TW200940048A - Novel use of amidine derivatives - Google Patents

Novel use of amidine derivatives Download PDF

Info

Publication number: TW200940048A
Authority: TW; Taiwan
Prior art keywords: spp; genus; nematode; livestock; patent application
Prior art date: 2007-12-19

Application number

TW097149310A

Other languages

English (en)

Chinese (zh)

Inventor

Achim Harder

Dittmar Nerger

Original Assignee

Bayer Animal Health Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-19

Filing date

2008-12-18

Publication date

2009-10-01

2008-12-18 Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh

2009-10-01 Publication of TW200940048A publication Critical patent/TW200940048A/zh

Links

150000001409 amidines Chemical class 0.000 title abstract 2
244000079386 endoparasite Species 0.000 claims abstract description 17
244000144972 livestock Species 0.000 claims abstract description 16
XOIOGKHKNQYULW-HTNNXBMUSA-N tribendimidine Chemical compound C1=CC(/N=C(\C)N(C)C)=CC=C1\N=C\C(C=C1)=CC=C1\C=N\C1=CC=C(\N=C(/C)N(C)C)C=C1 XOIOGKHKNQYULW-HTNNXBMUSA-N 0.000 claims abstract description 16
241000244206 Nematoda Species 0.000 claims description 84
-1 amine phenyl hydrazine derivative Chemical class 0.000 claims description 37
150000003839 salts Chemical class 0.000 claims description 18
238000002360 preparation method Methods 0.000 claims description 15
208000015181 infectious disease Diseases 0.000 claims description 13
239000003814 drug Substances 0.000 claims description 11
241001124076 Aphididae Species 0.000 claims description 10
241000244203 Caenorhabditis elegans Species 0.000 claims description 10
241000238631 Hexapoda Species 0.000 claims description 9
241000869417 Trematodes Species 0.000 claims description 9
238000000034 method Methods 0.000 claims description 9
241000238876 Acari Species 0.000 claims description 8
OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
241001600407 Aphis <genus> Species 0.000 claims description 5
244000000013 helminth Species 0.000 claims description 5
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150000001875 compounds Chemical class 0.000 claims description 3
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
239000012528 membrane Substances 0.000 claims description 3
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125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 2
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229910052757 nitrogen Inorganic materials 0.000 claims 2
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125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
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ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
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239000000049 pigment Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920006375 polyphtalamide Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
229940043349 potassium metabisulfite Drugs 0.000 description 1
235000010263 potassium metabisulphite Nutrition 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002028 premature Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
DPBVJRXPSXTHOL-UHFFFAOYSA-N propyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCC DPBVJRXPSXTHOL-UHFFFAOYSA-N 0.000 description 1
229960005134 pyrantel Drugs 0.000 description 1
YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
238000011160 research Methods 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
229930002330 retinoic acid Natural products 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
229910052707 ruthenium Inorganic materials 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000012748 slip agent Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000010408 sweeping Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000001648 tannin Substances 0.000 description 1
235000018553 tannin Nutrition 0.000 description 1
229920001864 tannin Polymers 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

TW097149310A 2007-12-19 2008-12-18 Novel use of amidine derivatives TW200940048A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102007061262A DE102007061262A1 (de)	2007-12-19	2007-12-19	Neue Verwendung von Tribendimidin

Publications (1)

Publication Number	Publication Date
TW200940048A true TW200940048A (en)	2009-10-01

Family

ID=40350125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW097149310A TW200940048A (en)	2007-12-19	2008-12-18	Novel use of amidine derivatives

Country Status (7)

Country	Link
AR (1)	AR070037A1 (es)
CL (1)	CL2008003652A1 (es)
DE (1)	DE102007061262A1 (es)
PE (1)	PE20091266A1 (es)
TW (1)	TW200940048A (es)
UY (1)	UY31519A1 (es)
WO (1)	WO2009077162A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102008030764A1 (de)	2008-06-28	2009-12-31	Bayer Animal Health Gmbh	Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden
CN105998975A (zh) *	2016-06-30	2016-10-12	容县祥益农牧有限公司	一种兽用驱除吸虫的中药组合物、制备方法及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2029298C3 (de)	1970-06-13	1980-04-17	Bayer Ag, 5090 Leverkusen	Aminophenylamidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2029299C3 (de) *	1970-06-13	1980-08-21	Bayer Ag, 5090 Leverkusen	Neue Aminophenylamidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

2007
- 2007-12-19 DE DE102007061262A patent/DE102007061262A1/de not_active Withdrawn
2008
- 2008-12-09 CL CL2008003652A patent/CL2008003652A1/es unknown
- 2008-12-09 UY UY31519A patent/UY31519A1/es not_active Application Discontinuation
- 2008-12-09 AR ARP080105332A patent/AR070037A1/es unknown
- 2008-12-09 PE PE2008002032A patent/PE20091266A1/es not_active Application Discontinuation
- 2008-12-16 WO PCT/EP2008/010692 patent/WO2009077162A1/de not_active Ceased
- 2008-12-18 TW TW097149310A patent/TW200940048A/zh unknown

Also Published As

Publication number	Publication date
AR070037A1 (es)	2010-03-10
DE102007061262A1 (de)	2009-06-25
CL2008003652A1 (es)	2009-12-18
WO2009077162A1 (de)	2009-06-25
UY31519A1 (es)	2009-08-03
PE20091266A1 (es)	2009-08-22

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