TW200845914A - Manufacture method of polysaccharide spherule and compostion with the same - Google Patents
Manufacture method of polysaccharide spherule and compostion with the same Download PDFInfo
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- TW200845914A TW200845914A TW096117950A TW96117950A TW200845914A TW 200845914 A TW200845914 A TW 200845914A TW 096117950 A TW096117950 A TW 096117950A TW 96117950 A TW96117950 A TW 96117950A TW 200845914 A TW200845914 A TW 200845914A
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- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 38
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims abstract description 8
- 150000004676 glycans Chemical class 0.000 title claims abstract 13
- 239000000243 solution Substances 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 239000000084 colloidal system Substances 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 11
- 239000011259 mixed solution Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000002245 particle Substances 0.000 claims description 32
- 239000008187 granular material Substances 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 6
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 6
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims description 5
- 229940035936 ubiquinone Drugs 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 230000003078 antioxidant effect Effects 0.000 claims description 3
- 235000006708 antioxidants Nutrition 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 2
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims 2
- 239000000052 vinegar Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 1
- 235000013824 polyphenols Nutrition 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 235000021419 vinegar Nutrition 0.000 claims 1
- 150000004804 polysaccharides Chemical class 0.000 description 25
- 239000013543 active substance Substances 0.000 description 8
- 210000000813 small intestine Anatomy 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
200845914 九、發明說明： ^ 【發明所屬之技術領域】 ' 本發明是有關一種多醣膠體顆粒之製造方法及其組成 物，特別是一種可延緩釋放及保護被包覆物之多醣膠體顆粒 之製造方法及其組成物。 【先前技術】 Φ 由於生物科技的進步，許多具有生理活性或美容功能之 物質被發現及萃取出來。除了作為藥物及化粧品的用途外， 為了迎合消費者養生及愛美的風潮，這類物質亦被添加於食 品中作為一健康食品或美容食品。200845914 IX. Description of the invention: ^ [Technical field of invention] The present invention relates to a method for producing a polysaccharide colloidal particle and a composition thereof, and particularly to a method for producing a polysaccharide colloidal particle capable of delaying release and protecting a coated object And its composition. [Prior Art] Φ Due to advances in biotechnology, many substances with physiologically active or cosmetic functions have been discovered and extracted. In addition to its use as a medicine and cosmetics, in order to cater to the trend of consumer health and beauty, these substances have also been added to food as a health food or beauty food.
由於食品系統為微生物易於生長的環境，因此為了延長 食品的保存期限，食品之製程中必須包含一高溫殺菌製程。 依殺菌條件的不同，殺菌溫度約為100至130°c，如此的高 溫易使這類活性物質失去活性。此外，人體所攝取的食物， 其營養成份多由小腸所吸收，這類活性物質亦不例外。因此， • 這類活性物質在到達小腸前，必須先經過胃，而胃酸之低pH 環境(pH值約為1至2)同樣容易使這類活性物質失去活性。 綜上所述，如何避免這類活性物質受到高温及低pH的 破壞，使其能到達小腸供人體吸收便是目前極需努力的目標。 【發明内容】 針對上述問題，本發明目的之一是提供一種多醣膠體顆 粒之製造方法及其組成物，其將前述之活性物質包覆於顆粒 5 200845914 中，以避免其受到高溫及低pH的破壞，而能夠到達小腸供 ^ 人體吸收。 V 為了達到上述目的，本發明一實施例之多醣膠體顆粒之 製造方法，其步驟包含：分散一多醣膠體於一水溶液中，以 形成一多醣膠體溶液；溶解一被包覆物於該多醣膠體溶液 中，以形成一混合溶液；以及將該混合溶液滴入一固化溶液， 待固化後即形成該顆粒。 為了達到上述目的，本發明另一實施例之包含多醣膠體 φ 顆粒之組合物，其是供攝食之用，該組合物包含一載劑、一 顆粒以及一被包覆物。顆粒具有一外膜，其是由一多醣膠體 經一固化溶液固化後所形成。被包覆物則包埋於顆粒中。 以下藉由具體實施例配合所附的圖式詳加說明，當更容 易瞭解本發明之目的、技術内容、特點及其所達成之功效。 【實施方式】 請參照圖1，說明本發明之一較佳實施例之多醣膠體顆粒之 # 製造方法。首先，將一多醣膠體分散於一水溶液中，以形成 一多醣膠體溶液（S11)。接著，將一被包覆物溶解於該多醣膠 體溶液中，以形成一包含被包覆物與多醣膠體之混合溶液 (S12)。最後，將混合溶液滴入一固化溶液中，待固化後即形 成本發明較佳實施例之顆粒（S13)。較佳者，在滴入混合溶液 - 時，需不斷攪拌固化溶液，以避免形成之顆粒凝集在一起。 - 本發明較佳實施例之製造方法更可包含靜置多醣膠體溶 液之步驟，使多醣膠體能與水溶液充份水合。亦可在形成顆 粒後，將該顆粒進行殺菌製程，之後再進行水洗以洗去附著 之固化溶液。 6 200845914 月’J述之多醣膠體可為一褐藻酸或其衍生物，例如褐藻酸 納。於一實施例中，多醣膠體溶液之濃度為1至3%重量比。 被包覆物較佳為具有生理活性或美容功能之物質，例如多酉分 類、生物黃|同類、抗氧化類、維生素類、蛋白質類或油脂類 之物貝。於一實施例中，被包覆物為泛醌(ubiquinone)，亦即 一般所稱之輔酶Ql〇(Coenzyme Q10)。固化溶液可為氯化鈣 溶液，於一實施例中，固化溶液之濃度為0·1至4%重量比。