍起，其中以平均每週 Q 2次放養水稻水象鼻蟲成蟲10隻。調查處理8天、15天以 及22天後20株稻被水稻水象鼻蟲成蟲所致之受害葉率。 處理42天後將處理稻掘出、調查後代幼蟲之密度。 實驗結果：. 如表2所示，可知施用於育苗箱之該製劑可抑制該成 蟲之蟲害，亦可抑制後代的密度。 16 314623D01 201036541 [表2] 育苗箱處理對水稻水象鼻蟲之藥效 藥剤 處理量 受害葉率（％) 後代生存 蟲數 (mg a. i. /株） 8天後 15天後 22天後 隻/12株 持續釋放性 可尼丁粒劑 0. 85 4 7 24 6 無處理 — 36 54 74 107 實驗例3 : 在圃場中之育苗箱處理對白背飛蝨之效果 實驗方法： 在一般的育苗箱所種之稻（HIN0HIKARI種）2. 5葉苗之 根株土壤表面撒布大量上述實施例1所示製劑後移種，將 處理24天、31天、38天、45天以及50天後之20株稻株 撣落進行觀查，調查所寄生之白背飛蝨的蟲數。 實驗結果： 如表3所示，可知施用於育苗箱之該製劑可抑制此害 蟲的密度。 [表3] 育苗箱處理對白背飛蝨之藥效 藥劑 處理量 蟲類（隻）/120株 (mg a· i· /株） 24天後 31天後 38天後 45天後 50天後 持續釋放性 可尼丁粒劑 0. 85 3 18 0 4 8 無處理 387 349 269 61 323 17 314623D01 201036541 實施例2 : 取在實施例1中所得可尼丁核粒劑60份，使用複合型 造粒包覆裝置葛拉溜（GX20)，將苯乙烯-丁二烯橡膠乳膠與 石蠟之固態成份比例為4: 1之混合物作為固態成份6份包 覆而得持續釋放化可尼丁粒劑。 實驗例4 : 在槽中育苗箱處理對椿象類之效果 實驗方法： Ο 在紙槽中所種之稻（日本晴種）2. 5葉苗之株根土壤表 面撒布大量上述實施例2所示製劑後移種。出穗約7天後 以金雀花覆蓋全稻株，其中放養赤鬚細綠椿象成蟲10隻。 放養6天後進行生死檢定，更進行收獲期斑點米之調查。 實驗結果： 如表4所示，可知施用於育苗箱之該製劑呈示對此害 蟲有高的殺蟲活性，且可抑制由吸汁所致之斑點米的發生。 [表4 ] 〇 育苗箱處理對斑點米椿象之藥效 處理量 (mg a· i· /株） 放養6天後蟲死率 (%) 斑點米率（％) 可尼丁粒劑 2. 25 100 0. 7 無處理 — 19 15. 5 實驗例5: 在圃場中之育苗箱處理對水稻水象鼻蟲之效果 貫驗方法· 18 314623D01 201036541 在一般的育苗箱所種之稻（HIN0HIKARI種）2.5葉苗之 根株土壤表面撒布大量上述實施例2所示製劑後移種，移 種後之水田以塑膠板圍住45株稻，在其中以平均每週2次 放養水稻水象鼻蟲成蟲10隻，調查處理8天、14天以及 21天後20株稻被水稻水象鼻蟲所致之受害葉率。處理42 天後將處理稻掘出，調查後代幼蟲之密度。 貫驗結果： 〇 ^如表5所示，可知施用於育苗箱之該製劑可抑制該成 蟲之蟲害，亦可抑制後代之密度。 [表5] 〇Effectively control the problem of medicinal damage caused by the characteristics of the active ingredients of the pesticide or the content of the preparation in the general production, and (4) the medicine to be inserted. In the sustained release coating preparation of the present invention, the proportion of each component is 100 parts by weight of the whole preparation, and the agrochemical active ingredient is 丨 to 5 parts by weight, preferably Ϊ to 30 parts by weight, and a mixture of rubber and wax. The amount is preferably 5 to 30 parts by weight, and the carrier is 〇 to 94 parts by weight, preferably 40 to 85 parts by weight, based on 5 parts by weight. The compound [I] represented by the above formula 1 is generally regarded as a neonicotin agent. In the symbol of the compound [I], "halogen" means fluorine, chlorine, bromine, iodine or especially chlorine. Cl-4 alkyl means methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, t-butyl, preferably decyl and ethyl, especially The base is better. The compound [I] represented by Formula 1 is known as Clothianidin, Nitenpyram, Thiamethoxiam, Dinotefuran, Imidacloprid, and Thiacluprid. ) is better. 314623D01 14 201036541 In the symbol of the compound [II] represented by the formula 2, the Ch alkyl group means a methyl group, an ethyl group, a n-propyl group or an isopropyl group. The compound [II] represented by the formula 2 or a salt thereof is generally recognized as a Pedan insecticide. The compound [II] is preferably Carapap or Thiocyclam, and the acid portion of the salt is not particularly limited as long as it forms the compound [II] and the salt, and hydrochloric acid, sulfuric acid, oxalic acid, etc. are used. It is better. (Embodiment) The present invention will be described in detail below with reference to examples and experimental examples, but the present invention is not limited to the examples and the like. 5份混合, After adding 5 parts of cotinidine, 0.2 parts of polyhydroxyethylene polyhydroxypropylene block polymer, 5 parts of α-starch, 5 parts of clay, and 5 parts of clay, add 15 parts of water to stir And granulated with a sieve having a diameter of 0. 