TW200833355A - Peptides that target to tumor blood vessels of lung cancer and applications thereof - Google Patents
Peptides that target to tumor blood vessels of lung cancer and applications thereofInfo
- Publication number
- TW200833355A TW200833355A TW96119331A TW96119331A TW200833355A TW 200833355 A TW200833355 A TW 200833355A TW 96119331 A TW96119331 A TW 96119331A TW 96119331 A TW96119331 A TW 96119331A TW 200833355 A TW200833355 A TW 200833355A
- Authority
- TW
- Taiwan
- Prior art keywords
- peptides
- blood vessels
- target
- lung cancer
- applications
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 210000004204 blood vessel Anatomy 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 title abstract 2
- 201000005202 lung cancer Diseases 0.000 title abstract 2
- 208000020816 lung neoplasm Diseases 0.000 title abstract 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 238000011579 SCID mouse model Methods 0.000 abstract 2
- 238000001574 biopsy Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000002823 phage display Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90098007P | 2007-02-13 | 2007-02-13 | |
| US11/783,926 US8088887B2 (en) | 2007-02-13 | 2007-04-13 | Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200833355A true TW200833355A (en) | 2008-08-16 |
| TWI365748B TWI365748B (en) | 2012-06-11 |
Family
ID=44819110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096119331A TWI365748B (en) | 2007-02-13 | 2007-05-30 | Peptides that target to tumor blood vessels of lung cancer and applications thereof |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TWI365748B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018103064A1 (en) * | 2016-12-09 | 2018-06-14 | Agricultural Technology Research Institute | Cancer stem cell targeting peptide and use thereof |
-
2007
- 2007-05-30 TW TW096119331A patent/TWI365748B/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018103064A1 (en) * | 2016-12-09 | 2018-06-14 | Agricultural Technology Research Institute | Cancer stem cell targeting peptide and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI365748B (en) | 2012-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |