TW200911811A - Imidazopyrazines as protein kinase inhibitors - Google Patents

Imidazopyrazines as protein kinase inhibitors Download PDF

Info

Publication number: TW200911811A
Authority: TW; Taiwan
Prior art keywords: group; alkyl; compound; heteroaryl; aryl
Prior art date: 2007-06-14

Application number

TW097121942A

Other languages

English (en)

Chinese (zh)

Inventor

Tao Yu

David B Belanger

Angela D Kerekes

zhao-yang Meng

Jayaram R Tagat

Sara J Esposite

Amit K Mandal

Yushi Xiao

Bheemashankar A Kulkarni

Yonglian Zhang

Patrick J Curran

Ronald J Doll

Arshad M Siddiqui

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-14

Filing date

2008-06-12

Publication date

2009-03-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40002934&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200911811(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-06-12 Application filed by Schering Corp filed Critical Schering Corp

2009-03-16 Publication of TW200911811A publication Critical patent/TW200911811A/zh

Links

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OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
238000007631 vascular surgery Methods 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
230000001755 vocal effect Effects 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
210000004885 white matter Anatomy 0.000 description 1
235000014101 wine Nutrition 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
239000011701 zinc Substances 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW097121942A 2007-06-14 2008-06-12 Imidazopyrazines as protein kinase inhibitors TW200911811A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94399907P	2007-06-14	2007-06-14
US98793207P	2007-11-14	2007-11-14

Publications (1)

Publication Number	Publication Date
TW200911811A true TW200911811A (en)	2009-03-16

Family

ID=40002934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW097121942A TW200911811A (en)	2007-06-14	2008-06-12	Imidazopyrazines as protein kinase inhibitors

Country Status (10)

Country	Link
EP (1)	EP2170892A2 (fr)
JP (1)	JP2010529195A (fr)
CN (1)	CN101772500A (fr)
AR (1)	AR066958A1 (fr)
CA (1)	CA2690557A1 (fr)
CL (1)	CL2008001745A1 (fr)
MX (1)	MX2009013729A (fr)
PE (1)	PE20090365A1 (fr)
TW (1)	TW200911811A (fr)
WO (1)	WO2008156614A2 (fr)

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EP3105219B9 (fr)	2014-02-13	2018-10-03	Incyte Corporation	Cyclopropylamines en tant qu'inhibiteurs de lsd1
US9527835B2 (en)	2014-02-13	2016-12-27	Incyte Corporation	Cyclopropylamines as LSD1 inhibitors
PT3105218T (pt)	2014-02-13	2019-12-05	Incyte Corp	Ciclopropilaminas como inibidores de lsd1
DK3105226T3 (da)	2014-02-13	2019-10-14	Incyte Corp	Cyclopropylaminer som lsd1-inhibitorer
TWI687419B (zh)	2014-07-10	2020-03-11	美商英塞特公司	作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
TW201613925A (en)	2014-07-10	2016-04-16	Incyte Corp	Imidazopyrazines as LSD1 inhibitors
US9758523B2 (en)	2014-07-10	2017-09-12	Incyte Corporation	Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007722A1 (fr)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
EP3626720A1 (fr)	2015-04-03	2020-03-25	Incyte Corporation	Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1
KR102710120B1 (ko)	2015-08-12	2024-09-27	인사이트 홀딩스 코포레이션	Lsd1 저해제의 염
PE20190377A1 (es)	2016-04-22	2019-03-08	Incyte Corp	Formulaciones de un inhibidor de lsd 1
WO2018102552A1 (fr)	2016-11-30	2018-06-07	Case Western Reserve University	Combinaisons d'inhibiteurs de 15-pgdh avec des corcostéroïdes et/ou des inhibiteurs du tnf et leurs utilisations
JP2020514323A (ja)	2017-02-06	2020-05-21	ケースウエスタンリザーブユニバーシティ	短鎖デヒドロゲナーゼ活性を調節する組成物と方法
US11419875B2 (en) *	2017-03-31	2022-08-23	Aurigene Discovery Technologies Limited	Compounds and compositions for treating hematological disorders
CN107954977A (zh) *	2017-12-15	2018-04-24	上海鼎雅药物化学科技有限公司	雷替曲塞中间体的合成方法
US10968200B2 (en)	2018-08-31	2021-04-06	Incyte Corporation	Salts of an LSD1 inhibitor and processes for preparing the same
EA202191422A1 (ru)	2018-11-21	2021-10-21	Кейс Вестерн Ризерв Юниверсити	Композиции и способы модулирования активности короткоцепочечной дегидрогеназы
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2008
- 2008-06-11 PE PE2008001001A patent/PE20090365A1/es not_active Application Discontinuation
- 2008-06-11 EP EP08768351A patent/EP2170892A2/fr not_active Withdrawn
- 2008-06-11 WO PCT/US2008/007295 patent/WO2008156614A2/fr not_active Ceased
- 2008-06-11 CN CN200880101960A patent/CN101772500A/zh active Pending
- 2008-06-11 AR ARP080102481A patent/AR066958A1/es not_active Application Discontinuation
- 2008-06-11 JP JP2010512177A patent/JP2010529195A/ja not_active Withdrawn
- 2008-06-11 MX MX2009013729A patent/MX2009013729A/es not_active Application Discontinuation
- 2008-06-11 CA CA2690557A patent/CA2690557A1/fr not_active Abandoned
- 2008-06-12 TW TW097121942A patent/TW200911811A/zh unknown
- 2008-06-12 CL CL2008001745A patent/CL2008001745A1/es unknown