9 mm. 60 parts of the nicotine granules obtained by granulating and sieving were used, and the ratio of the solid content of the styrene-butadiene rubber latex to the paraffin was reduced by using a composite granulation coating device GLA20. The solid component of the 4:1 mixture was coated in 9 parts to obtain a sustained release koning granule. Test Example 1. Effect of the nursery box treatment on the mites in the tank Experimental method: Planting the soil surface of the roots of the 2.5-leaf seedlings of rice (Nipponbare) in the paper trough. A large amount of the above-mentioned agent shown in Example 1 was sprinkled and then transplanted. After about 7 days of earing, it was covered with gorse, and 10 of them were stocked with green mites. After 6 days of stocking, the life and death test was carried out, and the spotted rice in the harvest period was investigated. 15 314623D01 « 201036541 Experimental results: As shown in Table 1, it was found that the preparation applied to the nursery box showed high insecticidal activity against the pest and inhibited the occurrence of spotted rice caused by the juice suction. [Table 1] The efficiency of the treatment of the seedling box treatment on the spotted rice bran is 6 days after the stocking rate of the spot rate (mg ai / strain) (%) (%) The nitinol granules 2. 25 95 0. 7 No treatment - 5 9. 4 Test example 2 · The effect of the nursery box treatment on the rice water weevil in the open field: The root soil of the 2.5 seedlings of the rice (HIN0HIKARI species) planted in the general nursery box The surface was sprinkled with a large amount of the preparation shown in the above Example 1 and then transferred. After transplanting the paddy field, about 45 strains of rice were treated with plastic sheets, and 10 of the rice weevil adults were stocked on average Q 2 times a week. The diseased leaf rate of 20 rice-stained rice weevil adults was investigated after 8 days, 15 days, and 22 days. After 42 days of treatment, the rice was excavated and the density of the offspring larvae was investigated. Experimental results: As shown in Table 2, it was found that the preparation applied to the nursery box inhibited the insect pests and inhibited the density of the offspring. 16 314623D01 201036541 [Table 2] The effect of seedling box treatment on rice water weevil 剤 treatment rate 叶 leaf rate (%) number of surviving worms (mg ai / strain) 8 days after 15 days after 22 days only / 12 sustained release koning granules 0. 85 4 7 24 6 No treatment - 36 54 74 107 Experimental example 3: Effect of seedling box treatment on white backed planthopper in open field Experimental method: In general nursery box Planting rice (HIN0HIKARI species) 2. The root surface of the roots of the 5 leaf seedlings was sprinkled with a large amount of the preparation shown in Example 1 and transplanted, and 20 rice plants were treated for 24 days, 31 days, 38 days, 45 days, and 50 days. The plant was observed and investigated, and the number of insects parasitized by the whitebacked planthopper was investigated. Experimental results: As shown in Table 3, it was found that the preparation applied to the nursery box suppressed the density of the pest. [Table 3] The seedling box treatment of the medicinal effect of the whitebacked planthopper (2) / 120 strains (mg a · i · / strain) after 24 days, after 31 days, after 38 days, after 45 days, after 50 days Released nicotinic granules 0. 