Since the food system is an environment in which microorganisms are easy to grow, in order to prolong the shelf life of the food, the food processing must include a high temperature sterilization process. The sterilization temperature is about 100 to 130 ° C depending on the sterilization conditions, and such high temperatures tend to deactivate such active substances. In addition, the foods ingested by the human body are mostly absorbed by the small intestine, and such active substances are no exception. Therefore, • such active substances must pass through the stomach before reaching the small intestine, and the low pH environment of gastric acid (pH 1 to 2) is also prone to inactivation of such active substances. In summary, how to avoid the destruction of such active substances by high temperature and low pH, so that it can reach the small intestine for absorption by the human body is currently the goal of hard work. SUMMARY OF THE INVENTION In view of the above problems, one of the objects of the present invention is to provide a method for producing a polysaccharide colloidal particle and a composition thereof, which are coated with the above-mentioned active material in the particle 5 200845914 to avoid high temperature and low pH. Destruction, and can reach the small intestine for the body to absorb. In order to achieve the above object, a method for producing a polysaccharide colloidal particle according to an embodiment of the present invention comprises the steps of: dispersing a polysaccharide colloid in an aqueous solution to form a polysaccharide colloid solution; and dissolving a coated material on the polysaccharide. In the colloidal solution, a mixed solution is formed; and the mixed solution is dropped into a solidified solution, which is formed after being solidified. In order to achieve the above object, a composition comprising polysaccharide colloid φ particles according to another embodiment of the present invention is for feeding, and the composition comprises a carrier, a granule and a coating. The granules have an outer film which is formed by solidification of a polysaccharide colloid through a solidification solution. The coated object is embedded in the granules. The purpose, technical contents, features and effects achieved by the present invention will be more readily understood from the following detailed description of the embodiments. [Embodiment] Referring to Figure 1, a method of producing a polysaccharide colloidal particle according to a preferred embodiment of the present invention will be described. First, a polysaccharide colloid is dispersed in an aqueous solution to form a polysaccharide colloidal solution (S11). Next, a coated object is dissolved in the polysaccharide colloidal solution to form a mixed solution containing the coated material and the polysaccharide colloid (S12). Finally, the mixed solution is dropped into a solidified solution, and after curing, the particles of the preferred embodiment of the invention are formed (S13). Preferably, when the mixed solution is dropped, the solidified solution is continuously stirred to prevent the formed particles from agglutinating together. - The manufacturing method of the preferred embodiment of the present invention may further comprise the step of standing the colloidal solution of the polysaccharide to enable the polysaccharide colloid to be fully hydrated with the aqueous solution. Alternatively, after the particles are formed, the particles are subjected to a sterilization process, and then washed with water to wash away the adhered solid solution. 6 200845914 The polysaccharide colloid described in the 'J can be a brown alginic acid or a derivative thereof, such as sodium alginate. In one embodiment, the concentration of the polysaccharide colloidal solution is from 1 to 3% by weight. The coated material is preferably a substance having physiological activity or a cosmetic function, such as a polysaccharide, a biological yellow, a similar, an antioxidant, a vitamin, a protein or a fat. In one embodiment, the coated material is ubiquinone, also known as Coenzyme Q10. The curing solution may be a calcium chloride solution. In one embodiment, the concentration of the curing solution is from 0.1 to 4% by weight.