Also Published As

Publication number	Publication date
JP2010529195A (ja)	2010-08-26
MX2009013729A (es)	2010-01-25
CL2008001745A1 (es)	2008-12-05
CN101772500A (zh)	2010-07-07
CA2690557A1 (fr)	2008-12-24
WO2008156614A3 (fr)	2009-02-12
WO2008156614A2 (fr)	2008-12-24
PE20090365A1 (es)	2009-04-04
AR066958A1 (es)	2009-09-23
EP2170892A2 (fr)	2010-04-07

Publication	Publication Date	Title
TW200911811A (en)	2009-03-16	Imidazopyrazines as protein kinase inhibitors
JP7216705B2 (ja)	2023-02-02	Ｔｙｋ２阻害剤およびその使用方法
TWI421078B (zh)	2014-01-01	關卡激酶抑制劑及其用途
JP5052518B2 (ja)	2012-10-17	プロテインキナーゼインヒビターとしてのピラゾロピリミジン
US20070105864A1 (en)	2007-05-10	Methods for inhibiting protein kinases
BRPI0618520A2 (pt)	2011-09-06	imidazopirazinas como inibidores de proteìna cinase
TWI333953B (en)	2010-12-01	Pyrazolopyrimidines as protein kinase inhibitors
TW200808802A (en)	2008-02-16	Imidazopyrazines as protein kinase inhibitors
TW200829588A (en)	2008-07-16	Imidazopyrazines as protein kinase inhibitors
JP2021508703A (ja)	2021-03-11	Ｉｒａｋ分解剤およびそれらの使用
EP2935260A1 (fr)	2015-10-28	Dihydropyridopyrazinones inhibitrices de protéine bet
TW200804387A (en)	2008-01-16	Novel imidazopyrazines as cyclin dependent kinase inhibitors
CN101316847A (zh)	2008-12-03	用作蛋白激酶抑制剂的吡唑并(1,5a)嘧啶化合物
CA2710929A1 (fr)	2009-08-06	Imidazopyrazines comme inhibiteurs de proteines kinases
AU2006302435B2 (en)	2012-11-22	Use of pyrazolo [1 , 5 -a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases
TW202517253A (zh)	2025-05-01	Cdk2抑制劑及其用途
MX2008004668A (en)	2008-09-02	Use of pyrazolo [1 , 5 -a]pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases
TW201231467A (en)	2012-08-01	Pyrazolopyridine kinase inhibitors