85 3 18 0 4 8 No treatment 387 349 269 61 323 17 314623D01 201036541 Example 2: 60 parts of the cannidine nuclear granules obtained in Example 1 were used, and composite granulation was used. The coating device GLA20 (GX20) is a mixture of styrene-butadiene rubber latex and paraffin having a solid component ratio of 4:1 as a solid component of 6 parts to obtain a sustained release of the nicotine granule. Experimental Example 4: Effect of the seedling box treatment on the mites in the tank Experimental method: 稻 A large amount of the preparation shown in Example 2 was sprinkled on the surface of the soil of the rice planted in the paper tank (Japan sinensis) After transplanting. About 7 days after the earing, the whole rice plant was covered with gorse, and 10 adults of the red-green pheasant were stocked. After 6 days of stocking, the life and death test was carried out, and the spotted rice in the harvest period was investigated. Experimental results: As shown in Table 4, it was found that the preparation applied to the nursery box showed high insecticidal activity against the pest and inhibited the occurrence of spotted rice caused by the juice suction. [Table 4] The effect of treatment on the spotted rice bran (〇 a · i· / strain) After 6 days of stocking, the mortality rate (%) The spotted rice rate (%) The canon granules 2. 25 100 0. 7 No treatment - 19 15. 5 Experimental example 5: Method for the effect of the nursery box treatment on rice water weevil in the open field · 18 314623D01 201036541 Rice grown in the general nursery box (HIN0HIKARI species) 2.5 The root surface of the leaf seedlings was sprinkled with a large amount of the above-mentioned preparations shown in Example 2, and the seedlings were transplanted, and the paddy fields were surrounded by 45 rice trees with plastic plates, and the rice water weevil adults were stocked twice a week on average. Only, the diseased leaf rate of 20 rice quilts caused by rice water weevil was investigated after 8 days, 14 days, and 21 days. After 42 days of treatment, the rice was excavated and the density of the offspring larvae was investigated. Results of the test: 〇 ^ As shown in Table 5, it was found that the preparation applied to the nursery box inhibited the insect pests and inhibited the density of the offspring. [Table 5] 〇
藥劑 處理量 (吨 a. i· /株）. 受害葉率（％) 後代生存 蟲數 隻/12株 持續釋放性 1尼丁粒劑 無處理 8天後一 14夭德 21天後 2. 25Chemical treatment volume (ton a. i· / strain). Damaged leaf rate (%) Progeny survival Number of insects only /12 strains Sustained release 1 Nitin granules No treatment 8 days later 1 14 夭 21 days later 2. 25
39 實施例 、生、取在實施例1中所得可尼丁核粒劑 60份，使用複合型 ^粒包覆裝置葛拉溜（GX_2〇)，將苯乙烯_ 丁二烯橡膠乳 ^石蠟以及二氧化矽微粉末之固態成份比例為80 : 20 : 、，之此δ物作為固態成份9份包覆而得持續釋放北可尼丁 板劑。 實驗例6 : 19 314623D01 201036541 在槽中育苗箱處理對椿象類之效果 實驗方法： 在紙槽中所種之稻（日本晴種）2. 5葉苗之株根土壤表 面撒布大量上述實施例3所示製劑後移種。出穗約7天後 以金雀花覆蓋全稻株，其中放養赤鬚細綠椿象成蟲10隻。 放養6天後進行生死檢定，更進行收獲期斑點米之調查。 實驗結果： 如表6所示，可知施用於育苗箱之該製劑呈示對此害 〇 蟲有高的殺蟲活性，且可抑制由吸汁所致之斑點米的發生。 [表6] 育苗箱處理對斑點米椿象之藥效 處理量 (mg a. i· /株） 放養6天後蟲死率 斑點米率（％) (%) 可尼丁粒劑 2. 25 86 2. 9 無處理 — 19 15. 5 Q 實驗例7 : 在圃場中之育苗箱處理對水稻水象鼻蟲之效果 實驗方法： 在一般的育苗箱所種之稻（HIN0HIKARI種）2.5葉苗之 根株土壤表面撒布大量上述實施例3所示製劑後移種，移 種後之水田以塑膠板圍住45株處理稻，在其中以平均每週 2次放養水稻水象鼻蟲成蟲10隻，調查處理8天、14天以 及21天後20株稻被水稻水象鼻蟲所致之受害葉率。處理 42天後將處理稻掘出，調查後代幼蟲之密度。 20 314623D01 201036541 。 實驗結果： 如表7所示，可知施用於育苗箱之該製劑可抑制該成 蟲之蟲害，亦可抑制後代之密度。 [表7] 育苗箱處理對水稻水象鼻蟲之藥效 藥劑 處理量 受害葉率（％) 後代生存蟲數 (mg a. i. /株） 8天後 14天後 21天後 隻/12株 持續釋放性 可尼丁粒劑 2. 