，發明之一較佳實施例之包含多醣膠體顆粒之組合物，其 ===者攝食之用。本發明較佳實施例之組合物包含- 可i受之載tTf—被包覆物。於〜實施例中，載劑為食品 J接又之载劑，例如水醇溶液、懸 顆粒即是由上述製造方法所製成之等。 經固化溶液固化後所形成之外膜。被^目、=夕酶膠體 中。顆粒及被包覆物質之成份如前=„被包埋於顆粒 注意者，本發明較佳實施例之組合物主^ t此不再費述。需 此’本翻㈣技術領財具有 ^作為攝食之用，因 施例之組合物中添加安定劑、調味•，丨者可於本發明較佳實 來增加消♦費者之喜好性。此外，本^日、呈色劑或以上之奴合 可先將顆粒與載劑分別殺菌後再加：：之組合物之殺菌處理 混合後再加以殺菌。 & 5，或疋顆粒與载劑 請參照圖2，其為模擬本發明之顇 物之溶出情形，其中多醣膠體為褐"^化道時，被包覆 醌，固化溶液為氯化鈣溶液。模擬方、次、曰，被包覆物質為泛 過殺菌處理之顆粒置於人工胃液令式疋先將製備完成並經 置於人工腸液_ 5小時後，觀察泛、時，之後取出顆粒再 以看出，顆粒置於人工胃液】小時:之溶出情形。由圖2可 人工腸液中3小時後才開始有少、I無泛驅溶出，而置於 ’醌溶出，5小時後溶出 7 200845914 約49.67%之泛醌，顯示本發明之顆粒可有效保護泛醌並延緩 泛醌於腸道釋放的效果。 綜合上述，本發明之多醣膠體顆粒之製造方法及其組成 物，其將具有生理活性或美容功能之物質以一多醣膠體包覆 成一顆粒，使此類活性物質於熱處理過程中有相對較低的熱 破壞。此外，本發明之顆粒於胃液環境中不易溶解，而可於 小腸環境中溶解開來，因此，可相對降低胃液之低pH值環 境對此類活性物質的破壞，而讓食用者吸收到相對較多的此 類活性物質。 以上所述之實施例僅是為說明本發明之技術思想及特 點，其目的在使熟習此項技藝之人士能夠瞭解本發明之内容 並據以實施，當不能以之限定本發明之專利範圍，即大凡依 本發明所揭示之精神所作之均等變化或修飾，仍應涵蓋在本 發明之專利範圍内。 【圖式簡單說明】 圖1為流程圖，顯示本發明一較佳實施例之多醣膠體顆粒之製造 方法。 圖2為模擬本發明一較佳實施例之多醣膠體顆粒於消化道中， 被包覆物溶出情形之實驗結果。 【主要元件符號說明】 S11〜S13 本發明一較佳實施例之製程步驟A composition comprising a polysaccharide colloidal particle according to a preferred embodiment of the invention, wherein === for food intake. The composition of the preferred embodiment of the invention comprises - a tTf-coated article. In the embodiment, the carrier is a carrier of the food J, such as a hydroalcoholic solution, and the suspended particles are prepared by the above-mentioned manufacturing method. The outer film is formed after the solidified solution is solidified. It is in the colloidal body. The composition of the granules and the coated material is as described above. The composition of the preferred embodiment of the present invention is not described here. For the purpose of ingestion, because the stabilizer and seasoning are added to the composition of the embodiment, the person skilled in the present invention can increase the preference of the consumer in the present invention. In addition, the slave of the present day, the coloring agent or the above The granules and the carrier may be separately sterilized and then added: the sterilizing treatment of the composition is mixed and then sterilized. & 5, or 疋 particles and carrier, please refer to Figure 2, which is a simulation of the cockroach of the present invention In the case of dissolution, in which the polysaccharide colloid is brown "^, the crucible is coated, and the solidified solution is a calcium chloride solution. The simulated side, the second, the sputum, the coated material is a sterilized particle placed in the artificial The gastric juice formula is prepared first and placed in the artificial intestinal juice for _ 5 hours, the pan and time are observed, and then the particles are taken out to see that the particles are placed in the artificial gastric juice for an hour: the dissolution condition. The artificial intestinal fluid can be obtained from Fig. 2 After 3 hours, it started to be less, I did not have a flooding solution, and placed '醌 Dissolve, 7 hours after dissolution 7 200845914 about 49.67% of ubiquinone, showing that the particles of the present invention can effectively protect ubiquinone and delay the release of ubiquinone in the intestinal tract. In summary, the method for producing the polysaccharide colloid granule of the present invention And a composition thereof, which has a physiologically active or cosmetically functional substance coated with a polysaccharide colloid into a granule, so that the active substance has relatively low thermal damage during heat treatment. Further, the granule of the present invention is in gastric juice It is not easily dissolved in the environment, but can be dissolved in the small intestine environment. Therefore, the destruction of such active substances can be relatively reduced in the low pH environment of the gastric juice, and the consumer can absorb relatively more such active substances. The embodiments are merely illustrative of the technical spirit and the features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the contents of the present invention and to implement the invention. Equivalent changes or modifications made by the spirit of the present invention should still be included in the scope of the patent of the present invention. 1 is a flow chart showing a method for producing a polysaccharide colloidal particle according to a preferred embodiment of the present invention. Fig. 2 is a view showing an experimental result of simulating dissolution of a polysaccharide colloidal particle in a digestive tract according to a preferred embodiment of the present invention. [Explanation of main component symbols] S11 to S13 Process steps of a preferred embodiment of the present invention
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| TW096117950A TW200845914A (en) | 2007-05-21 | 2007-05-21 | Manufacture method of polysaccharide spherule and compostion with the same |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116333709A (en) * | 2023-03-17 | 2023-06-27 | 陕西科技大学 | A kind of cage microsphere oil displacement particle and preparation method thereof |
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2007
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116333709A (en) * | 2023-03-17 | 2023-06-27 | 陕西科技大学 | A kind of cage microsphere oil displacement particle and preparation method thereof |
| CN116333709B (en) * | 2023-03-17 | 2024-03-22 | 陕西科技大学 | Cage-shaped microsphere oil displacement particle and preparation method thereof |
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