25 3 1 1 0 無處理 — 14 46 39 86 [發明之效果] 如上述，本發明係可提供：可控制對水稻病蟲害具防 治效果之農藥活性成分之溶出性，可防治連既有的市售製 劑都棘手之出穗期以後之蟲害者，在插秧前的1次藥劑處 理便可防治在水稻栽種期間之主要病蟲害之藥劑。 〇 【圖式簡單說明】 第1圖係呈示本發明製劑之基本構造之圖解。 【主要元件符號說明】 無 〇 21 314623D0139 Examples, raw, taking 60 parts of the nicotine granules obtained in Example 1, using a composite type of particle coating device GLA (GX 2 〇), styrene-butadiene rubber emulsifiable wax and The solid content ratio of the cerium oxide micropowder is 80:20: , and the δ substance is coated as 9 parts of the solid component to obtain a sustained release of the kononic sheet. Experimental Example 6: 19 314623D01 201036541 The effect of the seedling box treatment on the mites in the tank Experimental method: The rice roots (Japan sylvestris) planted in the paper trough 2. The root surface of the roots of the 5 leaf seedlings was sprinkled a large amount of the above Example 3 The preparation was transferred after the preparation. About 7 days after the earing, the whole rice plant was covered with gorse, and 10 adults of the red-green pheasant were stocked. After 6 days of stocking, the life and death test was carried out, and the spotted rice in the harvest period was investigated. Experimental results: As shown in Table 6, it was found that the preparation applied to the nursery box showed high insecticidal activity against the mites and inhibited the occurrence of spotted rice caused by the juice suction. [Table 6] The effect of the treatment of the nursery box on the spotted rice bran (mg a. i· / strain) The spot rate of the insecticide after 6 days of stocking (%) (%) Knifein granules 2. 25 86 2. 9 No treatment - 19 15. 5 Q Experimental example 7: Effect of seedling box treatment on rice water weevil in the open field: Rice planted in the general nursery box (HIN0HIKARI species) 2.5 leaf seedlings The surface of the root soil was sprinkled with a large amount of the preparation shown in Example 3, and the seedlings were transplanted. The paddy field was transplanted with 45 plastic rice plants in a paddy field, and 10 rice weedworm adults were stocked on average twice a week. The rate of damaged leaves caused by 20 rice water weevils after 8 days, 14 days and 21 days. After 42 days of treatment, the rice was excavated and the density of the offspring larvae was investigated. 20 314623D01 201036541 . Experimental results: As shown in Table 7, it was found that the preparation applied to the nursery box inhibited the insect pests and inhibited the density of the offspring. [Table 7] The effect of the nursery box treatment on the rice water weevil The treatment rate of the affected leaf rate (%) The number of surviving insects (mg ai / strain) After 8 days, 14 days after 21 days, only /12 sustained release Sexual nitrile granules 2. 25 3 1 1 0 No treatment - 14 46 39 86 [Effect of the invention] As described above, the present invention provides a dissolution property of an active ingredient of a pesticide which can control the control effect on rice pests and diseases, It can prevent and control the pests after the earing stage of the existing commercial preparations, and the first time before the transplanting, the main pests and diseases during the rice planting can be controlled. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a diagram showing the basic configuration of a preparation of the present invention. [Main component symbol description] None 〇 21 314623D01